Cumulative Contents, 1983

Volume 47, No.1 January 1983 I STEEL, G.G., COURTENAY, V.D. & OXFORD LYMPHOMA GROUP. Prognostic PECKHAM, M.J. The response to chemotherapy factors in non-Hodgkins lymphoma: The of a variety of human tumour xenografts. importance of symptomatic stage as an adjunct to the Kiel histopathological classification. 15 STRUCK, R.F., DYKES, D.J., CORBETT, T.H., SULING, W.J. & TRADER, M.W. 103 TRENT, J.M., DAVIS, J.R. & DURIE, B.G.M. Isophosphoramide mustard, a metabolite of Cytogenetic analysis of leukaemic colonies from ifosfamide with activity against murine tumours acute and chronic myelogenous leukaemia. comparable to cyclophosphamide. Ill CHILD, J.A., CRAWFORD, S.M., NORFOLK, 27 MUINDI, J.R.F., NEWELL, D.R., SMITH, I.E. D.R., O'QUIGLEY, J., SCARFFE, J.H. & & HARRAP, K.R. Pentamethylmelamine STRUTHERS, L.P.L. Evaluation of serum beta (PMM): Phase I clinical and pharmacokinetic 2-microglobulin as a prognostic indicator in studies. myelomatosis. 35 FORD, C.H.J., NEWMAN, C.E., JOHNSON, 115 EL-DEEB, B.B., BURNS, S., ROBINSON, R., J.R., WOODHOUSE, C.S., ROWLAND, G.F., HAMMOND, E.M. & MANN, J.R. Serum SIMMONDS, R.G. & REEDER, T.A. dopamine-,B-hydroxylase in children with Localisation and toxicity study of a vindesine neuroblastoma. anti-CEA conjugate in patients with advanced cancer. 123 BINDON, C., CZERNIECKI, M., RUELL, P.. EDWARDS, A., McCARTHY, W.H.. 43 EMBLETON, M.J., ROWLAND, G.F., HARRIS, R. & HERSEY, P. Clearance of rates SIMMONDS, R.G., JACOBS, E., MARSDEN, and systematic effects of intravenously C.H. & BALDWIN, R.W. Selective cytotoxicity administered Interleukin 2 (IL2) containing against human tumour cells by a vindesine- preparations in human subjects. monoclonal antibody conjugate. 135 SIKORA, K., ALDERSON, T. & ELLIS, J. 51 BEN-HUR, E., SHAW, J.J. & BLEEHEN, N.M. Human hybridomas from patients with malignant Enhancement of thermal killing by polyamines V. disease. The response of EMT6 multicellular tumour spheroids versus monolayer cells. 147 VAN DE LINDE, A.W., STREEFKERK, M., SCHUURMAN, H.J., TE VELDE, E.R. & 57 TWENTYMAN, P.R. Modification by WR 2721 KATER, L. Divergence between the occurrence of the response to chemotherapy of tumours and of antibody and cellular immune reactivity to normal tissues in the mouse. cervical carcinoma cell lines in preinvasive and macroinvasive stages of cervical carcinoma. 65 ROJAS, A., STEWART, F.A. & DENEKAMP, J. Interaction of misonidazole and WR-2721. 2. 155 ASTOR, M.B., PARHAM, J.C., HALL, E.J., Modification of tumour radiosensitization. TEMPLETON, M.A. & HARTOG, B. A 3-nitro triazole as a hypoxic cell sensitizer. 73 ANDO, K., PETERS, L.J., HUNTER, N., JINNOUCHI, K. & MATSUMOTO, T. 158 ROSSOWSKI, W. & SAHAI SRIVASTAVA, Inhibition of artificial and spontaneous lung B.I. Ectosialyltransferase activity: a marker for metastases by preirradiation of abdomen II. certain human haematopoietic cells. Target organ and mechanism. 161 WALKER, L.C., TUCKER, D.F. & BEGENT, 81 WEISS, L., HOLMES, J.C. & WARD, P.M. Do R.H.J. Identification of PEG-precipitable serum metastases arise from pre-existing subpopulations factor associated with malignant lymphoma as C- of cancer cells? reactive protein. 91 LEONARD, R.C.F., CUZICK, J., 165 BOOK REVIEWS MACLENNAN, I.C.M., VANHEGAN, R.I., MACKIE, P.H., McCORMICK, C.V. & 167 ANNOUNCEMENTS Volume 47, No. 2 February 1983

