DOCSLIB.ORG

Hyperemesis Gravidarum: Strategies to Improve Outcomes

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Hyperemesis Gravidarum: Strategies to Improve Outcomes The Art and Science of Infusion Nursing Hyperemesis Gravidarum Strategies to Improve Outcomes 03/11/2020 on //7dIgeiLuhMkL9kWvKwgfAPGFMPj02nltGDDFVobkWqncHWQRlSg9yjBWU9jBuwQSAQCN6yy/R8eEgzReezmPfm5ALSU3NvEsywdL7iOhefmPs35WVNSjdaQz7H5GI7 by http://journals.lww.com/journalofinfusionnursing from Downloaded Downloaded Kimber Wakefield MacGibbon, BSN, RN from http://journals.lww.com/journalofinfusionnursing ABSTRACT Hyperemesis gravidarum (HG) is a debilitating and potentially life-threatening pregnancy disease marked by weight loss, malnutrition, and dehydration attributed to unrelenting nausea and/or vomiting; HG increases the risk of adverse outcomes for the mother and child(ren). The complexity of HG affects every aspect of a woman’s life during and after pregnancy. Without methodical intervention by knowledgeable and proactive clinicians, life-threatening complications may develop. Effectively managing HG requires an understanding of both physical and psychosocial by //7dIgeiLuhMkL9kWvKwgfAPGFMPj02nltGDDFVobkWqncHWQRlSg9yjBWU9jBuwQSAQCN6yy/R8eEgzReezmPfm5ALSU3NvEsywdL7iOhefmPs35WVNSjdaQz7H5GI7 stressors, recognition of potential risks and complications, and proactive assessment and treatment strategies using innovative clinical tools. Key words: antiemetic, enteral nutrition, genetics, granisetron, HELP score, hyperemesis gravidarum, intravenous, malnutrition, nausea, neurodevelopmental disorder, ondansetron, parenteral nutrition, pregnancy, premature delivery, total parenteral nutrition, vomiting, vomiting center, Wernicke’s encephalopathy, Zofran ausea and vomiting of pregnancy (NVP) affects midpregnancy in half of women; however, HG persists at least 70% of women globally, whereas severe until delivery in nearly 22%.7-9 Nausea lasts all day in most NVP, or hyperemesis gravidarum (HG), reportedly women and causes debility and malnutrition because of its affects 0.5% to 14% of women across all ethnicities severity and poor response to medications. Emesis may be Nand socioeconomic levels.1-3 Because of inconsistent diag- episodic and triggered by stimuli such as motion, smells, nostic criteria, the actual incidence is unknown yet signifi- or the thought of food.8-10 Unlike emesis attributed to food cant, given that 18% of women take antiemetics for NVP.1,4 poisoning, emesis because of HG rarely brings relief, and the In addition, some women choose therapeutic termination emetic impulse may be so forceful and continuous that oral before being diagnosed or hospitalized.5 HG is the leading intake is impossible. Some women lose consciousness and cause of hospitalization in early pregnancy and second only bladder function. Severe cases may experience extensive to premature labor as the most common cause of hospital- dental damage, organ damage, encephalopathy, esophageal ization throughout all of pregnancy.6 rupture, pneumomediastinum, and retinal hemorrhage.11-14 The onset of HG typically occurs between 4 and Poor intake causes debility and profound fatigue, which 6 weeks, peaks around 10 and 13 weeks, and resolves by impairs self-care that often continues postpartum.8,10,14 About 80% of women lose weight, use medications, Author Affiliation: Hyperemesis Education and Research and have HG every pregnancy, whereas 67% receive intra- Foundation, Clackamas, Oregon. venous (IV) treatment and only 39% are hospitalized.15 Kimber Wakefield MacGibbon, BSN, RN, is the executive director Recurrence rates exceed 70%, although women proactively and cofounder of the Hyperemesis Education and Research (HER) on manage symptoms to avoid the traumatic experience of 03/11/2020 Foundation. For 20 years, she has consulted on hyperemesis grav- 16-20 idarum cases, developed clinical tools and educational materials for hosptialization. About 30% of women report that their clinicians and families, and coauthored more than 24 peer-reviewed symptoms in future pregnancies are the same, 26% say research studies with leading universities. symptoms are worse, and 44% report better pregnancies.15 The author of this article has no conflicts of interest to disclose. Maternal quality of life is severely altered by HG; thus, pro- Supplemental digital content is available for this article. Direct URL active and compassionate intervention is imperative.10,21,22 citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s