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Figure Chemotherapy Sequencing Chart 6-Manchini_Cover 6/23/143:25PMPage20 2 0 l *Foll F i J First Chemotherapy Agent g o Y u o Vi Trastuzumab Topotecan Temsiro Streptozocin Rituximab Doxor D Pentostatin Pemetrexed Panitumumab Pac D Da Pac Oxa Mitoxantrone Mitomycin Methotrexate Mesna Cyclo D Dacarbazine Cytarabine C Mel Mechlorethamine Leucovorin C Ixabep Irinotecan Ifosfamide C Carboplatin Bl Bevacizumab Idar Gemcitabine Vinorelbine Vincristine Fluorourac Fl Etoposide Epir Be Y - u w SITE I isplatin etuximab armustine oxor ocetaxel actinomycin - r SAME u n e SITE COM n u e published guide published r THERAPEUTIC THERAPEUTIC d b o D p l l l N u d n u n i i i mycin arabine lastine U platin h taxel (Abraxane) taxel taxel b O amustine or b p u u a PLICATION alan icin i C icin N T T h b b l u D one l C os icin (Liposomal) icin icin l h b i R OMPATIBLE mus E o icin e U p i S l P h f G (5-FU) TED m A amide LI H TIBLE o N e t E h m e l i nes a r a t o p l y o S g Benda mustine Benda mustine e y q O u n Bevacizumab Bevacizumab e n c c o i l n o Bleo mycin Bleo mycin g g T1 y C ND ND ND ND ND , T h P Carbop latin C2 Carbop latin a h r a t r m Carmustine Carmustine R a c E y Cetuximab Cetuximab V G1 T1 P1 C1 I PD/T l N PD E , T T . , , DND C2 C2 C2 C2 C2 I2 w Cisplatin Cisplatin W w C1 T , w P2 P2 Cyc lopho spha mide Cyclopho spha mide A . S J e R S c F e H o 1,C2 PD c n T o O d n Cytarab ine Cytarab ine Chemotherapy Agent d I Chemotherapy Agent P C o L n Dacarba zine Dacarba zine E l i n e Dactino mycin Dactino myc in . c o m Dauno rub icin Dauno rub icin D1 D1 LD1-D2 I1 Dox 1 Dox P P ND ND NDND ND ND , K K T T , , T D2 /T /T Docetaxel V2 T2 Docetaxel D1 Dox 1 Dox P N K T , D /T Doxorub icin P2 Doxorub icin LD1-D2 LD1-V2 ND ND T Doxorub icin (Lipo somal) T Doxorub icin (Lipo somal) E1 P ND ND K , /T Epirub icin P2 Epirub icin M a ND r Etopo side Etopo side c h F1,C2 PD 2 Fluda rab ine Fluda rab ine 0 1 F1 L I1 PD/T 1 ND P PD 1 , , , D F2 M2 F2 F2 Fluo rou racil (5-FU) Fluo rou racil (5-FU) l G P1 P1 PD/T PD/T P 1 ND D/T V , . , G G Gemcitab ine C2 Gemcitab ine o 2 2 l 1 , Ida rub icin Ida rub icin N I1 o , T * D2 If osfamide If osfamide 1 C I1 PD/T ND ND P 1 , , D F2 Irino tecan I2 Irino tecan Ixabep il on e Ixabep il on e M1 L 1 PD PD , , F2 F2 Leu covorin L Leu covorin 2 Mechloretha mine Mechloretha mine V o l Melpha lan Melpha lan 1 , N Mesna * Mesna o F1 M 1 ND PD P 1 , , D M2 Metho trexate L Metho trexate 2 l M Mitomyc in Mitomycin a r c h Mitoxan tron e Mitoxan tron e 2 0 ND 1 Oxali platin Oxali platin 1 P1 D1 C1 P E1 PD/T P P 1 ND ND ND ND K K . T T . , , , G C2 C2 /T /T P2 P2 Pacli taxel P2 P2 Pacli taxel 2 Pacli taxel (Abraxane ) Pacli taxel (Abraxane ) C h Pan itumumab Pan itumumab S e S c e o e P1 c n PD/T m o d , n Chemotherapy Agent G d Pemetrexed Pemetrexed 2 Chemotherapy Agent o t w Pen tostatin Pen tostatin h w e w r a . Rituximab Rituximab J p H y O Strep tozocin Strep tozocin P A o d n Temsiroli mus Temsiroli mus m l i n D1 T T1 PK/T e 1 i ND , , T T n , . C2 C2 C2 C2 T2 T2 c Topo tecan Topo tecan i o s m t Trastuzumab Trastuzumab r a l t i J Vinb lastine Vinb lastine o o n u r n Vincristine Vincristine S a e l D1 LD1-V2 PK/T o q , T V2 V2 f Vino relbine Vino relbine u H e Flush w Avoid Avoid Avoid Avoid A m < 1hr< ith D5W ith <0.4 For e void g/ml n B B B l i m n e a a a s s Sod ium Chloride Sodium Chlor ide s s c e e e a Soluti Soluti Soluti m P P P P P e <0.4 t g/ml V V V V V o C C C C C l Dextrose 5% Wa ter Dex tro se 5% Wa ter o o o o Flush w D D D D D n n n ith D5W ith m g <0.4 s s s H H H H H g/ml l i y n EP EP EP EP EP e s La ctated Ringe rs Lactated Ringers O Vi Trastuzumab Temsiro Docetaxel Doxor Streptozocin Rituximab Pentostatin Pemetrexed Panitumumab Da Dactinomycin Pac Oxa Mitoxantrone Mitomycin Methotrexate Cyclo Cisplatin Dacarbazine Cytarabine Mel Cetuximab Mechlorethamine Leucovorin Carmustine Ixabep Topotecan Pac Mesna Irinotecan Ifosfamide Doxor Bl Carboplatin Bevacizumab Gemcitabine Idar Fluorourac Etoposide Epir Be Fl Vinorelbine Vincristine n PD= P u n e c n u d B b o S Y p l l l u d n u i o i i mycin arabine lastine - platin h taxel taxel (Abraxane) taxel PK= P PK= b A amustine or b SITE u p u I E LEGEND h N alan N l icin i icin b N h b a o l u SE LEGENDSE D COMPATIBLE one icin (Liposomal) icin r V O os QUE icin l b m = No di i g A T= Toxicity T T mus Y C icin acody h RIABLE p - i y a O SITE l h (5-FU) r E M m amide S P P acoki TED f n f A er a N h TIBLE mic/E e n a n C c e e r tic m f E f ica a c t n e g A y p a r e h t o m e h C t s r i F y c y 2 1.
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