175 IJIRI, K. & POTTEN, C.S. Response of 269 SECRETO, G., RECCHIONE, C., intestinal cells of differing topographical and CAVALLERI, A., MIRAGLIA, M. & DATI, V. hierarchical status to ten cytotoxic drugs and five Circulating levels of testosterone, 17f,-oestradiol sources of radiation. luteinising hormone and prolactin in postmenopausal breast cancer 187 TWENTYMAN, P.R. & WORKMAN, P. An patients. investigation of the possibility of 277 TOMLEY, F.M., ARMSTRONG, S.J., MAHY, chemosensitization by clinically achievable B.W.J. & OWEN, L.N. Reverse transcriptase concentrations of misonidazole. activity and particles of retroviral density in cultured canine lymphosarcoma supernatants. 195 MURRAY, D. & MEYN, R.E. Enhancement of the DNA cross-linking activity of melphalan by 285 MOLE, R.H., PAPWORTH, D.G. & CORP, misonidazole in vivo. M.J. The dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice. 205 MORGAN, D., FRESHNEY, R.I., DARLING, J.L., THOMAS, D.G.T. & CELIK, F. Assay of 293 TISDALE, M.J. & BRENNAN, R.A. Loss of anticancer drugs in tissue culture: cell cultures of acetoacetate coenzyme A transferase activity in biopsies from human astrocytoma. tumours of peripheral tissues. 215 EVANS, B.D., SMITH, I.E. & MILLAR, J.L. High dose cyclophosphamide treatment of human oat cell xenografts in immune deprived mice. Short Communications 221 SILVESTRINI, B., HAHN, G.M., CIOLI, V. & 299 MORIYAMA, S., KAWAOI, A. & HIROTA, N. DE MARTINO, C. Effects of lonidamine alone Gamma-glutamyl transpeptidase in putative or combined with hyperthermia in some precancerous thyroid lesions of rats treated with experimental cell and tumour systems. diisopropanolnitrosamine. 303 PINKERTON, C.R. Is folate absorption 233 HASTINGS, R.J. & FRANKS, L.M. Cellular impaired by high dose methotrexate? heterogeneity in a tissue culture cell line derived from a human bladder carcinoma. 307 MCCLUSKEY, D.R., ROY, A.D., ABRAM, W.P. & MARTIN, W.M.C. T lymphocyte subsets 245 KERR, K.M., ROBERTSON, A.M.G. & in the peripheral blood of patients with benign LAMB, D. In vitro thymidine labelling of human and malignant breast disease. pulmonary neoplasms. 311 SWERDLOW, A.J. Epidemiology of melanoma 253 SMEDLEY, H.M., FINAN, P., LENNOX, E.S., of the eye in the Oxford region, 1952-1978. RITSON, A., SIKORA, K. TAKEI, F. & WRAIGHT, P. Localisation of metastatic carcinoma by a radio-labelled monoclonal Letter to the Editor antibody. 315 KAY, H.E.M. Planning and comparisons in 261 CASTAGNETTA, L., LO CASTO, M., clinical trials. MERCADANTE, T., POLITO, L., COWAN, S. & LEAKE, R.E. Intra-tumoural variation of 319 BOOK REVIEWS oestrogen receptor status in endometrial cancer. 323 ANNOUNCEMENTS

Volume 47, No.3 March 1983

327 HABESHAW, J.A., BAILEY, D., STANSFELD, 361 JONES, D.H., BLEEHEN, N.M., SLATER, A.G. & GREAVES, M.F. The cellular content of A.J., GEORGE, P.J.M., WALKER, J.R. & non Hodgkin lymphomas: Comprehensive analysis DIXON, A.K. Human lymphoblastoid interferon using monoclonal antibodies and other surface in the treatment of small cell lung cancer. marker techniques. 367 BURTIN, C., NOIROT, C., PAUPE, J. & 353 TESTORELLI, C., CANTI, G., FRANCO, P., SCHEINMANN, P. Decreased blood histamine GOLDIN, A. & NICOLIN, A. Serotherapy of levels in patients with solid malignant tumours. L 1210 murine leukaemia-reasons for ineffectiveness of in vivo treatment by L. 1 monoclonal antibody. Short Communications 373 BRATTAIN, M.G., MARKS, M.E., 419 ROHATINER, A.Z.S., PRIOR, P.F., BURTON, McCOMBS, J., FINELY, W. & BRATTAIN, A.L., SMITH, A.T., BALKWILL, F.R. & D.E. Characterisation of human colon carcinoma LISTER, T.A. Central nervous system toxicity of cell lines isolated from a single primary tumour. interferon. 383 BIGGAR, R.J., CURTIS, R.E., HOFFMAN, D. 423 JEHN, U., KERN, D., WACHHOLZ, K. & & FLANNERY, J.T. Second primary HOLZEL, D. Prognostic value of in vitro growth malignancies following salivary gland cancers. pattern of colony forming cells in adult acute leukaemia. 387 DURAND, R.E. Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its 429 MILLER, W.R., STURGEON, C.M. & mechanism of action. WALKER, R.A. Carcinoembryonic antigen (CEA) in explants of human breast cancer: 393 PHEASANT, A.E., BATES, J., BLAIR, J.A. & Comparison of immunohistochemical detection NAYYIR-MAZHIR, R. Investigations of tissue and release short-term culture. folates in normal and malignant tissues. during 433 MORRIS, I.D. & STEPHEN, T.M. In vitro and 399 SIDEBOTTOM, E. & CLARK, S.R. Cell fusion in vivo interactions of methotrexate and other segregates progressive growth from metastases. antimetabolites with the oestrogen high affinity 407 OOSTERHUIS, J.W., BAGASRA, O., receptors of the rat uterus. KUSHNER, H., FOX, N. & DAMJANOV, I. 439 TERASIMA, T., YASUKAWA, M. & The effects of regional factors on the growth rate KIMURA, M. Development of insusceptibility to and the differentiation of mouse teratocarcinoma. serum factor during the radiation transformation 413 PRIME, S.S., MACDONALD, D.G. & RENNIE, process. J.S. The effect of iron deficiency on experimental 443 BOOK REVIEWS oral carcinogenesis in the rat. 447 ANNOUNCEMENTS