website (http://journals.lww.com/journalofinfusionnursing). CLINICAL CHARACTERISTICS Corresponding Author: Kimber MacGibbon, BSN, RN, 10117 SE Sunnyside Road, Suite F8, Clackamas, OR 97015 (kimber@ hyperemesis.org). NVP is a spectrum from mild or morning sickness, to severe, DOI: 10.1097/NAN.0000000000000363 or HG. In between are women suffering with symptoms not 78 Copyright © 2020 Infusion Nurses Society Journal of Infusion Nursing Copyright © 2020 Infusion Nurses Society. Unauthorized reproduction of this article is prohibited. requiring hospitalization or nutritional intervention. They TABLE 1 continue some daily activities and maintain marginal intake and hydration, so they are often dismissed until symptoms Differential Diagnosis are severe. Objective signs and symptoms of moderate NVP are challenging to distinguish, yet aggressive intervention Gastrointestinal Genitourinary Metabolic and Gastroenteritis Pyelonephritis Endocrine may help prevent progression (Figure 1). Gastroparesis Uremia Diabetic ketoacidosis HG typically presents with nausea, vomiting, retching, Intestinal Ovarian torsion Porphyria weight loss, hyperolfaction, ptyalism, abdominal pain, obstruction Kidney stones Addison’s disease debility, gastroesophageal reflux, gastroparesis, electrolyte Peptic ulcer Uterine Thyroid disease 23,24 disease leiomyoma deficiency, malnutrition, and dehydration. About 25% Helicobacter of women lose 15% or more of their preconception weight pylori and are much more likely to have prolonged symptoms, Pancreatitis gallbladder and liver dysfunction, and retinal hemor- Appendicitis rhage.8 Although significant weight loss and ketonuria are Miscellaneous Neurologic PG Complications common, they are not reliable diagnostic criteria for HG.25 Drug toxicity Pseudotumor Acute fatty liver Infection cerebri Preeclampsia Proactive antiemetics may reduce weight loss and patient Migraines distress. CNS tumor Abbreviations: CNS, central nervous system; PG, pregnancy. DIFFERENTIAL DIAGNOSIS migraines, thyroid disease, high-fat diet, vegetarian/lac- 7,14,26,29-33 When a patient presents with NVP, determining possible tose-free diet, and gastrointestinal (GI) disorders. causes requires consideration of the timing. Nausea and Incidence increases slightly if mothers are carrying a child 30 vomiting beginning after 9 weeks’ gestation or refrac- that is female or has Down syndrome. However, the tory to medications requires an in-depth workup. Other predominant risk factor is a previous HG pregnancy or a conditions such as infections, hepatic and renal dysfunc- family member with HG. A woman has a 17-fold increased tion, intestinal obstruction, peptic ulcers, gastroenteri- risk if her sister has HG and a 27-fold risk if her mother 34 tis, thyrotoxicosis, gallbladder disease, and intracranial had it with both daughters. Some studies find HG risk lesions should be evaluated.23,26 Careful history-taking decreases in those with higher body mass index (BMI), is paramount, because HG has a multifactorial etiology. advanced age, and in those who smoke tobacco, which In addition, some disorders may develop secondary to could be attributed to reduced olfactory sensation or 29,35-37 dehydration and medications, worsening symptomatolo- decreased expression of placental proteins. Newer gy, so close monitoring is crucial until symptoms resolve research finds genetic evidence that overexpression of the 16 (Table 1).27,28 GDF15 risk allele is linked to recurrent HG. Multiple studies confirm that HG is not associated with pre-existing psychiatric diagnoses, including anxiety, depres- RISK FACTORS sion, bipolar disorder, or eating disorders.17,38-41 Rather, psy- chological sequelae are the result of prolonged symptoms, The risk factors for HG include multiple gestation, younger malnutrition, medications, and/or hospitalization and may age, first pregnancy, extreme high or low body weight, his- improve dramatically with resolution of HG. Psychological tory of motion sickness, allergies, premenstrual syndrome, support may lessen psychological sequelae, but a clinician’s focus should be on alleviating the misery of NVP. CONTRIBUTING FACTORS HG is complicated by secondary factors that may worsen symptoms but alone are not the cause of HG. For example, gallbladder dysfunction may worsen HG, but a cholecys- tectomy does not cure HG. Helicobacter pylori (H. pylori), present in about half of the world’s population, may be more prevalent in HG, possibly