Uva-DARE (Digital Academic Repository)

UvA-DARE (Digital Academic Repository)

Complex evolutionary dynamics of massively expanded chemosensory receptor families in an extreme generalist chelicerate herbivore

Ngoc, P.C.T.; Greenhalgh, R.; Dermauw, W.; Rombauts, S.; Bajda, S.; Zhurov, V.; Grbić, M.; Van de Peer, Y.; Van Leeuwen, T.; Rouzé, P.; Clark, R.M. DOI 10.1093/gbe/evw249 Publication date 2016 Document Version Other version Published in Genome Biology and Evolution

Link to publication

Citation for published version (APA): Ngoc, P. C. T., Greenhalgh, R., Dermauw, W., Rombauts, S., Bajda, S., Zhurov, V., Grbić, M., Van de Peer, Y., Van Leeuwen, T., Rouzé, P., & Clark, R. M. (2016). Complex evolutionary dynamics of massively expanded chemosensory receptor families in an extreme generalist chelicerate herbivore. Genome Biology and Evolution, 8(11), 3323-3339. https://doi.org/10.1093/gbe/evw249

General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons).

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)

Download date:30 Sep 2021 99 TuGR2 (tetur06g01480) Clade C 93 TuGR3 (tetur07g04370) (n = 7)

86 TuGR1 (tetur19g02720) Clade A TuGR543 (tetur11g06470) (n = 188) TuGR5 (tetur11g00460) 80 Clade B (n = 252) 43 TuGR511 (tetur05g08450) 32 TuGR510 (tetur11g00450)

98 TuGR258 (tetur01g16854) TuGR257 (tetur01g16734) 100 TuGR262 (tetur12g04913)

86 TuGR259 (tetur01g16784) 89 TuGR260 (tetur01g16844) 88 TuGR261 (tetur01g16864)

100 TuGR268 (tetur16g03996) 34 TuGR269 (tetur16g04006) TuGR266 (tetur16g04096) 100 45 TuGR265 (tetur16g03916) 7 52 TuGR673 (tetur144g00006) 100 TuGR264 (tetur16g04106) TuGR263 (tetur16g03956)

246141 TuGR670 (tetur144g00003) TuGR267 (tetur16g03976) TuGR270 (tetur16g03966) 97 TuGR271 (tetur16g04086) 70 100 TuGR669 (tetur144g00002) 68 67 TuGR272 (tetur16g03986) TuGR275 (tetur16g04056)

100 TuGR274 (tetur16g04066) 88 TuGR273 (tetur16g04046) TuGR483 (tetur21g03400) 39 TuGR279 (tetur21g03350)

98 TuGR276 (tetur21g03360) 9754 TuGR277 (tetur21g03380) 82 65 TuGR278 (tetur21g03370) 100 TuGR281 (tetur21g03390) TuGR280 (tetur04g09587)

90 TuGR282 (tetur07g04980) TuGR283 (tetur07g05040)

24 TuGR286 (tetur07g04990) 37 100 TuGR287 (tetur07g08107) 25 45 TuGR288 (tetur07g05030) TuGR285 (tetur07g08097) 10 100 50 TuGR284 (tetur07g08117) 7 TuGR289 (tetur07g05000) TuGR290 (tetur01g16834) 17 TuGR295 (tetur03g04270) TuGR292 (tetur03g07910) 54 35 TuGR293 (tetur03g07800)

91 TuGR296 (tetur02g08860) TuGR291 (tetur13g04726) TuGR294 (tetur31g02042) 49 TuGR302 (tetur12g00130) 53 TuGR298 (tetur02g14350) 100 TuGR297 (tetur02g14340)

100 84 TuGR300 (tetur12g00160) TuGR299 (tetur12g00150) 68 TuGR301 (tetur12g00170) TuGR367 (tetur08g08200) 56 TuGR369 (tetur08g00800) 100 70 TuGR370 (tetur08g00790) 74 TuGR368 (tetur08g08230) TuGR366 (tetur12g01060)

97 TuGR356 (tetur14g01260)

100 TuGR355 (tetur14g01250) TuGR354 (tetur14g01230) 82 65 TuGR357 (tetur14g01240)

76 TuGR352 (tetur08g00840) TuGR361 (tetur08g00860)

63 TuGR358 (tetur08g00870) 85 100 TuGR359 (tetur08g00910) 85 100 TuGR360 (tetur08g00880) TuGR365 (tetur08g00770) TuGR363 (tetur08g08110) 99 TuGR364 (tetur08g08130) 75 100 TuGR338 (tetur02g06690)

57 TuGR339 (tetur20g03320) 78 TuGR340 (tetur02g06710) 99 43 TuGR341 (tetur02g06780)

100100 TuGR346 (tetur02g06830) TuGR347 (tetur02g06860) 89 100 TuGR344 (tetur02g06800) TuGR345 (tetur02g15227) 100 56 81 TuGR348 (tetur02g06840) TuGR342 (tetur02g06760) 94 TuGR343 (tetur02g06810) 100 TuGR349 (tetur08g00530) 99 TuGR350 (tetur08g00540) TuGR351 (tetur40g00402)

46 TuGR324 (tetur08g08150) 100 42 TuGR325 (tetur08g08265) TuGR328 (tetur08g01070) 100 TuGR329 (tetur08g01090) 86 100 TuGR327 (tetur08g08100) TuGR326 (tetur08g01080)

74 63 TuGR319 (tetur02g06740) 43 TuGR318 (tetur02g06750)

79 TuGR323 (tetur02g06870) 100 TuGR322 (tetur02g06820)

98 TuGR316 (tetur02g06720) 30 TuGR315 (tetur02g06680) 100 TuGR321 (tetur02g06770) 6752 TuGR320 (tetur02g15237) 95 99 TuGR317 (tetur02g06730) TuGR334 (tetur08g00750) 95 74 TuGR330 (tetur08g08170) TuGR331 (tetur08g08220) 100 TuGR333 (tetur46g00120) 100 100 TuGR332 (tetur11g05510) TuGR337 (tetur08g00780)

100 TuGR335 (tetur08g08160) 89 TuGR336 (tetur08g08210) TuGR387 (tetur01g16754) 34 32 TuGR374 (tetur09g02320) TuGR371 (tetur09g02300) 100 TuGR373 (tetur09g02310) 90 TuGR372 (tetur167g00020)

79 TuGR385 (tetur18g03831) 94 TuGR384 (tetur18g03811) 100 TuGR383 (tetur18g03731) 47 98 TuGR386 (tetur18g03751) TuGR381 (tetur18g03721) 100 TuGR382 (tetur18g03761)

51 TuGR388 (tetur18g03470)

33 TuGR390 (tetur18g03821)

100 TuGR394 (tetur18g03741) 94 TuGR644 (tetur305g00020) 100 84 TuGR393 (tetur18g03801)

9084 TuGR395 (tetur18g03480) 26 TuGR391 (tetur18g03771) 100 TuGR392 (tetur18g03791) 58 100 TuGR398 (tetur18g03781) TuGR397 (tetur17g00720) 100 59 TuGR400 (tetur17g00730) 100 TuGR399 (tetur01g16744) TuGR396 (tetur18g03841) TuGR379 (tetur09g06819) 100 TuGR378 (tetur09g06799)

22 100 TuGR689 (tetur371g00001)

67 TuGR377 (tetur09g06809) TuGR376 (tetur09g03660) 45 100 TuGR375 (tetur09g03640) TuGR380 (tetur13g04716)

100 TuGR240 (tetur66g00010) 100 TuGR239 (tetur12g04020) 49 TuGR241 (tetur66g00090) TuGR237 (tetur12g04823) 12 TuGR232 (tetur12g04783)

43 TuGR230 (tetur12g04010) 15 TuGR238 (tetur12g04843) 62 17 TuGR242 (tetur12g04090) 63 TuGR245 (tetur12g04803) TuGR236 (tetur12g04853) 59 TuGR235 (tetur12g04833) 10078 98 TuGR233 (tetur12g04893) 98 TuGR234 (tetur66g00120)

100 TuGR243 (tetur12g04773) 100 TuGR642 (tetur265g00001) 100 TuGR244 (tetur12g04793)

48 TuGR248 (tetur12g04703) TuGR249 (tetur12g04753) 71 TuGR247 (tetur34g00410) 96 100 TuGR246 (tetur34g00400)

69 TuGR227 (tetur12g01690) TuGR224 (tetur12g01680)

100 84 TuGR223 (tetur12g04661) 77 TuGR222 (tetur12g01660)

100 TuGR226 (tetur12g01670) 68 99 TuGR225 (tetur12g04903) 84 TuGR229 (tetur27g01820) 100 TuGR228 (tetur12g04743)

100 TuGR220 (tetur12g04763)

62 TuGR221 (tetur35g00340) TuGR218 (tetur34g00390) 91 100 TuGR217 (tetur12g00810) 100 TuGR219 (tetur06g05120) TuGR309 (tetur25g02112) TuGR305 (tetur14g01040)

100 TuGR306 (tetur19g01180) 100 53 TuGR307 (tetur19g01190) 27 TuGR303 (tetur07g04200) 100 TuGR304 (tetur14g00940) 66 58 TuGR308 (tetur13g04736) TuGR528 (tetur04g06520)

99 TuGR311 (tetur15g00440) TuGR310 (tetur06g06711) TuGR313 (tetur398g00010) 100 72 TuGR312 (tetur15g00420) 98 100 TuGR314 (tetur15g00430)

81 TuGR250 (tetur14g02850) 100 TuGR251 (tetur37g00370) TuGR252 (tetur13g04410) 42 TuGR253 (tetur06g05440)

100 TuGR255 (tetur13g00950) TuGR254 (tetur01g16774) 57 TuGR256 (tetur24g00910)

100 TuGR4 (tetur02g09560) TuGR216 (tetur05g00780) TuGR182 (tetur05g03560) 100 82 TuGR179 (tetur05g09335) TuGR180 (tetur05g09345) 100 TuGR181 (tetur05g04830) TuGR122 (tetur02g00190) 45 TuGR115 (tetur07g01770) 100 33 TuGR116 (tetur07g01820) TuGR124 (tetur02g08930) TuGR552 (tetur131g00050) 51 TuGR119 (tetur19g02670) 78 TuGR117 (tetur131g00010) 10044 97 TuGR118 (tetur19g02630) TuGR464 (tetur131g00030) 43 TuGR120 (tetur19g02610) TuGR123 (tetur02g15287) TuGR143 (tetur17g03090)

25 TuGR141 (tetur17g03980) 100 TuGR139 (tetur17g03020) 68 TuGR135 (tetur17g02940) 64 92100 TuGR144 (tetur17g03060) TuGR134 (tetur17g03050) 92 TuGR140 (tetur17g03080) 24 90 TuGR142 (tetur17g02980) TuGR138 (tetur17g03000) 53 40 99 TuGR137 (tetur17g03070) 89 TuGR136 (tetur17g02990) TuGR133 (tetur11g05240)

100 TuGR163 (tetur24g02697) TuGR596 (tetur17g04210) 90 TuGR580 (tetur17g04040)

100 TuGR582 (tetur17g04060) 95 100 TuGR629 (tetur24g02877) 49 TuGR579 (tetur17g04030)

100 TuGR577 (tetur17g04010) TuGR630 (tetur24g02887) 73 100 TuGR575 (tetur17g00040) 100 TuGR621 (tetur24g02787)

100 TuGR164 (tetur24g02707) TuGR587 (tetur17g04110) TuGR584 (tetur17g04080) 100 100 TuGR586 (tetur17g04100) 100 23 TuGR585 (tetur17g04090) 61 TuGR628 (tetur24g02867) 55 TuGR165 (tetur24g02717) 100 TuGR166 (tetur19g00260) TuGR632 (tetur24g02917) 100 100 TuGR597 (tetur17g04220) TuGR634 (tetur24g02937) 74 TuGR592 (tetur17g04170) 83 57 TuGR624 (tetur24g02827)

100 TuGR162 (tetur24g02757) TuGR590 (tetur17g04150)

100 TuGR591 (tetur17g04160) 47 83 TuGR161 (tetur24g02747) TuGR581 (tetur17g04050) 96 100 TuGR160 (tetur24g02737) 100 TuGR574 (tetur17g00010) 59 97 TuGR620 (tetur24g02777)

56 TuGR588 (tetur17g04120)

100 TuGR622 (tetur24g02797) 91 TuGR594 (tetur17g04190) 54 TuGR623 (tetur24g02807) 53 100 TuGR593 (tetur17g04180)

100 TuGR151 (tetur13g04600) 12 TuGR659 (tetur85g00003)

100 TuGR146 (tetur13g04580) 100 TuGR145 (tetur13g04560)

41100 TuGR147 (tetur13g01070) TuGR150 (tetur13g04590)

76 TuGR148 (tetur13g04570) 100 TuGR149 (tetur13g04670)

100 TuGR658 (tetur85g00002) 30 TuGR152 (tetur13g04620) 37 TuGR155 (tetur13g04650) 100 71 TuGR565 (tetur150g00001) 100 TuGR156 (tetur13g04660) 27 92 TuGR157 (tetur13g01100)

71 TuGR657 (tetur85g0000) TuGR154 (tetur13g04640) 100 TuGR153 (tetur13g04630)

57 TuGR128 (tetur10g05340) TuGR129 (tetur14g02630)

100 TuGR126 (tetur02g04200) 100 100 TuGR125 (tetur02g04180) TuGR127 (tetur19g01600) TuGR131 (tetur22g00910) 90 93 TuGR130 (tetur22g00920) 98 100 TuGR544 (tetur121g00010) 100 TuGR546 (tetur121g00030) 79 TuGR132 (tetur22g00930) TuGR170 (tetur02g02230) TuGR168 (tetur17g01070) 99 100 TuGR167 (tetur17g01060) 85 TuGR169 (tetur17g01210) 99 TuGR111 (tetur28g00180)

100 TuGR81 (tetur33g01020) TuGR82 (tetur33g01030) 86 TuGR80 (tetur33g00980)

97 TuGR76 (tetur11g06380) 100 TuGR77 (tetur33g01000) 71 TuGR78 (tetur33g00990) 69 51 TuGR79 (tetur33g01010) 100 TuGR85 (tetur32g02190) 100 TuGR86 (tetur33g00100)

36 TuGR83 (tetur32g02210) 82 85 TuGR84 (tetur33g00070) TuGR89 (tetur33g00140) 72 TuGR87 (tetur33g00130) 66 TuGR88 (tetur33g00150) 9998 100 TuGR90 (tetur33g00090) TuGR91 (tetur33g00010) 80 TuGR92 (tetur33g00110) TuGR73 (tetur44g00080) 100 TuGR74 (tetur44g00110) 55 TuGR75 (tetur44g00090) TuGR72 (tetur01g14970) 100 93 48 TuGR70 (tetur01g14950) 89 TuGR71 (tetur01g16694)

100 TuGR69 (tetur01g14900) TuGR64 (tetur01g14820) 100 100 TuGR63 (tetur01g14830) 72 TuGR65 (tetur01g16614) 55 TuGR66 (tetur01g14840)

100 TuGR68 (tetur01g14880) 100 TuGR67 (tetur01g14870) TuGR112 (tetur44g00271) 75 49 100 TuGR93 (tetur04g02560) TuGR94 (tetur04g02570)

100 TuGR98 (tetur17g00070) 100 TuGR95 (tetur17g00030) 100 TuGR96 (tetur24g02550) 100 TuGR97 (tetur17g00060) 69 25 100 TuGR100 (tetur119g00010) 100 TuGR99 (tetur04g03360) TuGR101 (tetur19g02640) TuGR108 (tetur05g07870)

100 TuGR107 (tetur04g05610)

56 TuGR105 (tetur04g05530) 75 TuGR655 (tetur629g00010) 100 TuGR103 (tetur04g05500) 29 56 TuGR102 (tetur04g05470) 67 53 95 TuGR104 (tetur04g09504) TuGR106 (tetur04g05590) TuGR109 (tetur24g00240) 100 TuGR110 (tetur24g00260) TuGR113 (tetur19g02650) 100 TuGR114 (tetur19g02700) TuGR529 (tetur04g09618) TuGR196 (tetur04g04090) 73 100 TuGR195 (tetur04g04120) 71010 TuGR194 (tetur04g04070) TuGR198 (tetur04g04080)

100 TuGR193 (tetur04g04020) 76 100 90 TuGR197 (tetur04g04060) TuGR199 (tetur16g02540)

89 TuGR207 (tetur17g00270) TuGR209 (tetur17g00340) 98 59 TuGR203 (tetur17g00260) TuGR206 (tetur17g00320) 99 100 63 TuGR205 (tetur10g05450) 100 TuGR204 (tetur10g05440) 48 TuGR202 (tetur17g00250) 92 100 TuGR201 (tetur04g02860) TuGR184 (tetur04g09577) 74 TuGR648 (tetur373g00010) 100 100 86 TuGR187 (tetur04g01320) TuGR186 (tetur04g01310) 84 TuGR183 (tetur04g01350) 7654 54 TuGR185 (tetur04g01360) TuGR189 (tetur20g02820) 100 TuGR188 (tetur20g02810) TuGR200 (tetur310g00010) TuGR192 (tetur24g02670) 61 100 TuGR191 (tetur17g00130) 31 73 TuGR190 (tetur17g00110)

100 TuGR177 (tetur03g08930) TuGR176 (tetur03g08920) 100 TuGR175 (tetur03g08910) TuGR174 (tetur03g08990) 99 55 TuGR172 (tetur03g08960) 75 100 TuGR173 (tetur03g09010) 47 TuGR171 (tetur03g08950) TuGR178 (tetur03g08790)

100 TuGR51 (tetur11g01980) TuGR50 (tetur04g02760)

100 TuGR35 (tetur14g00710) TuGR34 (tetur01g05060) 40 TuGR47 (tetur10g02840)

100 TuGR44 (tetur13g03090) TuGR45 (tetur13g03110) 100 100 TuGR43 (tetur13g04696) 100 86 TuGR42 (tetur13g03050) TuGR46 (tetur19g03401) TuGR41 (tetur11g06420) TuGR40 (tetur03g09090) 60 100 75 66 TuGR39 (tetur10g05784)

98 TuGR36 (tetur03g09110) 100 TuGR38 (tetur03g09100) 58 TuGR536 (tetur08g08379) TuGR439 (tetur08g01490) 96 TuGR61 (tetur08g01450) 100 92 TuGR62 (tetur08g08309) TuGR59 (tetur08g01440) 99 100 TuGR60 (tetur08g01510) 50 TuGR58 (tetur08g01380) 30 73 TuGR57 (tetur08g08299) 62 100 TuGR56 (tetur08g08329) 89 TuGR55 (tetur08g01400) 93 TuGR54 (tetur08g01420)

100 TuGR442 (tetur08g08319) 93 TuGR52 (tetur08g01370) 89 TuGR53 (tetur08g01390) TuGR48 (tetur26g02843) 54 TuGR49 (tetur11g04930) TuGR211 (tetur27g01230) TuGR576 (tetur17g03880) 100 TuGR32 (tetur17g03870) 95 100 TuGR31 (tetur17g03860) TuGR210 (tetur01g06380) TuGR212 (tetur20g00810)

53 TuGR535 (tetur08g07160) TuGR30 (tetur24g01040) 84 TuGR29 (tetur16g00670)

41 100 TuGR28 (tetur08g00330) 39 TuGR27 (tetur04g08780)

78 TuGR20 (tetur09g06728)

84 100 TuGR18 (tetur09g03430) 100 TuGR19 (tetur09g06789) TuGR10 (tetur19g03411) 100 100 TuGR8 (tetur41g00690) 100 100 TuGR9 (tetur41g00720) TuGR7 (tetur27g01920) 97 TuGR6 (tetur01g01400) TuGR22 (tetur30g02479) TuGR26 (tetur30g02459) 97 100 100 28 TuGR25 (tetur30g02449) 100 TuGR24 (tetur30g02439) 72 TuGR23 (tetur30g02469) 100 49 TuGR21 (tetur30g02429) TuGR17 (tetur17g03040) TuGR12 (tetur29g01290) 91 TuGR16 (tetur07g08057) 100 TuGR14 (tetur07g08067) 10053 100 TuGR15 (tetur07g08077) TuGR13 (tetur01g07520) 43 TuGR11 (tetur01g16714) TuGR33 (tetur06g00770)

99 TuGR214 (tetur10g05170) TuGR213 (tetur03g02210) 99 TuGR215 (tetur22g02600)

0.5

Suppl. Fig. S1. Phylogeny of intact T. urticae GRs from clades A, B, and C.

Maximum likelihood phylogenetic analysis of intact T. urticae GRs. The scale bar represents 0.5 amino-acid substitutions per site. The tree was midpoint rooted and the numbers at the branch point of each node represent the bootstrap values resulting from 1000 bootstrap replicates. TuGR-As, TuGR-Bs, and TuGR-Cs are depicted in blue, orange and green font, respectively (see top). TuGR81

TuGR69 TuGR112

TuGR129 TuGR108

TuGR591 Gr93d-PA TuGR154 TuGR114 Gr47a-PB TuGR580 TuGR122 Gr92a-PA TuGR529

Gr93c-PA TuGR123 TuGR200 Gr59f-PA TuGR178 91 Gr59e-PA Gr36b-PA

Gr93b-PB

Gr93a-PA Gr36c-PAGr36a-PA

Gr85a-PA TuGR188 Gr59c-PA Gr59b-PAGr59a-PA TuGR182 45 Gr77a-PA Gr89a-PA 48 Gr59d-PA Gr10a-PB TuGR47 99 Gr22c-PA 71 0.5 Gr22f-PA 100 Gr22e-PA

85 87 Gr22a-PA 46 99 56 TuGR62 35 45 Gr58c-PA Gr58a-PA

93 Gr10b-PA TuGR528 52 TuGR16 55 Gr58b-PA 29 Gr39b-PA TuGR310TuGR27 96 82 TuGR290TuGR280 35 100 67 Gr97a Gr94a-PA TuGR275 100 Gr23a-PB Gr98d-PAGr98b-PA TuGR262 74 19 61 Gr98c-PA TuGR302 24 69 TuGR294 100 Gr98a-PA TuGR375 41 70 Gr9a-PA Gr47b-PA 50 29 43 87 100 Gr8a-PA TuGR396 100 99 11 12 TuGR386 2 Gr57a-PA 4 62 62 7 59 TuGR368 77 0 1 1 Gr2a-PB 83 32 77 17 Gr32a-PA TuGR364 0 Gr68a-PA TuGR350 51 96 74 47 37 0 Gr39a-PAGr43a-PA 6 5 46 TuGR337 1 48 99 Gr33a-PA TuGR318 85 84 19 Gr28b-PA 51 43 58 99 32 68 Gr28a-PA TuGR243 1 MoccGr63 TuGR229 2 15 Gr66a-PB TuGR253 5 15 93 100 MoccGr62 7 MoccGr64 98 78 15 50 56 TuGR255 MoccGr56 IsGr40 77 40 74 27 MoccGr58 IsGr37 MoccGr53 IsGr33 89 23 MoccGr52 IsGr14 14 93 31 54 MoccGr54 IsGr9 100 MoccGr55 21 IsGr19FJ MoccGr57 100 96 MoccGr61 IsGr21FIX 98 22 MoccGr60 52 IsGr3FIX 73 75 98 IsGr32FIX 66 99 13 MoccGr41 IsGr26 68 25 MoccGr43 100 50 16 25 100 IsGr31FIX 42 74 100 MoccGr44 98 IsGr30FIX 67 97 MoccGr35 IsGr24 100 60 28 14 65 MoccGr38FIX IsGr25 27 IsGr28 100 80 MoccGr36 26 97 87 95 89 11 42 24 11 MoccGr30

IsGr10 100 61 6 MoccGr37 IsGr29FIX 55 97 IsGr27 9 79 100 18 MoccGr39FIX IsGr11FIX 100 93 IsGr15 100 64 15 81 11 100 MoccGr25 IsGr12FIX 100100 99 75 89 88 44 65 17 19

97 72 MoccGr24 IsGr18 93 IsGr13FIX 97 90 100 28 MoccGr28 IsGr2FIX 85 70 IsGr1FIXIsGr16FIX 66 99 78 Gr63a-PB 43 75 IsGr35IsGr34 MoccGr21 Gr64d-PAGr64b-PA Gr64c-PA Gr21a-PA 32 47

95 MoccGr20 100 MoccGr29FIXMoccGr26 Gr64f-PA 100 MoccGr17 Gr64e-PAGr5a-PAGr64a-PA 85 IsGr47 MoccGr18 MoccGr59 MoccGr19 Gr61a-PA 84 100 MoccGr33 MoccGr16 100 MoccGr15

TuGR511 IsGr48 93 96 MoccGr32

TuGR1 IsGr54 100 IsGr49 IsGr61 IsGr55 MoccGr47 MoccGr40 100 MoccGr48 MoccGr45 MoccGr46 MoccGr1 IsGr50 TuGR5 IsGr53 51 MoccGr50 TuGR510 93 TuGR3 MoccGr49MoccGr51

TuGR543 MoccGr3 MoccGr22

IsGr52 IsGr51 MoccGr23

TuGR2

MoccG6

MoccGr9 MoccGr12

MoccGr5 MoccGr7

MoccGr4

MoccGr13

MoccGr14

IsGr56 MoccGr10

T. urticae Other chelicerates Insects

TuGR-A GR M. occidentalis GR D. melanogaster GR

TuGR-B GR I. scapularis GR TuGR-C GR

Suppl. Fig. S2. Phylogeny of intact T. urticae, M. occidentalis, I. scapularis and D. melanogaster GRs.

Maximum-likelihood phylogenetic analysis of 20 representative intact T. urticae GRs from clade A (TuGR-As) and clade B (TuGR-Bs), all intact T. urticae gustatory receptors from clade C (TuGR-Cs), 57 M. occidentalis GRs, 39 I. scapularis GRs, and 58 D. melanogaster GRs as indicated at bottom (sequences included in the tree are as described in the Materials and Meth- ods). The TuGR-As and TuGR-Bs form sister clades while the TuGR-Cs are present in a clade with low support that includes I. scapularis GRs previously reported as part of “Ixodes expansion 2” (Gulia-Nuss et al. 2016). The majority of M. occidentalis GRs (46 of 57) are present in a highly supported clade representing a lineage-specific expansion reported previously (Hoy et al. 2016). The scale bar represents 0.5 amino-acid substitutions per site. The tree was midpoint rooted and the numbers at the branch point of each node represent the bootstrap values resulting from 1000 bootstrap replicates.

Gulia-Nuss M et al. 2016. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat. Commun. 7:10507.