Volume 47, No. 4 April 1983 455 VESSEY, M., BARON, J., DOLL, R., 503 BOCIAN, E., LAVERICK, M. & NIAS, A.H.W. McPHERSON, K. & YEATES, D. Oral The mode of action of cis-dichloro-bis contraceptives and breast cancer: Final report of (isopropylamine) trans dihydroxy platinum IV- an epidemiological study. (CHIP) studied by the analysis of chromosome 463 DURBEC, J.P., CHEVILLOTTE, G., BIDART, aberration production. J.M., BERTHEZENE, P. & SARLES, H. Diet, 511 HARLAND, R.N.L., BARNES, D.M., alcohol, tobacco and risk of cancer of the pancreas: A HOWELL, A., RIBEIRO, G.G., TAYLOR, J. & case-control study. SELLWOOD, R.A. Variation of receptor status 471 VAN STEENSEL-MOLL, H.A., in cancer of the breast. VALKENBURG, H.A. & VAN ZANEN, G.E. Incidence of childhood leukaemia in the 517 BARBASON, H., RASSENFOSSE, C. & BETZ, Netherlands (1973-1980). E.H. Promotion mechanism of phenobarbitol and partial hepatectomy in DENA hepato- 477 BLEWITT, R.W., ABBOTT, A.C. & BIRD, C.C. carcinogenesis cell kinetics effect. Mode of cell death induced in human lymphoid cells by high and low doses of glucocorticoid. 527 KOCH, G.L.E. & SMITH, M.J. Concanavalin A 487 acceptor glycoproteins: A new type of marker for GRONOWITZ, J.S., HAGBERG, H., the classification of KALLANDER, C.F.R. & SIMONSSON, B. The tumour cells. use of serum deoxythymidine kinase as a prognostic marker, and in the monitoring of Short Communications patients with non-Hodgkin's lymphoma. 537 KOCH, G.L.E., SMITH, M.J., GRANT, A.G. & 497 ENGELHOLM, S.A., SPANG-THOMSEN, M. HERMON-TAYLOR, J. Stability of the & VINDELOV, L.L. A short term in vitro test glycoproteins from a primary human pancreatic for tumour sensitivity to adriamycin based on carcinoma during cell culture and in vivo passage flow cytometric DNA analysis in nude mice. 541 TWENTYMAN, P.R. Exclusion of host cells Meeting Reports during spheroid formation from disaggregated solid tumours. 553 TWENTYMAN, P.R. & WORKMAN, P. Second U.K. workshop on the enhancement of 545 ITALIA, C., PAGLIA, L., TRABATTONI, A., chemotherapy by nitroimidazoles. LUCHINI, S., VILLA, F., BERETTA, L., MARELLI, G. & NATALE, N. Distribution of 555 EMBLETON, M.J. British Association for 4'epi-doxorubicin in human tissues. Cancer Research Proceedings of Joint Meeting with Section of Oncology, Royal Society of 549 MUMFORD, C.J., ELSTON, C.W., Medicine, December 1982. CAMPBELL, F.C., BLAMEY, R.W., JOHNSON, J., NICOLSON, R.I. & 575 BOOK REVIEWS GRIFFITHS, K. Tumour epithelial cellularity and quantitative oestrogen receptor 578 ANNOUNCEMENTS concentrations in primary breast cancer.