activated by changes in gut motility and gastric emptying, poor nutrition, and the hormonal and immunological changes of pregnancy.28,42-44 However, positive H. pylori tests do not reliably predict Figure 1 NVP spectrum. Abbreviations: EN, enteral nutrition; IV, intravenous; PN, parenteral nutrition; PO, oral or by mouth; Rx, the occurrence and severity of HG, its complications, or prescription medication. outcomes, and treating H. pylori may not resolve NVP.43,45-47 VOLUME 43 | NUMBER 2 | MARCH/APRIL 2020 journalofinfusionnursing.com 79 Copyright © 2020 Infusion Nurses Society. Unauthorized reproduction of this article is prohibited. Sensory sensitivity increases symptoms
Load more

Recommended publications
  • Routine Administration of Vitamin K1 Prophylaxis to the Newborn
    Routine Administration of Vitamin K1 Prophylaxis to the Newborn Practice Resource for Health Care Providers July 2016 Practice Resource Guide: ROUTINE ADMINISTRATION OF VITAMIN K1 PROPHYLAXIS TO THE NEWBORN The information attached is the summary of the position statement and the recommendations from the recent CPS evidence-based guideline for routine intramuscular administration of Vitamin K1 prophylaxis to the newborn*: www.cps.ca/documents/position/administration-vitamin-K-newborns Summary Vitamin K deficiency bleeding or VKDB (formerly known as hemorrhagic disease of the newborn or HDNB) is significant bleeding which results from the newborn’s inability to sufficiently activate vitamin K-dependent coagulation factors because of a relative endogenous and exogenous deficiency of vitamin K.1 There are three types of VKDB: 1. Early onset VKDB, which appears within the first 24 hours of life, is associated with maternal medications that interfere with vitamin K metabolism. These include some anticonvulsants, cephalosporins, tuberculostatics and anticoagulants. 2. Classic VKDB appears within the first week of life, but is rarely seen after the administration of vitamin K. 3. Late VKDB appears within three to eight weeks of age and is associated with inadequate intake of vitamin K (exclusive breastfeeding without vitamin K prophylaxis) or malabsorption. The incidence of late VKDB has increased in countries that implemented oral vitamin K rather than intramuscular administration. There are three methods of Vitamin K1 administration: intramuscular, oral and intravenous. The Canadian Paediatric Society (2016)2 and the American Academy of Pediatrics (2009)3 recommend the intramuscular route of vitamin K administration. The intramuscular route of Vitamin K1 has been the preferred method in North America due to its efficacy and high compliance rate.
    [Show full text]
  • Vitamin K for the Prevention of Vitamin K Deficiency Bleeding (VKDB)
    Title: Vitamin K for the Prevention of Vitamin K Deficiency Bleeding (VKDB) in Newborns Approval Date: Pages: NEONATAL CLINICAL February 2018 1 of 3 Approved by: Supercedes: PRACTICE GUIDELINE Neonatal Patient Care Teams, HSC & SBH SBH #98 Women’s Health Maternal/Newborn Committee Child Health Standards Committee 1.0 PURPOSE 1.1 To ensure all newborns are properly screened for the appropriate Vitamin K dose and route of administration and managed accordingly. Note: All recommendations are approximate guidelines only and practitioners must take in to account individual patient characteristics and situation. Concerns regarding appropriate treatment must be discussed with the attending neonatologist. 2.0 PRACTICE OUTCOME 2.1 To reduce the risk of Vitamin K deficiency bleeding. 3.0 DEFINITIONS 3.1 Vitamin K deficiency bleeding (VKDB) of the newborn: previously referred to as hemorrhagic disease of the newborn. It is unexpected and potentially severe bleeding occurring within the first week of life. Late onset VKDB can also occur in infants 2-12 weeks of age with severe vitamin k deficiency. Bleeding in both types is primarily gastro-intestinal and intracranial. 3.2 Vitamin K1: also known as phytonadione, an important cofactor in the synthesis of blood coagulation factors II, VII, IX and X. 4.0 GUIDELINES Infants greater than 1500 gm birthweight 4.1 Administer Vitamin K 1 mg IM as a single dose within 6 hours of birth. 4.1.1 The infant’s primary health care provider (PHCP): offer all parents the administration of vitamin K intramuscularly (IM) for their infant. 4.1.2 If parent(s) refuse any vitamin K administration to the infant, discuss the risks of no vitamin K administration, regardless of route, with the parent(s).