Hoy MA et al. 2016. Genome sequencing of the phytoseiid predatory mite Metaseiulus occidentalis reveals completely atomised Hox genes and super-dynamic intron evolution. Genome Biol. Evol. 8:1762-75. 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 TuGR236/1-378 ------M-----PSINMQ-QCFVRNEQLK------HYPKVSIDSIPSKFQ-LI------IS------STSNIYGKCLSVFI--MF-LLNLVHCHAL-LYI------S--L------DSIFSIE-IGKLVSL-LLR------NWMFIIFYLN------YNQ------NLCKQIDDHWNGLQ------IDYDY-ETRKYFSTQKAIYRW------LTYILYILPYMMR---Y----CYSFY---MDNDDNKSNL----SSAVDFK-QNIILYFLLTICAPITFFVHFCR------SCILSDLAMLAQTAVQFNLVTLKK------LLKE----SRKDEKSLNINAI------KNIRHKYLLSCRLVDKLNEIMSPSSFLLFIYFLANACHLSYSLLYT-EQNQS----DKWYNIILTSSLLITNLVYTHAMIKIHEKSKESLAIVYRLSL---KTNSMRLLNEISLFL---KHKEIGFSFGGIFMLTTSSLSTLYSIFIT------IILALPS------FVS------TuGR235/1-378 ------M-----ASINMQ-QCFVRNEELK------HYPKISIDSIFSRMQ-LI------IS------STSNIYGKCLFVII--ML-ILNLVHCRAL-LFI------S--L------DSIFSIK-LGAFFFV-LIA------NWLPIVFHLR------YNH------KLVKQIEDHWNGLQ------IDYDY-ETRKYFWTRKAIYRW------LVYFSYIFLYIFK---Y----SYSLY---TLSDKDTSKL----SSEVVLK-QNIIFYFLLLICTPITLFIHCCQ------SCIHIDLPILAQTAVQYNLIKLKK------LLKE----SGKDEKSLNINAI------QNIRYRYLLSCRLVDKINEIMSPALFFMFTYFLANACNLSYSLIYY-EQNHL----TKWYNIFMTSFILISLLVYTHANIKIHEKSQESLAIVYKLSL---KTNSMRLLNEISLFL---NHNEIGFTFGGMFMLTTSSLSKLLSILTT------IIVALPT------FAK------TuGR234/1-373 ------M-----PSINMQ-QCFVRNEQLK------NYPKVSIDSIPSKFQ-LI------IS------STSNIYGKCLFVFI--MF-ILNLVNCRAL-LFI------S--L------DSMFSAK-FGALLFV-LIA------NWMPIVFYFR------YNH------KLVEQIEDHWNALQ------IDYDY-ETRKYFWTHTAIYRW------LVYVMYILLFTFH---Y----CYSIY---TLSDKHTSKH----P-----I-GNGLFYFLLLILALIISSVHFCQ------TCIHMDLPMLAQSAVQFNLIALKK------LLNE----ATKDAKSLNITAI------QNIRRQHLLICRLVDKIDEIMGPSLLLMCTHFLANACHLAYALIYN-EQNQL----TKWYNVILTSFILITNMIYIHANVKIHEKSLELVAIVYKLSL---KTDSIRVLNEITLFL---NHNEIGFTFGGMFLLTTSSLSTLFSILIT------IIIALPS------FAR------TuGR233/1-387 ------M-----TSINMQ-QCFVRNEQLK------HYPKVSIDSIQSRYL-LM------IS------STSNIYGKCLFVFI--MF-IINLVHCRAL-LFI------S--L------DSMFSVK-FGTFLFV-LVV------NVNPILFYYR------YNH------KLVKQIENHWNGLQ------IDYDY-ETRKYFWTRKVIYRW------LVYSSYILLYIFK---Y----CYLIY---TLSDQDTSKQ----S-----I-GNVIFPFLLLILALITIFIHFCH------SCIHWDLSLLAQTAVQFNLIKLKK------LLNE----SRKDQKSLNVDAI------QSIRHKYLLICRLVYKIDEIMSPSLFAMFTHFLAYACNLSYSLIYN-EENQL----TKWYNVILTSFILIISLVSTYVNVRIHEKSLESLAIVYKLSL---RTDSIRILNEILLFL---NHNEIGFTFGGMFMLTLSSLSTLFSILTTNLWEEIMLQILVNELSS------LFFIQLI------TuGR230/1-378 ------M-----ASINMQ-QCFVRNEQLK------HYPTITIDSIPSKFQ-LI------IS------STSNMFGKCLFVLI--MF-ILNLVHGRAI-MYS------S--L------DSVFTLK-IKSFLFF-LIG------NWMFITFYFR------YNH------KLIKQIDEHLKGLQ------IDFDY-ETRKYFWTRTTLYRW------FIRAYYIFSFIIR---Y----CYELY---TWSVKDRSKL----SSEVAFK-RSIIFYFLLFICAPVAYFKHFCQ------IYIEVDLPILAQTAVQFNLIKLKK------LLNE----TTKDEKSLNLNAI------KNIRHKYLLSCRLVDQINEVMSPALFFLFTNFIINTCNLSYTLLYT-EQSYM----SKCYNLIQNSFSLVGALLSTYSSIKIHDQSLESLATVYKLSL---KTNSIRTLNEISLFL---NHKEMGFTLGGMFMLTTSSLSTLFSIFIT------IVFALPT------FAS------TuGR232/1-377 ------M-----PYINM--QCFVRNEGLK------HYPKVSIDSIPSKFQ-LL------IS------STSNTFGKCLFVFI--ML-ILNLVHCRAL-LNI------S--L------DSIFSVN-LRALLFP-VLG------NGMFIVFYFR------YNH------KLLEQIDDHWNSLQ------IDFDY-ETRKYFWTHKTTYRR------LTYIVYILAIVLR---Y----CYELY---KWNNADRSNL----PSHIVFK-QSFVFYFLLFICAPIAYFKHFCQ------TCIHVDLPILAQTAVQFNLIKLNK------LLNE----ATKNEKSLNIDDV------QNIRHKYLLTCRLVDKINEIISFCLFFMFINFLVNSCNLCYNLLYT-EQSQL----TKWYNVIQNSFIFTNNLVYTRSTLKIHEKSQESLATVYKLSL---KTNSIRILNEISLFL---NHEEIGFTFGGMFMLTTSSLSTLFSILIT------IIFALPS------FAT------TuGR245/1-378 ------M-----PSINMQ-QCFVRNEQLK------HYPKVSINSIPSRYL-LM------IS------STSNIYGKCLFVLI--VF-ITNLVHCRGL-LYM------S--L------DSVFSVQ-LRTFIYF-LHG------NWIFMVFYLR------YNH------NLLKQIDEHWNGLQ------IDFDY-ETRKYFWTRKAFYRY------LTYVLFTLSIIIT---Y----GSQFY---AWNDKDNSKL----SREVFFK-QNIIFYFLLMICVPIVYFNYIFQ------CFIQMDLPILAQTAVQFNLIRLKR------LLNE----AKKDEKSLNINAI------QNIRQKYLLCCGLVDKIDEVMSPCLFLMFTDFVVHASALSHALLYT-ELNQS----TQWAVVMQNSLNLINAWLFTRSTLQIHEKSLESLAIVYKLSM---KTNSIHLLNEISLFL---NHNEIGFTFGGMFMLTTSSLSTLFSVLIT------FILALPS------FAT------TuGR239/1-372 ------M-----TSINMQ-QCFVRNEELK------HYPKVSIDSIQSKFQ-LM------IS------STSHIYGKCLFVLI--MF-LFNLYYFREL-LYF------S--L------DAIFSFT-FESFIRL-LYG------NGIDMVFYFK------YNH------KLMKTIDDDWNGLQ------IDFDY-ETRKYFWTHKAKCRR------LINVVSIFYLIIT---C----FYPIS---LYNTQQRIKL------V-QHIIYYFCLLVCFPLYQYKRFCH------CCIYVDLILLAQTAVQFNLIKLQK------LLNE----TRKDEKSLNINVI------ENARNKYLLSCRLIDKMNDIMSPCLFFIFTNFAVNAGHLFYNLLYT-KEDEA----GKLITNFQLSCSLTLVLLYTHLSLKIHEKSLESLATVYKLSL---KTNSIRLLNEISLFL---NHNEIGFTFGGMFMLTTSSLSTLFSIIVT------IVFALPT------FAR------TuGR240/1-372 ------M-----PSINMQ-QRFVRNEQLK------HYPKVSIDSIQSKFQ-LM------IS------SNSHIYGKCLFVLI--MF-LFNLYYFREL-LYF------S--L------DAIFSFT-FESFIRL-LYG------NGIDMVFYFR------YNH------KLMKTIDDHWNGLQ------IDFDY-ETRKYFWTHKAKCRR------LINVVSIFYLIIT---C----FYPIS---LYNTQQRIKL------V-QHIIYYFCLLVCFPLYQYKRFCH------CCIYVDLILLAQTAVQFNLIKLQK------LLNE----TRKDEKSLNINVI------ENARNKYLLSCRLIDKMNDIMSPCLFFIFTNFAVNAGHLFYNLLYT-KEDEA----GKLITNFQLSCSLTLVLLYTHLSLKIHEKSLESLATVYKLSL---KTNSIRLLNEISLFL---NHNEIGFTFGGMFMLTTSSLSTLFSIIVT------IVFALPT------FAR------TuGR241/1-364 ------M-----PSINMQ-QCFVRNEELK------HYPKVSIESIPSKFQ-LF------IS------STSNIYGKCLFVLI--ML-VINLFYCREL-L------S--L------DAVFSFK-LSAFIQL-LYG------NCLYMVFYFR------YNR------NLVKQINDHWNSLQ------IDYDY-ETRKYFWTHTAIYRR------LLYVLYTLFFIIS---C----FHPIF---LYNG------Q-HNIVIYFYLLVCSPLSLFNRICW------NCIYFGLIHLAQTAVEFNLVKLKK------MLHE----SRKDEKSLNINAI------KNIRHKYLLSCRLVDKINEIVSPLQFLIFTNLIANACQLSYSLLYN-EQNEL----DKLLGNIQMGSILMHILLYTHLTVKVHKKSQESLAFVYKLSL---KTNSMRLLNEISLFL---NHNEIGFTFGGMFLLTTSSLSTLFSILTT------IIIALPT------FAK------TuGR242/1-376 ------M-----PSINMQ-KCFVRNEQLK------HYPKVSIDSIPSRFK-LM------IS------STSNFYGKCLFVIM--MF-SLDIFAVLDL-LYI------S--F------DSIYSAQ-LQSFHAI-L-G------HLPYLIFYFR------YDH------KLVKQIEEHWNALQ------IDFDY-ETRKYFWTYKAFYRW------LTYFMYIIAIIII---Y----FNQSS---MQMEKDKI-I----SSEVVFR-ENIKFYYACLIIGPLAFLNFFCN------CCIQMDLPILAQTAVQFNLIKLKK------LLNE----SLKAEKSLNIDDI------QNIRHKYLLSCRLVDKINEIMSPCLVLAFTHFVANGCALAYTMLYT-QPNQL----TSWSPVIISSFFFTTSLILTRSALKINEKSLESLAIVYKLSL---KTNSIRILNEISLFL---NHNEIGFTFGGMFMLTTSSLSTLYSAFIT------IVLAIPS------FSR------TuGR238/1-379 ------M-----PSINMQ-QCFARNEKLK------HYPKVSIDSIPSKFQ-LM------IS------STSNIFGKCLFVFI--ML-IMNFVHCRHL-LHI------S--L------DSVFTVK-IRGLTHF-LKD------NWLPIIFYLR------YNH------NLMRQIDDHWNRLQ------IDYDY-ETRKYFWTRKAFNRW------ILNVLVILSFIIS---Y----CYGFY--KMYYYTDGDKL----TSELNFK-QNSISITIVWLFGSILYFVHFCK------LCIYIDLVILAQTAVQFNLIKLKK------LLNE----STKDGKSLNINDI------QNIRHKYLLSCRLVDKIDEIISLDLLFKFTDFVINSFDLSYTLLYT-EQNRW----DKCNKIIHHTIGLIYTVFYTHATLKIHDQSLESLAIVYKLSL---KTNSIRLLNEISLFF---NHNEIGFTFGGMFMLTTSSLSTLFSMLVT------IVFASPS------FVS------TuGR237/1-366 ------M-----TSINMQ-QCFVRNEQLK------HYPKVSIASIPSRLL-LM------IS------STSNIYGKCLFGLI--MF-LPNLYYFYYF-LHT------S--L------DAIFSGK-LKNFLRF-LHG------NWIFIVYYFR------YNH------ELVKQINDHWNALQ------IDFDY-ETRKYFWTRKAIYRR------LTNALYIFLIIFR---Y----GYEFY---IWND------R-HGIMFYFLLLIWTPIGFVKHFCE------SCILLDLLTLAETAVRFNLIQLKK------LLKK----STKDGKSLNTNAI------ENIRHKYLSSCRLVEKIDEIISPHLLLMFVDSLISACDLCYNLLYT-EQSQV----HKCYQIIFNSVILITILVSTVLGIKIHEKSQQSLAIVYKLSL---KTNSMRLLSEILLFL---NQSEIGFTLGGVFMLTTSSLSTLFSILTT------IVFALPT------FAK------TuGR243/1-372 ------M-----PSISMA-QFFARNEELK------HYPKVSIDSIQSRYL-LM------IS------STSNIYGKCFFVLT--II-SSTLLHCRYL-LYN------F--M------DPSLSIQ-FKTFLYV-FLE------IAMFSSFYFN------YNH------NLVKQIEAHWNGLQ------IDFDY-ETRKYFWTHKAIYRR------LTYAM---LFILN---I----SYQFH---LWNDNYMIKY----KGK---L-ASVIFYLVFTICGPIHYFNHFCK------TCINMDLPILAQTAVQFNLIKLKK------LLNE----ATKDEDSLDINDI------QNIRYKYLLSCRLVDKINEVMSPLLLCRFTYFLLNAWSLSYSLLYA-KQDQS----YQWLSVIQSGLILTAILLYTHSSIKIHEKSLESLATVYKLSL---RTDSMTLLNEISLFL---KHEEIGFTFGGIFMLTTSSLSSLFSILIT------VIIALPS------FSR------TuGR642/1-372 ------M-----PSISMQ-QFFVRNEELK------PYPKVSIDSIQSRYL-LM------IS------STSNIYGKCFFVLT--II-SSNLLHCRYL-LYN------F--M------DPSLSIQ-FKTFLYV-FLE------IAMFSSFYFN------YNH------NLLKQIEEHWNGLQ------IDYDY-ETRKYFWTHKAIYRR------LTYAM---LLILN---I----SYQFH---LWNDNYMIKY----KGK---L-ASVIFYLVFIICGPIHYFNHFCK------TCINMDLPILAQTAVQFNLIKLKK------LLDE----SAKDENSLDINDI------QNIRYKYLLSCRLVDKINEIMSPLLLCRFTYFLLNAWSLSYSLLYA-KQGQS----YQWLSVIQSGLILTAILLYTHSSIKIHEKSLELLATVYKLSL---KTNSMALLNEISLFL---KHEEIGFTFGGIFMLTTSSLSTLFSILIT------VMIALPS------FSR------TuGR244/1-373 ------M-----TSINMQ-QCFVRNEQLK------HYPKVSIDSISSRFQ-LI------VS------STSNIYGKCLFVLT--IF-SSTLVHCHDL-LYS------S--M------DLSLSGQLFKTFLYV-LLE------IVMFSAFYFN------YNH------RLLKQINDHWNALQ------IDYDY-ETRKYFWTHKAIYRW------LTYAL---LSIIY---I----SFHFH---LWNDNDMIKY----KSK---F-AFTIFCFEWFICAPMHYFHHFCM------TCINMDLPILAQTAVQFNLIKLKK------LLQK----SAKAKKSLNIKDI------QNIRHKYLLTYYLVDEINQIMSPLLLCRFGFFLLIAYHSSYDLFYA-EQDQS----NKGLLFITSSLVLIAVLLYTHSSIKIHEKSLETLAIVYKLSL---KTDSLRILNEISLFL---NHSEIGFSFGGMFMLTTSSLSTLFSILIT------VIIALPS------FSS------TuGR248/1-380 ------M-----TSINV--QNNIRNEELK------NYPKMSINSIPCRFK-LM------IS------STNGAFGKCLFLLL--LL-FQNSMYFNPL-MKI------S--L------DSVFSIE-PKSIVIF-LIQ------NSGISFFHFN------YNH------NFLRQIDDYWNELQ------IDFDY-ETRKYFWTQMAIGRS------FTIILYIIIFTLN---Y----SYLFY---AWYQEKTY------SSKDFSL-DDVFNYVFHIIFGPVAYYNFYCQ------SCVLIDLLILAQTALQFNAIKLKK------LYKE----SVKDDKILNIDVI------ADLRKKYLSTHRLVDKINEIMSPSLFLIFMLFVSNSCDLFYALIFL-EHHLL----IKLNRTIRCVLGLILLLKIAHLAIQVYAKSQELLMTVYKTSL---KTDSIRILNQITLFL---NCNEIGFSFGGLFMLTTSSLSTLFSILTT------IVIAIPS------FNKHENTH------TuGR246/1-378 ------M-----TSINRH-RCFLKNENLK------NYPKISIDSIPSRFK-LM------IS------STNGALGKCLFILI--AL-VLNMRYLNFI-FAI------S--S------DVGLS---KIAVYYA-VIE------NIYFIFLHFN------YNH------KFLGQINDYWNELH------IDFDY-ETRKYFYTQKTISRL------FTLVTFTSYLAFK---Y----SDSFY---AWYTETTNN-----SSKDSFL-DDVLYYVMHFIVGPVSFANNFCQ------SCIFTDILILAQTALLFSVIKLKK------L--G----SVRGKKILNIDVI------TDLRQKYLSTHRLVEKINEIMSPCLLIMFIHFTLWVIHLSYVLLFL-DAHQL----IKFNRIMQCVIVLISLVFIASLAIRVHKKSQELLMTAYKLSL---KTDSIIILKEITLFL---NCNEIGFSFGGLFMLTTSSLSTLFGILTT------MIIAIPS------FNKHEDTH------TuGR247/1-383 ------M-----TSINRH-QCFLKNEDLK------NYPKISINSIPSRYK-LM------IS------STNGALGKCLFILI--AL-VLNMKYLNFI-LAI------S--S------DPGLSVLSKSAVCYA-LID------NIYFIFLHFN------YNH------EFFGQIEDYWNELQ------INFDY-ETRKYFWTQQAISRL------FTLVTYTSYIAFN---Y----IDSFY---GWYTETANN-----SSKDSFI-EDVFHYVLQIIVGPVSYFNKFCQ------TCIFNDILILAQTALLFSVIKLKK------LYIG----SVRGKKILNIDVI------TDLRHKYLSTHRLVEKINEIMSPCLLIMFIHFTLWVIHLSYALLFL-DVHQL----IKFKRIIQCVIMLMILVFMASLAIRVHIKSQELLMTVYKLSL---KTDSIRILSEMTLFL---NYNEIGLSFGGLFMLTTSSLSTLFSILTT------IVIAIPS------FNKHEDTD------TuGR249/1-373 ------M-----TSINV--QCNIQNGKLK------NYPKVTVNSIVSKYK-LV------IS------STGNKIAKCLFILF--ML-QGYILFLNEL-WES------N--L------NSHPLSR-LGIIVED-SIQ------YVVAIFMYLN------YNH------NFLRQIEHHWNELQ------INFDY-ETRKYFWTQMVIGRL------FSIFTVIQITIYY---I----SCVFY---LLEHSLLHDV------SSIE-DNVIFHLVWIIFFPVVYFNTFCD------FFIHIELSILAQSALQFNLIKLNK------LYKE----SVKDNKILNIDVI------QDLRQKYLSTRRLVDKINETMSLYSCSIFILFVINSCHLFYNLLYL-ESHR-----TKWTQASMSVLFLISFSKLAHSAIQVHTTSQEILMTVYKLSL---KTDSIRVLNEITLFL---NCNEIGFSFGGLFMFTTSSLSTLYSILMT------IVIAIPS------FAS------TuGR222/1-370 ------M-----ILIKVL-KYWTRGDEPP------NFPAITINSISSNLM-LN------VS------SSSGIVEKCLFAFT--MI-LLNLKNIVSL-HSI------S--L------ETVFNAN-VHTILYF-LGR------VCIFSLFYLK------YTR------TFVKKVEELQNELK------IEFDY-ETRKYFWTRKVIYYS------FNVGSKICLLINT---M----GNAYH---KWPYSDLER------RDEVDYWIMVIRVLIIYPFFTCQ------DCILYDLAITARAAIEYFETQSKR------IYKE----SLKDEKALNFQAI------HDLRLKYLQTHRLVNKINEFMSPCLLVSLIIYVNHFINAVYQTLFV-QQSRS----EQMYRLSSSVGAFTLTITFVHLAAQVYQQSQQLLMTVYRLSL---KTDHLKVLNEISLFV---NCNEIGFSLGGICMITSSTITTTLSILVT------LIIAIPS------FAN------TuGR223/1-372 ------MM-----ILIKVL-QCWIRNDEPV------NFPEITINSIPSKLM-LH------VS------STSGTGQKCLFAFI--MS-LHNLRYVIKL-WGI------S--L------DAVFEAN-VNIILYF-LGQ------ICIFSLFHLK------YNN------TFVEKVEDLWNDFQ------IEFDN-ETRKYFWTRKVFYYS------ATVFSKICYLIYD---M----SKTYH---NWPYSDSEK------L-RNEVDYWFGVIRLAIIYPFFICQ------DCILFDLSITAETAIEYIESQSKR------IYKE----SLKDEKALHFKVI------HDLRLKYLQTHRLANKMNEFISPCLPVFLLIYMQHFIYLVYLILFV-QQSQF----LLISRIIACIGAFPVTIVYIYSTAQVYKKSQQLLMTVYKLSL---KTDYLKALNEITLFV---NCNEIGFSLGGICMITSSAITTTFSFIAT------LIIAIPS------FAR------TuGR226/1-370 ------M-----ILMKVL-QYWIRSDEPT------NFPAITVDSIASRLI-LK------VS------STSRTMEKCFFAFT--MI-LLYFRYLIKL-CGI------S--L------DAVFTVD-ANTILYF-LCQ------ISLFSLFYQK------YNH------TFVEKVHDLWNELQ------IELDY-ETRKYFWTHKVFYYS------VTVFSKICTLIYD---L----GNVYY---YWPYKDSDS------L-QSPFDYWTWVMRVPIIYSYYICH------DFILCDLSIAAQTAIQNIESQLKR------LYKE----SLKDERALHFTII------HDLRIKYLQTHRLVNKMNELMSPCLLVFLIIFTNYFIRMFYLILFV-QQSRF----VQMYQLSGCIGSFILIITIIHLTAQVYLKSQRLLMAAYKLSL---KTDYLKVLNEITLFV---NCNEIAFSLGGICMITSSAITTFFSILAT------LIIAIPS------FG------TuGR225/1-370 ------MM-----ILIKVL-QHWIRSDEV------NFPEITINSIASKLI-LK------VS------STSGIVGKCLFAFA--IS-LIHSRYLIKL-PGI------S--F------DKVFTAD-PNTILDF-SCG------IFYFSLFHFK------YNH------IFVKQIEDVWNELQ------IGFDY-EARKYFWTRKVIYYS------VTVGT-ICLFIHD---I----SYFYH---NWPYSDPKR------L-QNQFDYWTSVMRLPIIYPYVVCN------NCILYDLSITAETAIQYIDTQSKR------LYKE----SLKDEKALNFQVI------HDLRLKYLQTHRLVNKMNEFLSPYLLLSLIICIHHFIYLVYSILFV-QQSGL----SRICQVISFVGFSTFTFFITHLSSQVHVKSQQLLMTVYKLSL---KTDFLKVLNEITLFV---NCTEIGFSLGGICTLTSSAITTLFSILTT------LIIAIPS------FIK------TuGR224/1-371 ------M-----ILIKVL-QYWTKSEEPV------NFPEITINSIASKII-LY------VS------STSGKLGKCLFAFT--MS-LLSFRYLIRI-SYL------S--L------DSVFKAD-FFAILFI-FCK------VCIFSLFYLK------YNH------NFAKKVQDLWYDLR------IEHDY-ETRKYFWTRKVIYYS------LQATCYAGYIIHD---A----CLFYH---IRPDADSER------L-QNVLYYWETVLEMPILYYYVICH------HFILLDLSVLAQTAIQYLETQSER------IYKE----SLKGRKVSNFKAI------HDLRLKYLQTHLLVNKMNKLMSPGLFVYLVLPLDQFIKQVYSVLFV-QQSQL----LRIHRVIGCIAALILAISIIHSTAQVYLKSQALLMTVYKLSM---KTDYSKVLNEITLFV---NCDEIGFYFGGICTITYSTITTTFSLLAT------LIISMPS------FAG------TuGR227/1-339 ------M-LN------VS------STSGIVQKCFFAFT--LI-LLQLKFLIGN-RDI------S--L------NSIFTAD-SRLIVFF-LCD------ICIFSLFHLK------YNH------TFVKKVNDLWYDLR------IEHDY-ETRKYFWTHKVTYRL------LQVTCLIFYLTFN---I----FHFY----KWFNSGLEK------L-GNADLFWASITRALIFYPYLISH------NFILFDLSILAETAMQNIEKHSKE------LYKE----LLSNEKVLNFEAI------HNLRLKYVQIHQLVDKINEIISPCLLVYLINFICRFIHLVYLILFV-QQSGL----SRLYQIIGGIATFTITYFIIHLTLQVYLKSQQVILTVYKLSL---KTDYLKVLNEITLFV---NRNEIGFSLGGICMITSSTMTTLFSVLGT------LIIAIPS------FAR------TuGR228/1-390 ------M-----VFIKVL-KDWILNNEPT------DYPKISIYSTSSKLA-LS------VS------STASVWGKCFCMLM--FI-LLNLKYLFRL-LDI------S--L------DSVSDLN-FYLIIGA-SFE------NCLHIFFYSK------YNH------TFLKQIEKHWNELQ------IDLDN-ETRKYFWTRKVIYYL------LYTSSIVFSFIYD---I----ENNIR---TWPYSDADQS----THKSIYM-KNSIHYWTKFIRFLTVYPYIFLE------AFILFDLLVLSQTALKYIDLQLNR------LYKA----SKTNER-LNINVV------HDLRLKYFLTHRLVNKMNEYVSPCLLFHCIIFLNLFVYILYFGLFV-QQSLV----RRLYLTIGYFAMIMNLFLIIYATVNVYTKSQDVLAMVYKLSF---KADYSAIKNEISLFL---NYDGIGFSLGGIIMITTASISTLFSFLLT------IIIAIPS------FDGSNHSSVNITSNKN----- TuGR229/1-378 ------M-----AFVKVL-NGWMRNNELT------DYPQIPIYSTASKLG-SS------IS------SKSEFRGKCVAILV--II-LLNFKYLFRS-LDV------S--L------DSGFDVE-FKIFIDC-LCE------LGMHFLLYFK------FNL------NFLRQIENLWKELQ------IDSDY-AAKKYFWNHKVIYYI------LSANFSVSLLIYD---I----ANMFR---IWPYSDAGQS----TTISIYR-KNPIHYWTIIVRIIIIHPYNLLQ------TFILFDLLVLAQTALQHVNMESHR------LYRA----SNIDIKTLNIKAM------RNLRLKFFSTQRLVNKMNEFFSPFLFPYCVIFMNRFINLLYFGLFV-QQSLG----TKIYRTVGCVGMLSLLILVVHAAVKVYTKSQEVMVTVYKLSL---KTDYLRVMNEISLFL---NCGGIGFSFGGIFMINTSTVFTFFSILAT------IIVSIPS------FTR------TuGR219/1-387 ------M-----SDIAIL-KSLLSKNEM------IYPPISIDSFSSKWN-LM------TS------STNGIIGNLLFLLT--AG-LMVARYLIKL-PTI------S--L------ESTFTIN-PAEAMYS-AIK------VFVLTLFHFK------YNQ------RFFDEIITRFKAIN------IDFDD-QTRKYFWTRRAAYRI------LMLLGYMPRVYYC---I----VIYKY---SWPHQSSDQTPKLYSISARLN-DDPLNYWTSLFASLLSIPLSLFH------DLAFIDLAMLVQSALYYINNQVTA------ISKE----MNIDGSKLDCKAV------KTLRWQYLLVHRLVDKSSSLTNLCTFGLISYYMTFFIFCFYTLAFD-DHILP----IKISTILQTSGILIVLCLIIHAVVTIYTKSQESLPTLYKLSF---ETESFQILNEISLFLYRIGFNDVGFSFGGIFMITPDFISTLAAVTIT------VIIAIPS------FVVPSS------TuGR217/1-378 ------MM-----TDIKIL-KSLLSKNEV------NYPKVSIDSLSSRLN-LI------VS------SSNGVTGNGLFLVI--LS-LIFSRHLTIL-IKI------S--L------DSTFSFN-PLEVLHF-SFQ------LFNFSLFHFK------YNQ------QFLDKVIAKYQVIN------IDYDH-QTRKFFWTHRIIYRI------LLILSYMPQALHD---M----HVFKH---SWPHQS------ATSASTP-NDALDYWLSILSTAIYYPFALSQ------DIILIDLAMLSQVTLHNINDKLNA------VSGE----LQVEGNKLNNKVI------KMLRWQYLLIHRLVDESSSFMNLATFGLISHYVYFVIVDFYTLAFD-KQIVP----IKISSMFASMGILLELCLITHSVVAIYIKSQQPLPILYKLSF---KTYSFHVLNEISLFLYRIGFNDIGFSFGGLFMITPDFTSTLALVTIS------IIIAIPS------FHSA------TuGR218/1-377 ------M-----IDIKIL-KRLLSKNEA------NYPKISLDSLSSRLN-LI------VS------SSNGVTGNVLFLVT--MV-LIFARHSTKL-VNF------S--L------DSTFSFS-PLEVTHF-SFQ------LFIFFLFYVK------YNQ------QFLDKVIAHYHVID------IDYDH-QTRKFFWIHRTVYRI------LIILSYIPQALHK---V----NVYKH---SWPYQS------QTSVSTS-SDFLNYWLTILSTTVYYPFALSQ------DLILIDLAMLSQATLSNINDQLNA------VSKE----MQLEGNKLNNKVV------KMLRWQYLLIHRLVDESSLFMNLAAIGLISHYVFIVIVDVYILVFD-KQIVL----IKISSMFAFLGILVELCLITHSVVAIYIKSQQPVPILYKLSF---KTDSFSVLNEISLSLYRIGFNDIGFSFGGLFMITPDFISTLAIVTIS------IIIAIPS------FHSA------TuGR220/1-383 ------M-----YILDKL-FNWMSNKNIK------NYPKVSMNSFSSRFN-LI------VS------STKGLLGNGLFILL--FV-STQLKFWVKL-GYI------S--L------DSTFSVH-PETIIYC-FIE------IYLLSLFHFK------FNE------KFLTQVHQIWKSLN------IDSDD-STRRYFWTKESSYRK------MITISYFSMGVSV---L----LVHAA---SWPYTSVSPSE--YSIEMLLS-EPSVKFWSEMLADIVLYPVCLMQ------DFIIIDSAFLAQSALHYINNRLAI------IDKQ----LKMNDMKLDIKAI------QDLRVKYVLTHRLVKRLGSFVNPCLFGIFSYYVSILNVKIYKILFT-EHNQF----YLTVALIDFFGTITELFLLIIPIATITTKSREFHKTLYKLTF---NTDSFHYLNEISLFLYRMSFNNIGFSFGGIFMITPDFTSSLIAVTFT------IIIAIPS------FIS------TuGR221/1-383 ------M-----YVLNKL-FNRMSNKPKK------MYPKVSMNSLSSKVN-LI------VS------STNGLLGNGLFVLL--LL-STQFRFLVKL-SET------S--L------DSTFSVS-PETIIYC-LIE------IYLICLFHFK------FDK------KFIHQVHQIWQLLM------IDFDH-STRCYFAIQRSSYRK------MIIITYFFMWIPD---L----VLDAA---PWPYTWVSSFE--CMIEMLLS-EPSLHFWSRVFVLVILYPACLMQ------DFIIIDSAFSSQSALHYINNQLAI------IDKH----LKMNDVKLDIQVI------QDLRVKYVLTHRLVKKLGSFLNPCLFGIFSYYVSILNVKIYNILFI-EHEQS----DLILLLIDCFGTIAELFLLIIPIAAITTKSREFYTTLYKLTF---RTDSFKDLNEISLFLYRMSLNNIGFTFGGIFMITRDFISSLIAVTVT------IIIAIPF------FIS------TuGR309/1-403 ------M-----DLIEAF-QSF------DELSAPPSRLFLPAISKFKNKINS------NQIDSQLDYPYFGINSI------TDQPILSFY------LKQPKIGFILSAFLT----LNLLDLVYNF-ITDP-SII------TGEL------IVYLIKL-VNG------L--YSLVLVYLFL------VRP------THVNELITIWKSLS------FGKYK-QCYEYFNHNRKKFHI------VIYIVYVIIGIHEL--I------QLFYSKQSLF----GYIFNFQ-TDPIKT----ILAGMVSYGGIMFAEIILLSQDLVLVDTCFLVYSALRFIRTNLGQ------FNN------NTINRSIL------RYYREKYTLTCDLIISANNYSKLYIFAIYSSYTIILITRVYFTYFI-PRTIK----YVFIASFFHLNHLIDISVVTYLLTKTHSLAQRVQEDLYPLTF---KTDKISSLYEVMLFMYRVGRQDVGFTFGNLFVMTPNFISSLVTISAT------LIIAIPS------FVPYSKKS------TuGR257/1-376 ------MRDAFDDQTLKVT------VEM-----T------F------PTALNEPDQVILDGY-IVPSK------YLLR------QITKILLLLTI--AY-SSAFRIAYMY-IY----LL---RNCKLTT------K--L------MIIDC--AHATIVA-INV------LLTVLMLLFA------FDW------NHFRKFISHIKSLS------LETDR-LTVRTIKQNRRITQA------LLIVTFIIYMIIF---Y----TQQKAI----SIDTV------NPF-VFNLLC----FHEMLIRFVFLFF------LNMICNICFWLKAAFNHINSQISD------LHD-----TSDQSFGHLFCKI------RDLRQKYSYAVRSTQSAEKLFRWFITLYYIEYFTYNIVNIVMSLGP-KMNID------SIWLLFISIATLYFIILTYYLVSVNNLSREGLEDLYELSF---KLNTAQSCHENDIFIARMALSDVGFTFANLFTINNNFITSVFTLSFT------IIITLAS------FIYQ------TuGR258/1-367 ------MEVR------VEM-----P------S------STTSNEPNQVVLDGY-IVPSK------YLLR------KATKIILSLAI--VC-GSAFRLVYMY-IY----FF---RNCKSPT------K--L------KIIGC--VHDMAVA-IDL------VGTILVVIFG------FKW------DNFREFISTIQLLS------LETEE-LAVRTIKKNRRIVQV------LLSVAFIVFMICF---F----VNEKTK----SIGIV------NPF-VFNLLV----LHTAIIRFFVLFL------INMICNICFRLKASFDDINSQICD------LKN-----TSDQSFGYLFHKI------RDLRQKYSYAVRSTQSAEKFLRSIITLYYIKYFNYNTMNIVMSFGP-KTHIS------AIWLLFISITTLHFIILTYNLVEVSNVSRKGMEDLYELSF---KLNTFESCHENDIFIARMALSDVGFTFANLFTINNSFITSLLTLSFT------IIITLAG------FIYQ------TuGR259/1-361 ------M-----F------Q------PKPLNIFNQVILDGY-ILPSK------YILG------PAIKIVLLLTS--AY-GSAFQLSWMS-FY----LF---SNCRYTS------K--I------LLLEF--SFHTTDV-INL------LFTCLVIVFG------FNM------DHFREFISTIQLLH------IETDS-FAVRKIKRNRRIIQA------LLSVAFTIYMTLY---I----ITAKGL----SIHTD------NPF-VFILRC----FHAGLFRFGSLFH------LNMICNICFCLKAAFNQINSQIAN------LNK-----LSDQSFGHLFHKI------RDLRQKYSYAVRSTQSAEQLFRYYITRFYMEYFAFVTMNIVMSFGR-KTRFD------SSWFLYMLIDAILFILLTYNLVSVNNLSRKGMEDLYELSF---KLNTFESCHENDIFIARMALSDVGFTFANLFTINNSFITSLFTLSLT------IIITLAS------FIYQ------TuGR260/1-360 ------M-----F------Q------PKPLNTLNQVILDGY-ILPSK------YILG------PAIKIVLLLTS--AY-GSVFQLSWIS-IH----LF---RTCRYTT------K--I------LLFQC--LHNSLDV-IIL------LCTCLMVLFG------FNM------NHFRKFISTIQ-LA------LETDR-YAVRGIKKNRRIIRV------LLTVAFIIFAIMY---I----ITVRAL----SIHTD------NIF-VFILRF----FHAALFRFGSLFH------LNMICNMCFFLKAAFNQINSQIND------LNT-----TTHRSLDHLFYKI------RDLRQKYSYAVRSTQSAEQLFRWYITRFYMEYFSYITMNIVMSFGP-KTSIN------FVWLIFMLIDTILFILLTYNLVSVNNLSREGLEDLYELSF---KLNKFESCHENDIFIARMALSDVGFTFANLFSINNSFITSLFTLSLT------IIITLAS------FIYQ------TuGR261/1-361 ------M-----S------K------TESLNTANEVISDGY-LVPSK------YILG------PAIKIVLLLSV--AY-ASTFQLSYHS-IS----LV---HTCRYST------K--I------LIFQC--LHEGLAV-VNL------LLFVLVVLFA------FNM------DHFRKFISTFQLLL------LETDT-LAVREIKRSRQIMRA------LVYGIVILFVVMF---I----RRETGS----TNHTD------STF-VFIVRC----FHEVLVRFGSLFH------LNMICNICFCLKAAFKQINLQIND------LNT-----TTHRSVDHLFYKI------RESRQKYSYAVRSTQSAEKLFRYYITIFYTEYFSYFTMNIVTLFGP-KAGLD------SIWFLYMFLDTFLFILLTHNLVEVNNLSREGLEDLYELSF---KLNTGDSRHENDIFIARMALSDVGFTFANLFTINNSFITSLFTLSLT------LIITLAS------FIYQ------TuGR262/1-376 ------MKRIISVQTLKVS------DKM-----S------N------PKSLNEPNQVILDGY-ILPSK------YILG------PATKIVLLLTV--AY-VSAYYVSYLT-LS----LF---RTCKYTT------K--M------VIFMC--AHDAVDA-FTV------LCAGLVIIFG------TNM------EHFRKFISTIQLLS------LETDR-SAVRTIKQNRIIIHV------LLLVILIFFMGTF---F----VKEMSS----SIDTV------KSF-VFIIDC----IHRLLYRSGILFT------LNMICNICCCLKAAFNQINTQITT------LNT-----TSDHSNDHLFDRI------KDLRQKYSYAVRSTQSAEKLFRCYITIFYMQYFSYVTMNSVMSFGP-ETSID------PFWLLYILLDTMHFIILTHHLVSVSNLSREGLEDLYELSF---KLNTAESRHENDIFIARMALSDVGFTFANLFTINNNFITSLFTLSLT------IIITLAS------FLYQ------TuGR669/1-359 ------M-----S------S------PTRPSPPKRIILEGY-ILPSK------YILG------PAIKILLLFTT--AF-CPACRIVYAS-IY----TL---PLCNYNS------K--I------SIFDC--VHSSLEV-IIL------SLVILMVLFG------FNL------DYFKKFISTIELLS------IEFNS-STVGTIKRNRRRNTI------ILLIPFISNVIVC---M----VYTES-----EIQNA------GIF-KVFLIV----INQVCIIFGLFFF------LNMTCNICICLQATFNEINSQIAA------LNQ-----TDNQLF-YSFHEI------RTLRKKYSYAVRSTKNAEKLFRYFITIFYVEYFSLNIMNIVRSFEP-ETKIG------PIWLASILIQTAQLLILTYNLVSVNNISRQGLEDLYEFSF---KLDTIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYH------TuGR271/1-359 ------M-----S------L------LTSPNPPKQMLLDGL-ILPSK------YILG------PAIKILLLFTT--AF-CPTCRIVYAS-IY----TL---PLCNYNS------K--I------SIFDC--VHASLEV-IIL------SLVILMVLFG------FNL------DYFKKFISTMELLS------IEFNS-TTVASIKRNRRRNTI------ILFIPFISNVIVC---M----VYMES-----EIQNV------DIF-KVILIV----INQVCLISGLFFF------LNMTCNICICLHATFNEINAQIAA------LNE-----TDNQLF-YSFHEI------RTLRKKYSYAVRSTQNAEKLFRYFITIFYVEYFSLNIMNIVRSFEP-ETKIG------PIWLASILIQTAQLLILTYNLVSVNNISRHGLEDLYEFSF---KLDTIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYH------TuGR270/1-348 ------MILDGL-ILPSK------YILG------PATKILLLFTA--AF-CPAFRIVYAV-IY----SF---PLCNYTT------K--I------SIFEC--VYTALEV-IAL------SLAIVMVMFG------FNL------DYFKNFISTIELLS------IESEG-STVQTMKRNRRRNTI------ILLLAFIGTIIVC---T----TYMEQ-----EIRNL------GHL-KVILLA----INEVCIAFGLFFL------LNMTCNICICLQVAFNQINSQIAV------LNE-----TSNQMFNHSFHEI------RNLRQKYSYAVRSTQNAEKLLRYFITLFYIEYFSFNIMNIVRSFEP-KTHID------PIWLFVMLCQTIQLVILTYNLVSVNNLSRQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------LIIALAS------FIYN------TuGR272/1-380 MNSLSIAKINFFVETLKFA------VEM-----F------L------PSSENPLKNTILDGF-MLPSK------YMLG------SSIKILLLFTT--AF-CPAFRLVFYA-IY----YL---PNCDYTT------K--E------STFDC--IHTVLDV-IIL------SLEIMLVLFG------LNF------DYFRKFISSIESLS------VENDS-LAIRTIKRNRRLSSL------ILAISFIGNNILC---S----IYTFA-----TNTNI------GIF-EPALLI----TNEVCITFGFFFL------LNMTCNICVFLQAAFNQINSQIAA------LNG-----TTKQMF-NSFDEI------RDLRQKYSYAVRSAQNADKLLRYFVTIFYIEYFSFNIMNIVRFFGP-TTKME------PFWLYAMLFQTVQLIILTYNLVSVNNLSRQGLEDLYEFSF---KLNSLHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYR------TuGR266/1-338 ------MILEGF-IIPSK------YILG------RAIKILLLVTL--AF-CPAIQIAHHS-FY----TL---PLCNYTT------K--I------SIFEC--FHTAVAL-IIM------SLRVLLVLFG------FNW------DYFKKFISTIELLS------IENDN-SAVETIKRKRRLNFT------ILVIPFIGNITLC---A----VFMLS-----FHRNF------GIY-GATLIV----VNEFFIMSGFLFL------LNAICNICIYLQAAFNQINSQIAA------LNN-----ASNQLF-HSFHEI------RNLRKRYSYAVRSTKHAEKLLRYFITLFYIEYFSYGIIHIVKSFGP-KTKVE------PLWLLVIMSQTIQLLILTYNLVSVNNLSRQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMLTLIIW------SQ------TuGR273/1-354 ------M-----S------F------PTSPNFPKQMILDGF-ILPSK------YILG------SVTKIFLLFTF--AC-FSALKIVVYS-IY----AL---PFCNYTT------R--V------SIFEC--VHVSIAV-IIS------SLKVLLILFG------FDL------NYFKKFIATIESLS------ISPDH----RTIKRNRRLSLI------ILVITFTGYSTLC---I----IYRLS-----SIQNL------F-EATLLI----LCDIFIEFGLLFL------LNMICNICICLKAAFNEINSQIAD------LNE-----TPKQVF-NSFHEI------RNLRKRYSYAVRATKHADKLYRYFITIFFVEYFSYNIMNIVRSFGP-KTHID------PFWLFVMLCQTIHLLILTYNLVSVNNLSRQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALTS------LIYQ------TuGR274/1-357 ------M-----S------L------PTSPNPSKEILLDGF-MLPSK------YILG------SVTKIFLLFTF--AC-FSAFKMVYYS-IC----DL---PLCNYTT------K--I------SVFKC--LHVTLAI-IIS------SLKVLMILFG------FDL------NYFKRFISTMELLS------IAPER-SALRTIKRNRQLNLI------ILSMTFIGYSTLR---I----RYRLA-----SIQNL------F-EATLLI----LCDIFIEFGLAFL------LNMICNICICLKAAFKEINSKIAD------LNE-----TPKQVF-NSFDEI------RNLRKRYSYAVRATKHADKLFRYFIAIFYIEYFAYNNLNIVRSFGL-KTQID------SLWLFVMLSLTIHLLILTYNLVSVNNLSRQGLEDLYELSF---KLNSLHLYHENEIFMARMALSDVGFTFANLFTINNSFITSMFSLSLT------IIIALTS------LIYR------TuGR275/1-355 ------M-----S------L------PTSPNLPKEMLLNGF-ILPAK------YVLG------PATKILLLFTF--AF-ISAFKMVYYS-IY----TI---PFCDFTT------K--L------SIFGC--VYASMAV-IFS------SLRVLLILFG------FDL------NYFKRFISTIE--S------IAPDC-SAIRTIKRNRRLNLI------ILVITFIGHCTLC---I----IYRLS-----NIQNL------F-KAALMI----TGDVFFEFGLLFL------LNMICNICVCLKAAFNQINSLIAN------LNQ-----ASEQVF-NSFDEI------RNLRKKYSYAVRATKHAEKLFRFFITIFYIEYFSYNIANIVRACGP-RTHID------AIWLFVMLCRTTHLLILTYNLVSMNNLSRQGLEDLYEFSF---KLNSIHLYHENDIFIARMALSDVGFTFADLFTINNSFIISMFSLSLT------LIIALTS------FIYQ------TuGR670/1-359 ------M-----S------S------PTRPNPPNRIILEGY-ILPSK------YILG------PVTKILLLFTI--AF-CPAFKIAYYS-IY----TF---HFCNYST------K--V------LIFEC--VHIYITV-ITL------SLKVFLVLFG------FDL------DYFKKFISTIELLS------IEANS-TSVRTIKRNRLFNLI------ILVISFISYAIII---A----IYFLP-----HVQKL------GKV-KVTLLI----IDEFLMVIGSLFL------YNMICNICICLRTGFNEINSQIAA------LNE-----KSKHLF-KPFNEI------RSLRKRYSHEVRSTQSAEKLFRCFITLFYFEYFSQNIVNIVRLFGP-QTKIE------LVFILAILIRTVHLLIMTYNLVSVNNLSRQGLEDLYDFSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYH------TuGR263/1-359 ------M-----S------S------PTRTNPPKRIMLDGY-ILTSK------YILG------PVTKIILLFTI--AF-CAAFKIVLYF-IY----SF---EFCNYST------K--V------LIFEC--VHVSIVI-IIL------SLKVLMVVFG------FNL------DYFKKFISIIELLS------IETNS-TTVRTIKRNRQLNLN------ILVVSFMCSAILF---T----VYILP-----HIQKI------GKI-RATLLI----IDEYFMVIGSLFL------LNMICNICICLRAVFNEINSQITT------MSE-----TSNQLF-TSFREI------RDLRKKYSHAVRSTQNAEKLFRCFITLFYVEYFSQNIVNIVRLFGP-QAKIE------TLYLLAISIQTIQLILLTYNLVSVNNLSRQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------LIIALAS------FIYQ------TuGR673/1-359 ------M-----S------S------PTRPNPLKRVILEGY-ILPYK------YIIG------PVTKILLLFTL--VI-CPAFQIAFYS-IH----AF---QVVNYTT------K--V------SMFET--VHLFIVI-IIL------SLKVFMVLFG------FNT------DYFTKFISTIELLS------NEFNS-TTVGTIKRNRRLNLN------IFVPTFICYGILS---M----IYILP-----HMQKL------GIS-KVTFLI----IDESLIVLGSLFL------HNMVCNICICLRAAFSEINAQIAS------LKE-----ASNELS-NLFHGI------RNLRKRYSHAVRSTQNAEKLFRCFITLFYVEYFSQNIVNIVRLFGP-QTKIE------PIFLLAILIRTVHLLILTYNLVSVNNLSRQGMEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYN------TuGR264/1-356 ------M-----F------S------PTRPIRPKRIFLDGY-ILPSK------YILG------PVTKIILLFTF--AF-CPAFKIVFYS-IN----AF---KICNYTT------K--V------SIFEC--VHLSLVI-IIL------SLKVLLVLFG------FDL------DYFEKFTSTIELVS------IDTNN-N---TIKRNRRLNLN------IIAICFISYAILS---W----IYTLP-----YRKKL------GII-NVTLLI----FAESSILLGSLFL------HNMICNICVCLRAAFNEINAQIAA------LNE-----TSNQLF-NSFLEI------RNLRKKYSHAVRSTQNAEKLFRYFITLFYIEYFSNNIMNIVRLFGP-QAKIE------PLYLLAISVQTIRLLVLTYNLVSVNNSSHQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMFTLSLT------IIIALAS------FIYN------TuGR265/1-359 ------M-----S------S------PTRSDPPKQIILEGY-ILPSK------YILG------PVTKIFLLFTI--AF-CPAFKIAVYS-ID----VF---QNYGYTT------K--I------SIFEW--VDPCIFL-IIL------SLKVFVVLFG------FNP------DYFKKFISTVEPLS------IEFNS-ATVGKIKRNRRLNLN------ILAASFICYSILS---M----VYVSP-----YMKIL------GTT-RVTLLI----IDEIFIVFGSLFL------YNMVCNICICLHAAFNEINAQIAA------LNE-----TSNQLF-NSFREI------RSLRKKYSHAVRSTKYAEKLVRCFITLFYIEYFSYNIMNIVKLFGP-QAKIE------PIYLSSICMQTIHLMLLTYNLVSVNNLSRQGLEDLYELSF---KLNSIHLYHENDIFIARMALSDVGFTFANLFTINNSFITSMSTLSLT------LIIALAS------FIYH------TuGR268/1-345 ------M-----D------S------ISPLK------YILG------TPTKILLLFTL--VF-CPAFRIAYQS-IY----GI---SLCNYTT------K--E------STFDC--VHHTVNV-IIL------LLKVLLISFG------FSL------DYFKKFISTIALLS------IDTDS-SAVRSIKRNVQLNLI------ILVIPFIGYTILT---I----FYMLS-----YTQNI------AKS-IVILLI----ISELFIEFGVLFL------LIMICNTCIYLRAAFNKVNSQIAT------LNE-----TSNQLFTRSFHEI------RNLRKRYSYAVRSTQNAEKFFRFFITLFYIKYFFYCIINIVKSFAP-QTKID------LIFFVAILIQTIQLLILTYNLVSVNNLSRQGMEDLYELSF---KLDSIHLYHENDIFMARMALSDVGFTFANLFTINNSFITSLFTLSLT------IILALAS------FIYH------TuGR269/1-360 ------M-----F------S------PTSSSPPKQMIFDGF-ILPAK------YILG------RATKFFLLFSL--AF-CPAFRIAYQS-IY----GI---SHCNYTT------K--L------SIFEC--VYTTVSV-IVL------SAKILLALFS------FNL------DYYKKYVSNIELLS------IETNT-SAARAIKRNLGLNLI------IHVIPFIGYIILS---L----FYMFS-----YYQDI------PRS-VIILLI----ISEFFIEFGVLFL------LNMICNTCIYLRAAFNQVNSQIAT------LNG-----TSNQSFNHLFDEI------RNLRKSYSYAVRSTRNAEKFFRFFITLFYIKYFSYNIINIVQSFGP-QTKID------LIFLVPILIQTVQLIILTYNLVSVNNLSRQGLEDLYEFSF---KLNSLHLYHENDIFMARMALSDVGFTFANLFTINNSFITSLFTLSLT------IILALAS------FIYH------TuGR267/1-358 ------M-----F------STSPISFKQVILDGY-ILPSQ------SILG------TAPKMLLLFTT--AF-CPAFKLAYYS-IY----VI---PFCDYST------K--V------STFEC--IYIDLVV-TML------SLEVLMVLFG------FDL------DYFKKLISTITLLS------IEIDS-SAVRTIKRNRLSNRI------MLVITFICRIIFR---S----INLLT-----NIRNL------GKS-RVIVLI----FTEFFITFGLFFL------LNMICNICVCLQVAFNQINSRIAA------LTE-----TTKQLA-SSFEEI------RNLRHNYSYAVRSTQHAEKLFRCFITLFYIEYFTYNIMNVVKLFGP-RTKID------PIYFIYMFTQTLQLLILTYNLVLVNNLSRQGLEDLYEFSF---KLNSLHLYHENDIFIARMALSDVGFTFANLFTINNSFITSLLTLSLT------IILTLAS------FLYQ------TuGR280/1-345 ------M------NPEEP-RENH-LVEIK------CYYG------TYKRLFLFTVN--LI-CFALVIALYS-YT------WDFQLNS------K--M------NTFAM--CRATINI-ILV------SFRFIIILFL------IKR------HKTVSYLENLHEIG------VGQDC-QFKGFITRHQMCKNV------VFSIFVVIELALN---L----GHFFA------NYNLLGV-GEIVYF----FMLLIYPNVNLLI------IREIIGVSIYLQVAFKLVNSRVDS------LMS------KQAIDPNSL------KSYRRHYSYAVKATRSVENYFRCYVTFFYVQYACYNIMNIVCAFGP-HPSKN------IFWLFHFIVDTLLMIYLTIKLVSVNFLSRKSLDNLYEISF---ELDTMELKYENAIFMGRVLFTDVGFTFANLFTINTQFIASMMTLSLT------IILALAN------FLYE------TuGR279/1-344 ------M------DVEEAVQENI-LFKRK------SYFG------TYQRLFLFCTE--LF-CLISVITIYS-PA------YHHNLNS------K--F------DVYAL--CRITINI-ILA------TSHFIIVSAL------VKS------KKIASCFDNLYQIG------IHQDH-QLQRFITRKQWNKNI------VFSTFLILQYALH---L------FID------KKSLPVW-SKVIYF----IVLLVRPVTFIFI------LREIADVCIHLQAAFKLVNSKVNS------LVE------NQSINLESL------LLCRRYYSYAVKATKSVENYFRYYVTFYFVQYACYNIMNIVDAFGD-RSSMD------IYWVLHTISDTILMIYLTTKFVSLNLLPQESLENLCELSF---KIKRLDMKYENEIFIGRVLSTDVGFTFANLFTINTQFIASMLTLSLT------IILALAN------FLYQ------TuGR276/1-346 ------M------NAEEAVQENR-LFKRK------SYFG------TYKRLFLFCTE--LI-CLISIITINS-LY------FNLDLNS------K--L------GVYAL--CRVILNI-TLS------TSRFILILVLV-----VKS------KAKASYLDSLHSIG------VHKDH-ELKRFITQQQLYKNI------VFATFLILQYALD---V----WNYFN------IDINSVW-KMSFHT----ILVSAYPAIYLII------LREIVGVCIHLQAAFKLVNSKVDS------LVN------NQSTNLKSM------ICCRRYYSYAVKATKSVENYFRYFVTFYFVKYACYSIMNIVDAFGD-R-SMH------LYWVLHTIIDTLLMIYLTINLISVNLLSRESLDNLYELSF---KMKKMDMKYENEIFIGRVLFTDVGFTFANLFTINTQFIASMFTLSLT------IILALAN------FLYQ------TuGR277/1-345 ------M------NAEEAVQENR-LFKRK------SYFG------TYQRLFLFCTE--LI-CLISVITINS-LY------FNLDLNS------K--L------GVYAL--CRVILNI-TLS------TSRFILILVLV-----VKS------KAKASYLDSLHSIG------VHQDH-ELKRFITQQQLYKNI------VFATFLILQYATN---V----WHFIN------INIYSGL-RKSIHT----IMLFTFPAVYLLI------LREIVDVCIHLQAAFKLVNSKVNS------LLN------NQPTNLASL------TCCRLNYSYAVKATKAVENYFRYFVTFYFVKYACYSIINIVLTFGG---SND------TYWIFHTIVETLLMIYLTVYLVSVNLLSRKCLDSLYELSF---KMKRLDMKYENEIFIGRVLFTDVGFTFANLFTINTQFIASMFTLSLT------IILALAN------FLYQ------TuGR278/1-364 ------M------NIEEAVQENI-LFKRK------SYFG------TYQRLFLFCTE--LF-CLISVITIYS-PA------FYRKLNS------K--L------DVYVL--CRVTINI-ILA------ASRCIIVLVL------IKS------KKISSYLGNLHAIG------IHQDH-ELKRFITQQQLYKNI------AIATFTIIQYVLH---G----FNFIN------IDMNSVW-RKSIRV----ILLYTYQAIYLLI------LREVVDVCIHLQAAFKLVNSKVSS------LVN------NQSINLKSL------ICCRRYYTHAVKATKSVENYFRCFVTFYFIQYAFHNIMNIVNAFGG-RSSMD------IYWMFHTINDTLLMIYLTVNLVSINLLSRESLDNLYELSF---KMKRMDMKYENEIFIGRKI-TDVGFTFANLFTINTQFIVSMFTLSLT------IILALAKDEDQKNRENCLRNRFFFKSASKM------TuGR483/1-345 ------M------NAVEPVQENG-LLK-E------LYFG------TYQRLFLFWAE--LL-STIFNITVYS-FA------CNLELNS------K--L------DVYAL--CRTVLNI-ILP------ASRFILISIL------VKS------KEIASYFDNLYAIG------VHQDH-QLKRFITRKQLYKNI------VFLTLLIIKFVIL---L----CGFVE------KSSNPVW-RKVFYF----IMLSIQSVIYFFI------LREIVDVCIHLQAAFKLVNSKVSS------LVN------NQSINLESL------LCCRRYYSYAVKATKSVENYFRYFVTFFYLQYACYNIMNIVDAFGG-RSSMN------IYWMFYTIHDTLLTIYLTVNLVSINYLSRESLDNLYELSF---KMKRMDMKYENEIFIGRVLFTDVGFTFANLFTINTQFIASMFTLSLT------IILALAN------FLYQ------TuGR281/1-345 ------M------NVEEPVQENL-L-KKK------SYFG------PCQRLFLFWTE--LF-CLVLIITINVIYA------CNLKLNS------K--F------AVFAL--CRIVLNI-ILA------ASRFIIVLVL------IKS------KKKSSHLDNLYAIG------VHQKD-GLKRFITRKQLNKNI------ACSTLLFLKFVLH---V----WHSIN------TGIYFGW--KPIHA----ITHLIHPAIFFFI------TREIIEFCINLQAAFKLVNSKVNS------LVK------SQSIDFESL------IRCRRYYSFVVKATKSVENYFRYFVTFFYVHYAFYNIMNIVDAFGG-RSSMD------IYWIFHAIVDTLLMIYLTINLVSVNLLSRKCLDSLYELSF---KMKRLDMKYENEIFIGRVLFTDVGFTFANLFTINTQFIASMLTLSFT------IILALAN------FLYQ------TuGR290/1-349 ------M------ETEVVESIVFKGF-LVPLK------VILS------SHFRWFIAISL--II-FGLVRCVMQL-EE---DYVP------LG-----FYSGTYRT--IRMVINN-SNA------IIHIAVVLFA------LDW------SSFTHYLRQMSKLQ------LEKHE-KTVAQINKERRIKLL------FCLSSAIIYAVLI---C----YKLFLG----EIKV------NMFLLN----LSDCLTKMSHIFF------LNIISDVCICLKAAFQLVTSQLKD------FPK------STPDSTKLHRL------RYCRLLHSHAVRATRHAEKFLCFYISWYYFQYIMYNMANFVEVLGD-KHRYN------WRSGSFFIWDTINLSYLTIKLVAVSELSANGLEDLYEISY---DVNSIKLQFETHIFFNRMQLNNVGFTFAKLFFINTNFIASLLTLSLT------IVLALAN------FLQC------TuGR282/1-351 ------M-----DE------VQTESIVTKGF-LFKYD------LMLS------SFPRWLTVLSL--GF-CGLIRDTQWI-IK----L----PYCPMAS------K------FIDSQS--IRYMIHN-AVY------FSRFAIAMFA------LDW------TAFAEYTKQLSQME------LESDE-KSVKQIKRERRIKNW------FFVVSLISYPMIA---N---GCFLIL-----ELNVGI------YYIFSL----IIDSAYIGAHFFL------IYLIIDLSICLKAAFQYINHHLAH------FKI------TSPNSMLSEL------RRNRIMYSCAVRSSQEAEKFARHYIALFYSQFILFNINNIVDLLGQ-KRETS------LAFILFMALDIITAGYLTLNLVAVNKVSTEGMEDLYEISY---DLKSYNLQNENNLFLNRMLWHNVGFTVSNLFLINPNFITALLSFALT------IALTMAN------YLYK------TuGR283/1-348 ------M-----D------RSESIVTRGF-LLKYN------QMKS------SFPRWLIIFTL--GI-CDLIKNNRWL-TE------SFSPSVS------R------SQEFET--IRHCIDL-AIL------LSRSMIVTFA------LDW------TAFVQYAEQLSQME------LEIDD-GSVKQIKRERKLKNW------FCFVSLISYVMNY---K---NSFLML-----KLNMEI------YKIFSL----LVVIVSLAAHFFL------IYLIIDLCICLKAAFRYINNHLAR------FEE------TSPKRMLSEL------RRNRIMYSCAVRASQEAEKFARHYIAWFYFQFILFFIVNIVDILGP-KNAIS------VTFVLFMILDMITAGYLTLNLVAVNKVSTEGMEDLYEISY---DLKSYNLQNENNLFLNRMLWHNVGFTVSNLFLINPNFITALLSFVLT------IALTMAN------YLYK------TuGR286/1-350 ------M-----D------SKESIVTKGF-LVKYN------LMLS------PFPRWFIIFTL--GL-CGLIKNTRYL-IP----FLS--SSFSSAS------K------SIEFNT--IRYAIYI-VIL------LSRGVIVTFG------LDW------KAFAAYTEQLSRVE------LDKDE-ESVKRIDRERRIKNC------VCFFALLSYIMIT---I----SRSIP-----RIRMEV------NYLFIL----LNDIIILISNFYL------IYLIIDLSICLKAAFRFINHHLEH------FKI------TSPNSMLPKL------RQSRLLYSCAVRASQEAEKFARHYIAWCYFHFFLLSIVNIVEILSP-KGVES------IAFVLFMAFDIINTGYLTLNLVAVNSVSTEGMEDLYEISY---DLKSYNLQNENNLFLNRMLWQNVGFTFSNLFLINPNFITSLLSFSLT------IAIMIAN------FLYS------TuGR289/1-350 ------M-----D------SNESIVTKGF-LVKSD------LMFS------PLPRWFITLTL--GF-CGLIKDTSWI-IE----FLS--VIFSNEP------R------PREFAT--YRFMIGN-AVF------LSRCVIVTFA------LDW------KAFANFAKQLSRVE------LDKDE-ESVKQINKQRRIKNW------FFLISLIAYTVIT---S----TRYMP-----QLRTEI------YAVFLL----FVDIVMHIGNFFL------VHLIVDLCICLKAAFQYINQHLAH------FQI------TSPNLMLSEM------RRNRSLYTRTIRASQEAEKFARHYIAWFYFQFFLFNLVNIVNILGG-KSETS------IAFFLYMVLDITTAAYLTLNLVAVNKVSTEGMEDLYEISY---DLKSYNLHNENNLFLNRMLWRNVGFTFSNLFLINPNFVTSLLSFSLT------IALTMAN------FLYK------TuGR287/1-353 ------M-----E------RNDSIVTKGF-LVKYN------LMTS------PFPRWFLILTL--GL-FGLIKDTQWI-IKSV-SFLS--SIFSSES------R------HKDFDT--IRYAIYN-VVF------LSRCVIATFA------LDW------KAFAAYIEQLSRVE------LDKDE-ESVKRINRERRIKNC------VFFLSLISYIMIT---T----IRFLA-----GTRTEI------HNLFTL----LVDSSMHIGHFFL------LNLIVDLCVCLKAAFQYINHHLAH------FQI------SSPDPMLSEL------RRNRIMYSCTIRASKEAEKFARHYIAWFYFQFILFNIVNIVDLLGQ-KGETS------IAFVLFMALDIINTAYLTLKLVAVNSVSTDGMEDLYEISF---DLKSYNLQNENNLFLNRMLWRNVGFTFSNLFLINPNFITSLLSFSLT------IALMIAN------FLRS------TuGR288/1-346 ------M-----E------RNESIVTKGF-LVKSN------LMLT------HFPRWFMILTL--GF-CGFIKETLWI-VQ----FI------SSVS------R------PRDFET--IRFTIYN-VVF------LSRCVIATFT------LDW------KAFAAYIEQLSRVE------LEKDD-ESVKRINRERRVKKW------FCFVALLSYIILN---I----IHFVT-----LLRKES------YTVSIL----IVDIVLFISHFFL------IYLIIDLCICLKVAFQYINHHLKH------FQI------TSPNLMLSEL------RHIRSMYSCTVRASQEAEKFARHFIAWFYCQFILFNIANIVDLLGQ-RNEKS------IIFFLFMVVDGINTGYLTMKLVAVNKASTSGMEDLYEISY---DLKSYNLQNENNLFLNRMLWQNVGFTFSDLFLINPSFITSLLSFVLS------IALMIAN------FLYH------TuGR284/1-349 ------M-----D------SNESIVTKGF-LLNYN------RMTS------SFPRWLMIFTL--GF-CGLIKDSLWN-IE----FV---SILSSES------K------PSEFVS--IRYAIYN-VVM------LSRCVIVTFA------LDW------KAFATFTEQLTLVE------LDKDE-DSVKRINRERRVKNW------FCSVSLIAYIMIN---I----FYLVT-----QPRIEC------FYLFTL----LVNTILYIGDFFL------IHLIVDLCICLKVAFRGINNHLAH------FQI------TSPNVMLSEL------RRNRSLYSCTIRASREAEKFARHYIAWFYCQFFLLSIVNIVNILGL-KSKTS------LAFVLFMAFDIINTGYLTLNLVAVNKVSTEGIEDLYEISY---DLKYYNLHNENNLFLNRMLWRNVGFTFSNLFLINPNFITSLLSFSFT------IALMIAN------FLGS------TuGR285/1-350 ------M-----D------RNESIVAKGF-LVKYN------LMLS------PFPRWFIIFTL--GF-CGFIKSIRRI-LA----LLS--FSSSMEP------R------SQVFDI--IRYGIYV-AIL------LSRCVIVTFG------LDW------KAFAAYIEQLSRLE------LEKDV-ESVKQIKRERKLKNW------FCFVSLLSYMMIM---L----TSPVN-----RRRSGI------DLICET----FVDLILLIAHFSL------VHLIIDLCICLNVAFQYVNHHLAN------FQI------NSADPMLSEL------RSNRLFYSCTIRASQEAEKFARHFIAWFYCQFILFNIVNIVDILGP-NVETG------VTYGLFMVLDIINLAYLTVKLVAVNKASTQGMEDLYEISY---GLKSYSLQNENNLFLNRMLWQNVGFTFSDLFLINPNFITSLLSFVLT------IALMIAN------FLYK------TuGR295/1-358 ------M------AYRGQDRN------NFGISENRSFLLNGY-IIGEQ------RIKK------LYLKWILGTTI--VL-LMPIGQFYRC-FL----TF---YYPEYGS------I------SRNVNY--ISMLLNL------T----ITLTQAIIIFR------LNW------DYFWSYIDSLELLN------IPSYD-KLRKQIQRKRIVKIF------MFASILLIYKAPEF--I----YTPWH------YNRFTI----IFHLARYVGHFFI------FIILIDICICLQAAFESVNKQIVS------CCY------NNKQRLLLKHL------LYYRQCWFHALEATQSAEKFLRHYVTFFYVRFAVHTVLNQIHLFHHLKSSQF---SDVFYFLIVTFTNAILVWYITANMIAVNTFSQNSLEELYELTF---KTDSIILEQQIYMFLDQISKTDAGFTFGNLFLIAPNFITSFFTLTLT------ITIAFLS------YL------TuGR291/1-349 ------M------DPSCIKSGFL-FG------R------PKLTRWIVTSL--FV-ILLIAAIFSW-FI----TT------KVCLK------SDSPLKCL-IFVGQND-LIA------SLRSLVAIFG------FEW------SSLNKFISLLSNLR------IDNDC-DSIRFMDKSRKLKSI------LFFAIFCSLSFIS---L----KPLFF------GPSGDYF-IKYFYS----IFAIYNIISALYI------LSIMIELCICLQAVFRFLNRQIVH------LHQVS-L-TRHEPRSSLKYEL------KIYRYHYSLGIHLMKAADRFARVYVTWFYTEYAYYSILHVYSRLIF-KSGS------FVQLMFGATSFVGMSYLTLNLIHVNTQSNNILEQLYEISF---HSYDLSFRQQLDFCLYRLSKRDVGFTYGNMFVITPNFITSLATITLS------IVLAIPN------VLKLSG------TuGR292/1-371 ------M------VEGI-TIEIQ------KILNLLA--IYPYVDEF-----SEYKSYPKWLIIITL--GV-LSFLHGLHSC-YW----SFI--YLCHFES------T--F------TSITKC--LYDIHYD-LIS------IIRGLVVLFM------FDW------AALDNHVSITQKVW------LKMDQ-KSHEFIIKSRRFKLI------VMTFSSLNDLIWTL--V---GAYLFPTD-SEDFKDRPSI------YKYVIA----VCEFVTVMGWLFM------LNMISEICINLQAMFAMINQKLTD------HPF------NIDHLTDQI------KIYRSYYSLTIRATQSAETFLCYYLTIVYIEFIYSNLVNNIFNLASPTNSLA----DSLQILCYNLSTTTYLFYLTYNLIKVNYFSHKGSEDLYELSL---LTDDNQCKQEIELFLYRMSKKDVGFTFSKLFVITPNFITSLFTLALT------LILASPS------FKLNPD------TuGR293/1-338 ------M------K------KYSSTHIGLCL-AGL-CGIAAGLIAG-FR----SFD-QGSCKPSS------S--F------RIYRC--LFMITVE-IDD------ILRGFILICG------YNW------KSLEQANQLMENFN------LLENE-TVAVSEKKRRRIKLF------VVFYLNLYYPIFLL--IV---TFYIQ-----DFKSDTRT------KLIFLF-TVNVTRLISIFGWLYA------YNKFCGAVIKLIGCFELINIQLKN------LKN------VTGVTKRL------NRLRLMYSLAVRASVHLEDFARFEIAHLYTIATISNFTNIYTIYGE-NSSLR----RKLISCLFMCGDAVYIIYITIIMMRVNTVSYEESETLYELSL---LNEPDNLNREIELFLYRVSKNDVGFTFLNLFVINPSFISSVITLFTT------FILTLPS------LY------TuGR399/1-368 ------M-----V------D----IEANS------QNGQHEPISVFGRAF-IR------K------NLSSQVIFWIS--LI-SMVARGFYIL-YH----VF------DPTIS---LYNSD--V------FKYQR----ITCQL-YSI------SVGLILLHLK------YNR------SLYIDYLDVYQTLV------S-DNFGL-ASTGFVRKQNQIKRF------FPIIAIIYEILTIL--I----HQYSF-----DLPKLGFS------L-KLIAAF----IIASIAQCGYVFS------MQFIIECCIYSQSSLMSMNNLLDS------LIH-----KRIEPS-NNMNHIA------MSIRLYYSKTVESIRLMDKFLTFAIFVFYFYFTGHCVLIVGEILDT-DSSIY----FILWLIFNLFGELSYLVLITYHLVSVNQNSARIFDKVYQISFSLNSSHSIQTMNEINLLLLRINRNDVGFTFAGLCMVSPSFISSLATISLT------LGLALPS------FIDDK------TuGR400/1-367 ------M-----V------D----IESNR------QNGQHEPISIFGRAF-IR------E------NVTSQVIFWIT--SL-GITAKGLYKL-YR----VF------DPTIQQDSPHSRG--V------VKYEL----IYTQL-HSI------SFGLIILHFK------FNR------SMYLKYLDIYQTIV------R-SNFGL-ASNGFKKRCIKINRF------FLVFATIYEMLTTS--V----NHYLS------DRPTDFS------I-VFFVEL----ILMAFALFGYVFS------MQFIIECCTYSQSSFKPLNNLLDS------LLN------KSLPNNMNSIA------KSLRLYYSKTVESVRIMDKFLAFAIFVFYLYFTGHCILIVGEILDASRCSIY----YTLWMIFRFFGESSYLVLITYHLVCVNQSSTRIFDKVYQLSFSLDSSHSIVTMNEINLFLLRTNRNDVGFTFAGLCMVSPSFVSSLATISLT------LGLALPS------FIK------TuGR388/1-366 ------M-----D------Q----VKSIY------SDPQTEPSSLLGCSL-VR------K------NVSSQVTFWVA--SI-SLISKAVYRL-YF----IF------TTGID---HREPP--I------IRYEQ----LLIQM-YSL------CLGLTIMNFE------FNR------SVYITYLDCYQTIV------S-EHFSK-SSSKFVNKWVKIIRF------WVLIAFLYELTTIT--I----HTYLR-----YFHKIGLQ------V-NFFATI----LVVLISQVSYILS------MQFIIECCIYCQATFIPINTLLNN------FLH-----QNKHSTPIKMYRMA------RVTRSYYFETIKSIRYMDKFLAFAVLVFYFYFSGRCIFLFGRFFQG-SSTIY----LQIYNFFRFFGEASYLVLVTYHLARVNRLSVKIFDKVYALTHSSNSD-SVESINEINLFLLRIDRNDVGFTFAGLCLVSPSFVSSLATISLT------VGLALPN------LFK------TuGR395/1-368 ------M-----D------E----IKSTY------FHSQNVPFSLIGCSL-VR------K------NVFSQVIFWIA--SI-GLIFNALYTI-YF----TI------SPVIH---VHGAS--I------GEYEE----ILYQV-FCL------CLGLITMRFE------INR------SSYIKYMDFYQTIV------A-NNFGK-ASPKFVKKWGRNIRL------WVAFAFIYETITSS--T----NTYM------YFQKFILP------V-NMFATI----AIGLIAQLSYILS------IQFMIECCIYCQSTFIPINALLDT------LLN-----QNKHSSPIAFRRMA------RSTRVYYIKTIKSIGYMDRFLAYAIFVFYFQFIGHCIFIFSSTFAN-GQSLF----MLCYSVFRFFGEGSYLVLVTYHLIRVNQLSVQIFDKVYQLSFSFNSDQSIEAINEINLFLLRINRNDVGFTFADLCLVSPSFASSLVTISVT------LGLALPS------IIKSH------TuGR391/1-366 ------M-----D------E----IKPTY------SDSQTEPFSLLGCSL-VR------K------NVFSQVMFWIV--SI-GLIFNASYRI-LF----II------FPAFH---VNEAT--T------DKYEE----TFYQV-FSL------CLGLITMHFE------LNR------SLYIKYMDSYQTIV------S-NHFGK-ASPKFVKKWGRIIRF------WVIFAFIYEVVTSS--A----SDYS------YFQKFSLQ------V-NMFATI----SIGIISQLCYILS------MQFIIECCIYCQATFIPINTLLDT------LSN-----QNKHYSPLDINRMA------RSTRVYYIKAIKSIRYMNKFLAYAILVFYLHFIGHCIFIFSSTFAI-GQSAF----MLCYSVFRMFGEGSYLVLVTYHLIRVNQLSVQIFDRVYQLSFSFNSDQSIEAINEINLFLLRINRNDVGFTFAGLCLVSPSFVSSLATISLT------LGLALPS------ILK------TuGR392/1-365 ------M-----D------E----IKSNY------YNSQTGPCSLISCSL-VR------K------NVFSQVMLWIV--SI-GLIFNASYRI-YF----II------PAIQ---AHETT--T------VKYDQ----ILDQM-YSL------CLGLITMHFE------LNR------SLYIKYLDCYQTII------G-NHFGA-DSSKFVHKWVKIIRF------WVIFAFIYEVVTSS--I----NDYS------YFQEFSLQ------V-NMFATI----SIGIICQLCYILS------MQFIIECCIYCQATFIPINTLLDT------LSN-----QNKRSSSTDVNRMA------KSTRVYYIKTIKSIEYMDRFLAYAISVFYLYFIGHCVFVFSSTLNI-GDSSY----MLFYSIFRFFGESSYLVLVTYHLIRVNQLSVQIFDKVYQLSFSFNSDQSIEAINEINLFLFRINRNDVGFTFAGLCLVSPSFVSSLSTISLT------LGLALPS------ILK------TuGR394/1-369 ------M-----D------E----IKSNP------CHSQTEPSSLLGCSL-VR------K------NVFSQVVFWVA--SI-ALISKAVYRL-YL----AI------ITPID---VSEPTTVI------NSYEN----ILNQM-YAL------CLGLIIMHFE------VNR------SLYIEYLDCYQTIV------S-NHFGK-ASLEFVKKWVKIIRF------YVIVAFIYEVITTS--T----NNYLR-----YFNKFGFT------L-NMGAII----FFDWIVQLSYIFS------LQFVMECCIYCQSTFIPINALLDT------LLN-----RNKLSSPLTINRMA------KSTRLYYIKTIKSIIYMDKFLSYAVLVFYLYFIGHCIFIFSSTLNI-GHSLY----MLCYSVFRFFGESSYLVLVTYHLIRVNQLSVQIFDKVYQLSFSFSSDQSIAAVNEINLFLLRVNRNDVGFTFAGLCLVSPSFVSSLATISLT------LGLALPS------FSR------TuGR393/1-369 ------M-----D------E----IKSNH------CHSQTEPSSLLGCSL-LR------K------NVFSQVVFWIA--SI-TLVSKAVYRL-YL----VI------ITPID---VSEPTNFI------NRYEL----ILDQL-YPL------CLGLIIMHFE------VNR------SLYIEYLDCYHLIV------S-NHFGK-ASLGFVKKWVKIIRF------WVIVAFIYEVITTL--T----NNYLR-----YFKKFGFT------V-NMFAIL----SIGLIGQLSYILA------IQFMIECCIYCQSTFIPINTLLDT------LST-----RNKLSSPLDINRIA------KSTRVYYIKTIRSIRYMDRFLAYAIFVFYLYFIGHCIFIFSSTLKI-GSSPY----LLFYSVFRFFGESSYLVLVTYHLIRVNQLSVQIFDKVYQFSFSFNSEQSIVTVNEINLFLLRIHPNDVGFTFAGLCLVSPSFVSSLVTISLT------LGLALPS------IIK------TuGR644/1-362 ------M-----D------E----IKSNY------CHSQIEPSSLLGCSL-LR------K------NVFSQVVFWVA--SI-ALISKAVYRL-YL----VI------TTSIE---VSEPTDFI------HRYEN----ILDQL-YPL------CLGLIIMHFE------LNC------SLYIKHLDCYHLIV------S-NHFGK-ASLEFVKKWVKTIRF------WVIVAFIYEAVTTS--T----NNYLR-----YFNKFGFT------V-NMFAIV----SIELIGQLSYILA------IQFMIECCIYCQSTFIPSNTLLDT------LSN-----RNKLSSPLDINRMA------KSTRVYYIKTIKSIRYMDRFLAYAILVFYLYFIGHCIFVFSSTLNI-GSSPY----MLCYSVFRFFGESSYLVPVTYHLIRVNQLSVQIFDKVYQLSFSFNSDQSIEAINEINLFLLRINRNDVGFTFADLCLVSPSFVSSLVSISFN------FCY------TuGR390/1-363 ------M-----D------E----IKSTY------SPSQFEPSSLLGWSL-LR------K------KVFSHLMFWIA--SA-SLISRAFYRF-SI----VV------MN---KEVET--M------TKYGQ----LLNQL-CTL------CLGLTIMHFE------FNR------PLYIKYLDCYQTIV------N-NNFGK-ASLKFVNKWGKIVRV------WVIFAFLYELITIA--T----FEYLY-----IFKKTGFT------A-NMFLLV----SFFSFTQLLYILT------IQFIIECCIYTQSTFIPINTLLDT------LLH-----QNQQSTQLDINRMA------KLTRVHYTKIIKSIRYIDKFLTYAILVFYLYFIGHCIFVFNEFFQV-SGSIY----WRLYNVFRFFGESSYLVLTTYHLVRVHQLSVQMFAKVYDLSYSL-ASDSFEAVNEINLFLFRIDRNDVGFTFAGLCLVSPSFVSSLASIALT------LGLALPN------FID------TuGR397/1-368 ------M-----D------A----IESTHN------GNGQHEPISILGYLL-VRI------NK------NVSSKIIIWVC--SA-LMIFKTFYRL-YS----IF------DPTIS---LYDDN--I------VKYEK----IYNQL-YAL------SLGLILLNFY------MDY------SMYIKYLNAYKRIV------K-NGFDI-DSTEYVEKQLKINRL------FIKLAFICELAITG--Y----NNYLN-----YYRKLGFR------S-EMIFLS----VTACITQCSSLIF------VQFIIECCIYCQSSFIPLNNSLDI------IIR-----QNERS--IDINRIA------KLIRLSYDKTTESIRCMDKFLTFVLFAFYSYYIGHCIFAFGIILSY-ASSFY----FLSFAVLRFLVDAFYLFWVTYHLVRVNQLSIQMFDKVYRLSFSLDSSHTIATMNEINLFLLRTNRNDVGFTFAGLCMVSPSFVSSLATISLT------LGLALPS------FIK------TuGR398/1-364 ------M-----D------E----TASVVI------HNSLHKPTSILGRLL-VNL------NK------NVLNKIIIWTI--SA-SLIVQAFLKL-YW----DS------DSNFI---IY-NN--I------MKYEK----LYSQL-YGL------CLGLTLLHLT------SHH------SFYIKYFNVYQTIV------K-NGYGS-DVTKFLSKKTKTIQS------FLKLATICG------NNYFN-----FYLKSGFN------S-YMIIVS----IVSCTFQMLYALF------LQFIIECTIYCQSSFIPLNNLLDA------FMRQ----QNNRSTPINIDGVA------RIIRLHYKKTTKSINCMNTFLTVAICTFYLYFIGHCIFAFGIILSY-TSSTN----LLSYAITRFLGGTCYLVFTTYHLVRVNQLSVQMFDRVYDFSFSLNSSHSIITMNEINLFLLRVNRNDVGFTFAGLCLVSPSFVSSLATISLS------IGLALPS------FIK------TuGR396/1-376 ------M-----D------H----LNNEES---SS---LDGFYTQHKPFSIFGALL-VR------K------SISHQIIFCFT--SV-LLITKAFCRL-YM----IF------DPTISRVTTADYS--F------VKYEK----TLKQL-NSL------LVGLVILHFM------FNR------QLYIRYLNVYYSIA------K-NNFGL-FSTEFVVKWTKFNQL------FLTLALIVQLIITL--D----NYYVH-----YFNEFGFS------L-NMIVYS----IVVYTAKCIEILA------IQFIIECCFYSQSTFLPLIDSLDT------LAQ-----SNNRPSQSDINRIT------KSIRLYYSETIRSIRYMDRYLTYAILVFYSYFIGHCIFLFGTLFYS-NQSTY----IFFMSVFEFCIKSLYLFLVTYHLIRVNQLSVQMFDKVYDLSYSLNADLSRRSINEINLFLLRIGRNDVGFTLAGLCLVSPSFVSSVATISLT------IGLALPN------FIK------TuGR381/1-370 ------M-----D------K----NKLTR------RSKLTRPLSLFGKSL-LG------NKWSQIIHIFT--AI-FSLILSMGKL-YD----IY------DDIKNG--RYDNV--L------LKYER----IMNFI-VCL------SISCISLNYI------FNK------SYYIEFINLHSKIA------NSDYFGL-FCNSHLTKWMKINHL------FFVSFISFEVPFE---I----VYFIH--DYILLEGFT------FSSTLH----LLSLVLSFKVCFL------YEFIFETCTYLQSDFILLDNLLVQ------LST------QTHQTNEINV------KSLRLLHNEIIKCTGLINKLFKYAVLCTYAYQIGHNVCLIGILSL--DQFNS----YLAIFIIKFIEQSIMLTLITYHLVRVYQLSVQLFDKVYHLSFSLNPSHSITTTNELNLFLLRINRNDIGFSFVGLCMVSPSFVSSLATISAT------LGLAMPS------LIKSSAYEG------IK TuGR382/1-362 ------M-----D------E----HKSSY------RSTLTRPSSIVGKSL-LR------E------NKWSQILHLFP--TI-VLLVVSIMKL-PN----IY------NDIKTN--RYNNV--L------IKYER----IMNFI-VYL------SLSLVSLNYK------YES------SYYIEFINLYQKIT------NTNYFGL-FCNSYLIKWSKINKS------IVLILALSGLFVN------LLFIG--NRISLSEPI------SSLNLI----FLIVVASFNVPLW------FQILFEICTFLQSTFLLLENSLVR------LKK------QTNQLNEFNV------KSLRLLHVQIIESIIIINKFYRYNILSTYVYSVGHNVCLLGILSHS-GQSIS-----KFPYYVKFIEQLFHLMLITFHMVRVNQLSVRVFDRVYKLSLSLNSSHSTATMNEINLFLLRIHRNDVGFTFAGLCLIAPSFISSLASIALT------IGLALPS------LVE------TuGR383/1-370 ------M-----D------Y----NKLRKF------IEKSTKPSSIFAKSL-FR------E------NIVSQVVQLCT--SI-SFLLYALVKL-YK----IH------DSSKNTP------LGVD---RGNFTYNNC-TRIANFF-YAI------SVSAAILLYK------YNS------KKYVNYINYFQSSI------K-NPFGL-KQILYVNKWQKINRF------IIILLSLTGLTIMT--L----EFYYH-----PFSLT------YDYAEI----ILTYMCESGLILE------QQFVLETCIYLQSNFVFFHLFFDS------LTK-----KVIENLRVDVYHAI------KSVRDIHSQTIEFTRQLDSFFRLKVLNTFGYLAIYSICNIGLLAAP-DQTMI----RILTLIGRAIFIATILCLSSYHFARVNYLSIQVYNKVHDFSLSRNLIRSIETMNEIKLFLLRISRDDVGFTLAGQCVVSVNFISSLAIITLT------IGLALPG------FFK------TuGR386/1-376 ------M-----D------Y----NKLMKI------IEKSTKPSSIFAKSI-LR------E------NISSQVLHLFT--SI-SFLLLCTIKL-YK----IH------ESSKNTP------LGIN---IGALTYSRC-ERIVNFF-VIL------SFGVTSLLYK------YNS------PTYARFINDFQSSI------NKNCFGL-TQITYIKKWIKFNRF------ILTLQSITRILILT--L----HFSYN-----PFSWTF------INSLNF----VLPFMCESGMILE------QQFILETCIYLQSNFVFFHLFFDS------LTK-----KVNESPGVDVYHVI------KSVRRMHSRTIEFTRHIDSFFRFTVFNTFLFLTIYFICIIGMLLAP-DQTLI----RILNLISRAIFISITLCVSSYHFARVNYLSLQVFNKVHDLSLSPNLVRSIETMNEINLFLLRISRDDVGLTFGGLCLVSVNFISSAAIIALT------IGLALPS------FFNSNST------TuGR384/1-391 ------MHLVDSKVSQISLFGVCFSVKM-----D------T----NNLIGF------IEKSTKPSSIFAKSL-LR------E------SISSQLLHLFT--SI-SFLLYATTKI-YK----IH------KSTKNTH------LGIS---ISDLTYNKC-IIIANIL-YTS------SLVATILLYK------YNA------HIYVKYINDFQSSI------K-TPFGL-AQTSYVNKWQKIDRF------IVRLQFLTRITVRA--V----EYYAN-----PFNLT------YSYTDI----VVSFMCELSLILE------QQFIHETCIYLQSDFVYYHLFFDS------LTK-----MVNESVGLDVYHAI------KSVRHMHSQTIQFSRKIDSFFRLTLLNTLGFLTIYSICNIGLILAP-NQTMM----RVLTIIGKAILFLAILSVSVYHFARVNYLSLQIFNKVYDLSLSPNLVRSIETMNEINLFLFRIRRDDVGFTFAGLCVVSVNFISSLAIIALT------IGLALPG------FFK------TuGR385/1-369 ------M-----D------S----NELKDI------IEKSTKPSSIYAKSI-LR------E------NISSQVVHLFT--SI-SFLLYATVKL------IN------EFSKNTP------LGIK---ISTLTYDRC-IIIANFL-FST------SLFATILLYK------YKG------PIYVEYINYFQSSI------KNGSCGL-AQASYVNKWQKINRF------IIILQLLIRITMRF--F----EYYAN-----PFHLT------YNYIDI----ILSYMCELGLILE------QQFIYETCIYLQSNFIFFHFFLDS------LTK-----KVNESPGVDVYHVI------KLVRHMHSHTIEFTRRIDPFFRLTVFNTFGFLSVYSICIIGMLSAT-DQTIS----QILILIGRATYFATLIFVTSYHFARVNYLSMQICNTVHGFTLSPNLARSIDTMNEINLFLLRISRDDVGFTFAGLCVVSVNFISSLAIITLT------IGLALPG------IFK------TuGR387/1-374 ------ML----T------E----NKVAS------ENSSDKPSSILMQSI-LQ------S------NKSTRCVHLLV--SA-GYIVKGSLGL-YN----NL------VQQSNL--SGAKN--L------AKFAQ----IWNKL-YAL------SLGFTLLHLI------LNK------SNFTKFWVHLQTIK------N-KSNGF-SVSKYLHKWNLINRI------CVVAAIIYELIIIAIEI----NNHRQ-----KYSLFKLN------Q-PQLWYC----LTLFISQSGWVLF------FQFMIETAVHLQSAFIIIEDRLES------LQSLE-LNYIQSVNDYGFDSLV------RSVRSIYIEVINCSRLINTYLSTAITAFYLYFVGYCLCIFSNLF---DQSTD----SLLVNIIRLTGGSMYLFWLTYHLVQVNKLSVKIFDKVYALSFLPVRSRLSQFINEVDLFIIRIDRHDVGFTFAHLAVITPSFVSSLLTISLT------LGLALPS------LLKL------TuGR378/1-373 ------ML----SF-----S----VQNIVN------IKKPIQPSSILSQSI-LR------K------SKSARIVHLAV--SL-GFVLRSFTVY-YD----LT------SEDGISK-ASSNN--I------SKYYA----IWLLI-YSF------VFPCSLIALI------FNS------THYFEFLNIWKNIV------KRNEN-VINAYITTKRKFSYR------IILLAFIYETALN---F----IQLIQ-----LVDLLT------RNNFSLY-FQVIRIGSQVLVLISIAFGWSLF------MYFILETCIYMHSAFVLIDYHLDN------NKL------NQLDSNDIEQI------ILARNTYSESIKLISCADNLLSFLITGFYIFFVGYCFAIIGQFSMS-DGTFI----DVLTVIFRLFGETIYIGSMTHYLVNINKLSDKIFEKVYSLTL--NRSRTVEYNDEINLFLLRVGRNDVGFRFANLFVMTPAFVSSLATISLT------LVLTLPS------LLH------TuGR689/1-373 ------ML----PF-----S----VQNIVN------IKKPIQPSSILSQSI-LR------K------SKSARIVHLAV--SL-GFVLRSFTVY-YD----LT------SEDGISK-ASSNN--I------SKYYA----IWLLI-YSF------VFPCSLIALI------FNS------THYFEFLNIWKNIV------KRNEN-VINAYITTKRKFSYR------IILLAFIYETALN---F----IQVIQ-----LVDLLT------RNNFSLY-FQVIRIGSQVLVLISIAFGWSLF------MYFILETCIYMHSAFVLIDYHLDN------NKL------NQLDSNDIEQI------ILARNTYSESIKLISCADNLLSFLITGFYIFFVGYCFAIIGQFSMS-DGTFI----DVLTVIFRLFGETIYIGSMTHYLVNINKLSDKIFEKVYSLTL--NRSRTVEYNDEINLFLLRVGRNDVGFRFANLFVMTPAFVSSLATISLT------LVLTLPS------LLH------TuGR379/1-372 ------ML----SF-----S----VQNTVD------IEKPIQPSSILSQSI-LR------K------SASKRIIHLAI--SL-GFMLRSFIIY-YD----LT------IEDGII--KASSN--L------SKYYA----IWKLI-YSF------VFPCSLIALI------FNS------NHYIEFLNIWTNIV------HRNEN-IINAYITSNRKFIYR------IILMAFIYEAAVN---V----IQLIQ-----LVDMIT------RNNFSMY-FQVIRIGSQVLVSISIVFGWSLF------VYFILETCIYIHSTFILIDNHFDN------KKH------NQLDSNNIEQI------ILARSTYSESIKLISCAEKLLSFLITGFYIYYVGYCLGIIGQFSVS-EGTFM----DVLTVIFRLLGETIYIGSITHYLVHINKLSDKIFEKVYSLTL--NRSRTVEYNDEINLFLLRVGRNDVGFRFANLFVMTPAFVSSLATISLT------LVLTLPS------LLH------TuGR375/1-374 ------M-----STIT------FANSIK------KSILVQPSSILAQSV-SK------K------NLTTRIIHLVL--SI-AYAMRGFFEC-YL----IF------NKLFTN--GFPND--I------VKYDT----LWRFA-YRL------ITTYTYFSLM------INQ------SLYNKFLASCATIV------HGYES-VANEFVVTKKATMNK------LVVIFFVYEILIDSAVV------DNSRISKAF--FTINFSHI-KLITYY----ILMVTDAACWSCF------VHFVIETCVYLQATFYVISARIEN------LDS-----MCATISEENIVPLL------KRNRSLFMKATEASKCIDSFFFLITFSYYVYFALNCIFSFDFFFESIYDSWY----MLIRHLIRMIGEFSYMLIVTYAFVHVNQLSVGIFDKVYSLTL--TKSGSFEYSNEINLFLLRVGRFDAGFTFAGLFVITPSFVSSLATISLT------LGLAIPS------LFH------TuGR376/1-374 ------M-----STIL------FVNSFE------NDDMVQPSSVLAQSV-LR------K------NLTTRIIHLVL--LI-SHAMKGLFES-YF----IF------NQLSTN--GFTNS--I------VKYET----LWRFA-YRF------IITYTYFSLM------INQ------SLYNKFLASCHAIV------HGYES-VANEFVVTKKAMISK------LVFIFFVYEILMDLTIV------DHSRVSKAF--FTIRYSYL-KLIAYY----IFIVTDSACWSCF------VHFIIETCVYLQATFYVISSRIEN------LDS-----MCATISEENIVPLL------RLNRSLYMKTTEASKCINSFFFTITFSYYVYFALNCIFTFDFFFEPIYDSWY----MLVRHLIRMIGQFSYMLIVTYAFVHVNQLSVGIFDKVYSLTL--TKSGSFEYSNEINLFLLRVGRFDAGFTFAGLFVITPSFVSSLATISLT------LGLAIPT------LFH------TuGR377/1-382 ------MKVIISPLIFVE------M-----STII------FVNSFE------NDSLVQPSSVLAQSV-LK------K------NLTTRIIHLVL--LI-AYAMKVSCES-YL----IF------NQLFIN--GFTNS--I------VKYKT----LWRFS-YRF------IIAYIYFSLM------INQ------SLYNKFFVSCHAII------HGYES-VANEFVVRKKATMKK------LVFIFFVYEILI----V------DSSRILKAF--LTVNYSQI-KLITYY----ILIVTNAACWTCF------VHFIIETCVYLQATFYVISARIEN------LDS-----MFSTIREENIAPLL------RLNRLLYVKATDASKCINSFFFLIIFSYYVYFALNCIFSFDFFFESIKDSWY----MLIRHLIRMIGQFSYMLIVTYAFIHVNQLSVGIFDKVYSLTL--TTSGSFEYSNEINLFLLRVGRFDAGFTFAGLFVITPSFVSSLATISLT------LGLAIPS------LFR------TuGR380/1-371 ------MY----SL-----A----FQHKTR------GHQFIKPLNIFAKSI-IF------K------SRFHQAAHLII--LV-AFVTRGLFGI-YI----LL-----TDSQSTT--ISQTH--V------VKWLI----VWRSV-YSF------IFALSLAQFS------VKS------HLYKRFFQNWQEII------RQNPL-IANNFIIKKRKALTI------IIITLFVYELLTV---T----YDFIA-----LENSSP------STRIDIL-KQTLQY----TFTIIISTGWAAY------IHFLVESCIYLQSTFKMINYYLKN------FELI----KLLPSKFNASHKI------RSIRRLYAQSVELIDLIDTFLSFTIFGFYIYFTVYCLFIFSLLFSS-SKTTA----DLIMSIIKCIGESSYIIIVTYYLVHIHTQATQIFDKVYNLTLT--KLAEYEYTNEINLFLVRVNQQDVGFKFARLFVIKPSFVSSLATVSLT------LALTIPN------VF------TuGR371/1-370 ------M-----P------E----IRHWNQ------STTISSPSSIIIKAI-LQ------K------DRFSQFLYAFL--IF-LYMVRFFYPT-YM----VL-----FDSSSFY--LLNNN--L------VKFES----LLNTF-YIG------YNCLVLIHAF------YTR------SLYAQFMKTLHEIL------DDNSF-VANEHINISQSTILK------MLACMCVYECTSDI--IRSDLKTMLN-----DFATLN------Y-SNIILH----GILFLATFTWLSI------VHLIIESCMYLQSVFIVIDNHLLH------YQT------NLHIIGSNHHVL------MSIRSVYMKAIIATRQLDKFNRYLIFGFYVYYTGYCLTIFGRFFYV-ANGST------AGNFIRFIGESAYVAVVTYYLVRINKLSISVYDRVYSFTL--MKNKTNEFIHEVNFFLMRINQHDVGFTFGGLCIITTNFVSTILTIALT------LGLGLPS------LFTQMDHL------TuGR374/1-365 ------M-----S------E----ETIGHQ------PTIIASPLSIISKAI-LQ------K------NRFSQFLYAFL--LF-IYMVRFFYPT-YL----VL-----FESASLY--LLNNN--L------VKFES----LWIAF-YTG------YNCLILIYAF------YSR------SLYAQFMETAHEIL------DNNSF-VANEHIIKSQSTILK------MLACMCVYECTSDI--IKSDLKTMLN-----DFAALN------Y-SNIILH----GIRFLATFAWVST------VHFIIESCMYLQSVFIVIDKYLEY------YQT------NLHIIGSNHNVL------MSIRSVYMKVIIATRHIDKFNRYLIFGFYVYYTGYCLTLFGRFFFV-ANGSA------AGNFIRFIGESAYVAVVTYYLVRINKLSISVYDRVYSFTL--MKNKTIEFIHEVKFFLMRINQHDVGFTFGGLCIITTNFVSTILTIALT------LGLGLPS------LFP------TuGR373/1-365 ------M-----S------E----EGIGHQ------STTISSPTSIFSKAI-LK------K------DRFSQFLYPFL--IL-ICMVRFFITS-YL----VL-----FDSSSLY--LLNNN--L------VKFES----LWNAF-YIG------YNCLILIYAF------YAR------KLYAQFMETLHEIL------DYNEF-VANEHIVKSQSTMLK------MCAFICVYEFTAEI--IKSSPKKMLN-----DFATLN------Y-FNIIYH----GIMFLSIFYWIST------VHFIIESCMYLQSVFIVIDNHLLH------YQT------NLHIIGSNHNVL------MSIRSVYMKAIIATRQLDKFNRYLIFGFYVYYTGYCLTIFGRFFYV-ANGST------AGNFIRFIGESAYVAVVTYYLVRINKLSISVYDRVYSFTL--MKNKTNEFIHEVNFFLMRINQHDVGFTFGGLCIITTNFVSTILTIALT------LGLGLPS------LFT------TuGR372/1-365 ------M-----S------E----EGIGHQ------STTISSPTSIFSKAI-LQ------K------DRFSQFLYPVL--IL-ICMVRFFITS-YL----VL-----FDSSSLY--LLNNN--L------VKFES----LWNAF-YIG------NNCLVLIHAF------YAR------KLYTQFMETLHEIL------DNNSF-VANEHIIKSQSTILK------MCAFMCVYEFTAEI--IKSDPKTMLN-----DFTNSN------Y-FNIIYH----GILFLSIFTWVSI------VHFIIESCMHLQSVFIVIDKYLEY------YQT------NLHIIGSNHHVL------MSIRSVYMKAIIATRQLDKFNRYLIFGFYVYYTGYCLTLFGRFFYV-ANGST------AGNFIRFIGESAYVAVVTYYLVRINKLSISVYDRVYSFTL--MKNKTNEFIHEVKFFLMRINQHDVGFTFGGLCIITTNFVSTILTIALT------LGLGLPS------LFP------TuGR370/1-359 ------M-----N------Q---INEISVD------ISRISNSSGLLFSFL-VS------LN------AKIGVPIVALL--SI-TSIIGGIFDL------SITNSPT--ESETT--L------SVFNP----IWLKI-YSI------YLGTVLLQFL------VQR------CNYKRFIYNIASLV------PTECP-STKYYLTWQHGTSKL------FITCGLLFELVLS---V----YTTAH-----LTKVT------MKDSSLL-AIALSY----FFHLIAACNWIMV------LQLIIESCIHLKSTLVFINQIVSS------IQA------DNLTIEKV------RSIRSTYSSIIQVTSQLDSFLVYSIFGFYLCILYNCHLHFTNLFI--DNELS------ISNLLCFFGTFSYLLFVTYHIVSINYLVINFSEQIYSLSF---LLFSTEINAEINLFLQRICHFDVGLTFAKLCIITPSFVASFATVLLS------IALAAPS------FRRGQ------TuGR369/1-359 ------M-----N------Q---INEISVD------ISRISNSSGLLFSLL-VS------SN------KRIGVSIVAFC--GM-VSIIGGIFDL------SIRNSPT--ESEAT--L------SLYNP----IWLRI-NCI------YLGATLLLIL------IQR------SNYKLFVYNIASLV------PSECP-STKYYVTWQHGVSKL------FITVCLIYELALT---I----YSSAQ-----STKET------MKNNSIL-LIVSSY----YFNLIAACNLIMV------LQLIIESCIHLKSSLVFINQTVSS------IQA------DDLTIEKV------RSIRSTYSSIIKVTCQLDSFLVFSIFGFYLSVLFNCHLHFTNLFI--DNKLS------IINLLCFISAISYLISVTYHIVSINYLVIYFSEQIYSLSF---LIFSTEINAEINLFLQRICRFDVGLTFAKLCIITPSFVASFATVLLS------IALAAPS------FRRGQ------TuGR367/1-359 ------M-----Y------Q---INEISVD------ISRISNSSGLLFSLL-VS------LN------KRIGVPIVAFC--AI-TSIIGGIFDF------FITNSPT--KSEET--L------SFFNH----VWLRI-YSI------YLGTTLLLFL------IQR------SNYKRFIYNIASLV------PTECP-STKYYVTWQHGAAKL------FITVCLIFELGTS---I----YSSAL-----STKET------MKNKSML-INVLSY----YFNLTAACSWIMV------LQFIIESCIHLKSSLVFINQTVSA------IQS------NNLTIEKV------RSIRSTYSSIIQVTRQLDSFLVYSLFGFYLSVLFNCHLHFTNLFI--DNKLS------TMNLFCFIGTICYLSSVTYHIVSINHLAINFFEQVYSLSL---LLFSTEINAEINLFLQRIGHFDVGLTFAKLCIITPSFVASFATVLLS------IALAAPS------FRLGQ------TuGR368/1-359 ------M-----N------Q---ISEISVD------ISKISNSSGLLFSLL-LN------LN------KKIGVPIVAFC--GI-TSIIGGIFDL------NNTNSPT--ESDET--L------SLFNH----AWLRI-YSI------YLGTTLLQFL------VQR------SNYKRFVYSIASLV------STECP-STKDYVTRQHGAAKL------FITCSLVFELALT---I----YSSAQ-----STKET------MKNSSML-IIVSSY----YFNLTAACNWIMV------LQFIIESCIHLKSSLVFINQTVSS------IQS------DNLTIEKV------RVIRSTYSSIIRITRRLDSFLVYSLFGFYLSVLFNCHLHFTNLFI--NNKLS------TMNLLCFIGTFSYLLFVTYHTVTINYLVIYFFEQIYSLSF---LLFSTEINAEINLFLQRIGHFDVGLTFAKLCIITPSFVASFATVLLS------IALAAPS------FRLGQ------TuGR366/1-361 ------M-----H------Q----IHDKKN------VIKLIVPTGLIAKSL-LM------D------SKIYLIVNLFI--GF-VFVFKGLFVI-YA----AF------NIESSE------E-IL------ISRIED----LFNRI-NDI------LLGVCVIYFR------INR------SKYQRSFSSLSQIL------VTDNT-VADQYVSHHRKIFRY------IYLFAIVYEFLSDL--V----MDYPP-----YISKMI------KHDHTVI-RKTFAI----IVRLLVSYAWILF------VQFIFETCVHLQSAFIVISSNVSR------VNK------RSPLSSHKI------QTFRQMYSQTGEIIANIDSFLVLTVLGLYIYLVATCHFNLVKLFHG-EKTSE-----SIMGLIFFGSHTVYLIFMTFHFVHVNLLSVKCYETVYSLSF---GYYSPEIINEIRLFLERIGRHDVGFTFAKIFVISSNFVSSLATISLT------IALAAPN------LLQ------TuGR315/1-355 ------M------DKMDSNERNTN------VFEICKPTGILAKGL-YS------GRKAIFLFL----GL-ILYIDGLIWA-TG----VW------IPMN------T--M------GAVNV----TIYTV-TQM------ACGTFILLVY------WNR------NKYIECFSHFETSA------QINALCP-TVACYLKKHRFIITT------VISLAFTTYFGTG---C----FYKLQ-----TLDNL------LDSY-EQIFVL----GIRMIGLTGYLAC------LCFFIETCLYIQSCFLQVETQIQI------LSD------SNSALTLDDI------RRVRRLYCIAIETTEKINSLSMPVIAFYFAISIIESHFAFIYTSA--SPN------FYVPLLCCAELSTFSLAIYHMIFINHLATRIHEQVYSFSL---KTDSLIISKEIQIFLTRISLANVGLTFLDIFVITPTCATSLATISLT------ITLATPT------LAKYVKS------TuGR316/1-352 ------MDSNQTNEN------MFEICKPTGILAKGL-YS------GRKAIFLLF----GL-ILYIDGLIWA-TG----LW------IPMK------I--M------GVVTI----TIYTI-IQM------ACGTFILIVY------WNR------NKYIECFNHFESGA------QISSLCP-TVACYLKKHRYIITA------AASLSFVAYFGTG---C----LYMYR-----VSGNS------SNHY-LSIVVL----GTRMIGLTGYFAC------LCFFIETCLYIQSCFLQVETQIQI------LRD------SNNTLTLDDV------RRVRQLYCIAIETTEKINSLSMPVIAFYFVTSIVESHLTFIYTIA--SRN------FYAPLLCFAELCTFSLPIYHMIYINHLATRIYEQVYSFSF---RTDSLIISKEIQIFLTRISLANVGFTFLDIFVITPTCATSLATISLT------IALATPT------LANFIKS------TuGR317/1-355 ------M------NKIDLNERNTN------LFEICKPTGMLAKGL-YS------GRKAIFLFL----WL-ILYIDGLVWA-IE----IW------NPMS------K--M------GTVNI----TIYMI-IQM------ACGTFILLVY------WNR------HKYNDCFNYFESNA------RITSLCP-SVSCYLKKQRFIITT------VISLIYAAYFGSG---C----VFMFE-----VFGNL------SDNC-QQIPVL----GIRLIGLAAYLAC------LCFFIETCLYIQSCFLQVETQIQI------LSD------SNNALGLEDV------RRVRRLYCIAIENTEKFNSLSMHVIAFYFVLSLVESHFTFVYTIA--NPT------GYSLLMCIAELCSFSLAIYHMIYINYLATRIYEQVYSFSF---KTDSLVVSKEIQMFLTRISLANVGLTFLDIFVITPTCATSLTTISLT------FALATPT------LAKYIKS------TuGR321/1-355 ------M------NKIDLNETNPN------LFEICKPTGILAKGL-YS------GRKAIFLFL----GL-ILYIDGLVFA-FE----LW------IPIN------T--M------GAVNN----SFFMV-IQM------ACGTFILLVY------WNR------HKYIECFNYFESNA------RINTLCP-SVSCYMKKHRFIITI------VISLIFAAYFGCG---C----VFMGE-----IYGNL------SDNY-QKIPIL----GIRLIGLAGYLVC------LCFFIETCLYIQSCFLQVETQIQI------LSD------SNSALTLDDV------RRVRRLYCIAIETTEKINSLSMPVIAFYFVISIVESHFAFVYTIA--NPT------GYALLMCIAQVCSLSLGIFHMIYINHLALIIYEQVYSFSF---KTGSLIVSKEVQIFLTRISRANVGLTFLDIFVITPTCATSLATISLT------FALATPT------LANYIKS------TuGR320/1-355 ------M------NKIDSNETNTD------LFAICKPTGLLAKGL-YS------GRKVIFLFL----GL-ILYIDGLLFA-ME----LW------ISMN------T--L------GAVNN----IIYMI-TQM------ACGTFILLVY------WNR------YKYIECFNHFKRNA------GINTLCP-SVVCYLKKHRFIITA------VILLVFAIYFGSG---C----ISIGE-----FYVSL------SDNY-QQMVFL----GIRLIGLAAYLAC------LCFFIETCLYIQSCFLQVETQIQI------LSD------SNNALTLDEI------RLVRRLYCIAIENTEKINSLSMPVIAFYFVISIVESHFAFVYTIA--NPT------GYALLMCIAELCTFSLAIYNMIFINHLAIRIYEQVYSFSF---KTDSLIISKEIQIFLTRISLANVGFTFLDIFVITPTCATSLATISLT------FALATPT------LANYIKS------TuGR319/1-349 ------M------DKMDS------QFAICKPTGIFAKGL-YS------GRTAIFLFL----GL-LLYIDGLIWA-IE----IW------NPMS------T--M------GAVNT----FIYMI-TQM------ACGTFILLVY------WNR------NEYIECFNYFESNA------QIPSLCP-SVACYLKKHRFIITT------VISLVFATYCGTT---C----LYMHQ-----IFGNT------SDVY-QQISIS----GFRMITLACYFAY------LFFFIETCLYIQSCFLQVETQIQR------LSN------SESALTLDDV------RRVRRLYCIAIENTEKINSLSMPVIAFYFVISIVESHFAFVYAIA--NPT------GYTLLSCVAELCSFSLTVYYMIYTNHLATRIYEQVYSFSF---RTDSMIVSKEIQIFLTRIALANVGFTFLDIFVITPTCATSLATISLT------IALATPT------LASYVKA------TuGR318/1-352 ------MELNQTNTD------LFAICKPTGILAKGL-YS------GREAIFLFL----GL-ILYIDGVLFA-ME----LW------NPKN------T--E------GAVNI----AIYMI-TQM------ACGTFILLVY------WNR------NKYIECFNHFEINA------QITSLCP-SAACYLKKNRFIATT------VISLIFATYFGTT---C----FYMRQ-----IFGNS------PDVY-QQISIF----GFRMITLACYFAC------LCFFIETCLYIQSCFLQVETQIQI------ISD------SNNALTLDEI------RRVRRLYCIAIENTEKINSLSMPVIAFYFVISIVESHFAFLCTIA--NPT------VFSIAVCIAELSTFALVIYHMIYINHLATRIYEQVYSFSF---RTDSMIVSKEIQMFLTRIALANVGLTFLDIFVITPSCATSLATISLT------IALATPT------LASLVKS------TuGR322/1-355 ------M------NKIDSNETNTN------LFEICKPTGILAKGL-YS------GRKAIFLFL----WL-ILYIDGLIWT-MG----LW------NPKN------T--A------GTVNI----AIYMI-TQM------ACGTFILLVY------WNR------NKYIECFNHFESSA------KINTLCP-SVARYLKKNRFIITI------VLSLAFAAYFGAN---C----MHLHA-----ILGNE------SNVY-KRISIF----GFRLIGLTGYFAC------ICFFIETCLYIQSCFLQVETQIQI------LSD------SNNALRLDDI------RQVRRFYCIAIETTEKINSLSMPFIAFYFMLSFVESHMAFIYSIA--NPT------GYNITICITELCTFSLAIYHMIYINHLATRIYEQVYSFSF---KTDSLVVSKEIQMFLNRIALANVGLTFLDIFVITPTCSTSLAMISLT------IALATPT------LASYIKS------TuGR323/1-355 ------MESNETNTD------LFAICKPTGILAKGL-YF------ERKVIFLFL----GL-ILYIDGLIWA-IA----IW------NPRN------T--M------GAPTN----AIYMI-TQM------TCGTLILLVY------WKR------NKYIECFNHFERSA------QINTLCP-TVACYLKKNRFITTI------IISLAFAAYFGTN---C----VDLHT-----ILGNQ------TRASDVY-KRIFIF----GIRIIALTGYFAC------LCFFIETCLYIQSYFLQVETQIQI------LSI------SESAITLPEI------RKIRRLYCIAIENTEKINSLSMPYIAFYFVLSLVESHFAFIYTIA--NPT------LYVMLICIAELSTFSLVIYHMIYINYLATRIYEQVYSFSF---KTESLVVSKEIQMFLTRIALANVGLTFLDIFVITPTCSTSLATISLT------IALAAPT------LASYIKS------TuGR324/1-351 ------M------IEMASSETEPN------LFALCKPTGILAKAL-YS------GRKVVFLCL----VI-SIAINFLTWI-LQ----FW------LATN------I--T------VKIYS----AIYSI-YRI------SYVTFILLLY------LNR------KKYIDLFNHFERNA------EISSLCP-SLVRYLEKNRLSMKI------QMVLSYSCFFVLR---T----MYLAE-----NFNSL------EEIF-LNTVHF----IIKSQGLLSCFIF------LRFFAETCLYIQCCFMQVEHQIDI------FRS------STDRFSVNNV------RQIRHLYCLAVEITEKFDYLLLPVTCFNFAFSLIEGHFAFANAIK--YHN------LTALLTCIGEFSILLLIVLQMISINHRATRIYEKVYSFSF---RTDSLNASKEVQLLLVRIAHADVGLTFLGIFVITPTCVTSLATISLT------IALAAPT------ILY------TuGR325/1-354 ------MI------ENESSSETESN------LFALCKPTGILAKAL-YS------GRKVVFLCM----EL-FLLTAFLSWN-CE----FW------FSPS------T--E------GKIYC----SIYII-YQL------IHGIFIFLLY------RNR------NKYIDCFNYFESNV------KIDELCP-SLVNYLKKHRLVKMI------TMLMSFACYFSVA---V----IVMVR-----HFSSN------NDYLQC-IDIFTF----VFKMIGVSCALVF------RSFFVETCLYIQSCFIQVEHQIS------STKRLSIDSI------RQMRRMYCTAIETTEMINSLFIPVTGFYFTVSIVESHFSFVNAIV--NPS------LAVMFIFIGESLSFSLTIYHIIYINHLATRINKPVYLLSF---KTDLLNVSKELQILMTRITHADVGLTFLGIFVITPTCVTSLATISLT------IALATPT------LKTYLIA------TuGR328/1-342 ------M------ESPLN------LFAACKPTGIIAKAL-YS------GRKAVFMSC----TL-VFIFCSVVWA-LQ----LS------KLKE------T--W------RQIYA----IVFCF-HNI------NRAIIVYSVY------WNR------DNYIDCFNHFEFNA------NINTISP-SLIKYLAKNRLIIST------LLLSAFVCYSIAV---I----MALIEFH------PQIWHF----IIKMSAITCYYFY------LNFYVESCLYIQSCFMQVEHQIDL------VNH------SNSTLSLAKV------RQVRRLYCIAIETTEKLNSLLLPATATYFVLSLIVNHYVFSNVIS--FPS------LRVTLMFIAEFTAFFVVTYHIIYVNHLAVRIYEKVYSFSF---KTDAVNVSKEIQLLLTRIARTDVGLTWLNIFVITPTCVTSLATISLT------ITLAVPT------LIKLIRF------TuGR329/1-350 ------MI------KMYTPNETTHN------LFAMCKPNGMLAKAL-YS------GRKVVFLSC----TL-LLAVASITWT-IY----LW------IPIE------A--W------RKFYA----MIYSS-YLM------IFGAIVSSVY------SNR------DKYMDCFAYFEVNA------NINIISP-SLVKYLQKNRFIISI------LLSVGFFCYTVAG---I----VAFVQ-----FGG------DSIWYL----IIRTSSLACYYLY------LNFYVESCLYVQCCFIQVEHQIDA------VNN------SNSLLSLAKV------RQVRRCYCIAIKTTEKLNSLLLPATVTFFVLSLIDCHYVFTNVLA--FPS------LVIILMFIAAFTNFFVVTYYIIYINHLAVNVYEKVYSFSF---KTESLNVSKEIQLLLTRIARADVGLTWLGIFVITPTCVTSLATITLT------VALAVPT------LIKFIGF------TuGR326/1-355 ------M------S--LSSETELN------FFAICKPTGIFAKAL-YS------DNKLVFGSI----AV-LQLVNGLISV-VQ----LW------SLAD------T--V------AKVNF----SICAA-TAS------NCGVCTIVIW------LNR------NKFVDIFNHFERNV------NMNSLCS-SVAPYLKKHRLLIKI------HTLVCFALFFATT---F----YNPAL-----KSNSK------LILC-KFIVIS----SIKTMGLYTYYTF------LSFSIETFLYIQCCFLHVEHKIHE------LNW------SNSEPNIVNI------RRVRCAYCIAIENTRMLNSLLFFLFGAYFVLSFVSTHCALVALIA--DPA------FLTAVITIGNTITFSLVIYHMIYINHLGTRIYEQVYTFSF---KTYSLEVSKEIQLLLTRIARADVGLTFLDIFVITPTCVTSLATISLT------IALATPA------FTEFIILMF------TuGR327/1-354 ------M------S--ISSETGLS------PFTICKPTGLFAKAI-YS------GRNFVYWSI----AV-LQLIDGSIWT-IE----ML------MAQR------I--S------SKIIF----SICAI-TAF------TLATFMAVVW------RNL------NKFIDIFYHFERNV------NINLLCS-SLPPYLKMHRLIIKI------HAILCFSCFFPLQ---I----YSTFAI----QFDSS------LIVW-KYIVLF----VIRTMGLFIFYSF------LGFLIQTFLYIQSCFLQVEHEIHT------LNA------SNRELDIVSI------RQIRYVYCIAIENTEMLNSFLFFLIGQQFILSFVATHSSLAALIA--NPN------FIATVITFGNIMTFSLVIYHMIYINHLATRIYEQVYSFSF---KTDSLKVSKEIQLLLTRIARADVGFTFLDIFVITPTCVTSLATISLT------IALATPA------LVKFVRF------TuGR334/1-345 ------M------NTSNEN------GMNRASKAGIITWAL-LT------DRKNVILLI----AF-GLAVDGLSWI-RY----FA------SLPG------K--F------DALSP----VLFGI-QKC------IYSVFIVLLC------VLR------NDYYDQLTQFERKT------K-LQPTH-TTDRYLTKNRFIFKV------YWFLYIGNFVVMG---S----YLFIK-----RLQES------RVNV-NVILFF----GSTAIGFFGSLAF------FRFFIEACLYIHTCFMRVEHSINT------LNN------STSALSIGDI------RKVRRLYCFAVETTEKLNSLFMLITAIYFVFSTIKSHFSLVRVIH--NPS------PIIISICMVEFSYYFLVTYHMIYINHLATRIYQSVYSLTY---KTDSLFANKEVHLFLLRIERADVGFTFLDLFVITPTCVTSLATISLT------IALATPA------LLK------TuGR330/1-342 ------M------NTVNES------NRVSKTGIITWAL-LS------DQKSVVLIV----AF-GFVLDALTCF-ED----LY------FVSG------A--Y------QITRL----VLIAI-RHW------LIAFLLVALC------IRR------KKYSDYITHFERKT------N-IELTP-STVDYLSKNRLIFQI------FTLIHGSVCILLV------YLAWY-----NASFT------FPAY-APVIFI----GLAAIGILCFIAF------LRFFIEACLYIHTCFMRVEHQIDT------LNN------STNALSINDI------RKVRRLYCFAVETTEKLNYLFMPVIAFYFVMSTVKSHFSIVHVIS--DPS------IVTLGTSLLEFTNFILVTYHMIYVNHLSTRIYQSVYSLTY---KTDSLFANKEVHLFLLRIERGDVGFTFLDLFVITPTYVTTLATISLT------IALATPA------LIK------TuGR331/1-353 ------MLKESL------NKM------NTSNEN------ELNRASKAGIITWAL-LT------DRKFVILII----TF-GLALDGSTCF-KD----LY------FVPD------T--Y------QTTRL----VLVSI-RQW------TCAFLLVLFY------VRR------KKYSDLIIHFERKT------K-IELSP-ALVDYLNKNRFIFQI------FTLTHCCACILVV------SVAWY-----NFSFA------LLPY-FPYIFI----GLATIGILCFLVF------LRFFIEACLYIHTCFMRVEHQVNI------LNN------STNALSIDDI------RKVRRLYCIAVETTEKFNCLFMPIIALYFVINIVSSHFSLVYSIV--DPS------YVTLLISFIELANFIIVTYHTIYINHLSTRIYQSVYSLTY---KTDSLFTNKEVNLFLTRIERADVGFTFLDLFVITPTCVTSLATISLT------IALATPS------LVKC------TuGR332/1-344 ------M------DRSNEN------VLNRSSKAGIITWAL-LS------DRKVIILII----AF-ALAFDGLICF-RD----LY------IFSG------T--Y------HIARV----VILAI-RQW------TCAFLLVLLC------VRR------KKYSDLMTHFERKT------N-IELTP-LSVNYLNKNRIIFQI------YTFIHFLFFVWLT------YGVWC-----NAFDM------SLTY-FLVTYF----GAALVGISCYFAF------LRFFIEGCLYIHTCFMRVEHQIET------LNK------STSALSIDDI------RKVRRLYCIAVETTEKFNYLFMPITALYFVISTVKSHYSFVFAIS--APS------LVTLIMSLVEIANFILITYYMVYINHLSTRIYQSVYSLTF---KTDSLFANKEVHIFLARIERADVGFTFLDLFVITPTCVTTLATISLT------IALATPT------LIR------TuGR333/1-344 ------M------DRSNEN------VLNRSSKAGIITWAL-LS------DRKVIILII----AF-ALAFDGLICF-RD----LY------IFSG------T--Y------HITRV----VILAI-RQW------TCAFLLVLIC------VRR------KKYSDLMIHFERKT------N-IELTP-LSVNYLNKNRIIFQI------YTFIHFLFFVWLT------YGVWC-----NAFDM------SLTY-FLVTYF----GAALVGISCYFAF------LRFFIEGCLYIHTCFMRVEHQIET------LNK------STSALSIDDI------RKVRRLYCFAVETTEKFNYLFMPITALYFVISTVKSHYSFVFAIS--APS------LVTLIMSLVEIANFILITYYMVYINHLSTRIYQSVYSLTF---KTDSLFANKEVHIFLARIERADVGFTFLDLFVITPTCVTTLATISLT------IALATPT------LIR------TuGR337/1-346 ------M------NTSNGN------GLNHASKAGIITWAL-LS------ARKIVILLI----AF-GLGLETFNWF-IA----FS------HSTN------K--F------FSGSA----LIFGI-EKI------IYAFFMFSIC------FRR------DGYTDLVMHFESNA------KIHLNHP-SLEAYIKRNRYIFHL------FTFVNFLILFSLA---I----VPLIV-----KLIES------NIST-LDVLIF----GSWHIGFCSLFAL------LRFFVEACLYIHTCFIRVENQIDT------LNN------SSNALSIDDI------RKVRRLYCFAVETTEKFNSLLWPVISTYFVVSIVNSHFAFARAIT--EPS------FALTMICFGEFSVFFLIAYNMIYINHLATRIYQSVYSLTY---KTDSLFAKKEVQLFLTRIERADVGFTFLDLFVITPTCVTSLATISLT------LGLAEPT------LIK------TuGR335/1-338 ------M------NTSNEN------GLNRASKAGIINWAL-GS------DRKIVILLI----AF-GLALDSTNWF-F------F------LTGTL----PILGI-QQI------IYALFMFSLC------FQR------NKYIDLIIHFEYNA------KLPSNDQ-SLDAYMKRNRYFFYL------ITFINFLINAAMN---I----VPFIM-----GLIKL------NMSA-LRAFVF----SSLQISFFCNFAL------FRFFVETCLYIHTCFMRVEKQIDT------LNK------STNGLSIEHI------RKVRRLYCIAVETTEKFNSLLWPVISTYFVFSFVSVHFIFAKAIA--DAS------FVTILVCAGYLSVFILVAYNMVYINHLATRIYQSAYSLSY---KTDLLFAKKEVQLFLTRIERSDVGFTFLDLFVITPTCATTLATISLT------LALAAPF------LIK------TuGR336/1-346 ------M------NASNGN------GMNRASSAGLIIQAL-FS------NWKIVIVLI----GF-GLAMDSGNWF-VN----AS------LATS------K--F------FFGSW----VIFGI-QQA------IFALFMFQLC------FQR------DKYIDHIMHFDCNA------KVQSNQQ-SLDAYMKRNRYIFHS------FTFINCVVNILLV---I----APFID-----KLEKC------NIRT-IDILKF----GSVEIGFCCSFAL------FRFFVETCLYIHTCFMRVEHQIDT------LNK------STNGLSIEHI------RKVRRLYCFAVETTEKFNSLLWPVISTYFVVCIVKSHWALAAAIT--KSS------FYVALIFIAEFSVFILVAYNMIYINHLSTRIYQSVYSLSY---KTDSLFAKKEVHLFLTRIERGDVGFTFLDLFVITPTCVTSLVTIFLT------LALAGPT------LIT------TuGR365/1-354 ------M-----Y------R----IPINNN------ESSSCKPKGLYDSML-RF------E------GKKSNFVHF----LL-ICVIIYNIVA-LL---LPY------ETST------T--F------KKYII----LINCV-TCT------SQLIWLILLR------SKR------CEYIELVNLFERQS------GLSLENP-LVYRHFAKIRNSFLF------YIVTINAIVAFFN---F----RSCII-----IFQQS------DDFVQSL-KASLFN----LMLLLPVLGFQLF------NQFLVESSLYIHGCWLIVNEQIVS------LRN------IDWRMLTSDKV------REIRSMYSIASETTERMDSFLRLPILNFYSYAIISGHIYLAEIIY--NPS------IVSFIILVFRFLIIALIAYNMIYIHYLSNKCFHDIYVLSY---EKHPFQVNNEIQMFLDRIGQSNVGFSFLKISLITSTFVTSLASLTLS------FALSVPT------FFS------TuGR352/1-351 ------M-----N------Q----VVTING------RVSCSKPRGVYATML-RF------D------GKKSNLIHF----LL-IIAAIYTVLA------SGI------QNRT------Q--L------EWYET----CFQRL-TLT------LHGIWLLMVR------FKR------WQYIELIEIFESQT------RCNLDSS-QAHRHFVKIRTTFYY------FCAFIAFSVMFMI---Y----YYPVM-----TFLDS------NDYFQLV-KSLLLK----SLTAITLVSYLSY------LQFIVESCLHIHACWFAVIERIHS------LKK------TDSRSLTSDEI------LEVRSMYSIAAVVTEKMDSFLRLPIFYFCSLYIITYFILLVQFWH--KPN------IVGFLRLAIRFANLFLVIWNMTYIHYLSTQCFHDVYSLSY---EKHSSQVNDEIHLFLDRIAQSNVGFSFLKVSLITPTFITSLASLNLT------FVLALPS------LL------TuGR354/1-358 ------M-----P------Q----ITNLVG------DSSSSKPIGVIAWMM-NL------E------GTKLTFMNL----LL-IFASIYLISF-DF---LAT------KTSN------K--I------ERLFL----IFRHA-NLG------SQILWIVTLR------SQR------WRYIEMIELFENQT------RCNLGNT-RVRRHLTKIRHLVSCY------VIAFLMLSILITV---F----YKPLM-----ILYDS------KDYLRFG-KSLTFG----LFNVLTILVYPLY------IQFLVESCLHIHACWLTVEEHMRL------LKN------NDSRALTIEKI------REVRSMYSIAAVITEKMDSFLRFPIAIFSAFFIIANFIFFVRVWT--EFS------IIGLARYILRFSIFSFVIWNMIYIHYLTHKSFDEVYSLSY---GKHTFQVNNEIHLFLDRIGQSNVGFSFLKISLITPTFVTSLASLTLT------FVLSLPS------LIEEII------TuGR357/1-357 ------M-----Y------R----ITTLVG------HSSSPKPIGLLAWMM-RL------E------GRKLYFMYL----LL-ISASIYMLYF-DF---LAA------KTSN------G--M------ESFMQ----FFRHA-NLD------SQVLWIVTLR------SKR------WRYIELIDSFENQT------RCNLGNS-RVHRHLTIIRRLFSC------LFAMTFLIILIFI---L----HKSIQ-----ILHES------KDFVYFG-RSLVLG----LFSVLAICTYPLY------LQFLVESCLHIHACWFTVEEHIRF------LKN------IDSRALTIEEI------REVRSMYSIAAVITEKMDSFHKYPIASFFAFYIISSFIFFVQVWN--EFS------LIGFIRFVLRISILLFVTWNMIYIHHLSYKSFDEVYSLSY---GKNPFHVNNEIHLFLDRIGQSNVGFSFLKISLITPTFVTSLASATLT------FVLSLPS------LIEESI------TuGR355/1-360 ------M-----P------R--ICITDLNG------HSTSSRPIGVFAWMM-QL------E------DKKLRLIHL----LL-ISAAIYLIYT-DI---MEA------NTSS------K--L------QKIHL----IFRYG-NLI------SKILWIVTLR------SKR------WQYTELVDLFENQT------RCILGNE-RVYRHSTKVRRIFVPL------CIMFVVQTIFISV---F----YRPIM-----ILYGT------NDYFHFG-KSLTFG----LLRAVFICIYPLY------TQLIIECCLHIHACWLTVDKQICL------LKN------IDRRALTIDKI------REVRSMYSIAAVITEKMDSFLRFPIAIFFGFYIMANFIFFVQFWT--ELS------LNKLIRFVWRCTVLALVISNMIYIHYLSHKSFDGVYALSY---GKHPLQVNNEIHLFLDRIGQSNVGFSFLKISLITPTFVTSLASATLT------FVLSLPS------LIEESI------TuGR356/1-352 ------M------DG------HFSSSKPIGVFTWMM-RL------E------GKKLTFMHL----LL-ISASIYLMYC-DT---STA------ETSN------V--F------EKFHL----IFRHA-NLI------SKILWIVTLR------SKR------WQYIDLIDLFENQT------RCNLGNA-RVYRHFTKIRRLYSCL------FIMYIVQCILMAV---F----DSFIT-----IIHDP------NDYVHFW-KILTFG----LIKAVSLVVHPLY------FQFLVESCLHIHACWLTVEEHIRS------LKN------IDSRALTIEKI------REVRSMYSIAAVITEKMDSFLRFPIAIFFAFLTMANFIFFVQFWN--EFS------IDKLIHFVWRFNYLLFVIWNMIYIHHLSYKSFDEVYSLSY---GKHSFQVNNDVHLFLDRIEQSNVGFSFLKISLITPTFATSLASTTLT------FVLSLPS------LVEGSI------TuGR361/1-353 ------M-----Y------R----ITTFDG------RSSCSKPIGLLTSML-RL------E------GNKSTFAHA----FS-ICVVIYIIYS-DI---SRL------RTST------K--L------EMCFI----FSNSL-SLV------AMLLWFLRLR------SKK------VEYIELIDTFENQT------RFNLDNS-QVYQHFTSIRKCFSF------MVIIILLLYTFAN---I----YTPIM-----IFRKS------NDYVQLG-QSLLLG----LLSSICILCFQIY------NQFLVESCLHIHACWFIVNEQIRL------LNS------TDSRLLSINQV------REVRSMYSIAAVITEKMDSFLRIPIFNFFSFFILSSISVIAQVCY--EPT------LFGCVSLLWRLLKLTLITYNMIYAHYLSHKCFDDVYSLSH---KTRSITSNNEVQLFLDRISQSDIGFSFLKISLITPTFVTSWTSTTLT------IVLSLPS------LL------TuGR358/1-355 ------M-----F------Q----ITTLDG------GSSYSKPIGLLASML-RF------E------GRKSKLTYL----FI-ICIFIYVILR-EFIT-LSF------LTNN------K--L------EICHQ----CINLI-SLS------TLLFWFLRLR------SKR------GQYIELIGIFENQT------RYNLDNS-QVYNHFTSLRKIFWF------CFVSVVFFSEFAN---I----YAAIM-----TIRKL------SDYVQLG-QKLLLC----LIDVLGISCFQLK------HQFLVESCLHIHACWLTVNEHVRS------LNN------IESRLLNIYKV------REVRSMYSIAAVITEQMDSFIRIPLFNFFSYFIFSSFNIIAQVWS--MPT------LFGFIQISLRLMNLIFITYNTLYVHYLSNKCFDDVYSLSY---KVRSIPLNNEVQIFLDRISQSDIGFSFLKIALITPTFVTSWTSTTLT------FVLSLPS------LL------TuGR359/1-353 ------M-----Y------R----ITTLDG------RSSCSKPIGLLASML-QF------E------GRKSKLTHF----VF-NCVLIYINLH-DI---WLF------NTKT------K--L------EMCFE----TVYLI-SLN------VLLFWSLRLN------SNK------GRYIELIGTFEDQT------RCNLDNA-AVYHHFASIRNIFRI------SLVSAMIFFTFAI---I----YNTIM-----TFRKS------DDYVQLG-EHLLLG----LADLICILCFQFY------NQFLVESCLHIHACWLTVNEHVRS------LDN------IESRVLNIYKV------RQVRSMYSIAAVITEKMDSFLRIPLFNFYSYFITSSFDLMAQVWS--LPT------VFGFIGLLIRVFTMTLIIYSTIHIHYLSNKCFDDVYSLSY---KVRSTALDNEVQLFLDRISQSVVGFSFLKISLITPTFVTAWSSTMLA------FVLSLPS------LF------TuGR360/1-354 M------M-----F------R----ITTLDG------RSSCSKPIGLLASML-RF------E------GRKSEFTSW----FF-IFSLIYVILN-NI---WLL------RTKT------V--L------ETCFQ----CLYLI-NLN------VILFWYLKLR------STK------KQYSQLIYRFENQT------HCNLDNS-ESTRRFTSIRNIFSF------YFVFVMLFGAFCV---A----YDPIM-----TFKKS------NDYVQLG-QNLLLS----LLNLLCLLNPQLY------NQFLVESCLHIHACWFTVNEYIRL------LNN------IDSRLLTIDKV------RKVRSMYSIAADVTEKMNSFLRMPIFVFFNYLIISSFENIVQVWT--VPT------VFGIIHILLDLLILTLITYNTIYIHYLSNECFHDVYSLSY---KMRSVALNNEVQLFLYRILRSDVGFSFLKISLITPTFVTSLTSALLT------FVLSLPS------LV------TuGR363/1-354 ------M-----P------P----IIVIED------RYSCTKPMGLFASML-RC------E------GKKSAFTHL----VI-ILCTACYLTI-NI---FSS------KKNS------T--F------EVFNA----YFRST-GAT------LHIIWLLILF------SKR----YQLKYVSLIDLFKAKT------RCNLDSC-EIRRHLVVNRKIATF------VYLIIPFLLPIHN---L----CYSIL-----ISLQT------SHYDQLM-SKLVFG----VLEILTYLSFQLY------NQFLFESCLHIQACWLTVEDHIRS------LEN------IERLTITKL------RKCRSMYSIAAATTQKMDSFLQFPLFNFYSCLFTAFQLNLVINCH--EPT------TVGIIRISIQFLHMAFTTFNMVYINYLSNQCFDHVHSLSY---KTRSLPINNEVQLFIDRIEHSKVGFSFLKISLITPTFVTSMASLTLT------IALSAPT------LFF------TuGR364/1-354 ------M-----P------R----MLPIEN------GSSYAKPIGLFASMV-RF------E------GKKSAFTNF----FL-ILLAICVIFV-NI---FAK------EAIT------K--F------TTCEK----IFRCT-NLV------LYVIWLLRIR------SKR------MKYNAIINLFEAQT------RCNLDRP-NVRKHLSKSRNIFLF------VVTFIALWPPLCD---L----CHSIM-----SFQQT------GDYISLL-KNLSSC----LLYLLCHSSFQLY------HQFLVESCLNIQACWLTVLDCIRL------LDR------IDGRTLTLTEI------RECRSMFVIAAVTTHKMDSFLRFPIFSYYSFLFILFNVHFVNMLR--EPT------VENLIMVTTQSLHLVFVTFNIIYINYLSNKCFDVVYSLAY---KTRSLPVHNEVLLFIDRIEHSKVGFSFLKISLITPTFVTSMASLTLT------IALSAPT------LFE------TuGR338/1-349 ------M-----S------Q----VHPELQ------SDNIHQPSGLFAKAL-RT------NNKTKWLFL----LL-NFAVTVLHTM-Q-----AF------NMHER------FAS----LWHIY-YAT------SYLAICVYLI------FKR------KTYNEFISYFEREI------RAY--ND-SIRKYIAKNRTLITI------GYPFILTLYIIYG---A----YDSIV-----IYQQS------QSFYRLI-IRVIWN----IFKTIIYLNHYII------IQFITECCLHTQVYFKIVEDQVKS------LKM------SNSSLEFEEM------QQIRQLYDVAIGKTRKLDSLLSWVLPVYYFTCIGSFQWNLIFIIY--EYK------PIHLMLMVRELFALILLTFHIANINQLANEAFNQVYSLSY---KVESVEMQNEMRFFFTRIRRGDVGLTILKIVLITPAFVTSFGTLLLT------IALAIPT------IFKKNLT------TuGR339/1-353 ------M-----S------Q----VHPELQ------SDNNHQPSGLFAKAL-KT------NNKTIWLFL----LI-NFTVTVLHTI-Q-----AF------NIHGR------FES----LWHIY-YAT------SYLAICVSLI------FNR------KSYDEFISYFEREI------GAYMSND-YIRKYIAKNRTLITI------GYPYILTIYIIYG---A----YNTIV-----IYQQS------QSYYRLI-IQVFWN----LFRTIIYLNHYVI------IQFITECCLHAQVCFKIVEDQVES------LKM------SDSSLNFEEM------QKIRQLYDVAIGKTRKLDSLLFWVLPVYYFTCIGTFQLNLIFIIY--EYK------PINLMLMVREVFALILLTFHIANINRLANEAFNQVYSLSY---KVESIEMQNEMRFFFTRIRRGNVGLTILKIVLITPAFVTSFGTLLLT------IALSIPT------ISREIEFKA------TuGR340/1-352 ------M-----S------Q----VHPEVQ------YDEYHQPSGLFAKAL-KT------NNKKILSLL----LL-SFTAVCCETL-Q-----HF------KILGS------LFV----LWYFF-YAT------SYLVICVYLI------FKR------KSFKEFINYFAREI------ATYMSNDTSIRKFITKYRTLTTL------GYPFIFTLYSINA---T----FDVIK-----MDQQS------QSNYQIA-IKIFSH----ILRSIIYLNRYAI------IQFIIECCLHVQVCFKMVEDQIES------LKM------SDSSLNFEEM------QQIRQLYDVAIEKSRKLDSLLFWIFPVYYFTCIGSFQLNLVIIIY--GFN------HLYLIFMVREVFSLILLTFHIANINRLANAAFNQVYSRSY---KVESIEMQNEMRFFFTRIRRGDVGLNILKIVLITPAFVTSFGTLLLT------IALAIPT------IFKKNLT------TuGR341/1-349 ------M-----S------Q----VHPETQ------VDEYHKPSGLIAKAL-RT------NNKTILFLL----LL-SFIEVCIETM-L-----VF------KIHGS------FFV----SWYFF-YAT------SYLVICVYLI------FKR------KSFKEFINYFDREI------GAYLPND-SIRKFIAKNRTLVTI------GYPFIFTLYSIKG---T----FDVIE-----IDQRS------QSNYQLA-VKICLN----LYRSIIYLNRYAI------IQFIIECCLHVQVCFKMVEDQIES------LKM------SDSSLNFEEI------QQIRQLYDKAIGKTRKLDSLLFCVLPVYYLTCIGSFQLNLVLVIY--EFN------HLYLMLMVREVFSLILLTFHIANINRLANEAFNQVYSLSY---KVESIEMQNEMRFFFTRIKRGDVGLTILKIVLLTPTFVTSFGTLLLT------IALAIPT------ILKKN------TuGR342/1-349 ------M-----S------Q----VHPETT------SDDYHQPSGLFAKAL-TT------KNKTILFLL----LL-SFTMNSFDAI-R-----DF------KMAKD------FVS----AWRIL-YLT------SYLAICIYLI------FKR------KSYNEFINFFDREI------GAYMSNE-SIRKYISKNRLLTSM------GYTLILTVYLTYG---V----LDIIQ-----VYQQS------QSYYRLI-IQVFWN----LFRSIIYLNRYVI------IQFIIECCLHTQICFKMVEDQIES------LKM------SDSSLDFGEM------QKIRQLYDVAIGKTRKLDSLLFWVLPVYYFTCIGSFQLDLVFIIY--EFN------HLYTMFMVRELVTLVFLTFHIANINRLANEAFNQVYSLSY---KVESIEMQNELRFFFTRIRRGDVGLTILKIVLITPAFVTSFGTLSLT------IALAIPT------IFKQS------TuGR343/1-349 ------M-----S------Q----VHPETQ------SDDYHKPSGLFAKAL-RT------NNKTILFLL----LL-SLTMNSFDTI-R-----DF------KIAKD------FVS----AWRIL-YLT------SYLAICIYLI------FKR------KSYNKFINYFDREI------GAYMSNE-SIRKYIAKNRLLTSI------GYTLILTGYLSYG---V----HDIIQ-----VYQES------QSYYQLA-MKSLWN----LFRSIIYLNRYVI------IQFIIECCLHTQICFKMVEDQIES------LKM------SDSSLDFEEM------QRIRQLYDVAIGKTRKLDSLLFWVLPAYYFTCIGSFQLNLVFIIY--EFN------HLYLMFMVREVVTLILLTFHIANINRLANEAFNQVYSLSY---KVESIEMQNELRFFFTRIRRGDVGLTILKIVLITPAFVTSFGTLLLT------IALAIPT------IFKKS------TuGR344/1-348 ------M-----S------Q----VHPEIQ------SDDYHQPSGLFAKVL-KT------KNKTIL-LL----LL-SFIVGSFERI-Q-----SF------EIKKG------YLS----AWRLL-YVN------SYLAICIYFI------FKR------KLFYEFINYFDREI------GTYMSND-SIRKFICKNRLLFSI------GYPFVFTLHIAYS---V----NDIIQ-----VYQQS------QSYYELA-IRLIWN----LFRSIIYLNRYVI------IQFIIECCLHTQICFKMVEDQIES------LKM------SDSSLNFEEM------QRIRQLYDAAIGKTRKLDSLLFWILPVYYFFCIGSFQLNLIFIIY--EYQ------PLHLMFMVREVVALILVTFHIANINRLANAAFNQVYSLSY---KVESIEMQNEIRFFFTRIKRGDVGLTILKIVLITPTFVTSFGTLLLT------IALAIPT------IFKKS------TuGR345/1-348 ------M-----S------Q----VHPEIQ------SDDYHQPSGLFAKVL-KT------KNKTIL-LL----LL-SFIVGSFERI-Q-----SF------EIKKG------YLS----AWRLL-YVN------SYLAICIYFI------FKR------KLFYEFINYFDREI------GTYMSND-SIRKFIGKNRLLFSI------GYPFVFTLHIAYS---V----NDIIQ-----VYQQS------QSYYGLA-MRLIWN----LFRSIIYLNRYLI------IQFIIECCLHTQICFKMVEDQIES------IKI------SDSSLDFEEM------QRIRRLYDVAIGKTRKLDSFLFWVLPVYYFICIGSFQLNLIFIIY--EYQ------PLHLMLMVREMVSLILVTFHIANINRLANEAFNQVYSLSY---KVESVEMQNEMRFFFTRIKRGDVGLTILKIVLITPGFVTSFGTLLLT------IALAIPT------NFKKS------TuGR346/1-345 ------M-----S------Q----VDPEIK------SDEYHQPSGLFAKAL-KT------KNKTILLLL----LL-SFVMNSFEGI-Q-----NF------EIKKN------YVS----AWRIL-YVN------SYLAISIYLI------FKR------KSFFEFVNYFDREI------GVYMSND-SIPKYIGKNRFFISI------GYPFIFILYIIYG---V----HDIIQ-----VYW------QSYYGLA-MRLLWN----LFRSIIYLNRYVI------IQFIIECCLHTQICFKMVEDQIAS------LKM------SDFSLNFGEM------QKIRKLYDVAIEKTRKLDSLLFWVLPVYYFTCIGSFQMNLVFIIY--EYN------PVSLMLMMREVVTLVLLTFHIANINQLANEAFNQVYSLSY---KVESVEMQNELRFFFTRINRGDVGLTILKIVLITPAFVTSFGTLSLT------IALAIPT------IFK------TuGR347/1-345 ------M-----S------Q----VDPEIK------SDEYHQPSGLFAKAL-KT------KNKTILLLL----LL-SFVMNSFEGI-Q-----NF------EIKKN------YVS----AWRIL-YVN------SYLAISIYLI------FKR------KSFFEFVNYFDKEI------GVYMSND-SIRKFIGKNRFFISI------GYPFIFILYIIYG---V----HDIIQ-----VYW------QSYYGLA-MRLLWN----LFRSIIYLNRYVI------IQFIIECCLHTQICFKMVEDQIAS------LKM------SDSSLNFGEM------QKIRKLYDVAIEKTRKLDSLLFWVLPVYYFTCIGSFQMNLVFIIY--EYN------PVSLMLMMREVVTLVLVTFHIANINQLANEAFNQVYSLSY---KVESVEMQNELRFFFTRINRGDVGLTILKIVLITPAFVTSFGTLSLT------IALAIPT------IFK------TuGR348/1-349 ------M-----S------Q----VHPEIQ------SDEYHQPSGLFAKAL-KT------KNKTILLVF----LL-SFTIGSFERI-Q-----SF------ENKRD------FVS----AWRIL-YVI------SYLTISINLI------FKR------KSFFEFVNYFDREI------GTYMSND-SIRKFISKNRLLISI------GYPFILTLHIAFS---V----SAIIQ-----NVQPS------QSNYQLA-MEIFSH----IVQSIIYLNRFVI------IQFIVECCLHTQICFKMVEDQIES------LKM------SDSSLDFEEM------QQIRQLYDIAIGKTRKLDSLLFWVLPVYYFTCIGSFQLHLVFMIY--EYK------PISLILMVRELFTLILVTFHIANINRLANETFNQVYSLSY---KVESIEMQNELRFFFTRIRRGDVGLTILKIVLITPGFVTSFGTLLLT------IALAIPT------IFKKS------TuGR349/1-355 ------M-----S------Q----IHPETQ------SDDYHRPSGLLSRSL-QT------LNKTKLFLI----QL-SFIVSYIDKV-Q-----IY------TVKTTS------H-SA------IKLLS----SWLNF-NGI------INCSICLYFI------LKR------KSFSKFVDYFDKEI------ANYSKND-HIRKFIAKNRIITNM------YFPFFFILYFTYA---I----YDVYI-----FYRES------EPYDKLA-FRVFRN----LFRSTIHLNHLVL------MQFIVESCLHVQICFKMVLDQLEC------LKR------ADGLLKIEKL------QPIRQLYDIAAEKTRKLDSLLFMILCAYYCGCLQVYEINFAGLIN--NYS------YIRLLVIVRETLILIYITFHVANINRLANGAFNKVYSISY---KAHSLAIITEIRYFLIRIGRNDVGLTLLKIVLITPSFVTSILTLSLT------IALSIPS------IFTKT------TuGR350/1-355 ------M-----S------Q----IHLETQ------SDDYHRPSGLLSRSL-QT------FNKTKLLLL----QL-SFFATQYNSN-V-----VN------YKPTTF------K-IL------DSVFL----SWLSF-NSI------LYFIMCLYLI------FKR------KSYTKFVDYFNDGI------GNYAKND-HIRKFIAKNRIVTKI------HCSFIFIVYLIYG---I----LNISK-----SYNEP------QPYGQLA-FKLFMD----AVRAIVYMNRFVL------IEFIVESCLHVQICFKMVSDQIES------LIE------TDGLLRFEEL------QKVRQLYDIAVKKTRKLDSLLFMVLPAYYLACLVSYELHFAALIN--KYD------HIHLIIIVREALTLIFVILYVANINRLANKQFNRVYSLSY---KAHSLEIMNEIRYFLTRIRRNDVGLTLLKIVLITPAFVTSIATISLT------IALSIPT------IFRKN------TuGR351/1-361 ------MC------E----SGLSIE------FMVDHKPNGILAHSL-QT------ASKTRLILIQV-GTL-LSFLDSMYHY-MH----IK------SVKGD------I------FLFLSF---SWNNL-HKV------FYFFIGFYLI------WKR------SNYNEFINYLDSEI------SIRCQRP-TIKKFIRKNRKFFSM------YLISYTLYLSMFS---L----YLAYH-----DYLKT------KSLYQMA-MTFAIE----LCKALLHMSNLVF------VQFIVESCLYAQVYFKIVHQDINC------LKS------STSHINAEQI------YKVRKFFCGLLEKTRKLDLLFGWVLLGFYSFCFLKLQLSLAVIIDG------VGRPFRTMLFICESMTLIIVTYHVVYISHLSDKCFDPVYSLSY---KLNSLQAKNEVQLLLDHIGHSNAGLTLLKVVPITPTFVTSIVSLTLT------IVTAFPS------LLELIKPS------TuGR297/1-361 ------M------NNSFDISSIFMVIV-NKKSQ------KSQK------SKKSSYLLLAV--LLLLTASIGSFTM-FN----AYQ--NILPAKT------L------REKNVC--VLQFLIG-MAI------ILAYFSLVFL------CDW------KRCVEFIEIWSQTG------LQHDQ-EIINYIKSERKKYRLI------ITILVVVFAVTVV---L----FNPRY---GQRLHQM------SVY-QLIAVI----SISFSYPALFSLV------FDFPLQFSLIICTVFIRVNQRLEH------LIE------HSESIDGNI------KSIRFMHSVGSQLTLKADQFIRYFTAVNYFIMISFMLINLYSIIFL-SESLS----DYFAGIGLQFVVISMTAIFTYYAIKINHLASKGFHHAYQLTF---AENCPSSFAETSLLIYRMGRNDIGLTFANLFTITASFVTSLVTLCIT------IILAFPT------IKSQF------TuGR298/1-353 ------M------NNNIDVSSIFMIII-NK------K------GKKVHYVLLAV--ILLLTASIGSIIM-FN----AYV--NILTAKT------L------REKIFC--VLQFLIG-ISI------IIDYFFLVFV------SDW------KRFVEFIQIWTKTG------LQDDE-EIINYIKRERKKYRVI------IFALDILFTTTVS---L----FSPQY---GQRLHQI------SVC-HFATVI----CISFTYSLLFSLV------SDFPLQFALIICTVFIRVNQRLEH------LIE------HPDSVDDNI------RSIRFMHSVGSQLALKADQFVRYFTAANYSIMVSFILINLYSIIFL-SESLN----DYFAGTGVQVVVTSVAAMFTYYAIKINHLASKGFHHAYQLTF---IANSPNHFAETSLLVYRMGRNDIGLTFANLFTITASFVTSLVTLCIT------FILAFPT------IQC------TuGR302/1-363 ------M------CSDKKMTTE------VDEPIEISSIFTVMV-NN------K------NRKFRYFLLMV--ILSLTVAIGSYAM-YK----AYL--GFSAFEG------L------NEKSFF--ILQLLNG-LVI------IFSYFILIFV------CNW------KRFVEFLEVWSQTG------LEHDS-KTIKYIKYQRKKCRL------LILIHVILNVTVS---S----STYRT-----EKQSLE------YIF-ELVPIA----FTSFTYAVLLGLI------TDFSLQILLFICATFLHVNKRLEH------LTK------FPNSTEDNI------GSIRLMHSFGSQMTLKADQFIRHFIACTYSMMITFILIDLYRMIYL-STTPT----DYYISIIIQFVVISMTAVFTYYVVKINAWASKGFHHAYQLSF---TKNNPSHLAETSLLMYRMGRNDIGLTFANLFTITASFVTSLATLCVT------FILAFPT------IKSQF------TuGR299/1-372 ------ML------IVSSDNKQVPE------MNKVIEISSIFTVIV-DK------K------SRKTRYFLLAI--ALFLATLIGSFIM-YT----AYK--NFLTSET------L------AGKNLC--ILQFLNG-FSV------INVYFCLIFV------CDW------KRFVEFKEIWSQTG------LQNDP-ETISSIKSQVRNYRRF------ICALNAVFTFTAT---L----SIYQS---DLSFKPK------DVF-QSIFVT----CVSFIYSFLFGLI------TDFPIQMVLFICSVFVRVNQRLAY------LIK------HPDSAEDNM------KSIRLLHCIGSQLTRAADQFIRYFLATSYALKVSFILINLYRIIYL-SETLS----DYFISLSLLIAVSSMTAFVTYNAVKVNNLASKGFHDTYRLSF---TKNCPNYFAEASLLMYRMGRNDIGLTFANLFTITASFVTSLTTLCIT------LILAFPT------IQSQVNKQC------TuGR300/1-370 ------ML------IVSSDNKQVPE------MNKVIEISSIFTVIV-DK------K------SRKTRYFLLAI--ALFLATLIGSFIM-YT----AYK--NFLTSET------L------AGKNLC--ILQFLNG-FSV------INVYFCLIFV------CDW------KRFVKFKEIWSQTG------LQNDP-ETISSIKSQVRNYRRS------ACALNAVFTFTAT---L----SMYQS---DLSFKPK------DVF-QSIFLT----CVSFIYSSLFTLI------TDFQIQMVFFICSVFVRVNQRLAY------LIK------HPDSTEDNM------KSIRLLHCIGSQLTRKADQFIRYFLATSYTLQVSFILINLYRSIYL-SETLG----DYFISVSSLTAVSSITAFVTYNAVKVNNLASKGFHHTYRLSF---TKNCPNHFAEASLLMYRMGRNDIGLTFANLFTITASFVTSLATLCIT------FILAFPT------LQSQPNK------TuGR301/1-370 ------ML------IISSDNKPVPE------MDKGIEISSIFTVIV-DK------K------NRRMRYFLLAI--FLSLVVSIGSFIM-YV----AYK--NFLTCET------L------AEKNLC--ILQFLNG-FSV------INVYFFLLFV------CDW------KRFVEFKEIWSQTG------LQNDP-ETINNIKSQLRKYRRF------ICVINGVFTVPAT---L----SIYQS---DLSFKPK------DAY-EFILIS----CLSLIYSALIGLV------TDFPIQLALFICSVFTRVNQRLAY------LIE------HPDSTEDNM------RSIRLLHSIGSQLTLKADQFIRYFLATSFSLYVLFILINLYRIIYL-SYTLT----DYFISMSILIAVMSMTAFITYNAVKINYLASKGFHHTYQLSF---TKNSSNHIAEASLLMYRMGRNDIGLTFANLFTITASFVTSLATLCIT------FILAFPT------IQSQSNK------TuGR296/1-341 ------M------LTNHL-LLAFK------TITKL------SGISAMIGASL-P---IFHTFGIFHW-YE------T-HF------HEIAFSM------FSD------LVYGFVFVFI------LPWQELVKSITLMGFIDNLETRP------IGLDA------TRKRKHYKY------LFIQLVLHFLGISA--V----VKSQS--STKPLSDSEW------IDVWIN----PRRSLFYRANMLLIFTC---CNCIICYLSTELEFTFKLINWQIAS------FAR------KIDATTQEL------NLMRRSYSMAIRSCQAADQFSRYLIVLRILTLVAFNPIVFI------KQSYVDVFKQFYAFVVYTGAKLVLLIQLVDHLVALNSASHSSLQELHKISM---RNDVD--NQEIKLFLMRMNEKNVGFTFLQLFTIDRQFITSLLTFSLT------IILAIPT------FISLYNE------TuGR294/1-380 ------M-NLP------KTVTKSQSIVT------MYSLLNPNQLYNPPV-HR------H------NQKHRLIPKIS--GV-SSLFLGIYLL-LM----VLVTKPISHENT------D--I------SAVVIAS-----R------DCLGY------IGLAIVMFFG------TNW------SFLDSSNGLTINLN------C--PDHNP-TFNSYVKFHRLVKKL------ILLVTSIYYYLVY------DLFFIALDRRYFIEKSYLS----RYMIHYV-FNLLLG----FLAILAHSGAIYL------FNIIYDGIIILNGSFKCFNQQLID------LHG------KRPSLDQL------GQLRCYYSYLIQSTLKFDQFARYEICRLYINSISAYLFGLLGLFIH-KNEKT----TIISIILIFLFDSLIVIVLTLNSIMLNKNCHQELETLYELSL---PMRSAIYRSEVILFYNRLSKNDVGLTFLNIFTLKPNFVLSIVTLALT------IFLAIPS------FIPLILK------TuGR303/1-426 ------MN------ELVKQSDQQIDYNQVTIETTKLNSKVTPIENVILNSFNEQTGRFNQEHCTSPTVNVLEAKRSFLRL------QTRSI------VNEIDNKWITRIQKKYRKLFMLLG--II-IIAYNTTHNS-LMLF-KVL---PVPNTYP------L------ISGQTST--FVIIFLADGLFC------LIAYLGLIYR------TDFTDFELKWKSIG------ISSQDPFLDRMLKRTAREIAI------CSIVSLLGWLITLL--V----FTWTV-----IQNDWD------QGMVHVT-MEIVHI----FSYIFIPFFAWGK------FHSLYTCSMIIRSVFTMIGKRMLNQ------PETFWNTETL------RFYRQMYSRTIDLTESSNTIWSRYLSFFYPMLNLFAIIIVYYIISG-PLNLF----RYVVLGILDFTAFWAIFFTNRYIVGINVEAASIYNIVYGKSL---FRNNVDYMIEASLFLERIGREDVGYSYEGLFVYSPRLMTSILTLAVT------IIIAFPS------FVSK------TuGR304/1-424 ------MN------EVVKQNDQQIDYNGVT--TEKSNSTVTPIEQVVLNSMNGSITRFNQVHHRSPTVNVLEAKRSFLRL------QTRSI------VKEMQNKWLTRTQEKYRKFLMLLA--II-IIAYNTTHDA-LMMF-RLL---PVPNTYP------L------ISGQMST--IIIIFLADGLFF------LITYLGLIYR------TDYTDFEQKWKSIG------LSSQDPFLDKMLQKTAQEIAI------FSIVAMIGWTVTLS--V----FSWIV-----IQNDWD------NGIVPVT-MITVHI----SSYFFIPLFAWAK------FYSLYTCSMIIRSVFTMIGKRILNH------PDTFWNTETL------RFYRQMYSRTIELTESSDNIWSRYLSIFYPMLNLFAIIIVYYIISG-PVNLF----RYAVLGILDFTAFWSIFFTNRYIIGINVEAASIYNIVYGKSL---IRNNVDYMIEASLFLERIGREDVGYSYEGLFVYSPRLMTSILTLAVT------IIIAFPS------FVSR------TuGR306/1-384 ------MRRIQLTSFDIPEK------ISDSVNLNSLSES------SGKSI------VLLLQSGWLSYVQQNFKPILRAIG--IF-ASVSSVTHTV-LMLA-SVL---PLWDASP------I------IPGNVLI--IMCTLVMDFNIM------GVMYISFIHK------IDFSRFEKKARALG------FDYDNPIMANILKRARRKVTI------IQVVFVFSWFVNTI--V----FSIIF-----YINDSH------KGSTVAT-IEIIHV----LNCVLIPLLPSNK------IFTLFTSAIFIRSVFTLFNQRLMDH------SQWTFTDL------RFYRKMYSQAIDLTKSINQIWQNFLVIFYPAVNGFVLYFIFYTITG-PVSML----RYAILGFLAATFILLFVYTNRFITGVNIEAFAIYDTIYIISL---NNKDVTYTEEANLFLKRIGRQDVGFSYETYMVYSPRLVGSVLTLLST------IMIAFPT------FTRHY------TuGR307/1-389 ------MKRIQLTSFNIPVE------KNNSQN-NSFTERLT------PDSNGKSI------VLLLQSDRLNYIQQNFRTILQAIS--IF-ASIFNLTHTV-LMIA-SIL---PVWDASP------A------IPGDIFI--IVITVAVDFTML------GCVYLSFIHK------INFSKFEKKARALG------FNHDHPMMANILKKARRKVTI------IGLLFVSSWLLNVI--V----FSVIF-----YMNHYS------MGSTVTT-IELFHV----YNFILIPLLPSNK------IFTLFTSAIFIRSVFTLFNRKLINH------STSQWTFADL------RFYRKMYSRAIDLTKSTSQIWQNFLVIFYPVINGFVLLFIFYTISG-PVSII----RYSCLGLLAATICLLFVYTNQFITGVNIEAFSVYDTVYIISL---NNKDVTYTEEANLFLKRIGRQDVGFSYETYMVYSPRLVGSVLTLLST------IMIAFPT------FTRH------TuGR305/1-378 ------M------SSNLIKPFQILGQNK-IP------TTPIKPP------IPDHLRFRILPIFPGRVNLISFLTF--TL-LFASTLGHDI-AMFF-GYL---PRFDFCG------L------LTFSGSS--IITVLGGDIFIN------ALLVIVFLFP------LDYSQYEEAWRLVG------FSLNDPFITDELKRAKKETLI------FAILFLITWLCYLP------GCVYIA-----VIQPHE------AGLIQMA-FETSHQ----VSYPLVGILVFIK------VHTLFTSSSLIRASFILIKKSIKAH------PEVTWSLQSL------RYYRQIYTATIELTSTANNIWSAYLSFMYPAFNIMGLVSLYTMISG-SYDFS----RYFILGSSSLSLFWTSSFMNKYIIGINVEAASVYDVVYQKSL---LDLGEKYMMETMLFLERIGRADVGYRLHGSFVFSPTLMASMVTLGVT------IIIAFPS------FAH------TuGR308/1-412 ------M------KLQLSILKISSLYANRFTIFTHLFHVEKFKMSTISQVIFDQNVDSCTGFAV------KNGGETISI------VDHFQNNRFNLLHGKRRGILIVLA--IC-AFIINGAHDF-LMFK-SVQ---FIPDVSP------L------VVGANQT--IYIFLVGDACLG------FGFCLAFWYK------IDFTEFSLKWSQSH------LITPKFSPLKTLARLNKSLNL------LLIFIMFASISAVAN-I----IYLII-----TQTNRD------EHGFNVT-LAVIHM----ASHFLMPLLFTHQ------LYLLFASTVTVKSLFTQIGKQIKSH------TKSTWSAAKL------SHYRQQYALAIELANEANNIWSQYLAFFYPSINLMAIIFVYYIISG-PINIY----RYFIFAQIAGSIFLLIFYLNHYIIGINTEASSIYDIVYEKTF---YSKNVNYLSEINLFLDRIGRENVGYRFEG-FVYSPGLVASTLTLIVT------IIIAFPS------FV------TuGR528/1-489 ------M-----T------T------NEPKVITPTDHESESL-VDQDNSEI-----NQLNHVSNNDNNGEETSVVISNTEDNTSEDKSLTNNEDKPSDNGSTVS---NDDNQVAVNLE-DTSNAGPEIDLKLTFIGI--LVNQPLLKPIYRL-LT------KRTG------R--LRIQRIVYFMGTFAI--THSFLML-ISVLPSAGLVDSFGSRLDFMKFTLFLNDVTLFTMLNGI------LAR-----EPPLNQLDSIWQTLYSPSADQPTKDNIEIKQ-WVSDRVKSVRKRLYL------LIVLSTVIYFQLL---I----TIALD-----STSSILSPI------TL-VDMVHI----IVDLIGLLIVHLL------VYQFLISTILAQSIFRDINNSFREDKRIQSSSLSN-----HHPSSSPLHSTTLART--DKSEDIILYRRYRYCNTIEFIRTANNHWKHFLALFILFNFVPSVFQLHFVLNK-QLDGQ----QLVELIYRFLINIAATYLIIINVTQVNLLSNQFYDDLYQLTL---KETNDPTRLEALLFLDRVDHGEVGFTLSDSFLITPNFTSILFISLIV------LVFILPT------IA------TuGR310/1-376 ------M------IRYISNNNPINFKIENKN-VQLEKSKIVITNFYLQHV-YK------S------SKLIKFTWNIA--II-IFVVNRLMDR-YF------SYQQ------N--L------IKFDR--TNQIYSINILL------GDLWYFYMLST------HDW--LYNSVDIEKINKLWHSID------LPVNY-YNQNFISSRRSKASKV-----FMLIIGLVFCCDAAT--I------NMERYP-----NYPKCTFI-HNLISI---LINYYATVMTFTIH------SSLLVEMTILISASFNHINRFIGG------LGS------SQQL------TNLHQMHTKTIQLTHRVNSMFTNFIIYLYPASLFRVTTIIYSFMFQ-PISTIAI-NLNLLSVIKFVNPPIFIIFITLSLSAVHQFSYNCSNHLYYLTH---RSLPDDIKYQVATFLYRVDRKDIGFTFWKLALIGPSFSSSMTTLLLI------TIIVLSA------INYLY------TuGR311/1-372 ------M------IQSDRQKFIGTT-----DSKTIPIINFYIDNV-YG------K------TKRVKLLWNFV--LA-ICLIFRVHGS-YK------HFSQ------K-PI------KVVGFLP--IEMINAL------L-SDLSHIYLLCS------HQW--VFRSTNIEPIYNLWSSIG------LPSNK-VNLNYVSSRRKKSLIC-----FMILIGLLFYNETP---I------SLKTRY-----SSALCNLI-HNTISL---FIRYCSVAISCSVH------GPFLIELAIVISAAFNHVNLLISK------LDE------TNLSQL------AEIRRLHSQIIILSRKCNSLFSFFIPFAFPIQLFKIINIFYLLLFD-PISQNNI-NLNTLDIVNSFIGPIYLGFTVFRLMEVYTSSIACSDSLYALSH---RIQSPETQYEIVLFIFRVDKKDIGFKFWRLAIIGPNFFSSLTIIMIP------LIISLPI------LKANPFQYF------TuGR312/1-378 ------M-----ATLKVE-KLRPRVSCQHKIFLTNI--RPQIDDKIKINWFFIKFF-TN------C------SLKSKIIWNTG--LIILTAVPLTIAL-FK---QKF------SFET------N--L------DRILTLN------ASS------EYLFLFYVIIF------HQW--DFRESVVNQINQLWSNID------LPVNR-HLKRRLFKERSICVV------LAAAFIALEFVNK---IT---LGYFR------FDDWISIL-KSVFSL---ASLLAFGILNCFLH------FQFLMEMVILITAAFDHVNYLIEL------QAE------NGPTLNDI------KSIRRLYSDIVQLTDYFAESLKTFVTLVYLKTAYLIVSISYTAFIS-GYTVS----KTFWMALVYSTGPVLVLFLTFRIIRVNISAYSSFDDLYSLTP---YATTKEMKFELLMFIHRVARNDVGLKFCKSTLIGPNFFSTLLTICVA------SFFVGIT------FVIEPN------TuGR313/1-373 ------M-----LNLEVE-TLKPRVSYQHH-----T--RPQIDDKIKINWFLIQFF-TK------C------SLKRKIIWNVS--VFILIVIPIIVAL-FK---QKF------SFES------N--L------DRILTLN------ASS------EYVFLFYVLLF------HQW--TFRESVVDQINQLWSNIN------LPANQ-QLRRRLFKERSMCIC------LTLAFISSTLVNK---IT---SGVYE------FLDWISVL-QSVFCL---VSFIAIGIFYSFLH------VQFLMEMVILLTASFDRVNYLIEL------QVE------NGPTLDEL------KSIRRLYSDIIQLTDYVAESLKTFITLIYLKTAYLIVSISYTMFVS-GYTVS----KTYWMALAYFSGPVLVLFMTFRIIRVNISAFASFDDLYSLTP---YATTKEMKFELLMFIHRVARNDVGLKFCKSTLIGPNFFSTLLTICIA------SFFVGIA------FVLQPN------TuGR314/1-378 ------M-----SNLKVE-KLKPRVSSQHNIFLTST--RTPIDAKVEINWFLIQFF-TN------C------SLKSKILWNST--LITLIVIPVIIAL-SK---QKF------SFET------N--L------DRILTLN------ASS------EYLFLFYITLF------HQW--TFRKSVVDQINQLWSNIN------LTANQ-HLKHRLLRERSTFVI------LALAFISFGLLSK---IT---SEEYQ------FVDWISIL-KSVFSL---ANRLAFGIFYCFLH------LQFLMEMVILITAAFDHVNHLIEL------QVE------NGPTLNEI------KSIRRLYSDIVQLTDYFAESLKIFVTMIYLKTTYLIVSLSYTTFVS-GYTVS----KTYWMALAYFTGPIIILILTFRIIKVNISAYSSFDDLYSLTQ---CATTKEMKFELLMFIHRVARNDVGLKFCKSTLIGPNFFSTLLTICIA------SFFVGIA------LILQSN------TuGR253/1-375 ------MQ---LNVIDGSAKLFTSQRRTPS------RYNLTKLASDNFFLKSLSFK------TLPGSIIIRRI--VIVFTFAGNVFNL-YLRSSMLF------T--L------NDIKFKQ--VFDIFEQ------SIFCLCFIFISSGPFHINL-----DNFYENFDSIWRRII------IAQGT-VCETFILSETKRINR------ELIVMLLLGTTML---L---GFALLG-----IFGKDELW------QASITF----FALAYTLYLNIGY------IYILRLSVGLIKAGFQSIESRLET------CSV------TLANLGHV------RLCRQSHNQIIQLIDLLQTTFKHVFSAFICFFVPQFVFGFYQLAVS-SQTIL----INVVTIGWNSVNFYFVLILAEGLILLNTLPQSYYLALYLTSF---GDISGLVKIEINHYLNYVASKDVGFRLWGNFLVNNELIPKLCAVVFS------YLTAGVS------FLQ------TuGR254/1-404 ------M-----SLSKEF-HLFPESKHSI------VNFKDQQSTLIVQYL-VQNNLVYRN------YQDWPILQLF------NKIFASIGFVVGCIVLLSSTSILVSR-IYMTGSII------N-EIN------NAIFFTC-LTASG------DLATYYDQFF------YNP-----VTFSAKFDEIWKDLM------LSGEN-QVRHDIKQIRRQQRKD------VIIFSLGQFWLIIALGI------FAPEAKVYWVKIAQY-GRRILLFIAAFYYITL------VDHLGTCSAFINSAYNSLSRQTKR------LSR---IRLTMLQDSDRVDQM------IYIRNNYEKIGRLIELVNQTHSIFVGAFYLLVIPKCVTLVYDLIYT-SSSYL------VYHITELFFQALRLLVITRSISMIPAYTTKPRMSILNVSL---STKDPSLIIESELFLQRIYHQSFGITIFGKMLVCPSITGTLITAVVT------YFIGIAS------FNAGSIVSSPTSPDVIQ--IE TuGR255/1-391 ------M------STIRSNGAASLYDYY-IQSNQ------FFSVIE------RSTDYVKVFKFIGMIG--LC-EKIYMTILYT-----GTLI------N-EL----M-GKNDFFDETNNRILFNL-FTTID------QLFIFHDWFT------FDP-----FLFSSAFDEIWKTLP------FSN---ATTHKIESQLTYCKLN------FTILTLSQFILCY------ALLFH-DPLVEQKKV------SNLTYI--SKVFNVLGYGYSLFI------VNHLLITGVFLHSGFVSLSSILDS------LVNYSKTKLCLSKQHLRPKII------CYYRNVYNFLGQLTDLTDRSHRMFIGTFYLTCVPKMVTMVYDIVFT-GAEFK------IFHIAEACANVIRLIVITNSVAEIPNYTANFWKTIYSFSI---VCTDSPSMNEANLFLEASLNQNYGIKIFSSKVITYAIVPTIITTIAT------YFIGIAS------YQRSRIYACFDKANDTKCLVD TuGR252/1-375 ------M-----NKTVDV-QSW-ELDA------DSQVKRPTSIYSAIV------DSFFINRF------IWKHRRFHLFLSLLG--IG-AFTARTIAFI-LE----II-----SNPNSP------N--LSI------SSFILYA-ISQVW------VLYAVLENFA------FPS-----VKFIKSFDEIWSELP------LSSEP-EIVTAIKKSNRFSNI------VSFCILINSITIL---IA---SSTIE-----YLSTLN------ASIIYF---LGNKSVELYANLIIANI-----LRGFLISGGYIKIGHQYIYNEIVA------IAG------DATAPDLSF------CRLRHEHHDLVQCGHLCDAAFRRFVTTVCSVQVPMAVLIIYNNLYM-DIDVI----TRVNYFLALLDFGTFIAFFVPCLVGFYSFPSQARDYIYFSTL---VGRSNLFKSEALHFIDMINLKSCGIKFMGLYLLTPDIIPTFATIVFT------YVMAIPN------FRNAV------TuGR250/1-381 ------M------ISDV-YSLYEIKVSH------NTVKSPTTSIYNSIV------NSFFINRW------IFRYRWFYYFYSLLA--LT-VLSIKTTLFV-VE----IF-----TNFSPK------S--ID------SFFITYI-VSTTW------LLCTVLETLV------YPS-----AQFIESFDMIWSQLP------LSKES-AVIDELRESQKFANI------SSSIIFTTGSSIT---LI---TGAIE-----YLNHIGSSNS------SDKFYF---LGNKLIEIYSHLIFINI-----FRGFVIAGNYIKVGHHYIHRRITE------IVR------DFYASDLTI------YRLRHQHYDLVRCVELCDFGFRRFVTVCCSTIVPNIILILYNLGYK-PLDLQ----SSIVYVLLFFQYVIAMSIFFPVLLGFHSCPGLALDDLYLSTL---VERSNTFKSEALIFMDLLNQQSCGIKFMGIFLITPDILPNLATIVVT------YLMAVPN------FITSNKQ------TuGR251/1-385 ------M-----TTIKDV-YSLSELNVSHN------PMMESLTTSIYNSIV------DSFFINRW------KFKNRWFHYFYSFLA--IA-SFVIKTTLFV-LE----II-----SNLNSK------S--LD------SSVISYV-ITEVW------LLFIVLETLV------YPS-----AQFIESFDTIWTQLP------LSKEP-DIIKELMKLLRFANI------ISITLFMTGTVIS---IV---SGTFE-----YLSHLEAASK------SYKYYF---IGLKLIELYSNLIFVNI-----FRGFYICGAFIKIGHCYIHRRTIE------IIK------DAYASDLTI------YRLRHQHYDLARCGELCDLTFRRFVTICCITTAPNTILILYNLAYT-NLDLT----SKICNILLIIQFSIFLLLFFPCLIGFYSYPGQSRDDLYLSTL---VERSNTFKSEVLLFMDLLNQRSCGIKFMGIYLITPSIVPNLATLVFT------YVMAAPN------FFTSNKQA------TuGR256/1-415 ------M-----DVKPAL-ANWLNPNIDLNVKRAELT----GTSNSKPLSLVNICI------HSVPGISFFC------TNTIGVKLSQLVNLIAVGLLFVRAAKTVKDI-IE----VVV------IQ-----GENILLERT-NRMLTSL------A------KSISNMVVLYTC---ITLNL-----PSFLHSMDLIWFHLP--FI------NQATFISTQRFHLWLGFILYGLFNAVDLIFRITVK---V------MYPTFSVY-PDMLIFNISNYTIIQVCLCKICL------ICFIQVITIFVSTGFKEIAKQLED------VNF------EPSDKGMPKLSPFFIYHGTAWLANHRKSFELLNEMVNLTNKKFHLFIYSAIICIIPASITIIYDIIFA-EMELK------IYHVIDITFNIIFIEILIYYLSLFNLHSHRIWLALYRLTL---ISKNEMTTLEATLFMNRISNLPVGVQLSDKFVITLGVGPSLVAVIIT------VFVSITS------LNQVFLNNANATNNN------