Volume 47, No. 5 May 1983

Review 671 GAUKROGER, J., WILSON, L., STEWART, M., FARID, Y., HABESHAW, T., HARDING, 589 WOODRUFF, M.F.A. Review-Cellular N. & MACKIE, R. Paradoxical response of heterogeneity in tumours. malignant melanoma to methotrexate in vivo and in vitro. Papers 681 CRAWFORD, D.H., ILIESCU, V., EDWARDS, 595 THOMPSON, C.H., JONES, S.L., PHIL, E. & A.J. & BEVERLEY, P.C.L. Characterisation of McKENZIE, I.F.C. Monoclonal antibodies to Epstein-Barr virus-specific memory T cells from human colon and colorectal carcinoma. the peripheral blood of serpositive individuals. 607 STEVENSON, F.K., SPELLERBERG, M. & 687 SHAU, H., KOREN, H.S. & DAWSON, J.R. SMITH, J.L. Monoclonal immunoglobulin light Human natural killing against ovarian carcinoma. chain in urine of patients with B lymphocytic disease: Its source and use as a diagnostic aid. 697 POOLE, A., BROWN, R.C., TURVER, C.J., SKIDMORE, J.W. & GRIFFITHS, D.M. In 613 PECKHAM, M.J., BARRETT, A., LIEW, K.H., vitro genotoxic activities of fibrous erionite. HORWICH, A., ROBINSON, B., DOBBS, H.J., McELWAIN, T.J. & HENDRY, W.F. The 707 KARZIN-STORRAR, L., FAED, M.J.W., treatment of metastatic germ-cell testicular MAcGILLIVRAY, J.B. & SMITH, P.G. tumours with bleomycin, etoposide and CIS- Incidence of familial Hodgkin's Disease. platin (BEP). Short Communications 621 HARRIS, A.L., DOWSETT, M., SMITH, I.E. & JEFFCOATE, S.L. Endocrine effects of low dose 713 STUART, A.E. The production of abnormal cells aminoglutethimide alone in advanced and Reed-Sternberg-like cells from normal postmenopausal breast cancer. lymphocytes. 629 HOWAT, J.M.T., BARNES, D.M., HARRIS, 719 LEVESON, S.H., WIGGINS, P.A., NASIRU, M. & SWINDELL, R. The association of cytosol T.A., GILES, G.R., ROBINSON, P.J. & oestrogen and progesterone receptors with PARKIN, A. Improving the detection of hepatic histological features of breast cancer and early metastases by the use of dynamic flow recurrence of disease. scintigraphy. 641 BRUNNER, N., SPANG-THOMSEN, M., 723 WILLIAMS, E.D., WAREHAM, K.A. & VINDELOV, L. & NIELSEN, A. Effect of 17,B- HOWELL, S. Direct evidence for the single cell oestradiol on growth curves and flow cytometric origin of mouse liver cell tumours. DNA distribution of two human breast 727 GRISHAM, M.B., BERNSTEIN, L.H. & carcinomas grown in nude mice. EVERSE, J. The cytoplasmic malate 649 GLEDHILL, R.M., EDWARDS, A.J. & dehydrogenase in neoplastic tissues. Presence of a NORMAN, M.R. Synergistic killing of human novel isoenzyme? leukaemic lymphoblasts by glucocorticoids and cytosine arabinoside. 733 Letter to the Editor 659 LEE, F.Y.F. & WORKMAN, P. Modification of 735 BOOK REVIEWS CCNU pharmacokinetics by misonidazole-a major mechanism of chemosensitization in mice. 741 ANNOUNCEMENTS Volume 47, No. 6 June, 1983 749 HENDERSON, B.E., CASAGRANDE, J.T., S., PASSI, S. & NAZZARO-PORRO. M. PIKE, M.C., MACK, T., ROSARIO, I. & Ultrastructural and biochemical observations on DUKE, A. The epidemiology of endometrial the effect of 4-hydroxyanisole plus tyrosinase on cancer in young women. normal human melanocytes and keratocytes in tissue culture. 757 BRINTON, L.A., HOOVER, R. & FRAUMENI, Jr. J.F. Reproductive factors in 823 LAMERZ, R. & BURTIN, P. Immunological the aetiology of breast cancer. comparison of carcino-embryonic antigen (CEA) extracted from tumours of various organs. Their 763 DOWSETT, M., McGARRICK, G.E., use in radioimmunological CEA determinations. HARRIS, A.L., COOMBES, R.C., SMITH, I.E. & JEFFCOATE, S.L. Prognostic significance of 833 REEVE, J.G. & TWENTYMAN, P.R. Clonal serum prolactin levels in advanced breast cancer. variation in the arrest, survival and growth of RIF-1 mouse sarcoma cells in the lungs of C3H 771 SAHAI SRIVASTAVA, B.I., ROSSOWSKI, W. mice. & MINOWADA, J. Cytochemical comparison of immunologically characterised human 841 REEVE, J.G., WRIGHT, K.A. & leukaemia/lymphoma cell lines representing TWENTYMAN, P.R. Response to X-radiation different levels of maturation. and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated 781 BOSANQUET, A.G., BIRD, M.C., PRICE, from RIF- I mouse sarcoma. W.J.P. & GILBY, E.D. An assessment of a short- term tumour chemosensitivity assay in chronic Short Communications lymphocytic leukaemia. 849 SHIPMAN, R., MALCOLM, A. & LEVY, J.G. 791 DENHAM, S., ATTRIDGE, S., BARFOOT, Partial characterisation of a membrane antigen R.K. & ALEXANDER, P. Effect of cyclosporin which exhibits specificity for cells of patients with A on the anti-leukaemia action associated with acute myelogenous leukaemia. graft-versus-host disease. 853 ROSS, R., DWORSKY, R., PAGANINI-HILL, 797 MOORE, K. & McBRIDE, W.H. Enhanced Fc A., BOONE, J., NICHOLS, P. & MACK, T. The receptor expression by a sub-population of occurrence of multiple lymphoreticular and murine intra-tumour macrophages following haematological malignancies in the same intravenous corynebacterium parvum therapy. households. 803 TOLIOU, T.R., GABRIELIDES, C.G., 857 ALDERSON, M.R. & CLARKE, J.A. Cancer PAPAKYRIAZIS, N. & TAYLOR- incidence in patients with psoriasis. PAPADIMITRIOU J. Decrease in mammary tumour incidence in virgin C3H mice given 861 WYNFORD-THOMAS, D., STRINGER, interferon only while suckling. B.M.J., GOMEZ MORALES, M. & WILLIAMS, E.D. Vascular changes in early 809 TISDALE, M.J. & MAHMOUD, M.B. Activities TSH-induced thyroid tumours in the rat. of free radical metabolising enzymes in tumours. 867 BOOK REVIEWS 813 BREATHNACH, A., ROBINS, E., ETHRIDGE, L., BHASIN, Y., GALLAGHER, 871 ANNOUNCEMENTS