    [Show full text]
  • Gentle Prenatal It Is Appropriate for Pregnant Women to Supplement with a Conservative Dose of Iron
    product facts Gentle Prenatal It is appropriate for pregnant women to supplement with a conservative dose of iron. Multivitamin and Mineral Supplement with Iron and gentle prenatal Product Features Vitamin D3 and Choline Gentle Prenatal contains the same carefully designed combination of vitamins and minerals present in • 100% Vegan Dr. Fuhrman’s Women’s Daily Formula +D3, but is uniquely tailored to the needs of women who are pregnant or • 18 mg of Ferronyl® iron – designed to planning to become pregnant. Dr. Fuhrman knows it is be gentle on the digestive system imperative that young women protect their health and • 25 mcg (1000 IU) vegan vitamin D3 – the health of their children by avoiding conventional compared to 10 mcg (400 IU) in other supplements which have potentially harmful ingredients prenatal formulas that could negatively affect them. • Contains choline, a nutrient involved in fetal brain development What makes it unique? • Premium quality ingredients Contains 18 mg ferronyl iron important supplement for pregnant women – during the • Chelated minerals for maximum Women’s iron needs increase during pregnancy because third trimester, calcium demands increase and vitamin absorption of increased blood volume and the iron needs of the D is essential for calcium absorption and fetal bone developing baby–adequate iron stores are essential growth. The amount of vitamin D currently contained in • Void of potentially harmful and toxic for brain development and may also be important most prenatal vitamins (10 mcg [400 IU]) is inadequate ingredients 1-4 for mother-child bonding. However, excess iron – vitamin D deficiency is common, affecting up to 50% • Non-GMO and no gluten-containing 5 is also problematic.
    [Show full text]
  • Prenatal Vitamins
    Prenatal Vitamins Eating a healthy diet is always a wise idea – especially during pregnancy. It's a good idea during pregnancy to also take a prenatal vitamin to help cover any nutritional gaps in the mother's diet. Prenatal vitamins contain many vitamins and minerals. Their folic acid, iron, and calcium are especially important. Folic Acid, Iron, and Calcium Folic acid helps prevent neural tube birth defects, which affect the brain and spinal cord. Neural tube defects develop in the first 28 days after conception, before many women know they are pregnant. Because about half of all pregnancies are unplanned, it's recommended that any woman who could get pregnant take 800 micrograms (mcg) of folic acid daily, starting before conception and continuing for the first 12 weeks of pregnancy. A woman who has already had a baby with a neural tube defect should talk to her health care provider about whether she might need to take a different dose of folic acid. Studies have shown that taking a larger dose (up to 4,000 micrograms) at least one month before and during the first trimester may be beneficial for those women but check with your doctor first. Foods containing folic acid include green leafy vegetables, nuts, beans, citrus fruits, and many fortified foods. Even so, it's a good idea to take a supplement with the right amount of folic acid, as a backup. Calcium is also important for a pregnant woman. It can help prevent her from losing her own bone density, as the baby uses calcium for its own bone growth.