TM 1 TM 2 TM 3 TM 4 TM 5 TM 6 TM 7 intron

Conservation ------1------000000000734243-00------0------221336525----46-4344124214-00------0000------1--1------00100----44314-402------4424446261------010------41623632272222------20140-151347251422222------5434444414421---0----00000-----00000------0-114412----4213440322441------234667547454566415112521------100------1000132218------415+23831522355167474323634563244314322441441--202------34244244214424444542473951282344217+4897---224431423+5188703123279+85853546996447698457549------6687477------841------

Quality

Consensus MNSLSIM++++D+QTLKVSLFGVCFSV+MLRIQLSSINMQ+QCFVRNESLKN+F++TT+TRKLSYPKIKPSSILAKGL+L+PSKFNQEH++SPTVN++EAKR+FLRLT+++ISNTEDNTSEDKSLTNNEDKP++DSYILSIFCND++++VDELQN+WLNSTSNRKSKFLFLTI+GLL+LLALKGLIYLIYYIFGSLFST+PFCNYSSNTP+LSENK+ELGI+R+VIIDSKFECN+IRIILYIDYIL+WSAGLVDSFGSRLD++++TLFLNESLGFILLLFRVSGP++FNRQE+FR+KLYKEFIDHWESLQSP++DQPT+RIIDFDPPSTRKYIKKNRKIIRI+FILYGFLLIIAFI+Y+ILTL++I+SDGYYYIQLD+LWYFQKSSK+FKLFSSYYSLLWKNILLIWLLLIFRLIIYFGYFLL+NI+LLS+LQFIIELCIYLQAAF+FINSQIASHKRIQSSSLNNESKL++NKSSSSLNIDEIAI+FI+++++++RSIRRLYSIAIRLTRKADSFLRPFIFFFYVYFIGY+IFNFVRLIYPIEQSIS+IFNDKLYSLIRFIGELIYLILLTYHLVY+NHLSTEIFEDVYSLSFSLNKTDSIELLNEINLFLTRINRNDVGFTFAGLFLITPSFVTSLATISLTNLWEEIMLQIIILALPSDEDQKNRENCLRNRFIKQSKSS+N+T+N+++CLI+

Suppl. Fig. S3. Alignment of T. urticae GRs from clade A.