Volume 48, No. 1 July 1983 1 MILLER, J.A. & MILLER, E.C. The 1983 17 TWENTYMAN, P.R. & WORKMAN, P. Walter Hubert Lecture-The metabolic activation Chemosensitization by lipophilic nitroimidazoles. and nucleic acid adducts of naturally-occuring 27 OVERGAARD, J., OVERGAARD, M. & carcinogens: Recent results with ethyl carbamate TIMOTHY, A.R. Studies of the pharmacokinetic and the spice flavours safrole and estragole. properties of nimorazole. Short Communications 35 CHRISTENSEN, T., SANDQUIST, T., 89 HARMER, J.H., LOLAIT, S.J., TOH, B.H., FEREN, K., WAKSVIK, H. & MOAN, J. PEDERSEN, J.S., CHAPPONIER, C. & Retention and photodynamic effects of GABBIANI, G. Actin depolymerizing factor and haematoporphyrin derivative in cells after the organisation and distribution of actin in prolonged cultivation in the presence of astrocytomas and meningiomas. porphyrin. 95 AGBOOLA, O.O., RALEIGH, J.A., 45 RAAPHORST, G.P. & AZZAM, E.I. Thermal PEDERSEN, J.E., URTASUN, R.C. & radiosensitization in Chinese hamster (V79) and BARRON, G. Dexamethasone and radiation mouse C3H lOT 1/2 cells. The thermotolerance response in the Lewis lung tumour model. effect. 99 WALKER, P.G., SINGER, A., DYSON, J.L., 55 UITENDAAL, M.P., HUBERS, H.A.J.M., SHAH, K.V., TO, A. & COLEMAN, D.V. The McVIE, J.G. & PINEDO, H.M. Human tumour prevalence of human papilloma virus antigen in clonogenicity in agar is improved by cell-free patients with cervical intraepithelial neoplasia. ascites. 103 TSAO, S.W., BURMAN, J.F. & CARTER, R.L. 61 MORASCA, L., ERBA, E., VAGHI, M., Hypercalcaemia and in vitro osteolysis associated GHELARDONI, C., MANGIONI, C., SESSA, with xenografts of squamous carcinomas of the C., LANDONI, F. & GARATTINI, S. Clinical head and neck. correlation of in vitro drug sensitivities of ovarian cancer cells. 109 VAN DOKKUM, W., DE BOER, B.C.J., VAN FAASSEN, A., PIKAAR, N.A. & HERMUS, 69 LARGE, D.M., JONES, J.M., SHALET, S.M., R.J.J. Diet, faecal pH and colorectal cancer. SCARFFE, J.H. & GIBBS, A.C.C. Gynaecomastia complicating the treatment of 111 ABSTRACTS for the 24th AGM of the BACR myeloma. March 23rd-25th, 1983. 75 POUPON, M.F., JUDDE, J.G., POT-DEPRUN, Letter to the Editor J., SWEENEY, F. & LESPINATS, G. Variable susceptibility to NK activity of cloned cell lines 149 TH. WAALER, H. & LUND, E. Associatio derived from a primary rat rhabdomyosarcoma: between body height and death from brr Relationship to metastatic potential. cancer. 83 BALLIN, A., ALADJEM, M., BANYASH, M.. 151 BOOK REVIEWS BOICHIS, H., BARZILAY, Z., GAL, R. & WITZ, I.P. The effect of Lithium Chloride in 155 ANNOUNCEMENTS tumour appearance and survival of melanoma bearing mice. 157 CALENDAR

Volume 48, No. 2 August 1983

167 BAGSHAWE, K.D. Tumour markers-where do 217 HARDELL, L. & BENGTSSON, N.O. we go from here? (Third Gordon Hamilton- Epidemiological study of socioeconomic factors Fairley Memorial Lecture-1982 BACR/RSM and clinical findings in Hodgkin's Disease and Winter Meeting). reanalysis of previous data regarding chemical 177 BRAMWELL, M.E., BHAVANANDAN, V.P., exposure. WISEMAN, G. & HARRIS, H. Structure and 227 LAWSON, A.D.G. & STEVENSON, G.T. function of the Ca antigen. Macrophages induce antibody-dependent 185 CADER, A., RICHARDSON, P., WALSH, L., cytostasis but not lysis in guinea pig leukaemic LING, N.R., MACLENNAN, I.C.M., JONES, cells. E.L. & LEYLAND, M. The incidence of B cell 239 DAVIES, G., GRANT, A.G., DUKE, D. & leukaemia and lymphopenia in B cell neoplasia in HERMON-TAYLOR, J. Antibody response of adults. A study using the Kiel classification on nude (RNU/RNU) and hairy (RNU/+) rats to non-Hodgkin's lymphoma. circulating cell surface components from human 195 KINGSTON, J.E., McELWAIN, T.J. & pancreatic cancer xenografts. MALPAS, J.S. Childhood rhabdomyosarcoma- 247 GARLAND, J.M., ALDRIDGE, A., Experience of the children's solid tumour group. WAGSTAFFE, J. & DEXTER, T.M. Studies on 209 AMLOT, P.L., SLANEY, J. & BROWN, R. the in vivo production of a lymphokine activity, Atopy-A favourable progniostic factor for Interleukin 3 (IL-3) elaborated by lymphocytes survival in Hodgkin's Disease. and a myeloid leukaemic line in vitro, and the fate of IL-3 dependent cell lines. 261 URIEL, J., POUPON, M.F. & GEUSKENS, M. 307 JORI, G., TOMIO, L., REDDI, E., ROSSI, E., Alphafetoprotein uptake by cloned cell lines CORTI, L., ZORAT, P.L. & CALZAVARA, F. derived from a nickel-induced rat rhabdomyo- Preferential delivery of liposome-incorporated sarcoma. porphyrins to neoplastic cells in tumour-bearing 271 McNALLY, N.J., HINCHLIFFE, M. & DE rats. RONDE, J. Enhancement of the action of alky- 311 HOSAKA, S., NAGAYAMA, H., HIRONO, I. lating agents by single high, or chronic low doses & HAGA, M. Enhanced activity of ornithine of misonidazole. decarboxylase of the ileum in rats by bracken 279 GRDINA, D.J., WHITE, R.A. & STRAGAND, fern (Pteridium aquilinum). J.J. Cytotoxic effects of vincristine on tumour 315 ROBINSON, B.A., COLLS, B.M. & TURNER, subpopulations separated from pulmonary J.G. Adriamycin cardiotoxicity monitoring by nodules. radionuclide scan. 289 TUDOR, R.J., SEVERS, N.J. & HICKS, R.M. The induction of urothelial hyperplasia by methyl 319 BOOK REVIEWS methanesulphonate and ethyl methanesulphonate. 322 ANNOUNCEMENTS Short Communications 323 CALENDAR