    [Show full text]
  • Vitamin K Information for Parents-To-Be
    Vitamin K Information for parents-to-be Maternity This leaflet has been written to help you decide whether your baby should receive a vitamin K supplement at birth. What is vitamin K? Vitamin K is needed for the normal clotting of blood and is naturally made in the bowel. page 2 Why is vitamin K given to newborn babies? All babies are born with low levels of vitamin K. Several days after birth, a baby will normally produce their own supply of vitamin K from natural bacteria found in their bowel. They can also get a small amount of vitamin K from their mother’s breast milk and it is added to formula milk. This can help the natural bacteria in the baby’s bowel to develop, which in turn improves their levels of vitamin K. However, babies are more at risk of developing vitamin K deficiency until they are feeding well. A deficiency in vitamin K is the main cause of vitamin K deficiency bleeding (VKDB). This can cause bleeding from the belly button, nose, surgical sites (i.e. following circumcision), and (rarely) in the brain. The risk of this happening is approximately 1 in 100,000 for full term babies. VKDB is a serious disorder, which may lead to internal bleeding. Signs of internal bleeding are: • blood in the nappy • oozing (bleeding) from the cord • nose bleeds • bleeding from scratches which doesn’t stop on its own • bruising • prolonged jaundice (yellowing of the skin) at three weeks if breast feeding and two weeks if formula feeding. VKDB can also lead to bleeding on the brain, which can cause brain damage and/or death.
    [Show full text]
  • Nutrition Guideline: Pregnancy: Multiples
    Nutrition Guideline For Professional Reference Only Pregnancy Applicable to: Nurses, Physicians and Other Health Professionals Recommendations: • Women who could become pregnant are encouraged: o To eat a variety of food every day and make healthy eating and physical activity part of everyday life. o To take a multivitamin and mineral supplement that contains 0.4 mg (400 mcg) of folic acid every day. Women are recommended to start supplementation at a minimum of 3 months prior to conception. o To maintain a healthy body weight before and between pregnancies. • During pregnancy, women are advised to: o Eat a variety of foods and follow Canada’s Food Guide. o Include additional foods every day in the 2nd and 3rd trimesters of pregnancy in amounts appropriate to meet healthy pregnancy weight gain recommendations for their pre-gravid BMI category. o Choose a multivitamin and mineral supplement that contains 0.4 mg (400 mcg) folic acid, 16 – 20 mg of iron, vitamin B12, and 400 IU of vitamin D every day. o Follow safe food handling practices and avoid foods that increase chances of getting a food-borne illness during pregnancy. o Limit caffeine intake to 300 mg per day. o Drink 10 cups (2.5 L) of fluid each day. Water is recommended as the main fluid. • Health care providers are advised to provide pregnant women with nutrition information that will help them make informed choices about: o Healthy pregnancy weight gain. o Nutrients of special concern during pregnancy (e.g. folic acid, iron, calcium). o Nutrient supplements. o Beverage and fluid choices.
    [Show full text]
  • Vitamin K for Newborn Babies: Information for Parents
    Vitamin K for Newborn Babies Information for parents This leaflet explains what vitamin K is, and its importance in preventing bleeding problems in newborn babies. We hope it gives you enough information to help you make an informed choice about this part of your baby’s care. What is vitamin K? Vitamin K occurs naturally in food (especially red meat and some green vegetables). It is also produced by friendly bacteria in our gut. We all need it as it helps to make our blood clot and to prevent bleeding problems. Newborn babies and young infants have very little vitamin K. How do low levels of Vitamin K affect a newborn baby? A very small number of babies suffer bleeding problems due to a shortage of vitamin K. This is called Vitamin K Deficiency Bleeding (or VKDB for short). The classical form usually happens in the first week of life. The baby may bleed from the mouth or nose or from the stump of the umbilical cord. Late onset VKDB is a more serious problem which happens after the baby is about three weeks old. The bleeding is sometimes into the gut or the brain and in some cases it can cause brain damage or even death. How can Vitamin K Deficient Bleeding be prevented? The Scottish Government recommends that all newborn babies are given vitamin K to reduce the chances of dangerous internal bleeding. The most effective treatment is a single dose of vitamin K injected into the thigh muscle shortly after birth. Vitamin K by mouth is also effective in most cases but your baby will need to have a number of doses through the first 1-3 months of life.