Alignment of TuGR-As using MAFFT v7.266 with visualization using Jalview. Transmembrane domains as predicted by Phobius for a representative receptor (TuGR236, first sequence in alignment) are shown as black rectangles with the position of the single conserved TuGR-A intron indicated by an arrow (beneath alignments). Default tracks from Jalview for sequence conservation, quality, and consensus are shown at bottom. 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 TuGR35/1-416 ------M------KLVK------SLTDP------LVK-M------LDR-QLSPE------SLRPKVRRL--EKMGKITK-TC-VLGYAQ---KGRMGR------LNHTLHTL---SHIWFIVVVARSIRLLL-F------DDPNETIYLGDFFSQTKG-KE---FLHFLIIVYYLLFF--ASRAGAH---ISEARKPMLM-L------KFYG------KIEKHG-FD--SMCRLLTPTKFKNF-----RIV-LY------SALQFYFIGIP------IIALSLFVLCITF----AL------QTSTF-YL------SIYHS-I----WFVFWVIII------TGPLALNIYSLFWFYTHFISLITYCSMSLGCA------YDLG-GI-IQSD------VGKHLD------L-LAD-----Y-LKRQNKILNLIRSINCDIGPTAFVGYIIATFLANFSLFLAIFVTSESN------AMKII-CFGLAIIAYTNLTLLHFAGTVV------HERLMEIRERN-FSIQAR-----GVNLI--PLPMAVWINSTLERIENGENGISVTHIF-VMRQSSFLFFVLENSGILMM---FVSNFVKS------TuGR34/1-419 ------M------LT------KLKTK------IES-F------VEN-QANEE------HFIKAFGKL--ERIGSIVS-AN-IRGYKQ---EGSMST------FHHIYHFC---SHIWFIIVVARSVTLIV-S------DDPEDSLYLGDFFSSTKG-KN---FLHANIIVYYLLFF--SSRAALH---IADSRKPQLS-F------QFFN------TIKLNG-LS--TARKFLTSKHEYTW-----RFY-SY------IALQFFFIVIP------IVAVSLFVLSAIF----AL------ENPAL-YK------SIYHF-I----WYFFWILIV------TGPLGANIFTLFWSYTHTMTLSNYLFLAFTSV------DHIG-AR-ILKKMDSGQTA------NNLD------L-IRE-----F-IRRQNSLLNLLKAINSDAAPTMWTGYLISCFLADFNLFLGLFIDGGSP------VMNII-CFALACTAFSNLLLLHLSGIAI------NNTIAEIREKN-FSIQAR-----GVKVL--PESIALWINSTQERFENGETGFSCCHIF-ILTQSSFLFSVLENSGILMM---FVANFKKS------TuGR40/1-424 ------M------SQFWK-L------IDN-KCQPD------DLVRLFDKL--EKVSKSTW-IC-LNGYSQ---SKKV------DA----VKIYGNFF---LCFYCLLTCLRFLTIAL-V------QDEIIRIVLGDTFIGHSE-HM---LLNIMCFGTSAILV--SVKTAIT---YGEFRSRLQI-L------QFFS------HLRSVK-FS----TFHSKQVNDQKF-----RRL-IF------LLGRSLHTFIY------IACSSIAIIHIQA----MI------RNPQI------SREIF-L----FQLIWLPWA------NGTFYLAGLAVYWFFIHVVIFISFSVQLMDSA------IDAT-RE-LNRE-MMTNEHE------IKVIER------K-LYR-----L-YKSQNDHYNQIDLFLDNFSSSTFLSFFMGSFFADLSFFCGNYVGTGNF------VIDFV-LMFLGTIIIANILQYALFASGS------SKKIENFRKMI-YHILRT-SSNYHAMSL--SLKIKIKFLTTLERMSIKKIGFYVGTLF-CMDKYYCVIFLLENISLYLL---FVSNITKNQPANLEMD------TuGR38/1-440 ------M------EYENR------RKYFVSKKVNFVP----PLN------SPS----SFLEK------LLD--S------IDR-LSVPS------KLVKLIDHL--ERSSIASW-IC-INGYSQ---QNKP------AR----SKLIFNIF---LCLWCYANSLRHLTIAF-I------QDENSRILLGDSFIGYPA-YS---LLNIIFSGAAFLLG--SIKTALV---YSESQSRMQI-L------NVFG------SLRDKS-FD--RSIWGMTKNCDLKF-----RRL-TC------LTSYSLDIFIV------TAVGSTITMQIQA----MV------LNPSI------SVRTF-L----IQLAWLPVS------NIAVYFSGLAAYWFFVHTIIFVSLSIQSTSSA------IIRV-DK-LIKS-VKVSYSH------SVTMT------V-IQR-----L-IQMQNAHYNTIAILNDNFGLSVFISFFVGSLFADLAFFCGTYVSTKNI------LLDLL-LSFIGFITLGTITQYNLFASGS------FKKIEKFRKAI-YRLSVN-I------PF--DLKTRFKLITTLERMSTYKIGFYIGNIF-CIDDYHCFIFLLENVSLYLL---LIANISKATN------TuGR36/1-445 ------M------GHKGR------RKYFCCKKVNFNPNFVSSLN------SSS----SFLQK------ILD--S------IDR-LSEPS------KLVKLIDHL--ERSSIVKW-IC-INGYSQ---TNKP------AR----SKLIFNIF---LCLWCYANSLRHLIIAF-V------QDESLRILLGDSFIGYPA-YS---LLNIIFAGAAFLMG--SIKTALV---YSESQSRMKI-L------NVFG------RLRDKS-FD--RSIWGMTKNCDLKF-----RRL-TC------LTSYSLDIFIV------IAVGSVVIIQVQA----MI------LSASI------SVRTF-V----IQLAWLSIS------NIAVYFSGLAAYWFFVHTIIFISLSIQSSSSA------IIRV-DR-LIKS-LKVNYSH------SSTMN------V-IQR-----L-IQMQNAHYNTIAILNDNFGLSVFIAFFVGSLYADLLFFCGTYVRTRNI------LLDFL-LFFTGFITIGTITQYNLFASGS------FKKIEKFRKAI-YRLSVN-I------PF--DLETRLKLITTLERMSTYKIGFYIGNIF-CIDDYHCFIFLLENISLYLL---LITTISKATTN------TuGR39/1-431 ------M------KSL------YRRY------SQCVNQR------LV-----QNTGQ---VSYSTS------MIR-L------IDN-WSAPN------QLVKLFNRL--EKMGKATM-IC-SHGYSQ---VTAS------TT----YQVVLNLL---LCFWCYLISFRFLLLAF-L------RDEKMRIILGDTFIGYQA-HS---LLNVIFFGASFLLT--SVKTSLA---YSESQHQMQI-M------TVFY------NLRETW-FN--PVHHGLTDEDDMNF-----RRI-TC------LAGLSLNLFIN------LSCGSIFILQIQS----IL------LNPCF------SLRTA-F----LQFLWLPFI------DVTMFFSGYACYWFFIHIIIIISLSIQSTNSA------IVRV-LH-LLKP-KPYSV------S-LEK-----L-IYLQNAHYNTISMMNNNFALPIFISFFVGSFFADLTFFCGTYIGTRNF------LIDIL-LALLGFLIFATIIEYNLFASKS------CHKIETFRKSI-HRLLIS-T------RF--DLRIMLKVTRTLERMSTDRIGFYVGNLF-RLDGYHSIVFLLENVSLYLL---LIANISRKSL------TuGR41/1-480 ------MVLTNFEQNSSNLYKKLSSNERSGRAQLAAQITAQSAYQPAYQSK------YNPYSSDQVK-KP---SWLK------SKVK----NWPEK------LSK-W------VES-HATDS------QLIYLLNYM--EQQSKSRL-IV-INGYNQ---KENR------SLNK----FKMAANFF---LCFLNFVIVIRFGVLAW-L------QDDEMRGILGDCFIGFFG-KE---ILNATTCIAFFVFA--SIKLSMA---YQEFKAPITY-L------CFFN------KLRNIK-FR--GNKLLLDPQNETKF-----RKL-IL------VLGYFIIMSTY------LVWLPILMIHLFS----MV------TNPFF------TYPLF-I----CQCVWLIPI------HISVFLSLQASWWFFFHLIVGISYATGVFNSL------ATFG-HR-VNNK------IIKTNPK------E-IIA-----F-FQSQQRQFNLIEEVNRQLTWGTFAGYIFGSLMSELIFFCSTYLGTGSN------IVDNL-LLYLGLGFFGVLIAFNLFAART------QSQIVRCGLNN-YRLSTI-W------PS--NYSIYFKASVTFERLSCNTMAFYVGQLF-PMDDFHFLIFFLENASLYLL---LITNISAKTGRQN------TuGR47/1-417 ------M------AGK-TDENYFHR------W------LAL-KSTKE------KSVDLLNAF--EMSGYRWF-ST-IRGYKQ---VKPI------TR----KHYIIGLT---IDFLGLITVLRGFLIIL-I------PNSTIRILLGDLFVGSPA-EE---IQVSLITMLFTLSS--GLKYNGF---LVERKGPIRV-Y------QILY------HEIRVSK-FD--RKQFMLTREDDSSL-----RKG-WY------LFGRFYFIATP------LTCLGIAGWLIFA----FT------VNPIN-YS------NPVNL-I----ATSFWTILT------SIIFTLGAYSTIWLYCHNTMFIPFVTLSLNSV------QKLG-KS-IMGH-KK------TAQG------D-ILK-----Y-FAQQNRIYNFIHLCTTDLGTIISYGVLIVSATADFAMFTSIFIGTGSD------LFDYI-ILSVGIMSFGAIVGINVFSAFT------THRIALCNSVN-YQLARR-C------KL--DLQSSIKLLATCERINTAPIGFTLSGIA-IMDSEHLLLYLLENAGLMLM---FITNFNKATVN------TuGR42/1-452 ------M------RYIKYRM------SIFD------N-Q-LPDSFAFR------W------LAR-RSTVQ------KSIDLLNYL--EHSGYYWL-TI-IRGYPQ---EKEI------ER----KYYRIAAF---ANTVGAILIAKTALTIC-L------KDDYTRLLLGDIFIGSFS-HG---IQNTVLMMVLTLVI--GLRYFGF---LTERLKKVVI-L------RKLH------QLREKR-FD--CTTFMLTPRANSYM-----RLY-FY------LFGIFYKMTNA------FVCTCVSGWLSYN----YL------SNPIN-HT------SWLTS-I----TTGLWSILT------AFVYAAGAFPTIWFYVHNTMIITFAIFSLDSC------HNYG-QA-MANL-NCK------VTKK------A-IYK-----F-LTQQNRIYNYIYQHTVDWGKLFFYGILVVSGTGNFILFAATFIGTGSD------LLDYA-LLVLGFVTFNSISIMNVLAAFA------ANKITLNRLCN-YKIARR-C------KF--NLRLSLKLLTTCERLNLNKVGFNLGGIC-TLDSEHFLLYLMENAGLMLM---FITNFNKASSNQQLNVPNQIQRSD------LNVTN---QDT-SISW TuGR43/1-449 ------M------SYTKYEE------PVLD------G-Q-LHDSYLLR------W------LAR-RSTVQ------KSIDLLNYL--EHSGYYWL-TT-VRGYPQ---EKEI------ER----KYYIIAGF---ADTVGAILIAKTVLNAN-I------SDDYTRLLLGDIFIGSSS-HG---IQNMVLFMLLMLAI--GLRFFGF---LTERTRKVII-L------RQFH------QLREKR-FD--SATFMLTPRANSYM-----RQF-FY------LFGIFYKMTNA------LVCTCVTAWLTYV----YL------SNPIN-HT------SLLIS-I----TTGFWTILT------AAAYTAGAFPTVWIYVHNTMIITFTFFSLDSC------HNYG-QS-IVKA-NCR------VKKK------A-IYR-----F-LTQQNRIYNYIYQHTVDWGKLFFYGILIVSATGNFILFAAIFIGTGSD------LFDYA-LLVHGSVTFNSIGIINVLAAIA------SNKITLNRLCN-YKIARR-C------KF--NLRLSLKLLMTCERLNLNEVGFNLAGIF-PLDSEHYLLYLLENAGLMLM---FITNFNKSSSNQQPSIPLQTQ------NVTN---QENPSTSW TuGR44/1-437 ------M------NYIKYTE------SVLD------N-Q-PHNSILLR------Q------LAR-RSTVQ------KSVDLLNYL--ERSGYAWL-TT-IRGYRQ---KKKI------QR----RYYYIGAA---LDIIGIILLIKCFFIVF-L------QDEYTRLLLGDIFIGSPS-HG---IQNMVLAILLVLTV--GLRYFSF---LVERLGNVII-L------RQFH------LLRKKR-FD--CGTFMLTPVDCSLL-----RQV-FY------LLGFFYKTSLP------PLSYAITGWLTYA----YF------SNPLN-HT------NWLTS-I----TTAFWTILA------DFIYITGAYPTVWMFVHNAMVVTCAIFRLESC------NFYG-QS-LINE-TCK------IEEK------A-IYK-----L-LAQQNRIYNFIYQHNVDLGMLFSYGFLIVSCAGNFILFAAIFIGTGSD------LFDYA-LVGVGALAFNSIAVMNILAAFA------ANKISLIRLLN-YKIARR-C------KF--NRNLSLKLLMTCERLNLTEVGFNLRGIF-TLDFEHFLLYLTENASLMLM---FITNFNKSSSNQQSSVQVQNT------TuGR45/1-451 ------M------NYIRYSE------SVLD------N-Q-PHDSILLR------Q------LAR-HSTVQ------KSVDLLNYL--ERSGYAWL-TT-IRGYRQ---EKEI------QR----KYYYIGAA---ADIIGIILLIKCSCVVF-L------QDEYTRLLLGDIFIGSPS-HG---IQNMVLTMLLVLTV--GLRYFSF---LSERIGNVVI-L------RQFH------LLREKR-FD--CGTFMLTPVDCSLL-----RQV-FY------LLGFFYKTSNP------SLSCAITGWLAYA----YF------SNPLN-HT------NWLTS-I----TTAFWTILA------DFIYITATYPTVWMFAHNAMIITFAIFSLKSC------NYYG-QS-LINE-TCK------IKKK------A-IYK-----F-LAQQNRIYNFIYQHTVDLGMLFFYGCLVVSCTGNFILFSAIFIGTGSD------LFDYA-LVGVGALAFNSIGVMNILAAFA------ASKISLNRLLN-YKIARR-C------KF--NRHLSLKLLMTCERLNLTEVGFNLGGIF-TLDSEHFLLYLMENASLMLM---FITNFNKSSSNQQPS---NNTIPNCG------LNGTS---QEAMGLC- TuGR46/1-454 ------MM--NFR------EML------FKFSCNCCSMRLFLMSYLDMES------DNLD-----RDSNS-LCKSFGFK------SIELW------LTR-KSKVK------LAVELLDEL--EDSGNRWL-CT-LRGYQQ---KSSV------TR----RKIFVNWI---LALVGLVITLKTFLTTF-I------SNKFIGILLGDIFFGLPG-HD---IQNMLLTMIFLLSS--GVKHVGF---EKERLNRYKI-L------RVYH------KLRETQ-FE--YDELMLSQHDCTQI-----RKF-IY------LFGQFYKIDSP------AVSIAIPVWLLLI----YL------TNPVN-QE------SLFNA-I----ITGLWTLIT------AIVFIYGAYATVWSFIHNTLIVVFVIHSLKSL------YSYG-ES-ILDQ------GCSEA------Q-ISK-----Y-LTQQNRIYNLVHQHVVEMGMVTGYGIFVVSCTGNFALFVSIFIGTGSN------LTDYV-ILAVGCMNMTSIVTLNTVGALS------ANMILSCRALN-YRIARR-I------RC--QFKYKLKLLMTCERLNLTRIGFSTGGIY-KLDSESFLLYLLENAGLMLM---FITNFNKLNTQ------TuGR49/1-418 ------M------LTDFPFNW------LA------GLK---DDLIAK------GVN-Y------LER-NTSTE------QLVDHLIKM--NDLGKFWL-VC-IRGYSQ---KGII------PV------KKRLISTG---LDALCITVLGYIIFLAL-T------ADT------RK-QSVQIATSIFILINLL--GIRWASI---YCEYIDQYTI-L------RFFD------DIIRTGSFD---IHCLLGSTNCNLF-----KWF-TF------ILLQFYSLSTI------ISGIALILYHIFA----VL---R------V---DLKLGWTLLTDVTILITVPSVAFVIIFVVHNVTWCFTHIIILMIHSAFALDNI------HKKAIKS-MTTS-KCNADP------TQADSN------D-CAE-----Y-WHSSNFCYNQIKIMKYQLSPITFYGYLLGCLGTDFALFTGAIYGTGDS------TLNYI-ITGLGLLALQILTMVNEASAFA------LRIISKCEKLN-YRMSCC-C------KC--QTTIKLKGLLTIERMQYSKVGFYVGQLF-LMDNLQYLMFLLENGSLLLL---FVTVITR------TuGR48/1-453 MYES-GL------M------QIGNCQKL------TQSR------PLNQFFAI------LL------KMQ----NMFNQ------FLNHWST----YLDR-RCSKT------NLIKDLNTL--ESSGYFWF-AC-NRGYSQ---SKTV------SK----NRIILNIV---VDLWSVLATVRFLLLAI-F------SSDLFKIMLGDHQLGIPG-ED---AFNLLSFIAASMFL--IVHLSIG---YLEWNNNFTV-I------RVFH------QIRQLH-FN--LDKI-MGSYNCSNF-----RRV-FF------FMSQSHAIMTK------VTCVGTAGLFITN----MV--L----FDASK-YK------NE-----IISYKQFF-F----LELIWLAII------IVPMVVLIHNVFWSFTHIILLIVYTSLCLDFL------YSSI-DS-NNQL------VPAT------VLIDI-----F-IKKQNYYYNQLLITERQLSPITLAGYIIGSLMADFALFYGLFIKTGSV------LFNVL-TITLGIVAFGALTLLNIIAATT------VDKVKKCRLMN-YWIIRS-GQ-----SK--TLSSQIKLIAIFERLSTHPVGFFVGRLF-VIDNHRFLLFLLENISILLL---FITNMTRLWKN------TuGR50/1-428 ------M------QRV------KKF------PE------LV------TKARALSRFNK------IFG------DIVDPK------DGLEHLDFL--EKSGKTWL-IC-LGGYNQ---STQY------HP----GYLLTSIA---IEAINWFLISRLIILCL-T------DNHNLSFYLGDIFYGTST-RF---YMNAVFGVSSILLG--GIRSFIF---WSEQFKNLHW-M------NYFA------SIKKNG-FR--TDMLHISQSDLKIL-----RSR-LY------ISRKIFTFFTP------LTIISLASIFTFA----VV------SNPVT-YS------STVRL-I----FIIGWTGAT------FVAAVFAIATAIWMSIHVYVLIVYTILRLDHI------TRVT-EG-LIRL-PI------IPVH------L-IRS-----V-INEQSSLFNSIDKMNNQLSNLFLFGYNYAAFAADFLLYIALIMPKDNL------FNNVL-VFGFGIEASGIVIIIVYLSSTI------HIKTHQTYSYY-HEMIEK-L---PNVML-NETIINYKILGILERIGGPVIGIYIGTMF-PLTYYQFATFLLENASLMLL---LAGALQNIM------TuGR51/1-446 ------M------FCFKI------YSSSTTLT------MKFRA------IA------RFK----RFVSHIN-----QFFG------QNLDP------FKGIEHLYFL--EESSKRLY-IS-YRGYSN---EKT------KLST----DYLLKSVL---IEIGNFLAIGRLTLLCF-T------SNAFVTTYLGDFYINTTI-RF---YMNNTLAVVGWLVV--LMRSMLF---WQDINHQREW-L------STFA------FIKCHG-FN--ASLLKITSSGANQL-----RNK-VY------LTRIFYTVTSL------FTAFFIAALIFYS----FL------SNPYS-YL------SRRLL-F----CQLFWASLT------IWQAYIDVSSTVWLVAHIYLLTVYCSLQLDAV------DLSI-AR-ILTKRSSNGKSP----HFDQC------LPNQ------A-LRS-----L-VVDQNYAVSCIYKFRSQIKHFISLGYFYACFGADFMFYSVSVMPTDQI------LYNII-VAGLGVETMFISMTIILILSKV------SAKAAESYGKY-HMIIEE-A------KP--GVTTKRMVSGVLETIGDSFIGFYIGDVF-KATMNQYVEFVLGNCSMMLM---LISTMRQIS------TuGR52/1-430 ------M------SIIRKV------FLLK------SYVLNT------YY------KIR----SFCFNFS----FNSL------NNH-DVTRNDL------LNAIDDLERF--ERSARIFD------RR------KNCK----YFQLQSLI---ILVLNSFQALRFLMLNI-T------DNETLRLYAGDIFVSLSE-RK---VLDYIVHVGIIMPC--MVKIFLL---HHNKFGRKSF-I------NIFD------EYKESL-KQ-YKREFSLLSTNESSF-----RKS-YY------ILIKLYNYFNL------MVYIIFGLAHIST----AV------IN----YS------SLKPF-I----IQLVHTALI------IAIYYFIISSALWFLFILALVALFSCNSIDSL------ITEY-DK-LNSI-NH------YAWT------N-KLS-----F-YYKINLLNNWIDCFNAQSAWLMYFAYMYAAFHNILIFFYLTQFTFDNL------GVKTL-LITSNILILLILYVSNYLGSLI------AQKGSLLYMSI-YRASVD-T----GKSN--NLEVALKKLQVLERFKARKIGAYIGNYI-YIDNNNALILTLECASLYFL---FCANIHRNTL------TuGR442/1-430 ------M------TTIREV------FPIQ------RYIFNI------LT------EIE----RFCLYFP----SSSI------KNH-DVTRNDL------LNAIDDLERF--ERSARIFD------RR------KGCK----HFQLQSLI---ILVLNSLQASHFLLLSI-T------DNETIRFYAGDIFVSSSE-RK---VLNYIVHVGIIIPC--MVKIFLI---HHDKFARKSF-I------NIFD------EYKESL-EE-YNKEFILLSTNEKSF-----RKS-YY------FLIKLYNYFNL------MVYIVFGLAHTST----VV------LN----YS------SLKPF-I----IQLIHTALL------LAIYYLIISSALWFLFIMILVALLACNSIDSL------TIEC-GK-LNSI-NH------YNWT------N-ALT-----F-YYKINLLNNWIDCFNAQVATIFMAVYIYAPFHNILIFFYLTQFTFDNL------GVKIL-LISSNILILIVLYASNYLGTLI------GQKGSLLHLSI-YRVSVD-T----GGFY--NLKVALKKLQVLERFEARKIGAYIGNYI-YVNNNNTLILTLECASLYFL---FCANINRNTL------TuGR53/1-429 ------M------PLIRKF------FLLK------RYIHGV------WN------KTQ----RFFLNFS----IKSI------NNF-DVTRNDL------LNAIDELKHF--EHSALIFD------QT------KSCK----YFQLQSLI---ILILNSMQALRFLLLSI-T------DNEVIRLYAGDIFVSSSE-RK---VLNYIFHVGIILPC--MGKIFLF---HLNKFGRKSF-L------NIFD------EYQESL-KQ-YNKEFILLSTNEMSF-----RKS-YY------ILIKLYRHCPI------TVCFIFVLSHGST----AV------FN----YS------SSKSF-L----FQIVHLALL------VPIYYFVAASALWFLFIVLLVASFACDSIDSL------TTEC-DK-LNSI-NH------YAWT------N-ALS-----F-YYKLNLLSNWIDCFNAQVAWIFMAVYIYATFHNILIFFYLTQFTFDNL------GVKIL-LIFSNILILTIIYSSNYLGTLI------GQKASSLHLSI-FCISID-T----GTFF--NLKVALKKLHFLERIKACEIGAYIGNYI-YVNNNNTLLLTLECGSLYLL---FCSNINRNN------TuGR54/1-437 ------MNWNT------LRDTSIIPKF------LHLK------RFILDN------WN------KMQ----RFFSNFS----SKLI------NNL-DVANNDL------LDAIQDLENF--ERSTKTLD------RA------KSCR----YFQLQSLI---ILLLNSVIAIQFLVLSI-T------DNETIRLYNGDIFVSSSE-RK---VLNYFLHVGEMIPC--MVKFFLL---HLNQCERKSF-L------NMFD------EYKNSL-VQ-VEEKFILLSTNERSF-----RIT-YY------ILIKLYKHCPI------MVCAGFALAHISI----AV------FN----YS------SLKSF-L----FQMVHIAFL------GVSYYFISSSGLWFLFIMTLATLFGYYSIDSL------STEC-NE-LNSI-NH------YTRT------N-ALS-----F-YYKINLLSNWMDCVNAQVASIFMALYVYLAFHNILFFFYLTQFTFDNL------GVKAL-LIFSNVLISMLLYVTNYLGSIA------SQKASQLHLAI-YRLSID-T----GNLF--NLKVSLKKLQVLRRIEARKMGSYVGNYI-YVDNNFILLLTLECGSLYLL---FCANINRNN------TuGR55/1-429 ------M------ARF------ILSY------YCYSK------MK------NIK----NIRFGFS----IKSISKF------SNL-NVTKSDL------LRAIDDLEHF--ERSTRTFD------RS------KSFQ----YFQLQSLI---ILLLNIMLAMKFLLLSI-T------DSETIRLYAGDIFVSSSE-TK---VLNYFCHMGAIMPC--MGKIFLL---YLNQSERKSF-L------DIFV------EYKESL-KG-PDAESSLLSTRENLF-----RKQ-YY------FLIKSCNYAPF------VVVSFLLIAHTSM----VT------IN----YS------SLKLY-I----MQIIHIAIL------GVVYYNSIASGIWFIFILVLAALFACNSIDSL------ITEC-SK-LTSF-TH------YTWA------N-ALS-----F-YHKSNLISNWLDCINMQFAWIFIVAYVYLAFHNILIFFYLTQFKFGYF------GVRVF-LIFINVLTLTVLYSCNYLGALV------GQKTSLLHLAF-YRISID-T----GNLF--DIKVALKKLHFLEQIQARKIGFYIGNYI-YLDNNNMLLLTLECGSLYLL---FCSNINRNNQ------TuGR56/1-430 ------M------ARF------ILGY------CCCYSK------MK------NIK----NIRFDFS----IESISKF------TYP-NVTKNDL------LRAIDELEHF--ERSTRTLD------RS------KSFQ----YFQLQSLI---ILLLNIMLALWFLVLSI-T------DSETIRLYAGDIFVSSSE-TK---VLNYFCHMGAIIPC--MGKIFIL---YLNHSEKKSF-L------DIFV------EYKESL-KG-PDAESSLLSNRENLF-----RKQ-YY------FLIKLYNYAPF------VVVFFLLILHTSM----VT------IN----YS------SLKLY-I----MQIIHIAIF------VVFYYFIAASALWLLFIVVVAALFACNSIDSL------TTEC-GN-LNSI-TN------YTWA------N-ALS-----F-YHKPNLLSNWLDCINMQFAWIFMALYVYLAFHNILIFFYLTQFTFAYF------GVPLL-LIFTNVLILTILYSSVYLGALV------GQKVHLLHLAF-YRISID-T----GNLF--NIKVALKKLHFMEQIQARKMGLYVGNYI-YVDNNNILLLTLECGSLCLL---FCSNINRNNQ------TuGR57/1-416 ------MQ------NIK----NIRHDFS----IKSISKF------SNL-NVTKSDL------FRAIDDLQHF--ERLTRTFD------RS------KSCQ----YFQLQSLV---ILLLNIMLAMKFLLLSI-T------DSETIRLYAGDIFVSSSE-TK---VLNYFCHIGVIIPC--MAKIFIL---YFNQSERKSF-L------DIFD------EYKESL-GG-YNKEFTLLSTKENLF-----RKQ-YY------FLIKSYNYGPF------VVVSFFLILHTSM----VT------IN----YS------YLKLY-I----MQIIHIAIL------VVLYYYIIASASWFLFIMVLGALFACNSIDSL------TTEC-NN-LNSI-TN------YTWN------N-AFS-----F-YHKSNLISNWVDYVNMRFAWIFLALYIYLAFHNILIFFYLTQFKFEYV------GVQVL-LIFSNVLILAALYSCNYLGALV------GQKASLLHLAF-YHISID-T----GNFF--NIKVALKKLHFLEQIQARKMGLYIGNYI-YIDNNNILLLTLECGSLYLL---FCSNINRNNQ------TuGR61/1-424 ------M------KEF------ILGY------WCNSK------MH------RIQ----RFCFNFS----IKSI------INL-NVTKNDL------LSAIDALEGL--ERSARIFD------RR------NSGK----YFQLQSLL---ILILNIILAFHFLLLSI-T------DNQTIIFYSGDFFVSSSE-RK---VLNYILHCGIIMPC--MVKIFLL---YLHQSGRKSF-L------HILD------EYKGSL-KE-SNKKFSYSLKDEKLF-----RKS-YY------LAIKLYEYIFI------GVYGVLLLLHLTNIT--II------YN----HS------TLQQL-I----LQMIHMAIL------VILYYPILSSALWFVSMLLIMGILAYFAIDSL------KVEC-DE-LISL-GN------YTRH------H-AES-----F-FYKQSLLSNWMDWVNARAAWIFITFYAYGCFHNILILFCLTQFKYDNL------GVKML-LSFAYTLILAILYANNYSGTLI------GQKASVLHRSI-YRLSIN-T----GKLF--NIKVALKKLQTLERLASRKMGVYIGNYI-YVGNYTTLLLALECGSLYYL---FCANIN------TuGR62/1-422 ------M------REF------IRGY------WCISK------MH------RIQ----RFCFNFS----IKSI------TNL-NVTKNDL------LSAIDDLECF--ERSTRIFD------RR------KSFK----YFQSQSLF---ILILNIIQAFHFLFLSI-T------DNQTIILYLGDFFVPSSE-RK---VLNYIVHCGIMMPC--MVKIYLL---HLVKLDRKSF-L------NIFD------EYKSSL-QN-SNKKFSFPLKNEKLF-----RKS-YY------LFIKLYKYIFI------GIFIIFSLLHFIN----II------HN----YA------NMKHF-I----LQVIHMAIL------LTIYYPILASALWFALITMIMGIFAYHAIDSL------QTEC-DR-LISV-RS------HTRH------H-AES-----F-FHKHGLLNNWIDCINAQVAWIFITFYVYGAFHNILILFCLTQFEYDNL------FVKMI-LSFANILILIIIYGSNYAGTLI------GQKASILHRSI-YRLSIN-T----GKTF--N----LKKLQTLERLAARKMGAYIGNYI-YVGNYTTLLLTLECGSLYYL---FCANINRSNM------TuGR439/1-435 ------MS------KICKLLLNKL------FLGH------WCNSK------MH------RIQ----RFCFTFS----IKSI------TNL-NVTKNDL------LSAIDDLECF--EQSTRILD------RR------KSFK----YFQSQSLL---ILILNIIQAFHFLFLSI-T------DNQTIIFYSGDFFVSSSE-RK---VLNYIVHCGIIMPC--MVKIYLL---HHRQSYRKSF-L------NIFD------EYKSCL-QE-SNKKFSFSLKNEKLF-----RKSYYY------LSIKLYKYFSI------GVNIGFWLLHLTN----II------YN----YS------TLQRF-I----LQMIHVIML------LVTYCPLLFSALWLLLMMAVVSFFTCNVIDSL------KAEC-DE-LVSV-GN------YTCH------H-AES-----F-FYKQSLLSNWIDCVNAQVAWIFTTIYLYGAFHNILIFFYVTQFTFDNL------DVKLF-LIFCNSLILIVIYGNNYAWTLI------GQKASLLHRSI-YRLSID-T----GKSF--NLKVALKKLQALERLAARKMGIYIGNYI-YVDNYYTLLLTLECGSLYFL---FCTNINRKNQ------TuGR58/1-430 ------M------KRF------GLGY------RCCYSK------MK------KVK----KIRHDFS----TKSISKV------PNL-NVTKSDL------LRAIDDLEHF--ERSTRILD------RS------KSCQ----YFQLQSLI---ILILSLFKAIQFLVLSL-T------DNEATILYLGDFFVSTSV-RK---KLNYIVHFGTILPC--MVKIFLL---HLNQLNQKSL-L------DVFD------EYKESL-ER-PNKEFVLLSQNNQPF-----INF-YY------SCIKLYKYTSI------GVVCVFLAFHSTN----IA------YN----YS------SLNVL-F----FQLINLVAF------TPLYYLIFTSGLWLFIVAIILGSLIKLSISEL------TTEC-NS-LNSV-EE------YTWQ------N-AAS-----F-FYKHNLLSNWLDCFNAQFAWIFLAIYVYAAFHNILIFFYLTQFTFDDL------GVKLL-LVFSNLLVIIIIYGTVLYASVI------GQKAGLLHRSI-YRLKVD-T----GKSF--NLKVALKKLEALERLAARKMGAYIGNYI-HVDNNNTLLLTLECGSLYLL---FCTNINRNYQ------TuGR59/1-430 ------M------NRF------IRGY------RCCYSK------TK------KIK----KIRFDFS----IKSISKV------SNL-NVTKSDL------LRAIDDLEHF--VRSTRTLD------RS------KSCK----YFQLQSLI---ILILSLFKAIQFLVLSL-T------DNEATILYLGDFFVSTSV-RK---ELNYIIHFGIIMPC--MVKIFLL---HLNRLNRKSI-L------NILD------EYKESL-QE-PNKEFVFLSHNKQLF-----RNI-YY------SCIKMYKYTSI------GVICVFLAFHSTS----IT------YN----YS------SLKLL-F----FQLINLLTE------AILYYLIFASALWLFIIAMLLGSLTSLSISEL------TTEC-NR-LNSV-GK------YTWT------I-ATT-----F-YFKLNLLSNWIDCFNAQVAWIFLAIYIYAAFHNILIFFYLTQFTFDDL------GVKLL-LVFSNLLVIIIIYGTVLYASVI------GQKAGVLHRSI-FQLKAD-T----GKSF--NLKVALKKLQALERMAAHKMGAYIGNYI-YLDNNNTLILTLECGSLYLL---FCTNINRNNQ------TuGR60/1-430 ------M------KRL------ILGY------RCCYTK------IE------KIK----KIRFDFS----TKSISKF------SNL-NVTKNDL------LRAIDDLEHF--ERTTRTLD------RS------KSCK----YFQLQSLI---IFLLNLFYAMQFLVLSV-T------DNQSILLYLGDRFVSTSF-RK---ELNYISHFGTFMPC--MVKIFLL---HLNQLNQKSL-L------DVFD------EYKESL-QE-PNKEFVLLSKNDQLF-----RNF-YY------SCIKSYKYIPI------GTIFVFVLLQLTT----MT------CN----YT------SFNIL-F----FQCISLATE------IPLYYLIFTSALWLFIMAMLLGNLVTLSISEL------TTEC-KK-LNSV-EE------YTWH------N-AAS-----F-YYKHSLLSNWIDFFNAQLAWILLALYVYAAFHNILIFFYLTQFTFDDF------GVKFI-VAFTNLLLVIVIYVTILYATVI------GQKACVLHRSI-YQLTAD-V----GKSF--NLKIALKKLETLERLAARKMCAYIGNYI-HVDNNNTLLFTLECGSLYLL---FCTNINRNNQ------TuGR536/1-417 ------M-----PCSCTHCFAR------LA--ENL------ERSR------LP------SCS----RYLAT------IID-T------KSSKCNL------LKLIEQSEAY--ELSKWIFD----LRGTKR----K------RFLIVSGI---SLLLNFLVLLRLLVLCW-T------DNETVLMVLGDYFRTNRD-RK---LVNYYCFIGIFLLN--AIKIFLL---FLNYSFKKPF-T------FVFT------EYKDYL-EN--GRLYHLTLEDDQSF-----RRF-YC------TTLLTQKFTIE------IVYFGFFACHLSA----IL------FNS---YN------NLLSMGIDFFVFCIQFSVIRS------P------LLSTFWFILKSFTVITFVNYNLKSI------IKKG-EK------R------E-IET-----F-FYQQIWCYNYMDKMNIQYDAVTVLIYTIVTYIVVLIFYHLTNYAETLT------YTSEI-LLTFGISVISMTICVLHFIGSL-----ANKKTYQICIFT-HKLARY-R------SL--DLLASLKKLEILDRTAAMSAAFKINNQI-LLNNYLTLVYALECGSLYLL---FCSNMNRN------TuGR6/1-400 ------M------GKTR------IS------SNVNPQ------VEYPNIKIL-LHEHLVRLP-YL-PGIIYS------KKTLSYLFYLIAWPCIISGTAQYLLLAILK------RFANLTFYTIDPTLFLGS-TG---FWLLITCFLWSIIA--SVIRYFFQ--QSINQPNLQHWI------FPLT------VLENRD-IN--DKHL------RTI-IK------FTYAKVKFVLY------AVACAAFSFYIPI----LI------GL------PAQYL-P----WTLFNAVNT------AFHGYICTAWEFNFIFLLGFYLYYCGLRYSKL------TSSF-RRQLISQ-SVYHTEN---PQFNLTP------YYDE------G-LRR-----F-TQKIIKLAKEIDKAENFWYRVNNTVFMGTFLAETLLLYLTFFANTEG------AILCC-CIFLGLLTIFYGQSINFIPGIY-----LQHKFDEAVNDT-KKWINH-S------SYLARLRALTVLDYLTERHL-FVVFWCV-DTTTWNYLKVQAEVAMLLLL---LISNSRR------TuGR7/1-451 ------M------KNKL------VT------CWNKLFQL------VIT-IQ----LLIKA-NSEKRHSGMACSSKAYHSKLNSL-FRCHLAYFP-YY-PGNHYK------FGSLLWLIRLLAWPDLIYGCIKFASLTA-V------SSFKVAVVLGDFTWYMGS-AR---FWYLIVCFLWTLIAH-GVRTVCY---ISTINHRYQYWI------KPMS------ILETTN-DS--KREKQFTHELCYPLP----PLL-IK------STFIALKSALA------ISYFTGWSVNIPI----LL------FF------PISCL-P----LTILNSINT------GFHGFLAAAWEVNFSILFGFYFYYCGYRFNRL------ETIF-LRSLKSR-QSKYFETRFYERIK---KKRFPSISSTN---SFTLS-LVQ-----Y-EENILLLCKEIKKSRIFWDKTNNIIFMGTFLAETLLIYLIFFAKGVTS------VMLYI-MIWLGFLTIFYGQSINIIPGIY-----CQRQYNQCVATL-FNYVSS------GVPI--PVDVKVKVLNTLDYLVDDKV-LTVFWCL-YASSWNYIKVQAEIAMLLLL---LIANARS------TuGR10/1-406 ------M------LT------DILAS------LLFPL------KTLHSE------TIHPKLGEF-FKSCCLRYT-YV-SDGSFR------EHDLAWFLYVISFPALFLGTLRFAFLIFHV------GHPFYSTLLADFSFFMGQ-AS---FWFLLACLVWFVAA--LISRVYSE--ISNYKVSYQEWM------KSMI------HLQHPE-YS------RDLSTQRG-SK------LTLLILRFNLI------AGTICAAAVHLPI----II------GF------PIQWL-P----VTLAHTFFT------AFHGYLVGCYEVNFTILTGHYLYVYGRKHHRM------ASKA-KLVAAST------QSDYNE------YFIR------F-LTK-----F-KTRMISLSRDMVKINRFMAPVSSIIFTGTFLNETLCLYLTFFVDIEG------PPKYV-IRFLGFLTILYGQVIYFIAGSY-----AQHRYDECVTQL-HHLIEF-K----AMKI--PLSLRIKSLIASEYLTERKV-FTLLETI-DVSTINFIKVQVEMTMLLLM---LIGNVKRSYN------TuGR8/1-423 ------M------LKSPSFEV----SPLSKSK------VESLITI------LV------K----YLFQV------FVS------ITNNN------QIVYPLSRL-FKMNCLRII-YI-QNGFYI------KYSFSWFMYIVSLPIMIFGTIRCFSLLLYN------KNPFYSKILGDFSYHMGK-AS---FWFLACCFGWFSAA--IISRCLLE--FSNYRKNLQHWI------KPLF------YLENPY-LS------SDIKTRNA-SH------LTQILLTFNLV------AGAFCAASIHLPI----II------RS------QHEWL-P----YTLILTFTA------GIQGYLIGSYEINFTVLNAFYLYIYGRKFALL------GENA-ISVAYST------RSECCE------HFTS------S-MER-----F-TSRLTLLAQHMYKINQLMEKTISTIFVATFIAEAICLYCMFFVHLNG------STKYI-IQILGILTILYGQLIYFISGTY-----AQHKFDGCIAQL-QYLNEF-K----ATQM--PLSLRFKALVTTEYLTGRKL-FRILASI-DTCTMNLIKIQVEIAMLLLM---LIANAKR------TuGR9/1-423 ------M------LKSPSFEF----KPSSQSK------VESSIAI------LV------K----YFIHM------FLF------LINSN------KTVYPLSRL-FKVNCTRIM-YV-QNGFYI------KYSFSWFVYIVSLPILIFGALRFFFLILYP------HHPYYSKILADFSHHMGK-AS---FWFLTACFGWASAA--IISRCLLE--LSNYRKNLQHWI------KPLF------YLENPY-LS------SDIKTRNA-SH------LTQILLAFNLV------AGAICAASIHLPI----II------RS------QLEWL-P----LTLILTFIA------GIQGYLIASYEMNFTILNAFYLYIYGRKFALL------TENA-IIFAYPT------QSECYD------HLNS------S-LER-----F-TSRLTLLTQNVDKINQFMEKTISIIFVATFIAEAICLYCMFFVHLNG------SKKYI-IQILGILTILYGQLICFISGTY-----AQHKFHECVAQL-QYLNES-K----AMQK--ALALRFKALVTTEYLTGRKL-FRILASI-DTCTMNLIKIQVEIAMLLLM---IIANAKR------TuGR13/1-400 ------MA------SGIESF------VSKSFPFSRFLIKKRFFWLT-YL-NLRSPW------YNRAITIL---LCCLCTSYLIRAPIYIFAP------IEPIRKLYLGDFAYNYES-IH---DVIWAVQAFWFLSA--IYAIYIID--ETNRSVKMQIWF------DGLS------ILEEGK------DEFFRRPNGKI-IVAS---KLYYSNVDSSVI------FALLFNYSFFLPN----MI------LH----HS------DTPLL-I----LLNIHSLII------SGAATAATNYGINICFLFCFNAFLVGQKFIKL------KERF-DTKMDKT------KRWHR------K-ISS-----N-SARFISLLKQVYYGNFFWSQICSAAFSSTFIGQIFLMYLLFFIPLNK------FHFFS-LLGLAIINFACGQSLIFLSGVY-----AKSKLNDCHKQL-RRVIYS-K----DIKL--RVVDKMKLTIISEYVSHRKL-FVILASL-EMNSYNYLLVCIEMISHLLL---VIINKKYRSSSLYES------TuGR11/1-394 ------ME------STSESR------NSRSFSLSYFLIKSQFFWQS-YL-PLPIPW------YNQLISTF---SCFICLTFFIRAAIYNYVP------LEPVSALYMGDYAYNFGS-IH---DIIWFIHLFWYTAT--VFAFNLLN--KSNRSVKLQTWF------TCLT------ILDQGK------DDFFVKPNEAL-ILAS---KLLFISAKSSLL------FGLPFTFSLFIPH----MI------NN----YS------NAFLF-L----MVSIHGLII------VVAGFAAIAFCVNMSYLFSFYAFLIGQKLTKI------AKTF-KSQMDSK------SIFSHR------K-ISS-----N-SSRLIRLLKQVYCANFFWSKFNSNVFINTFFPQILILYSIFFVPLNK------IHLIA-LFGLGSLNFACGQSINFISGAY-----ARSKLNHCQRQL-RRVIFT-N----GCKL--KITHKMKLLIISEYLLHRKL-FAVFESL-EMNSFNYSLVFIEMAAHLML---VIVNANRK------TuGR12/1-395 ------ME------PLSDSH------PKQTFLLSNFLIRKQFFWLK-YL-PLPIPW------YNRIVLTF---GSLVHLSFLIRIYIYNFVP------LDPLLALSIGDFAYDLVP-IH---NIIWFVHAFWWAGS--VFTFHLLN--KTNNSVKMQTWF------TCLS------ILEDGK------DDFFDKPNDKL-VHVS---KLYFFNAKSTLL------AGPTFSFCMFIPH----MI------NH----YS------NVPLL-I----VIVIHALIT------TVAAFTTVVLCVTMCYLFGFYAFLVGQKLHQI------AETF-KTQIDQV------IKSNR------K-ILA-----N-SSRFLGLLKEAHYASYFWSKLNSCAFINTFFPQILILYSVCFVPLNK------IHFIC-LVGLGTLNFACGLSVNFLGGAY-----ARLKLNHCQKQL-LRVIIL-K----GDKL--KLNHKLKLLTTSEYLLNRKL-FAMFASL-EMNSFNYLMVFIEMAAHLML---VIVNANRKCC------TuGR16/1-389 ------ME------SGRSFI------VSTRYSLSYYLVKYQLYWLS-YL-PLPIPW------YNKTVSVF---CYFVCLVYLMRVIIYIFVP------LEPPLALYLGDFAYDSDS-LH---DFIWSILSCWLTAS--VFAFHLLD--QTNRSVKLQAWF------VHLS------ILEKGK------DHFFKKPNKKL-VFAS---KLLFINLKTTLL------CCPSFAFCLFIPH----VI------NN----CS------NIPLV-I----VLLVHGLTT------FIAALTGVTFCVSLSYLFAFYAFLVGQKLTYI------SEVF-KCHK------SSHR------K-ILS-----N-SNQLISLLQQAYCADFFWSKLNAYVFLATFFAQIFIIYSVFFIPLDK------IHFIC-LIGLGLINFTCGQSVNFVCGVY-----ARSKLNDCQKQL-IRVIFI-K----DAKL--RVSLKIKLLIISEYLLPRKL-FAIFGSL-EMTSINYLKVFTEMAIHLFL---VILNANRK------TuGR14/1-394 ------ME------STREFQG------ISKRFSLSYYLIKKQLYWLS-YL-PLPIPW------YNKPVSIF---FYLISFTFLSRLIIFIFVP------LEPLLALYLGDFAYNLDS-LH---DIICSMVSFWLAAI--LTSFHLLD--ETNKSVKLQAWL------TPLS------TLEKGK------DHFFKKPNKKL-VFAA---KLLFTNLKTSLV------CCPSFVFCLYIPH----MI------TN----YA------NGQLV-I----VLLVHGVTI------AMAGFMGICYIVSLSYFFAFYAFLIGQKLSYI------AEIF-KTQIERT------TKSYR------K-IVS-----N-SDQLISLVKQVYCADLFWSKVNSIVFFATFFPQILIVYSVFFVPLNA------VHFIS-LIGLGSINFTCGLSVNFFCGVH-----ARSKLNDCQKQL-IRTIFI-K----DAKL--RVPFKIKLLIISEYLFPRKL-FAIFGAL-EMNSLNYLLVFIEMAIHLLL---VILNANRK------TuGR15/1-386 ------ME------SKRYTLSYYLIKRQLYWIS-YL-PLPIPW------YNKPVSTF---CCFVSFICLSRLIIFILVP------LEPTLALYLGDFAYNLDS-LH---DIICSMVSFWLVAI--LISFHLLD--QTNRSVKLQAWF------FRLS------ILDKGK------DHFFKKPNNKL-AFAS---KLLFINLKTSLV------CCPSFAFCLYIPH----II------NN----YS------NATLV-I----VLLVHGLIL------VMAAFMGICFIASFGYLFAFYAFLIGQKLRYI------TRVF-KFQIEQT------TKSYR------K-IVS-----N-SDHLVSLVKQVYCADLFWSKANSIVFFATFFPQILIVYSVFFVPLNA------VHFIS-LIGLGSINFTCGLSVNFVCGVH-----ARSKLNDCQKQL-IRVIFI-K----DAKL--RVPLKIKLLIISEYLLPRKL-FAIFGAL-EMNSLNYLLVFIEMAIHLLL---VILNANRK------TuGR17/1-396 ------MDK------LK------YPKTRVKLSKYFTKYSFLWLT-YL-ALPSPW------YNRLISWL---GLLSLISFTVRIYLFTNYE------LEPVVALYLGDYAINFGQ-SH---DLLLFLDLCWILCA--LIGWILIH--QSNTSIHKQTWF------HSLA------ILDGTV------DHPKRFQCTSESAV-GLAS---TILFICMKSSLI------AGSVFAWCFYLPH----FI------AN----FN------CFSLF-I----NLVRDSLLA------SASAFYTNACCVNFGYLFSFYAFLTGQRIDYI------VRSL-KQQSMKS------HSSRR------I-VFS-----N-ANDVISILKQVDQTSSFWSPLNSITFIFTFIASILILYLVFFVTLDN------ITRIT-LIALGIINFACGQSINLLSGTY-----ARLKLDQCHKQL-YSLLTS-T------QF--KLNHKVKLFVIAEYLVNRKL-FAIFAVL-EMNSLNYLLVAIEMASHLLL---VIINANRNSKII------TuGR21/1-381 ------M------KRM------MK------NSLTNYLNKYCLLKLT-YL-PVQSAW------YYAFIRTS---VLILLIVITIKGIVLMIFK------FDHSTALAWGDYAVNWLK-PH---QFLLGINNLWFFCG--WCAVTLLQ--RTNVSPKKQFWF------HSLS------ILDEYI------YDWTKETKSII-IY------LFFSVLKSNLF------LGAAFSWCLYIPV----LI------ESE------SIFQF-F----HLNLAALNA------AIAGFCCTAFCVNFSFIFAFYSLNSGFKYHKL------ASRL-SRQVSRP------SSSS------T-INK-----M-NRDLIELLIENYKSNSFWTQMNSTVFLGTFLAQIPILYLIFFVPLTN------FIKFS-MVILGALNFLCGQSITFLSGSF-----AKAKFDECRKQL-NLILIN-RD-----DL--RLYHRIKLLCSADYLINHQL-FYIFGHF-EFTRVNYLLVILEIISHLLL---LIANAGIN------TuGR23/1-378 ------M------AR------NSFTNYLNKFSLLKLN-YL-AVQSPW------YFVFFRVT---VIFLQTLITIRFIIFVTVK------LEYSTALNSGDYAVNWPK-PH---HFLIIINILWFFCY--WSSLFLCQ--RTNISPKKRFWF------HALA------ILDDDI------SDWNKESKSTV-IY------FFFHILKANLL------VGSLFSWCLYIPV----LI------ESE------SFGQF-I----LISLSGFNG------AVAGYCSTSFCVNFSFIFAFYSFNTGLKYERI------ASRL-SGQVSTR------SHSS------I-LDT-----I-KDDLVRLLIENHKANYFWTQLNSTIFLLTFIAQIPILYLIFFVPLTT------FTKCS-MVMLGMLNFLCGQSITLLSGSF-----VKTKFNECHKQF-NRVLIN-RI-----DL--DLYHKIHLICSAEYLIDRQL-FYIFGKF-EFNNINYLLVVLEMISLLLL---LIANAGSS------TuGR22/1-384 ------M------KLV------ME------QSGQSLSNYLNKFSLLNLH-YL-PTQTSW------NCFLFQIF---SLFFLVMALFKGFIFILEP------FSPSTALLLGDYAINLGA-PH---HFLHSINLLWLLCG--FICFNLIQ--STNVSPKKQFWF------HSLS------ILEGDV------PDWTRGTKAVV-IY------LFFHNLKSNLI------LGGAFSWCLYIPV----LI------ESN------STEQF-F----FLNLSGFNG------AIAGYCCTAFCVNFSFIFAFYSVTTALKYDKI------ASRL-RRQVSTL------SDPT------I-IDS-----I-NHDLIQLLIENHKANYFWTQLNSTIFLLTFIAQIPILYLIFFVPLTN------FTKFS-MVILGALNFLCGQSITFLSGSF-----AKTKLDKCHKQL-NRLLIS-RD-----DL--TFYHRIQLICSADYLINRHL-FYIFGQF-EFTHINYLLVIMEIISHLLL---LIANAGAG------TuGR24/1-384 ------M------VKM------IQ------NSLTNYLTKFSLLNLD-YL-TAPSPK------YYTFIRSF---SILNLIVLNTKFIIFITVK------LDHKTALNLGDYAIKWSK-PH---HFLLFVDILWLTCG--LSTIYLLQ--RTNVWPKKQFWF------KYLS------ILDADI------SDWTYGNKAFI-IN------LFFCVLKSNLF------LGAAFTWCLYIPV----LS------EVE------SIKQF-F----FISLNSFNG------AITGYSCTALCVNLSFIFAFYSLSTGLKYDNL------ASRL-KSQAAAP------SDSK------I-TNI-----I-NRELIQLLIENHKANYFWTQLNSIVFLCTFFALIPILFLIFFVPLTN------FIKFS-MIVLGALNFLCGQSITFLSGSF-----AKTKFDRCFKQL-NRVLIS-RD-----DF--NFNNRIQLICSADYLINRHL-FYIFGGF-EFSQISYLLVILEITSLLLL---LIANAGLVDRH------TuGR25/1-384 ------M------MKM------IQ------NSLTNYLTKFSLLNLD-YL-TAKPPK------YYLFIRIF---AIFNFIVVDTKFIIFITVK------LDHRTALNLGDYAIKWSK-PH---HFLLFINILWLTCG--LYTIYLFQ--RTNISPKKQFWV------QYLS------ILDADI------SDWKYNTKSFV-IK------LFFCVLKSNLF------LGAAFSWGLYIPV----LS------EVE------SIKQF-F----FISLNSFNG------AIAGYSCTALCVNLSFIFAFYSLSTGLKYSNL------ASRL-KEQTSTL------SEPK------I-TNT-----I-NRELIQLLIENHKANYFWTQLNSIVFLCTFFPLIPILYLIFFVPLTN------FIKFS-MIVLGALNFLCGQSITFLSGSF-----AKTKFDRCFKQL-NRVLIS-RD-----DF--NFNNRIQLICSADYLINRHL-FYIFGGF-EFSQISYLLVILEITSLLLL---LIANAGLVDRH------TuGR26/1-386 ------MSI------TANPTKM------MR------NSLTNYLRKFSLLKLD-YL-TVQSPK------YYLFIRAF---AIFNLIALNTKFIIFITVK------LDHKTALNFGDYAINWSK-PH---HFLLFINILWITCG--LSSFYLFQ--RTNDAPKKQFWV------QYLS------ILDADI------SDWKHSTKSII-IY------LFFFTLKCNLF------LGAAFSWVLYIPV----LS------ESA------SLKQL-F----FISLGSYNG------AVAGYCCTSICVNFSFIFAFYSLTTGLRYDKL------ASRF-AKQASTL------SDPT------I-VDT-----I-NKELIQLLIENHKANYFWTQLNSIVFLLTFFALIPILYLIFFVPLTN------FVNFA-MVILGALNFLCGQSITFLSGSF-----AKTKFDRCYKQL-NRVLIS-RD-----DF--NFNHRIQLICSADYLINRHL-FYIFGGF-EFSQMSYLLVILEIISLLLL---LLANAGR------TuGR29/1-403 ------M------GKV------ISQS------KVKRK------KIKKLKT------KMEKS------RQFSKLSAYFEKQLLIHFN-YI-PVNHSK------RRQLVSYI---ALIIFISVTIKTIVFTLLP------ADNPILYYLGDATIEFGA-IR---TPLDCMLSIWTLGG--LYCGLFLK--YTNQSVKHQHWV------RVNQ------LLNTKSPAE------MKV-IK------LFLHQTQSNLI------LAFLVTVGLNIPL----LF------QCPPGFYS------LNIVYLGLH------GVAGFLVSAYAINFAFFFGLDMFFVARRFKSY------YRSL-KT-LVRY-KA------ISDFKRD-----TLIRR-----S-VRHITSQLKQIIETYHFWEKLNHACFISSFINQSLILYLVFCSPTRQ------DLKIV-LSVYGLLNCATGQSLHFISANY-----AQKQIDHAISQL-HNANTK------TS--QIKTKLENLNFLEYVDQRKY-FTIFGSL-EYSSKNLVTVTIENAATLLL---LVTNLGYRQIF------TuGR535/1-407 ------M------A------TLIDM------KEIG------K--PHE------NLYEYFNNY-LAKQLIHLN-YL-PVNVSK------S------SFLVLTCSL---SLFIYFGAILKEFWLLFSD-----PSDDPIFYKLGAPTVSLGFIFH---REISLILLLWLSGT--LYCALFIK--YTQYSKKHQSWI------QSFV------YLSPKASVS------SLDKL-IR-----KSFLLQTRIVLV------FSVAGIALFQMIT----LS------RC------PTSLI-A----YCLFNYILN------IFNAFLTAVYLGSTGCMFTFHCMMLGVTFNRL------AKRV-DK-MINY-LA------INKQTAK-----H-INV-----Y-LHRVTKELRHLNGSKVFWEHLNSTIFLSTYLAQSVLLYLLFFVSVPF------LMKCS-FFLMAIVNFLGGQSIHFIAGHI-----AKVQIEKCLFQL-NRLMFR------RI--PGPSKIKIIQVLEHTRGGKF-NTIFSAV-EYSLASLIMVTSENAVLFML---LIVNYSRRSFNVTQL------VEEIG TuGR30/1-410 ------M------VIQ------NFKDPTVF-----MERDTFLSKF-LRKLSIQLN-YI-PGGSTK------IRK----IFGFLSWL---GVVEVALLCSRDSVLIFLD------DDSDYIYIFGDFAAPAGK-FR---KQATLIFLLYLYGS--LYSAIYLV--RTQKSPKYQVWI------KMFK------AYDNRSWLN------QKAELH-----RLYWLTTRIELIYSI---SITISLIFLSAVL----TI------TF------PPRFI-----HYTLAHQLLN------IHGGYNSCSYWGISYLLFPSYGYLLGQRLDKI------SHNL-NKCLEQI-NSNYCVR------HQIKST---TIRIGN-IKSVTPRKL-INQLTKQLKQLHNACLFWSRISEPTFLISFINQALLLYLIFFVPMST------GFRCF-LAVLGIFNFISGQCCHFFAGIY-----TQKKIDNCIKTA-LKLGYS------QI--DWRTRFTVLSVLEAVQERKF-FTIFNAI-EFCSEHYCLVLLEGVSLLML---MIATYGSRN------TuGR18/1-385 ------M------NRYPGFRRY-LNYQLVDLT-YL-VTDESK------SFKLFFPL---SFAVCLTNMIKQLINLSQS------EVTSLSYYLGDLTLVVGA-TR---KHLTLIYFGWFSAA--FTCSLALY--VSQFKPSLQKWV------SIGV------IFDQFG-ST--KVHPHSGL------PTI-VHK-----YFIKLSHISYI------LGGLAAFLCGTPS----LF------IY------PSQFI-I----YLVFWLLIT------AVGGLVVLGNAANFGPLFGFSVYLFGKHLTSE------KDNL----IVET------KSYEKGEDW---NT-IVA----NS-MRSSTNQLKGLIESYQFWILVNQFLFLATYLAQFILLYLIFFVEVHK------FLRIS-LIAFGVINFISGLSVHFWLGAY-----GQHKINQYCSQL-RRALFT------NG--SIDMKLNIIIYLEHVETRYF-FTIFGAL-RYSFFHFILVICENITNLLL---LIASLAGGMGH------TuGR19/1-384 ------M------DELPGFHRY-LKYQFNSLN-YL-QTSESV------QIKWFFPT---TFIVITVSLIKQLINLSLS------EVNSFSYYIGDITLVAGH-TR---KHLTLIYFAWFFGG--FGTVLTLY--RSQFDRSLQKWA------RIGV------IFEHLD-ST--QIHPYSGL------PTI-VHR-----IFIHFCNGALI------GAALASFLCVLPS----FL------IY------PTKYL-I----YLIFWLILT------VAAGSSVVCNGANFLLLFTASAYIFGRRVHEE------TLILVDK------VAEKCESFQPLNS-IIK----HS-VKRLTLILIHQIEEYKFWVILNQNGFLSTYNAQFILNYLIFFIDIPK------FLRIS-LIIFTFINLAVGLSFNFLVCTY-----AQHKIHGYCSNL-RQTLNE------NI--SIRTKLRTLIFLENVENRYF-FVIFGAL-NYSTHHFIIILLENITNLLL---LIASLRRQN------TuGR20/1-428 ------M------D--EQDLV------DESSHSE------QIS------SMD----SITED------PEIMEQTEF------ESYPAFRKY-FNRQMVDID-YL-VYPKKP------KIWYFCF----GLTFLVITGLRAAWQASYT------QLSVFSYYIGDISLAAGDAIR---KQLASIYFIWITGS--AILAVNLY--KTQREPSLQHWA------KSIG------QVFQHYS-TTHHPIYPGLP------YKL-IK------MFAIFNQINFY------SGGSLALLCSLPT----LY------VY------PPEYT-I----YAVSWLPFN------VFTGLFCGAYVINFTSLYFLFVYIFAQQMDKM------FASF-TS-IWTI-ASPSPP------SSDS---LSISGS-IIK-----F-QSCLLDILQQLNNSNRFWFFLNNIIFLVTFCVQSMLLYIIFFVKVPS------FLLAA-LIGYAILNFSCGQSFHFIFGAY-----GQRKIDQHLHKL-KQSLYL------DS--TINAKIKSITFLEHMENRHF-FSVFGSL-NYSTHHLVLAILESATNLLL---IITSLGRARTFMKI------TuGR27/1-412 ------M------VSLS------RILHQ------NRLLR------ATKYHKTMDAL-FRSQLLYSP-YL-DVPFNL------KMFLISTL---SLFNLTVVTAKCLVLYDTE------SYSDLNFLMGDPTFHLEE-AR---SFLLLLLFDWLAGC--ILQYSIFLVQLAGSSTDKYIWL------CIGE------VLKTGQ-YK------NWGSF-----HTI-VK------LFYRQIKLNCY-----ALAVGFLFLANLPA----VI------SA------PRRFI-L----PMFIHALLH------SWAAFIASSTTVNFIMLYALYVHVWSNYLTHL------SSEL-AK-ILIP-EKYLLNQH-NFSLD------SIRLPSR------Q-IRL-----T-LIHLTDHYQEFIQSYRFYGLRNGLMFMCTFFANTFVMFLVFFTPMPS------LYKLA-IVLCGIFATLCGQIIQFYSGIY-----GQSRSDQAMRII-RKILYT------KS--SSRSRLIVLLFSDHFVERHF-FTIYGSL-QQSSKNLILTIAESSTLLLL---LITNIGRRINYS------TuGR28/1-414 ------M------VSLS------RFLKRYR----KKRIE------KYLPTMDQL-FSSQLIYSN-YI-ASKPSR------FMAFISYA---TFINLISVVIKCWILYFLP------PFSPINFYLGDPGFILGS-AR---KTMTILLSIWCLGS--VIQHLHFI--LNSGDRGDHNWL------LIGQ------VLATNR-YK----KIGVD------PNI-VK------SFYRQVQLNCY-----LVTLAFLLFANVPS----AL------LA------PPQFR-L----PMMINAITH------SWGCFAIVSYSVNFVLIYGLFVHVWLDYLELL------NDRL-IK-IMTM-EVKKKSNE-PDLLDHCA--TTIQLNEQ------K-LKI-----L-LIHMTDHYQELIACDKFYKIKHTLIFSYGFIAQGMVIFLLFFNQFSI------MYKIA-LFICGIFNSIFFQYLQFFIGIH-----GQSKINRALRNL-HKVLYI------SA--LPKTKLTLLMFIDHFVDRHF-FTIFGSL-QYSTHNLILALLELASLLLL---LLTNYARSQKNY------TuGR64/1-433 ------M------VESN------LKKLFTVN------VW------ANLLR------LVN-LQ------NNSEI------ETVEAIRSF--DKIFRRWS-SC-RGGLQQ---TLDK------PINI----KFHIYNWF---FRFNVFIIISRFIVFIL-I------DNYYCDLCLANPFGETKG-AK-KNALMLCIIFISMFLY--GFRDYPL---QLEETGRMKV-I------RILY------LLEKRG-FN--AEILNMSNLRCEQF-----RKW-CD------TILVGIFFAII------TLQMIALFFLIYL----RISLVYSNGSQFII-PR------TLLHY-I----FHLIFIIIE------IFTFFVFVINAMCTSAYILVILTFFILRLNTL------IDLI-KR-LSLK-SS------LNNS------I-LSE-----L-NYRLIEVLNDFGQWNGDSKYLFQYAIIASSAIANFFCFVGFLYDLEPD------ATTMS-ISIVGIFVHILVSIGCYLGAEF------HYESIKMRKLF-CNLYCKLT------KN-ATTQVRLKSMEIVDRLDSRCIGAHVGDFG-ILYRSTCIIVLLENASFIML---LSCNVR------TuGR63/1-430 ------M------TEATD------IKRFLVVY------MK------ENVSK------LID-LQ------NSFAI------ETAKAIHTF--DKVFGLWL-SR-RGGLQQ---TLDK------PIKV----KFHIYNWF---YRFLITILIIRLTVVIL-V------DNYYCDLYLANPFSGSKE-AK-KNAMMLYLALLTMLLY--CVREYTL---RLEETGRMKI-T------RLLY------ICERRG-FN--AKVLNVNNYRCKQF-----QKR-CH------AILISIFMFMI------GLNIISLFSITYL----RT------SQLPV-YP------TLIHL-I----FHIIFMITE------FITFALLIINCMCTSAYILIFLTFYIKRFNTQ------IDWI-QK-LSSK-SS------LNNS------I-LSD-----L-NYRLIEVLNDFGQWNDDTKYLFQYCIIAPSAFANFCCFVGFVYGFEPD------GLTMT-MSIIGIFVHILVTIGCYLGSEF------HYESTKMRNLL-CNLYCKLT------AN-ASTEVRLKSMEILDRLASRVIGAHAGDFG-IFYRSTCVIVFLENASFIML---LSCNARSFI------TuGR65/1-441 M------LTAFKKTIASIIEKM------AKSND------KKRFSIVN------IK------ENVCR------LQN-LK------NHFEI------ETAEAIHAF--DKVFSLWS-SL-RGGLQQ---TLDK------PINI----KFNIYNWF---VRCYVAILIARFTIFIF-V------DNYYCDLYLANPFSGNKG-DK-KNAIILFIIFLLMFLY--GVRDYTL---RLEETGRMKI-T------RLLY------ICERRG-FN--SKALSMNNHHCKQF-----QKW-CH------TILISIFMFMI------SANIIALFTIIYL----RT------SSFIV-YP------TLTHI-I----FHIVFIITE------FFTFSVLIVNVLCTSAYILIFLTFYTIRFNTF------TDSI-KK-LNLK-SS------INNV------I-ISE-----M-NYRLIELLNDFGQWNYDSKYLFQYCIIASSAVANFCCFVGFLSGLEPD------ATTMT-MSIVGVFVHILVTIGCYLGSQI------YYESIKIRTYI-CKLTTK-T------TVEVKLKSMEIVDRLDSQYVGVHMGDFG-IFHRSTCIILLLENASFIML---LSVNARSFI------TuGR66/1-431 M------QKLKSKVDT-M------VE------RIRFFIVN------IE------ENLFR------LVG-RR------NSSEI------VTAKAINLY--DKLFGLFV-SR-RGGLQQ---TLDQ------PIKI----KFHAMNWF---TRFLILFFIVRLCLGIF-V------RNDYVGLLMANPFS-NKD-DK-KNAILLFILFLITYIY--GIREFTL---RLEETGRIKM-I------RMFS------MLEKQG-FN--TKALNMNFNRCKQF-----QKW-CH------LIFVNNLMNII------CLNSMSLFLIIYL----RA------SQR------TSSLF-M----IHIIHMVIE------WITVCLLIINVMCSTSYIIVMVTFFIGQLNTL------TDSI-KN-LALN-SS------LSNS------I-SFK-----L-NYRLIELLNHIGQWNDDWKYLFQYCILAASFLGNFTCFAGFLHGFQPD------ATTRT-MTVVGIFVHILIYIGSYLGSLI------HSEAIKIRRCY-CKLMST-T------KN-HEMHFRLKSMEILDRLDSHLIGAHLGDFG-IIKQSTCIILLLENASFIML---LSCNIRSFI------TuGR67/1-423 ------M------AE------KVRFFIEN------IK------ENLLW------LID-PE------NISEI------GTIKVIHLF--EKLFSLFV-SR-RGGLQQ---TLEQ------PIKI----KFHVINWL---TRFLSLFFMVRLCLFIF-T------HNSYLDLFLGNPFS-NKD-GK-QNAVLLHIFFMCAYVY--GLREYTL---RLEETGRLKI-I------RIIL------MLEERG-FN--AEELNMNYHRCKQF-----QKW-CH------YIFTYNFMSII------CSSSLVILIDIYS----RC------SQATY------QLSFI-I----VQVIHVFVE------GITLFLIAINGICSTTYVLVIFIFFIRRFNTF------NDSL-AK-LNLR-SS------MNDS------I-LTK-----L-NYQLTELLNNIGQWNSDFKYLFQYCVIASSFISNFACFVGFLYGFSPG------AMTRT-VAIFGISHHMLVFIGTYLASTI------HSESIKIRRCY-CKLLSK-G------KL-NEMIFQLKSIEILDRLDSNTIGIHLGDFG-IVKRSNCIILLLENASFLML---LSCNVRSFN------TuGR68/1-423 ------M------AG------RVRFNTVN------LK------QNLLL------LMD-PE------NTSGI------GTIKVIHLY--DKLFSLFV-SR-RGGLQQ---TLDQ------PIKT----KFHVINWL---TRFLILFLLFRLCLGIL-T------NNYYHDLFLGNPFS-NKD-GK-QTAVLMYIFFMCAFVY--GFREYIL---RLEETGRLKI-I------RILL------MATERG-FN--AELLNMNYHRCKQF-----QKW-CH------YIFISSFVTIV------CSSNMVIFISIYL----RG------SQATY------QVSFI-M----VHMIYVFVE------WITFLLIAISGLCLTCYLLVIFTFFIRRFNTF------NDSL-AK-LDLR-SS------MNDS------I-LSK-----L-NYQLIELLNDIGQWNNDTKYLLQYCIIVSSIISNFACYVGFLYGFSPG------TITRT-VTTFGLVHHMLVFIVAYLTSLI------HSESIKSQRFY-CKLLSK-M------KV-HRLKFQLKSMEILDRLDSNLIGIHFGNFG-IIRRSTCIIILLENASFLML---LSCNVRSFN------TuGR69/1-457 MMRNE-TIYQFEDE------FHLDLNNRSKASIYTMM------RSTN------DKNFFSFN------IK------KSLTR------LKG-LK------NVSEI------KTAKAIHLY--DKMFSLLA-SR-RGGLQQ---TLDQ------PIKI----KFHILNWL---LRILVLVLMTRLIVLIA-V------EKYDCDLYLANPFSGSKG-AK-KNAMLLFILLESVYIY--GLREYTL---LLEETGRMRI-I------RILF------MLEKRG-FN--PGMLKMNNHRSKQF-----QKY-CY------SILINILINTI------TLTIVMLFIIIYL----RT------FHLTV-HS------TLMHS-M----FHIIYMFTE------FITFFVLIISAMCSAAYLMVMMSFYIGRFNTI------TDTM-HQ-LNTN-NS------VSCT------I-LSE-----L-NYRLIDLLNDFGQWNDDTKFLFQYCVLFTSAYADFDFFIGLLYGLEPD------GSTMA-VTIIAISSHLLLFICSYFASQF------YHKSIEIHRCY-CILMSK-T------KL-HKGQIGLKSMEILDRLDSKSIGVHMGNFG-IFQRSLSLTLLLENASFIML---LSCNVRLLI------TuGR70/1-453 M-----TIFEIHLKSIAFR------LSAKIFCYVEAAIFAMM------QSCSVDK------IN------KNLSK------LIG-LQ------NESKI------STTKAIHLW--DKLFRAVV-SR-RNGLRQ---TLNI------SIKL----EAHFRNWF---FRFFIVILIVRLNLFIF-Y------DNYYSDLYLANPFNGIKG-AK-KNTMLLTVIFLSAIYF--VLREYML---RLEETGRMKI-I------RMMI------KLERTG-FN--AASLKMNHLRCKQF-----HKW-LH------FVAVNGIRIIT------LFTIIIIFGIIYL----RT------SQPQE-GL------TLQHY-A----FDVIFMPFE------FIALFVLANSAMFSFIYIILLVVFFIGRSNTL------TDYC-KK-LIMN-RT------LRCS------K-FSQ-----M-NYEMIGFLNDFSQFNNETKYLFQYAIFSVSAFGNFACFFGFIFDFEPD------AITRI-LTIGGIVSHTAIFISCYLGGFF------YQESIKVYKYY-CQLMSK-T------KN-HKQEVKLKAMEILDRLDSKFIGAHIGDFG-IFKPVTCINLLLENACFIML---LSCNIRAFI------TuGR71/1-438 M------VNFFIYLRAAIFALM------QSYFVDK------IK------KNLLK------LVG-LQ------NESKI------STTKAIHLW--DKLFRAVV-SR-RNGLRQ---TLNI------SIKL----KAHFQNWF---IRFLIVILIVRLMLFIF-F------DNYYSNLYLANPLNGSKG-AK-KNTMLLFIIFLSVIYF--VLREYIL---RLEETGRIKR-I------RVLL------ELESNS-FN--AESFKMNQLRFKQF-----HKW-FH------FVAVNGIRITI------LCTFIILFGIIYL----RA------SQPQE-CL------TLQHY-K----FDVIFMPFE------FIALFALINSALCQLVYIILLIIFFIGRSNTL------TDYC-KK-LIMN-RP------LSCS------I-LSQ-----M-NDKMIDFLNDFSQFNDESKYLFQYAIFSVSAFGNFAIFFGFIFEFEPD------VTTRI-MAISGFLSHILIFIYCYLGAFF------FQESIKVYTYY-CQLMSK-T------KY-HKHEVKLKAIEILDRLDSKYIGAHIGDFG-IFKRSTCINLLLENACFIML---LSCNIRAFI------TuGR72/1-432 ------MMRGAIVAAM------RTFSIDK------MN------KNLLR------QIG-LR------NDFKS------ETIKVIHLY--DKLFQVVV-SR-RNGLRQ---TLDM------PIKL----KVHIQNWF---IRFLIAILIVRLIVFIC-V------DNYYTDLYLANLLSGSKG-AK-KSIMLIFMVFLTAICL--VLREYIL---RLEETGRMKR-I------RVLL------ELESKS-FN--AESFKMNKLQFKLF-----HKW-TH------FVLVNGMRIIF------LTTMIILFAIIYL----HT------SRPQE-YS------TLQHY-T----FDIIFITLE------LIALFVMANNAVATYIYIMLLVVFFIGRSNTL------TDYC-EK-LHIN-RS------VNCS------K-LSQ-----L-NYKLIEFLNDFSQFDDEFKYLFQYTIFSVSAFGNFACFFGCIFEFEPD------ATTRI-MAICGFLSHILIFICCYLGAFF------YQESIEIHKYY-CSLMLK-T------KF-QKYEVKLKTMEILDRLDSEFIGGHIGDFG-IIKRSTCINLLLENASFIML---LSCNARAFI------TuGR73/1-417 ------M------LDFGKA------VK------NFLFR------TIG-L------P---DESDI------ITCKALIQF--NRLSKIFIPSA-RIEHEG---NKD------ELRR----KIRLENLF---LRTCIIFTIFRINVSLF-V------DNYYIDLFLANPFSGNKS-TK-GFFFLIQVDLVFICLF--VLREYCL---HLEETGRFKV-F------RVFH------HISKNG-LS--RVSLGLSYRQCKKF-----HKT-IH------NMMFHSIRIIL------ITTILMTISVMAL----KV------HNFSS------TFIHL-I----FILVYTPIE------CVSAIPMFVNVMCYTMYCGSYLALNLSRFNTL------QEII-KK-NSLT-IS------YNCT------A-LRL-----M-NNRVVYFLNHFDRIDSYWKYLFQCYFIVV-LPADFGLFFAIILDFDSD------ILSLI-TALNSIIVHIAVIASYYWFSHF------YHETIDMHKRY-VSIILH-SG-----SA--SLVDKLKALEILDRTGSPHIGVSIGDFC-RLKRSTCIFYLLENASFLML---LTCNIRV------TuGR74/1-425 ------M------TKLR------MVDFGKA------IR------NFLFR------TIG-L------P---DESDM------TTRKALIRF--DKATKFFLTSL-RNGYEQ---NDG------KLVL----KIRLRNIF---LRSAIIFTIIRTTVFLF-V------DNYYFDLFLANPFSRNKS-TK-SFLFLILMDLICIWLF--TLREYCL---HVEETGRFKV-F------RVFY------QIAKNG-LD--PVKLGLSHRQCKKF-----HRK-MH------FLMIHGYRMIL------ITSVLIFVASTAL----KV------LNFSS-YL------TAVHL-I----FLVAHIPIE------CFSILTVSASGISFFINFGSYLALNLSRFNTL------TEII-KK-NSVV-IS------SNST------A-FRN-----M-NNRVVYFLNHFDKIDTHWKYLLQYYFFMISLTADFGFFVAVILDFGSD------IVTKI-LAFYSIVGHFSGMMGYYLFANF------YHETIDLHKRY-VSIILN-AD-----SA--SRVDKLKALGILERTGGPHKGVSIGDFC-RLKRSTCIRYLLENASFLLL---LRCNIRS------TuGR75/1-422 ------M------HKFNNK------LR------KYAFK------VIG-L------PI--GSSDY------PTRKVLLHF--NKICNFFLTSL-RNGHEQ---DENH------QQRL----RVRMQNIF---LRSTIIFTIVRITLGMS-V------ENYYFDLFLANPFSGNKS-MK-VFLFLFLMDLAFICLF--LLREYCL---HLEGIGRFQI-F------KVFH------RIQRQG-FN--HTQLGLSYKQCKLF-----HKI-LH------FMMVNSIRIIS------NTIILLLLSTIGL----KV------LNFAS-FS------TAAHF-V----FLLVHLPIE------CVSIFTVSVNFTSLVTNFGSYVALESRRFNTL------IELI-DE-NIVT-IS------SDSA------A-FRK-----M-NRRVVYVFNHFDRLDSDFKYLLQYFFIMVSVAADFSFFVAIILDFDSD------IVTQT-VAFNSIIIQITNIIAYYLFAHF------YQKTIDMHKRY-VSMLLN-AG-----SA--SLVDKLKALEILDRTGSPYVGLSIGDFC-RLKRSTCIFYILENASFLML---LTCNIRA------TuGR76/1-432 ------M------SESS------KKLK------ISYFVHY------CK------SCSYK------LLA-WT------GESDY------ETRKALERF--DNLNKLMFISL-RGGQKQ---EYDK------PINL----KLWIGNWI---IRIAILLTFIRLNLFLYFD------ESDQLDLYLANPFPDSRR-QK-STFMAILGVVTIVIFS--LLREYYH---YIERAGILIA-L------RIFF------TIRNRG-IY--WKPLKFNERSAQFC-----NKI-VY------LIMAQGARLMV------FVWFYSAALVFIL----HL------SYPAA-YS------SGVHI-F----FILCIIPSE------IVTFGLLFNGLVSLGIYLWTFIAVFNAQLEAI------RDEI-KN-CLRR-CS------LSPA------G-LSR-----I-NEKMIQFMNEIEETYRRLDYLHLYLMGLIALQADVMLLFSLIFKLFPN------FISSL-VTFGGILIHFFLVIGNLWASSY------YTKTLSIHGHY-TGLILN-T------KA--NCSARFKALEVQDRINARQTGVAIGNLC-LITPSFSLLFILENINFIML---LTVNIRTLV------TuGR77/1-432 ------M------IENS------KKLK------ISDFVQY------CK------SYSYK------LLA-WT------GESDC------ATRKALEHF--DNLNKLMFISL-RGGQKQ---EYDK------PITW----KLWIGNWI---VRITILLTFIRLNLFLYFD------ESVQFDLYLANPFPDSKR-QK-STFMLILGVITIVIFS--LLREYYH---YIERAGILIT-L------RIFF------NIRNHG-IY--WKPLKFNARSAQFA-----NQI-VH------LIITQGARLMV------FVWFYSAALVFIL----HL------SYPAS-YS------SRVHI-F----FILCIFPSE------IVTFALLFNGLVSLGIYLWTFIAVFNAQLEAI------RDEI-KN-CLRR-CS------LSPV------E-LRR-----I-NERVILFMNEIEQTYCRLDYLHLYLMGLIALQADIMLLFSLIFKLFPN------FISSL-VTFGGILIHFFLVIFNLWASSY------YTKTLSMHGRY-TGLILN-T------KA--NCSARFKALEVQNRINARQTGIAIGNLC-LITPSFSLLFILENINFIML---LTVNIRTLV------TuGR78/1-453 M------FDFSLMK------LKFSI--HYSMKLLP-K------IENF------KRLK------ISSFVQY------CK------SCSFK------LLA-WT------DESDC------ATRKALEHF--DNLNKLMLISL-RGGQKQ---EYDK------PITW----KLWIGNWI---VRMAILATFIRYNLFLYFD------ESVQLDLYLANPFPGSER-QN-NTFLLILGVITIVIFS--LLREYYH---YIERAGFLIT-F------RIFC------IIRNHG-IY--WKPLKFNVKSGQFF-----NKI-VH------LIMTQGARLMV------FIWLYSVAFFSLL----HL------NYSAA-YS------TGVHI-F----FILCVIPSE------IVTFALLINGLVSLGIYLWTFIALFNAKLEAI------RDDI-KI-CLRK-CS------LSPV------E-LSQ-----I-NEKVILFMNEIEETYRRLDYLHLYLVGLIAMQADFMLLLSLIFKLFPG------FINTL-ATMGGIAAHFFLVIGNYWASSY------HTKTLSMHGRY-TGLIFY-T------KA--NCSARFKALEVQDRINARQTGIAIGNLC-LITPSFSLLFILENINFIML---LTVNIRTLV------TuGR79/1-447 ------MT------SKFSS--NYSMKLLP-T------IENS------ERLK------ISNFVQY------CK------SYSYK------LLA-WT------GESDC------ETRKALERF--DNLNKLMLISL-RGGQKQ---EYDK------PITR----KLWLGNWI---VRIAILLSFTRLNLWLFFH------QSDQLDLYLANPFPGSER-QN-NTSALILAYVSVVNIS--SLREYYH---YIERAGYLIT-L------RIFF------NIRNHG-IY--WKPLKFNARSAQSF-----NKI-VH------LIMTQGSRLMV------FIWFYSAALLIRV----HL------NYPAA-YS------TGVHI-F----FILCFIPSE------VIALAVLVNGLASLGIYLWTFIALFNAKLEAI------RDDI-KN-CLRK-CS------LSPV------E-LSQ-----I-NEKVILFMNEIEETYRRLDYLHLFLMALIATQADIMLLLALIFKLFPD------FINSL-VTFGGMAIHFFLVIGCYWASSY------YTKTLSMHGQY-TGLILY-T------KA--NCSARFKALEVQDRINARQTGIAIGNLC-LITPSFSLLFILENINFIML---LAVNIRTLV------TuGR80/1-432 ------M------TGNF------ERLK------ILYFVQY------SK------SFFYK------FLA-WT------GESDS------ETRKSLAHF--DSLNKLTFISL-RGGQKQ---EYDK------PIAR----KVWIGNWI---VRIAILLTLIRINLFLYFD------ESGQMDLYLANPFPDSKR-QK-STFLLILGDVTVGIFF--FLREYCH---YIERSGYLIT-L------RIFF------NIRNHG-IY--WKPLKFNAKSAQSF-----NKI-VH------LIMTQGARLLI------TVWFYSIALIIVF----HT------NYPAA-YS------TGVHI-F----FILCIIPSE------IVTLASLINGLVSLGIYLWTFIALFNAQLEAI------RDEI-KT-CLRR-CS------LSPV------E-LRR-----I-NERVILFMNEIEQTYRRLDYLHLFLMALIATQADFMLLLSLIFKLFPD------SINSL-ITMGGITVHFFLVIGSYWASSY------CTKTLSMHGRY-TGLILN-T------KV--NCSARFKALEVQNRINARQTGIAIGNLC-LITPLFALLFILENINFIML---LAVNIRTLV------TuGR81/1-451 MESR------DSNLMLS------DRLHSNK------M------VRIV------GLLK------EPNYRHY------LK------SCFYK------LIG-WT------DGADI------ETRRALAHF--DYLNKLFLVSL-CGGQKQ---EYGK------PITR----KVWISNWI---IRIVILSTFIRTNLFLYFH------GCHQMDLYLANPLSNATR-SK-KIVFFIYFDVTLLILS--GLREYCH---YIERSSVLVP-F------RIFF------NIRKHG-VK--WKPLRLNMRHSKLF-----NKA-CY------FIITNGTRISV------FICFYSALLIFGI----RL------YFSN-YS------TLLHI-I----FILLFTAFE------ITMMVTCITLLVSLGVYLMALIAFFNAQADTI------IDEI-QD-SLRK-VP------LSPQ------E-LRQ-----V-NGKVIQFLNNIEKTYLRLNYLYLYLEVFIAFEVDLVLFLVLFTDSLLST-----SFIASI-FVVGSLLIHAFLVIGNYWASRY------HTKTLSIHGYY-TGLILN-T------KT--ICSAQFKALEVQDRINGNKTGIAIGDFC-LITPAFSLIFILENINFIML---LAVNVKTMI------TuGR82/1-433 ------M------IRII------EKRR------NPNYRDH------FK------SCLYK------LIG-WT------GESDV------ETRRALAHF--DYLNRVFLISL-CGGQKQ---EYDK------PITR----SVWISNWI---IRIAILSTFIRTNLFLYFH------GCHQMDLYLANPMPNAER-SK-KIVFFILMDVTIVIFS--LLREYCH---YIERSSVLVP-L------RIFF------NIRKHG-VE--WKPLRFNSRCSKIF-----NKA-CY------FIITNGTRLLV------FICFYSILLYIAF----RF------YFSN-YS------TVLHV-I----FILLFTAFD------VTVMLSFIVLLASLGIYLMALIAFYNAQADTI------RDEI-KH-YLRK-VA------LSSE------E-LRQ-----V-NGKVIQFMNDIEKTYLRLNYLHLYLEVVIAFEVDFVLFVVIFTDSLPTT-----FFVTFF-IFSVAFVVHAFLVIGNYWASRY------YTKTLSIHGYY-NGLILN-T------KT--ICSAQFKALEVQDRINGNKTGIAIGDFC-LITPAFSLIFILENINFIML---LAVNVRTMI------TuGR85/1-432 ------M------IEMI------EKLK------PSNFRRY------LK------PFLYK------LIG-WT------GESDT------ETRKALARF--DYLNQLFLVSL-CGGLKQ---EYDK------PITR----KVWIANWI---ARISVIYTVIRMSLFLYYP------GNDEIDLYLANLIPEDVQ-PM-KSAFLILTNIIFAILF--ALREYIH---YIERAGYLTA-F------RAFL------NIRIHG-VS--HAPFMLTKRCSQLF-----SKV-CH------LLMINAIRILI------FVCTYTLSYTLIL----RL------YFSAT-YS------TKLHV-F----FMILHIIIE------TVALLALFSALANIGTYCWTLALLITSGIDSV------IDQI-KY-CLNK-PP------LSQV------E-LKQ-----I-NERVILVFNYVDQLNRQINYLLLFLDGLIAVAGDLLLLFSLIFNLFPD------FISKI-ITFGGILIHFFLVIGNYWASRY------YVKVLSVHGYY-TKLVLN-T------QT--ICSARFKALEIQERINGNKTGIAIGDFG-LITPEFALIFILENINFIML---LTCNINSLL------TuGR83/1-432 ------M------IEMI------AKMK------PTDFRQN------WK------PFLYK------LIG-WT------GESDI------ETRKALARF--DYLNQLLLVSL-CGGQKQ---EYDK------PITR----KVWIANWI---VRISVIYTMIRASLFIYYQ------GNYKLDLYLANTIPEDVQ-PM-KTAFYVLFDIIFFILF--ALREYIH---YIERAGYLIF-L------RFFL------NIRIHG-VS--HAPFMMNKRCSQKL-----NKV-CH------LFMINGIRIMI------IMWTYLVSLTLTL----RL------YFPST-YA------TKLHI-F----FIILHVPIE------TVAIMTLFSALANIGIYCWTLAYLVSLGMESA------IDHI-KY-CLNK-PS------LSQV------E-LKQ-----I-NERVILVFNYVDQLNRQINYLLLFLFGLIAVASDLSLLFSLIFNLFPD------FISKM-CTIGAITIHFFLVIGNYWASRY------YVKVLSVHGYY-TKLILN-T------RT--ICSARFKALEIQERINWNKTGIAIGDFG-FIVPQFALIFILENINFIML---LTCNINSLV------TuGR84/1-432 ------M------TEMI------EKLK------PSNLRQY------LK------PFLYK------LIG-WT------GESDI------ETREALARF--DYLNQLLLVSL-CGGQKQ---EYDK------PITR----KVWIANWI---ARISSIYTVIRMSLFLYYQ------GNDSIDLYFANTIPEDVQ-PM-KTAFFTLAAIIFLILF--ALREYIH---YIERAGNLIS-L------RYLL------DIRIHG-VS--HAPFMLNKRCSQKL-----SKV-CH------LFIVNGMRILI------FMCIYTLSFTLVL----RL------HFPAT-YS------TKMHI-F----FIILHVPIE------TIALVTLFSGLINIGIYLWTLAYLATLGMESA------IDHI-KY-CLNK-PF------SSQV------E-LKQ-----I-NDRVIEVLNTMDQSNRQINYLLLFLDGLIAVAGDLLLLFSLIFNLFPD------FISKI-ITFGGILIHFFLVIGNYWASRY------YVKVLSVHGYY-TKLILN-T------RT--ICSARFKALEIQERINGNKTGIAIGDFG-FIVPQFALIFILENINFIML---LTCNINSLV------TuGR86/1-429 ------MI------EKLK------SLNFRRY------LK------PFLYK------LIG-WT------GKSDI------ETRRALASF--DYLNQLFLVSL-CGGQKQ---EYDE------PITR----KVWIANWI---ARISSIYTVIRISLFICYQ------GNDEIDLYLANLIPEDVQ-PM-KTSFLILTIIIFSILF--AVREYIH---YIERAGYLIS-F------RFFL------DIRIHG-VS--CERFNLNKRCSQLF-----NKI-CH------LFMVNGIRILI------FMCTYTLSFTLIL----RL------YFPST-YS------TKLHI-F----FMILHIIIE------TFALLALFSSSICIGIYCWTLAFLATSSMESA------IDHI-KY-CLNK-PF------LSQV------K-LKQ-----I-NGRVIKVLNAMDKSNRQINYLMLFLDGLIAVAGDLLLLFSLIFNLFPD------FISKI-ITIGGITIHFFLVIGNYWAARY------YVKVLSVHGHY-TKLVLN-T------RK--IGPARFKALEIQDRINGNKSGFAIGDFG-LITPLFALIFILENINFIML---LACNINSLV------TuGR90/1-432 ------MF------QKLK------SVNLRRN------LK------SFLCK------LIG-WT------GESDI------PTRRALARF--DYLNQLLLVSL-CGGQKQ---EYDK------PITR----RVWIANWI---VRISVIYTMIRLSLFMYYQ------GNDEIDLYLANFLPEDVQ-PM-KSAFLILTNVTFFTLF--LLREYIH---YIERAGYLIS-L------RYLL------DIRIHG-VF--YERFMLNKRCAQLF-----NKI-CH------LFMINGIRLSI------SACIAAFLITITF----RF------YFPGN-FT------TKMHV-F----YAILHIPIE------TVALMTLFTALINIGIYLWTFAALVTSRIDSI------IDQI-KY-CLNK-PY------LSEA------E-LRQ-----I-NHQVIHVFNNIDDSSRQLKYLLLYLDGLIAIEADIILLFALIYKLFPD------FVSKL-VSFGGFLIHFFLVIGTYWASSY------YIKVLSVHGYY-TKLIMN-T------GK--ICPARFKALEIQDRINGDKTGIAIGDFG-LITPQFALIFILENINFIML---LTCNINSLVEIS------TuGR87/1-435 ------M------IEMI------FKLK------PSNLPRY------LK------SFAYK------LIG-WT------GESDI------ETRIALARF--DYLNQLFLVSL-NGGQKQ---EYDK------PITR----RVWIANWI---ARISVIYTVIRMTIFIYYQ------GNDEIDLYLANLIPEDVQ-PM-KTSFLILTNITFSVLF--MLREYIH---YIERAGYLIS-F------RFFL------DFRIHG-VF--YERLNLTKRCSQLF-----NKI-CH------LFMINGMRLLI------GSCVGIFAIAIAF----RL------YFPRT-YA------TKLHV-L----FVILHIPIE------TIATMTLFSPLINIGVYLWTFAALTTARMDSI------IDRI-KY-CLDD-SN------LSLS------E-LRQ-----I-NLQVIQVFNYIDKSSSHLNYLLLFLDGLIAIEADIMLLFALIYKLFPD------VISKI-ISFGGITIHFFLVIGTYWASNY------YVKVLSVHGYY-TKLILN-T------QT--ICSPRLKALEIQDRITMNQTGIKIGDFG-LITPELALLFILENINFIML---LTCNINSLVETS------TuGR89/1-432 ------MI------EKLK------PTNFRQY------LK------PFLFK------LIG-WT------GESDI------ETRRALARF--DYLNQLFLVSL-CGGQKQ---EYDK------PITR----RVWIANWI---ARISVIYTVIRMSLFICYQ------DNDQIDLYLANFLPEDVQ-PM-KTAFLVIANIAFSILF--MLREYIH---YIERSGYLIS-F------RFFL------DIRIHG-VS--CGRFNLNNRCSQLF-----NKI-CH------LFMVNGIRIMI------FACIISFLITISL----RL------YFPGN-FA------TKMHV-F----YAILHIYIE------SVALITLTTALGSIGIYLWTIAALIMARIDSI------IDQI-KY-CLNK-PN------LREA------D-LIQ-----V-NFQVIQVFNHIDKSSRNLNYLLLYLDGLIAIEADIMLLFALIYKLFPD------LISKI-ISFGGIAIHIFLVIGTYWASSY------YVKVLSIHGYY-TKLILN-T------RT--LCAARFKALEIQDRITMNQTGILIGDFG-LITPEFALLFILENINFIML---LTCNINSFIEIS------TuGR88/1-432 ------MI------AKLK------SSNFRQH------LK------PFLYK------LIG-WT------GESDI------ETRKALARF--DYFNQLFLVSL-NGGLMQ---EYDR------PITR----RVWIANWI---ARISVIYTVIRMSLFICYQ------GNAKIDLYLANLIPEDVQ-PM-KTAFFILTNITFSVLF--LLREYIH---YIERAGYLIS-F------RFFL------DIRING-VS--CERTNLNKRCGQLF-----NKI-CH------LLMINGIRLLI------VVCVAAFLVIISL----RL------YFPGN-FA------TKMHV-L----FVILHITIE------TVALITIFSPLINIGVYLWTIAALTTARMDSI------IDQI-KY-CLDG-SN------LSQA------E-LRR-----I-NYQVIYVLNDIDKSCRNMNYLLLYLDGLIAIEADIMLLFALIYKLFPN------VISKL-ISFGGITIHFFLVIGAYWASSY------YVKVISVHGYY-TKLILN-T------RT--ICPARFKALEIQDRINGNQTGILIGDFG-LITPEFALIFILENINFIML---LTCNINSLVEIS------TuGR91/1-433 ------M------IEMI------RKLK------LSNLRRY------LK------RFFYK------LIG-RT------GESDI------ETRQALARF--DYLNQLFLVSL-CGGQKQ---EYDK------PIPR----KVWIANWI---ARISVIYTFTRVSLFMCYQ------GNDKIDLYLANLISEDVT-PS-KTSMLALTNITIFILF--ALREYIH---YIERSGYLTS-L------RSFV------DIRIHG-VT--YEPLKLNERCSRIF-----SKI-CH------ILMINGIRSLI------LLCVWATSLTIML----RL------YFSAT-YA------TKERI-F----FMIFHIPIA------IVALITVCSSLLSIGFNLWALLAFQIAHIDSI------IDQI-KY-LFSK-LP------LSQP------E-LRH-----V-NEQMISVLNDNDQTNRQINYLLLYLDGLIAIEADIMLLFTLVYKLFSD------FISKL-VSFSGILTHFFLVSGTYWASRY------H--VLSIHGYY-TKLVLN-L------KA--TCPAKFKALEVQDRIKRNETGISIGDFA-TFTARFSLIFILENINFIML---LACNINSLLYPS------TuGR92/1-435 ------M------LERI------FKLK------PSNLPRY------LK------SFLYK------LIG-WT------GESDI------ETRKVLARF--DYLNQLFLVSL-CGGQKQ---EYDK------PITR----RVWIANWI---ARISVIYTFTRVNLFMYFQ------DDQKIDLYLANLISEDEM-PS-KTSMLVLTNITIFNLF--VLREYIH---YIERCGHLTS-L------RYFH------DVRIHG-VT--YEPLMFNKRCSQIF-----SKT-CH------LFILNGIRLFF------LICTYALSLTIML----RL------YFPAT-YS------TKMHI-F----FMILHIPIE------TVAFITLFSALASIGVYLWTLGAFHIARVDSI------VDQI-KY-CLNK-PP------LSQA------N-LRQ-----I-NERVILVSNYIDKSNGQINYLLLYLDGLIAIEADIMLLFALIYKLFPD------FISKL-VSFGGITTHFFLVIGTYWASRY------HVKVMRIHGYY-TKLVLN-A------RA--NCLAKFKGLEIQDRITENKTGIAIGDFG-MITPRFALIFILENINVIML---LTVNINSLVYSS------TuGR93/1-432 ------M------TTQNSFE------IKWK------LV------K----SKIAF------TFG-L------SSS-ERSVG------KISALIGKI--HSLTLLTL-VL-RKGYHQ---DGKPWNE----KEAS----NFKKRNDF---LRLCLLIMILRFIFFIFTE------EPSNITMILGNAFYSSTK-SR---TLNLLELIYISMLV--IAREYIL---YCESKGRLSF-L------LDMR------TLNTS-LN--SYALKMSPVQFDLF-----VRR-VQ------FTLFNWSNLFY------PFSFILVLGLAIV----RL------MNVQV-YF------NLIYL-V----SSAIWFIPE------TATVVCLVWGLAAIGTYSFILSYFYLAWLQSQ------LDRL-RI-LRRS-TQ------SAEM------NYL-LKS-----V-NFDLQKVFLHFDRMANDLNYLIGYAVFGISFMMVIAISFSNFLKLHSP------LLANV-ILIATFLGVVCMTAILHSSTQI------YTKYNQICGYY-SSFMARQY------GL--QIHNGLKILHILEKCS--YNGIRIGDLT-LLTSTFLCYFILENISAIML---ITVNIRSFES------TuGR94/1-432 ------M------TAQTSFE------IKWK------LI------K----SQIAF------TFG-L------SKS-EHSVE------KISNLIGKI--HSLTLLTL-IL-RKGYHQ---NEKPWNE----KETF----NFKKRNNL---FRLCILIMTLRFIILINTE------EPSNISIILGNAFYSSTK-SR---ILNALECTYISMLA--LVREYIL---YLESKGGFSL-L------SDMK------ILHNS-LN--CYALEMSPAQFDIF-----ISH-VQ------LNLFNWSNLFY------PFSCFLVFGIAVV----RL------FNVQL-YS------NYVYA-I----ASAAWFVPE------MATALMLSWGCGAIATYSFTYSYIYLARLQSQ------LDRL-YI-SYRT-TQ------STEM------NYI-LKS-----V-NFDLQKVFLHFDRMANDLNYLIGYAVLAISFLMVTAVVFSNFLKLHSP------LLANL-ILIVTFLGVISITVILHSSAQI------YTKFNRICGYY-SSFMARHS------GV--RVHNGLKVLHILEKCS--YNGVKIGDLT-LLTSTFLCYFILENISAIML---LIVNVRSLEY------TuGR95/1-425 ------M------SICNQI------CS------IK------TCLRC------YFG-T------KDDSK------LVGKVIDKF--NSILLETC-VL-KKGYHQ---DREN------SYSGLP--NFGSWLFT---LRLLSSVVILRFLIMISMN------ETSYIHVILGNQFYLAST-SY---IFHAILLAFCMLGL--ISREYCL---IMEARGDLHF-L------SQIL------IIKDHG-FD--ESRLNLSSYQAYIF-----KKR-TQ------FCLLFWLYFIY------PLCYFFVPMIIFV----HL------SNPNI-WS------NPVYL-V----SSTMWCATE------IFTVIHLNTSLSAVVCTILILIWLCVGRMKTV------MERL-TL-M-TC-DQ------VDQI------GMQ-LAQ-----T-NCFFIHFLNDFRSLVFNVKYYVLYNFLIIAAASDFAIFFGFIIKIHSP------LTSNL-LAFTGFLAIAVGSLIIYACSAF------WCQFNLFCGIY-SAFLAR-S----KAKL--NTNQGLKILHILEMCS--YNGIKMGDLC-IMQSTLLVYFLLENAAAIML---LVVNLRSLDA------TuGR96/1-428 ------M------FN------VSICNQF------CS------IK------TCLRC------YFG-T------KDDSK------LVEKVIDKF--NSILLETC-VL-KKGYHQ---NREN------SYSGLP--NFGSWLFT---LRLLSSVVILRFLIMISMN------ETSYIHVILGNQFYLASA-SY---IFHAILLAFCMLGL--ISREYCL---IMEARGNLQF-L------SQIF------IIKDHG-FD--ESRLNLSSYQAYIF-----KKR-TQ------FCLLFWLYFIY------PLCYFFVPMIIFV----HL------SNPNI-WS------DPVYL-V----SSAIWCTTE------IFTVIHLNTSLSAVVCTILILIWLCVGRMKTV------MERL-TL-M-TC-DQ------VDQI------GMQ-LAQ-----T-NCFFIHFLNDFRSLVFNVKYYVLYNFLIIAAASDFAIFFGFIIKIHSP------LTSNL-LAFTGFLAIAVGSLIIYACSAF------WCQFNLFCGIY-SAFLAR-S----KAKL--NTNQGLKILHILEMCS--YNGIKMGDLC-TMRSTLLVYFLLENAAAIML---LVVNLRSLDA------TuGR97/1-426 ------M------SICNQF------CS------IK------TCLRC------YFG-I------KDDSK------LVGKVIDKF--NSILLETC-VL-KKGYHQ---DREN------SYSGLP--NFGSSLFS---LRLLSSIAILRFIIIISTN------ETSYIHVILGNEFYSASV-SY---IFHAILLAFYMLGL--ICREYCL---IMEARGDLSF-L------SQIL------IIKDHG-FD--ESMLNLSSYQAYIF-----KKR-TQ------FCLLFWLYFIY------PICHSFVPMLIAV----HL------FNPSF-WS------NPVYL-V----SSTIWCTIE------VITFIHLNKSISAVVCTILIFIWLCVGRMKTI------IERL-IL-ISTC-DQ------VDQS------GIL-VAS-----T-NRFFIQFLNDFRSLVFSVKYYCFYNFIIIAAASDFAIFFGYIIKIHSP------LTSNL-LGYSGFLAIAVGSLIIYACSAF------WFQFNLFCGIY-SALLAR-S----KIKL--DTIQRLKILHILEMCS--YNGIKIGDFC-IIKRTLLVYFLLENAAAIML---LVVNLRSLDA------TuGR98/1-431 ------M------VNQQM------LSFN------LT------RHFHS------LLG-F------NSDHK------IIRKAITRF--NSVSLYTF-ML-KNGCRQ---HQSS------SSLP----NFTLKLLT---IRLLVLIMAIRYTILTFSN------HTSSVHTFLGNPFYLFSS-SP---IFNGLMLAYLVFLN--FCREYWL---YLESKGCLEF-L------TQLF------VIHDHG-FS--RHLLALSLLQSNRF-----KRL-AS------FCLIYWFKNIH------PFYYSLIPLFMAL----HA------ANPFM-WS------NSIYF-V----ASSIWCLIE------ISIFLISVNSLVISYCIAFIFTSLYVSRLTTL------TEQL-ST-LAIH-QQ------SSDC------RRE-VES-----I-NRLFISFSNDFDEKTRIFRYFSFLFFMGMSITMDVSIFLGLIIKIHSP------LVTYL-LSFSGLASLVASTAIIFLLSKF------WNQFNRFCGCY-SALMAQ-AG---DFTL--NIQQKLKILYILERCS--YNGVRIGDLC-FIQKSLIIHFFLENASTILL---LVVNLRSLQDGSYKG------TuGR99/1-428 ------M------EEA------IEAQ------PTQRD------LV------KRFKY------LIG-L------PDE-IDADE------YAGKAITIM--EKCARSLL-IT-RRGYHQ---SRRD------YQFE----DYTWKNSL---GRAILIFVGLRITIIAIVP-----ADNQLVTVFLGNPFHGKSY-SQ---EVALLTLLLLTVLS--ILREVAI---YIEDAGYIMD-L------QFLR------IIQIYG-FD--HKLLFLTPKQCKAM-----KPV-LI------FHVVNWTRMLR------FNKFANGVIMLSF----RL------FDPLF-YS------NPVYF-I----TSVFWIVME------TFAARMSFTALLNVGGHTIVMVPWYIFRLRSV------HEMV-VK-VNSM-DR------ISES------R-LKH-----L-TRSLLFYLNCYDKIMKDCRYLFFYCIFFVSFLADTVIFMAIVSSYPSH------IIGT--FYFAGFFCITAIGSVIYFAGEF------VDRPNIIHGLL-TKIIHK-C------QA--GYEEKLNMHKVLDRIAIYGTGIRIGDVINKIERDLFVFYILENASTVML---LICNIRTA------TuGR100/1-428 ------M------EEA------IEAQ------PTQRD------LV------KRFKY------LIG-L------PDE-VDADE------YAGKAITIM--EKCARSLL-IT-RRGYHQ---SRRD------YQFE----DYTWKNSL---GRAILIFVGLRITIIAIVP-----ADNQLVTVFLGNPFHGKSY-SQ---EVALLTLLLLTVLS--ILREVAI---YIEDAGYIMD-L------QFLR------IIQIYG-FD--HKLLFLTPKQCKAM-----KPV-LI------FHVVNWTRMLR------FNKFANGVIMLSF----RL------VDPLF-YS------NPVYF-I----TSVFWIIME------TIAARMSFTALLNVGGHTIVMVPWYIFRLRSV------HEMV-VK-VNSM-DR------ISES------R-LKH-----L-TRSLLFYLNCYDKIMKDCRYLFFYCIFFVSFLADTVIFMAIVSSYPSH------IIGT--FYFAGFFCITAIGSVIYFAGEF------VDRPNIIHGLL-TKIIHK-C------QD--GYEEKLNMHKVLDRIAIYGTGARIGDVINKIERDLFVFYILENASTVML---LICNIRTA------TuGR101/1-421 ------M------H------RLSSK------LT------IKRLKS------VVG-L------PDD-ADAAQ------HVNQLIDTM--ETTARGLL-VT-KRGYEQ---YMRD------FCYE----GYAWKNNL---VRCVIVVTIIRLAVLLVYY------DNELVSLVLADPIGEKSV-GF---ILIAFAELILCTLS--LLREYAL---YLEESGAIMQ-L------QILK------TIQRNG-FN--PNLLYLSPTENLKF-----QRI-FI------FIATNWTNFIR------LSKLIAPIVLITL----KM------QHPKV-FQ------DKLFA-Q----MTILWTVSE------IIVARFVVTGLLNTGGHLIILFPWYVGRISTL------IGMC-KD-LLQS-PR------IRTK------E-LIE-----F-NRMAIHFLNDFTTNVTSLKLIFFYLFVIISFCADSIIFLAIAAPLPDE------MKYL-LMSIGLIGLTIIGIVSYSAGGI------VDMFNQIHGLL-IQIMPR-S------NS--RLESKLKVDEIICRLQWPDTAPKIGDFC-IVVRELFVYYILENASTIML---LKCNVRTQ------TuGR102/1-445 ------M------LAFVNRRFIFFI--RTILESI------SRCIPFQ------IK------ALIKR------SFG-F------LSD-NDSDE------EIIKSLQVL--ENIGLGLI-IS-RRGYSQ---DETS------YVQP----HFHFNNNL---IRFVSILNFIRFYLILIYK------QNDNLSILLGNPFFHENS-SD---MMIYYVIGGGITLF--ILREYVL---YLEEHGAYTI-L------CPFR------DIKVSG-FD--KNMLKLTTKQCKSF-----HST-FH------ILITIWIRWIY------CTFICIPFVLISL----RL------QNQAIVNS------GPAMY-I----SSFCWIILE------SCAFVFIFGGLLTIGAHMCVSVPLYLFRLKSL------IELL-KR-VKSK-QF------IDDS------Y-IKG-----M-NTDVISYMNEFDEIIAKNRYIYFFLFIIISFGADTAIFLGLFTKRHSN------WVSNM-LVIWGLIILFITGSVVYAGGAF------LDQLYVIDGLY-VSIIAK-A------QQ--KLDQKLKTLEILDRILSPYSGAKIGDAF-RGEKLLAVYYVLENASTIML---LICNLQLISSQ------TuGR103/1-445 ------M------LTFINSRFIFFI--CTILESI------TRCIPFQ------VK------ALMRK------PFG-L------LGD-DETDE------KTVKLIKVL--ENIALGLI-IS-RRGYAQ---DETS------YVQP----NFHFKNNL---IRFVSILNFIRFYLILIYK------QNDNLSILLGNPFFHENS-ND---IMMYYVIGGGITLF--ILREYNL---YLEETEAYAL-L------CPLR------DIKISG-FD--SNMLRLTTKHCKLF-----RST-LH------PLITIWIRWIY------CVFICTPFVLISL----RL------QNQAIVDS------GPAMY-I----SSFCWIILE------SCTFITIFGGLMVLGAHISVSVPLSLLRLKSL------IELL-QR-VKSK-QF------IDGS------F-IKA-----M-NSDLISYMNEFDEIIAKNRYLFFFNFLIISFGADTAIFLGLHTKRHSK------WISNS-LVIWGLIILFITGSVVYAGGAF------LDQLYVIDGLY-VSIIAK-A------QQ--KLDQKLKTLEILDRILSPYCGAKIGDAF-RGEKLLAVYYVLENASTIML---LICNLQFISSQ------TuGR104/1-450 ------M------LSFANGRFIVFV--YAILESI------SRLIPYP------VK------NLIKK------SFG-L------LSD-NESDE------EIIKSLQVL--ENIELGLI-IA-RRGYGQ---DETS------YVQP----NFHFKNNL---IRFVSILNFIRFCLILIYK------QNNSLSILLANPFFHENS-SD---IMIYYIIGGGITLF--ILREYVL---YLEEHGAYTI-L------CPFR------DIKVSG-FD--KNMLQLTTKQCKSF-----RST-FH------ILITVWIRWIY------CTFICMPFVLISL----RL------QNQAIVNS------GPAMY-I----SSFCWIILE------SCAFIFIFGGLLTLGAHITIFVPLCLCQLKSL------IELL-QR-VKSK-QF------IDDS------Y-IKG-----M-NTDVIRYLNYFDCFIAKLRYIYFFLFIIISFGADTAIFLGLFTKRHSN------WVSNM-LVIWGLIILFITGSVVYVGGALWI-RYGMNLLYLIHGLY-VSTIAK-V------EV--KLYQKLKILEILDRILGPYCGAKIGDAF-TAEKLLAVYYVLENASTIML---LICNLQFISSQ------TuGR105/1-445 ------M------LAFVNSRFIFFI--RTILEAI------SRCIPFQ------IK------ALIRK------YFG-L------LSD-DDSDK------ETIESIQVL--ENIGLGLI-MT-RRGHRQ---DETS------YVQP----HFHFKNNL---IRFVSILNFIRFGLILIYK------QNDDLNILLANPFFHENN-SN---IMIYYAIGGGITLF--ILREYSL---YLEETEAYAL-L------CHLR------DIKVSG-FD--KNMLRLTTKQCKSF-----RFT-LH------LLITIWIRYIY------CVFICTPFGLIIL----RL------QNQAIVNS------GPAMY-I----SSFCWILLE------SCTFVFIFGGLMDLGAHITVSVPLSLFRLKSL------IELL-QR-VKSK-QF------IDDS------F-IKG-----M-NSDVISYMNEFDEIIAKNRYLFFFIFVLVSFGADNAIFLGLFTKTHSK------WISNT-LVIWGLITLFITGSVVYAGGAF------LDQLYVVHGLY-VSIIVK-A------GV--KQDQKLKALEILDRILSPYCGAKIGDAF-RGEKLLAVYYVLENASTIML---LICNLQFISSQ------TuGR655/1-445 ------M------FAFFNCRFIFFI--CTILESI------SRCIAFQ------IK------ALIKK------SFG-L------LSD-DDSDE------ETVKSIQAL--ENIALGLI-MT-RRGYGQ---DETS------YFQP----NFHFKNNL---IRFVSILNFIRFYLILIYK------QNDSLNILLGNPFFHENS-SD---IMICYVIGGGVTLF--ILREYVL---YLEETGAYAL-L------CPLR------DIKCSG-FE--TNMLRLTIKQCKSF-----RCT-LR------LLIKIWIRWIH------CAFIFITFLLIIL----RI------QNQAIVNS------GPAMY-I----SSFCWIILE------FCAFIFIFVGLMYIGAHISVSVPLVLFRFKSL------IELL-QR-VKSK-QF------IDDS------I-IKG-----M-NSDVISYMNEFDVIIAKNRYLFFFLVVLVSFGADTAIFLGLFTKSHSK------WISNS-LVIWGLIVLFITGSVVYAGGAF------LDQLYVIHGLY-VSIIAK-A------EV--KLDQKLKTLEILDRILSPYSGAKVGDAF-RGEKLLAVYYVLENASTIML---LICNLQFISSQ------TuGR107/1-446 ------M------LPFANCRFIFFICRVNILESI------SRRIPFQ------VK------VLIKK------FFG-L------LSD-DDSDE------ETVKSIQVL--ENIALGLM-MT-RRGHRQ---DETS------YVQP----HFHFKNNL---IRFVSILNFIRFYLILIYN------QNDNLSILLGNPFFHENS-SD---IMICYVIGGGITLF--VFREYVL---YVEDTRAYPV-L------CTLR------DIKVSG-FD--SNMLKLTTKQCKWF-----RST-FH------LLITIWIRWIY------CVFICTPFALIIL----RI------QNQAIVNS------GPAMY-I----SHFCWIVLE------SCTFIFIFGSFLNLAAHVTVSIPLYLCRLKSL------IELL-KR-VRSK-QF------IDDS------I-IKG-----M-NTDVISYMNEFDKNIVTIRYLFFFVFILVSFGADTAIFLGLSTKGHSK------WVSNM-LVIRGLLVLFIVGSIVYVGSAT------LDQLYVIHGLY-VSIIAK-A------SV--KLEQKLKTLEILDRILSPYCGAKVGDAF-RGEKLLAVYYVLENASTIML---LICNLQFISS------TuGR106/1-445 ------M------LPFANCRFIIFI--CAILESI------SRFIPFQ------NI------AFSKK------SFG-L------LSD-DDSDE------ETVKSIQVL--ENIALGLI-MS-HRGHRQ---DETS------YVQP----HYHFNNNL---IRFVSILNFLRFYLILIYK------QNDNLNILLGNPFFHENI-SD---IMVYFVIGIGITLC--ILREYVL---YLEETGAQAL-L------CNLR------DIKVSG-FD--KNMLKLTTKQCKLF-----RST-FH------LLITIWIRWIY------GVCICTPIVLLNF----RI------QNQEIVNG------GPAMY-I----SHFCWIVLE------SCTFIFIFVGLMDLGAHITVSVPLYLFRLKSL------IEML-KR-VKSK-QF------IDSS------F-IKG-----M-NTDVISYMNEFDEIIAKNRYLFFFIFVIISFGADTAIFLGLFSKGHSK------WISNS-LVICGLLELFICGSVVYVGGAF------LDHLYVIHGLY-VSIIAK-A------EV--KLDQKLKTLEILDRILSPYSGAKVGDAF-RGEKLLAVYYVLENASTIML---LICNLQFISSQ------TuGR108/1-425 ------M------SRFIPFQ------IE------ALIKK------SLA-L------LSD-DDGDE------ETLKSIQVL--ENIALRLI-IT-RRGHRQ---DETS------YVQP----YYHFNNNL---IRFISILNFVRFYLIMIYK------DDHLHVLLAHPFLNKSS-AD---MMLRFVIGAGITLF--VLREYVL---YLEETGAYEL-L------STLR------DIKVSG-FD--KNMLRLTTKQCKLF-----RST-FH------HLITMWIRLIY------GVVILTPFLLIGL----RI------QNEAIVNS------GPAMY-I----SSVCWMFLE------GYCFIFIFGGLLDLGAHIIILVPLYLCQLKSL------IELL-KR-FKIK-QF------IDDS------I-IKG-----M-NTNVIRYMNYFDDLSVKIRYLFFFLFVLVSFGADTAIFLGMSIKSDST------FISNL-FGLCGLITLFIVGSVAYAAGAY------LDQLYVIHGLY-VSIMAK-A------KV--KLDQKLKTLEILDRILGPYCGAKIGDAF-TAERLLAVYYVLENASTILL---LICNLQRASSQ------TuGR109/1-454 ML------KKLAKEKSIKTELN--M------DRIKNF------ISLI------ADRFPSQ------VK------SLINK------IFG-L------LDD-ENVDDY------TETANRLQDL--ENIALWLY-IT-RRGHDQ---DKPE------IVQS----GYHLMNNL---IRLSEIIACTRLFTLCW-E------TSDEIQIYLANPFYKVQG-GQ---AMTFIISFLLFILS--LLREYIL---HLEDIGSSIL-L------TYLR------EIRQYG-FD--CKRLGLTEKQRKKF-----RVA-FH------IILVNWYRLIQ------FNIYIVPAFIAAV----HL------VNPALSLD------NPTFV-F----ASFFWFLSE------SFCFIYVACGTFDIGAHIAVLVPLFIFKIESI------IELL-ER-YLYNPKA------IEPY------L-IRQ-----L-NIETIRLLNVLDVMSRDLRYLFAFLIVGISFLADTFIFLGPILHIGSA------LHQSF-FSFLGFFTLSAIGLITYAGGNI------HGRLIIVHKIY-TRLLTK-E------KV--DFGTHSKAMEILDRIMGPFTGAKIGDFC-TIDRYLFVFYIMENASMVML---LVCNAQSYINY------TuGR110/1-438 ------M------DRIKNF------FSLI------ADRFPSQ------FK------SLINK------IFG-L------LDD-ENVDDY------TETANRLQDL--ENIALWLY-IT-RRGHDQ---DKRE------IVQS----GYHLMNNL---IRISAIILCTRLFILCY-E------TSDEMQIYLANPFYKLQG-AQ---AIAFMISSLVFTLS--LLREYIM---YLEDIGSSIL-L------TYLR------DIRQYG-FD--CKRLGLTEKQRKKF-----RVA-FH------LILVNWYRIIQ------FNIYIIPAFIAIV----HL------VNPAFGLD------NPTLI-I----TSFFWFLSE------SFCFIYVACGTFDIGAHITVLVPLFIFKIESI------IELN-ER-YLFSPKS------IEPH------L-LRQ-----L-NIDTIRLLNLLDVMSRDLRYLFVFVIVGISFLADTFIFLGPILHIGST------ILQNF-FSTLGFFILFAIGLISYAAGNL------HGRLIIIHKRY-TSLLAK-E------KV--DFGTHSKAMEVLDRIMGPFTGVKIGDFC-TIDRYLFVVYIMENASMIML---LVCNAQSYINY------TuGR113/1-437 ------M------FSWSD------IKMHKQIF------GFQS------LN------ASR----SSAFNDG------V------NDG-NVLGS------KAIEHVNTL--EYFLNHLY-VI-RSGYKQ---SKDERS-----TFMS----QFELHHRL---VQLSESLSLVRSIALFI-F------NDDTISILLGDPLFKFPG-RK---VCYILVIILSLAMG--LFREYAL---HLESRGNLTF-L------SKFE------QMKKPN-FD--KRSLKMTRIQFNKF-----RLV-FL------MIGSFFSLFMK------ISLPFIIAFSVGV----RL------NNESY-WS------TPSII-L----TSMFWIGFE------VHAFYFAACGVIVVAVHIIMVFPIYYYQMLSL------VELL-QK-FTVK-EES------VTHE------V-LRG-----L-SLNTIRFMNEFDHLNNQLKHLTAYVFVIFSFMGDYIIFSATVLSESST------ILSTL-MLFFGFSDLMVIGLTTFVLGGF------ITKLEVVYTLY-LRLMIK-S------KT--KLTQRFKPFEILSRIKGPYNGFQIGDLL-TADKAIFVYYLLENMSIVML---LLVNIGPLE------TuGR114/1-432 ------M------QSQI------SCQR------LQ------NGK----KCSKSDV-----EICA------SCR-NVMEN------KAIEHVETL--EYFLNHLF-IV-RSSYKQ---SQHERS-----TLMN----YFELNHRL---IQLSVSLNLVRFAALLI-F------NIDTISILLGDPFFKFPG-RK---VVYILVIILALTMG--LFREYVL---HLESKGCLQF-L------STFA------LIKKIG-FD--KRSLKMTDIQLQKF-----RHV-FY------TVGRYFSISMK------MCLPLIVALMIGL----RL------NNEIY-ST------NLSIW-L----TSIFWILTE------VHALYFAICGVVVIACHIIMVFPIYYYQMMSL------VELL-EQ-FSLK-EDL------VTAE------V-VRG-----L-SANTIRFMNEFDQLNDQLKHLISYVFVVFSFTADYFIFSATIMQRNSA------LLSTV-FFAFGAGVLSIIGFETFILGGF------ITKLNVIHALF-LRLMRK-S------KI--MFTKKSKPFEVLSRITGPYNGFKIGDMI-TVNKTIFVYYLVENASIIML---LSVNIRPFLE------TuGR111/1-430 ------M------K------LTW----KFDFK----SFIFN------DLLA-L------PV--SNQDN------ETIKSLVEL--EKLSYLCL-IT-QYGQTQ---QIDK------PVSI----KLKFAHFM---VRVLNLTFILRLICFLT-M------TDKTMQTIVADPVINTPN-RE---ILIVLQLFIVIVML--VVREYIL---YLENNRKFLI-L------RKLY------HIRKNG-FS--SDYLNLTERQFMFF-----KRN-LH------FILINSLRFSK------LTIVLLPFFGTGV----RL------NNPDS-LA------TNSLI-I----SACFWSITE------GLTFIFLYSGGILTVTYIFILMLLYFCQLRSL------VEST-QN-KIKC------LTDQNNQLGVAIT-LKS-----L-NYQSTSFLNQFDQLNSDFKYLWLNNVIVFSFLADSFIFFGAIVHINSD------YLSDV-LTYVGFFVLFMCAVGGYAGGVF------HQKLMYLHIHY-VRLLTF-S------SA--HIQDSFKALEIVDRIMHPDTGASVGDFT-VLKREFIVYYILENASTIML---LSCDVRSAISI------TuGR124/1-403 ------M------HFLSLF--ERLLVNFA-CL-RKGYQQ---SSEITK-----PLNP----HFDLINWT---IRLTTIVNLYRFVHLII-S------TDSRVNIYLGDPLYQSQD-RG---LLYSTMIFAMVVMF--IAREMFL---FLEANGYLTI-L------KVLN------TLKSSN-NQ--HFDHQMTPLKMSTF-----LRV-LN------FECLTICASMF------LSIPFILILLNCP----LI------VNLLS-FS------IPSLL-I----YALLWSISL------CFSSIFLLNAIFAQGACIIICGTYYFFKLKSL------CETI-DS-IITH-HYQQVKP------RIDQL------Q-VKS-----F-LVDVTLYLNEIDLHIKTLRYVILYFFLLITLNNNFYIFVGLIAKTKNE------IVNNL-ISAYGVLVVLLISLLCYIASDF------VEMINYVACKLNHVIVNF-N------GL--SIATKLKTIEFLDRSKSSYIGIKAGDFL-ILNKINFILFLLENASTLLL---LTVNLRPILD------TuGR123/1-449 ------M------KLGASF------RF------IT------K----TVYHA------FLG-I------PQL-NEHHD------STIYALDRF--ERYTIFFC-TL-RNGFRQ---YEVQPRQ---VSQSTFLRRFFGARNWS---IRLASALNFFRFLSLIF-I------EEESTRIYLGDNVFRSKD-RN---SICVLILSSIVVSI--FSREWFL---HIEAGHKCTV-L------NNYD------WIRNKGLFD--NVYLKMTVNQAKQF-----RIT-VH------FLLNLYNRIIV------VLVPFITILYNLP----FL------TNPYT-YR------IPLLA-F----YGSLWSLTL------TWSVVFLANEIFTISGYLFFICAVHYHRIESI------IEQC-NS-KPNS-IYSTRREY------SSIYLDKS------IIS--WASLCTSTWTDRINQFEFDFDRLRYLVLYYFTVVAFLGDLFIFLGLVVGAHSK------LVANM-IAMLGGLILVLCVIACYFTGGF------VTKLQLCHRKF-HSICCS-T------KL--PILNSLKILEIMDRSLGPRVGIKVGDLT-TITQMFFISFILEVGSTLML---FVCNVRGLFASN------TuGR133/1-440 ------M------NSI------SSSSAFSP-----SANSRIKL------LI------KVLAY------FIG-Y------PTK-DEPIS------STIKHLEYF--ERLTIFFR-VL-RFGFRQ---TKPVETLNFPIKTSS----TLDYNNIL---MRICYSLNLVRLFIITY-T------NNETLQIHLGDIVYRSKD-RF---QLNILLTSSMLILA--VAREWAL---ALESKGKMSS-L------NYYD------YIRING-FK--ADYLNMTQHQTNAF-----RTT-VH------ITAIFFSRVVV------STGPFVCIAYYSV----CF------TNPYY-YK------YYYLT-I----TCSIWSVII------CYSFITLLAQIFGFAGYLFIMTMIYLHQLESL------IEVS-QF-VRYS------GQDQ------H-IQQ-----F-IRKTIICLNNSETNSNKMKYFIFYAFTVCAFFGDLFTFYGLIINFYSE------MLATL-YATMGTLIFMLLGMVCFVANGF------INKIEKVYANC-HGICKS-N------KL--SIATYLKIFEFMDRSVVPINGVKIGDVT-VIQKTFFVKFIMEIASSLML---ITINLRQYFE------TuGR135/1-447 M------FQSFLVLTVQ------LSFDLFNKLK------M------KLF------SQWRSFS------MS------SPR---IKLNNL------LFG-L------PNQ-NLTSE------ETIEQLVKF--ERFLIFFR-AS--LGFIQ---NVSHRST------KTDYYGLI---IRAICRIYLIRLICLAV-I------DDEDYQLYLGDIAYKTKY-RS---MINVLFVIGFLIGV--GIKEWFV---LYDKSGKNSV-L------TIYS------DIINHG-FE--PVHLKMTSNQAIKF-----HRT-IH------ILVTQLNRNFT------FSCLFLAAVYYSV----LL------FNPHF-YQ------TKEFI-F----YSLVWSLVA------IITIFSVDATYFAIFGYLILIQVYYLFRLESV------VELA-DS-YRQL-K------CTDE------L-AST-----F-IKYTCKHLNQWEKCAKLTGVLVFCVFTAIAFICDLFIFYGFIMNFHSP------LFANS-FGSIGCIFCLVIACLSLIGREF------IIKIERLYSRL-HVIWRY-N------VF--NVYNRFKILQLMERLNGPYNGIQLGSIT-TIGKDFSVRFMLEIGSSLML---LTCNFKRYF------TuGR134/1-427 ------M------KLS------GQWRNYS------LS------SLK---TESTNL------FLG-L------PNH-GLTCE------ETIKQLVKF--EKFLIFFR-AS-RFGFNQ---NVSHQSV------KTDYVSLI---MRAIGQINLLRFICLTV-I------DNEDYQMYLGDTGYKTKH-RI---MLNVFFMIGFLVGF--VVNEWVV---LFDKSGKNSV-L------TIYS------SIIGHG-FD--PVYLQMTPNQAVKF-----HRT-IH------ILITQLNRNFL------FCCLFLAICYYFM----LL------SNPHF-YQ------VKEFV-F----YSLIWSLVA------MITTFTVLGKYIAIFGYLILMQLYHLFRLQSV------VELA-DS-YRRL-K------YNDE------D-ASN-----F-TKSTFECLNQSEKCAKLTGTLVLCVFTAIAFICDLFVFYGFIMRFHSP------VFANS-LGSIGCIVLLVIGYISLIGRKF------IIEIERLHTHV-HIIYRY-N------VS--TVCNQFKILQLMERLSEPNIDIQLGSIA-TIGKDFFIRFMLEIGSSLML---FTLNFKRYF------TuGR144/1-422 ------MYSIHELK------M------KLF------GQWRNYS------LS------SLK---TESTNL------VLG-L------PNH-GLTSE------ETIKQLVKF--EKFLIFFR-AS-RFGFNQ---NVSHPPT------KTDYLSLI---MRAIGQINLIRLICLTI-I------DNEDYQMYLGDTAYKTKH-RI---TINVFFIICFLIGV--VVHEWVA---LYDKSGKNSV-L------TIYS------DIINNG-FD--PVTLQMTPNQAVKF-----HRT-IH------TLITQLNRNFL------FCCLFLAICYYFM----LL------SNPHF-YQ------VKEFV-F----YSLIWSLVA------MITTFTLSGKYISIFGHLILMQVYHLFRLQSV------VELA-DS-YRRL-K------YNDE------D-ASN-----F-INSTFECLNQSEKCAKLTGTLVLCVFTAIAFICDLFIFYGFIMRFHSP------VFANS-LGSIAALFSSLL------IERLYTHI-HKIYRN-N------VL--TVCNQFKLLQLMERLSDPNIGIQLGLIT-TIGKYFFIKFMMEIGSSLML---FTLNFKRYF------TuGR140/1-447 ------MLNFDFLTFG------GFFHFYDKLK------M------KLS------GQWRNYS------LS------SLK---TDSTNL------VLG-L------PNQ-GLTSE------ETIKQLVKF--EKFLMLLL-AS-RFGFNR---KVLHQSA------KTDYFSLI---IRVMGQINLIRLICLTV-I------KNEDYQLYLGDTGYKTKH-RI---MINILYAICFLFGV--ATNEWLI---FYDKNGKNSV-L------TIYS------GIIKHG-FD--PVHLQMTSNQAIKF-----HRT-IH------IRVAQLNRRYM------FCCLFLATVYYSV----LL------SNPHF-YL------VKQFR-L----YSLAWSIVA------VIVAFTVAGKYFAIIGYLTLIQVYYLFRLRSA------VELA-DS-YRRL-K------CTDE------L-AST-----F-IKHTFECLNQSEKWVKSTGDFVLCVFTCVTMICDLFIFYGFIIRFHSP------LFANS-LASIGCIVFSVIGYLSLIAREF------IIKIERLCSHI-HSVSRC-N------VF--NVYNHFKLLQLMERLSEPKIGIQLGPIA-TIGKDFLIRFMLEIGSSLML---FTLNFKRFF------TuGR142/1-455 MRRSK---HLIVNKFLNLV------NGLHLYDRLK------M------NLF------SQWPHYS------LS------SFK---SKLINL------LLG-L------PNH-TLKSE------ETIEQLVKF--EKFSIFFR-AS-RFGFAQ---NVSHQSA------KTDYYSLI---MRAIGQINLIRLICLIA-I------YNEDYQLYLGDVAYKTKH-RS---MVNTLFTMCFLFGA--VNSEWLV---LYDKRGNYSF-L------AIYS------DIIKHG-FE--PVHLQMTSNQAIKF-----HRT-IH------ILVTQLHRSFI------FCFIFLAAVYYSV----LL------FNPHF-YL------VKQLP-F----YCLAWSLVA------IIVTFTLIGKYFAIFGYLILVQLYHLFRLKSV------VELA-DL-YRNT-K------CTDQ------L-AST-----L-AKHAFVCLNELEKCAKLTRYIVLCVFTIVAFNCDIFIFYGFIMRFHSP------LYANS-LGSIGCIVFIVIVYLSFIAREF------IIKNERLYFHI-RTMCRH-N------VF--NTCNQFKILQLMERLSDPNNGIQLGSIT-TIGKDFFIRFMVEIGSSLML---FTCNFKRYFEQ------TuGR141/1-427 ------M------KLF------NHCQHYS------LS------SFK---IKLINL------LLG-L------PND-SLTSK------ETVEQLVKF--EKLSIFFR-AS-RFGFNQ---NESHQST------KTDYFSLI---VRAIGQINLIRLVCLTI-I------DDEDYQLYLGDVAYKTKH-RS---MVNVLFAICFLIGV--VNSELIF---LYDKSGKYSV-L------TIYS------EIIKNG-FD--PVHLQMTSNQAIKF-----HRT-IH------ILINQLNRNFI------FCCLFIGPGYYSI----LL------LNLNF-YK------VKEFQ-F----YSLAWSLVA------IITTIIVIGKYFAIFGYLISIQVYHLFRLKSI------VELA-NS-YRSS-E------CTDE------H-VST-----L-TKHTFVCLNDSEKCAKLTRNIVLCVFTVIAFVCDLFIFYGFIIRFHSP------LFANS-VGSIGCIGFIIIGFLSFIAREF------IIKIDRLYSHL-RAICRY-N------VF--NVYSQFKLLQLMERIFEPNNGIQFGSIT-RIGKDFFVTFMVEIGSSLIL---FTLNFKRYF------TuGR143/1-435 ------MYSIHELK------M------KLV------NHCQHYS------LS------SFK---IKLINL------LLG-L------PNH-RLTSE------ETIKQLVKF--EKFSIFFR-SS-RFGFNQ---NVSHQST------ETDYLSLI---MRAIGQINLIRLICLTV-I------DNEDYQLYLGDIAYKTKH-RT---MVNILFTVCFLIGV--VTNEWLV---SYDKSGKYSV-L------TIYS------DIINNG-FD--PVHLQMTSNQAIKF-----HRT-IH------ILITQLNRNFL------FCCLFLAICYYFM----LL------SNPHF-YQ------VKELV-F----YSLIWSLVA------IVPTFTMTGQNMGTLIYLILVQVYHLFRLNSV------VELA-DY-YRRL-K------CTDE------L-VKS-----L-IRHTFECLNQSERCAILTRAIVLYGFTVIALIGDLLTFYGLIIRFHSP------VFADL-SGSIGCLVFIVIGCLSYIAREF------KIKIDRLNSDF-HIICRY-N------VI--NAYNRLKIFQLMDRLNGPYNGIQLGQIT-TIGKDFFVVFMLEIGSSLML---FTCNFKRYF------TuGR139/1-447 ------MINFDSLRFG------GIFNLYNKLK------L------KLI------SQWQHIS------LS------ALK---IKLIKL------LSG-L------PDH-SSTPE------KTIEKLVKY--EKFSIFFG-AS-RVGFNQ---NVSHRPT------RTDYFGLT---MRIIGQINLARLICLTV-I------DNEDYQLYLGDIAYKTKH-RT---VVNFLLTVVFLFGV--INSEWLV---LYDKGGAFSG-L------SIYS------AIIKNG-FD--PVLLQMTSNQAIKF-----QRS-IH------ILITQLNRSFK------FCCLFLAARYFSI----LL------FNPNF-YQ------DKEFV-F----YSLVWSLIA------ISVTFTLIGKYFAIFGYLILIQVYHLVRLESV------VELA-DS-YRSS-K------FSNE------L-VSS-----F-TKYTFDSLNQSEKCFKRTGFLVLCIFTVIAFIGDLCIFYGFIIRFHSP------LFANS-VGSMGCVVFIIIGCLSFIAREF------IIKMERLYSHL-HVICPY-N------VF--NVYNQLKLLQLMERLSEPNNGIQLGSIA-TIGKDFFIRFMLEIGSSLML---FTLNFKRYF------TuGR136/1-443 ------MNV------DVFNPYNKMK------M------KLY------SKWRHYS------LS------SFK---SKLINL------LLG-L------PNH-SLTSE------DTIEQLVKF--EKFSIFFR-AS-RFGFNQ---NVSHRRA------KTDYYSLI---MRAIGQINLIRMICLIV-I------DDEDYQLYLGDFAYRTGY-RS---IINILVTLCFLLGV--VNSELIN---LYDKSGQFSA-V------KIYS------DIINHG-FD--PLILQMTKSQAIAF-----HRT-IH------ILVTQLNRSFI------SCCIFVQLCYYSL----LI------LNPHF-YQ------VKQLP-L----YSLAWSLVV------MFVAFTLLGKYFAIFGYLFSIQAYAFFRLCSA------VELA-DS-YRRF-RC------ITNE------F-APS-----F-IKFTFECLNQSEKCATLTRAIVLCVFTAIAFVGDLLIFYGFIMRFHSP------LFANS-LGSLGCVVFIVIACLSFIARQF------KIKLERSHTHL-QIIYRY-N------VF--NVYNQFKFLQLMERLSEPNNGIQLGSIT-TIGKDFFVVFMLEIGSSLML---FTCNFKQYFEH------TuGR137/1-443 ------MNNFLTFV------DSFHLYDNLK------L------KIS------SQWRHY------S------PFR---SKLINL------LLG-L------PNH-SLTPK------DTIEQLVKF--EKFSIICR-AA-RFGFKQ---NVSHQSA------KTDYFRLI---MRVIGQINLIRFICIIV-I------DNEDYQLYLGDFAYKTNY-RF---IINFLVTIIYLIGA--VNSECLV---LFDKSGKFSV-L------AIYS------SIIDHG-FD--PLILQMTKTQAIAF-----HRT-IH------ILVTQLNRSFI------FCCLFVKPCYFSI----LL------FNPNF-YL------VKQLP-Y----YSLAWSLVV------VFVSFTMIGQYFAIFGYLFLTQAYSFYRLRSA------IELS-DS-YRSS-K------FTNE------F-AST-----F-IKYTFDSLNQFEKFSKLTGIIVFSVIAAIAFMGDLCIFYGFIMRFHSP------LYANS-TGSIGCIVFIVIGCLSLIAREF------KIKMEHLNSHL-QIIYRY-N------VL--DVYNQFKLLQLMERLSEPKNGIQLGSIT-TIGKDFFMVFMMEIGSSLML---FTLNFKRYF------TuGR138/1-445 ------MNNFLPFV------DIFHWYNKLK------M------KLF------SKSRHYS------LS------PFK---ITIINL------LFG-L------PNH-SLTSE------ETIKQLVKF--EKFSIFFR-AS-RFGFNQ---NVSHQSA------KTDYFRLI---IRAIDQITLIRCICLTL-I------DNEDYQLYLGDFAYKTKY-RS---MINILMSISFSLGA--VNSELIV---LYDKSGKYSV-L------TIYS------DIIKNG-FD--PVHLQMTSNQAINF-----HRS-IH------ILVTQLNRSFI------FICFFVEPCYYTI----LL------FNPHF-YQ------VKPLP-Y----FSLAWSLVV------IFVAVALFGRYFAIFGYIFLIQAYSMHKLRSV------VELS-DS-YRRL-K------CTDE------L-AST-----F-IKYTFECLNQWEKSAHLTGALVFSAFAVIVPIGDLLIFYGFIVRFHSP------LFANS-VGSLGCIAFTVIGYLSLIGREF------IIKIERSYSNL-QIMCRY-N------AL--DVHNQFKLLQLMERLSDPNIGIQLGSII-TIRKDFFIKFMLEIGSSLML---FTMNFKRYF------TuGR117/1-428 ------M------INQ-----AFVKNVCIKTALF------IVG-L------PNE-DDHEE------ETIAAFYQW--CQLSIFFG-ST-MNGYKR---YSSA------TTNAIA--SFHRKNFL---IRFCNIISIIRLFILLL-Y------DNEVVSIFGGDPLFHSKQ-RV---LTISIIFIGLLTGF--FAREIFM---SLEAKSNTEI-Y------FCFE------CFLQSNG-FN--HLNLQMISSRAIIY-----RYI-VH------FFSIFWMRFMC------LCIPFLTILLNTT----II------VNPYF-YQ------IPSYT-I----FSIFWSIPL------TLAAIFNIVGFASISGYVIMSGLYYLNRLESI------CSTA-VH-ITEK-DRE------IEDK------F-VIS-----L-ILRFIGHSNDVDHFLNVLAFLILYYILAVSFIGNLLIFAGFIARLHSD------IIANM-CSFLGVFIMGLLAMACYTEGSF------LTKLHLLYEKL-HLISES------RL--KMKTKMKILEVMDRIIGPYNGVKAGDLA-TISKHFFVIFLLENASTLML---ITVNTRSLLE------TuGR118/1-428 ------M------INQ-----AFVKNVCIKTALF------IVG-L------PNE-DDHEE------ETIAAFYQW--CQLSIFFG-ST-MNGYKR---YSSA------TTNAIA--SFHRKNFL---IRFCNIISIIRLFILLL-Y------DNEVVSIFAGDPLFRSKQ-RF---LTLSIIFIGLLTGF--FAREIFM---SLEAKSNEEI-Y------FCFE------CFLQTNG-FS--HLNLQMISSRATIY-----RYI-VH------FFSIFWTRFMC------LSIPFLTILLNTT----II------VNPYF-YQ------IPCYT-I----SSIFWSIPL------TLACVFNIVGFASISGYCIISGLYYLNRLESI------CSIA-VQ-STEK-DRE------IEDK------F-VIS-----L-ILRFIGYSNDVDHFLNVLAFLVLYYILAVSFIGNLLIFAGFIARLHSD------IIANM-CSFLGVFIMGLLAMACYTEGSF------LTKLHLLYEKL-HLISES------RL--KMKTKMKILEVMDRIIGPYNGVKAGDLA-TISKHFFVIFLLENASTLML---ITVNTRSLLE------TuGR464/1-436 ------MVGWHKAI------M------IKL-----AFVKNVFIKTVLF------IVG-L------PNE-DDHGE------ETIAAFNQW--CRLSRLFG-ST-MNGYKR---YSSA------TPNTIS--SFNRKNFV---VRFCNIISMIRLLVLLL-Y------ENETVSTFAGDPVFRSKQ-RV---LAISIMFIGLVTGF--FSREIFL---SLEAKSSDEI-Y------FCFE------CFLQSNG-FN--HLNLQMTSSRAITH-----RYI-VH------FFSIFWTRFMC------FVIPFLTILLNTS----IL------VNPFF-YQ------IPIYT-I----FSIFWTIPF------TFAFVYNIVGFASISGFCIMSGLYYLNRLESI------CSIA-VH-TTNK-SRE------IEDE------F-VTS-----L-ILRFISHSNDVDHFLNVLAFLILYYILAISFLADLLIFAGFIARLHSD------IIANM-CSFLGVFIMGLLAMACYTEGSF------LTKLYLLYRKL-HLISES------RL--KMKTKMKILEVMDRIIGPYNGVKAGDLA-TISKYFFVIFILENASTLML---ITVNTRSLLE------TuGR552/1-437 M------KKVRWQKAI------M------VNL-----NFAKNVFIKTVLF------IVG-L------PNE-DDHGE------ETIAAFNQW--CRLSRLFG-ST-INGYKR---YSSA------TPNRIS--SFNRKNFL---IRFCNIISMIRLLVLLL-Y------ENETVSIFAGDPLFRSKH-RV---LAMSIVFIALVIGF--FSREIFL---SLEAKSNTEI-Y------FCFE------CFLQSND-FN--HLNLQMTPSRAITH-----RYI-VH------FFSIFWTRFMC------FVIPFLTILLNTT----II------VNPFF-YQ------IPSYA-I----FSIFWTIPF------TFAFVYNIVGFASISGYVIMSGLYYLNRLKSI------CSIA-VH-TTNK-SRE------IEDE------F-VTS-----L-ILRFIGHSNDVEHFLNVLSFLILYYILAISFLADLLIFAGF-ARVHSD------IIANM-CSFLGVFIMGLLAMACYTEGSF------LTKLHLLYEKL-HLISES------RL--KMKTKMKILEVMDRIIGPYNGVKAGDLA-TISKYFFVIFLLENASTLML---ITVNTRSFLE------TuGR120/1-428 ------M------INL-----DFVKNEFTKTVLF------IVG-L------PNE-DDPGE------ETILAFNQW--CRLSKLFG-ST-MNGYKR---YSSA------TPNTIS--SFDRKNFL---VRFCNIISMIRLLILLL-N------ENEAVSIFAGDPGFRVKQ-RV---LGLSIVFIGLVTGF--FSREIFL---SLEAKCSDEI-Y------FCFE------CFLQSNG-FN--HLNLEMTPSRATNH-----RYI-VH------FFSIFWTRFMC------FVIPFLTILLNTS----IL------VNPFF-YQ------IPIYA-I----FSIFWTIPF------TFAFVYNIVGFASISGYVIMSGLYYLNRLKSI------CSIA-VH-TTNK-SRE------IEDE------F-VIS-----L-ILRFIGHSNDVEHFLNVLAFLILYYILAISFLADLLIFAGFIARLHSD------IIANM-CSFLGVFIMGLLAMACYTEGSF------LTKLHLVYEKL-HLISES------RF--KMKTKMKILEVMDRIIGPYNGVKAGDLA-TISKHFFVIFILENASTLML---ITVNTRSLLE------TuGR119/1-439 ------MVGWQKTI------M------MSL-----AFVKNIFIKTVLF------IVG-L------PNG-DEHEE------VTIAAFNQW--CRLSRLFG-ST-MNGYKC---YSSA------TPNTIS--SFNRKNFL---IRFCNIISIIRLVILLL-Y------ENETVSIFGGDPVFRSKK-RI---LEIFIIFIGLVIGF--LAREIFL---SLEAKLSEKM-F------FCFQ------CFLQSNG-FN--HLNLQMNPSRAIAF-----RYL-VH------FFSFFWTRFMC------LCIPFLPILLNTT----II------INPYF-YQ------IPCYT-I----SSILWSIPL------TLAFVFNVVGFASISGYCIISGLFYLNRLESI------CSIA-VD-ATAK-DNE------IEEQ------F-VIS-----L-ILKFISHSNNVERFLNVLAFLILYYILAVSFIANLLIFAGCIARLYSD------VIADM-CSFLGGTIMAVLIIACYTEGSF------ITKLDLFYRKL-HLISES------GL--EMTTKMKILEAMDRIIGPYNGVKAGDLA-TISKHFFIIFLLENASFLML---ITVNTRSMLESTK------TuGR147/1-434 ------M------LNYFSKYLK-----YLQFWK------HIYSY------LTT-I------PDS-NEFDR------KVSDLVRRI--ERLTINFQ-VV-RKGLHQ---TNIP------TVNAFGYRRLNLLDWI---IAVASLAVVFRFTVLIF-N------TNETIAIYLGDFFLHGKA-RV---LCESYFAFAISIAF--TCREWIL---HLEAKGEFEV-L------SIWK------HCRDG-FN--LVNLSMNNRNIKRF-----RFS-IY------FFSLMFYNMVI------LVPIVVSVLFITT----LL------TNPWT-YK------IPEFA-I----FGTIWLLLT------IFVSTILLSSVLGFAWFILCAFSFHLFRLFDL------LDAA-ET-LLNR-S--MF------YTEK------D-IQS-----L-CLLIIRRLNSFELASRKLRYILLIYVLVYSLLGNGDIFLGLIVRAYNG------FFANL-LAMIGIFILTAPGIFGFVFGYP------ITEIDKLTVRL-HRLTFK-G------NF--SVDTMCKVLEIMNRAAGPYNGVKIGDFI-TLEKTFFILFILENISTLML---FTVNIGPMSAT------TuGR145/1-446 ------M------TENEKS------DKKK------QNFILKYLT-----SLQFWK------QVFLY------LTT-I------PDS-NEFDQ------KVSGLVRRT--ERLAITFQ-VV-RKGLNQ---TNIP------TVNESGYRRFNMVDWI---IAVASLAVVFRFTVLIF-N------TNETIAIYLGDTFLHGKD-RF---LCESYFAFAISIAF--TCREWIL---HLEAKGEFEV-L------SIWK------HCRDG-FK--AVNLRMNNRNIKRF-----RSS-IY------FFSVIFYNMLI------SVPIIVSVLFFTA----LL------INPWT-YK------IPEFA-I----FGIIWLLLT------IFVSTILLSSVLGFAWFILCAFAFHLFQLLDL------LDSA-EI-LLNR-S--ML------YTEK------H-IQS-----F-CLLIIRRLNSFELASRKLKYVLLCYTFVYSLLGNGDIFLGLIVRSYSD------IFADL-LAIIGTFILIAPGVFGLVFGYL------ITELDKLTVRL-HRLTSK-G------NF--SVKTMSKVMEIMDRVAGPYNGVKIGDFT-TVDKTFFILFILENISILML---FTVNIRPLSATYR------TuGR146/1-447 ------M------L------TVNAKS------GMKM------ENYISKYLN-----YLQFWK------HIFSY------LTT-I------PDT-NEFDQ------KVSDLVRRS--ERLTITYQ-VV-RRGLDQ---TNIP------TVNEFGYRRFNMVDWI---IAVASLAVVSRFAVLTF-S------TNETIAIYLGDTFLHGKD-RF---LCESYLAIALSLAF--GCREWIL---HLEAKGQFEV-L------AIWK------HCRDG-FK--VVNLRMNSRNIKRF-----RFC-IY------FFSIIFYNMLI------SVPIMLSILFVTT----LL------TNPWT-YK------IPEFA-I----FGTIWLLLT------IFVSTILLSSVLGFAWFILCAFAFHLFRLLDL------LDSA-ET-LLNR-SYNML------YTEK------D-FQL-----F-CLLIISRLNSFELASRKLRYVLLCYVFIYSLLGNGDIFLGLIVRAYND------IFADS-LATIGTSILIAPGVFGVLFGYL------ITELDKLTVRL-HRLTFK-G------NF--SVNTMSKVLEIMDRVAGPYNGVKIGDFT-TVDKTFFIIFILENISILML---FTVNIRPLSVT------TuGR148/1-448 ------MKTN----V------ECNAKS------VEKM------LNYFFKYLK-----YLKYWR------QIFSY------LTT-I------PDS-NEFDQ------KVSDLVRRT--ERLAIAFQ-AV-RRGLNQ---TNIP------TVNEFGYRRLNLLDWI---IAITSVATIFRYTVLIF-N------TNETIAIYLGDSFFHSED-RA---LILSLFAISTSLAF--AFREWIL---HLEAKGKFEV-L------SIWK------DNRDG-FN--LVNLRMNNRNIKRF-----RFC-IY------FLSVMIYYMML------LIPIFMSFLFFTP----LL------INPWT-YK------IPALA-F----FATGWLLLA------IFVGAFLFNSILGFAWLFLSVLAFHLFRLFDL------LDSA-ET-LLNR-S--MF------YTEK------D-FQL-----F-CLLIISRLNSFELASRKLRYIFSCYVFVYSLLGDVAIFLGLIVRAYND------FFADL-LAILGLFTLGFLGIFGFVFGYL------ITELDRLTIRL-HRLTFK-G------KF--SVKTMSKVMEIMDRVAGPYNGLKIGDFF-TLEKRFFILFIMENLSILML---FTVNIGPMSVT------TuGR149/1-446 ------M------L------TVNTKS------VKKM------IDYFLKYLKY----YLKFWK------QIFSY------LTT-I------PDA-AEFDR------KVSNLVRRT--ERLAITFQ-AV-RRGLDQ---TNIP------TVNEFGYRRLNVLDWV---IAITSVVNVFRFTVLIF-N------TNETIAIYLGDSFLHSKD-RV---LCLSFFAIAMSIAF--TFREWIL---HLEAKGKFEV-L------SIWK------DNRDG-FN--LVNLRMNNRNIKRF-----RFC-VY------FLSVMIYYMML------LIPIFMSFLFFTP----LL------INPWT-YE------IPALA-F----FATIWLLLA------IFVGTFLFNSILGFAWFILCALAFHLFRLFDL------LDSA-KN-LLNR-S--MF------YTEK------D-FQL-----F-CLLIISRLNSFELASRKLRYVLLCYAFVYSLVGDGNIFLGLIVRAYND------FFADL-LAIIGLFILCFLGIFGFVFGYL------ITELDKLTIRL-HRLTFK-G------KF--SVKIMSKVMEIMDRVAGPYNGVKIGDFF-TLEKRFLILFIMENLSILML---FTVNIGPLIQT------TuGR150/1-446 ------M------L------TVNKKS------VKKM------LNYFLKYLKY----YLKFWE------QIFSY------LTT-I------PDS-KEFDR------KVSDLVRRT--ERLAITFQ-AV-RRGLDQ---TNIP------TVNAFGYRRLNLLDWI---IAITSLATVFRFTVLIF-S------TNENIAIYLGDSFLHSKD-RV---LILSLFAIAIALAF--TFREWIL---HLEAKGQFEV-L------SIWK------DNRDG-FN--LINLRMNNRNIKRF-----RFC-VY------SFSVIFYHMVI------SAPIFITFLFSTP----LL------INPWT-YK------IPGLA-I----FGTIWSFLS------IFVGTIVLNSILGFAWFILCAFSFHLFRLFDL------LDSA-ET-FLNR-S--MF------YTEK------D-MQS-----F-CLLIIQRLNTFELASRKLRYIVLFYVFVYSLLGDADIFLGLIVRAYSD------FFADL-LAIIGVFILIALGVFGLVFGYL------VKELDKLTVRL-HRLTFK-G------NF--SVNTMSKVFEIMDRVAGPYNGVKIGDFI-TLEKTFLILFIMENISILML---FTVNIGPLSVT------TuGR151/1-440 ------M------VAIIKSL------DFKV------KVYFLKN------LK------QLCSY------LIA-I------PDS-SEFDS------KVWDLVRRT--ERLTIIFQ-VV-RNGLSQ---TNIN------SVNAFGYRRLKLIDWI---IAITSLVNSLRFMVLFF-N------TNDDIAFYLGDPLFRSKD-RL---PLLTWAAMAIAIMF--TFREWIL---YLEARGKFEV-L------SIWM------VCLDG-FN--LVNLRMNNRNIKRF-----RFS-IY------FVSLVFSNVMT------VVPIFLSILFFTP----IL------TNPWT-YK------IPKLA-F----FGIVWSFSV------IFAITFILNSILGFGWFVLCALPFHLFRLLDL------LDLA-DF-LLHK-TNALT------YTEK------D-IQT-----F-CSLIISRLNSFELAASKLRYVLLCYVFVYSLAGDVYIFLGVIVRVYNN------FFANL-LATIGIFILPIIGLFGLVFGNL------VTELDKLTIRL-HRLTFK-G------KF--SVNTMSKVMEIMNRVSGPYNGVKVGDFL-TLEKTFFILFILENISTLML---FTCNIGPLID------TuGR659/1-440 ------M------VANAKSL------DFKV------KVYFLKN------LK------QLCSY------LIA-I------PDS-NEFDS------KVWDLVRRT--ERLTIIFQ-VV-RNGLSQ---TNIN------SVNAFGYRRLKLIDWI---IAITSLVNSLRFTVLFF-N------TNDDIAFYLGDPLFRSKD-RL---PLLTWAAMAIAIMF--TFREWIL---YLEAKGKFEV-L------SIWK------VCRDG-FN--LVNLRMNNRNIKRF-----RFS-IY------FVSLVFSNVMI------VVPIFLSILFFTP----IF------TNPWT-YK------IPKLA-F----FGIVWSFSV------IFAITFILNSILGFGWFVLCALTFHLFRLLDL------LDLA-DF-LLHK-TNALT------YTEK------D-IQT-----F-CCLIISRLNSFELAASKLRYILLCYVFVYSLAGDVYIFLGVIVRVYNN------FFANL-LATIGIFILPIIGLFGLVFGNL------VTELDKLTIRL-HRLTFK-G------KF--SVNTMSKVMEIMNRVAGPYNGVKIGDFL-TLEKTFFILFILENISTLML---FTCNIGPLID------TuGR152/1-444 ------M------M------PVNGKSFY------NVYKM------LEHFSKN------FK------QIVSS------LKA-I------PDS-NEFSS------QVWDYVRRT--ERLTINFQ-VV-RNGLDQ---TDIK------TVNAFGYRRLNLIDWV---IFITSLANVLRISVLIF-N------TNDTVSFYLGDPLFQSKD-QL---PLITWCGLAIFVNF--IFREWIL---YLEANGKLKV-L------SIWK------EYRDG-VK--LVDLRMSNRNIKQF-----RFS-VY------CVSLVFNNVMI------GLPIFLSILFFTP----LL------TNPWT-YK------VPKLA-F----FGIIWSFSV------IFAVTYLLNSILGFAWYILCVFTFHLFRLLDL------VDFA-DF-LLKQ-TNENL------CNEK------D-IQF-----F-SLLVIRRLNSFELASFKLRYIFLCYVIVYSAAGDVYIFLGVVVRVYSN------FFADL-VAIFGIFILPTLGFFGLAFGKL------ITELDRLTIRL-HRLTIR-S------KF--SINTMSKVLEIMDRVAGPYNGVKIGDFL-TLEKTFFILFILENITTLML---ITINVRPLIST------TuGR658/1-443 ------M------M------PVIAKSFY------NVYKM------LENFFKN------LK------QFFSY------LKT-I------PDS-SEFDS------KVWDYVRRT--ERLTINFQ-VV-RNGLNQ---TDT------NVNRLRYRRLNWVDWI---IAINSLVNVLRATLLIF-N------TNDTIAFYLGDPFFRSKD-RL---PLLTWCALTIFVNF--IFREWIL---YLEAKGKLKV-L------SIWK------EYRDG-AK--LANLRMSNRNMKRF-----RFS-IY------FVSLVFHNVMI------GLPIFLSFLFFTP----IL------TNPCT-YK------VPKLA-F----FGIIWSFSV------IFAVTFLLNSILGFGWYILCVLIFHLFRLLDL------LDFA-DF-LLKQ-TNKNL------YTEK------D-IQF-----F-SLLVIRRLNSFELAAFKLRYIFLCYVIVYSAAGDVYIFLGVIVRVYSN------FFADL-VAIFGIFILPTLGFFGLAFGKL------ITELDKLTIKL-HQLTIR-G------KF--SVNTMSKVLEIMDRVAGPYNGVKIGDFI-TLEKTFFILFILENITTLML---ITINVRPLIST------TuGR153/1-441 ------M------M------NDNCVN------SKHQ------NNFLSKN------LL------QRFSQ------ALS-I------PDT-NEFDE------KVCNLVRQT--EKLTIIFQ-VV-RSGLDQ---TNIP------TLNTFGYRRLKLIDWI---ITLTSLANLLRLVILIF-N------ADEPLAFYLGDPLFRSKG-RL---PCLTWVSIGIIISV--LVREFIL---YLEATGTFDV-L------SIWK------ACRDG-FN--QDNLRMNNRNIKRF-----RLS-VY------LISLNFHNVMI------GIPIFLLILFFTP----LL------TNPWT-YK------VPRLA-F----FGSFWSITL------VWQSIYLFDSVIGFAWYILCALAFHLFQLFDL------LDSA-DL-LLNK-TEKML------CTDK------E-IQS-----F-CLLIIRRLNSFELASRKLRYILLVYVLVYSFMGDVYIFLGVIVRVYSD------FLANL-IAIIGIFILPLLGFFGLVFGNC------ITKLDKLMIRL-HQLTLK-R------KL--SRSTMSKIWEIMDRVAGPYNGVKVGDFL-TLEKTFFILFILENISTLML---FTVNIGPLIEQ------TuGR154/1-441 ------M------M------AVNSAN------SRRQ------KVFSLKN------WK------QISLY------LTS-I------PDS-KEFDS------KVCRLVRQT--ERLTIIFQ-VV-RNGLDQ---TNIP------TLNAFGYRRLKLIDWI---ITLTSLANLLRLVVLIF-N------ADEPLAFYLGDPLFRSKG-RL---PCLTWVSIGITMSV--LVREFIL---YLEATGTFDV-L------SIWK------VCRDG-FN--PVNLHMNKHNIKRF-----RFS-VY------LVSIIFHNVMI------GLPIFLSILFFTP----LL------TNPWT-YE------IPRLA-F----FGTFWSITL------VWQSIYLFDSVIGFAWYFLCALAFHLFQLFDL------LTSA-DL-LLNK-SKQML------CTEK------D-IQS-----F-CSLIIRRLNSFELASRKLRYILLVYVLVYSAAGDVYIFLGVIVRVYSD------FLANL-IAIIGIFILPLLGLFGLVFGSL------ITELDKLMIRL-HQLTLK-S------KL--SRSTMSKVWEIMYRVDGPHNGVKIGDFL-TLEKTFFILFILENISTLML---FTVNIGPMIEQ------TuGR657/1-442 ------M------M------DVAAKRV------DNKI------LNYFSNY------LN------AISSY------FIA-I------LDS-NALRS------KVRNIVRRT--ERLTIIFQ-VV-RIGFNQ---TNIP------YLNAIGYRRLKLMDWV---IAFVSLVNVLRMTVLIF-N------TNETVAIYLGDFFFRSKD-RI---ACLTWTSMAIAIMF--AFREWVL---NLEAKGKLQV-L------SICN------DYKDG-FN--LITRRMRNRNIQRF-----RST-IF------FVSLILYYAMV------TVPIFMTILFFTP----LL------TNPWT-YK------IPRLA-F----FGTFWLFSV------IFAAAFLLNHILGFGWYILCAFSFHLFQFLDL------LDWA-NL-LLEN-NNVLK------YTEK------D-IQS-----F-CLLIIRRLNSFEMASFKLRYVIFSYVIGYSFVGDIYIFLGVIVRVYSD------FLANL-LTIIGVFILPTIGVFGFVLGNF------ITELDKLTIRL-HQLTII-G------KF--SVNTMSKIMEIMDRVAGPYNGVKIGDFI-TLEKTFFILFILENISTLML---FTVNIGPLISK------TuGR157/1-438 ------M------SINERSV------FVAI------RDYFLK------LK------QILSD------SVT-V------PDS-HEFDA------NVRDLVRRT--ERLTIIFQ-VV-RSGLNQ---TDIP------NVNKFGYRRLNLVDWI---ILLTSLANLLRIFVLIF-N------ADEPLAFYLGDSLFRSKD-RL---PYLTLIAMSILMMA--PVREWIL---YLEAKGELKV-L------SIWK------DYRDG-CD--LDKFCMNRLKIRRF-----RFS-IY------LVSLIYCNVMI------MAPIFTATAFFIP----LL------TNPWT-YK------IPRLA-I----YGTIWAFSL------IITVTYLLNSLFGFGWFILCTFSFHLFRLLDL------LDRA-SF-LLNN-TNASI------YTEK------D-VRS-----F-CLLIISRLNSFELASFKLRYVLLYSVFAFSLFNDVFIFLGAIIRIYND------TLANL-ITIFGIIVLSIFGISGLILGNF------ITKLYNLTIRL-HQITIM-R------NF--SLNTMSKVWEIMNRVAGPYNGVKIGDFL-TVDKTFFILFVLENISILML---ITVNVRPLI------TuGR155/1-438 ------M------AMNEKSV------SIKI------RDSFLD------LQ------HFLSD------SIA-I------PDS-HEFDA------KVRDLVRRT--ERLTIVFQ-VV-RNGLNQ---TDVP------NVNAFGYRHLNLVDWI---IAITSLANLFRLFVLIF-I------ADEPISIYFGDFFFRSKD-RL---PCLSLCAMAIVMMV--TVREWVL---YFEAKGKLKV-L------SIWK------DYRDG-AN--LDKLCMKKLNIKRF-----RFT-IY------FASLIFYYVMI------VVPFFMTFLFFTP----LL------TNPWT-YK------IPRLA-F----YGTIWTFSL------IIACTFLLNFLYGFGWFILCTFSFHLFWLLDL------LDRA-GF-LLNK-TNAII------YTEK------D-VRT-----F-CLLIIHRLNSFELTSRKLRYLMLHNVLVYSVLADVYIFLGVIVRVYND------IVANS-IAISGISALMAIGLSGLILGNL------IGKLDSLTIRL-HQITIM-R------KF--SLNTMSKALEIMDRVAGPYNGVKVGDFI-TIDKTFFILFILENISTLML---ITINVRPLI------TuGR156/1-457 M------LFNSKASSL------FTLISKKEV------M------AISEKSV------SIKI------RDYFLK------FK------QILSD------SIA-I------PDS-HEFDA------KVRDLVRRT--ERLTIIFQ-VV-RNGLNQ---TDIP------NVNKFGYRRLNSVDWI---IALTSLANLLRIFVLFH-N------ADEPIAFYLGDPLFRSKD-RL---PCLALCAMVIVIML--PAREWVL---YLEAKGKLKV-L------SIWK------DYRDG-AN--LDKLCMNKLKIRRF-----RFS-IY------LLSLIFCYVMI------IVPIFMTIVFFTP----LL------TNPWT-YK------IPRLA-F----YGTIWTVPL------VITITYLVNSLFGFGWFILCTYEFHLFRLLDT------LDRA-GI-LLNK-TNVII------HNEK------D-VRT-----F-CLLIIRRLNSFELASRKLRYVLLYNVFVYSLLGDVYIFLGVIIRIYND------ILANM-LAILGIYILCLIGISGLILGNL------ITKLDNLTIRM-HQLTIM-R------KF--SVNTMSKALEVMDRVAGPYNGVKVGDFL-TVDKTFFILFILENISTLML---ITVNVRPLI------TuGR565/1-438 ------M------AISEKRV------SIKI------RENFLK------LK------KILSD------SIA-I------PDS-HEFDA------KVRDLVRRT--DRLTIIFQ-VV-RNGLNQ---IDIP------NVNTFGYRRLNSVDWI---IALTSLANLLRIFVLIF-N------ANEPLAFYLGDPLFRSKD-RL---PCLALCAMVIVIML--PARECLL---YLEAKGKLQV-L------SVCK------DYRNG-AN--LDKLCMNELKIRRF-----RFS-IY------LLSLIFYYVMI------ILPIFVTIVFFTP----LL------TNPWT-YK------IPRLA-F----YGTIWTLSL------IITFTFLVNSLFGFGWLMLCTFSFHLFRLLDL------LDRA-GF-LLNK-TNAIN------CTEK------D-VQS-----F-CLLMIRRLNSFGLASRKLRYLLLYNVLVYSLSGDIYIFLGFIVRIYNN------LLANM-LAISGIYILSLIGISGLMLGNL------ITKLYNLTIRL-HQITIM-R------KF--SVNTMSKVLEIMDRVAGPYNGVKIGDFL-TIDKTFFILFILENISTVML---ITVNVRPLI------TuGR574/1-443 ------MQMRI------M------AESTESF------VSIG------KKY-LKD------LA------NLFRY------SFV-A------PNS-IEVDL------RASQLLKRT--ERLTIIFQ-VL-RNGLDQ---NNSI------NVNTFGYRQYNCLDWI---IGITSLINWLRALILIC-T------SSETVAIILGDPLFRSKD-RQ---IIILCALNILTTMI--IFREWIL---SFEAKGDLKI-L------SIWK------FCRNS-FD--PVHLQMNNLNINRF-----RLI-VI------CVSIVAYCTML------VAPLFLSVTYFTV----IL------CNPWM-FK------IPELA-F----YCFLWSLSN------IFISSFLLNSILGFSWYLLCTLSFHLYRSIDL------LNKA-DY-LKNL-TK-GA------LNER------K-INL-----F-SLIIIRRLNSFELTASKLRYILFYYVFVFASLGDVYIFFGLVVRVYND------FFADL-VATLGIFILPSIGIFGLIFGNF------ISALDKLIVRL-HQLTLN-N------RL--TLKTSSKVLEVMDRVAGPYNDIKLGDFL-TIEKSFFIFFILENISTLML---LTVNIGPLIN------TuGR160/1-458 ------MQMRI------M------AESTESL------GSIG------KKY-LKD------LA------NLFRY------SFV-A------PDY-IEVDL------RASQLVKRT--ERLTIKFQ-VL-RNGLNQ---NDSI------NVNTFGYRRYNWLDWI---IGITSLINWLRALILIY-T------SSETLAIILGDPLFRSKD-RQ---IIILCALTILSTMI--IFREWIL---NLEAKGNLKI-L------SIWK------CCRNG-FD--PVHLQMNNVNTSRF-----RLI-VI------CVSIVAYCTML------VSPLFLSVTYFTV----IL------CNPWM-YK------IPELA-F----YCFFWSLSN------IFISSFLLNAILGFSWYLLCTLSFHLYRLIDL------LNTA-DY-LINS-TK-GA------LNER------K-IKL-----F-SLIIIRRLNSFELTASKLRYILFYYVFVFASFGDVYIFLGIIVRVYND------FFADL-VATLGIFILPSIGVFGLIFGNF------ISALDKLIVRL-NQLTLN-N------RL--SLKTSSKVLEVMDRVAGPYNGIKLGDFL-TIEKSFFIFFILENISTLML---FTVNIGPLINRYINKYS---NKAS------ISS------M TuGR620/1-443 ------MEMKI------I------ADSTES------SVQ------KNYFLKD------LA------NLFRY------SFV-T------PDH-NKVDL------CSAQLVQRT--ERLTIIFQ-VL-RNGLNQ---NNSI------DVNRFGYRRYNWLDWT---IGITSLINWFRCIVLIC-T------SSETLAICLGDPLFRSKD-RQ---IIILCALTILLTMI--IFREWIL---NLEAKGNLEI-F------SIWK------CCRNG-FD--PVHLQMNNVNIKRF-----RLI-VI------CVSIVAYCTML------VAPLFLSVGFFTV----IL------CNPWI-FE------IPELA-F----YCFLWSLSE------IFIASFLLNSILGFSWYLLCTLSFHLYRLMHL------LNTA-DY-LINS-TK-GA------LNER------K-IKL-----F-SLIIIRRLNSFESTARKLRYVLFYYVFVFASSGDVYIFLGIIVRVYND------FLADLIVALLGIFILPSIGVFGLIFGNF------ISELDKLTVRL-HQLALN-N------RL--SLNTSSKVLEVMNRVAGPYNGIKLGDFL-TIEKSFFIFFILENISTLML---FTVNIGPLIN------TuGR588/1-443 ------MEMKI------M------GDATESS------VSVR------KNYFLED------LV------NLFRY------SFI-T------PDS-DEVDL------CASHLIQRT--ERLTIIFQ-VL-RNGLDQ---NDSI------NVNTFGYRRYNLMDWI---IGITSLINWFRCIVLVC-T------SSVPVAIIFGDPLFRFKD-HQ---ISFIVILIMLSAMI--VFREWIL---NLEAQGNLEI-F------SIWK------SCRNG-FD--PVHLRMNNLNINRF-----RLI-VT------LVSLVVYCTML------LVPPFYSVGYLIP----LL------TNPWM-YK------MPELA-F----SCFFWSLSD------IFISSFLINAILGFTWYLLCTLSLHLYRLMDL------LDRA-DH-LKKL-PK--K------MNEK------H-IEF-----L-CLLMIRRLNSFELTARKLRYVLFYYAFVFASSGDVWIFLGIIVRVYND------FLADL-VAILGIFILPSIGVFGLIFGNF------ISGLDELTVRL-HHLTLN-N------RL--SLNTLSKVLEVMDRVAGPYNGLKIGDFL-TVEKSFFIFFILENISALML---FTINIGPLIN------TuGR593/1-440 ------MEMGI------M------ADTT------VTNR------KKIFLKD------FT------NSLRY------SFV-T------PDS-DVVDF------CVSQLVQRT--ERLTIIFQ-VL-RNGLNQ---NDSI------NVNTFGYRRYNRLDWI---IGILSLINWFRCIVLVY-N------KSETVSIILGDPLFQCKD-HQ---IAFIVILIMLPTLF--IGREWLL---NLEAQGNLEI-L------SIWK------FCRND-FN--PFHLQMNNLNINRF-----RLF-VT------LVSLVVYCSML------LVPPFYSVGFFIP----LL------TNPWM-YK------IPVLA-F----SSFIWSLSD------IFIASFLTNAILGFAWYLLCTFSLHLYRLIDL------LDRA-DQ-LKKS-FK--V------LNKR------Y-VEF-----L-CLLIIRRLNSFELTASRLRYVLFCYVFVFASASDVYIFLGIIVRVYND------FFADL-VAIIGFCILPSIGFFGLIFGNF------ISELDKLTVRL-HQLTLN-N------RL--SLSTLNKIWEVMDRVDGPYNGIKIGDFF-TLEKSFFIFFILENISFLIL---VTINIGPLII------TuGR623/1-438 ------MGI------M------ADTT------VNNR------KKIFLKD------FT------NSLRY------SFV-T------PDS-DVVDF------CVSQLVQRT--ERLTIIFQ-VL-RNGLNQ---NDSI------NVNTFGYRRYNRLDWI---IGILSLINWFRCIVLVS-N------KSETVSIILGDPLFQCKD-HQ---IAFIVILVMLPTLF--IGREWLL---NLEAKGNLEI-L------SIWK------FCRND-FN--PFHLQMNNLNINRF-----RLF-VT------LVSLVVYCSML------LVPPFYSVGFFIP----LL------TNPWM-YK------IPVLA-F----SSFIWSLSD------IFIASFLTNAILGFAWYLLCTFSLHLYRLIDL------LDRA-DQ-LKKS-FK--V------LNKR------Y-VEF-----L-CLLIIRRLNSFELTASRLRYVLFCYVFVFASASDVYIFLGLIVRVYND------FFADL-VAIIGFCILPSIGFFGLIFGNF------ISELDKLTVRL-HQLTLN-N------RL--SLSTLNKIWEVMDRVDGPYNGIKIGDFF-TLEKSFFIFFILENISFLIL---VTINIGPLII------TuGR581/1-443 ------MEIKT------M------ADSTESS------VSVQ------RNYFLKD------LA------NLFRY------SFV-T------PDP-NEVDL------CAAQLVKRT--ERLTMIFQ-VS-RNGFNQ---NNSI------K-NTLGYRRYNRLDWI---IGIISLINALRCIVLIC-D------SSETVAIILGDPLFRSKD-RQ---IIIIFALIFLFTMV--IFREVIL---SLEAKGDLNL-L------SVLL------SCRNG-FN--PFCLRMNDVNMNRF-----RLT-II------LVSIVAYCTML------VVPFFLSVGFFIP----FL------ANPWT-YK------IPELA-F----CGFLWSLSD------IFIATFLLNAILGFSWYFICALSFHLYRLMDL------LDKA-DY-LKKS-IK-VA------SNER------N-IKL-----L-SLLIIRRLNSFELATRKLRYVLFYYVFVFASSGDVYIFLGLIVRVHND------LLANL-LAVAGIFILPSIGVFGLAFGNL------ISKLDKLTVGL-HQLTLM-N------RL--SLSTSSKVLEVMNRAAGPYNGLKIGDFA-TLEKSFFILFIVENISILML---FTVNIGPLIN------TuGR594/1-439 ------M------AGATESS------ASNR------KNYFLVH------LA------NLFRY------SFV-T------PNP-NEVDF------CVSQLVQRT--ERLTIIFQ-VL-RNGLDQ---NELI------NVNTFGYRRYNWLDWI---IGIVSLINGLRCIVLIC-T------SSEAVTIILGDPLFRFKD-RQ---ICITVSFIILLALI--IFREWIL---TLEAKGSLEI-L------SIWK------YCRKD-FN--PVYLQMNEVNMNRF-----RLT-VI------LVSLVVYFTML------VVPVFLSVGFFTP----LL------TNPWM-YK------TPGLA-I----YCFLWSLSD------IFIASFLTNATLGFTWYLLCTLSLHLYRLTDL------LDRA-GH-LKKS-TK-GA------FNQR------D-IEL-----L-SLLIIYRLNSFELTASRLRYVLFYYVFVSASSGDLYIFLGLVVRIYND------FLANL-VAMIGIFILPSIGVFGLIFGKS------ASELDKLTVIL-HNLTLN-N------RL--SLNTLNKIWEVMDRVDGPYNGIKIGDFF-TLEKSFFIFFILENISTLML---FTVNIGPLLN------TuGR622/1-439 ------M------AGATESS------VSNR------KNYFLVH------LT------NLFRY------LIV-T------SNP-NEVVL------CVSQLVQRT--ERLTIIFQ-VL-RNGLDQ---NDFI------NVNTFGYRRYNWLDWI---IGIVSLINGLRCIVLIC-T------SSEAVTIILGDPLFRFKD-RQ---ICITVSFIVLLALI--IFREWIL---TLEAKGSLEI-L------SIWK------YCGKD-FN--PVYLQMNEVNINRF-----RLT-VI------LVSLVVYFTML------VVPVFLSVGFFTP----LL------TNPWM-YK------THGLV-I----YCFLWSLSD------IFIASFLTNATLGFTWYLLCTLSLHLYRLTDL------LDRA-GH-LKKS-TK-GA------FNQR------D-IEL-----L-SLLIIHRINSFELTASRLRYVLFYYVFVSASSGDLYIFLGLVVRIYND------FLANL-VAMIGVFILPSIGVFGLIFGKS------ASELDKLTVIL-HNLTLN-N------RL--SLNMLNKIWEVMERVDGPYNGIKIGDFF-TLEKSFFIFFILENISTLML---FTVNIGPLLN------TuGR591/1-443 ------MEMNL------M------VLSTKSS------KSVQ------KGYFLKD------LV------NLFRY------SFV-T------PDP-DKADL------CAAQIVQRT--ERLTIIFQ-VL-RNGLDQ---NNSS------NVNTFGYRRYNWLDWI---IAIVALINWFRCIGLIC-N------SSDTVNIILGDPLFRSKD-RL---ACIILAFITLTVLF--SFREWIL---SLENKGNIGT-L------SIWK------FCRYS-FN--PVYLEMDKLNVNRF-----RLI-VI------SVSVVSYCTIF------IGPLFASFVFIIP----LL------TNPWM-NK------IPELL-F----FCFLWSLSE------IFIASFLLSAVLGFSWYLICTFSFHSYRLLNL------IYKA-DY-LKNS-TA--A------VYAR------D-VQL-----L-CLLIIRRLNSFELAVRKVRYVILYICIVLTLLCDTFIFLGLIVRVYND------FLANL-LATVGIFGLPSIGVFGYIFGNF------ISELDKLTVRL-HRLALN-N------KL--SLKETSKVLEVMDRVAGPYNGLKVGDFL-TVERSFFIFYVLENITTLML---FTVNIGPLIK------TuGR161/1-442 ------MEIYK------M------VDFTESY------VSVR------KSYFLID------LA------NLFRY------SFV-T------PDP-NKVNM------CAAQLVQRT--ERLTIIFQ-VL-RNGLDQ---TNSI------K-NTFGYRRYNWLDWI---IGIISLITWFRCIVLIC-T------SSVSVGIILGDPLFRSKD-RL---ACIILAFITLTVLF--SFREWIL---SLETKGNLET-L------SIWK------FCRNG-FN--PVYLQMDKLNMNRF-----RLM-VI------SVSLVSYCTIL------FGPLFTSFVFITP----LL------TNPWM-YK------IPELV-F----SSFLWSLSE------IFIASFLLNAVLGFSWYLICTFVFHLYRLLNL------FFKA-DY-LKNS-TE--A------VYAR------D-IQL-----L-CLLIIRRLNSFELAVRKSRYVLLYIFIVLTLLCDTFIFLGLIVRVYND------FLASL-LATVGIFGLPCIGVFGYIFGNF------ISELDKLTVRL-HQVTLN-N------KL--SLKEMSKVLEVMDRVAGPYNGLKIGDFL-TIKKSFFIFFVLENISTLML---FTVNIGPLIK------TuGR590/1-437 ------M------NARVKS------AKPG------IVHLIGY------FK------RLFNN------PRT-I------PDT-NAFDQ------SVSELIRQT--ERMTIIFQ-AV-RNGLNQ---SNTV------AISSFGYRKLNWLDWM---VGIISFMNWSRGLILIF-T------SSERIAIFLGHPLFRAKD-RQ---ALTIWAVITLSVMF--IFREWIL---NLEAKGKLEI-L------SIWK------VCCNG-FN--RSHLKMGNLVINRF-----RLT-II------LVTIVAYCVMP------VVPLFTLVGFFTP----VL------TNPWM-YE------IPELA-F----SCFLGSFSC------ALITTFLLNSILGFTWYFICTLVFHLYRLMDL------LDRA-DR-LKKS-TRG------MNER------N-IKL-----L-CLLIIRRLNSFELTTRKLRYVFLYYFFVFASSGDVYIFLGLVVRIYND------VLANI-LALIGTIILPAIGIFGYIFGNF------LSELDELTVRL-HHLTSK-N------RL--SLKTLNKVSEIMDRVAGPYNGIKLGDFL-TIEKSFFIFFILENISTLML---FTCNIGPLIN------TuGR162/1-437 ------M------NARVKS------AKPG------IVHLIGY------FK------RLFNN------PRT-I------PDT-NAFDQ------SVSELIRQT--ERMTIIFQ-AV-RNGLNQ---SNTV------AISSFGYRKLNWLDWM---VGIISFMNWSRGLILIF-T------SSERIAIFLGHPLFRAKD-RQ---ALTIWAVITLSVMF--IFREWIL---SLEAKGKLEI-L------SVWK------VCCNG-FN--RTQLKMGNLHINRF-----RLT-II------LVTIVAYCVMP------VVPLFTLVGFFTP----VL------TNPWM-YE------IPELA-F----SCFLGSFSC------ALITTFLLNSILGFTWYFICTLVFHLYRLMDL------LDRA-GR-LKKS-TRG------MNER------N-IKL-----L-CLLIIRRLNSFELTTRKLRYVFLYYFFVFASSGDVYIFLGLVVRIYND------VLANI-LALIGTIILPAIGIFGYIFGNF------LSELDELTVRL-HHLTSK-N------RL--SLKTLNKVSEIMDRVAGPYNGIKLGDFL-TIEKSFFIFFILENISTLML---FTCNIGPLIN------TuGR592/1-444 ------MARLI------M------PNAVACY------YRYR------KNLLLEY------LR------NIFSF------FI-F------SHS-NDLDS------YVFQLIRRT--ERLTIIYQ-VL-RHGLSQ---SKPV------TAKSFGYRKLNRWDWI---IGITSLINWCRGLMLICNN------NSESVAIYLGDAIFRAKD-HQ---PLLIWLLVIYSILI--IFREWIL---ILESKGNLEV-L------SVWN------LCLNG-FT--PANLKMDNINCKKL-----RTA-II------IVSIFAYYMML------VFPLFISMLFIVP----LI------TNPWM-YK------IPKLF-F----TSFIWSFPC------SFNISFFLIGMIGFSWYLICLLSFHLYQLKNL------LNMA-DL-LNRS-TA-TI------SVDR------Q-VTL-----L-CLLAIRRLNSFEFAVKKLRYVFFYIVIVFAFSADVYVFLGGIIRIYND------ILANS-LVIIGVLMLSVIGAFAIAFESF------ISKLDKLTIKL-HQLSCK-N------KL--SLQTASKVLELMDRATGPYNGLKIGDFV-TLEKSFFILFILENISLLML---FTVNIGPLIK------TuGR597/1-443 ------MARLI------I------LHTFACY------YRYR------KNLLLKY------LR------NIFSF------FI-F------SHS-NDADS------YVFQLLRRT--ERLTIIYQ-VV-RHGLSQ---IKPV------TANSFSYRQLNRWDWI---IGITCLINWVRVLILIC-D------DSESVAIYLGDPLFRNKD-RR---PLFIWCLIILSIIV--IFREWIL---TLGYKGNLEI-L------HDWN------ICLNG-FT--SINLKMDNINCKRL-----RTT-II------LVSIFAYYTML------VGPLFLSMLIIAP----LL------TNPWM-YK------IPKLF-I----SSFIWSCSV------IFSCSVLLNGIVGFSWYLVCSLSFHLFRLTSL------LSMA-NL-LNRS-TG-TI------NVDR------E-VKL-----L-CLLATGRLNSFELTVKKLRYVSLYYVFVFAFSADAYIFLGGIVRVYND------ILANL-LAILGMIILSGIGGFAIAFGSF------ISKLENLTIKL-HQLSCK-N------KL--SLGTATKILELMDRAAGPYNGFKIGDFV-TLEKRFFILFIVENISLLML---FTVNIGPLIK------TuGR634/1-443 ------MARLI------I------LHTFACY------YRYR------KNLLLKY------LR------NIFSF------FI-F------SHS-NDADS------YVFQLIRRT--ERLTIIYQ-VV-RHGLSQ---SKPV------TANSIAYRQLNRWDRI---IGITCLINWVRVLILIC-D------DSESVAIYLGDPLFRNKD-RR---PLFIWCLIILSIIV--IFREWIL---TLGYKGNLEI-L------HDWN------ICLNG-FT--SINLKMDNINCKRL-----RTT-II------LVSIFAYYTIL------VGPLFLSMLIIAP----LL------TNPWM-YE------IPKLF-I----SSFIWSCSV------IFSCSVLLNGIVGFSWYLVCSLSFHLFRLTSL------LSMA-NL-LNRS-TG-TI------NVDR------E-VKL-----L-CLLATGRLNSFELTVKKLRYVSLYYVFVFAFSADAYIFLGGVVRVYND------ILANL-LAILGMIILSGIGGFAIAFGSF------ISKLDKLTIKL-HQLTCK-N------KL--SLGTASKILELMDRAAGPYNGFKIGDFV-TLEKRFFILFIVENISLLML---FTVNIGPLIK------TuGR624/1-516 MSVNLINNFKFQHRWLIMADTIASFYRNRKNCFLKSVQKIFSFFMISQLLNMKIISSNLTNSQLNTTRLI------M------PNTVTCY------YRYR------KNLLLKY------LR------NIFSF------FI-I------SHS-NDADS------YVFQLVRRT--ERLTIIYQ-VV-RHGLNQ---SKPV------TASSIGYRQLNRWDWI---IGITCLINWVRVLILIC-D------DSESVAIYLGDPLFRNKD-RR---PLFIMCFIILPIIV--IFRELIL---GLESKGNLEL-L------HVWN------VCLNG-FT--PIYLNMDNINCKKL-----RTT-II------IVSNFAHYAML------VVPLILSLLFIFP----FL------TNPWM-YK------IPKLF-F----TSFIWSFPS------IFSCSVLLNGMIGFSWYLICSLSFHLFRLTNL------LNVA-DL-LNKS-TG-TI------YVDR------E-VKL-----L-CLLAIRRLNSFEFAVEKLRYVFLYIVIVFAFSADVYIFLGGIIRIYND------ILANL-YAILGMIMLSGIGGFAIAFGSF------ISKLDSLTIKL-HQLSCK-N------KL--SLQTASKILELMDRAAGPYNGVKIGDFV-TLEKRFFILFIVENISLLML---FTVNIGPLISDGNRGFQ---V------TuGR632/1-446 ------M------ANTISSF------YRNR------KDCLLIS------LM------KIFSFFIIFS-HKFFI-C------SHS-NDVDS------YVFQSIRRT--ERLTLIYQ-VF-RHGLSR---SKPG------TVPSSGYRALNRLDWI---IGITCLINWFRALILIC-N------DSESVAIYLGDPLVRNKD-RR---TLIIWCFIILPIVA--IFRGWIL---SLESKGNLEL-L------HVWN------VCLNG-FT--PVHLKMDNINCKSL-----RTT-II------IVSIFAYYTML------VGPLFISMLFIVP----LL------TNPWV-YK------TPKLF-I----SSFIWSFPS------IFSVSFLLNGIIGFSWYLICSLSFHLFRLMGL------LNMA-DL-LNKS-TG-II------LVER------E-VES-----L-CLASIRRLNSFEFTVNKLRYVSLYYVFVFAFSADAYIFLGAIARVYNG------FIANL-LTILGLFMLSTIGAFAIAFGNF------ISKLEKLTIKL-HQLSCK-N------KF--SLGTASKISELMDRAAGPYNGLKIGDFV-TLEKRFFILFIVENISLLML---FTVNIGPLMK------TuGR166/1-438 ------M------EIK-QTM------SSLR------ERYFFKM------VE------TLFSY------LFT-I------LDP-NS-DS------TVSRLVRRT--ERLTILFQ-VV-RTGLNK---SNSA------NFNAYGYRRFNRMDLI---IWSLSLINIVRFTVLIF-N------PSDSVSFYLGDPLFRSKD-HQ---ILLIVATAAFIIMI--TFREWAL---AFEAKGKFHI-L------TVWS------VCRNS-FK--PNDLQLDKINVKRF-----RFL-VY------SISFIVYYFMM------FVPLFMAFIFFTL----LL------SNSWT-YK------IPELA-F----FGILWSIST------IFAISILFNSAIGQSWYLICSLSFHLFRLHHL------LDLV-NF-AVNR-SHHVI------LIDK------D-IRT-----F-CLITIRRLNDYEVAARQLRYLFLCYFFVFSFAGDIYIFLGLIVRVYSE------FFANL-LAILGFTILLAIGVFGFVFGNF------ISKLNELTIKL-HQLSAK-S------RL--SVPTASKVLELMDRVAGPYNGIKIGDFC-TLDKSFFIRFILENLSALML---FTINIGPLIQ------TuGR575/1-435 ------M------I------STKVLSF------LSKK------KNYGL------G------KLPSF------ASS-P------PKS-NGFDL------AVLRFVKRT--ERLIIVFQ-LD-FNGRSQ---SNSS------GVNTFGYRRYKWMDWF---ITINFLIYLIRFGAVSL-S------TSDSVAFCLGDILFRSKD-RQ---ILSMYSTISLTIMF--IFREWIL---NLNAKGRFEI-L------SAWR------VCFNG-FD--PINLQMNSIVAKRL-----RFT-IF------LHSIIAHNVML------SVPIFATCLFLVP----LL------SNPWT-YE------IPELA-F----FGLFWSIPS------IFLYTFLLNTATGFAWYNVCSICFHLFRLYDL------VHSA-DY-LNHW-P------ADEK------Q-LRS-----F-CVSIIRHLNNFEVLSHKFRYLQLSYFLVFAVAADFDLFLGIIVKIYSD------FFANL-FAILGFFILLGCGIFGLIFGNF------ISQLDKLTVKL-HQISMK-S------KL--RIRTANKVLEIMDRAAGPYNGLKVGDVV-TLEKSFFILFILENISTLML---FICTLGPLIEE------TuGR621/1-435 ------M------I------STKVFSF------LSKK------KNYGL------G------KLPSF------ASL-P------PKS-NGFDL------AVLRFVKRT--ERLIIVFQ-LD-FNGRSQ---SNSS------GVNTFGYRRYKWMDWF---ITINFLIYLIRFGVVSL-S------TSDSVAFYLGDILFRSKD-RQ---ILSMYSTISLTIMF--IFREWIL---NLNAKGRFEI-L------SAWR------VCFNG-FD--PINLQMNSIVAKRL-----RFT-IF------LHSIIAHNVML------SVPIFATCLFLVP----LL------SNPWT-YE------IPELA-L----FGLFWSIPS------IFLYTFLLNTATGFAWYNVCSICFHLFRLYDL------VHSA-DY-LNHW-P------ADEK------Q-LRS-----F-CVSIIRHLNNFEVLSHKFRYLQLSYFLVFAVAADFDLFLGIIVKIYSD------FFANL-FAILGFFILLGCGIFGLIFGNF------ISQLDKLTVKL-HQISMK-S------KL--RIRTANKVLEIMDRAAGPYNGLKVGDVV-TLEKSFFILFILENISTLML---FICTLGPLIEE------TuGR577/1-437 ------M------M------STKVSSF------LSKK------KNEVLRN------LE------KLSSF------SFT-S------PDS-NRLDS------TVVQFVKRT--ERLTFVFQ-LD-FNGRNR---SNSF------EVNTHGYRRYKWMDWF---ITINFLINLMRFSVLIY-G------SSDSVSFYLGDTLFHFKD-RH---VLLMYSTAAFVIMF--IFREWIL---NLNAKGKFEI-L------SAWR------VCFNG-FN--STNLQMNNLVAKRF-----RSA-IF------MYTIISHNVML------SVPLFAVCLFLIP----LI------SNPWT-YE------IPELA-F----FGLLWSIPT------IFLFTFLLNAVIGFAWYNVCSIYFDLFRLYDL------VHSA-DD-LNHW-P------VNEK------Q-VRS-----F-CVVIIRHLNNFEAISHKFRYLQLSYFIIFAVAADFDLFLGMIVKIYNE------FFANL-FTILGFFSLITLGTFGLIFGNF------ISQLDKLTMKL-HQLTTK-S------KF--SMSTSNKILEIMDRATGPYNGVKIGDFV-TLEKRFFVSFILENISILML---FICNIGPLIH------TuGR630/1-436 ------M------STKVSSF------LSKK------KNEVLRN------LE------KLSSF------SFT-S------PDS-NRLDS------TVVQFVKRT--ERLTFVFQ-LD-FNGRNR---SNSF------EVNTHGYRRYKWMDWF---ITINFLINLMRFSVLIY-G------SSDSVSFYLGDTLFHFKD-RQ---VLLMYSTAAFVIMF--IFREWIL---NLNAKGKFEI-L------SAWR------VCFNG-FN--STNLQMNNLVAKRF-----RSA-IF------MYTIISHNVML------SVPLFAVCLFLIP----LI------SNPWT-YE------IPELA-F----FGLLWSIPT------IFLFTFLLNAVIGFAWYNVCSIYFDLFRLYDL------VHSA-DD-LNHW-P------VNEK------Q-VRS-----F-CLVIIRHLNNFEAISHKFRYLQLSYFIIFAVAADFDLFLGMIVKIYNE------FFANL-FTILGFFSLITLGTFGLIFGNF------ISQLDKLTMKL-HQLTTK-S------KF--SMSTSNKILEIMDRATGPYNGVKIGDFV-TLEKRFFVSFILENISILML---FICNIGPLIH------TuGR579/1-447 ------M------TTIVLHA------LNKL------KKYIS------E------KLSSYQVCLRHIVAFT-V------PDS-NEFDL------AVCKLVKRT--EKLAIVFQ-LD-INGPSQ---RSVT------GVNAFGYRRYKWMDWL---ITINVLMSVTRFIVLTF-S------TSDSVAIYLGDPLFRVED-RQ---VLLVWFAMAMSIMF--IFREWIL---NLNAKGRFEI-L------STWK------VCCNG-FD--SSNLQMSNLVARRF-----RLT-IF------LFSIFVHNVML------LIPFFLSLLLLVC----TL------SNPWI-FK------MPKLA-F----FAFVLGSSS------IFVGDFLLAAVIGFFWYIACSIYFHLFRLYDL------LHCA-KD-LNHR-L------VGGK------Q-LGS-----F-CVSIIRHLNEFEAVSHKFRYLLLYYVSIFAAAGDFDIFLGMIVKVYND------FLANL-LTILGFFILLSSLAFSLIFGDF------ISQVNMLTVKL-HQLSTK-S------RL--TMGSANKVLEVMDRAAGPYNGIKIGDFV-TLEKSFAISFLLENMSILML---FICNIGPYLGSYKSSA------TuGR580/1-438 ------M------ATKVLTT------LNKQ------KKYIL------E------KFSSY------SFT-I------FNS-NEFDL------TVCKLLKRT--ERLTFVFQ-LD-FNGRSQ---SSS------AVNTLGYRRYKWMDWF---ITVNCLMNVIRFAVLSF-S------SSDSVAIYLGDPLFRVKD-RQ---ALLMWGAMAIAMMF--IFREWIL---NLNAKGSFEI-L------SAWK------VCFNG-FN--SADLQMNDLDAKRF-----RFT-IF------LFSIFSHNVML------FMPFFALFIFFIP----LL------SNPWT-YK------IPKLA-F----FGFGLSVSS------IFVFALLLNTVMGFFWYIVCSIYFYLFRLYDL------LNSA-ED-LNHQ-L------VDEK------Q-LGS-----F-CVSIIRHLNEVEAVSYKFRYLLLYYLSIFAAAGDFDLFIGMIVKVYND------FFANL-FAILGFLILVALGTFGLIFGNF------ISQLNKLTVKL-HQLSTR-S------RL--TLGSANKLLEIMDRTAGPYNGIKIGDFA-TLEKSFAISFILENISILML---FICNIGPSLESSKSSI------TuGR582/1-439 ------M------AKKPLNA------SRKQ------KKSVL------E------NLSSY------SFT-V------PDS-NEFDL------AVCKQVKRT--EKLTIVFQ-LD-FNGRSQ---SNSS------GVNAFGYRRYKWMDWF---ITINCLIHVIRFSLLTF-S------TSDYFAIYLGDPLFRVKD-RQ---ALLLWGALAAGLMF--VFRECVL---NLNAKGSFET-L------SAWK------VCFNG-FN--SSNLRMSNLVAKRF-----RFT-IF------LFSIFAYSVML------FFPFFALLLLFVP----LL------SNPWI-YE------IPELA-F----FGFAFSLPS------IFAFTFLLNSVIGFFWYIVCSIYFYLFRLYDL------LQSA-DD-LERQ-S------VDEK------Q-LQS-----L-CLEIIRHLNEFEAVSHKFRYLLLYYLSIFAVAGDFDLFLGMIVKIYND------FFANL-LAILGFLILLSLGVFGLIFGNF------ISQLNVLTVKL-HQLSVK-R------KL--TMCSPNKVQEVMDRAAGPYNGIKIGDFL-TLEKSFAISFILENISILML---FICNIGTSLESSNSSA------TuGR629/1-439 ------M------ATQALNA------SRKQ------KKTVL------E------KFSSY------SFT-V------PDS-NEFDL------AVCKQLKRT--EKLTIVFQ-LD-FNGRDQ---SKSV------AMNAFGYRRYKWMDWF---ITINCIIHVIRFSVLCF-N------TGDSVAIYLGDPLFRVKD-RQ---ALLVWGAMATGMMF--IFREWVL---NLNAKGSFEI-L------STWK------VCFNG-FD--STNLRMNNLVAKRF-----RFT-IF------LFSIFAYSVML------FIPLLSLLLIFVP----LA------SNPWI-YK------IPKLA-F----FGFLLSFTS------IFAFAFLLNTACGFFWYIVCSFYFYLFRLYDL------LQSA-NH-LHSQ-L------VDEM------Q-LRS-----L-SVEIIRSLNKFEAVSHKFRYLMLYYLSIFALAGDLDLFLGMIVNVYND------FFANL-LAILGFLILLSLGVFGLIFGNF------ISQLNMLTVKL-HQLSVK-S------RL--TMGSANKVLEVIDRAAGPYNGIKIGDFV-TLEKNFAITFILENISLLML---FICNIGPSLESSNSSA------TuGR596/1-438 ------M------VLNV------LSKQ------KNYVL------E------KLSSF------PFT-V------PNS-NEFDL------TVCKLVQRT--ERLTAFFQ-LD-FNGPSQ---SNSS------AVNAFGYRRYKWMDWF---ITINCLITYTKFVALGF-S------TSDSVAFYLGDSLFRAKD-GQ---AIYIYGSIMILMLF--IFREWIL---NLNAKGRFEI-L------SAWK------VCFNG-FD--STNLQMNNLVAKRF-----RFT-IF------LFSIFTQNVLL------SMPFCSALIYIIP----CL------SNPWI-YK------VPKLA-F----FCSVWSFPI------IFVFTLLFSTAFGFFWYIVCSICFHLFRLYDL------LHSA-DD-LIHR-L------VDGK------Q-LRS-----F-CVSIISHLNAFEVVSHKFRYLLLCYLLIFAAVGDFDIFLGTIVKVYNE------SVANL-FAFLGFSILLSLGTFGLIFGNF------ISKLNKLTVKL-HQLSTK-N------RL--TMRTANKVLEIMDRAAGPYNGIKIGDLL-TLEKSFGITFILENISALML---FICNIGPLIHTANLSNQ---N------TuGR163/1-438 ------M------ALNV------LSKQ------KNYVL------E------KLSSF------PFT-V------PNS-NEFDL------TVCKLVQRT--ERLTAFFQ-LD-FNGPSQ---SNSS------AVNAFGYRRYKWMDWF---ITINCLITYTKFVALGF-S------TSDSVAFYLGDSLFRAKD-GQ---AIYIYGSIMISMLF--VFREWIL---NLNAKGSFEI-L------SAWK------VCFNG-FD--STNLQMNNLVAKRF-----RFT-IF------LFSIFTQNVLL------SMPFCSALIYIIP----CL------SNPWI-YK------VPKLA-F----FCSVWSFPI------IFVFTLLFSTAFGFFWYIVCSICFHLFRLYDL------LHSA-DD-LNHR-L------VDGK------Q-LRS-----F-CVSIIHQLNNFEVVSHKFRYLLLCYLLIFAAVGDFDIFLGTIVKVYNE------SVANL-FAFLGFSILLSLGTFGLIFGNF------ISKLNRLTVKL-HQLSTK-N------RL--TMRTANMVLEIMDRAAGPYNGIKIGDLL-TLEKSFGITFILENISALML---FICNIGPLIHTANLSNQ---N------TuGR584/1-450 M------KQRMECKKT------M------VAKVRSV------LSKQ------KSFFRKI------Y------SFE-I------PDS-KEFDE------TVCNKIRQT--EKLTIFFQ-AV-RNGVNQ---SDSV------GVNTFGFRRFSWKDWL---ISISCFISVIRCGILGK-N------TNESVAIYLGDPLFRVKD-GH---VLLLWISVAILVTY--SFREWLL---VLEAKGKFKV-L------SVWN------ICCNG-FN--PVDLQMNKLNTKRF-----RFT-IY------LVSLTIYWVML------IIPLFCTLGSLSL----VL------TNPLM-YR------NPKLA-F----LALLWAPTL------SLSLTVVFSAIIGFGWYIMCSLYFHLYRLRDQ------IDCA-DI-LLNN-SKHGL------FAEK------D-IQL-----F-CSKVIQNLNNLEEASHKLRYVLLWYFSVLSSAFDFDLFIGTIIRVYNS------LLCNF-ATTAGFSVLISVGIFGHIFGSF------ITQLGRLTIRL-HQLSCK-N------KL--SMQSVSKVLEIMDRAAGPYNGIKIGDLL-TLEKRFFVSFILENISILML---FTVNIGPYFESYKSSA------TuGR585/1-444 M------RQRNEFKQI------M------AAKVRSV------LSKQ------KSFFQNK------Y------SFE-I------PDS-KEFDE------TVCNKIRQT--ERLTILFQ-IV-RNGLNQ---SDSV------EVNAFGFRRYNWMDWL---ITVSCLLTVIRCGILGR-N------TNDSVSIYLGDPLFRVKD-GH---VLLLWISVAVLVMY--LFREWLL---FLEAKGKFKV-L------SVWS------LCCNG-FN--PVDLQMNELNTKRF-----RFT-IY------LVSLTIYWIML------IIPLFCTLLSFSL----VL------SNPLM-YQ------NPKWA-F----FALLWSPTF------SFSLAITFFAIMGFGWYIMCSLYFHLYRLRDL------IDCA-DI-LLNN-SKHGL------FVEK------D-VQL-----F-CSKVIQNLNNFEVTSRKLRYVLLSYFFVISSGSDFDLFLGTIIRVYDS------LFCNL-LAIGGFSVLLSVGIFGLIFGSF------ITQLDRLTSRL-HQLSCR-N------KL--SMQSVSKVSEIMDRAAGPYNGLKIGDFV-TLEKRFFLRFIAENISILML---FTVNVGPLLH------TuGR586/1-444 M------RQRNEFNQI------M------AAKVRSV------LSKQ------KSFFQNK------Y------SFE-I------PDA-KEFDE------TVCNKIRQT--ERLTILFQ-IV-RNGLNQ---SDSV------EVNAFGFRRYNWMDWL---ITVSCLLTVIRCGILGR-N------TNDSVSIYLGDPLFRVKD-GH---VLLLWISVAVLVMY--LFREWLL---FLEAKGKFKV-L------SVWS------ICCDG-FN--PVDLQMNELNTKRF-----RFT-IY------LVSLTIYWIML------IIPLFCTLLSFSL----VL------SNPLM-YQ------NPKWA-F----FALLWSPTF------SFSLAITFFAIMGFGWYIMCSLYFHLYRLRDL------IDCA-DF-LLNN-SKHGL------FVEK------D-VQL-----F-CSKVIQNLNTFEVASHKLRYLLLWYFFVISSGSDFDLFLGTIIRVYDS------LFCNL-LATGSFSILLSVGIFGLVFGSF------ITQLDRLTIRL-HQLSCR-N------KL--SMQSVSKVLEIMDRAAGPYNGIKIGDFL-TLEKQFFILFIAENISILML---FTVNIGPLLH------TuGR165/1-444 M------KQRNEFKKI------M------AAKVRSV------LSQQ------KSFFQNK------Y------AFE-I------PDS-KEFDG------TVCNKIRQT--ERLTIFFQ-IV-RNGLNQ---SDSV------EVNTFGFRRFNWMDWL---ISVSCIITVIRCGILSK-N------TNDSVAIYLGDPLFRVKD-GH---VLLLWISVAILVMY--LFREWLL---TLEAKGKFKV-L------STWK------VCRNG-FN--PVDLQMNELNTKRF-----RFT-IY------LVSLTIYWIML------IIPLFCTLLSLSL----VL------ANPLI-YQ------NPELA-F----FALLWAPTF------GFSLAITFSAIMGFGWYIMCSLYFHLYRLRDL------IDCA-DL-LLNN-SKHGL------FIEK------D-IQL-----F-CSKVIKHLNTFEVTSYKLRYVLLCYFFVISSGSDFDLFLGTIIRVYNS------LFCNL-LATGALSILLSVGILGLIFGSF------ITQLGILTIKL-HQLSCR-N------KL--SMQSVSKVLEIMDRAAGPYNGLKIGDFV-TLEKRFFILFIAENISILML---FTVNIGPLLH------TuGR628/1-434 ------M------AAKVRSV------LSQQ------KSFFRKI------Y------SFE-I------PNS-KEFDE------TVCNKIRQT--ERLTIFFQ-IV-RNGLNQ---SDSV------EVNTFGFRRFNWLDWL---ITISCIITVIRCGILGK-N------TNDSVAIYLGDPLFRVKD-GH---VLLLWISVAILVMY--LFREWLL---TLEAKGKFKV-L------STWK------VCRNG-FN--PVDLQMNELNTKRF-----RFT-IY------LVSLTIYWVML------IFPPFCTLLSFSL----VL------ANPMM-YQ------NPKLA-F----FALLWSPTF------SLSLGFTINAIMGFGWYIMCSLYFHLYRLRDL------IDYA-DI-LLNN-SKHGL------FAEK------D-MQL-----F-CPKVIQHLNNFEAASFKLRYVLLCYFFVISCLCDFDIFLGTIIRIVNS------LFCNL-LAIGAFSILLSVGILGLIFGSF------LTKLGRLTVRL-HQLSCR-H------KL--SIQSVSKVSEIMDRAAGPYNGLKIGDFL-TLEKRFFILFIAENISILML---FTVNIGPLLH------TuGR587/1-434 ------M------FAKVKSL------LSKQ------KSFFRKI------Y------SFE-I------PDS-KEFDG------TVCNKIRQT--ERLTILFQ-IV-RNGLRQ---SDSV------EVNAFGFRRFNWMDWL---ISILCLINAIRCGILTQ-N------TNDAVAVYLGNIFFRDNK-GY---VLLLWCLVATIGLG--FFREWLM---TLEAKGKFKV-L------SVLN------VCRNG-FI--PVDLQMNELNTKRF-----RFT-VY------LVTLFVYITML------ATPLFCIFLYLSL----LL------SNPWA-DR------IDGLT-L----FSLLWLPVF------ILSLSTLLNTVMGFGWYIMCSLYFHLYRLRDL------IDCA-DF-LLNN-SKHGL------FVEK------D-IQL-----F-CSQIIHHLNDFEFASHRLRYVLLGYFSVIALTGNFDIFIGLILRVHNV------SFCNL-LATAGFIILLSVGIFGLVFGSF------IAQLNTLTIRL-HQLSCR-K------TL--STHSASKVLEIMDRAAGPYNGLKIGDFV-TLEKQFFILFTLENISLLML---FTCNIGPLLN------TuGR164/1-434 ------M------AAKVRSL------LSKQ------KSFFRKI------Y------SFE-I------PDS-KEFDE------TVCNKIRQT--ERLTIFFQ-IV-RNGLNQ---SDSV------EVDTFGFRRFNWMDWL---ISILCLINAIRCGILTQ-N------TNDSVAVYLGNIFFRDAK-GY---VLLLWCLVATIGLG--FFREWLM---TLEAKGKFKV-L------SVWN------VCRNG-FI--PVNLQMNELNTKRF-----RFT-VY------LVTLFVYWTML------ATPLFCIFLYLSL----LL------NNPWA-YQ------IHGLT-L----FSLLWLPVF------ILSLSTLLNTIMGFGWYIMCSLYFHLYRLRDL------IDCA-DF-LLNN-LKHGL------FAEK------D-MQL-----F-CSQIIHHLNDFEFASHRLRYVLLGYFSVIALTGNFDVFIGLILRVHTV------SFCNL-LATAGFIILLSVGIFGLVFGSF------IAQLGTLTIRL-HQLSCR-N------TL--STQSASKVLEIMDRAAGPYNGLKIGDFV-TLEKQFFILFTLENISLLML---FTCNIGPLLN------TuGR115/1-424 ------M------KVLLL------LK------QIIYN------IVG-Y------PK--DEPLQ------STIEALSVF--EKRTKWFR-CL-HYGFVQ---SKQT------KSRS----NFDYISWA---IRLTAVINIIRGLTLAS-T------NNSWYHLILGDPLFGTNV-LP---YASLFISIWLAYIY--SLFEWFR---WAERSGSLFM-L------YDFH------QCRLDN-FN--SLQDELTASSFATF-----RTL-TH------IISVFFSRFLV------WGVFMITLLINGP----LL------SNPLY-YH------NYEFT-I----TSSLWSISL------TFPMVYLFNCSASIGCYFILISLLMLIRYKSL------VKKG-YI-AKVT-AS------NLNR------D-VSY-----L-VNRTISLGNETDALSRSLKYLILYYIILASIVCDLGIFFGIIVPNESI------LIRYI-LCSMGFLVIALLGAALYFNGDP------IQDLSKLHRYF-LQILLK-R------RFTNFNNELFKIYEIFDRIIGPYNGVSAGDFS-VITKRFFLTVLMENASMLML---FTCNVQTYMQR------K------TuGR116/1-439 ------MNA-----ME------LTCFKFN------SSSK------KALLL------LK------QIIYN------IVG-Y------PK--DEPLQ------STIEALSVF--EKRTKWFR-CL-HDGFVQ---SKKA------KSTV----KFDYISWA---IRLTAVISIIRGLALAS-T------NNSWYLLILGDPLFGTNV-LP---YASLFITIWLINIY--IIFEWFR---WAERSGSLFM-L------YDFH------QCRLDN-FN--SLQNELTASSFATF-----RTL-TH------IISIFFSRFLV------WGVFMITLLINGP----LL------SNPFY-YH------NYVFT-I----TSSLWSISL------TFPMVYLFNCISCIGGYFILISLLMLVRYKSL------VKKG-SI-VKVT-AS------NANV------D-ISY-----L-VSRTISLGNETDALSRSLKYLILHYIMFISMVGDLGIFFGIIAPTESI------LIRYI-LSSLGFLILGMLGAALYFDGDP------IQDSIKLYRYF-LQILLK-R------RFTNYNNELFKIYEIFDRIIGPYNGVSAGDFS-VITRQFFLTVLMENASMLML---FTCNVQTYMQR------K------TuGR122/1-440 ------M------AN------YPSSSPI------ESSK------GNNNDST------IR------KLLFY------LLG-L------PRP-GDLEG------STIECINQY--EKTSSVFH-VI-RYGIKQ---KQGEYRF----ASST----HFKIRSFF---IHTFSMIGFFRLLTLML-V------TDESVHIYLGDGLYSSKQ-AS---IIYFLCIITLGSLY--GFGEITL---YQESSGYWKP-M------RVLD------QLRSPN-LN--PSSIGLTRSYLTKA-----CSL-IH------LVAKHGVRIMN------CAPLYMIFIIEAP----IV------AELSL-KE------NPMFN-F----YCLLWSFFL------ACPFIYHMAGNFGRAGYLIMYGICSILRLRSL------ETLV-KH-SSCQ-LT------LIER------D-INS-----L-VSAIISFCNEMEQVFRSIRFGIFYAVFVIAFMADVQLFFGVIIPLEPA------LVAHL-LAVNAAVILFALGLTVYFCGVY------LNTLQSTVVQF-HRICTA-Q------NI--SVLTKLKINELMDRMAGPYNGIEAGWFG-TLTTKFFVIFLVENASTMML---FAVNVVGYLIK------TuGR125/1-429 ------M------KQNF------IK------LFYFD------LL------KVIKL------IVT------KQFHE-HDFKQ------VSIESIELL--EHRIKFYL-AL-RHGFDQ---NIDKTT-----KLDQ----KKDFGHWM---LRFWYLVGMLRAVVVLN------IHDETAIYFGDLAYGSKD-RD---FLWIIIIVGVTIMA--MCHELVL---IVENRDGFVGEP------ARIK------VLLKNG-FS----HFPFVKLQQNEF-----CRL-IY------FIGEFHNFFIV------TIVPHILILYNYE----LV------ICVYK-NL------SLKTI-F----FEIAWTCTL------TPLVTYYAVQLVCYGALFCIYAGVFYYHMDSL------VNAT-ST-LLASIDN------ARNT------D-IKF-----I-LEHTLILFNEIDFYSSRVRSMLFYFYTGVALQSLWFIQFGVIVGNHSV------VMDIL-IAFIGIALIAHNLITSLFSAQL------NKKVASLYSMW-HQIYCK-S------RS--TTIMKLKMVEILNRLTLPTTGVQIGDFG-LVTKEFVLIFFLEFISTIMM---FKVNFGSFFS------TuGR126/1-429 ------M------KQNF------IK------LIFFD------LI------KLLKL------IFT------KQFHE-HDFKQ------VSIESIEML--EHRFKFYL-AL-RHGFDQ---NIDKTT-----KMNQ----KKDFGHWM---LRFWYLVGMLRALVVLN------IHDETAIYFGDLAYGSKD-RD---FLWIIIIVGVTIMA--MCHELVL---IVENRDGFVGEP------ARIK------VLLKNG-FS----HFPFVKPQQKDF-----CRF-FY------FIGEFHNFAII------MVVPYIWILYNYE----LV------ICVYK-NL------SLKTI-F----FEITWTLTL------TPLVSYYAVHLLCYGALFCIYAGVFYYHMDSL------VNAT-SA-LLASIDK------THNT------D-IKF-----V-IEHTLILFNEIDFYSSRVRSLLFYFYTGVAFQSLWFIHFGVIVGNHSV------VMDIL-IATLGIVIVVYNLIISLFSAQL------NNKVASLYPMW-HQIYCK-S------RA--TTIMKFKMVEILNRLTLPTTGVQIGDFG-LVTKEFVLIFFLEFISTIMM---FKVNFGSFFS------TuGR127/1-435 ------M------KQKF------VKSR------PAIFFLK------LI------KFIHQ------IVV------HRFYG-YDFKQ------LSIESTEAL--EHRFKFYF-AL-TNGFDQ---NIDKII-----EMEQ----KINFGTWL---IRFGYLVSMLRAIAIIN------IHDETAIYFGDSAYGSND-RD---YLWIVIIVGVTVMV--MCHEIVL---IVEKKGGFVGEP------SRIK------VLLKNG-FS----HFPFVKPRQKDF-----CRF-FY------LLSAFHNIALT------MLVPYIVILYNYE----LC------ICIYN-YF------SLKTI-I----CEIVWTLTL------TPLVIYLAVQELCYGSLFYIYVGVFYFHMNSL------KNAT-SW-LLESIDK------PQNT------D-IKF-----I-AKNALLLFNKMDSYSSKVRSLVLYFYTGVAFQSLWFIHFSIIVGNHSV------VMDIL-IALLGIFIILYNLIISLFSAQL------NNKVRSLYSMW-HKIYCK-S------KS--NAIMKLKMIEILNRITLSSTGVQIGDFG-LITNQFVLVFFLEFVSTIMM---FKVNFGSFFAKQ------TuGR544/1-432 ------M------KQNF------AKSR------VVLLLSD------LW------KFVQL------IFR------QQLND-HDFEQ------LALGATETL--EHQTVFYF-AL-RLGFDQ---SVEKLE-----EMKR----QFDLKNWV---VRFFILINLSRAFFVFS------AEGDTAIYLGDPLFASKD-RD---VLKIVVVVGTAVMY--FAHEGIM---LVERQGGFVGAA------IRIK------DLLKKG-FS----HFPFVEPQQKDF-----NRT-CY------YISLFWNFICP------MTVLYVTILYNYE----LV------INLYN-HF------SLKTL-F----FEVAWTLTL------TPLVALLATQLICVAAILCLYATVHHFHMESL------INAT-SL-LLKSLDK------PYNS------D-IRF-----I-TRHATVLFNELDLNFRKVRFMVFYFYTGVALQSLWFIQFAIIIGNHSI------VMDGL-IACLGINIIGYTLVISLVCARL------TNKVGRLYPMW-HQVYLK-S------EA--KINMKLKIIEILNRTTLPTTGFQIGDFG-VITTDFVLIFLLEFISMMMM---LSCNFGSFF------TuGR130/1-432 ------M------KQNF------AKSR------VVLLLSD------LW------KFVQL------IFR------QQLND-HDFEQ------LALGATETL--EHQTVFYF-AL-RLGFDQ---SVEKLE-----EMKR----QFDLKNWV---VRFFILINLSRAFFVFS------AEGDTAIYLGDPLFASKD-RD---VLKIVVVVGTAVMY--FAHEGIM---LVERQGGFVGAA------IRIK------DLLKNG-FS----HFPFVEPQQKDF-----NRT-CY------YISLFWNFVCP------MTVFYVIILYNYE----LV------INLYN-HF------SFKTL-F----FEVAWTLTL------TPVVALLATQLICVAAILCLYATVHHFHMESL------INAT-SL-LLKSNDK------PYNS------D-IRF-----I-TRHATVLFNELDLNFRKVRFMVFYFYTGVALQSLWFIQFAIIIGNHSI------VMDGL-IACLGINIIGYTLVISLVCARL------TNKVGRLYPMW-HQVYLK-S------KA--TINMKLKMIEILNRTTLSTTGFQIGDFG-VITTDFVLIFLLEFASMMMM---LRCNFGSFF------TuGR546/1-432 ------M------KQKL------AKHR------LALLLSD------LW------KFVQL------IFR------QQLNE-HDFEQ------LAIGAVETL--EHQIVFYF-AL-RLGFDQ---SVERLV-----EMKR----QFDLKNWL---VRFFILINLSRAFFVFS------AEGDTAIYLGDPLFASKD-RD---VLKIVVVVGTGIMY--FTHEGVM---LVERQGGFVGAA------IRVK------DLLKNG-FS----HFPFVQPQQKDF-----NRT-CY------YISLFYIFSIP------VTILYVSILYNYE----LV------INLYN-HF------SFKTL-F----FEIAWTLTL------TPLVTLLTTQLVFISAVLCFYATVHNFHMESL------INAT-SL-LLKSLDK------PYNT------D-IKF-----I-TKHATVLFNAMDLNFRKVRFLVFYFYTGVALQSLWFIQFAIIIGNHSF------VMDTL-IAGLGIIIISYTLIISLVCARL------TNKVGRLYPMW-HQVYLK-S------KA--TINMKLKMIEILNRTTLPTTGFQIGDFG-VITTDFVLIFLLEFASMMMM---LRCNFGSFF------TuGR132/1-432 ------M------KQKL------AKPR------LALLLSD------LW------KFVQL------IFR------QQLHV-HDFEQ------LALRATETV--EHQIVFYF-AL-RLGFDQ---SVEKLE-----EMKR----QFDLKNWL---VRFFILINLSRAFFVFS------AEGDTAIYLGDPLFASKD-RD---VLKIVVVVGTAVMY--IAHEGVM---LVERQGGFVGAA------IRIK------DLIKNG-FS----HFPFVAPQQKDF-----NRT-CY------YISLFYIFSIP------ATILYVSILYNYE----LV------INLYN-HF------SFKTL-F----FEVAWTLTL------TPLVTLLTTQLVFISAVLCFYATVHNFHMESL------KNAT-SL-LIKSLNK------PYNT------D-IKF-----I-TKHATVLFNEMDLNFRKVRFLVFYFYTGVALQSLWFIQFAIIIGNHSF------VMDTL-IAGLGIIIITYTLIISLVCARL------TNKVGRLYPMW-HQVYLK-S------KA--TVNMKLKMIEILNRTTLPTTGFQIGDFG-LITTQFVLIFLLEFASMMMM---LRCNFGSFF------TuGR131/1-432 ------M------KQKL------AGSR------LVLLFSD------LW------KFAQL------IFR------QQLND-HDFEQ------LALSATETM--EHQIVFYF-AL-RLGFDQ---SVEKLV-----EMKR----QFDLKNWF---LRFFILINLSRAYPVFS------AEGDTAIYLGDPLFASKD-KV---VLKIVVVVGTAVMY--FAHEGIM---LVERQGGFVGEA------MRIK------DLIKNG-FS----HFPFVAPQQKDF-----NRT-CY------YVCLFWNFSCP------LIILYVTILYNYE----LV------INLYN-HF------SFKTL-F----FEVAWTLTL------TPLVALLAAQLVCLGAVSCLYTTVHHYHMGSL------KNAT-SL-LLKSNDK------PYNS------D-IRF-----I-TRHATVLFNEMDLNFRKIRFLIFYFYTGVALQSLWFIQFAIIIGNHSV------VMDTL-IAGLGIIIITHTLIISLVCARL------TNKVRRLYPMW-HQVYLK-S------KA--TIIMKLKMIEILNRTTLPTTGFQIGDFG-AITTDFVLIFLLEFASMMMM---LSCNFGSFF------TuGR128/1-435 ------M------QKMVQNI------LNAL------YPSFISD------LI------KVAQL------IFI------NKSYN-YDFEQ------LALESATKL--EEQMSFYS-VS-RYGLDQ---TFDKIA-----VINR----QFDVGNWL---IRVVTLVNLARMIILLK------VDDETAIYLGDPLLNSKD-KY---SLLIVVIVGITAMY--VTHECAV---FIERGGGFVGAA------TNVT------YLLKNG-FS----YYPFSQHQKKNF-----CCF-VY------LICVFHNSLIF------VMYPYIMVLYNHE----LC------WNQYN-HF------SLKTM-L----IAVAWTITL------TSIVICLGAQMVYHSALCCIIAGIFHFHIKSL------TDST-TL-LIKCMDK------MQIV------E-VKC-----V-IRQTLQLFNEIDSSFRKIRFIVLYFYTGVALQSIWFLHFGIFTGNHSI------VLDTL-IAGLGITVITDISAISLFCAAL------TNKVESLYPKW-HRIYSK-R------KI--PIFMKLQIIEILNRITLPTNGIQIGDYG-LITKQFVLKFLLEFASMLML---FKCNFGSLF------TuGR129/1-431 ------M------LKF------FNSP------LTAFAYD------FI------KAVQL------NFD------KRLHN-YDCEQ------LAFKSLETQ--EKQVVFTL-TL-RHGFEQ---SVDKII-----KMRQ----KIDFGNLL---LRIASLVNLVRIILLFS------VSYETAIYLGDPLLDSKD-RN---VLLLVVLVGLTPMY--IVHELAV---IKENNYGFVSAA------SDLK------VVIKNG-FS----YFPFVGLEKKPF-----CRF-IY------LICAFHNMITP------MMIPFITFLYNFE----LF------CNLYN-NY------SLKTM-L----FAIPWSFTL------TTAVIFLAAQAICYSSICCIYVGLHYFHIKSI------TNAT-GF-LLQVNDK------RNCT------D-LNC-----I-IGQTLWLFNKIDSTFREIRFIVLFFYNGIALMSCWFLHFGLFTGNHSV------VMDFL-ITWLGFMIISDILAISFFCAAF------TNKVDRLYPMW-HRMYCK-S------KT--TTAMKLKMIEIFNRIILPTNGIQIGDYG-LITKKFVLIFLLEFSTSLML---LRVNFGSYF------TuGR170/1-452 ------M------ESH------EKLK------YFSAFREK------LH------RAITI------VLG-L------PYH-KSLHH------DYCQAINRF--EQLTMILG-SC-KYGFNS---GNKLYRL----KVDT----QFHYMHCI---IRISLFALAIRLILCLF-S------TNRMVHVFLADPFIDYKP-SW---PIYCFLLFTVISLS--LLKEAYL---RIESQGVLNQHL------DVYN------EIRRNR-MS--IVKL-ISENRVKIF-----YSV-TI------FCANFWHRLIL------LTIPTACFFSFVI----YH------ESTEL-YR------DSQYL-W----STLFWFPST------LLSIISLVTFLMSIGGYQFITVNLILFRLRSI------VVQI-QT-VRAS-GAPTAG------ITWEG------FND---DTFVYKQIIAYLNKLDYLSKGYKSLIFGIILLPASISNFSVFAGIVVRSQSE------LLSSF-LLAFGLSTFIGLTLVIYFCADI------MNQLRKIHDQL-HLLNRG-I------KL--RVSSHFKINEIIARLQGPTNGIKIGDLA-TMTERFAVIFMAEFATSLLL---QVCNFRPFTIEIYK--HGFIPKC------TuGR167/1-433 ------M------YGFLT------KCKAAFHELICK------ILI-LAG-----HSK-GEPFT------EAGKSLRRF--ESLTISSR-AS-NYGFKYCNQKNRT------HVNS----KVDKIHLL---IRLSVFSSIVRVFTFIF-F------PNGNISLYLANIRYKSDK-SD--AAIFTVVLFASISCL--LIREYFL---IIERRNVFRYNF------TIYH------CLINNH-LK--QCKLKLFPTLVEPF-----YRT-VT------SISILAYQLTL------SATISCFTCNVLI----YF------FNDNF-YS------DNVYR-I----FCLLWIPAA------SITFASLANSVNSVAGYLALHITFDLYRVQSM------KLWV-KY-LRNE-HT------KDTR------V-QSK-----I-MSLIISCLNEYDYQSKRVRKLAFIGMFMFFMMTNLLLFISGIVKSYSQ------AFQIF-LIFLGSSSIIVVVCLCYATATF------LSQLNNLYHQL-HLSCRY-N------KF--NLSVSLKALEILDRVLSPHNGTTIDGGL-QVTKTFVVFFCLEFASVFML---LVCNLKQKLF------TuGR169/1-430 ------M------CKYLT------RLKAAFHQLMSK------ILL-FTG-----YSK-SEPFT------EASKSLKQF--ESLTISLK-AS-KYGFKYCNQKNRT------HVHS----KVDPIYLL---IRLSILSSIGRVFMFIF-F------PNETISLYLANIHYHSEK-PL--TVIFMIVLFAIISCL--LIREYFL---VIERRNVFRYNF------TIYH------CLINNN-LK--QCHLKLFPTLIEPF-----YKT-VT------LISILAYHLTL------VATFSGYVCVVLI----YL------NNSNF-FT------DNVYR-I----CCLLWVPAS------SITFAGLASSVNSVAGYLALHITFDLYRAQSM------KLWV-KH-LRNS------HNKR------V-QSK-----I-LSLIISCLNEYDYQTKRARNLGFIGITMFSMTTNLFLFISIIVKSYSP------AFRML-MILLGSASICVIVCLSYAAATF------LSQLNNLYHQL-HMTCRY-N------KF--NLSVSLKALEILDRVLSPHNGIAIDGGL-KISKTFVLSFCLEFASVFML---LICNLKAFF------TuGR168/1-430 ------M------YQILT------QFIATFHQLMSK------ILL-FTG-----YSK-GEAFL------EVGKSLKQF--ESLTISLR-AS-KYGFKYCNQKYRT------HVPS----KVHPIYLL---IRLSVFSSIVRVFMFIF-F------PNETISLYLANIHYKSEK-SH--TAIFTVVLFAIISCL--IMREYFL---IIERRNAIRYNF------TIYL------CLINNH-LR--QCKLKLFPSLVEPF-----YRT-VT------SISILAYQLTL------STTISCLLFSFAM----YF------FNSNF-YS------DNVYP-I----CCLLWMPAS------SITFASLASSVNSVAGYSALYITLDLYRVQSM------KLWV-KH-LRHS------RNQF------D-ASN-----L-LTFIISCLNEYDYQAKRTRNMAFLGITIFAMTANFFLFVSIIIKPYSQ------AFRMF-FIFLGASSIFVTICLCYAAATF------LSQLNNLYHQL-HMSCRY-N------KF--NLSVSLKALEILDRVLSPYNGITIDGGS-KISKLFVVFFCLEFASVFML---LICNLKSLF------TuGR112/1-422 ------M------LH--P-STGAIE---NRMPCK------ICQSME------SNL-YSDET------LVINCMRHL--KKLFDWLL-IL-KKGYHQ---DAPTVP------KKTIYRLAA--ARSLTYLVTFRMIFCLS-I------DDVHLKYLLGYPYKENAE-GV---LLSILMSLTYILFS--LLRELVY---YFESNGKMAV-T------VELN------YLLALTPGQLHSL-----SRLKVFIRY-MKYFLPNWIALFY------FFLCMTPIFSIQI----RL------INPDI-WT------NHVYI-I----SSIIWMIPE------ALTIVYVVGGLIIFFGHALMFLMIYYSRLCYL------LHQF-GR-LVEM-ECSTT------QANE------L-LIK-----L-NYSFIKFLNDITKQAYDVRYVWLYMLLLACGLNNTCLYCGTIKQIKPI------ILAFS-LTIYGVCEFVISAIAIHKAGEI------IEKIYAIHNHY-IKLSLK-L------KT--RLDTRLKVLEILQRIMSPRTCPTIGDFF-EIKKSVVMTFIMENICLILL---ITVNANR------TuGR178/1-435 ------MNQ------IVFQLATSEV------EEEKKSA------LK------KLFFA------IIG-W------PSL-NIEHS------EAARAIKVF--IFYGQLLL-VY-QNGHDI------SS-----KPTK----WFTISTIS---VDFFIYLTLIRLIVNYF-I------NDSIILVCLGDVLSGWDN-GY---PIGILSIIGITCLG--TFRSFSC---YQARNGSLAW-F------RVIE------EASIHG-FT--SKILNMKTVHLMKF-----RQQ-IV------FLSRQIIGASI------VPTTIWIACYVYL----LY------SSPLT-YL------SIQSPLYF-I----CFVSWQLIS------IIAIIFIVPQVAWFAIMIIMSICYLNKRIHSV------YDEL-SS-LSN------INFV------Q-FYR-----L-HHKQVSVLNEIDYINNLLRYIFLVGYYAIGLSGEVTLLYSYLNLFDMP------IADRG-LWIVGSNTIFQIGLASYLAGKI-----L---VKHSYSYY-QKLNQK-NF-----KL--PFRVKLKFLELLNRLDSPNNGFWIGDVF-IMDNLSFVQYCLETCSNMML---FICNLPALVKANS------TuGR175/1-445 ------M------LTVAVLKIRL-SKKKVIKEPKRNK------IF------DLFYR------IIG-W------PQI-DVEHS------KAVEAIKRF--MFFGKILL-VY-QPHPNA---VHPI------APTR----WFTYLSLT---IDLCTLITVIRLIFCFF-T------DNLLTLAYMGDIFVGIRN-AY---ALRMLSVCAIACLG--AFRAISC---YLARNGSLDW-T------KVID------KAMING-WK--PEVLNMKELYCLKW-----RQI-SV------FITRQVVGASL------VIASVWLTCYVYL----TV------NCKTV-YM------ALQNPTIL-----GFFAFWQVIA------LIAMIWLVPQAAWIGVLYVIVTSYVLNKSNSV------YSDL-QT-SLKW-RY------IPSL------V-LRK-----L-CNQNILFLNEFDSINRFTRYISYAAYNLISVVGQVAIFYSYLGLFGMP------LADRG-LGLIGFNTIFQIGFSSYLAAKS------VAKIGLSYSHY-HRIYQN-NI-----NI--EPRLKLKLLGNLDRLSSPFVGFWVGESF-AMDNYSFIQYVFETGSNMML---IIVTMSNLIWKN------TuGR171/1-463 ------M------SSGTILKI------EKLKER------IF------GLIHA------IIG-W------PQI-DIEHA------KAVEAIKRF--MFFGKLLL-VY-QPHPNA---DHPV------PPTK----WFSYLSVT---IDLCTLTTVIRLICCFL-T------NNLLTLAYMGDIFIGMRN-AY---ALRLLAVCGIICLG--GFRAVSC---YLIRNGSLDW-T------KVID------KAMING-WK--PEVLNMKELYCLKW-----RQT-SV------FIARQIVGTSL------IVASIWITCFLYL----MF------SSTAF-YLALQNAFIAAVWITCWVCLTINCATFNLTLQSPLVA-----SLFTLWQAIA------LISVIWFVPQVAWIAFLYGIAFFYVINKSNSV------YSDL-RA-ALKL-KR------MRSL------A-LKK-----L-YNQNILFLNEFDYINRLMRYIGYSGYTLVSLAGQVAMLYSYLGLFGMP------LADLG-LGIIGCNTIFQIGLSSFLAAKS------VSKIGLSYSHY-HRIYQN-NI-----NI--ETRLKLNFLYNLDRLSSPFVGFWVGDSF-MNDNFAFIQYLFETCSNMML---IIVTMSNFIWQN------TuGR172/1-436 ------M------SIGTILTI------KKLKER------IF------GLFHA------IIG-W------PQI-DIEHA------KALEAIKRF--MFFGKLLL-VY-QPHPYA---DHPI------PPTK----WFTYMSVT---IDLCTLTSVIRLICCFA-T------DNLRTLAYMGDIFIGMRN-AY---ALRLLAVCGITCLG--GFRAVSC---YLIRNGSLDW-T------KVID------KAMTNG-WK--PEVLNMKKAYCLKW-----RQT-SV------FIARQIVGTSL------IVASIWITCFLYL----MF------SSTAF-YL------AIQNAFIL-----SFFAFWQVIT------LIAIIWFVPQVIWISLLYVIIFFYAINKSNSI------YSDI-QA-ALKL-KR------MRSL------A-LKK-----L-CNQSILFLNEFDYINRLMRYISYFGYNLVSVAGQVAMLYSYLGLFGMR------LADLG-LGIIGFNTIFQIGLSSFLAAKS------VSKIGLSYSHY-HRIYQN-NY-----NI--EPRLKLKLLYNLDRLGSPFVGFWVGESF-SNDNRAFIEYLFETCCNMML---ISVTMSNFIWKN------TuGR174/1-437 ------M------TSDTQPKI------KQPKKNV------IS------GLFYA------IVG-W------PHI-DIEHA------KAVEAIKRF--MFFGKLLL-VY-QPHPNA---DHPI------MLSK----RFLLLSFT---IDLFTLLTVIRLICCFF-T------DNLLTLAYLGDIFVGKRN-EY---ALRMLSVCCVACLG--GFRAVSC---YLARKGSLDW-T------KVID------KAMING-WK--PEILNMKKAYCLKW-----RQT-SV------FIARQIVGASL------IVASIWVTCFLYL----MF------SSTAF-YL------ALKSPLVI-----SLYTFWQVIA------LSAIIWFVPQATWIGFLYGIAFFYVINKSNSI------YSEL-QT-SLKL-KY------IRSS------A-LRK-----L-CNLNISFLNEFDHINCMMRYIAYAAYNLISVTGQVAMLYSYLGLFGMP------LADLS-LGIIGCNTIFQVGLSSFLAAKS------VAKIGLSYSHY-HRIYQN-NY-----NI--EPRIKLKLLYNLDRLNDPSVGFWVGESF-INDNYAFIQYLFETCSNMML---IIVTMSSFIWQD------TuGR173/1-455 MEFS------TFI------ISSVHFNRSEVA----M------SIGTIVKF------EKLKKQ------TF------QLFYA------IIG-W------PRI-DIENA------NAVKAIERF--MFFGKLSL-IY-QHHPNA---VHPI------TPTK----WFTYLSVT---IDFCTFITVIRFICGFF-T------DNLLILAYLGDVFVGLRH-AY---ALRMLALFCIACLG--GFRAITC---YLVRNGSLDW-T------KVID------KAMIDG-WK--PEVLNMKKGYCLKW-----RQT-SV------CIARKIVVPPL------VHASVWITCFTYL----TL------NCKTF-YV------VLKSQLIL-----GLFVFWQVTT------LISIIWFVFHVVWISLLYFITFFYVINKSNSI------YSEI-QE-SSKF-KL------LSYS------A-LNK-----L-CNKNISFLNEFDNINHLMRYISYSGYILASLAGQVAMLYSYLGLFGMP------LADLG-LGIIGFNGVFQMGVVSFLAAKS------VANIGLSYSRY-HRIYQN-NY-----NI--EPRLKLKLLYNLDRLGSPFVGFWVGESF-SNDNRAFIQYLFETCCNMML---ISVTMSNFTWKN------TuGR176/1-436 ------M------GIITAIKV------VVSNK------IS------KIFYG------IIG-W------PEI-DIQND------KAVEAVGRF--MFIGKLLL-VH-QPHPDE---DRTV------PPTK----GLTYLSIT---IDLFVLTIIIELLCAFC-T------DNRITLAYLGDVFVGMNN-EY---ALRMLCLCGTFCLG--ATRAVSC---YLARNGSLDW-T------KVIY------KAMING-WK--PEVLNMKRAYCLKW-----RQT-CV------FIARQIVGTSI------ILTSVWVTCFAYS----TY------NCKTL-YL------ALERPLIL-----TCFMFRQIIT------FFAIIFVVPQVAWFCFLLVISITYLIYRSNSV------YVDL-QK-SLQF-ES------LPVS------V-ITK-----I-CTKNISLLNEFEFINRQMSYVSYCGYNLISFAGQVALLYSYLGLFGMP------LADLG-LGIIGFNTVFQVGIVSFIAAKS------VANVGFSYSHY-HRIYQN-NY-----NI--EPRLKLKLLYNLDRLSSPSVGIWVGESF-LMDKYSFIQYLLEMCSNMML---IIVTMPALIWRDT------TuGR177/1-436 ------M------GRLTAINI------KKSKI------IS------KLFYA------IIG-W------PQI-DIAHD------EAVEAIERF--MFIGKLLL-IH-QPHPDE---DRPV------PPTK----GFTYLSIT---IDLFILTIIIELLCAIC-T------DDLITLAYLGDIFVGMNN-EY---ALRMLCLCGAFCLG--AFRAVSC---YLARNGSLDW-A------KVID------RAMIYG-WK--PEVLNMKQEDCLKW-----RQI-SV------FMSRQIVGTSV------VSALVWLTCLTYS----TY------NCETF-YL------ALKRPLIL-----TCFLFRQIIT------LFSIIVVVPQVAWFSFLFIISVAYLIYRSNSV------YIDL-QK-SLQF-ES------LPVS------V-ITK-----L-CTKNISLLNEFEFINRGMSYVSYCGYTFVSVAGQVAMLYSYLGLFGMP------LADLG-LGIIGFNTVFQIGVISFLAAKS------VSKIGLSYSHY-HRIYQN-NY-----NI--EPRLKLKLLYNLDRLSSPYVGFWIGESF-LMDNYSFITYLLETCSNMML---IIVTMPALIWKDQ------TuGR186/1-440 ------MKPLSKLTA---M------LRVNKI------LITC------IP------GLIR----SLIDR------LIR-F------RSS-DVNDA------EAISKIKKL--ESICMSFN-IL-PNGLSQ---DPKV------TPTK----WTTVKSIL---YYTLMTVHIIHLALLSVFD------LPNEWLLVLGDFFYGQKN-RR---YFWCIWLNASIVGE--ICRYYWI---FLIKNGHFRT-F------KLYS------LIYERG-FK--SEVLSMNESHCRKF-----RFV-AS------NLANAWFWLVY------CIAITFAPILIFI----VH------SANQL-PQ------TSIQF-I----YNSFWILVN------YLGIVSTCCNMALTAALVTVHFSYFYFKAAHV------TGTA-EG-LATK-RGH------MNKA----DYMLH-YKA-----T-VSEIIQYQNETEQINVNIRNWLIFPYIGLSAAADFGVYIAIFVHIDP------FMDFF-VVIVASIGVVIIGACSYINGVI------LTMMSSYCKNL-RKATRY-L------QL--SERAFIKGTDLQDRLSRTDIAFTIGELL-NMTPRVFVIYLIENICLIMM---FKVNFK------TuGR183/1-449 ------MKTKKSLQV------IKSKIKPLMKLSA---I------LKVNKI------LTAY------LP------RLIIR------VIG-F------RSS-DVNDA------EAISKIKKL--ESICISFN-IL-PNGFSQ---DPRV------TPSR----WTTTKSIL---YFSLMTVHIIHLALLSVFD------LPDEWLLVLGDFFYGQKN-GR---YFWFIWLNISIVGE--ILRHYWI---FLFKNGHFET-Y------KLYS------LIYEKG-FK--SQLLSMNQCYCQKF-----RFV-AI------NLANAWLWIVY------CIAITFAPILIFV----VN------SSNQL-PQ------TSIQF-I----YNSFWILVN------YLGIVSTLYNTILPGALVTVHLSYFYFKAAHV------TQTA-EG-LATE-RKL------LNKV----DYLHH-YKA-----T-VSEIIQYQNEIEQLNVNIRNWLIFLYIGLSAAADFGMFIAIFVHIDR------FMDLF-VVIVTSLGVVAIGACSYTNGVI------LTMMSSYCKNL-RKATRY-L------QL--SARAFIKGTDLQDRLSRTDIAFTIGELL-DMTPRVFVIYLIENICLIMM---FKINFK------TuGR185/1-427 ------M------LRFNED------LIAS------LP------RLIVR------VIG-F------RSS-DVNDA------EAISKIKKL--ESICISFN-IL-PNGFSQ---DPRV------TPSK----WTTVKSIL---YLSLMSVYIIHLALLSVFD------LPNEWLLVLGDFFYGKQN-RR---YFWFMWLNASIVGE--ILRHYWI---FLTKNGHFET-Y------KLYS------LIYEKG-FK--SQLLSMNESHCQKF-----RFV-AI------NLANAWLWIVY------CIAITFAPILIFV----VN------SSNQL-PQ------TSIQF-I----YNSIWILVN------YLGIVSTLYNTILPGALVTIHLSYFYFKAAHV------TQTA-ED-LATK-RKL------LNKV----DYLHH-YKA-----T-VSEIIQYQNEVEQLNVNIRNWLIFLYIGLSAAADFGMYIAIFVHIDK------FMDLF-IVAVASIGVAAIGACSYTNGVI------LTMMSSYCKNL-RKATRC-L------QL--SARAFIKGTDLQDRLSRTDIAFTIGELL-DMTPRAFVIYLIENICLIMM---FKVNFK------TuGR184/1-450 ------MKTKKSIQV------LESKLKLLSKLSN---M------LRVNKI------LTAS------LP------RLIFR------VIG-F------RSS-DVDDS------EAISKIKKL--ESICISFN-IL-PNGFSQ---DPKV------TPSK----WTTVKSIL---YFSLMSVYIFHLALLSVFD------LPDEWLLVLGDFFYGKQN-RR---YFWFLWLNASIVGE--ILRHYWI---YLVENGHFKT-L------KLYY------SIYENG-IK--SEVLSMNHCYCQKF-----RFV-AI------NLVNAWLWIVY------CIAITFAPILIFI----VH------SADHK-PQ------TSIQF-I----YTGFWIFVN------YLGIVSTLYNTILPGAIVTVHLSYFYFKAAHI------ARTA-ES-LAAE-RGL------LNKV----DYLLH-YKA-----T-VSEIIQYQNEIEQLNIKLRNWLIFLYIGLSAAADFGMYIAIFVHIDK------FMDLF-IVAVASIGVAAIGACSYTNGVI------LTMMSSYCKNLIRKATRC-L------QL--SARAFIKGTDLQDRLSRTDIAFTIGELL-NMTSRVFVIYLIENICLIMM---FKVNFK------TuGR187/1-436 ------MMPLVKPTA---M------IRVNKL------LTAS------FP------RFIVR------FIG-F------HSS-DVDDA------EAISKMKKL--ESVCISFN-IL-PNGFSQ---DQNV------TPSK----WTTTKSIF---YSSIMTVHIIHLALLSIFD------LPDEWLLVLGDFFYGQKN-GR---YFWFAWMYASIVGE--TLRHYWI---YLMKNGHFTT-F------KLYS------LIYEKG-FK--SQLVSFNTFYCQKF-----RFA-VS------NLANAWLWLVY------FIVITFGPILIFF----VN------STNQL-PQ------TSIQF-I----YNSFWILVS------YLGIVFTLCNMALTASVVTFHCSYFYLKAAHV------ARTA-EE-LATE-RRL------LNKR----DYMFH-YKA-----T-VNEIIQYQNEVEQINLKIRNWIIIGYIGLSAAADLGMYIAIFVHIDQ------FMDIF-IMIVATTGVVAVGVCSYINGVI------LTMMSSYCKNL-RKATRY-L------QL--SARASIKGNDLQDRLSRTDIAFTVGEIL-DMTPRVFVIFLIENICLIMM---FKVNLQ------TuGR648/1-436 ------MMPMSKPTA---M------LRVNKL------LTAS------FP------RFIVR------FIG-F------HSS-DVDDA------EAISKIKKL--ESVCISFN-IL-PNGFSQ---DQNV------TPSK----WTTTKSIF---YSSIMTVHIIHLALLSIFD------LPDEWLLVLGDFFYGQKN-GR---YFWFAWMYASIVGE--TLRHYWI---YLMKNGHFTT-F------KLYS------LIYEKG-FK--SQLVSFNTFYCQKF-----RFA-VS------NLANAWLWLVY------FIVITFGPILIFF----VN------STNQL-PQ------TSIQF-I----YNSFWILVS------YLGIVFTLCNMALTASVVTFHCSYFYLKAAHV------ARTA-EE-LATE-RRL------LNKR----DYMFH-YKA-----T-VNEIIQYQNEVEQINLKIRNWIIIGYIGLSAAADLGMYIAIFVHIDQ------FMDIF-IMIVASTGVVAVGVCSYINGVI------LTMMSSYCKNL-RKATKC-L------QL--SARASIKGNDLQDRLSRTDIAFTVGEIL-DMTPRVFVIFLIENICLIMM---FKVNLQ------TuGR188/1-426 ------M------AMSKG------NHF------VS------RLIRL------VIG-F------RSR-DVDDE------VAIKDIKKL--ESICISFN-IL-PNGFSQ---DPSV------TPSR----WTTIRSIL---YFSLMTVYITHLILLSVFD------LPDEWLLVLGDFFYGHPN-RR---FFWLFCLNVSIFGE--VLRHFWI---FLVENGHLTT-L------QLHH------SIYLKG-YK--SQVLCMSQFYCQKF-----RFV-AT------NLAILWVRIVL------CVSISLAPIFIVI----VH------SVSRL-PK------TSEQY-V----YIGFWLLVN------YLGLVCTLVSIMLPGALVTIQLSYFYFKASSV------ARTV-QD-LAVR-RGR------LSKV----DYLLE-YKT-----T-VCEIIQYQNEIEQVNIHFRNWLIFLYLGISFATDFGAYIAVFVHIDRG------FMDLF-IAGISIIGLVSIGACSYTNGVI------LTKMISYCKNL-RKATRC-L------QF--NAKAFIKGTDLQNRLSRTDIAFTIGSLF-DMTSRVFVIYLIENICLIMM---FAVNLR------TuGR189/1-455 MLDE-----PLLNKNLKYHNF------FKFQVYSKFKQVF---M------AMSKG------NHL------IS------KLIRL------VIG-F------RSS-DVEDE------VAIKDLKKL--ESICISFN-IL-PNGFSQ---DPSV------TPSR----WTTIRSIL---YFSLMTVYITHLILLSVFD------LPDEWLLVLGDFFYGHPN-RR---FFWLFCLNTSIFGE--VLRHLWI---FIVKKHYYAS-L------QLQH------SIYSEG-FK--REVLFMSQFYCQKF-----RFV-AT------NLAALWVRIIL------CVSISLAPIFIFI----VH------SVSRL-PK------TSEQY-V----YIGFWLLVN------YLGLVCTLVSIMLPGAVVTIQLSYFYFKASSV------ARTV-QD-LAMK-RGK------LSKV----EYLLE-YKT-----T-LREIIQYQNEIEKLNLRIRNWLIFLYLGISFDTNFGAYIAVFVHIDRG------FMDLF-IAGISIIGLVSIGACSYTNGVI------LTKMISYCKNL-RKATRC-L------QL--NPKAFIKGTDLQSRLSRTDIAFTIGSLF-DMTSRVFVIYLIENICLIMM---FAVNLR------TuGR201/1-426 ------M------LRAKH------IGI------VS------KSVRY------VIG-F------QSS-DINDT------VAIKYLKQL--ESMCISYN-IL-PNGFSQ---DPSV------TPSK----WTKTKSIL---YISVMTINIIHFILLSAFD------LPDEWHLLLGDFFHGHPN-GR---FFWLFCLNLSVFGE--VIRHHWI---FLARRGHLTT-F------KLEH------LIYSKG-FK--SRVLFMDRFYCKKF-----RFV-ST------NLAIFWVRITY------CLTISFAPILIFI----VH------SASKL-PQ------TSQQY-I----YTGFWLLIS------YLGISCTVSNLMLSGGLATVQLSYFYYKVAHV------ARTV-QD-LSMK-RRR------SKNA----DYLLD-YKA-----I-VCEIIKYQNETEHCNIGVRNWFIFVYIGLSAVDNFGVYTAVFVHIDRG------FMDFF-ILGVSMIGFVSIGACSYTNGVI------LTKMISCCKNL-RKATSR-L------KL--NAETFIKETDLEERLSRTDIAFTIGQLL-DMTTRVFVIYLIENICLIMM---FKVNFQ------TuGR202/1-448 ------MHCLQFYYC------ELYKITVKLKGKA---M------LRSKQ------IAI------VS------QLVRH------VIG-F------RSS-DINDT------VAIKYLKQL--ESMCISYN-IL-PNGFSQ---DPSV------TPSK----WTKIKSLL---YISIMTINIIHFILLSAFD------LPDEWHLLLGDFFYGHPN-GR---FFWLFFLNFSVFGE--VIRHYWI---FLAGNGHLTT-F------KLEH------LIYSKG-FS--SRVLFMDPFYCKKF-----RFV-AT------NLAIFWVRTSY------FLTISFAPILIFI----VH------SASKL-PK------TSEQY-I----YTGFWLLIS------YLGVACTMSNLILSGGLATIQLSYFYFKVAHV------ARTL-QD-LSMK-RRH------SKNA----EYSLD-YKP-----I-VCEIIKYQNETEHCNIGVRNWFIFVYLGLSAVDNFGVYTAVFVHIDRG------FMDFF-ILGVSMIGFVSIGACSYVNGVI------LTKMISCCKNL-RKVTSR-L------KL--DAETFIKVTDLEDRLSRTDIAFTIGQLL-DMTTRVFVIYLIENICLIMM---FKVNFQ------TuGR203/1-427 ------M------LRGQHN------KVDL------GS------KLFRL------VIG-F------HSS-D-DDA------VAIKHLKRF--ESICISYN-IL-PNGFSQ---DPRV------TPSK----WTTIKSIL---YLSVMTINIVHLTLLSAFD------LPDKWHLLLGDFFYGHPN-GR---FFWIFCLNLDICGE--YMRQFWI---YLIKNGHLTT-L------KLQH------LVYLKG-FK--SQVLLMDRFYCKKY-----RFV-AA------NLAVFWVRMLF------SVTISFAPILIFI----VH------SASKL-PR------TSEQY-I----YTGFWVVTS------YLGIVCTITNLMLTGGLITIQLSYFYFKVAHV------ARTV-QD-LATK-RRH------LNVA----DYLFD-YKA-----T-VREIIQYQNEVEHVNIGIRNLFMLVYLGHSVVTDFGVYTALFVHIDRG------FMDFF-VACVSMIGFTGIGACSYTNGVL------LTKMSSCCKNL-RKATKR-L------QL--NAKSSIKVTDLEERLSRTDIAFTIGKIL-DATPRVFVIYLIENISLIMM---FKVNFQ------TuGR207/1-448 ------MHCLQFYYC------ELLKTTVKLKRKA---M------LKSKY------IEI------VS------QLVGL------VIG-F------RSS-NIDDA------VAIKHIKRL--ESICISYN-IL-PNGFSQ---DPSV------TPSK----WTKTKSIL---YLCVMTVNIIHLILLSAFD------LPDKWHLLLGDFFYGHPN-GR---FFWLFFLNASILGE--VIRHYWI---FLAKNGHLTT-L------KLQH------LVHTRG-YK--HQVLFMDQFYCKKF-----RFV-ST------YLAIFWVRIYF------CVLISFAPVLIFI----FH------SASKL-PQ------ILQQY-I----YTGFWLVIS------YLGIVCTLSNLLLTGSVAAVHLSYFYFKTAHV------ARTV-RD-LSTK-RSY------TNND----DYLLD-YKA-----T-VCEIIQYQNEIEQANIHFRNCLVFFYFGNSFVVNFGVYTAAFVHIDHG------FMDFF-IAGFSIIGFAGIGACSYTNGAI------LTKMNSCCKNL-RKITSG-L------QL--NVQAFIKGTDLEDRLSRTDIAFTIGKIL-DATPRVFVIYLIENICLIMM---FKVNFQ------TuGR209/1-450 ------MLFMHWFEYLYC------ALSKITMRFKRNA---M------LRPKQ------IQN------VS------KLFRL------VIV-F------HSK-H-DDA------LAIKDLKRL--ESICISYN-IL-PNGFSQ---DQRV------TPSK----WTTAKSIV---YISVMTVHIAHLILLSAFE------LPDEWHFLLGDFFYGHPN-SR---FFWIFCLNASIFGE--VLRHFWI---FLMKNGHLTT-L------KLQH------LAYSKG-FK--SQVLLMDQYFCQKF-----SFF-AT------NIAIFWVRILF------LASISFAPILIFI----FN------SVSAL-PK------TGQQF-I----YTGFWLVIS------YLGIVFTISNLMLTGCVAAIHLSYFYFKTAHV------ARTV-RD-LATK-RSY------TNND----DYLLN-YKA-----T-VCEIIQYQKETEQANIHFRNCLIFFYFGNSFAANFGVYIGVFVHIDHG------FMDFF-IAGVSMIGLIGIGACSYTNGAI------LTKMSSCCKNL-RKVTRY-L------QL--NEEDFIKGTDLEDRLSRTDISFTIGKVL-DMTTRIFVIYLIENICLIMM---FKVNFQ------TuGR204/1-453 ------MFFVRFLRFLSF------EFCKIAVRLQKKV---I------PRAKHN------HTEI------VL------KLVRF------VIG-V------HWS-DVDDA------IAVKYLKQL--ESICTTYN-IL-PIQFSR---DPKA------TQSK----LTITKSIL---YSSLMAVNIIHLILLSSFD------LPVEWHHLLGDFFHGHPN-GR---FFWLFFLNGSIFGE--ALRRVWI---YLARDGHSTS-F------KFE------LIYSKG-FK--SQLLCMDQFYCRKL-----RFF-VT------NLAIFWVRIIF------CATISFAPILIFI----FH------SVSQL-PQ------TLEQY-I----FSGFWLIIT------YLGFVWVMTNAILIGSLITIKLCYFYFKVAHV------ARTV-QN-LALK-RLQ------SNNA----SYLLD-YKA-----T-VREIIRYQNEIEQVNVGIRNLFIVAYLGISFVDNFGIYAAVFVHIDRG------LMDFF-IVNIVMIGFVVIGVCSYTNGVM------LSKMHSCCKNL-RKATRH-L------QL--NVQAFIKVTDLEDRLSRTDIAFTIGKIL-NLTTRVFVIYLIENICLIMM---FKVNLRN------TuGR205/1-453 ------MFFVRFLRFLSF------EFCKIAVRLQKKV---I------PRAKHN------HTEI------VL------KLVRF------VIG-V------HWS-DVDDA------IAVKYLKQL--ESICTTYN-IL-PIQFSR---DPKA------TQSK----LTITKSIL---YSSLMAVNIIHLILLSSFD------LPVEWHHLLGDFFHGHPN-GR---FFWLFFLNGSIFGE--ALRRVWI---YLARDGHSTS-F------KFE------LIYSKG-FK--SQLLCMDQFYCRKL-----RFF-VT------NLAIFWVRIIF------CATISFAPILIFI----FH------SVSQL-PQ------TLEQY-I----FSGFWLIIT------YLGFVWVMTNAILIGSLITIKLCYFYFKVAHV------ARTV-QN-LALK-RLQ------SNNA----SYLLD-YKA-----T-VREIIRYQNEIEQVNVGIRNLFIVAYLGISFVDNFGIYAAVFVHIDRG------LMDFF-IVNIVMIGFVVIGVCSYTNGVM------LSKMHSCCKNL-RKATRH-L------QL--NVQAFIKVTDLEDRLSRTDIAFTIGKIL-NLTTRVFVIYLIENICLIMM---FKVNLRN------TuGR206/1-456 ------MFLVQFLRFLVC------EFRKIAMRLQKKS---M------LRVKHN------HTEIGSE------IS------KLICR------VVG-L------RTF--VDDV------IAVKYLKQL--ESICISYN-IL-PNGFSQ---DPRV------TPSK----WTTTKSIL---YLSLMTINIIRLILLSCFN------LPDKWHLLLGDFFYGHKN-GR---LFWLFFLNASIFGE--VFRHFWI---YLIEKKQWES-F------KFEQ------IVYSKG-FK--SQVLCMDLFYCRKL-----RFF-VT------NLAIFWVRILY------CASISFAPILILI----VH------SMYKL-PH------TLEKY-I----YTGFWLVIS------YLGFVCVISNLLLIGSVNTIQLCYFYFKVAHV------TQSV-HN-LALN-RSQ------SNNA----NYFLE-YKA-----T-IREIIRYQNEIEQANISIRNLFIFTYLGISFVDDFGIYSAVFVHIDRG------FMDFF-IVNAAMIGLVTTAACSYTNGVL------LAKMNSCCKNL-RKATKH-L------QL--NVQAFIKVTDLEDRLSRTDIAFTMGTML-DLTTRIFVIYLLENICLIMM---FEINFRK------TuGR200/1-427 ------M------LKANK------TFLF------IS------KLIQL------LVG-F------RSN-KVDDA------QAIKDLQRL--ESVCIEYN-IL-PNGFSQ---DQSV------TPSK----WTKTKSIL---YSSLIIVNITHLLLLSVSN------LSNEWLLIFGDFLCSYPG-RR---FFWSFWLYVSVFGE--VLRHFWI---YLVRNGNLAT-L------KLYH------SIYLQG-FK--SKSVSMNQTYCQKF-----SFI-AA------NLTILWLRIIF------LTALSLAPIFVII----VQ------TSSHL-PK------TLQQF-I----CIYFWLLIT------YLGLVCTLSNIMLTGGIVTVHLSYFYFKAAHL------AQIV-QD-FVRK-RKI------LDNI----DYFSE-YKV-----T-VDEIIKYQNEIEQLNIRFRNWLIFLYFGISFTSNFGFYIAVIVHIDSG------FLDLF-IASISVVGSVSIGACSYTNGII------LTKMCSYCKNL-RRATRR-L------QL--NVKSFIKGTDLQDRLVRTDIAFTIGKIL-HMTTEVFVIYLLENISLIMM---FTLNFK------TuGR190/1-417 ------MS------KLIQL------LLG-F------RSN-NVDDA------VVIKDMKRL--ESFCIAFN-IL-PNGFAQ---DASV------TPSK----WTIVKSII---YFCIIFANIGHLVLLSVFN------LPDQWLHIFGDFFCGHPG-RR---FFWLFWLYMSIFGE--VLRHFWI---YLVKKGHLKT-L------RLYD------TLYTKG-FR--SQVLLMSPFYCLKF-----RFV-AN------NLAIWWIKVIA------LLTISLAPILVFI----SE------SVSQL-PK------TPQQF-I----YTYCWLFVT------YLGLVCALINLMLTGGLVTIHLAYFYFKAVHV------AENV-EL-FAKK-RRS------SHKV----DYLLM-YKA-----T-IREVIQYQNEIEHLNVRFRNWLIFLYLGMSFTSDFGVYIAAVVHIDHN------YLDVF-LAIVALNGFISIGICSYVNGIV------LTKMSSYCKNL-RKGTCR-L------QL--DAIVSIKETDIQDRLVRTDIAFTIGQFL-DMTTEIFVIYLIENISLIMM---FTVNFQ------TuGR191/1-417 ------MS------KLIQL------VLG-F------RSS-NVDDA------VVIKDMKRL--ESFCVAFN-IL-PNGFAQ---DASV------TPSK----WTIVKSII---YFCIIFANIGHLVLLSVFN------LPDQWLHIFGDFFCGHPG-RR---FFWLFWLYMSIFGE--VLRHFWI---YLVKKGHLKT-L------RLYD------TLYTKG-FR--SQVLLMSPFYCLKF-----RFV-AN------NLAIWWIKVIA------LLTISLAPILVFI----SE------SVSQL-PK------TPQQF-I----YTYCWLFVT------YLGLVCALINLMLTGGLVTIHLAYFYFKAVHV------AENV-ER-FARK-RRS------SHKV----DYLLM-YKA-----T-IREVIQYQNEIEHLNVRFRNWLIFLYLGMSFTSDFGVYIAAVVHIDHN------YLDVF-LAIVALNGFISIGICSYVNGIV------LTKMSSYCKNL-RKGTCR-L------QL--DPNVSIKETDIQDRLVRTDIAFTIGQFL-DMTTEIFVIYLIENISLIMM---FTVNFQ------TuGR192/1-417 ------MS------KLIQL------VLG-F------RSS-NVDDD------VVIKDMKRL--ESFCIAFN-IL-PNGFAQ---DASV------TPSK----WTTVKSII---YFCIIFANIGHLVLLSVFN------LPDQWLHIFGDFFCGHPG-RR---FFWLFWLYMSIFGE--FLRHFWI---YLVKKGHLKT-L------RLYD------TLYSKG-FR--SQVLLMSPFYCLKF-----RFV-AN------NLAIWWIKVIA------LLTISLAPILVFI----SE------SVSQL-PK------TPQQF-I----YTYCWLFVT------YLGLVCALINLMLTGGLVTIHLAYFYFKAVHV------AENV-EH-FAKK-RRS------SHKV----DYLLM-YKA-----T-IREVIQYQNEIEHLNVRFRNWLIFLYLGMSFTSDFGVYIAAVVHIDHN------YLDVF-LAIVALNGFISIGVCSYVNGIV------LTKMSSYCKNL-RKGTCR-L------QL--DAIVSIKETDIQDRLVRTDIAFTIGQFL-DMTTEIFVIYLIENISLIMM---FTVNFQ------TuGR193/1-456 ------MMLTLCKG------VVKLP------M------YMVCLVWYCIQ---SSRKVKM------FHF------TAF------VI------KTFQL------VFG-L------RLT-DFDDA------NAISDLKRL--ESICISFN-IL-PNGFAQ---DESI------TPSK----WTKTRSIL---YSSLMTVHIVHLILLSGFD------LPEDLAFILGDFFYGHRS-HK---YFWLYLLSLTIFGE--FLRHYWI---HLYKTGGPFS-F------HMHN------FVYDKG-YK--PEALFMNHFYCHKY-----RFV-SN------SLTNLWIRTVV------TSSIIIGPVLVII----VQ------SVSQLPPT------APQQI-I----CTYFWLLIS------YFGIVCSVCNLMLTGAIINIDLSYFYFRAAHV------TQTL-HN-FVTD-KLF------LQRS----DFMTY-YET-----T-IRDIILFLNETEYRNHKVRNWLIFLYLGVSFTADFGFYSAAIVHIDNG------SLDIS-IMAISTLSLIAIGGCSYTNGIM------LTMMHSCAKNY-MKVAQY-L------PS--DVLSFMKFTDLQSRLSRTDIAFTIGEIL-NMTTYVFVIYLIENASLVMM---LIINMK------TuGR197/1-425 ------M------FDF------TAF------GT------KTIQI------VFG-L------RLT-DFDDA------DAISDLKRL--ESICISFN-IL-PNGFAQ---DESI------TPSK----WTKTRSIL---YSSLMTVHIVHLILLSGFD------LPEDLAFVLGDFFYGHRS-RR---YFWVYLLNLTIFGE--VLRHFWI---HLYKTGGPFS-F------HMHN------FVYDKG-YK--PEALFMNHFYCRKY-----RFV-SN------SLTNLWIRTVV------TSCISMSPVLIII----VQ------SVSQLPPE------TPQQF-I----CTYFWLLIS------YLGIVCSVCNLMLTGAIINIDLSYFYFRAAHV------TQTL-HN-FVAE-KML------SQRS----DFMPY-YET-----T-IRDIISFLNETEYRNHKVRSWLIFLYIGISFTADFGFYSTAIVHIDHG------SFDFV-IIAISGLSLIAIGGCSYTNGIM------LTMMHSCAKNY-MKVTKY-L------PS--DVTPFLKFTDLQSRLSRTDIAFTIGEIL-NMTTYVFVIYLIENASLIMM---LIINMK------TuGR198/1-427 ------M------KK------FDF------AAF------GT------KTIQI------VFG-L------RLT-DFDDS------DAIKDLKRL--ESICISFN-IL-PNGFAQ---DQSI------TQSK----WTKSRSIL---YSSLMTVHIVHLILLSGFD------LPEDLAFILGDFFYGHRS-RK---YFWLYLLNLTIFTE--VLRQYWL---HLYKTGGPFS-F------HMHN------FVYDKG-YR--PEALFMSQFYCNKY-----RFI-SN------SLVNFWLRTFL------SSVISMGPVLVII----VQ------SVSQLPPT------TPQQF-I----FTYFWLLIS------YFGIVCSIANLMLTGVIINTDLSYFYFRAAHI------TQTL-QN-FVND-MIF------LQKN----DFLTY-YES-----I-SREVILFLNETEYRNHKVRNWLIFLYLGVSFTQDFGFYSTAIVHIDHG------SFDSV-IIAISGFILFAIGACSYTNGII------LTMMHSCAKKY-MKVTKY-L------PS--DVITFIKFADLQSRLSRTDIAFTIGEIL-DMTTYVFVIWLMENASLIMM---FIINMK------TuGR194/1-440 ------M------YDLTDWKQRI------ATV------FPFNG------AKSI------VI------KAIEL------VFG-L------RLA-NFDDE------IAIKDLKRF--ESICVSFN-IL-PNGYAQ---DESI------TPSK----WTKTRSIL---YSSLMTVHIVHLILLSVFD------LPEDLALILGDFFYGHRS-RR---YFWTFLLNLTIFSE--VLRHYWI---HIYKTSGPFS-F------HMHN------FVYDKG-YK--PEALFMSQFYCHKY-----RFV-FN------SLANLWIRIIE------ISVIGIGPVLMII----VQ------STSQL-AK------IPQQF-I----FTYFWLLIS------YFGIVCTVGNLMLTGAIVTTDFSYYYFRACHV------TKTL-HN-FITE-KMF------LRKN----DFLPY-YET-----I-IRDIILSLNETEYRNHKYRNWLMIIYFGVSFTADFGFYSAAIVHIDNG------SLDIS-IMAISALSLFVMGICTYVNGIL------LTMMLTCSKNI-LEVAQY-L------PP--DVKSFIKFTDLQSRLSRTDIAFTIGDIF-DLTTWIFVIYLIENASLIMM---LTINVK------TuGR195/1-440 ------M------FDFTDLKHCI------TTV------FTFSG------AKAI------VI------KAIEL------VFG-L------RLA-DFDDE------EAIKDLKRF--ESICVSFN-IL-PNGFAQ---DESI------TPSK----WTKTRSIL---YSSLMIFHIVHLILLSGFD------LPEDLAFIMGDFFYGHRS-HK---YFWPYLLNLTIFGE--VLRHFWI---HLYKTGGPFS-F------HMHN------FVFHKG-YK--PEALFMSLFYCQNY-----RFV-SN------SLVNLWIRIIE------ISVIGIGPVLIII----VQ------STSQL-PK------TPQQY-I----FTYFWLLIS------YFGIVFTLINLMLTAGINTTDLSYFYFRACYV------TKTL-HN-FVTE-KIF------MQNN----DFLPY-YET-----I-IRDIILFLNETEYRNHKVRNWLMIIILGISFTADFGFYSAAIVHIDNG------SLDIS-IMAISALSLFAIGITTYVNGII------LTMMLSCSKNN-LEVAKY-L------PS--EVKSLIKFTDLQSRLSRTDIAFTIGEIF-DMTTRVFVIYLIENATLIMM---FTINVK------TuGR196/1-456 MEGNF---KRFIVLLLRAA------INA------FNCPALKYCI------AKV------FDG------TKAI------LM------KAIES------LFG-L------RFT-DFDDE------DAIRDLKRF--ESICISFN-IL-PNGFAQ---DESI------TPSK----WTETKSLL---YSSLMAINIFHLILLSVFN------LPENLSLILGDFFYGHRS-RK---YFWPYLLNLTIFGE--VLRHYWL---YLYKTGGPFS-F------HMHN------FVFDKG-YK--PEALFMSFFYCHKY-----RFV-SN------NLANLWIRIIK------MSGIVIGPVLIII----VQ------SASQL-PK------TPQQY-I----FTYFWLLIS------YFGIVCTLTNLMLTGSIIIIDLSYFYFRAAHV------SQTM-QN-LVTG-KIV------LQRS----EFLTY-YET-----I-IRDIILFLNETEYRNHKVRNWLIFLYLGISFSADFGYYSAAIVHIDHG------SVDFV-IILFSGLSLFAIGICTYVNGII------LTMMLSCGKNI-LKANKY-L------PS--EVKSLIKFTDLQSRLSRTDIAFTIGEIF-DMTTWVFVIYLIENATLIMM---LTINVK------TuGR199/1-437 ------MNW------FHFTTMKHCI------PKV------FTFAG------FKAN------LI------KAIQS------VFG-L------HLT-NFDDS------EVIVILKRF--ESICVSFN-IL-PNGFDQ---DQSI------TPSK----WTKAKSIL---YSSLMTVNIVHLLFLSVFD------SPEHLSIILGDFFYGHPS-RR---YVWIYWTILLIFGE--VLRHYWI---YLYRNGKSFS-F------RWH------KG-YK--PEALFMSKFYCHKY-----SFI-AS------TLANLWIRAIL------LFGIGLGPVLIII----VQ------LVSQL-PK------TPQQF-I----FTYSWLLID------YFGIFCTLANLILTGAIITIDLSYFFLRCAHV------TQAL-QN-FVDE-KMC------LQRS----NFLPY-YET-----I-IQDIIVFLNQTESRNHKVRNWMIFMYLGISFSADFGFYTAAIVHIDHG------SLDFV-TIAISALSIFTIGISSYVSGIM------LAMMQSCYKNN-MKVAKY-L------PS--NVNSFIKFADLQSRLSRTDIAFTVGSIL-DMTKWLFVIYLIENAGLVMM---FIINVK------TuGR529/1-440 ------M------FNVKTLHCHK------NKV------FTTDK------AKKF------LI------KAIEP------VFG-L------RLT-DFYDA------DAIKDLKRF--ESVCISFN-IL-PNGFAQ---DQSI------TPSK----WTKTRSIL---YSSLMIVNIFHLILLSVFD------LPQDLSLILGDFFYHHPR-RR---YFWLFWTNLTIFGE--VLRHYWI---YLYKTGAPFS-F------HMHN------FVYDKG-FK--PEGLFLSHFYCLKY-----RFI-SS------NLANLWIRTII------ISGISMGPVLIII----VQ------SASQV-PK------TSQQF-I----FTYFWLLTT------YLGLVIALTNIMLTGAVITIDLAYNYFRAATE------AQAV-RN-FANK-GGV------LNKR----IYLSE-YKE-----I-SGQIIHFQNEIEHINLKIRNWLIFLYLGVSYSTNFGFYLAAIVHFDHG------PLDIF-IGSISILGLFAIGTCSYVNGVI------LTMMHSCGKNI-MKANRY-L------PL--GIKSSIKFTDLQSRLSRTDIAFTIGTIL-DMTKRVFVIYLIENASLIMM---FKVNVK------TuGR182/1-419 ------M------I------RVYNY------LLSTVK------SKK-RQPKDHF------YGVKYVSYL--DKMIVKCH-FL-NQGLTT---ERRPMK------QMILYEIS---LFIINLFTVVRLLLVLFWDE--KSPVYSQLVLYLGEGYIGLPN-RK---LVLTLFLLAQSCFW--LIKLTSL---WCELTNNMKI-L------DELA------VVRKSG-FD--SDALKLRNEDCKRF-----QKI-SI------VILGNIKAIII------ILCFSVSSIHIFF----QQ------SCWHF-LN------GLTAK-T----LTFIWSIFI------VTMICMHTTVALIGTALLLFGFSYVKFRHDSI------TSNL-KL-LSKL-SA------CPVA------I-LQR-----T-IYDHIDIYNLFDLCNVFSRPILFVMYVPFTLFADLTFFFVTVHGVDSK------FVSYV-ATVIISIAVAGFALSTYLIGNI------HSKSSMASKQL-HKLILH-A------PF--NVRVNLKALFLLERILETPVGISSYNSV--VTKEHVVTYLLENASNLML---FTCNFRRV------TuGR181/1-410 ------M------PLIKK------RRR-DDSLD------RGKKCVEYL--DDKVKSFH-FL-NQGFDL---KLRPIK------RLIAYEFS---IFLFNLIWFIRLLTLTLITK--DSVYYEKWTAYLGDGYISHES-HN---LIHFLLVLTHIAFW--SIKCASF---WYELGHEIKV-L------KDLN------IIKIYG-FD--RVALKMRFDYCRLF-----QKI-TI------FILTKVETAMI------ITSLILFLAHLYQ----IQ------ASWYL-MK------DWLQK-L----FVITWSIHF------IIIIYLCISIGYIAAALMLFGCLYVKFRQDTV------NANL-DL-VKNL-KI------CPVE------L-LEQ-----L-VRCHSEVYNLIDRGNLVSFPVTFLIYVPMTFIADICFFLGAIYKVDDG------QLNFI-CMAFSSLAIVVFAYVSYLVGSI------HEKAQRASKSF-HKLIIR-T------RF--RRRSSLKTLFLLERILETPIGITTPTTV--IKKEFFITYLLETASNLML---FICNFRRD------TuGR179/1-431 ------M------LETGVGRNHDNK--IMPLLTP------KVFEQPS------VKF-DKSSD------RGKQYGEYL--DDKLKNYH-FL-NAGLDL---KLRQMK------HIIAYESS---IFIFNLIWSIRLLTLALITK--DSVYYEKITAYLGNGYISHES-NR---LIHFLLMLTHMAVW--SIKFAGL---WYELTKGIII-M------KDLN------VIKIYG-FD--RLALKLRFDHCRLF-----QKI-TT------FILTNVETSMI------ITLSILFIGHFYQ----IQ------ASWYL-MK------NWLQK-L----FVIIWSIYF------IFVLCFIIAAGAIAAALLLVIFLYIKFRQDTV------NANL-DL-VKNL-KI------CPIE------L-LDQ-----L-VRCHSEAYNLIDRCNLVTKLTFFLIYVPMTLVADICFFTGAIYNVDDG------PINLI-CIFFSSVAISIFAYVSYLIGSV------HEKAERASKSF-HKLITR-T------PF--NARSSLKTLFLLERILETPIGLTTPTTV--INKEFFVTYLLETASNLML---FICNFRRD------TuGR180/1-443 M------CLKNPILIIIE------M------LETGACRNHNYK--KMPVLAT------KVFATSS------IKF-DDSSD------RGKKCVEYL--DDKLKKYH-FL-NQGLDL---KLRPMK------HIIAYESS---IFIFNLIWSIRLLTLALITK--DSVYYEKITAYLGNGYISHES-HQ---LIHFLLMLTHMALW--SVKCAGL---WYELFHEIKI-L------ADLN------IIKVYG-FD--RVALKMRFDHCRLF-----RKI-TI------FILTNVETSMV------ITLAILFIGHLHQ----IQ------ASWYL-MK------DWLQK-L----FVIIWSIYF------MFVHSIIIAAGYIAAALSCVVCLYVKFRQDTV------NANL-DL-VKNA-KI------CPVK------L-LNQ-----L-VRCHSEVYNLIDRCNLVVYLVTFLIYVPITFIADICFFTGAIYNVDDG------PINLI-CIFFSTLAISIFAYVSYLIGSI------HEKAERASKSF-HKLVIR-T------PF--NLRSNLKTLFLLERILETPIGLTTPTTV--IKKEFFITYLLETASNLML---FICNFRRD------TuGR210/1-403 ------M------SLL------NFIKDWW----LEVLH------PKK------F-----SGSSRSLLSFDIERSMAIMG----VTTLNQ------IKSMR----YYKIYDLI------LHFINLIKYLTLYT-I------SNPHYLVTVSDLTITFGQ-YR-SWALNLYFFTYTAISG--VWYRFEL----FPANGKYFSWL------TLYS------QSVSPNESQK--PEWIQL------KWK-VN------LIWNLLQYSLI------YGTALPHFA----LL------VSPSI-YA------T------NGWQL-I----ICLTFSLIA------MQRLLFLCKAIGNILFFFSTFMMILDYKLKVW------RS------FNEG------L-FKRTDWVNY-LRKFMSINHTFQSGNRVLSRIAGLFYAQAFITVIINMYIVFFITTPLG------VKVMTTVSLTVALSMITLPPVF---CRAAIQSNKLTQKVLRKAAFV-D------ES--SISLRLKAQSMMEFNKRYPIGITFFDIT-PFDTKLFINTLLEMSSYMFL---LVIQTRQQERNETYN------TuGR31/1-411 ------M------VF------K----RFLNY------MLI------PKSYRT------PDPNRLLEYDLENDLTHLH-LI-SFHLPS------IEPVK----SRTIINLI---FDIFCWINAIKVAWFYW------LDIPTAIRFGDLSLFYGE-SRYYGLAYGVIGFVYINVA------YNVAH-WDPSHVKSYYWL------RNYN------EP------FP--DHHYFVQHPVKARWAV--IKKR-VNRVY---LFLWFVTRCVIIPS---ATFVALSPIFMSKQASDLI------TN------VPSA-ILTLYA------CFYAFNLVRMSVFLAISYGFIMHY------SL-----ELNLKYL-RN-LKTK-KT------VNYS------Q-LRT-----F-FQHYLNIYNEAFEANKFMSKLSGVLYSGTFLESLVCIYVAFIAPES------PVSTR-MLFLGFFNLHLTLNIILMSLAFI----YLQRLDQLVRNNIHKLLTR-S------II--KPALKIKLEEALFMMESYPMGFRCFHFF-RFNSSSLLLTLLELGAHMLL---IVMSVPRVTH------TuGR32/1-411 ------M------IF------K----QVLNY------LLI------PKSYRT------PDPNRLLEYDLENDLTHLH-LI-SFHLPS------IEPVK----SRTIINLI---FDIFCWINAIKVAWFYW------LDIPTAIRFGDLSLFYGE-SRYYGLAYGVIGFVYINVA------YNVAH-WDPSHVKSYYWL------RNYN------EP------FP--DHHYFVQHPVKARWAV--IKKR-MNQVY---IFLWVVTRFIIIPS---ATIIFLSPIFFVEQAVDYI------TN------IPSS-LLGLWA------GFYAFNLVRMSVFLGISYGFIMHY------SL-----ELNLKYL-RK-LKTK-KT------VHYS------Q-LRT-----F-FQHYLNIYNEAFEANKFMSKLSGVLYSGTFLESLVCIYVAFIAPES------PIFTR-VLFLGFANLHLTLNIVFMSLAFI----YYQRLDQLVRNNMHKLLAR-S------VM--KPEVKIKLDEALFMMEAYPMGFRCFHFF-RFNSSSLLLTLLELGAHMLL---IVMSVPRVTN------TuGR576/1-408 ------M------IL------K----KLFTF------LLP------RKVD------QHPNRLLNYDLEDDLTNLH-LI-NFKLPS------IEKVG----HRHVNNII---FDVFCWINSIKVVWFYW------IDIPMAKRFGDLSLFYGE-SRYYGLAYDAIGFTYINVT------YFIAH-FDHFQRKCFHWF------RNYN------QI------FQ--SDHHYVNMLNRSRWNR--VRKL-INLVY---IYLWIFTRFLVLPA---ATVIYLSPMFMVDHPMDLL------TN------VPAA-FLACWA------GFYAYNLVRMSVFLGISYSLIMHY------SL-----ELNLDHL-RK-LQTR-KT------IAYS------Q-VQT-----F-FHHYLAIYNEAFEANKFMSKLTGVLYSGTFLESLVCMYVSFIAPS------PLSTR-IIFLGLLNVHVTLNIIIITLTFI----YPQRLDQMIRNNIHKLLTR-S------II--KPAIKIKLEEALFMMESYPMGFRCFHFF-RFNSSSLLLTLLELGAHMLL---IVLAVPRVNH------TuGR33/1-434 ------M------PKKV------KRQ----QLIQE------QLINHYT------NSLEN------RNRRRVDLDMFDIEEHLYYWT-IIPSLTPNQ------PAKRL---ILPIGSII------IQFLGLVKYMILLFVG------YDDFWVYWLGDITVDFGN-AK---DYCDLCFAIWALST--ITSQICFV--SSYLKNNLYW-L------TIFRL------FNQPPPRIFKSSLQKNVFTQIY-PKM-VK------ICRIGWYMLIV------TTSGMILASLVLLRFG-FV------YL------I---TIGFIQTLLS------LSNCYITTVFVGLISIIFSLVCNQYRLWCRLIKQNLVNYEKRNI-RR-IATS-QST------VNHL------H-FYQ-----FIIREYCCFHNDLLHATKFWNRSISGLFLGCSASSVLVVYLYFFVDMEP------STAIA-ITIFGLCTFFNGCLINVLAPAN-----FRHNLQRLSHPM-HRLMRL------DL--SIGMKLGLTVILDDIINNQC-FTCYGMF-QYNYMLMIRLLLELSTLMLL---LISSKNGSKTYNININQ------LN------TuGR213/1-453 ------M------QHQF------EQRK------SFS------HPS-SNPKE------GLYGNIPKLSYETWFKIFG-LL-SSGLDH---ERRFGPIKQDRTPVK----IKRLYCQL---ITAMLWFFAVRGFVLMF-I------DDKGLAILMGDLSVYWND-YR---MYYLMPTFYYAFSSA-LVATTFL---LKERDLSWFIPF------MTFS------QHQSTDPNDKLGF-----HRW-RT------LIFTLFNLTITMW----VTGSMGYLTYSSARD--NM------DAHTF-----RLFMPWLVVQ------VIWYFFMTGIIMFTTSYFNLVCLMVQKKFSDV------ASEI-ET-LAEG-DPGPPG------SKND------D-LTR-----L-YFAHNDLCEITDESNSFWQYILFYIIGNFIPNFCYVMYTLFFGDLDTP------LAIFS-WFILG-HTFLIMAVLSVSAADV------SSEAHAPYTSL-HTLSLL------QL--PIDIEVNMSTFLHRVRGPTIGYSILDLF-VITNSSISNTVAAIASYFLI----VADFSRSTVN-----QGLIQKAQSKQKAINESLAMTTTSSMLDATTIASIG TuGR214/1-456 ------M------VK------QIRYK------QSTVS------PTNLDESVQD------STVKSPYVY--TQFWLKLSGVL-PLKSVQ---DGQKGIK----IMST----IYSLYCRL---ISSMLWILSIRAFILMF-I------DDPKLAFKLGDLTVLFTD-NR-Y-IYYRMVYFCWSASAT-LIATSYA---LDETQSCLVP-F------NTFN------SSRLNHYYN------TTTY-----RKL-KY------LLTICFCWVIIVTITGVLSHLHYQSMIIYN----LL------SSPSW------NPI------DLANLNV----NPSFWLILH------AIWYFYITSIVVFTAFHFSLICSVLEQQFDLV------TSKT-EL-ILYS-DNIKLD------LKDS------SLLSQ------YVEHNYLCETLIKSNSFWKSVISTISGFYIVNLCYIFYTLSYGQVNLN------LFTFY-CLIAG-FNFLILYLIFFPAAAV------AKKAFAVNTAL-YLSGSE------FLPSFIYVESFILRLKC-TIGYSAYRFF-VIKYTTIGAVISATITYFLI----VADFSRSTGSSTPTNDTDIDVSLSYNRTLFTNPFFINISS------ESG TuGR215/1-437 ------M------QQF------EGRRSLGD------KDD------LQ----DQPCGK-VPYELWLK------LFG-L------IDN------SLIDKVRDA--ANKGVSLE-TL-TNPSAP---SNK------PSSE----KTSLKRLT---ILTILTLVLVKRAFTMV-N------PNLMINTYLGDVTGYWLN-TT---VYFQFPLFVYILTALFTMRRFVS---HEKDLKCFIP-F------APIPEIP------IP------CQCY-----KKI-RYKT---RIRFMTLAVVVI------VLTLSLYPAYPTIK---TI-YF--D-PNPFIEYR------I----LILVWVIID------CFANLLALGIISFSLLYFDCVCLVIGNKFRSV-EDI----IDETALRCLKKR-KEPQ------IFSS------LTE-----L-FNTYLDVNDICTDSDSFWGKVAFYIIFCNTALFLFVTYSFIYGENNSNL------KIYYIMVWSNSLFVLYKICQSCYDVS------YASAKRGYDNL-SKINEF------EA--SKIVMMKILAFRRYMDSESIGYS-GIYT-KITYETLFSWMFLIASLFLI----IMDFANGTLP-----TGLSMKYL------TuGR212/1-410 ------M------KFK---FKFPYD------FIFN------PKV------EKDQNFERF-ISSLTPIYS---PTGGIN------RLKSIAIF---LSFYAIGSIKQIICLFV-T------ADDETLILLGDPFQPFGT-NR---LFLDILIAGWIVLC--FINFLAD---TYNRNAKATI-FWSKQMASIFEEYPLPSWRVDKVHHLG-YDD------YIDVCNKF------RLVIRYARFTSL------MSVLSVCGYMTPT----MI------ANPDYW------L----INLNWTLFY------IIAGTISILRLIIYPCIFLICVYTFNYKLTHI---FVPLKINQL-SK-IDEN-TLIP------VRET------NTISD------MKIMAKLYKEMFTYNKYWSVVNGFGHCMSFMINSYILYPIFFI--EST------LITRL-ICVYWTILCLLWFAFPYLTVSY-----MNFKISRVNKRI-FSKIKDLA------NPFEGIRLMVTMEHISEFK-GFSIFTFH-EPSYISFVFQSLDLITYFCL---FIQNLGRAKSR------TuGR211/1-443 ------M------LRLNQIE------RVKMFFNR------FN------RLISF------LISHLKNVITHLISN-NLNDQ------SIIKTMLKC--EKSALKFV-GT-INGYST---GSPPQ------KQLLKHKL---LKGLVLIVLIRATFLVLIPSTPDCELCNTISLFLGDNTSCFPK-RN---LLAIMLLLAVICLS--MMFTDCH---RPFEKSTVSF-F------HIFT------IIMSTSSIS--NHLLDIN-LHSSQFQL---RLL-LK------SMALFQTTCYM------LSSGYVIFFFNGS----FK------CLPGQ-YL------SLQTF------CQIFWVVMN------SIATTTSIFSSIWFYFHALIYFLYILLRLKEL------ILIE-DS-TQTN------IASS------R-VYR---INW-IAKCNAIFNNIESGNREIRSMALTTFSSLALFINFTLFVCFIVGVDDPMVRW-PILIPVT-LSLIGIIIFVRILVVD------ANNKIDRLTLII-YRLARN------ST--KLTVKIKSLTTIDRLTTKPIGFYIGETF-RIESLVLLKIIFENITIFLL---LIDAFKKQT------TuGR4/1-412 ------M------AVRIESV------IA------FFGCF------P------IYLADYLANKGKSK------KFSQI---LTTVYHNL---AKYLSLCLLLITILVIP------PFSDYTATLIKPEND-RN--SPFYALIVSNLIS----NVSTYFIAGYASNSNSILMKWT------EIFQ------FLTQSK----VSSKIDNAPDTMQKL-----SSF-AHQSALKCIYSIIVRALII------ITILTLLYLYEGL----TL-SFT--V------YG------NNQLI------QLTLFTLLT------IHLTIFASLDHV--NSHLFEILVQYFVLKFRVI------NDRI-AV-IVKK-GKDGSNNQ------IKSLDEA------E-LKS-----I-LDEHDLLKVNLKLYDKYWSQINIVTLILKPLTCLYCVFQLTFIVQSTAS------IV----FLWLHLIESVYLFTKMFLSGTK-----VSDEIDSVAANG-LRLILF------SY--SIPVLQRLQLFNQHIMFTEMGFSCGGLF-IFTLDSVHDAFIELTQDFLLTLDFVITVRQAKSQLN------TuGR216/1-429 ------M------AESLSSDEKINVETTIKPFA-LF-PLNFDDYNVEKRK------QSSG----FAKIYHML---IKAFILHMLIRSLFVLW-Y------EDDYFRKLLGYSYKAYPY-LD--WVVIFYLTYTYAILYV-GARS------CKNNTYNMEF-V------EIFK------VLNGTK----LPQEIGTNIKIVESL-----SRY-AH------SKMASCRYIIG------VRTVIGSIVFASI----YL------DNTPL-LK------SG------GIEEVDY----YSVAWGVLL------TLFVFICSGVIYVTINLFDILGYYFQLRFHKV------NQDI-ES-IITARESPTSN------VKVV------ELMRQ-----I-LIEHDSLCWKLDHYNRYWCLIVMITFFVQPTIFVYTMYEICFM------WQT------WGALGLLWALNLESAYLFTRMFLIGVALSDEVHHIYLRA-VRASFA------KY--PLDLRLQIRIFIQRISGATIGFYCYDLF-GLSRHSFYHALVHMGQNFFLIIDFVVSQKQAREQIAIERAARAAALGN------MAG TM 1 TM 2 TM 3 TM 4 TM 5 TM 6 TM 7