301 KNOWLES, J.F. Cancer of rat ovaries: Sertoli cell or granulosa-theca cell tumours?

Volume 48, No. 3 September 1983 329 CORNBLEET, M.A., McELWAIN, T.J., 395 PARR, I.B., JACKSON, L.E. & ALEXANDER, KUMAR, P.J., FILSHIE, J., SELBY, P., P. Role of "lymphotoxin" in the local anti- CARTER, R.L., HEDLEY, D.W., CLARK, tumour action associated with inflammation M.L. & MILLAR, J.L. Treatment of advanced caused by delayed hypersensitivity responses or malignant melanoma with high-dose melphalan intralesional BCG. Part 1. Variations in response and autologous bone marrow transplantation. of different syngeneic mouse tumours. 335 COPPACK, S., NEWLANDS, E.S., DENT, J., 405 MATTHEWS, N. Anti-tumour cytotoxin MITCHELL, H., GOKA, G. & BAGSHAWE, produced by human monocytes: Studies on its K.D. Problems of interpretation of serum concen- mode of action. trations of alpha-foetoprotein (AFP) in patients receiving cytotoxic chemotherapy for malignant 411 VILLA, M.L., MIGLIORI, M. & CLERICI, E. germ cell tumours. Antibody production in cultured blood lympho- cytes from breast cancer patients. 341 DE MELLO, J., STRUTHERS, L., TURNER, R., COOPER, E.H., GILES, G.R. & THE 417 UBEIRA, F.M., SEOANE, R., PUENTES, E., YORKSHIRE REGIONAL GASTROINTES- FARO, J. & REGUEIRO, B.J. Effect of TINAL CANCER RESEARCH GROUP. Multi- clofibrate on the growth-kinetics of the murine P variate analyses as aids to diagnosis and assess- 1798(sc) lymphoma. ment of prognosis in gastrointestinal cancer. 423 NIRMUL, D., PEGORARO, R.J., JIALAL, I., 349 FORMAN, D., DOLL, R. & PETO, R. Trends NAIDOO, C. & JOUBERT, S.M. The sex in mortality from carcinoma of the liver and the hormone profile of male patients with breast use of oral contraceptives. cancer. 355 KINLEN, L.J., HERMON, C. & SMITH, P.G. 429 DOAK, S.M.A., BROWN, V.K.H., HUNT, P.F., A proportionate study of cancer mortality among SMITH, J.D. & ROE, F.J.C. The carcinogenic members of a vegetarian society. potential of twelve refined mineral oils following long-term topical application. 363 LA VECCHIA, C., MORRIS, H.B. & DRAPER, G.J. Malignant ovarian tumours in childhood in Britain, 1962-78. Short Communications 375 HINCHLIFFE, M., McNALLY, N.J. & 437 HENDERSON, B.E., PRESTON-MARTIN, S., STRATFORD, M.R.L. The effect of radiosensi- EDMONSON, H.A., PETERS, R.L. & PIKE, tizers on the pharmacokinetics of melphalan and M.C. Hepatocellular carcinoma and oral contra- cyclophosphamide in the mouse. ceptives. 385 JOYCE, R.M. & VINCENT, P.C. Advantage of 441 BISHOP, C.J. & WHITING, V.A. The role of reduced oxygen tension in growth of human natural killer cells in intravascular death of intra- melanomas in semi-solid cultures: Quantitative venously injected murine tumour cells. analysis. 445 CLUTTERBUCK, R.D., MILLAR, J.L. & 449 BOOK REVIEWS ALEXANDER, P. Failure of high doses of a 453 ANNOUNCEMENT interferon to affect the growth of human carcinoma, melanoma and myeloid leukaemia 455 CALENDAR xenografts.