    [Show full text]
  • Iron Supplement
    What you need to know if your physician has recommended an extra iron supplement Iron Iron is a mineral that is stored primarily in your liver, but it's also stored in your bone marrow, spleen and muscles. Iron is essential because it helps your red blood cells (RBC) carry and deliver oxygen to other parts of your body, as well as aiding in energy production. Iron is another nutrient that pregnant women need more of. This is due to the increased volume of blood supply during pregnancy to accommodate a woman's unborn child. Women already have an increased need for iron because of menstrual periods; pregnancy just adds to this need. Supplements Depending upon the type of supplement you're considering, you may find iron (Slow Fe) and folic acid (Folate) in a multi‐blend or as individual supplements. Almost any drug store or retail store will carry multivitamins, prenatal vitamins and individual supplements. It's very important that you do not rely on the supplement alone to supply your need for a particular vitamin or mineral as they are merely a supplement to your daily food intake. They are not meant to supply your daily needs on a regular basis. Supplements only help complete your daily recommended allowance if you do not get enough of them during the day. Recommended Dosage During normal pregnancy, the recommended intake of iron is 27 milligrams (mg) a day. Women between the ages of 19 and 50 who aren't pregnant need only 18 mg a day, and women age 51 and older and all adult men need around 8 mg a day.
    [Show full text]
  • PRENATAL- Vitamin A, Ascorbic Acid, Cholecalciferol, .Alpha
    PRENATAL- vitamin a, ascorbic acid, cholecalciferol, .alpha.-tocopherol, thiamine, riboflavin, niacin, pyridoxine, folic acid, cyanocobalamin, calcium, ferrous fumarate, and zinc oxide tablet Central Texas Community Health Centers ---------- Prenatal Tablets Supplement Facts Serving Size: 1 Tablet % Daily Amount Per Serving Value* 4000 Vitamin A (as Acetate and Beta Carotene) 50% I.U. 100 Vitamin C (as Ascorbic Acid) 167% mg. 400 Vitamin D-3 (as Cholecalciferol) 100% I.U. Vitamin E (as dl-Alpha Tocopheryl Acetate) 11 I.U. 37% Vitamin B-1 (as Thiamine Mononitrate) 1.5 mg. 88% Vitamin B-2 (Riboflavin) 1.7 mg. 85% Vitamin B-3 (as Niacinamide) 18 mg. 90% Vitamin B-6 (as Pyridoxine HCl) 2.6 mg. 104% Folic Acid 0.8 mg. 100% Vitamin B-12 (as Cyanocobalamin) 4 mcg. 50% Calcium (as Calcium Carbonate and Calcium Sulfate) 263 mg. 26% Iron (as Ferrous Fumarate) 27 mg. 150% Zinc (as Zinc Oxide) 25 mg. 167% * % Daily Value for Pregnant and Lactating Women OTHER INGREDIENTS: Microcrystalline Cellulose, Stearic Acid, Hypromellose, Croscarmellose Sodium, Gelatin, Acacia, Maltodextrin, Titanium Dioxide, Talc, Triacetin, Starch, Magnesium Stearate, Dicalcium Phosphate, Mineral Oil, Sucrose, Silica, Sodium Ascorbate, Triglycerides, FD&C Red #40 Lake, FD&C Yellow #6 Lake, Tocopherols, Sodium Benzoate, Sorbic Acid, Tricalcium Phosphate, BHT and Ascorbyl Palmitate. DIRECTIONS For adults, take one (1) tablet daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers. WARNING If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.