intron 1 intron 2 intron 3

Conservation ------1------10------00000------010-0------00000------153417135--53443251-00-000001---1000------0000----43222354---41444442448445744-0------342051566+83432112-21---34346414444432--4441544---2422323514-4------2051------00033-11--00010100000001-----422-43------45434422444------4433443362431----33------24000-00------00000-1----414645432------45544454454544444444143624244137------2314-21-4312-00------4002------1-511-----5-411251346142142125416444434445416452774545404110------44314-7444744543454445744414------21541244225-337413-0------14--130524+252436653232636377444-273312492657+5772799---735+64000------

Quality

Consensus MER+++TIFMFF+KFL+FLYCIAS+++++++++LKSVQKIFSFFMISQLLNMKIISSNLTNEKFKMFKK+KAKA+AMM+++NF+++++FAFANLRFIIFI+SAAKVKSFE+QS++KPNLKKKHYS+SMRLFRKNYFLKYLK+F+PNYL+FLKLG++R+ASIKNVFIKLISKFS+++HIKLIGKLTGVI+QQPDS+NESDEDLFMACS+LE+IKALKRFL+ERLTIIFQVILPRNGLSQCNQDNSVQS++++ITVNKFGYRRFNLKSWLY++IRILSLINIIRLILLIFFTKTPDSVDNETIALYLGDPFFGSKD+RRYKTILLILILIGIIILF+FILREYILQH+YLEAKGKLEIWLWSKQMASIFKE+PLPSWEPCDICRNGSFN+PPVHLQMNNLNCKKFFKKP+RKT+IYASYL+KLLSIFWYRIMIIP+TG++VPIFLAILFITL+A+DLLS+F+S++SNPWLVYKALQNAFIAAVWITCWVCL++N++TFNLALQTPKLA+IPSA+FSLFWSLIE+VTILITVP++IFAFVFLLNSLLGFGWYIIISLSFHLFRLDSLK+++VELNID+A+DKQLLNK+KKHGLSN+F++QSDCCEKK++I+LNEK+EDLDYLLDLIKS++W+NF+NLLIIRLLNEFELANRKLRYLLLYYFLVISFAADFIIFLGFIVRIYSDTVRWQ++FLANL+LAILGILILFSIGIFSYIAGSFIIG++AITKLDSLHKRLIHKLTLKLNDNYGGKKLTHSLKTKLKVLEILDRLAGPYNGFKIGDFLNTITKSFFILFLLENISLLML++DFTVNIGPLI+QSNSS+QGQI+K+LS+++++++++++LN++SMLDQET+SESG

Suppl. Fig. S4. Alignment of T. urticae GRs from clade B.

Alignment of TuGR-Bs using MAFFT v7.266 with visualization using Jalview. Transmembrane domains as predicted by Phobius for a representative receptor (TuGR35, first sequence in alignment) are shown as black rectangles with the positions of the three conserved TuGR-B introns indicated by arrows (beneath alignments). Default tracks from Jalview for sequence conservation, quality, and consensus are shown at bottom. MoccIr143

MoccIr142

MoccIr141

MoccIr138FIX MoccIr140 MoccIr137 MoccIr131 MoccIr139 MoccIr144

MoccIr135 MoccIr136 MoccIr134

100 NMDA iGluRs 0.5 100 MoccIr132 100 MoccIr133

57 90 99

58 MoccIr146 IscaNMDAR03 IscaNMDAR02 85 100 MoccIr145 58 73 MoccIr147 100 TuGRIN3 IscaIR276 MoccIr148 DmNmdar2TuGRIN2 100 IscaIR271 IscaNMDAR01 MoccIr153

100 IscaIR278 Kainate iGluRs MoccIr103 MoccIr101 MoccIr152 MoccIr151 DmGluRIIB TuiGluR9 DmGluRIIC TuiGluR10 100

DmNmdar1 DmClumsy 94 DmGluRIIA 100 MoccIr149 100 39 88 MoccIr150MoccIr154 MoccIr162 96 37 49 67 MoccIr163 TuiGluR1 61 22 MoccIr159 IscaKA05 75 82 27 45 TuiGluR6 100 100 100 100 MoccIr161 DmCG5621TuiGluR2 45 90 DmGluRIID 23 73 89 47 MoccIr160 DmGluRIIE 87 95 100 TuiGluR7 72 5 20 100 83 IscaIR277 TuiGluR5 100 50 10 65 MoccIr164 DmCG3822 17 6 16 DmCG11155 91 MoccIr155 33 56 DmCG9935 85 MoccIr157 TuiGluR3 81 32 100 IscaKA04 100 71 MoccIr130 TuiGluR4 100 20 34 10059 MoccIr122 AMPA iGluRs TuiGluR11 89 98100 98 MoccIr123 TuiGluR13 62 TuiGluR8 28 100 81 MoccIr121 IscaAMPAR01 100 DmGlu-R1 87 97 MoccIr129 DmGlu-R1B 99 53 94 42 100 27 36 100 MoccIr128 42 76 60 100 MoccIr104 TuIR1 100 MoccIr127 16 86 21 MoccIr120 IscaAMPAR03 DmIR25aIscaIR25a 100 MoccIr126 IscaAMPAR04 100 MoccIr25a 100 100 35 94 9 MoccIr118 91 100 2 21 100 TuIR4 MoccIr125MoccIr119 95 TuIR3DmIR8a 11 22 IR25a IRs 100 72 77 MoccIr113MoccIr124 99 25 63 96 71 68 100 MoccIr116 98

MoccIr105 66 100 100 MoccIr106 29 MoccIr114

32 MoccIr115

36 100 MoccIr112 18 DmIR40a MoccIr117 100 MoccIr110 22

97 77 MoccIr109 DmIR64aDmIR84a MoccIr111 DmIR93a DmIR92a 58 DmIR21a IscaIR93a MoccIr108 DmIR68a DmIR41a DmIR31a IscaIR273

DmIR75a TuIR2 DmIR100a DmIR87a DmIR76a

MoccIr107

DmIR85a DmIR60a DmIR11a IR93a IRs DmIR54a DmIR7a

DmIR51b

DmIR62a

DmIR20a

DmIR52a DmIR94a

DmIR48b

DmIR56a DmIR47a

DmIR67b

Chelicerates Insects

T. urticae M. occidentalis I. scapularis D. melanogaster

Suppl. Fig. S5. Phylogeny of T. urticae, M. occidentalis, I. scapularis and D. melanogaster IRs and iGluRs.