Volume 48, No. 4 October 1983 463 NYCE, J., WEINHOUSE, S. & MAGEE, P.N. 553 JONES, D.H., BLEEHEN, N.M., WORKMAN, 5-Methylcytosine depletion during tumour P. & WALTON, M.I. The role of dexamethasone development: An extension of the miscoding in the modification of misonidazole pharmaco- concept. kinetics. 477 RAINEY, J.B., DAVIES, P.W., BRISTOL, J.B. 559 LIHOU, M.G. & SMITH, P.G. Quantitation of & WILLIAMSON, R.C.N. Adaptation and chemosensitivity in acute myekocytic leukaemia. carcinogenesis in defunctioned rat colon: 569 SARGENT, N.S.E., PRICE, J.E. & TARIN, D. Divergent effects of faeces and bile acids. Effect of enzymic removal of cell surface 485 HIGGINS, P.G., DARZYNKIEWICZ, Z. & constituents on metastatic colonisation potential MELAMED, M.R. Secretion of albumin and of mouse mammary tumour cells. alphafetoprotein by dimethylsulfoxide-stimulated 579 MILANO, G., MOLL, J.L., FORMENTO, J.L., hepatocellular carcinoma cells. FRANCOUAL, M., KREBS, B.P., NAMER, 495 CURTIN, N.J. & SNELL, K. Enzymic retro- M., BOUBLIL, J.L. & LALANNE, C.M. differentiation during hepatocarcinogenesis and Simultaneous micro measurement of steroid liver regeneration in rats in vivo. receptors in breast cancer. 507 ZIEGLER-HEITBROCK, H.W.L., ERHARDT, 585 HARRIS, A.L., DOWSETT, M., SMITH, I.E. & J. & RIETHMULLER, G. Treatment of fresh JEFFCOATE, S. Aminoglutethimide induced human leukaemia cells with actinomycin D hormone suppression and response to therapy in enhances their lysability by natural killer cells. advanced postmenopausal breast cancer. 515 COLOTTA, F., RAMBALDI, A., COLOMBO, N., TABACCHI, L., INTRONA, M. & Short Communications MANTOVANI, A. Effect of a streptococcal preparation (OK432) on natural killer activity of 595 HARRIS, A.L., MITCHELL, M.D., SMITH, tumour-associated lymphoid cells in human I.E. & POWLES, T.J. Suppression of plasma 6- ovarian carcinoma and on lysis of fresh ovarian keto-prostaglandin F1, and 13,14-dihydro-15- tumour cells. keto-prostaglandin F2. by aminoglutethimide in advanced breast cancer. 527 SHABANA, A.H.M., IVANYI, L. & KRAMER, I.R.H. Expression of the CAl determinant by 599 HOLMAN, C.D.J. & ARMSTRONG, B.K. carcinomas and by non-malignant epithelial cells Hutchinson's melanotic freckle melanoma in oral lesions. associated with non-permanent hair dyqs. 533 ORMEROD, M.G., STEELE, K., 603 CAYGILL, C., DAY, D.W. & HILL, M.J. The WESTWOOD, J.H. & MAZZINI, M.N. histopathology of gastric cancer in rural and Epithelial membrane antigen: Partial purification, urban areas of North Wales. assay and properties. 607 BOOK REVIEWS 543 ROGNUM, T.O., BRADTZAEG, P. & THORUD, E. Is heterogeneous expression of 613 CALENDAR HLA-DR antigens and CEA along with DNA- profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas?

Volume 48, No. 5 November 1983 621 FRANCESCHI, S., DOLL, R., GALLWEY, J., 637 HEUCH, I., KVALE, G., JACOBSEN, B.K. & LA VECCHIA, C., PETO, R. & SPRIGGS, A.I. BJELKE, E. Use of alcohol, tobacco and coffee Genital warts and cervical neoplasia: An and risk of pancreatic cancer. epidemiological study. 645 EASTWOOD, J. & BAKER, T.G. Cutaneous 629 PETERS, R.K. & MACK, T.M. Patterns of anal malignant melanoma in West Yorkshire: I. A carcinoma by gender and marital status in Los prospective study of variables, survival and Angeles county. prognosis. 657 AHMEDZAI, S., CARLYLE, D.L., CALDER, 717 UDAYACHANDER, M., MEENAKSHI, A., I.T. & MORAN, F. Anti-emetic efficacy and ANSAMMA, J. & MUTHIAH, R. Lymphoma toxicity of nabilone, a synthetic cannabinoid, in associated antigen (LAA): Isolation, lung cancer chemotherapy. characterisation and clinical evaluation. 665 GLAVES, D. Correlation between circulating 727 WAGNER, M.M.F., DARKE, C., COLES, cancer cells and incidence of metastases. R.M. & EVANS, C.C. HLA-A and B antigen frequencies and mesothelioma in relation to 675 HAMBURGER, A.W., WHITE, C.P. & DUNN, asbestos exposure. F.E. Modulation of tumour colony growth by irradiated accessory cells. 731 MORRIS, A.J.R., O'SULLIVAN, J.P., MILLARD, F.J.C., HUMBERSTONE, A.M., 683 CALVO, F., CARNEY, D.N., BROWER, M. & HUNT, J., GAZET, J.C., POWLES, T.J., MINNA, J.D. Hormone supplemented media for FORD, H.T. & COOMBES, R.C. Fibreoptic cloning human breast cancer: Increased colony bronchoscopy as an aid to diagnosis of formation without alteration of chemosensitivity. respiratory symptoms in breast cancer patients. 689 KARMALI, R.A., WELT, S., THALER, H.T. & 735 FOA, P., COFRANCESCO, E., LOMBARDI, LEFEVRE, F. Prostaglandins in breast cancer: L., COLOMBI, M., POGLIANI, E.M. & Relationship to disease stage and hormone status. POLLI, E.E. Non interference by Leporin with the cytostatic effect of adriamycin: An in vitro 697 TSAO, S.W., BURMAN, J.F., PITTAM, M.R. study on a human promyelocytic leikaemia cell & CARTER, R.L. Further observations on line. mechanisms of bone destruction by squamous 739 J.A. & carcinomas of the head and DOUBLE, BIBBY, M.C. Characterization neck. and chemosensitivity of a well-differentiated 705 McDERMOTT, B.J., VAN DEN BERG, H.W., murine transplantable adenocarcinoma of the MARTIN, W.M.C. & MURPHY, R.F. Pharma- coloil. cokinetic rationale for the interaction of 5- fluorouracil and misonidazole in humans. 74.3 BOOK REVIEW'S 711 BRAAKHUIS, B.J.M., SCHOEVERS, E.J., 747 CALENDAR HEINERMAN, E.C.M., SNEEUWLOPER, G. & SNOW, G.B. Chemotherapy of human head and neck cancer xenografts with three clinically active drugs: cis-platinum, bleomycin and metho- trexate.