    [Show full text]
  • Vitamin K1 (Phytomenadione) 2021 Newborn Use Only
    Vitamin K1 (Phytomenadione) 2021 Newborn use only Alert Check ampoule carefully as an adult 10 mg ampoule (Konakion MM Adult) is also available. USE ONLY Konakion MM Paediatric. Vitamin K Deficiency Bleeding is also known as Haemorrhagic Disease of Newborn (HDN) Indication Prophylaxis and treatment of vitamin K deficiency bleeding (VKDB) Action Fat soluble vitamin. Promotes the activation of blood coagulation Factors II, VII, IX and X in the liver. Drug type Vitamin. Trade name Konakion MM Paediatric. Presentation 2 mg/0.2 mL ampoule. Dose IM prophylaxis (Recommended route)(1) Birthweight ≥ 1500 g - 1 mg (0.1 mL of Konakion® MM) as a single dose at birth. Birthweight <1500 g - 0.5 mg (0.05 mL of Konakion® MM) as a single dose at birth. Oral prophylaxis(1) 2 mg (0.2 mL of Konakion® MM) for 3 doses: • First dose: At birth. • Second dose: 3–5 days of age (at time of newborn screening) • Third dose: During 4th week (day 22-28 of life). • It is imperative that the third dose is given no later than 4 weeks after birth as the effect of earlier doses decreases after this time. • Repeat the oral dose if infant vomits within an hour of an oral dose or if diarrhoea occurs within 24 hours of administration. IV Prophylaxis (5) May be given in sick infants if unable to give IM or oral injection. 0.3 mg/kg (0.2-0.4 mg/kg) as a single dose as a slow bolus (maximum 1 mg/minute). Dose can be repeated weekly. IV treatment of Vitamin K deficiency bleeding (VKDB) 1 mg IV as a slow bolus (maximum 1 mg/minute).
    [Show full text]
  • Supplements for Women Planning Pregnancy, Pregnant Women and Breastfeeding Women
    SUPPLEMENTS FOR WOMEN PLANNING PREGNANCY, PREGNANT WOMEN AND BREASTFEEDING WOMEN Pregnancy: Prenatal Vitamins . Prenatal vitamins are specially formulated multivitamins that mothers-to-be are advised to take for their own health as well as for the health of their babies. Taking folic acid can reduce your risk of having a baby with a serious birth defect of the brain and spinal cord, called the "neural tube." . A baby with spina bifida, the most common neural tube defect, is born with a spine that is not completely developed. The exposed nerves are damaged, leaving the child with varying degrees of paralysis, incontinence, and sometimes mental retardation. These vitamins make up for most nutritional deficiencies in your diet during pregnancy. Prenatal vitamins are specially formulated multivitamins that mothers-to-be are advised to take for their own health as well as for the health of their babies. These vitamins make up for any nutritional deficiencies in your diet during your pregnancy. he supplements contain numerous vitamins and minerals, folic acid, iron. Calcium should be taken separately since adequate amounts are not present in PNV. Why do pregnant women need high levels of folic acid, iron, and calcium? Folic Acid Folic acid is an essential nutrient to take at least one month before attempting to become pregnant because of its role in preventing neuro tube defects (NTD). Taking adequate amounts of folic acid before and during pregnancy may help decrease the risk of: neural tube defects congenital heart defects cleft palate cleft lip You should take 400-800 micrograms of folic acid every day for at least one month before pregnancy and continue until 12 weeks pregnant.
    [Show full text]
  • Pregnancy & Prenatal Care
    Indian Health Service National Pharmacy and Therapeutics Committee Formulary Brief: Pregnancy & Prenatal Care -April 2021- Background: At the Spring 2021 meeting, the Indian Health Service National Pharmacy and Therapeutics Committee (NPTC) provided a review of current guidelines and clinical recommendations for prenatal care as well as an analysis of evidence-based therapies for use in pregnant patients. Currently named medications to the National Core Formulary include folic acid, pyridoxine, vitamin D, iron, and aspirin. Following review and evaluation, the NPTC voted to ADD prenatal multivitamins (containing ≥400 mcg of folic acid/dose) to the National Core Formulary. Discussion: Due to increased metabolic demands for fetal growth and development, pregnant women are particularly vulnerable to numerous vitamin and mineral deficiencies including but not limited to: iron, vitamin D, folate, vitamin A, iodine, zinc, calcium, and vitamin B12. Iron deficiency is the most common known form of nutritional deficiency and is most prevalent among young children and women of childbearing age, particularly pregnant women. Anemia during the first two trimesters of pregnancy is associated with two-fold increased risk for preterm delivery and three-fold increased risk for delivering a low-birthweight baby1. Meta-analyses of 43 studies found that overall, women taking oral iron supplementation were less likely to have low birthweight newborns compared with no iron (RR 0.81; 95% CI, 0.68 to 0.97; based on 11 trials) and lower rates of maternal anemia (RR 0.30; 95% CI, 0.19 to 0.46) and iron deficiency (RR 0.43; 95% CI, 0.27 to 0.66) during pregnancy2,3.
    [Show full text]