Maximum likelihood phylogenetic analysis of ionotropic receptors and ionotropic glutamate receptors (IRs and iGluRs, respectively) from T. urticae, M. occidentalis, I. scapularis and D. melanogaster as indicated at bottom (sequences included in the tree are as described in the Materials and Methods). The major groups of iGluRs (putative NMDA, Kainate, and AMPA iGluRs) are as denoted with black arcs, as are clades harboring the IR25a and IR93a ionotropic receptors that are broadly conserved in arthropods (orange arcs). Other sequences in the tree represent diverse IRs. The scale bar represents 0.5 amino-acid substitutions per site, and the numbers at the branch point of each node represent the bootstrap values resulting from 1000 bootstrap replicates. 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 cASIC1/1-527 ------MMDLKVDEE------EVDSGQPVSIQ------AFASSSTLH------GISHIFSYERLS------LK-----RVVWALCFMGSLA-LLALVCTNRIQYYFLYPHVTKLDEVAATRLTFPAVTFCNLNEFRFSRVTKN------DLYHAGELLA------LLNNRYEIPDTQTAD----EKQLEILQD------KANFRNFKPKPFNMLEFY------DRA------G-----HDIREMLLSCF-FRGEQ------CSPEDFK------VVFTRYGKCYTF------NAGQDG------KP------RL------ITMK------G----GTGNGLEIMLDIQQDEYLPVW-GETDETSFEAGIKVQIHSQDEPPLIDQLGF------GVAP-GFQTFVSCQEQRLIYLPPPW-GDCKATT------GDSEFY------DTYSITACRIDCETRYLVEN-CNCRMVH------MPGDAPYCTPEQ------YKECADPALDFLVEKDN------EYCV------CEMPCNVTRYGKELSMVKIPSKASAK----YLAKKYNKSE------QYI------G------ENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTVL--ELF------DY------AY--EVIKHRLCRRG------KC------RKNHKRNNTDKG------VALSMDDVKRHNPCESLRGHPAGMTYAA------NILPHHPARGTFEDFTC------TuENaC132/1-785 ------MPLTARR--RMKRKNA---PITPEECKSIYSTDHINFTTTDLPWYCNGIIHGSNSNKFNYGKTYLSSKGIGANVNPHRPSTGLTFGH------VFPS--YQSNQPSHPSPDLHRRSSRGT------GQP------PLSSFRSPSHLPL-PNLFQTGAASPVIIYRDSGPNRPNDLTVLFSDSSVPGLREICHSDSYLR-KIVWFVVFTLLGFLALR-DIHQL----LSEFYNYPVTVDVRLRESRKLPFPAVTVCNL------NIVRFSALCNSTFNF------SMPVELQ------EKLCGTVATALNSKGNSSIEDINDIGEKKPDDEAIEGFSSSAIPDLRSQTSTHPTTTKTGGGPLNVGGNNIGNSATFSGNSGAGNTSNIGAGGPNGPGSSGSPLPPRSKRQAWRNRGGGSGSGSTGNSGNSRPSTGANLTGSKPPTPPNQRTTTPAYDPNLMADEIE-----LTERE--EKELQENLT-TWLAVMANKDKKTTVQLG-----HQFEQMILRCT-IKSTN------CTHIKSFHS------EFTPTEGNCFTF------KSKTWDG------KR------N------KQAKQEETSLA------GVDHGLELVLNLETNEYLPGT----AQV----GALVMVHSPDELGISASEAI------FVGP-ERANYIGLKMLRITRLPSPYPEHCIDHW------PEGLT---ASLTRNSTYSQQACLKICLQKTIQMR------CRCQSAFLNQFE------L-NDTNLRICDTRRKNT------RKCVEEVMLRPESKIDNCMCPPRCQVTQYEKTVSL----AKWPTR------EDRVSFDR------G------SKGLNF------QNLAKVVVYFQTMTMQEVAQQGAWTTAKLLSSLGGFMGMYVGFSFLSLF--EVF------EVIARRIWYS------CTRKRLRFKTI------VQTI------MATLQYKRKQELK------TuENaC133/1-711 ------MINQLVE------LFRTSTIPGFPV------LFSLT------SKPRQYLWILVLIVFLGLTTNSLIQI----VLEFLSFPIIVNVLVADSRVLPFPAVTICNLNPVHRSRFCAYQDENINKPVDVESILCANLDKMLDLCEISSFLNELLDQGREICLPNSVNRRPNRPRPINFPFNNSTRNINR----GRSPISLRTDKIQP------KVGNN------SSFNSRRRLPRGLSLREFI------QGFRMFISGDVVGLFNS------TGLLTGLGVSSLESGSFIDTAI-IQLAKIYGINIKSS-DDLIPALFLKGFADITG------CRFGSVYRSNGSVALEATLRNITDLILNSGCIWKLPRLFSLFQ-NSSE---RLLNGLSSCTAPWVRSVLRVNSSSEKDFDQSESPWYILLDLLQSWLADLSRHHLSVARQLGHQSSDLIVSCHFAGKKCYPIEFESIFSSSYGNCYTYNMAESLISSATLSKPSDQ-KLSG--FTGPKFGLELVLNLEVDQYMPTS----RET----GAKIVIHDRSQKADPDQDAV------HVPP-GVVTYVGIQLINITRLPAPYRDKCSDDW------VEGWVKEWAMTVDHGPYTSQFCLKLCLQTYTLKE-CNCWTVSAPPPYNSTQ------PQCDLR------K------NPVQ------VSCVERVREKYYAGQLICNCPPRCNEKVYEKFIST----GVEAAQ------CSALS------S------GTEESSLDHK------ENIAKVIIYYQTLSFTEITQDVKYTWSSIIGAVGGILGAYLGFSFIAIY--EFF------EI------LT-VALIR------LIFPPKTFTTKIKTRIN------TuENaC46/1-433 ------MKIYYEL------KHLNQILDYYP------FHCLKMFNYL------SI-----LLIRFTCVTLFLA-QFIIL----TQRLLEFNVVHEIDTFVSEDIEVPEINIQIPYQ------YVMDKKILRS------KLGPRFE------AGCKAASS------IQDYDVKHDIGDCDL------FKTD------PQVFSRYIGMHLTLDEIA------RYT------YPNERLIYGFN-SIDVI------EEN--FLT------NGG------CQINRKASA------FYLELVINCS------NST------LKLERTQSLM------LSNYLFSFYINTSFM------QLNLNQPGEPQIDAVSHP-EHSSTSSGK-RASNFIHYNRIFRNLLPSPYRTYCKEY------SQYKEYEDCVHTNSLNQ-TGSLYPLIGVPIEKYS------NKRDLRFYINFE------NNILADIH------KKCRQQTS------QPMCSSIQYSFHYSFV---MDRNLI------DTKP------G------RENIKLTFLLSPKPDSVAKSRPDLSVLDYLILSGSLFSTWFGISIVGQL--MVI-HR------T------VG--LIID-K------HKNQQNVNPSN------TuENaC39/1-430 ------M------ERKTI------FM-----NFIRIFCIVVFIF-QFYLL----TKDYLQFNVRKETINYIDDAIEMPEVHIAIPYY------YALDLNFVL------NNKSSFD------QACGAFFNK------DNCDV------LETD------GGKFYKWLGNILTLSDIE------KYS------YPTETFIKKIV-WSES------SED--PLK------TGK------CKIIRKASS------TTQVLIIRCL------DSHG------LP------LKVSRTKAIIF------NSSVLFNFTLNTTIV------LLKLIYPGKALVDDSSLY-LVCTSAKGK-LTWCGIRFTKHTEISLPAPYKKMCRNY------DRRQTFEDCLNTHSIEQ-TGMLFPETTVPLDRYS------ESSQMRFNSPLY------GNSSSLMLKIY------RQCQSVVT------QQMCNMIRYSYK------MATSSQ------DIAK------D------QQEMRLSFIATSEPDSLTESKPDFPLSDYLILSGSLFSTWFGISIMGQL--LAA-SH------L------LC--IPY------RKSTDTVDF------KTKIRSNSI------SIRPKGK------KSRNNLTITRISPIA------TuENaC45/1-435 M------LIKM------QRKTI------LT-----TFIRIFCVVVFIF-QFYLL----TKDYLQFNVDKEVTNYIDDAIEIPEVHIAIPYY------YALDINLLL------NNKSSFH------QACRAFFNK------DNCNN------LVTD------FATFGKWVGHTLTLSDIA------KYS------YLTETFIKKIY-WSRS------SED--PLK------TGK------CKIIRKASS------TTLVLVIRCV------NSHG------LP------LKLSRAKAIIF------NSNALFNFTLNTTMM------LMKLNYPGKALIDDSSLH-LVGFSTKGK-QTWLGIRFTKHTETSLPPPYKTMCRNY------DRRKTFEDCLNAHSIEQ-TGMLFPGTAVSLDKYS------TSSQMRFNSPFY------GNSSSIIMKIY------RQCQSVVT------QQMCNMVRYSYR------MVTSSQ------DIAQ------D------GQKMRIFFTATAEPGSLTESKPDFPLSDYLILSGSLFSTWFGISIMGQL--LAA-SH------L------LC--KPY------RKSTDKVDF------KTKIRPNRTAIN------TIRPRYN------KSHNNLTI--ISPLA------TuENaC35/1-406 ------M------ERKTI------LT-----KSIRTFCIVVFIF-QFYLL----TKDYLQFNVRKETINYIDDVIEIPEVHIAIPYN------RALDLDFVRI------NNKSNFD------QACRAFFNR------DNCDG------FVAN------SGILIKWLGHALTLSDIE------KYS------YPTETFIEKIV-WSES------LED--PLE------TGK------CKIIRKASS------ATMVLIIRCL------NSLG------LP------LKVSRAKAVVF------DSNILFHIRLNATVM------LLKLIYPGKALVDDSTLH-LVAAVNKGK-QTSCAIRFTKHTENLLPPPYKTMCKNY------DRRQTFEDCLNSHSIEQ-TGMLFPGTTVSFDKY------SGEIRFNLPLH------GNDSSLLEIY------RQCQSVVT------QQMCNMVRYSFA------MSTSSQ------DIAK------D------QQEMRIFFTATSEPDSLTQSKPDFPLSDYLILSGSLFSTWFGISIMGQL--LAA-NH------L------LC--IAYN------RKCTNAVDS------KTSINVYQ------TuENaC33/1-420 ------M------EKKTI------LM-----NSIRIFCIVIFTF-QFYLL----TRNYLRFDVRKEVTNYISNEIEIPEVRFLIPYQ------FAFDLNFLRT------KYNASFD------SICRKLSTK------GDCDG------HLTN------PILFSKSFGHLLLLSDIT------QHS------YPVERFINKIY-WSES------SED--PLE------TGK------CKVTKKASA------SYLLIVLRCL------DSSG------LP------LKLSRSKAVVF------NSNYLLDFSLNATVM------LMKLIYPGKALVEDSSLH-TYAIINKGK-QTSCGVRFTKHTENLLPPPHKTSCKNY------DRRQVFEDCLNNNSLNR-TGLLSFATAVPLDKH------TELHFNSPYL------NQNSSALEIY------EDCLALVT------QPMCNSVRYSFQ------MSVNLQ------DTAS------G------NEQINIRFLATSEFDSITEYKPDFPLFDYLILSGSLFATWFGISIMGQL--LSA-SR------L------LC--LTFD------QRRAVGVEN------PSNEPVTP------ASTLSMMSCPDRDET------TuENaC31/1-410 ------M------ERRKI------FV-----ASIRTFCLVICIF-QFYLL----TRNYLRFDVRKEVTNYIANEIEIPEVRFLIPYQ------FAFDLNFLRT------KYKSSFD------AICRKFSDK------DDCDG------YLTN------SVLFTKSFGHLLPLSDIA------EHS------YPVERFINKIH-WSES------SED--PLE------TGK------CEITKKASA------SYLVLVLHCL------DSSG------LP------LKVSRSRAVVF------NSNYLLNFRLNATVM------LMKLVYPGKALVEDSSLH-TFAITNKGK-QPSCAIRFTKHTENLLPPPYKTMCKNY------DRRQVFEECLNNKSLTR-TGLLSFATAVPLDKH------TKLHFNSPYL------NQNSSALEIY------EDCLALVT------QPMCNSVRYSFQ------MSTNLQ------DTAS------G------NEQIKFHFMATSEPDSLTESKPDFPMFDYLILTGSLFATWFGISIMGQL--ISV-SK------L------LC--LTFD------QRSTIDVES------LNKEPVTR------TRCWT------TuENaC32/1-410 ------M------ERRTI------FA-----TSIRTFCLVIFIF-QFYLL----TRNYLRFDVRKEVINYIANEIEIPEVRLLIPYQ------FAFDLNFLRT------KYKSSFD------AICRKFSDK------DDCDG------YLTN------SVLFSKSFGHLLPLSDIA------EHS------FPVKRFINKIY-WSES------SED--PLE------TGK------CKITKKASA------SYLVLELRCL------DSSG------SP------LRVSRSKAVVF------NSNYLLDFSLNATVM------LMKLAYPGKALVEDSSLH-AYTITNKGK-LTSCGVRFTKHTENLLPPPYKTMCKNY------DRRQVFEECLNNNSLTR-TGLLSFATAVPLDKH------TKLYFNSPYL------NQNSSALEIY------EDCLALVN------QPRCNSVRYSFK------MTTNLQ------DTAS------G------NEQIKIHFMATSEPDSLTESKPDFPLFDYLILTGSLFATWFGISIMGQL--LSV-SQ------L------LC--LTFD------KRRAVDVES------LNNEPVTR------TKGWS------TuENaC30/1-447 ------MVNIESL------NPSVLFMFIS------LRYFQG------IWKFMKMIPVFKKI------LT-----LSIRTFCSVVFSF-QLYLL----TQNYLQFNVRKEVTNYIANQIELPEIHILIPYQ------FAFDINFLKR------KYKSSFE------STCLYFTGK------KDCND------HITN------AVLFSKKFGPSLLLSDIA------KHS------YPIEKFISRLH-WSES------EED--PLE------IGE------CRLKRRASA------AYLVLVISCL------DSTG------SP------IKVSRARAAVY------SANYFLGFPLNATAM------LVKLVYPGKALVEDNSFY-AFAANNKGK-QVSLGIRFTKHTLNLLTAPYKTMCKNY------DRRQVFEDCLNNHSLAR-TGLLYPETTVDLEKYS------QSNGMRFASSSN------DTEDDSLLEIF------ETCESLVT------QPMCNSVRYSFT------MATTPQ------DVKI------G------EESFKFYFIVSSEFDSLTESKEDFPLSDYLIFSGSLVSTWFGISIMGQL--LTA-SN------L------CC--LTLS------RKRTVEVAS------ENSKDETQ------SNRASDD------TuENaC37/1-416 ------M------IFFLKPT------LT-----ISIQAICIAIFAW-QFYLL----TRNYTEFNVRKEVTYYIPNEIELPEIRMLIPYQ------FALDPVILRT------KYKTQVE------KTCSYLTGR------NDCDA------YLTK------PVLFSGLIGPHLLLSDIA------NHS------YAPEMLIQHVY-LSGS------KEN--PLK------SGE------CKLTSQASS------LFMVLILKCL------DSSN------FP------IKISRGKTVVY------STNYLLAVSSNVTTM------SLNLNYPGKALLEDDSLY-TFSSANPGK-EISHKIRFTKHTETSLPPPYKTMCKNY------DRRQTFEDCLNAQSIEQ-MGMLFPGTTVPLDKYS------DSSQMRYNSAPY------NDNGTLFKIY------EQCQSLVT------RPMCSSVQYELK------MSNTVL------DVPK------G------KEQMVLLFSVSPRPDSITESKAEFPLIDYLILSGSLFSSWFGISIMGQL--LAA-SN------L------LF--LAVE------RKSTAVIDQ------PNEAPKPE------VCNEPD------TuENaC44/1-414 ------M------ILFLKST------LA-----VSIRAICIAIFAW-QFYLL----TQNYQEFNVRKEVTHYIPDEIEFPEIRIKIPYQ------FALDPVILQT------KYKSQFD------EVCSDLSTK------KECNG------HLTY------PLIFSKSFGPYLRLSDID------DHS------YAPEMFMARIF-TAGP------KVD--PLK------TGE------CKLISEASS------SCLVLILRCL------DSSS------LP------LKLSRVDAVVN------NANHLFGFPLKAKAM------LLNLVYPGKAAVEDDSLY-VYSSLTPGK-QVTHGIHFTKHTENLLPSPHKTMCKDY------NRRQTFEDCLNSNSSDQ-TGLLFPGTTVSLEKYK------QTNEIRFNAMFR------KDNGTLCEIY------KRCRSLVT------QPMCSSVQYSFK------MSKTIE------DVAK------G------EEKLIFHFSVSSEPDSLTESKPEFPLSDYIILSGSLISTWFGISIIGQL--LVA-SD------L------FC--LAVE------RKKTAVSEN------QNEAVEPE------VINQ------TuENaC41/1-414 ------M------IFLSKSA------LT-----ISIRAICIAIFAW-QFYLL----TQNFQEFNVRKEKTHYIPNEIELPEIRIKIPYQ------FALDPVILQT------KYKSRFD------EVCRHFSVK------KDCDG------HLTN------PILFAKSFSPYLQLSDIA------NYS------YAPEILMPRIF-MAGP------KVD--PRT------TGK------CKLISEASS------SCLVLILRCL------DSSG------LP------LKLSRAEVVTY------SANHLFAFKLNATAM------LLNIVYPEKALVEDDSLY-AYSSLTPGK-QITHGIGFTKHTENLLPSPYRTMCKDY------NKRQTFEDCLNANSIDQ-TGLLFPETTVSLEKYR------KESEVRFNAIFH------TDNGTLLKIY------KQCRSLVT------QPMCSSVQYSFK------MTKTIE------DVSK------G------EESLILLFTVSSEPDSLIESKPEFPLSDYLILSGSLISTWFGISIMGQL--LVA-SN------L------FY--LAVE------RKNPVVSEN------QNEASESQ------VNSD------TuENaC42/1-411 ------M------IVCLKST------LT-----VSIRAICIALFAW-QFYLM----TQNFQEFNVRKEKTHYIPNEIELPEIRIKVPYQ------FALDPVILQT------KYKSRFD------EVCRQFSVK------NDCDG------HLTN------PLIFSKYFGPYLRLSDIA------NHS------YAPEMFIRRLK-MAGS------KED--PLK------TGK------CKLISEASS------WCLVLILRCL------DSSG------LP------LKVSRSEAIVS------NANYLISFKLNATVM------LLNLIYPEKALVEDDSLY-AYSSLTPGK-QISHGIGFTKHTENLLPSPYKTMCKDY------NRRQTFEDCLNANSIDQ-TGLLFPETTVSLEKYI------QTSEIRFNAMFN------ENNGTLLEIY------KQCQSLVI------QPMCSSVQYSFK------MSKTVE------DVSK------G------EESLVLHLKVSSESDSLIESVAEFPLHDYLILSGSLISSWFGISIMGQL--LVA-SN------L------FC--LKAA------RKSTAVSEN------QNESQ------VNSD------TuENaC43/1-410 ------M------IFFLKST------LT-----VSIRAICIALFAW-QFYLL----TQNFQEFNVSTKVKKYIPNEIELPEIRIKVPYQ------FALDPVIIKS------KYKTQFD------EICRHFSAK------KDCDG------HLTN------PILFSKSFGPYLRLSDIA------NYS------YAPEMFIRRVT-VVGS------REN--ALK------TGK------CKLISEASS------SCLVLILKCL------DSSD------LP------LKVSRSEVVVS------NANHLLSFKLNATVM------LLNLIYPGKAAVGDDSLY-AYSSLTPGK-QITHVIHFTKHTENLLSAPYKTMCKDY------NQRQTFEDCLNANSIDQ-TGLLFPGTTVSLEKYR------KASEIRFNAMFN------KDNGTLLEIY------KQCQSIVN------QPICNSVQYSFK------MTKTIE------DVSK------G------EEKAILHFSVSSKPDSLTESKPEFPLSDYIILSGSLISTWFGISIMGQL--LVA-SN------L------FC--LAVE------RKSPVVSEH------QDETMNPK------TuENaC13/1-529 ------MQIFHNK------MFINL-----VVVSSRHLNSL------IWK------NRKSYFGAEMFL------LK-----KLFTLLCIIVCSY-QLYFT----TIDYLEFNVITLLDIDFPDWLTVPDITLCVQFL------DAVNWTAWAI------RHPDLLP------DNCSIIDD----DKE-RSEHI------RECF------AEMG------ADDFEGFVQEHFTVAKFY------KLV------IKAQSLFDLIS-FDSKTGSFNGLQKN-HDIF------CTTRTYLRD------PHVCYHLACR------NGT------NP------SD------DIRFHRSRLIH------SPNPGAMFMFRLYNAFFASCDHV------FLYIHSPLDLPRGPLESY-LVIKPKEK--PSLFLISFILIIDNLLEPPYATNCKDYHHD------DEGTQ------SLIHKYEECLNNQTLKLDPSFVMYQTMIENP------QKVEGNFS------NRLRYKYKDKLNEIR------TECGKLVE------QPQCKVFIYIPY------IIGHER------FVS-QR------EYHSNFIIMAPTTPDIKLEKSPVFLLETYVVNIGSILGIWFGFSMVHHL--GSL-GSH------L------LK-LKNIS-KFSWN------NICLRHEKPLKK------SVY------LNCEQKNQKQNT------AERPAIAYYRTHGL------LSRARAAIAESRKISESRCSQS------IRSRYVTDIM------TuENaC14/1-476 ------M------FI------FK-----KIFTIFCIIVCSY-QLYFT----TMDYLEYNVITLLDIDFPDWLTVPDITFCVQFM------NAVNWTAWAI------HHPNLLP------DKCTIMDD----EKENRSEHI------RACF------AEMG------ADDFEGFVEQHFTVAKFY------KII------IKAESITI----IYNKTEYFNGLEQK-HEIF------CATKTYLKD------PHVCYHVACR------NAT------NL------SN------FVRFNRSRAIH------APTPGTLYYLDIYNVFFKVWDQI------FVYIHSPLDLPRGPFQTY-TVIKPKEK--PSLFFISYIKIIDSLLEPPYATNCRNYHDD------VEGTR------SLMHKYEQCLNNQTLRLDQSFVMYQTIIENP------QEIEANFS------NRLRYKYKDKLNEIR------AECEKLVG------QPECKSLYYIPY------VIGHER------FLNFHY------KLPSVFLIMAPTNPDIELKKSPALLLETYVVSIGSILGIWFGFSMVHHL--GSL-GSH------L------SK-LKNIS-KLVWY------NIYHRYEGLLKK------SVN------SNCEQMNQKQKT------VDLPTIIYYRTHRL------RARADIGDNHKISSN------TuENaC17/1-479 ------M------FL------LK-----RLFTLLCIIVCSY-QLYFT----TMDYLEFNVITLLDIDFPDWLTAPDITFCVQFL------DAVNWTAWAI------HHPDLLP------DNCTIIDD----VKENRSEHI------RQCF------TDMG------ADDFEGFVEQHFTVAKFY------KLV------IKADSLFKDII-IYNKTGNFNGLQRN-HEIF------CTTRTYHRD------PHVCYHVACR------YGT------NY------SD------YIRFNRSRLIH------SPNPGAMYHVDLYDEIFKSWDDV------MFYIHSPLDLPRGPLQSY-TVVKPKEK--PSLFLISYIRVIDNLLEPPYATNCKNYHHN------VDGTR------SLMHKYEKCLNNQTLKLDPSFVMYRTMIENP------QKVEANFS------YRLRYKHKDKLNEIR------TECERLVR------QPECKSLHYIPY------VIGHER------YLYFLE------NHQSAFLIFAPENPDIKLKKSPVFILETYVVSIGSILGIWFGFSMVHHL--GSL-GSH------L------LK-LKNIT-RLVWY------SIYHRHEKPLRK------SVN------LNGEQMNQKQKT------VDLPTIIYYRTHHS------RARTAIGDSNRIISN------TuENaC15/1-495 ------M------FL------LE-----KLLTLFCIIVCSY-QLYLT----TVDYLEYNVVTLLDIDFPDWFTAPDVTLCVQFI------DAVNWTAWTI------HHPDLLP------DNCTIIDD----DKENRSKHI------RQCF------TEMG------KDDFEGFVERHFNVAKFY------KII------IKAESLFIDIT-FYNKTGYFNGLQRN-HEVF------CTTRTYLRD------PHVCYHVACR------NGT------NP------SD------YARFNRKRLIH------APNLGILYILDLHNEIFQFWDHV------FVYIHSPLDLPRGPIHSY-TFVKPKEK--PSLFLISFVSMNDSLLEPPYATNCRNYHDD------VEGTR------SLMHKYEKCLNNQTLQLNPGFLMYQTMIENP------QEVEANFS------NRLRYKYKDKLNEIR------TECGKLVE------QPECKSLYFIPY------IVGYER------FLIVNE------NIPSIFTIFAPTNPDIKLVKSPAVLLETYVVNIGSILGIWFGFSMVNLL--GSL-GNH------L------LK-LKNIS-NFAWY------NILHLHEGRM-K------AVN------LNGEQMDQKQNN------VERPTIMYYRTYGL------SSRFRAAIPESRSIIESRRSQS------IRPGYFKETM------TuENaC26/1-469 ------MNSSTAY------KIFIIVCAVCCSI-QLYKI----TRVYLDYKTRTYIDISFTPQIEIPDITWCTQFL------YTINWTHWLI------EHRQLKP------EDCSLDDN-----DTIAVNQI------KKCF------DKMG------QYAFQAYVEKHFTVDRFY------RTI------VKSHSVINGVF-FWTQFGELNGLQDLNEEII------CQTKTFIRD------PQVCYHVACR------NKS------DP------NR------PLYFAKNRLNM------ASNIGSLYQVSVLQEYFKRWEHI------FIFIHSPLFLPHGFEISH-TILSGVDQ--PSTYYLQFRRMIVNLLPAPYKSNCIQYRDS------KGKLQ------SQAQHYEQCVNNKTLQLDPSLVFYRTLIVDP------NNTKAHFV------NRLRFKPKYADLLEEIH------DTCRQVTL------NSECRKLFYATA------LIGYED------LIN------SNATLFTIMNSVEPDLNKTTIADFPLGSYIIYIGSTLGTWFGFSMYHYF--HVI-YNK------LK--PLTV-RQ------EKRKKKMNK------LVKHKEGKKMDS------VGVSFINLHDS------QRTIQP------YIESIKRPKQRQ------TuENaC24/1-444 ------MI------RNSKIIL------YN-----RIFLFVCLTGCVI-QLADI----FRNYIQHSVVSKVILSYPASITVPDLTVCSEYI------DVINYTAYLT------TCPDKIP------TECASVDV------STEDGL-----RHCFA------DVVG------FNKMRSFISSTFTVAQFY------NLT------YSPKTIFPQVD-LSA------KFN------DSR------CSITSLFAS------NRICYTIQCSYG------SP------LTITRYTLTE------GDLKGAMIVITVNQSIVRDWEFT------FVYVHEPFTFPYGYESSW-VGLTFNRL--PSLYLIKYKLIKVDLLPKPYVTACRDYE------SIGFD------NRLDYFDHCINQSSLEY-FGLPSHRTFMY------PTLNISFPSHQL------NRQSAAYRVIE------NNCIAEIS------QPQCHYTFYIAS------NEGWYP------TD------DNTSKILLLAPNEPDLHAITLPAHGFYQFLIFVETILGIWFGFNYFGYG--QKI-FSS------LYEYSKIEPKLRWQQIK------KQMLLGKLGSKSKQ------EKPNFNRKRSS------KVQVIKVGQP------TuENaC25/1-458 ------M------NFARLICVIGCAI-QLFGV----LNNYFKREVISEVEFKFPRDIEVPDITFCTDFI------NAVNFDLYYN------NQRSKIP------GSCSHVNNSA------DLRSCLI------EKFT------IKEFTKYISQQYTVNAFYA------DLI------IWPINIFEDIKFWIDSHES----FKN--PFK------SGL------CGITPYIRE------PLMCYTVHCK------NSSSTGK------ISP------LTVKQQDLRM------SPTLRSILRIKFNETIFDRWDRT------WIFLTPPGTLPRGFESAY-LILRRAAGK-TINYYISYKRVHVELLPYPFKSNCVYYNE------TFNGR------TRLELFENCLNHLSNQR-LGTIFYSTFNS------VEVNSTLA------SPLRESSRYLHQYHKIE------KQCSKLID------NPECISEYFITL------GLGYQV------LNKTS------DQSTQLTLLAPTEPDLIKKSKPAFIIFQVFLYAGSVLGVWLGFNIVSHT--GQI-IL------L------SGNRDEVKSNPNGHQ------DQKI------LFTKKTVRNRPKKYFKTIKVSLLLIE------IFLSFTEKAIS------TuENaC29/1-499 ------MKSDWKN------TGNPIEPKPASKPK------SQKTQWYYI------LD-----LIILIGATIGCIY-QTILV----TTVYLEQQVITDIRIQFSDVVRIPDLSICLYFY------NFVSYSNLKG------KEPKIFA------RLKSKFPT----VTNQSTFNEWKFS------SD------AITFLTVEFSRLTVSQMM------ETM------IETHQLIEKVVPTIRQIDL----VNN-VNLD------DVND------CSVQTTVKE------PYICMTVNCPIL------SY------HQLQQKDLEL------TKYLGTVIAIYFNHELFATTEEY------YVYLHPTGTLPYGTQMSS-VTIVTEEN--SHKFFIEYKGFQANLLPPPYTTKCKNYT------LDGFK------SQNHALEACRNNASLER-FGCGFYSDVMN------ANSNARLGISDY------YLNYGDPRRRKVINEIY------DNCSRLHW------APDCRQKYFVPR------IQKVAR------ID------SSSDLLCLSMPTEPDITNSCLPKLPLFEYLIYLGSILGTWFGFSVLSSS--PAI-FK------W------AF--DLIG-VLTSSRPT------KGHILRNTNVKGKS------RGKLKDRRSSSGSSKN------FRQSV------EAMKGIRQLRPKVH------YWDDYFR------TuENaC69/1-470 ------M------AK------LS-----SIIGLFCLIGCIY-QIYDM----TQFYLQFKVRRDVAYDYAPYIEMPAIDITVPMA------IAMNLTKLFA------VYPEEMN------SLCAQLNA----SDAGLNYTTEDFQ-----EKCEVS------MQKA------PIVFSFRLVSFIKVKDIK------EFS------GDLNEQVNQIS-FAKFG------NYT------DL------CNSTRYYNG------VAIFIRLICL------NGT------KP------LSVHTNHV------TLNEGVVAQLTHTFGTHFG------IRFSNQTDLPVFEQGKY-HIITRESGS-FPFSSISFVKTVMSSLEYPYETNCRYY------NKAKSIAKCMTEYSLGQPTPYLFKTLTYEWDQ------HPDHLGFLRKIDQPEDDEITDRDDSEDEDGYSTDLEMQEYYAIINCTEQAA------ATECEKTHYLVE------GENSDQ------TK------SELGLINIEFSRKANLYLSVHPVLPWSEYVIFIGSILGIWFGISIHDRT--LSM-LT------Y------IV--TRFC-KI------KTQTKRATKQ------RKTELNENQRPIQRKLQLKSMKKLP------TFDGRHNYVRNIRLSKNAK------TuENaC73/1-435 ------M------TK------LS-----MIIGLFCLIGCLY-QIYDI----TELYLQFKVRRDVAYEYATYIEMPAIDITVPLV------MHMNLNKLLA------VYPEEMN------SICSRLNI----TDKRLHYTTDTFSVKFY-ETCFAH------FKQA------PIVFSHELAKFIKVKDVR------DFSLLHLA------YDLN-----VF-ITSVG------HFT------KRD------CTSSFYYSG------VAFFVRCSFL------NGT------KP------FSVNTNFV------SLNEGVLLVIDYEIGPYFG------IRFSDHNDLPVYDMSKY-FMITHKTGF-STISSISFVKTVMSSLEYPYETNCRHY------NKAESISKCMTEYSLGQSTPYLIDTLVYKWSE------HPDFLSFN------PGKGHQRVDGKVIGRND-EHYTSINCAQHET------ATECEKTVYLVE------GRSWSE------AL------GKSGQIYVEHTWKANIYLSVHPVLPWSEYVIFIGSILGIWFGISIHDYI--FKL-LT------Y------IT--TRIF-KINEK------QMKTKTKRITNQ------IEFKIGDNQRSI------TuENaC70/1-432 M------CSKM------QVK------VS-----SIIGLFCLTGCFY-QIYDI----TKSYLQFKVRHDVAYDYSTSIELPAIDIMVPMP------MALNYSIILA------TNPEEMN------LICAQLNK----KYKELNYKIDDSH-----GRCEDA-----IPLSILAKD------PIAFSLNVSANITVQDIH------LAS------IDLEHQVIEIF-VPFFG------SLN------HEH------CKTTRYYNG------LAIFMRIFCL------NGT------KP------FSVNTNFV------SRNLGYSYFLRYSFGIHFG------IRLSDPADLPIFERNKY-FMITREPGS-FPVVTISSVKTVMSSLEYPYETNCRYY------NKDKSISKCMAEYTLSQSTPYLFKTAIYEWNE------HPSHLGFN------GDNNDNQRNDGNKVNQG--ELDAFINCNQQAA------ATQCEKTEYLLE------GKISD------QE------MEYGLILFKPSWKANINLSVHPILPWDQYVILIGSIVGIWFGVSMLDYM--LKI-TT------I------IK--TTFT-SL------KHKLNNETNE------IVVDYDYTQ------TuENaC76/1-429 ------MQ------IS-----TIIGLFCLIGCLY-QIYDT----TELYLQFKVRRDVAYDYSASIELPAIDIMIPMA------MALNYSIMFN------PEDMK------LMCARLKE----KYKKLNYTIDDSR-----ARCEDT-----ISLNVLEQD------PVALSLNLSANITVQDIH------LAS------VDLEQQYLEIF-VPFFG------SLN------HKH------CTKTRYYNG------LAIFMRISCL------NET------KP------FSVNTNFI------QMDLDYPYSLRYSFGMYFG------IRFSDPADLPIFERNKY-FMITRKPGS-FPNVTLSFVKSVMSSLEYPYETNCRHY------NKDKSISKCMSEYTLSQSTPYLYKTLVYEWNE------HPSYLGFN------GDNKSDQRNDGEKVSQGTDELNAFINCNQHAV------TNECEKTNYLLE------GKMSEN------GQE------KEYGFIFIRHSWKANKYLSVRPVLPLDHWIIFIGSIVGLWFGVSILDYMHVCKI-FT------I------LK--TRIS-SL------KHMRNETNE------IGNDDCTQT------TuENaC71/1-406 ------M------RVR------IS-----SIIAFVCLIGCLH-QIYAI----TKSYLQFKVRHDVAYDYPTFIELPAIDIMVPMF------MAINWTKVLA------DQP-EMQ------DYCAKLKV----KYEQSNYTIDNRN-----EKCEEY-----IYLMFLEKF------PFVTFDDLPYKIDVKKIK------EDT------FDLTKRVDKQF-AASS------EPL------YLH------CETTCYYNG------LAIFMRIFFL------NGT------KP------FSVSTNFV------SLALGIVASFDCSFPIQFG------IRFSDPADLPSYDSSKY-FMITSVLGS-FPVVTISSVKTVMNSLEYPYETNCRHY------NKGKSISKCMDKYTLGQSTPYLDKYSVHEWDE------HPSYLGFS------DPRNESEKVIHD--ELDAFINCNQEAA------ATECEKTIYLVE------GKILDE------TI------DNRSTIVIVPSLNLNMNRSVHPVLPWDEYVIYIGRIVGFWFGISMYNLI--FKI-FT------G------IK--TRSL-ILRFE------TuENaC84/1-407 ------M------QVK------VS-----SIIGLFCIIGCVY-QIYGI----TKSYLKFKVRHDVAYDYSTSIELPAIDIMVPMF------VAINWTKVLA------HHP-EMH------DYCEKLKV----KYEQSNFTIDNRN-----VKCKEY-----IYLMFLEKF------PFVTFDDLPYRVDVKKIK------EDT------VDIRTCITKLI-VASY------EYK------DIG------CKVTRYYNG------LAIFMRIFCL------NGT------KP------SSVDTNTV------SLNEGIVAYFYYCLPVQFG------IRFSDSADFPSYDQSKY-FMITSKPGS-FPYSTINFAKTVMSSLEYPYETNCRHY------NKDKSISQCMDKYTLSQSPPYLDKYSVHEWDE------HINHLGFS------NPHNEGEKVCQD--ELDAFNKCNQQAA------ATECKKTIYLVE------GKFSDE------VV------GSNSIIIIVPSLNLNTYHSVHPVLPWDEYVIYIGRIVGFWFGVSMYDLI--LKI-FI------G------SR--ARLR------LNVNEN------TuENaC82/1-410 ------M------QVK------VS-----SLNVLFCLIGCLY-QIYGI----TKSYLQFKVRHDVAYDYSFYVELPAIDIMVPMP------MAMDWTKVLA------NQP-EMQ------DYCEKLKV----KYEGSNYTIDDRN-----RNCEEY-----IYLMFLEKV------PFVTSDDLPYKMNVKKIR------DDT------VDLTKLVKPAF-LSWSH------PVT------NRD------CEFVRYHNG------LAIFMRIFCH------NGS------RP------FLINNNLV------LINKGVVAGISYAFGLHFG------IRFSDPADLPEYDQSKY-LMITRKPGL-FPIVKISFVKTVMSSLEYPYETNCRHY------NKAKSLSKCMDKYTLSQYPPYLDKFSVRGWNE------HRSYLGFS------DSRNEGEKVSHD--ELDAFIRCNQQAT------ATECKKTDYLVE------GKFSDE------AVL------GRRGAILIVPSLNLNMYRSAHPVLPWDEYVIYIGSIVGFWFGISMYDPI--FKI-CT------V------LK--NSLT------SKCDCQE------TuENaC72/1-422 ------M------QVK------FS-----WIIGLICLIGCLY-QIYGI----TKLYLQFKVRHDVAYDYSNYVELPAIDIMIPMA------FAYNWTKLLI------EDP-HDD------LYCEQLKI----KYGKLNTI--GYN-----KTCEQY-----FMLYWLEQD------PIALSHSLLATTRLINIR------MDA------FDLRKQV---L-VTSFG------LLT------NRH------CKFTRYYNG------LAIFMRILCL------NET------KP------FSVNTDFV------SLNDGVVASLTYSFGTYFG------IRFSDGNDLPVYDPSKY-FIITRKPNS-FPHVTISFVKTVMSSLEYPYETNCRHY------NKDKSISKCMDKYTLDQLTPYLYKTSVREWYE------LSDNLGFI------GPTKENPRYDDNEFSQYT-ELAAYINCNQQAA------ATECEKKSYSVE------GQILEE------TK------GENGRIFIEPSSKVNIHLSVHPILPWSEYVIFIGSILGIWLGISIHYNI--PKT-LT------Y------II--TLVV-RL------KRSFELPPFI------VSLWLDR------TuENaC83/1-445 ------MKII------RVK------LS-----SIIDLFCFIGCSI-QIYHV----TCIYLKFKVRHEVTYDYADQVELPTIDIIIPMA------MTINLTELFI------RYPQQMT------RLCKRLFL------DDVSYTNENF------SVCSIA------AKKV------AFLASVDLASFIKVKDIK------ELT------IDPREQIVTIG-SLNS------GEI------TDE------CTMKRYYSG------IAIFLRIVCT------KQD------SL------ITTNTNII------SSYEGNIAAIYHSFGPYFG------IRFTSQLDMPEYELSKY-FMVTQKSPQHVAVAWVRYEKMVSHSLPYPYETNCRYY------DRLKALSNCVLNYTLHS--GGLMRFIINEWHS------QPQHLGFVSLFNHEYEYEYEEEGDEDNNDDEKVDDEK-LKIGVENCVQQSI------ASDCEKTSYLIV------GRISSE------QVP------DPRGLIVIEQPVTPIMYFNANPELQLSEYLIFVGSIIATWFGYSIFDRL--MSP-LT------W------IA--GKFIANI------RKNRESKRP------I------KIFIVRNPYYFTKPIDSA------TuENaC81/1-441 ------M------KIK------LS-----WLVHFLCCIGCSI-QIYYL----TRLYLEYKVRHEVTYDYTDQVALPTIDIVIPMV------MAINLTELFT------RYPEQLN------HFCKVYT------KKVNYTIDNFE-----SVCFHE------VKKI------ATLSSFDLYSFVKVKDIN------ELT------IDPRKQIDYIQ-IGNE------NFT------TDQ------CKLTRYYSG------LAIFLRISCT------EHA------AL------ITDRINNVL------DYYEGKIATIGHSFGPYFG------IRFTNQFDMPVFSLRAY-FMIIQKADK-LTTAWVRYKKMVSCSLPYPYETNCLNY------NKFKAMSDCAVKHSFRK--EFLVDDFVNEWDS------QPEHLGFE------ALKRGEIK------EHCDEM------PIECEKTTYITD------GDISLE------KVN------HTSGLIFIEKPVTPIMYFNVHPEMLLSEYLIFVGGIIGTWFAFSIFDSL--ISI-SI------W------MQ--NKVIAKI------RKGGESESP------T------KLFTIRNSCNFSGTSCRIISHSSRC------ASSHSSIDMLRSIREHNGTN------TuENaC51/1-443 ------M------KIN------LS-----WMVSFLCFIGCSI-QIYDL----TRLYLKYKVRHEMTYDYTDQVELPTIDIIIPMV------MAINLTELFI------RYPEKMI------NFCKIYR------KTANHTIDNFK-----SICFHE------IKKV------ATLSSINFAKFVKVKDIN------ELT------VDPRQQIDYIQ-IGDV------NVP------IDK------CKLERYYSG------IAIFLRISCT------EQA------AL------ITDRINNV------DSYEGNIATIGHSFGPYFG------IRFTSLVDMPIFAHSAY-FMIIQKADK-LTTSWVRYEKIVSRSLPYPYETNCRNY------NKLKALSDCVVKQTIRK--GFLWRGVVNEWGS------QPEHFGFD------VELTTYREAR------KSCAKLP------LLECERTTYIIG------GGINSE------KVN------HTSGLIYIEKPVTPIMYFKAHPELLLSEYLIFLGGIIGTWFAFSILDNL--ISI-LI------W------MK--NKVIAKI------RKSRESKSP------I------KLFTIRNSYNFSDPSLNSISDQSRC------AFSHLSIATVKSTHELTLNN------TuENaC77/1-422 M------QILI------RKK------LS-----WMFYLLCFTGFSI-QIYHL----TCNYLRFKVQHEVTYDYADQVELPTVDIIIPMV------MTINLTELFT------RYPEQMA------NLCKKVNL------DNVDYTIENFN-----SGCAHE------VKKV------AFLASHDLALFIKVKDIN------ELT------IDPREQIDFIQ-IANA------NFT------TDQ------CKMTRYYNG------WAIFLRISCA------EKA------VL------ITDSINIV------SSYEGNIATIGHSFGSYFG------IRFTSQFDIPVFTMSAY-FMIIQKADK-LATVWVRYEKIVSRSLPYPYETNCRFH------QELRVLSDCKVKQSFHK--EYLLKSIVNEWGS------QPDHLGFN------NEPPKVAEIK------GYCFESR------ILDCEKTTYLID------GEVDLE------RVN------HASGLIFIEKPVTPTTYFNVHPELLLSQYLIFVGSIIGTWFAFSIFDNL--NRI-LT------W------IE--SKIVSKT------GKGRGRKSP------I------KLFTIRNSHNLSYPARRSI------TuENaC75/1-419 ------M------KMI------RA-----KLVYLFCIIGLSI-QIYHL----TCNYLKFKVRHEVTYDYADQVELPTIDIIIPMV------VTINLAELFI------RYPEQMT------ELCKMHMN------ERANVTIDNYF-----SECANE------VKKI------ASMASQNLASFIKVKDIN------ELT------VDPRKQIDYIQ-IANA------YVP------AEQ------WKMKRYFNG------WAIFLRISCT------KQA------TL------IANNINIV------RSYEEKIAILGHSFGPYFG------IRFTSQFDMPVSATSAY-FMIIQKADK-KLSAWVRYEKMVSSSLPNPYETKCRHY------NKLKTLSDCKVKKSFHE--RFLMKDIVNEWGS------QPEYFGFV------GDPSKIEEIK------SHCAES------SIECEKTTYTTD------GEINSE------KVK------HTSGQIFIKKPVTPTMYLIVHPESLLSQYLIFVGIIIGTWFGFSVFDRL--IIT-ST------W------IG--SKIITKI------RKGRESTSS------I------KLFTIRNSYIFWNPSLRRTSD------TuENaC78/1-429 ------MKII------QVK------LS-----SIVYFFCFIGCSI-QIYQI----TCVYLEYKVRHEVTYDFADQVELPTVDIIIPMV------MSINLTELFI------RYPEQMK------SLCKEVNL------NNVNYTIENF------SQCSHG------VKKV------TVLASYILAGFINLKDVK------ELT------IDPREQIDYIQ-IGNS------DFT------TDK------CKMTRYFSA------LAVFLRIHCT------EKA------AL------ITENMNII------GSYEGNIATIGHSLGSYFG------IRFTSQVDMPVYELSKY-FMVTSRPNE-LTSTWVRYEKKVSHSLPNPYETNCRYY------NKMKVLHNCVLNYALHK--GILIRSVINEWDS------LPDYMVFD------KHGLINADPLI------YECAQRIP------FPECDKTTYFIN------GEIRSE------LVD------TNLSGLIFIPQPVTPIMYYNVHPDLLLSEYLIFVGSIVGTWFGYSIFDRL--ISM-LT------W------IK--SKVNAKI------RKGRERESS------V------KIFTIRNSDNFSNPLLHSTPYSAAR------TuENaC86/1-457 ------M------RII------LA-KF--SFVNLICTIGCFL-QIYDI----TRRFLQFKVRSDVSYKYSNVIELPAIDLMIPLA------TAINFTKIFN------LKTEMMI------SICKSMVK-----TNSENFTLKQII-----ESCEND------FKNG------PIMSSFALCSFITIEDIE------KSA------DDPRDNILAII-WGQSSQ------DIL------KES------CQLSRYFSG------YAIYVRISCL------QNS------KP------FNMSMDTA------TMSMKIFGALHNTLRSYYG------LRFADPSSLPEPDFTSY-FIIDHKLGE-FPVAAASYTKTITKSLRNPYETECQYY------DKVKSMFECLLNSSLKQKNPFLVPTMVYEWGK------YPSNLGFK------PTTDLDGNYNDEIPDEIL------KHCTQKFY------ANECEKVAYRVE------GKIYPG------KTK------NVFGIILLEPPRTPTMYLKAYPKLQWSEYLIFVGSILGIWFGFSVSDQL--IKS-IQ------Y------IK--SRSK-KM------KQESKFQNE------I------ETVLLSNTIQYWNQLANQKGKQKNDK------ILWASSKYKRDHLRSRY------TuENaC21/1-426 ------METFIES------PNFKR------FH-----SYVKFFCVIGCAA-QLLNA----TGNYLAFKVRNEVSFKYPDCIELPEIDISLPLA------SVLNISRLYE------RYPKQMA------EVCSYLHEDDD-QFDASKITADSYP-----ILCSW------VLKN------ARQSSNRIAEFITVKDIE------ELS------FDARTQIHGLW-IQHD------NDN--NVL------NKY------CSLKRFFSS------NSFHIRISCL------NNS------KP------LQIEAQNL------FASGTSFISVGNMINAKYG------FKLSSFNSNIEPNPIYY-TTIPYREDG-LVFSIIQYRKIVTSLLEYPYETNCIDY------DRDSALADCINNRLLAMKPPSLYHAAVFPFGK------YSGALPFI------NDQSKALPVY------KACYETFR------LPQCQKVEYETK------QEILTD------EVS------QSYSVLVIQASKFPGTIYSSKSHQIFSEYIIFVGSILSMWFGVSIIDRL--TIS------MV--TGIK------IYRQKVTPQTDT------QVNTSPETEPAAE------TuENaC66/1-418 ------M------LL------RR-----HIIRVICIIGCIG-QLYVA----TFNYMSYDVRYGVQIDFPQSYELPNIDLAIPLT------AYLNQTDLFD------RFNSSFQ------SFSDFFNV------STQRLMKN------HYVQSAIIADKIKVKDIE------ELI------LNPENDIFSLA-IKQD------NEV--HIL------KKY------CKINRYFSN------TNIYLRISCR------NNS------QP------IILDVDTI------STDNRILMQLAHTINTLFS------VRLTDINSNMDSRIRSY-TEIPSAVNN-LEVTRLAFKRIYYDALPSPYTTDCEYH------DRHYELHNCVRDKMLNLPNQTLYSAAILSFNT------YPGHLGFQ------QISGEDFNSIY------KYCSRLIS------KISCNLMTYELR------KDYIDG------GVQ------AKFKFLEITPSVDPDIYYTAYPVQVFPEFIIFFMSILSNWFGLSIFEQL--IYG-TS------Y------CK--TCSN------RKAKSANTN------NKNGWQP------IEVATYSIQPTQKIFKPRKLPKH------TuENaC67/1-418 ------M------VL------RR-----HIIRVICIIGCIG-QLYVA----TFNYMSFNVRYGVQIDFPQSYELPNIDLAIPLA------AYLNQTDLFD------RFNSSFQ------SFSDFFNV------STNRLMKS------HYVQSAIIADKIKVKDIE------ELI------LNPENDIFSLA-MKQD------NEV--DIL------RKY------CKIYRYFSS------TNIYLRISCR------NNS------KP------IILNVDTI------SLDNRILMSLAHTINTLFS------VRLTDINSNMDSRIRSY-TAIPSAVNN-LELTRLSFKRIYYDALPSPYTTDCQDY------DRHYELHNCVRDKMLNLPNQTLYSAAILSFNT------YPGHLGFQ------QISGEDFNSIY------EYCSRLIP------KISCHSMTYELR------KDYIDG------GVQ------TKLKFLEITPSIDPDIYYRAYPVQVFPEFIIFFMSILSNWFGLSIFDQL--IYG-TS------Y------CK--TCSN------RKAKSANTN------NKNGWQQ------IEVATYSIQPTQKIFKPRKLPKH------TuENaC68/1-415 ------M------VL------RR-----HIIRVICIIGCIG-QLYVA----TFNYMSFNVRYGVQIDFPQSYELPNIDLAIPLA------AYLNQTGLCD------RFNESFQ------QFADFFNI------SIQRLEKS------HYMQSAIIAKKIKVKDIE------ELI------LNPENDIVTLI-IKQS------NKV--YIL------RKY------CKIDRYFSN------LNIYLRISCR------NNS------KP------IILSTESI------ATDNIVLMSIAHRMNTLYA------VRLADINSNMDSRIRSY-TVVPSAANN-LEVTRLSFKRIYYDALEYPYTTDCQDY------DRNHELNNCIRDQMLNLPNQTLYSAAILSFNT------YPGHLGFQ------RVSDEDFNSIY------GYCSRLIS------KIDCHSMNYELR------KDYIDG------EVQ------TTLKFIDILPSIDPDIYYRAYPV---TEFIIFFISILSNWFGLSIFDQL--IYG-TS------Y------CK--TCSE------RKIESANTN------NRNSSQP------IEEATYSIQPTQQLFRHRQLPKL------TuENaC88/1-441 ------MISVLVSKKLSNL------L----FLFKSNINHGIEYFY--CV------QINTKSAR------MVYKSI------IV-----SMIRILCLFGCLF-QLYKV----TSNFLEFRVRSEVTFDSPKKIEMPAIDFAFPIA------TLINLTALEL------HSPNVLS------NVCQEFKD------NKGGDQQ-----SRCAQ------ALKS------PRIMTQKLVNHLKTGDIE------RFT------RDPTKYFTFLN-IQSQ------FDP--NLI------EKN------CSFKRYFNF------QNIFVRISCL------NGS------NP------IFIDTKNLLV------EDFPFLMMGLTIDGLGSFA------LRLSPVNSQIIGNMNEF-RLINLSSDK-FNILRISFKRKITRMLGPPFETNCRDF------NKKAALEECVNNKTLQY-SHKLFRNIAVPFGR------YSEQIGFS------LVLSDLTKKLH------SECAFKMN------FNECQSIDYSLE------IEKTIE------EQK------YGFCFITLE-PVTPDLIYISLPAQNWLEFIIFVGSVLGMWFGVSMLSQM--MAI-MR------F------CE--TCTH------PTSVHVESSGVS------TuENaC48/1-425 ------MFG------IN------KM-----SWVFIFCFTGCTV-HLGYV----VHHYLEFPVRSQVTIEFPGTMEIPDIDIHLPLV------NALDLNELFN------RYPVELE------SLCKKLGR-----YSSKDDLDKDFR-----SRCLQLFE------TVVMQVYLTDLLTVGDIE------QLT------MNSSSLISNVE-LHREFTD----IPN--GTV------RPS------CKIERHFSG------MGLFLRVACR------NGS------QI------LSKTISTS------SETNQCLLRIGYNMKYSFG------YRFVSHDDVISTRLSKY-KPIYERSDE-IKFTFSRFQRTIANSLQWPYQTNCRNY------HKSRVLQDCLQSKLSNSTEPVIYFDLVYPFGH------YPSHYKFF------RPAKDTKVTQAL------EKCFQLIQ------TQQCYSVWYQTI------STVYVA------RQ------KGQSLICLEPQIEYDVVFTSYPETTFSDLLIYISSILGIWFGISVYGKL--AAD-LD------W------FK-IPVLS------KPLFEKRNI------SIAAITDEMAENNEVKMKN------TuENaC47/1-427 ------MLD------VN------KK-----TCVFIFCFIGCTV-HLGYE----VNHYLEFPVRSQVTIEFPGTMEIPDIDIHLPLI------KVLDLNELFN------RYPVELK------SICKKLGR-----YSSKDDLDKDFR-----SRCLQLFE------TVAMQVYLTDLLTVGDIE------QLT------ANSSSLISNVE-LHREFTD----IPN--GTV------RPS------CKIERHFSG------MGLFLRVACR------NGS------QI------LSKTISTS------SEKNQCLLCIHYKMKYSFG------FRFVSHADVISSRYSKY-QPVHERSGE-RVISISHLQRTIANSLEWPYQTNCRNY------HKSRVLQDCLQSKLSNLTEPVIYSEFVSPFGH------YPSHYKFV------RPTNQINVKQAF------EKCFQLIE------TQQCHSVWYKTI------NSVYVV------KE------DAHSVICLEPQTEYDVVFTSYPEITFSDLLIYSSSILGIWFGISVYGKL--AAD-ID------W------FK-IPVLS------TPLFEKRNI------SIIAIKNEVKIKNEINYNPCE------TuENaC56/1-408 ------MIY------FN------KK-----VLILTFCSAGCSI-QLFQV----LSQFIQFPVRTEIIYDYPSKMIVPDFDIFIRNT------NLLNLTEIYL------KQPKKIT------QICKSFVQ----PSNATIETLEQFN-----DFCSK------AFKS------YEFGLSLGKILTVGDIE------ATN------VEPLIPKVR------VGD--IIR------SDL------CSIERHFNS------INTFLRVSCK------ENS------KP------IEKQLVRNIEADE------RFCIMHNIYNKFG------VRFAHTNSSINPTIVSY-NDIEREKGE-NVLTFLRYREITIESSEWPYQPNCRHY------NKTEIFNECLRKKLFQLYPGTIHMEDVVRAGE------LAKDSKFEDLRT------RLHSPVSQKR------KECAELVK------RPQCVEKTYQTQ------GKTFKE------KG------RGIGMICLESQVDFNIILKTYPKYTLTEILIYISSILGIWFGVSIYGRL------MEG------F------VC--PRID------EPIFQKV------DVAQN------V------KRFPLDIQ------TuENaC57/1-428 ------MIL------LN------RR-----VLTLTFCSIGCFF-HLAHV----VNEFLKFPVRTDIIYDYPKKLVVPEIDIIMYNT------DLLNLTELYL------KHPEKIA------YLCRSRLR----MSNLTIISNGKMN-----ADCVK------IFKS------YFETSLDLAMLLTVGDIE------KLD------VDSLIYKAK------IDD--TIQ------NDL------CTFKKYFSA------PFTYIRVSCR------EDS------KP------IEKRLLPDTEAYD------RFCILHNITHQFG------VRLTHPNSKIDPTINNY-VRIERKKDE-NVFTFLRQREIIIERSEWPYQTNCRHY------QRTETYARCLRDKISQAMPGTIGMLDVVKAGD------FPANCRFNFNIY------SNHSLLSQMR------SECAKQIE------QLQCIEKTYRTQ------GETFKE------KG------SGLGLICLANQIDFNIILKTYPQSTFTELLIYISSILGIWFGISIYGQL------MDG------F------IR--PSIP------QPTVKKV------NVLPNTLTKRTNI------QVGPNL------KTSAIIEQSYLNGQ------TuENaC58/1-410 ------MMNK------HCSAS------HR-----QLELIFCSIGCSI-HLFTV----VNEFLKFPVRTDIIYDYPEKMIVPEIDIILHNI------DLLNMTALHL------KYPNKMT------QICEHFVK----ISNFEMNSI------EDCIK------FLKS------YYERSYHVGKMLTVDDVE------KLD------VDSLILNFV------AKEVD--FVR------NDL------CSVERYFNA------VNTFLRVSCR------EDS------KQ------IERRLVRNIVIDD------GFCVKHNIYHSFG------VRFAHPNSSIDAHVLNY-LPLERGEGE-NLFTMLHYREITVESKEWPYQTNCRHY------QKSQIFSKCLREKISHSYPGIVQLEDVIQVGQ------YPSDFKFDDLKY------DVNETISQIK------SGCAELVK------QPQCIEKTYQTQ------GRSARE------KG------SGIGLICVGNLIDFNINLKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------IF--PTIP------QHSTQKV------DVVPN------V------ESTSIHD------TuENaC59/1-413 ------MIF------LN------RK-----VFILTFCLIGCSI-HLFTV----VNEFLKFPVRTDIIYDYPEKMIVPEIDIILYNI------DLLNMTALYL------KYPEKME------NACEFLMK----SANLENNSS------ADCIK------FLRS------YYEKSYHVANMLTVGDVE------RLN------VESLIIESE------SAFAD--FIR------NDL------CAVKKYFSA------MNTFIRVSCR------EDS------KP------IEKRLMRNIATDN------HFCIQHHIYNRFG------VRFAHQNSSIDSYVFNY-LEVEREAGE-NVFTILRYKETTIESREWPYQTNCRHY------KKENKFSQCLREKISHLYPGVVEFEDVIQVGQ------FPSHFKFEDLKT------RTNETLSLIQ------SECTKLVK------QPQCIEKTYRTR------GRSLKE------KG------SGIGLICLDNLIDFNIILKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------VF--PTIT------TQMSGAITS------KVGPG------V------EISTMTEEHETV------TuENaC62/1-412 ------MIF------LN------RK-----VFILTFCLIGCTI-HLFHV----VNEFLKFPVQTDIIYDYPEKMIVPEIDIILYNI------DLLNMTALYL------KYPEKME------NACEFLMK----SANLENNSS------VDCIK------FLKS------YYERSYHVGNMLTVGDVE------QLN------TESLIVN-K------SNVAD--FIR------NDL------CTAKKYFSA------MNTFIRVSCR------EDS------KA------IERTLVRNIMPGN------RFCIQHNIYHLFG------VRFAHQNSSIDSYVFNY-LEVEREAGE-SLFTFLRYRETTIESSEWPYQTNCRHY------KKEDIFSQCLREKISHAYPGVVEFEDVIQVGQ------FPSHFKFEDLKT------RTNETLSLIQ------SECTELVK------QPQCIEKTYQTR------GRSLKE------KG------SGIGLICLDNLIDFNIILKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------VF--PTIA------TQMSGAITS------KVGPG------V------EISTMTEEHETV------TuENaC63/1-410 ------MML------FK------RK-----VFISAVCSVGCSI-HLFTV----VNEFLKFPVQADIIYDYPEKMIVPEIDIILHNI------DLLNMTALYL------KYSNKFD------HLCEYLMK----LSNLTINSR------KDCLK------YLKS------YYESSYHVGNMLTIGDVE------QLN------VESLILNSK------SKTVA--FTR------NDL------CSTKRYFNA------VKTFIRISCR------VNS------KP------IERRLVRNIMADS------SFCIQHNIYHLFG------VRFAHTNSSIDPNSLNY-EAVEREAGE-NVFTILRYKETVIENSEWPYQTNCRHY------QKENIFIQCLREKISHSYPGIVQFDDVIQVGQ------FPSNYKFEDLQS------RANETLSQIR------IECAELVK------QLQCIEKTHKTQ------GRSSRE------KG------SGIGLICLDNQVDFNIIHKTYPKSTFTELLIYISSILGIWFGISIYGKL------MDG------F------VF--PAIS------TQMSESITS------KVGPS------V------DTSTMTEEQ------TuENaC60/1-439 MVKNTIEFIKLTFRLQLLLEFAWSEISFQIAVS-MIF------LD------RR-----VLILTFCSFGCSI-HLFTV----VNEFLKFPVRTDIIYDYPEKMIVPEVDIILNNI------DLLNLTELYL------KQSEKMT------HLCEYLMQ----KSNLTFNLDENFN-----SNCTK------ILKS------YHENGHFVGNMLTVGDVE------NLK------IDSLIFKYK------ST--SNR------DKL------CSIKRYFNA------VKTFIRVSCR------EGS------KP------IERTLVRNIVADN------RFCIKHNIYHHFE------VRFAHINSSINPEISDY-IEVAREARE-NIFTFLRYREIAVENSEWPYQTNCRHY------RKSQIFRQCLREKISHSYPGIIHFDDVLEVGQ------FPSDFKFDDLQS------RENETLSQIR------RECTELVK------QSQCIEKTYQTQ------GRTCKE------GG------TGKGLICLENQVEFNIILKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------IL--PTIS------HRPTPKV------NVIPN------V------ETTDNQ------TuENaC61/1-414 ------MVTIS-MIF------LN------RR-----VFILTFCLIGCTI-HLAHV----VNEFLKFPVQTDIIYHYPEKMIVPEIDIILYNI------DLLNMTTLYL------KQPQKMT------LLCEHLMQ----KSNSTINSDENFD-----ANCIK------LLKS------DAENNHFVSRLLTVGDVE------NLN------INSLIFKYK------SS--SKR------DDL------CTIKRYFNA------VKTYLRVSCR------EDS------KP------IERTLVRNIVADD------RFCIQHNIYHRFG------VRFTHPNSSVNTEYLNY-IEVEREAGE-NIFTFLRYREIVIINSEWPYQTNCRHY------QKEKIFNQCLREKISSSYQGTVQLRDVLEVGQ------LPSNLKFADQQS------RDNEASTQIR------RECTEQVK------QFQCIVKMYQTK------GKTYKE------KG------SGVGLICLENQIDFNIILKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------IL--PTIP------QRSIHSV------NVMSS------V------ERTENQDMT------TuENaC64/1-396 ------MI------LN------RR-----VLILTFCSIGCSI-HLFTV----INEFLKFPVRTDIIYDYPEKMIVPEIDIILYNI------DLLNLTELYL------KHPEKMA------DICR--LK----FSNLTIISNGEFN-----SDCTK------FLKS------YHESGFFIAKILTVGDLE------SVN------IESLIFEYK------ISG--FIR------NDL------CSIKRYFNA------INTFIRVSCR------EDS------KP------IERRLVQNIVADD------RFCIMHSIYHHFG------VRLAHTNSSINPDEINY-MAVDREAGE-NVFTRLRYRETVIENSEWPYQTNCRHY------QKSKIFSQCLREKIFNSYPGMVQLEDVLHVGQ------FPADFKFEDFLS------VNETLQKVR------NECAEQVK------QLQCIVETYQTQ------GRTYKE------KG------SDLGLICLENQIDFNVILKTYPKSTFTELLIYISSILGIWFGISIYGKL------IDG------F------IF--PAIP------QRSAH------IYPF------I------YM------TuENaC55/1-437 ------MTE------KIARFLN------GK-----SLIWFICFSGCSY-QLFNL----TYRFISWESRTDTIHRYPEVVLIPEIDFYFPLG------TLLHMNAVYK------RYPDEIA------SLCMKLFG----TKNVTINSVSDFD-----EHCSA------LKEA------IFSSDVFLSKVLTIGDIE------ELT------EDPRPFIKAIY-SLDT------KQN--YLE------TKV------CNMSRHLNA------GGIFMRITCR------NDS------KP------LSYAFSHG------SGGNNFLIYLEHTIDTPFG------FRFSNHDDPISHHTAKY-EFMKKSTDV-HYTIITYFHRQVESVQDL---LGCSNY------NRMNVLFECLNSTVQSS-SPFVFYDAIISFGT------LPRNTKFIDPYD------EPTGQFFNLF------KSCTELIV------KPRCDDVDYYTT------FQVFHD------QVLV------QSPRQILIDTPNAPDRILVTSLKMTLDSLMYSCYSILGIWFGFSVCDKW--TQWNAES-NCGW---CF------CC--CCLS-KL------RKRKKSGSR------KRAPVS------QLKIIREIETDSS------TuENaC85/1-432 ------M------KFKFLK------GR-----PKIWICCFILCAL-QSYDL----IKNFIEFDVRSEIIYNFSEPIEVPDMDFFFPIV------TLLNFSAFYH------RRPTELV------YWCKTLFN----KPNVTINSVQEFD-----QHCSN------LSLL------ITQSSTWLPALLTVGDVE------ELT------QDPREVIDGIT-NMEGT------PYE--MFS------RKI------CTKKRFLCG------FGVFVRISCR------NGS------LP------LTSEK-GG------LGGNNYILTIQHRIDQTFG------FRFASHKRNIKSKASEY-LFIEPSKDH-FYSVFAYFNRQVTTSLPWPYKTKCINY------NKDKTMAECLNSHLLNLSKPTISLDSVIPFKY------YPRNTRFTNGFL------ESSGLFMEFL------GQCTKLVE------KPECREVAYHTN------AKIYVD------SAPA------AGS------STMSTMIVDKPIDPDLHVIAHEKWTFVEFLVSLYSILAIYFGVNVFFKL--KQR-LT------T------LN--KCFD------KSHNDQ------KNGPKKRA------F------I------IVDPNRTFPLYY------TuENaC52/1-430 ------M------LNIKFLK------NK-----SKIWILCFILCAY-QSIYS----IHNFIQFDVRSEIIYNFSQPLEVPDIDFFFSMV------TVFNFSAFYH------RRPTELV------HWCKILFN----KPNVTINSVQEFD-----QHCSN------LSLL------ITQSSTWLPALLTVGDVE------ELT------QDPRELIDEIY-SFNDI------RKN--LFD------TKI------CTKKRFLNG------YGLFVRISCR------NGS------LP------FTRENTSG------LGGNNFILGIKNRIKFPYT------FRFASGNRSIGNQGSQY-IFIEPPKNK-YYTVITYFTRQVTTSLPWPYKTKCLHY------DKDKTITDCLNSHLLNLSDPAISIDSVVPFKH------YPKNTRFTNGYL------DSSGVFVNLL------NKCNKLAE------NPECREVVYRTS------FKIYTD------EAPA------VASCMMLVDVPTDPDVNFIAHEKWTLTELLVALYSVLAVYFGVNVYDKL--KSR-LE------G------LN--KCFK------KSCNQQ------QIVPKERV------F------I------IVRPNRHVPSY------TuENaC53/1-430 ------M------KFKFLK------DR-----PKIWICCFILCAF-QSYDL----IKNFIEFDVRSEIIYNFSQPLEVPDIDFFFPIA------TLLNFSAYYQ------RRPTELV------YLCKILFN----KPNVTINSVQEFD-----QHCSN------LSLL------VTQSTSWLPAMLTVGDVE------ELT------QDPRELIDEIY-SFNDI------RKN--LFE------TKV------CTKNRFFNG------VGVYVRISCR------NGS------LP------LTRENTSG------LGGNNFILGIKNRIQKPFL------FRFASGERIIATQASRY-VFVNPPNNK-YYTIISYFSRQVTTSLPWPYKTKCLHY------DKDKSLNQCMNKHLLNLSNPTLSLDAVIQFNQ------HPKNTRFTNGLL------DSTGAFMNFL------NQCSKLID------KPECYEVIYHTS------AKIYID------QESS------GSSSTFAVDVPIEPDVNFIAHEKLTLIELLVASYSVLGVYFGVTVYDKL--KLR-LQ------D------VN--KCFT------KSDNGQ------KLGPKKRA------F------I------IVGPNREVPLYY------TuENaC54/1-433 ------MQKL------LNIKFLK------SK-----SKIWICCFILCAC-QSIDL----INNFIQFDVRTEIIYNFSQPLEVPDVDFFFPMV------TVLNFSAFYH------RRPTELV------HWCKILFN----KSNVTINSVQEFD-----QHCSN------LSLL------IGQSSTWLPALLTVGDVE------ELT------QDPRELIDEIY-TFNSI------RKN--LFD------TKI------CTKKRFLNG------YGLLVRISCR------NGS------LP------FTRENTSG------LGGNNFILSIKNRIKRPFG------FRLSSSKR-IVNQGSQY-ISIDPPIDK-YYTVTSYFTRQVTTSLPWPYKTKCLHY------DKDKTMTDCLNSHLLNQSNQAITIDSVAPFKF------YPKKARFTNGLL------DSTGAFMSFL------NQCSKLID------KSECYEVNYYTS------AKIYID------QEYS------KSSCMFQVDIPINPDVYFIAQEKLTLTELLVSLYSVLGVYFGVTVYDKL--KLR-LQ------D------VN--KCFT------KSDNEQ------KLGPKKRA------F------I------IVGPNREVPLYY------TuENaC105/1-434 ------MV------RLN------VN-----LCALIVCSIGCFH-QLSTI----IEEYFQFRVRVEVTYSYPKMIEIPDIDMYFPFP------PLLNFTGLYL------RYPERMI------FACKTVNN----VENVTIRNVDDFN-----EYCST------LSDH------TFQVYEHLTTLLTVGDIE------ELT------VDPTTFIESVT-LIGN------NDN--LLH------KNI------CKVERFLSG------MGIFMRISCQ------NNS------RP------LAQDSLLS------QSGNFALLTITHNINMMFG------FRFSHHHDPIDSQVGQY-HSVAATKGQ-FYGIVAHYSRRITTKLPWPSVTDCVDY------NRAKVYAECLDNLLLLSERKSVFVDSVVAFGR------YPKKSTFASFFT------ETLIHNSSTIVGFV------DFCKALTS------KDDCNKVHYISY------YEVYTE------KTS------QRPYVIEIAPQIMPDLWLVGHEKLDLPGFLYSVYSILGIWFGINVYDKF--IGR-YE------W------LQ--NYLK------AKKQNAKLI------EIKPMPRT------KVIQIRTIQPTAIYF------TuENaC01/1-492 ------M------CFN-IIQRFKLY------DK-----ELIFVICFIGAAI-QMLDL----FQRFFAYEYLTKAFVGVPEATLLPDVSICFAII------DMINYTKLFS------NYPFLLQ------DIGFPRGTSI------TADIVKSIR------GEYS------ENDLLLFFMERLKINQIW------TQM------ISSKSVFMKAV-TYRV------DEL--DII------EES------CPFKEFFIE------QAYCYSFSCSDV------QSK------QS------HLYGLIEQYK------RLNNRQIFTLSLHQPFFNTINYY------WIGLTAVGTLPRGQQVKW-EAQAAYKN--TKRHTFFFSSIETRLLPAPYKTNCVNYT------EKGFL------TNTEMADACEIDLSMKQ-IGSPLPENLIG------SPLDAHFGVPVY------EHNRANSSFLQLVSDIV------DHCSKITK------QPNCLSVVYIPS------SRTPLP------IM------SNYTEVTVEQVSDPIYIVELESRLTKLDVIIAIGSILGTWLGFSIVYSI--PQL-TG------F------LG--IKFL-RLKG------TRAGNMKQK------RNSTLGSD------VFSTSYLNKARLYGIESWNDD------YKQNKIRHFP------SFYVYY------NQQAWPMTYLEKHHHWWLRR TuENaC03/1-487 ------M------KPKNVI------VFKVTNFFSTLT------DK-----QVILIVCFIGASI-QTIYI----LNRFLEYDTLIQAHVGVPDATTIPDFNLCFDLL------DVLNFTSLST------SYPFIVQ------ELGYKPGTPI------TNGLIRSLR------REK------GNDFIFFSIGQFKINQLW------QHV------VSPSSVYTKAF-AQKV------SSD--GVI------EEP------CSSTRFFIE------QALCYSFSCSDGS------NSS------IVTGLNDLYK------KLNKQEIFTILIDQSFFSSIGYY------WVALTSRGKLPFGTNLKW-ESQQGFNV--TRKHTFFFYTVEIHRLPLPYNSKCFDYS------VKGFS------SREEMNDQCKINLSLQY-FGGPLPLNIIE------SPIDAPLGYIMF------EKNRENASFLAIVSDIV------DHCDHLTA------QLDCFEIIYSPS------SRTPLP------IW------SEHTEITIEQISDPVYIIRVEPKLTVLDVVISIGSILGSWLGFSIADSI--PQV-TS------F------MG--THVF-KFTN------KKKGRDFQI------QSHSNDDSHIFMLPSSES------IK------YQNYRAYLQRY------YFHRYPFNY---HQQGWPFT-KVKARLY---- TuENaC04/1-484 ------M------GFSLVFHFFGLN------HK-----QIFLIICMIGATV-QISYL----LYRFFSYELLTTCHVGDPESTLLPDIAICFPIL------DAINYTALFL------NYPSILG------ELGYRPGTRV------TYELIHSIR------AKVS------DNYLLFFFQERLKIDQLW------KQI------VNSSMIYRKAF-VHKA------TDD--DII------RLP------CSSNDFFME------KEYCYSFTCSSAY------NSS------EP------IVTEKVDLYK------KLTTQEVFTLEVPQSFFRTIDFY------WVSLIPRGELPRGNKIKW-ESQEAYDI--ARKHTFFFYYIEIRRLGPPYPTNCANYS------DRGYL------SRVDMEDKCEINLSLQK-IGSPLPTSIVD------KPLDAPFGSYIL------EKNIQNETYLDSISKIA------EACLQIAS------QPDCYEINYFPL------SRTPLP------IQ------GNYTEITVEQVSDPIYTISIEPKMTLLDLIISIGSVLGTWLGFSIVDSI--PQV-AS------F------IG--VKFF-NLPL------RKDDQYRDN------SSSKLSVPSAYLVRPKSHS------KKKDIQKRAP------PFYTYYD-----DKNEWPLFYNVRARPWWPR- TuENaC02/1-523 ------MLSRINK------SHFEKLQLLLQ------LIVKVVPNNMV------STLIKSLISGSN------EK-----EIVLLICVIGASV-QIINV----LNRYFSYEYLIQAHVGVPQSTLLPDVAVCFDIT------DMINYTRLFS------TYPSVLS------ELGYKPETVI------TEQLIETVR------N------EPNFLVFLFEHLKINQLW------DQM------INKSTVYSKAV-FHQV------TDD--SVV------LRS------CSSRDFFSE------QTYCYAFTCSMPGKGV------NSS------LP------VTTETSDLYK------KLTKQEVFTLFVYQSFFTTIGYY------YMSLMPRNQLPRGEKMQW-QSQEAYSV--PRKHTFFFYTITTNFLRSPFPTNCIDYK------DKGYL------SNSEMKDKCQINLGLQR-IGTPLVSNILD------YPIDSHFGYENF------ENHKDNETFINIVSEIV------DYCERITL------QPDCVEEINILT------SRTPLP------IF------GDYTEITVEQISDPVYVITYVPKMTPLDVIISIGSVLGTWLGFSIAYSI--PQL-TT------I------LG--IKCF-KLLP------LRRQDHLQPTLLNQQIYHHKAT------PMTKISPESRLKSGSNDRS------RRKMIHKNE------PFYVYY------NQQAWPLLYDIRTRPWWYR- TuENaC05/1-487 ------MLHKSNP------WKRLK------SH-----QLFQIFCVFGAII-QVSYI----FKRYFSFAYSTRAIIYVPDRTELPDVIICYDML------YMVNQSKLIT------VYPNLFQ------QSKLNHSEVL------EVLKNSYNGYFTNLTIKQTW------NLM------LSSEAAVHSAI-ARSA------PDK-GKTI------TYD------CPFRNVFYR------NAYCFVFTCWTE------RP------AIIWSRNLYR------GSQYETFFEINFHQSFFQKIHYY------YLALINPKTTALGASLKW-ESQETVAQ--TQSHRYFFYSLQVDYLPKPYATNCLNYS------ELGYP------SRIDMINQCEIKLAMEL-LGAPLAWSIID------YPYDKLFGKQIY------DQRKEDPGYLKTVEEIV------FRCFDAAK------QPDCVARSFYSS------IRSPIP------IT------GNFAKISFDTIRDPIYRITYEPEMTILDALIMTGTALGTWLGFSIAVHI--PRF-FD------SIIC-----N------CKNRKQSAGLPN------YSYTRKSKLSRISPNHDR------VFTLLSHSNRKESF---DSQLKPGFRFPFYL-YYELPNYDVKPISIRSPKSPKKS------QKVDTFY------TuENaC07/1-467 ------MPTRRRL------SRVFKFTIFGFG------LH-----TIFTIICSIGFLI-QLILV----LINYFSYPVLTNVYLTVPEVTELPDVPVCFDGA------YMINWTKALL------EHPQFKTVF-----KIPRSVNTR------DEAAIR------VHIFKLFD------KNQIMRLTVKNLTVRQTG------NLF------YTKDELFDSVS-ITNLTA------SES------KDY------CEIHALTRK------MRYCSVIACSVK------KV------VTLSNLENAK------SSISPNILTIRIKQQIFDYAPNF------FITLVPPKIMPRGNLLRW-DTMSVYHKE-PRFYKMHYFIFERRLLPAPYATNCFDYH------TLGYK------QSIDMKDSCFNNESMKM-FGVPFHASTLN------LSIGIPFGSVKY------AENQFNTTFRKQLDTIV------DTCFKLTE------RPDCYRKTFIIR------PRNPII------TT------GNCSVIAFGSIKEPNIKVVLEPRLVWVDIIITIGSISGTWFGFSIADHV--PLI-YR------S------SW--NKVS------SWIRFQPKAEK------TKTRVIRELQRRASKRLPS------IYEHYHS------PLGYRNYPRF----- TuENaC28/1-510 ------MEELVET------K------SRDHCVDRVTNI------LN-----DVFKCLCVLGFMI-QLSYV----LFRYAAFEYLTFTIFNVPDETKLPDFFFCSDFI------SFLNFTLLFQ------RYPQLLT------AFGLSRVP------LSTPQQSIK------DQLLTRSS------VRNVSIAITQYLSLRQVT------ECL------YTTDELFGGLN-IRHALN------KKI------TDL------CDFRLFYRA------FMVCFVFVCSLD------GP------IITTTNDFYK------DPVPPELFLLEFRQSFFRSVDYV------FIGATLPTTLPVSPSCKM-DVQTMTDY--PRAFRYHLKTVQLNLLPPPYLTNCRNYARIKT------DNNYT------SRDGVLDECLTRKTVQI-TGCPHPLSLQS------SHWDLPFAAECY------ERNYNNITYRKLINSIV------DECFRLNS------QPDCSRTAYFIQ------GRAPVA------IF------GDFGTFVLDSIVEPIISVDYEPKMTWLDCLVQIGSCLATWFGFSILIHI--PKI-SR------F------LV--HKLH------FCVTCCEPSDQVLPKRKSIINS------ASHSLSMFPTSPGKKLFKPAEHP------IRYISPTQSMIR--RRSLLFNPNNRI------IQTKKSATNSNKRQTRK------TuENaC06/1-461 ------MKNYQNR-----LKSS-KFL------FNQKNKLSSSPRPTKSTST------RHFK------LLS-----STFKILCFIGFSA-QLLTI----LQRYLQFDMRTRVNVHVPMITSLPSFTLCFETV------NLVNYTKLFE------LHPELKR------VLFDEDDI----ESMLTLEQRQTQL------TRLINRFG------HRGLFLQLAANLTISQIT------ETL------VQPEQLFQSID-LLDQLN------QPI------EKH------CQIFNFYRY------FRYCYTFSCKL------NNN------LS------VSKSKDGIYT------EPITYGLLFLYMKHNFLSQLEYF------YLTFTHLDTIPHGILSKW-ITQSIDAHK-VQQFRYNFVLLTLNLLPSPYASDCATYK------DSRGQMV------NRESILDQCFQNKSLSL-LNTHFAKSTIP------AYSSYRFPFRVY------YENRDNITFIERVEDII------DFCYDRYS------QFDCQHYYYAIQ------DRDPIT------VA------GNLSVIFIDEIIEPTFTLTLYPRMTLLDCLVQMGACLGTWFGFSIYYDV--PTI-FT------F------VH--LILT-KL------RVLCPKSSALNR------TuENaC08/1-431 ------MKLNLTK------DKLFK------LE-----NFVFLFCGFWCLF-QIYFC----TVKYLSFDFVTRINWFVPEKTPLPDLVLCFDFV------SLINTSKLFK------NYPEVVK------KLGIKNEDE------FAQLKRTS------TAKIGTQLIPLLTIREIT------SIL------YTKDKLIDEIV-VLNQTS-----RDD------AKL------CQNIGFFTS------NTYCAKITCSYR------HP------ISANVSYVDH------LSENVPFFYVTVNTQYLTNESIY------FVTLVKPNTFPWDHGMAW-LSFDNYRG--PSIYMISFTMYLEQKLPAPYQTQCYDYK------VDGYI------EQSQALNECLNRSFSNV-LNSSFHHAIVR------DNLDRHIDLKIF------DPAFKYTLDKIV------DKCVQRNS------RPDCNNLNYPIV------GYSRLN------RRPR------QNRTLIGLELIKEPVLLVYVEPYMTLSDLCIVIGSILGSWFGFSINYHV--PLV-CS------T------FY--GKCMRYLT------ERSRQQRSS------PPSHD------IRVHSG------RSKPTK------TuENaC134/1-506 ------MNLSYKS------MRNFSPAKFIT------LR-----NCFFILCLIGCFL-QVRKL----VRIYENFDHITRVTIETRTETIVPDFSMCFEPM------SLIDPDKLFK------HQPEFAA------SIGVHDTE------SWLKM------LQTN------GSTLNYLLTGNLTIKQIT------DLL------YETGRFIESVE-LSAGGR------KPV------LDL------CKVKRFYNA------GHTCILLQFNHS------KSQEL------DP------HFE------LKNNKNFLARISVQQGIAKHIPRA------FSTLVEPDTLPWDHKATW-VNLPLQQE--PSRIPIDFRTMKNEYLPHPYRAQCITYS------NLGYK------SQAAARSECLNRLSTKL-LGNPFHSAIYE------ANLDMYIGSSAF------EKNQANKTYVNIIGQIV------VECYKKYN------RKDCIKTAILIE------VKPPIH------A------KENSTIQLEFPKGPNIFIRQEPASTLTELMISVASITTSWFGISLTVQI--QKI-VS------T------AA--ALTN-AI------RKKKKLVNE------SKVEYFDEQNNKKSLAPKRLVSNRKMFERRDYTNRLYILAYQGLIHESQAAESF---GKFNHP-----FHYLEQDVTRKMKRRESLKNQQDFTNH------TuENaC09/1-472 ------MNFLTKF------EKLLT------IY-----TLVQIICSIGCFI-QIEYV----FKRYFGREITTITTVEIPDETILPDIVIRVEVL------SFINYTLFFQ------RFPPVGA------LAFFKYNT------TRELR------FSLRNVTF------TKSISQLIEKELTIKETT------SLL------YKSKDFIKTIY-VRSIETM----KDG--SFN-----SDYVDR------CQFKEYFQS------SFFYIVIACSTK------GP------IIGSFILKDL------NPGVADFFALVLTQRIAMTQQGI------RIAFIEPNSSPSNRRVQW-TRLPLRDG--NSVYATSFQLITLTLLPAPY-SNCVNYT------NEGYE------NRYEKLDECLNKLSQKW-FNRLFYQSLHR------ADIDAPFVGFDQ------DLKFENATFAKLSNDIV------TRCEAETM------GMDCYERHYNVK------EPDAVR------SM------HPLTAIILSISKRPYIDMITKPKFNFIDCLVSIGSIFGFWFGFALNTHI--PWI-TC------L------IK--SKLM-PIRN------GKLTNTNEY------PSRNG------PIRKIKLTQLNEELSNNYYTLRP------RESNRLSIKNSRRLTVT------TuENaC10/1-472 ------MNLLTKC------KELLT------IY-----TLVQIICSIGCFM-QIEYV----FTRYFAREITIVTTVEIPDETILPDFVIRVEVL------RFINYTLFFK------RFPHVGT------LASFKYNN------IHELK------TSLKNLTL------TKRISQLIEKELTIKEMT------SLL------YKPKDFIKTIY-VRSIETM----KAG--SFN-----SDYVDR------CQFKQYYQS------SFFYIVIACSTE------GP------IIGSFILKDL------NPGIADFFAVVLTQAIAFTQEGI------QIAFIESNSPPNSQKIQW-TRLPLHDG--NAVYTTSFKLITLSFLPAPY-SSCVNYS------DEGYD------NRFEKLDECLNKLSQKW-FNRPFHQSLHR------ADIDEPFVGFDQ------DLKFENETFAKLSNDIL------TKCEAATM------GLDCYERHYNVK------EPDAVR------SL------FPLTAIILGISNQPYIEMVAKPKLNVLDCIVSVGSIFGFWFGFALNVHV--PWI-TC------L------IK--SKLM-PIRN------KKLTKINKY------PPRDG------PIHKIKLAQLNVELNNNYFTLRP------RESNRLTIKNSKRFTIN------TuENaC135/1-461 ------MKS------DIFKCLN------IQ-----NIFSLVCVLGCSV-QINYI----FTRYFKSEIISIVTIEIPDKTTLPDISFCFEKL------KSINFTKLKA------FHPNIKLPDNLP--EIIANLPSRR------DD------TKTQ------HHTISDILAKHLTINETT------NLL------FEPDQIFHRIR-ILPH------RSN-SSEF------KDY------CRFNKFYYQ------KCSSD------IQVHVEEVNL------YPDYIFLMQIMLDHKFSKRFRRI------RVSFVERGGVPASRQLKW-LPIRTEKT--PTVHLLNFFSVKTKMLPFP-GYSCVNYN------ETAFE------TRDAKLVGCFNRLSLEK-FGQIFHSSPVL------ADSNLRFA------TSDQLFDPNYRKTVDQIL------SRCEKEAI------LYDCSSERYIIR------TRVPVK------SP------NQFTHILLEPTKSPNIETRAQRAVTFLDCVIAVGGVFNFWFSFAINVHI--PKG-IR------L------VH--KKCK-SLT------DKPENHFKK------DNHFQCYTQKLIVHTDKP------FKVYTIDKTWS-----GPTVDLKP------LKAKISNLPEK------FISTYH------TuENaC116/1-522 ------MMKFNKN------LFRLIKSRLTSLII------CK-----SIFSLFCLLGCLF-QLVHL----TRIYLKFEVITEIVISLPQRLVLPDICMCIEIV------QFVNLTKLNE------LYPALAQ------QMIKYDRS----ENNATVTDIYGVN------ASVINHYVLYNLRINETY------NLL------YPDSHLINSWE-IGSRSIV----NQS--VLE------SQG------CRMRGRFKD------FGYCITIGCP------QSNH------QAFGEFDYLR------SQIGRPMFAIYLNRQAINHIPNM------YVALIKNTALPRGNTIKF-ETLKLNA---SRKYPISYHIFRSNLLPPPYSTQCEDYA------SDRFD------TMEHARELCLTNATLKR-YNIPFPKVLASPDW------G-YYNGYRLM------FDAITNQTLQTELDSIV------LGCINITY------QPHCHDTYYITT------TTDSEY------IS------SSNSQVELRKPVEPYITTTCQPKQSLPEFFIYAGSVLGTWFGFNFAYSI--PSL-ID------L------CY--HKIYKKIAP------QRSGSSSRSHSGSP--FYLDPGYNLD------SSKRFDGHKKWAKSINPNSKG------YYGSPGSTKI------RLRHQP------GKESFSHGNAKQQID------LWPGFYDCYLLRKYRPKSLGC------TuENaC20/1-486 ------MDDLNQV------TP------SPLSSPPALRKR------IR-----LLIHLLITTLSAV-QIYSI----TIDYLYGEITNKVNLRYPDKFILPDVSLCFPFL------DLINLTKADQ------QFGNFSS------ILRNRPFF------EDYSSHND------VYTEIYSLLGNLTAKELN------GLL------KDIKHAVPVVK-LAPTR------RPN--DISIGPQLVNADSS------CEITHFIRQ------PSFCLTIRCL------NETK------QP------LEYKREHIFQ------RPYNGVMLKIQLNPNVSIMASTV------NVLFTSHSHLTQGKKQSA-FRIGFNES--PATHIITYSKIINLLIQDDYEISCFNYS------LIGYL------SRDDYLEACLNNASSQA-TGAVFYGTVQNFNDTSDH------MSDFHQFYHEYL------NPNETEREKKRQFYKFCR------EYCARQAD------KPDCHQEILYPV------AFRKIL------RS------DGIYEVLVRAPTSPFEINRYFPEYTLLDLLIYFASSLNFWFGLSLVSLS--ERF-LN------F------YC--NLFK------RKKESKSQK------NNLPIKLSKPKVASSKPME------VFVVQ------TRRP------RVTKIKDISNELPTVYY------TuENaC22/1-485 ------MDDL-KC------TP------SPLSSPPALRKR------IR-----LLIHLLITTLSAG-QIYSI----AIDYLYGEITNKVNLMYPEKFILPDVSLCFPFL------DLINLTKADQ------QYGNFSS------ILKNRPFF------EDYSSHND------VYTEIYSLLGNLTTKQLN------GLL------KDIKHAAPLVE-LAPNR------RPD--NLQIGPKLINADSY------CEIFHFIRQ------PSFCLTIKCL------NETK------QP------LEYKREHIFQ------QPYNGVMLKIQLNPNVSIMASTV------NVIFTSHSHLTQGKKQSA-FRIGFRES--PATHIITYSKIINVLVQEDYEMSCFNYS------LIGYL------SRDDYLDACLNNASSQA-TGAVFYGTVQNFNDTSDH------MSDFHQFYHEYL------NPNETEREKRRQFYKFCR------EYCAKQAD------KPDCHQEILYPV------GFRKII------RS------DGVYEVVVRAPASPFEINRYFPEYTLLDLLIYFASSLNFWFGLSLVSLS--ERF-LN------F------YC--NLFK------RKKESKSQK------SNSTIKLHKAKVTSSKPVE------VFVVQ------TRRP------RVTKIKDISNELPTVYY------TuENaC11/1-481 ------MDNLNQV------TLSSSPALRKR------IG-----FLVHLLITAICTV-QIYSI----AIDYLYGEITTKVNLTTPKTFTLPNVSLCFPFL------GLINLTIADQ------HFQNFSA------ILKNRPFF------DDYDTHRD------TYTEIYSLLATLTTSQLK------GLL------KDIGRVTPMIK-LTPIY------RTN--DSITGQRRVDVKSS------CEITRYFRQ------PSFCLTIRCF------NETK------QP------LEYVRADILQ------QPHNGDMMRIKLSPNVTMMAPSV------DIVFTAANHLTHGKKQSA-YRIGFTKEN-PATYVITYTKIINILIQDDYEISCFNYS------LIGYL------SRDDYFDRCLNNASSTT-TGTAFYGTVQHFKDTRVL------MSGFRQFYDEYL------NPNEAEREKKRKFYKYCR------KYCSHQAN------RPDCYQEIFNPI------GFRTIH------RS------DGIYEIVVRAPATPFELNQYYPEYTLLDLLIYFASSLNFWFGLSLISLS--EQL-LN------F------YC--NLFV------REKKPKNNS------TIKLSKAKVVSSKPIE------VLVAQ------PRRP------RVTKLKDIPNEIPIVYY------TuENaC12/1-481 ------MSILGRI------GSIYR------HRRLI------LS-----MTIRTMMAFFCAY-QLRSI----TETYIRGETISKVNLSFPEFLTLPSVTLCFDFI------DTLNVTRLSG------DYPYILK------TLQSRDLI------DDYVTRHS------HLPELYYLLGNHSLASMK------GYM------NDNIDFLLAKIT------PTQLEPD--DGL------KVN------CNVTRYLIE------PNFCHTITCYHV------DSD------EP------AKYPRSTIFE------PRYGGRMLIIELESWVGNLTKSM------SIHFTVQSSLLYSTRTSS-YLIDLTHP--PTTFTVSYSMIRNDLDSIASETKCLPSGSF------REGTG------NRNQRFYWCINELIRSS-FGCSSYGSAQDFDDPNMFHLKLGYHQYYREFL------SSNLTQRDIDRAKIKKIR------QQCISQLK------APNCIDEIYSPI------GDSFSV------KD------KSDYTIIVDAPSVPFENNEFSLEIALLDYLIYISSSLNFWFGISIISVV--DHF-IT------T------LF--EWID-S------KKLKSKETK------PPSPS------PQFKAKIVVQPIRSR------V------LTKFNSLNRE------RFSHYYSRYHSINQQ------TuENaC98/1-445 ------MKGQKNG------RFDYYQTPSR------SNQTSQIFSVPHN------QMFPSH------HIRPKYTRTTSR------LSSIP------STPSATSSSTQ------CFS------LLRAALDRRQFS------LR----TISVMLLSYTGAAA-LATLL----TAEYFHYYTTTRIEIISPNHSELPAFSVCLFYIL------PEIRL------EKTHDNWLESSLTLGEID------SRL------PKFDEFVIDCK-VLDS------NYK------YKS------CINITPNVT------EYLSLYSKCYTL------FE----KM------DP------IVYEDGKV------GSNFLIKLRLNTKNLTTNT-L------AIFINHRTEELREAYGNP-GFLQLECEN-KNEAIATYERTVIKSLESPYDSGCRDYS------KEPCF------NRNTCLKRCILNSLHKS-IKRFDTNRYVKLFS------NRLDGRFGVRNE------SFDT------QVCRNKFT------QPPCNEYIYRAI------SGIQIY------SPFM------P------NGTFEFSLSYPLGTEIRVQYVPYRPFLDYLIFVFSVIALWTEFSVSRTL--YKF-SN------C------LQ--SGIL------KRMRDFICYR------TuENaC97/1-554 ------MSIRTFD-EMAKVAIQ-RNGISP------DHVTFDSTPSN------WPQLQPKFSSERN------PLTSPKGAFA------GKSYSTMAKRSVQKDSRTL------KADEAK------RGIGNSRQPR------HR-----RIAFLFSYTGGFI-MAVMV----TQSYLNYETTTNVYIAAPQDTELPSVSVCFFYRI------PHLKH------EKGEDGKNLTNLTLGQIN------QLL------PTFNEFVKDCQ-VLDS------KNN------YTS------CMTVYQETSSTHI------SYLSLFSKCYTM------FE-GME------TP------IKYTKKEI------GSNWLLDITLNVSRVPTNK-V------GIFLTHSTNELDESLGNP-SFLQFDTKN-NNRATVTYERTRINKLPPPHDSKCFNYETSD------STHDCK------NRATCIRKCIVWESYEN-SKAWVDQRYVRIED------HYLDGRFGIESE------ANFT------EFCFNKYS------EEPCVDYLYNAI------MASQFY------SPFR------DQ------VNSTFQINVAYPLGMETVVEYVAVQSLLDYICFVCSIVSLWTEASMVRIS--EYL-LD------V------ST--SLLL-RLLETEH------FNDYQIDSETNHINNAQ------GSIAVI------TSFKPTEININTSMAGYDVIPNSVGVGNAVGIGVAGGNNDNQLMEEPTSTRNIYKSFPPRYNKPSYIE------TuENaC112/1-513 ------MVNSVM------SSLPNH------SYRETRSRVSQR------FTYP------YYPGARSSSSAW------KPVKPFSAS------PWRHFLSRAIS------HR-----AFAVLVCYTGALV-QTAVL----TQIYFEFKTSTSVQIKSPQQTDLPAISICFFYKI------SGLKL------IPLGNNISQTSLTLGEID------SRL------LSWSEFVKNCY-VMDS------EYV------FRP------CEDISQEKA------EFISLYSKCFTL------FT-NTT------VP------ISYSKELI------GSNRMVDFTLNVSHPVITK-V------GVYLTHPISELDDVLGTP-SFVYFDTKH-NNRATISYHKTIIHSLPEPYESRCYDYS------KLPCK------ERRTCIKKCTLEMSYNE-SKGFINRRFTKISD------EVKDGRFGIRNH------LDNHT------GFCNAQFL------QAPCNEYLYQAI------MGSEFE------SPFI------N------RGDYRVSIDYPLGTETRIQYVPSRSFLDYICFSASVLSLWTEISLIRLV--QLS-TK------A------MI--TFIC-RYLNND------KRIYPDDS------IKKTTLTPKSGSKTNLF------GTLSVDSI------TLSSRSLLNINSSNHG------GISVGG------NPSPSSISIYEVSPSRHRFNNYFQSENNSDKK------NSR------TuENaC96/1-456 ------MLVKPKD------SRIDEE------SLQTLTL------YH-----YFALLASFAVAVI-SASFI----IESYLSYPTITTVKIERPRDTELPSISLCFFYEI------DQLKK------PSYRNGRQIYPLNLSQID------ERL------PKLDEWIKSCK-VLNAT------TYR------IHP------CLQYYNHTV------EYLSVHAKCYSF------FE-SLP------EQ------IFFKSEAV------VGRALLDVTFNNTVINSDH-I------GIFITHTYAELEDSLSNP-SFLQFNTTE-SNIAVTTFARTAIRNLPSPYHTQCFRYD------TLECR------HRSTCIRHCINKISHNK-TGTWHGPTYVKLAS------EFMDGYFTLYPH------EADQMIY------EQCQDEYQ------HEPCNQYLYEPV------ITSKFT------SSTV------Q------EGTFRLAVVYPNKPKVEVKLLHKTKLSDSLIFLAGIVHLCTGVSLLAIL--IALSIN------LE--SVVR-YFKQPDRSIYTFFLL-IFSKVFRINSESFHD------HQSNPSSLTEEWNGQSKML------KTARLNQFTSHRLVSPTTAK------SFTYYSH------TuENaC95/1-477 ------MANFSNL-----VSVK-RDIY------RKSKQDSKESEDNKHTL---VISSSPP------PIVYGKDKSCV------TQSTN------LH-----TYIILLCYLGALI-QGATI----FSKYLKYPTTNTVYIERPSETELPSISLCFFYSL------DEFQN------VTVIDGVEHYPLKLSEIN------ERL------PKIEDWILDCK-VLNNN------SYQ------YEP------CLNLWNYYV------EYLSLYSKCYSY------FE-SLM------PQ------IYYKSQFV------MGKWMMEVKFNISVIKSKR-I------GIYITHTYAELEESLGNP-SFLQFDTVE-NNQAGVTFQNTVVERLPPPYNTSCRYYE------HEPCN------HPKTCTRHCVMNMSYDN-YHSWFSRSYVKLRP------EFMDGHFTNRSE------KEMF------KNCSETYS------EQPCHDYYYLAI------LTSAFK------SEIL------E------NDTFQLSMAYPIAPKTQVVFQPASKLMDTLCLFGGQFYLWTSISLLCVI--SLLSWK------FK--KFFK-NVSND------VMLKRNSKLSHN------LKTCISN------TQLRPKVSVISKAAEDDAKF------KTVRLNKFTSHGLSTLMPPE------G------TuENaC114/1-447 ------MKIYTLK------PDF------FKRRNLHRNVDRQK------QP------AYSNDRSRFMIF------RLSQFFTYFGLIS-SLIIV----ISNYIAFRVTTKVDIRTYKKATLPSISVCFFYDIDP------KYGPTI------QESADHYHATRLTVKQIN------DLL------PTWDQFVPSCL-IVVPG------FHK------PVS------CTHLDPNIS------EYLNLYSKCFRI------FD-SSF------NK------LKYQNYHH------WGNQLVEITINKSVLTTSK-I------GVFLNNPTSGLENAMGNP-SFIQFDTSE-NNQASITFKRIKIKSKPYPYVTDCFDYT------QLDCK------QRIRCIHSCVGELHLAV-KNEWSYRRYIKLIP------QHYNARFSDRPE------LSFLS------TYCFNKYP------QQPCTQMFYLPE------LGTQIN------SPFK------E------NGSYHILINYPHGTEKIIKYFPGESFVNFLVHLTSVIGIWIFLPTIRAL--NIL-FY------W------TF--KAFN------FHQNVKKKLKLSHSSLK------NGWLSH------KSHPIRTRNQLSHAKKMSTR------NAARIAW--- TuENaC100/1-444 ------MKISTFN------PNLVY------NLSGNEER------P------KYPNDRPRRTIF------RTSQFLTYFGLIV-SSILV----IRHYFAFRVFTKVDISIYKETGLPSIGVCFFYDIEH------QHGPIL------QETADNHKITRLTVKQIN------DLL------PTWDQFVTSCK-VAVPE------LLT------YMS------CTRLDTNMS------EYLNLYSKCFRL------FA-SPL------NQ------IKYNMYHD------WASELIKIEINKSILTTSK-I------GLFLNNPISGLQNAMGDP-SFIQLETTG-NNLASVTFRRVQIISKPYPYETGCIDYS------QLDCR------ERKMCIHKCVGDTQLAI-KKQWNYLRYIKLQP------NHFNARFSDYPE------SSLFS------TYCYQKYP------HQPCNQLFYIPD------LATQIN------SPFA------G------NESFKISIIYPYGTEKLIEYYPVESFKSFIIHLTSVIGIWITLPVIKVL--NLL-FY------W------TH--RAFN------WQQNVKTKPKSSHLFLY------KGWLTRDP------KRQTIRTRHQLSYVNGLSTR------NFQRLTW--- TuENaC102/1-488 ------MVRIKPKLE------YSQKIVAKFRKS------AR-----FWASLVCIVGAVV-HTGII----SLNYLLHPIGANLEMKTINNFALPSVSICFDYLR------KGFRY------I------DHPVHPIKVSTLTVKEIN------DGL------LKWEDLIIFCK-VLDV------NYN------QVD------CESLMVQPENINNTNQHPII-LEQLSHYLKCFTL------FS-GFN------DT------ISYDRDKV------GDSPLMDIRLNTFNLSLGKRL------GLYILSPYEELDESISNP-SFIQFDAID-SNQATVTFESIFIYQFQSRFYSNCFPYV------SEGYQKY------GCGSISACLNQCLFEATYNQ-TGSTHYRRFIKIKD------QYSDARFSLMND------SEFQ------RKCMARYH------PTPCVYHRYTPL------LTSQYL------SPYR------N------ANVFQISILYPETIDVIIQYGLTQSLIEYLIFLLSTVVLWTELSLNKII--SSFLLS------AY--SCYE------QVCIKLTQTSNS------LAVKLRLKSDAKTGIKPTSKAKSR------TRLGTMFDVKP-----HARLDTTPDNSTGVNLGIYRSVGGKVTRKKLLSSKRLNNS------LLDYY------TuENaC113/1-455 ------MMAVPMK------KP------SNPLTKSLIFTH------DK-----LVPVIICIFGSTT-QVLTL----FALYFSWPTTTVIEVYRPNVINLPSISLCLVFT------LSADDVEK------TIAARNQA------NETGREVSIYDLTLDELD------QLT------VDLHHFVKSCR-VANA------SID------SNQ-----LFNMVDCENVSPVK------VAMTPFLKCFTY------FS-GKT------NP------YKYYRNDF------YDETFLKVEVIANHTKVTT------LVFVHDNDEEVVFNNGSP-DMTVLDKTF-YNHFILTYYTRTNTELAFPY-SNCMDYD------EVHNK------SRRTLVKQCMYTQVYLE-YSAFPERSLVSIPN------DLSNVTFDQEIP------MSKFR------TVCETLYH------QPECKTRLFDAR------ILQSEF------DATI------D------PGLVLIEFGFPLGLQSDITKSKKFNDIEFFCYVASIISLWLEVSILSVT--KFL-FHN------LR--KLVL------NILRRRREANKK------RVLLTRHQQKHRKMSKSKAK------ISWISNVYG-----PEFHHFYP------KYMRSYGPVYPISYY------TuENaC99/1-455 ------MMAASLK------KP------SNPLTKSLIFTH------DK-----LVPIIICIIGATT-QVSTL----FTLYFSWPTTTVIELYRPNVINLPSISLCFVYK------LSKDVILE------TIFSRDTL------SDIGQEISSLDLTLDELD------HLT------ADLHNFVESCK-VANA------SID------ANQ-----LFNMVDCENVSQVK------VALAPFLKCFTF------FA-GKH------NP------YEYYRNDF------YDDYFLLAELNANHSSGLS------LVFVHDNDEEVAFNNGSP-DMAVLDKTF-YNKFVLTYYTKTNSELGFPY-SNCMDYE------EVHNK------SRRTLIKQCMYTAIYLE-YLAFPELSLVSVPN------YLSNVTFDKGIP------TSKFR------AACEAIYH------QPECKTHLFETR------ILKAEF------DPTI------D------PGIILIKFGYPLGLQSDIMKSKKFNDIEFFCYVASIISLWLEVSILSVA--KFL-FHN------LR--KLGR------NILRRRREAAKK------RALLARYQQKQRKMNKSKAK------ISWISNGYE-----REFYLFYP------KYMRSYGPVYPINYY------TuENaC103/1-405 ------MKQSTQR------NV------LKRIRQSLIFTN------DQ-----LIPFVICFIGTVI-EITDL----LTIYFTFQTMTSVEVYSPDNVILPAISICHKYD------LDEDLIRE------KIPRFNG------SFELNKEDIRFNLTINELN------EVT------SKPKDFIHSCK-VANT------SFT------NDK------PDFVDCFQVEPVQ------INLDAHRKCFTL------FF-GEQ------SS------FTYSRVLF------TDIFIVKLQLNTTVTNHPY-F------QMIVHDHDQEVTSNRGSP-ETVLLDTHR-FSDFVLTYYTEQIIAMGKPY-SNCIDYF------ALYGQ------TKHDLIKKCIFNSIYED-YGALDDEILVRLPL------EHNDTNFIRGVR------TSRYR------SACERNHT------ELECTTKSFQLI------LLRSLQ------GAEKAP------G------GGIISIELGYPIGMQTTVTMVPKQDRVEYFCYMASMINLWLEISVVGVV--SFT-FKK------VR--QMAM-KLI------VIVRKK------IDQ------TuENaC129/1-431 ------MAIRRRY------HKSTTM------IR-----FFCWVLSSCGLAW-QVQQI----SNIYFEYQTQVDMIIESPRNITMPGLTMCIQLI------YNETILKL------HYPQSEELIDW--K------NKENASFSALRYVPINVLA------KLP------TTPVKIFCK-APFP------ELTPLEEYK--SDPKN------CEHFAKIKNTIHFN------PAQDDFFHCSTF------FF-SPT------LP------SPYQVVKA------DDKDFYKIEIYTESASYLDILVSNTNKT----TVVAFIHNPMEILHVAEA---DSFNFYTEQ-TENMILTTSKIITELLPSPYRTDCYDYT------GAEY------GRTGCIFDCRKARAESLCSEIWPWDVPAD------VNCNRSFS------LRGKNCTAVMGD------NRCSDE------CKNQCTNYWYSTT------LIAAIE------KRTP------SNLTKLFVRRPFGVEITYKYLARMGEIEYLCYIASCFGIWMGISFLDIT--YLL-TD------S------VN--KWIT-K------RETRILVLS------P------FDKRP------GRSKISLGSLRTA------TuENaC107/1-449 ------MSLQTSR------RFRLKP------SELKIQQTLVE------RSKNEKRQSHVEN------DFQLNRPSLDFVI------YKPTEYNFNSKNIDDRE------KSKTKLCHYSYQ------AK-----LISWLTATIGLIW-QIHQV----SVIYFDFKTRVDIEIVPHQNITMPALTICTDLM------AHPSILR------YFPSF------NLSKDARDYYRYLRPSKLL------EFP------AEPVKVDCR-TPFP------ELIKIDPSG--TDN------CENFVAPRVSLHYN------WETNRVIRCNTY------YY-QEP------GK------KPMEVIHG------NAKDFYQVRLFSQGNHS---F------AIIVHNPIEILHVIEA---DTFHFWSQQ-TLSIILSTTKVITHLLPAPYRTDCVPYD------DQEF------GRLSCVYNCRIKQAIRD-CPIWPKDVPVT------KNTDLPFA------VEGKVCWAPER------HYCSQKFL------CKAQCINHWYTTT------LISVTE------KRSN------SNLTRLYVRRPSGAEFVYNYGPRLTQIEFICYTASCFGIWFGISVTDML--RFS-LH------Y------GT--KRFV------AHS TuENaC108/1-457 ------MVTSNINLKNARLASSRSYTLFP------GNL------SQGEPR------KFKPTFINGSMRQLTSKK------YQLKASSFFW------IK-----FVSWLIASVGLFW-QISSV----SMIYFRFPTRTDIEIDSPRNVNMPGLTICLKLI------TPSTQIVP---T--SSAISLYNQ------TVGPLSNNLRYVPINILS------KLP------HEPVEITCK-TPWP------ELVPINSSA--GDD------CENFVTPIETIQYD------YEEDQLYRCTTY------FH-QRP------NK------SEINVITK------NSEHFYRVNFQTSQNYW---I------AVYVHNPVEVLHLNEA---DTFRFSTKE-TEQITLMTTKMTTYLSRYPYQTDCIDYE------EQVY------GRMSCVYNCRCAMVRKV-CPIWPYDVPAD------PKKSLPFF------VSSKSCQTPGR------YLCSIKST------CKNACLNKWYSTS------LINRKE------KSNS------SNLTKFYVRRPFGAEVNYYYTARMERIEFFCYIASCFGTWLGISFADLI--KFS-GN------W------FE--KQSI-E------KSRVNIIKV------AA------VKLP------SKSFKIKSK------TuENaC93/1-442 ------MSKTSPT------KQSNAKD------VS-AINEPSD---IN------DSSKTGNFKGKSSKCNKR------FNLLK------HLLKIKNHPLTR------LN-----VIACILSAVGLIW-QIFQV----STVYFSYQTRVDIIISTPQALVIPGFTVCLDIV------PNWTIIKQ------YVPNIEP------SSPILTSTLTNLPINVLA------SMA------TVNVSLSCR-TSVPP------NLS---PHV--SDL------CESFSEPKWTVHSS------ARYDLVKKCVTY------FY-NAD------PS------HSIRMLDF------DARDFFTLRVYSEGNHS---V------TVFVHNPREILPFEES---DSFPFFTKQ-AARLVVTTSKVITSLLPAPYRTNCVSYN------ETEY------GRTGCIYSCRLKEAQRN-CPRWPYNVPAP------TNTTVPFR------IRGRDCAGPLR------YTCSDRSV------CPNQCNNVWYSTS------LTYLRD------KKDP------N------DYITRFSVRRPLGIEFEYMYGPRLDAIEFLCYVASALSMWMGISVFDLT--LLT-IT------W------TK--KRVP------AKTRKIEGVVVLGS------TuENaC94/1-429 ------MGANKRP------EN------INITPGSPGL------IVP------SW----LRPLTI------LR-----VSSWILCSSGVIW-QIVSV----SKIYFEYTTRVDINITVPSRLSMPAISVCLHIL------YDKKVLSKF------YSPPESIP------SSLASIPFHILY------QLP------TSKVKINCT-VPNNTY------ELPKLDPEK--GFE------CENYSPVLVTIHF------TEGINLRKCFTY------FF-RNA------TT------EPFVVHYA------NAKDFFTVDLISDQNNS---V------SIFVHNPIEVLLVSDA---DTFTFHTNS-TAALVLSSSKLITKLLPPPYRTGCETYD------NELY------GRTGCIFKCLKDNARER-CGVWPASVPAD------TWGNFYFI------SPDGQC----DYGREKK------DECAQKDI------CPNQCLNLWYTTT------LVSVQK------QTDL------SNLTRIVVRRPSEVEFTYIYVPKMDKIEYFCFVASCFGIWLGISFIDFL--EYI-IM------L------LK--GKLD---P------PKPQIKVLT------PTYIYF------LRDRP------NSLRSIMSIM------TuENaC119/1-502 ------MV------PDY------IKDNWQTLLSYAFASIGLVW-QVSSI----SKVYFNYETQVDISIGVSTKIAMPGLTVCLEID------QLSFGNATR------QDIEIAA------QFLSQSSVS------SLNYLTKYEYSYLPINLLA------NFA------SPDIKLYCN-VPAT------ELPRLNTSL--DWT------CGNIVPTKITIHYM------LITGTIARCVTY------FY-QDS------AG------GEFDVFTN------SAKDFYVLKIDTFEPKV---I------SIYVHNPSQINQISDA---DTITFSTGE-LNEIVLLTSKFVTLLLPPPYRTACRSYD------EFEF------GRLGCIFDCFVKETNKR-CPVWSILSPAN------VSVALPFM------RKVSESNGTSDCHVKEK------NFCFSVCS------QPECKGVYYTTT------NVYLSE------RRSL------AN------SNSTLVYVRRPSGVEFGYKYKARLAPIEFFCYLASCLSLWYGISFINFY--RFL-TG------W------LR--NNLI-SF-N------FISQQTQVQS------PSQLAAISNKPSSINNMKIQYLHPYQPNQNRYFNKNPIHYHQPSWLAEHSNIRPKAPQ------ISTLR------NKWSPLSPQRAV------YDKKKFNLSSVQIYSAW------TuENaC106/1-422 ------MK------RK-HLPNLLCWLFASLGLFW-QVYQV----SEIFFGFQTRVDIEMDAPINLTMPAITVCLPLD------PHPKTLN------HLFHTRNL------TFAQMKEEVTYLPINILS------TLE------TIDVKVFCR-TKYP------RVIDGAPD---GQP------CDLFGETIHSMQYN------QAFKEITHCTTY------LH-QKED------RPLTVISN------EAKDFYQLEIYSAKPNS---F------YVYLHNPIEILNLPES---DFLTIFTNQ-SSDVVIVTSRIVVSLPSYIFFTNCLDYT------DVMF------RRQGCIFECRNRIALAT-CGSWSSEVPAP------VNSKLPFR------SRQHTCPSPSD------YKCESFEI------CPVACKSSWYSSN------LVWNHF------KETR------SNLTRFAARRPYGLEFVYNVTPYLATVEYSCYVASCLGIWFGISYSDIM--LRM-FN------L------NE--KSVE------S------RKSHKPYKN------DKQRSDWSKPQAYPKGYK------RSP------NKILHRKVSRVWHIDVLR------TuENaC110/1-537 ------MLSSKKYFETIE------EASVESFNAINIAKNNGVSG------DDKAVKTTKSLE------LFK-----ICYNLVTIIGFLW-QVYSV----NYIYLQYNTVVNIIVSKMTHYNMPGITICLDYD------MEDKETFKL------FYPDHNM-DNY------SPDDLRLIFLQTPIHSIY------RNA------HTVGRVSINCT-VKCS------RDS--RFVKPSSSFQ-STSFDSASFCVDIPCSIYSKPIETLSW------ARNNVIRRCTTY------FT-WNS------TS------TPLREYSE------DGRELIEFNVASNGSAV---V------IFAMHSGKTLPWTERE---DFSSLDIDR-YRRFTIDYSVIIFELLPRPYKTNCSHYI------EYGVF------GRTYCVHSCERSMFRRE-RGTWPLDVPAP------VNTSLSFF------PHGSGLRRERAFPLKTF------AACSKSCI------QPECSSYIITFT------TKNQDF------IPNHDNKT------QLRSSIFVNRPRSYAISYIHSPAINFIEYFTYISGSFSLWFGLSALSIF--NVL-PR------ICEGNKKPMK--RPIA------VDKLDKRFWQTSKYVNG----FYSNYKHIETKVIFDN------SMDLSHDSNPTDKSIDSTNPI------FLSMISTGR------RGNGKKHSLTTVFQTFEAHRI------IY------TuENaC109/1-493 ------MKFIISL------TKKINAIRNNRW------AK-----LTLFIILMSGMAW-QVYQI----NMLYLRFDTVVDINVERQFHIQLPSFTICMDLDL------DALD--PLKE------IYPDKQLSNNL------TSDEKRKLYRSAPIDLLF------KYA------VIQSDLTINCL-LICS------QNS--RFT------NGS------CVDVPCQDYSPVRKTIAW------ARNSALRRCDTY------FHWNDPSRS------NS------GEPFMEESN------GERDLINFNITKASNEQAS-V------IFSMHDGSLVPWTEDQ---DFSSLHVGL-MSIVSVNYQLTRIMLLEPPYKTNCRKYP------KLS------GWVGCMYDCKEELNRKD-SNGWPLDVPAE------SNVSIPFV------PESRQL-GDPHLTHKIN------RECRRECD------REQCTLNEYSHY------LKYIQYNLT--GDPNIDPSQ------S------SYLTRVYIHRPFNFDVVYKHRPAIEFIEYFSYVGSAIGLWFGFSCLTFF--NFA-EK------F------FK--QLISGKKVPEK------APKTLMKKQGNTNET------STNTPKRIKKRPPN------I------TLTPPRTN------NMILPISTNLSPTYKSFNQSPDDVVRFNG------PLTS------TuENaC122/1-623 ------MLSRFNE-KLLEFESN-EFNIL------NHFQQKSNQF------IKPTDTNKFHLYNTLNNEYKVNWENILNPPGNGYLQPSSPIEPLNYKDPIYIDKQENLKLPGTKGDEDEKKDVKKEEKKDDKTTQEPI----KQPDQPKTIQTLKPQRLKSGSSKVRWSLSDHHDDDSLDLSIFEHENHNR------LQLIFKFVFR------LK-----TVLLILSVIGLVY-QTLEL----SETYFRYPTIVDVIVEQNDKVIVPSITICTPMQI------MPSNLEKMFS------DRPEVRR------VLSRFDAD------EKMKTKEK------QAKKIDYLRRYLQSSYLSRVTVNLST------YDELS------VQENKFVDSCY-LSVLN------SSD-AEIR------LPCRNFSRPT------VTFTSNEKCFTY------FG-VTN------KQI------ESIDD------VISFDEDGSAA------TAQISVVLRLNVDFDDNYDIS------LPSLLYIHSSNEIMAKSNGFA------LES-NKKYNVFYWRTVSERLPPLY---CREYQ------SSILY------PQSQIDCVNRCSTEHTYLY-CRCLMFKPPLRLETVPLS-ARIC-PQLDGSFL------RSCKRMLQG-LDPKACRSRCTSACIEEAFDYSVTTS---DISPEE-----VLKISGSIN------Q------SGLIEIHVTRKLKPDVFYKQKYQLEFEQYFSNFCSLLGFWLGITVLTFY--DQL-KKNTIRLYRLLCY------VK--TKIK------HKKRRVKPKSRN------I------TuENaC91/1-478 ------MIWLPDN------CG------NNQANSELSKSNNKPKRLT------SRLVLDGIKHFL------IS-----YWVTCLCIFGCFV-QIFFL----TRNYFSKNVNYQVISLNSENITVPEVIICTPIH------TVLDYGKLVT------ERASLFN------NSCLNSSSV------DKCVL------RKFK------IPSLDFIIRQNFDITSIY------PFL------IKSNQLIVNVY-IHGFPD------VLA------NGV------CKTKDLISY------PNVCYKITCS------EEPA------NK------INVRRFVPSF------IPLYESLISFNLNNSVLASRTKAI------TIYLQSMDYPRRETEFDFGQSFSYDVDD-PLIVQFKFSIQRMFSLPSPYPTNCRKH------DHDLLMSYCLNNASILL-LNSSFPRRWIDLE------DFKGYHFG------LIPDMSDNNWDQLGLIK------DDCRRRYP------NPNCESELLTLQ------KMGLEA------SELP------AF------TKMIVIAIHAPDEPDLHFFVTPAMTASECIIMIFSILGFWFGFDVYHNS--NRI-SA------L------LI--RSVG------RSTETKVAK------ACNPNYRAIKPKLRQ------TI------KLYQLQRREKLFTVKSNP------TuENaC128/1-476 ------MKLTVKM------GKPKG------ELSSKKLNKPRLNKAASKRS------NRP-----FDPIIAVRCES------MVKIFQSRYRLI------IT-----LLFFVAAGYICLT-QIWIL----TKILSKLETVLVEKNIQSKNLVPPNFSFCFDIM------RFLNTTKLFK------NFPDILK------RTIEEQKA----IPYLKNWTLHQII------AEHELGEKFTLSMLTVGELA------SNM------LPFAAIMDKCY-FLTS------SLT------IAP------CNSSYFQ------TYIFNCLYCFEFTW-----FPGGRPN------KP------SPSFNPKGLQT------PGYHDLRLLDMHLNLSLVSGTNEI------IAFAHQPGRIPWKEESDL-LKLATPAST-SIVYGLTYAETVKINLGDPYPTKCTDENM------KVKAS------SDHSCWHNCSANQFSES-TGFYPRYSIIR------DGGDKKIL------DSYHKQERYNSLINKLQ------RQCVQKCG------RTECTERKFAVY------TLYNPS------RFSP------N------GKYVVIHYAPPSYNPRSYQLMPAFGVGLYWASVQNIISFLFGVNYHSMF--CFF-AD------A------FH--NWLV-SLYL------KTFNGKSQ------TuENaC23/1-483 ------MVKVKGYSK------LQGLGVRPEDVRI------RTTAFMDGQSKSKSKSNYSYSTW------IR-RLIGVALFTYAFIQCFK-QIREL----TQDFLRHEVIESVSDHIEDFVEPPNFSFCFDLL------STINSTQLLE------RHPSIIT------EIEQIRRE----EPQYHNWSANAII------HDYTKGPRLVFNLTSAEIY------DLL------PRFKKSLLSCQ-YLNT------NLK------LGT------CNWTYFT------EYFFNQMVCNEFIW-----HP-VNA------KPME------EIKFPYDGIKI------PGFQNTRFLALYLDLSHLLNVTVM------SVMAHSSVEVSWDPESST-LETYPEYGE-AKIYGLSYHKTSRKSLPSPYQSNCTDFK------DSPYF------SRQDCLKNCSVARFINR-TSRLPRYAIVR------SFDNNKIL------YDYEERERYQSLIQQLS------EYCNKICG------TSDCYSEDFSLT------VLYSPR------QSIQ------S------GKKLIIHIYPPTKPDTAINTSPSLTFQYYFASIGGTLGIWFGFSFYSCL--ICL-FD------T------TP--KLIT-TI------KKLCSHKQT------PNKPK------IEVNLI------EQTEVKQR------TuENaC92/1-501 ------MFKQRNK------LFVKRVPP------QAKDKIKNNVQWKPVSYDFYSLDSIKPVSVQ------IPIINE-----PKD--PLLKCLCFFKLV------LK-----TFITIICIFFWFY-QISYL----ANEYFKYEVIESRSHAYPTFLSPPDFSFCLNLI------GSLNATEMFI------RRPDVKA------AVLKVCST----RSNCSLSDQQAVL------ED------LTYGPKIVYSRMTTQELF------QLL------PGISSIMASCS-FLSA------NLS------SVQ------CDESYFR------TYMYSQKICYEFVW-----Y--SSK------SP------NKT------TPVFPANLINL------PGYTNIRLLAIQFNLTRFSSDALF------DIMIHPPFDLPWHPDKST-KESIIPNHQ-FIYQSLSYKKTVTQSLPDPYQSNCTDYS------ELPWR------SIQECILNCSLDKFIEI-SDYYPRYYPIV------KFDDHYLS------FDYNKRESYQPLIQQLS------EKCLDWCG------YTECFSEAYDII------SLNSGR------HVSP------G------MKMYNLQIFPSSQPTKLLRTTAVHSAEYFIANIGGSIGVWFGYSLYCLG--KRV-YN------F------IP--RIYQ-RMKLKF------ILKRNE------II------EFKP------TITKFKRPNKN------TuENaC124/1-450 ------MNWFLVN------II------IR--VIISVTFTVCVLK----SITDL----NYQYGLFRIAFHTSHNDSGLFEPPCISICIKVK------SLINVTSLIT------LYPGLVK------TAQRIIQD----NQQFSNWSFDQLI------ED------VNQGENLIFGELTLSQIA------KII------VPIEQLFDKCH-YLDE------NLS------NSP------CEDKYFK------TYFYDKSLCASFQA------WP------RL------GIEFSRSDLRI------PGYRGLILYQASLDLTQVPSVSEF------SVVAHRLNKIPWSQGDST-IELKLNPSA-VIYHYITFFETTTKLLPPPFESQCKIP------IKPYT------SVGHCLSRCFMSNFTRI-TGRLPHQYVIN------NPNNLKFL------HLYEGLEKYQTLVAQLY------APCKDICG------LTDCLSDAFEWR------KLGHPV------SSYH------P------KNYVNLQIYPPSRLPIIKEARPQIDWLDFFSSIGGVIGLYFGLSFFSMI--DLI-IN------F------SF-DNFIA-KLFGH------SKAKEEVNN------RVQPLNVE------V------LDFTQTDLSSGSYFVYSR------TuENaC127/1-477 ------MIISKAK------HIHAVNQSIY------SKKIKVPKRKYI----LPKIIR-----VFGLSLAMIIFSY-QTFLL----YSQYATNKIKIELGSRRVGEIQTPNFSFCFKLF------PDSNE------QVSTRSST-----AQYSSWRIQDIV------RDVKDKSD------TATTSQLL------HSA------GSLSSIISKCY-IRLS------NLT------VTE------CSRFSWA------KSILSKKLCMTL------EYN------EIFDQKDVIL------EAFDDSPLVFVRFNLTSFKMHNEF------VMVAHESTSVPWFPDPNF-FYINIKKN--YNLYSFSFSKVIVQNLPKPYHDNCRVR------PGNFD------DVSQCYDNCLVKQFTKI-VGAYPREYTVK------NGDNFKLI------ANYTQEVKYNDLSYQLY------RSCLPLCG------HTDCILTKYRLN------QRKEYH------LDSSS------DKTLDIQVYPSPLIVVIKYRKPVISDSNFISSLGGLIGLWFGVSFCSLF--NSM-SN------I------CN--KMIRSRNKVE------PALIARKQRVKRNR------TVNKFEPLGSFPKKHY------LALVGEMS------SNRTRFQLNSGSRINFHDQVDKH------TuENaC126/1-451 ------MKFIGSR------LPKLVK-----GIFFGFIGLLLIC-QIVHL----YQQYTLQEVKVETLYHRNSPIEMPNLTFCFKLL------HVLDIKLLFE------KFPDILS------IVKNISVT----NKDYTGRSYTDI------IVERDEILFDRLTTLQFF------DTV------KPIEELFKFCL-IRTE------NVP------SIN------CSLNWL------RRIHSKNLCLTL------RSN------ATFDYNNIVF------DGYGNSPLAFFLIDLTPLPLIKQI------LVAAHISEELPWFHQISF-AELIVNEDT-EYGYSLSFHKHVDINLPGSNLNGCNQQL------SNNFK------DVPSCYEHCLMGQFVDR-EQKYPRDFLIK------SGDDFKLI------DNYWVSQSYYNLTSKLY------RQCKQVCG------LKDCVEINYILN------KLKPSQ------KSQIP------GKNIKITILPSKLVTVIKSRKLVITFANYISSVGGLIGLWFGSSFYSLI--KLL-LH------F------RS--KSLE------T------RKMSKISKK------PKRLFHHRKVTP------VATI------AYKP------VNIEHIPRTHYLSRVNLL------TuENaC118/1-530 ------MAVFPSN------QVDIESGGNSAVNEKRSTSR------NCCNLL------FQ-----SVVFSVCCFLFIS-QSMML----VKVYLSFPTTITTNLTFAEIFDLPSVTLCFKSD------LKPGAVEAAN----EVFRRNFNA------DKAKEEDIKCNLMIPTIN------QVTGTF------EVS------PIPCHEIVPTLES------INFGLGKRCYTF------FS-KLG------KP------IRSSRDLKVRW------SRFSDEGGGNGLLTTKNGDLMTLEIEFGRKPNVEAF---TDDL----DASISIHQSNELPLSSQKIS------KLKP-GYNYLITFDKIIEKRMPPPFRTGCDQYKQTMNGKNEQVNTGKLVDERNFMGI-VSPHLKPPQSKYDCVDQCLLTLYRQT-CNCLPSDINVRRDL------LRSNDTFC------TNAKCQTLQIHRA----EFCATLPR------CKPNCEDELYNFVTEMA--DSQSTTMVLTHYINTQRHRTS-SRPINYNNGGAGYIPRPMVPNGQFQSYGLQEAGTYHGSLSESVPDIVNVLGTLSKAFVTVRKSSGPDVVYEHRPQYNYFDFVFQLMTLACVWLGFSIFSII--WKP-FY------I------IF--KIIS------FC--C-----CLSRKLQKTKPL------VTID------TuENaC117/1-491 ------MMIQGAN------NC------VR-----LIVKTAALVLCIY-QIAYM----LNYIIRGETRTRLRITQDPSVELPNVYLCFSVF------DILNVNYFRE------KYPSVVF------QEVDGRMQPK------MDFDIMRTVSTMTFEELS------KAL------LDPSKSLVSIN-PASSVDD---VYQR--QVF------PDD------CKTTNNLIR------DSMCIKISCT------KNG------SA------IVYDKTVIDN------GEAEGYLMQIKFNQLFRNVSTYS------SILVIPMNKDFTISSETP-LFLDINFEKPSFEMIFGIKLYRTEYKESDFTEQCTNYR------LQGYQ------NRIGKVHQCINNLTRDK-LNCPYYETIQPLESMEKE-IRTGLFETYLEFFN------PKKETREFYRNLFKSFK------SFCYKQSP------YPDCEEIIFRPY------KKRISY------GK------KNESTIVMRMTSQPTLSNIIVPYYDLDDFIVYSQSAIGIWLGISPIFVI--EWL-IDK------LI--TFLK------GS------QSRESVEEN------KVQDVSEPADDDKSADV------SQISNINVSRRSSEI---KNSNTP------KRQSRGNLKKQVLATTGIYHVLSRVNKM------TNE------

TM 1 TM 2 Positions 285-288 in cASIC1

Conservation ------+------00------00-----2242475447444-44415----41296263542253322430545*473735251------0012010100------0000010------00000000------001121121127463552------324------00321540011-0000------050------000------+42111300------12524322+2------001------00------61342112------0000001617223200000------72621114251212200-000001130-30222436123331233169093*348------25121622*13314211-03240012322------01222282------0000000000------12*13300------143*12219131------321100------00------231417171143233113221214261667544585774+547972124--000-01------0------41--2240------10000001------00000000------

Quality

Consensus MVKNTIEFIKLTFRLQLLLEFAWSEISF+++MS+MKILTKKL+LA+L+SSRRFIILP+ECK+++S+SHLN+LQT+++WNC+GII+PQNSNKFS+++N++++++++LN++L+RPS+VF+++SSPIEPLNYKDPIYIDKQENL++P+T++D+SK++Q+KPNL+RN+SRPKR+LDFY++DS+QPVSIQT++PYP++RSSST+F+S++++++++++P+SIF++S++NRP+DL+SLLSII+FKKLIEICHLPKLLK++LITSIIRLFCIIGCSINQIYLLCTNRT+NYLEFPVRTEVIYDYPDKIELPDIDICFPYII++SR++++QDENINKPVDVESILCANLDDALNLTKLFLF++++LDQGREICL+N++YRYPEEL++DNLPFEELCKKLN+KI+SKSNLTNN+IDDFNVK+D+SDC+K+F++SAIS++RLLKSTHPTTTKTGGGPLNVGGNNIGNSATFSGNSGAGNTSNIGAGGPNGPGSSGSPLPPRSKRQAWRNRGGGSGSGSTGNSGN++PS+GANLTGSKPPTP++PYLFSKFLG+NLTVKDIE+VTVNL++R+GF++++++ELTG+FLAVMANKDKKT++++GLGVS+YDPESLIDKIK++ANST++FNGLREDNHNLT+G+PS+D+TDL++SASL+++VPCKIKRYFSGTIHYN++++++N+PA+FLRISCLTY+W++FSLFEGNSSG+++RLLNGLSSCTAPWVRSVLRVNSSSEKDFDQS+KP++ILLDLLQSWLADLSRHHLSVARQLG+++SDLIVSCHF+GKKCY+IK+SRN+VIVAD+CYTYNMAESLISSATLS++SD+G+++GLPGPNSNEL+I++LNHSIFTSFGY++++TDETSFE+GALVRLHSPNDLPVGD+SSYGFFITLKKGK+PNTTTISFTKIV+NLLPPPYETNCRDYSDD++GKNEQVNTGKLV+EEGYKK+WAS++++GPYNR+KCLEDCLNNKSLNQ+TGTLFYDTVVELGKYSDHH+R+G+YPSDLRFNSPFL+++++E+++NNRERENYNELLSEIY+ELDAFEECSQLVT+++++K+++C+CQPECNSVTYSTEVS+VKI+G++SIE+LTHY+++FLD++SF+RPINYNNGGAGYIPRPMVPNGQ++SYGLQEAGT+++SLSRGL++IVNVLGTS++GLILIEPPSEPDIILKYKPKLTLSEYLIYIGSILGIWFGISIYDQLHVLS+SLDGT++++RLLCLCEGNKKPLKELKKISAKL+N+D+++FC++C+E++++ILRKSTKKVNS+LG++QIFPVNPT++SDK++++NNMKIQYLHPYQPNQNRYFNK++S++LSTI+LKNKKKVNPKSRSK+RKFFERRDYTNR+F++V+I+TISV++THE+++NN+LTLRP++R++F+L++Y+++R++TKRFTINNEQP+SYPRLL+KS++++C+VGI+V+GGN+++QLM++++S++NIY+++P+R+IFS+YY+DYL+SNQQAWPLTY+N+AR+WW+R+

Suppl. Fig. S6. Alignment of T. urticae ENaCs.

Alignment of T. urticae ENaCs using MAFFT v7.266 with visualization using Jalview. For comparison, cASIC1, for which a structure is available (Jasti et al. 2007), is included (first sequence in alignment); transmembrane domains relative to cASIC1 are indicated at the bottom in black rectangles. The position of the PPPW sub-sequence in cASIC1 is indicated beneath the alignments (positions 285-288 relative to the cASIC1 sequence). Default tracks from Jalview for sequence conservation, quality, and consensus are shown at bottom. Jasti J, Furukawa H, Gonzales EB, Gouaux E. 2007. Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH. Nature 449:316–323. a Observed Random assignment of sequences to CR genomic locations

3000 Clade A TuGRs

2000

Count 1000

0 1 2 3 4 Average patristic distance across all clusters b

3000 Clade B TuGRs 2000 Count 1000

0 1 2 3 4 Average patristic distance across all clusters

c 2000 T. urticae ENaCs 1500

1000 Count 500

0 1 2 3 Average patristic distance across all clusters

Suppl. Fig. S7. Chemosensory receptors in clusters are similar in sequence.

Sequence similarity for (a) TuGR-As, (b) TuGR-Bs, and (c) ENaCs is far higher in clusters than expected by chance. Shown is the observed similarity, as assessed with patristic distances from phylogenies (supplementary fig. S1 for TuGRs, and fig. 2 for ENaCs), as compared to 10,000 permutations of random assignments of CRs to observed genomic locations by CR type and clade (see Materials and Methods). In all cases (a-c), the observed sequence metric based on patristic distances falls far outside the distribution established by calculating the same metric on CR sequences by cluster following random shuffling of CRs to all genomic locations. a ENaC, intact Non-ENaC gene, intact Transposable element ENaC, pseudogene Non-ENaC, pseudogene

Scaffold 11 ENaC Cluster Position (bp)

2250000 2255000 2260000 2265000 2270000

(+ strand)

TuENaC57 TuENaC58TuENaC59TuENaC60TuENaC61TuENaC62TuENaC63

(- strand) b Scaffold 5 ENaC Cluster Position (bp)

340000 350000 360000 370000 380000 390000 400000 410000 420000 430000

(+ strand)

TuENaC49TuENaC81 TuENaC75 TuENaC77 TuENaC78 ETuNaC80

TuENaC70TuENaC71 TuENaC82 TuENaC74 TuENaC87TuENaC76TuENaC72TuENaC73 TuENaC79TuENaC50

(- strand)

Suppl. Fig. S8. ENaC clusters on scaffolds 5 and 11.

Genomic organization of two T. urticae ENaC clusters with (a) head-to-tail gene orientations (scaffold 11) as well as (b) a larger cluster with evidence of multiple rear- rangements (scaffold 5). Intact genes, pseudogenes, and transposable element sequences are denoted as in fig. 4 and in the legend. All ENaC genes shown are intronless.