Volume 48, No. 6 December 1983 755 MRC LUNG CANCER WORKING PARTY. 797 KELLY, G.E. & SHEIL, A.G.R. Sister chromatid Cytotoxic chemotherapy before and after exchange in lymphocytes from renal transplant radiotherapy compared with radiotherapy recipients with and without cancer. followed by chemotherapy in the treatment of 803 small-cell carcinoma of the bronchus: The results BOCIAN, E., LAVERICK, M. & NIAS, A.H.W. up to 36 months. Sister chromatid exchanges induced by two radio- sensitizing platinum compounds (cis-dichloro-bis 763 CHILOSI, M., PIZZOLO, G., FIORE-DONATI, isopropylamine trans dihydroxy platinum IV L., BOFILL, M. & JANOSSY, G. Routine (CHIP)andcis-platinummetronidazole2 (FLAP))in immunofluorescent and histochemical analysis CHO cells in vitro. of bone marrow involvement of 809 PETTERSON, E.O. & LINDMO, T. Inhibition of lymphoma/leukaemia: The use of cryostat sections. cell-cycle progression by acute treatment with 777 GALLAGHER, C.J., KNOWLES, G.K., various degrees of hypoxia: Modifications induced HABESHAW, J.A., GREEN, M., MALPAS, J.S. & by low concentrations of misonidazole present LISTER, T.A. Early involvement of the bronchi in during hypoxia. patients with malignant lymphoma. 819 BRADLEY, N.J., DARLING, J.L., OKTAR, N., 783 SOMASUNDARAM, R., ADVANI, S.H. & BLOOM, H.J.G., THOMAS, D.G.T. & DAVIES, GANGAL, S.G. Concanavalin A induced A.J.S. The failure of human leucocyte interferon to suppressor cell activity and autorosette forming cells influence the growth of human glioma cell in chronic myeloid leukaemia patients. populations: In vitro and in vivo studies. 791 IQBAL, M. JAWED, WILKINSON, M.L., 827 SUZUKI, N. Variant selection and blood-borne JOHNSON, P.J. & WILLIAMS, R. Sex steroid "clonogenic" tumour cells in metastasis of FSA cell receptor proteins in foetal adult and malignant clones. human liver tissue. 835 STILLER, C.A. & LENNOX, E.L. Childhood 869 KANOJIA, M., KANTARJIAN, H., AJANI, J. & medulloblastoma in Britain 1971-77: Analysis of BARLOGIE, B. High-dose cytosine arabinoside treatment and survival. (ARA-C) in colorectal cancer. 843 LEE, F.I. Screeningforcolorectalcancerina factory- 873 NOBBS, P. & BARR, R.D. Soft-tissue injury caused based population with fecatest. by anti-neoplastic drugs is inhibited by topical dimethyl sulphoxide and alpha tocopherol. Short Communications 877 GORE, M.E., SKILTON, R.A. &COOMBES, R.C. 849 KNOX, E.G., STEWART, A.M. & KNEALE, Antibody-dependent-cellular-cytotoxicity against G.W. Foetal infection, childhood leukaemia and cultured human breast cancer cells mediated by cancer. human effector cells using monoclonal and 853 GALLAGHER, R.P., SPINELLI, J.J., ELWOOD, polyclonal antibodies. J.M. & SKIPPEN, D.H. Allergies and agricultural 881 SAPPINO, A.P., CARTER, S., ELLISON, M. & exposure as risk factors for multiple myeloma. SMITH, I.E. Plasma calcitonin in small cell lung 859 McCORMICK, D.L. & MOON, R.C. Inhibition of cancer: Prognostic implications. mammary carcinogenesis by fluribiprofen, a non- steroidal antiinflammatory agent. 883 BOOKS RECEIVED 863 MEYSKENS, JR., F.L., THOMSEN, S.P., 885 CALENDAR HICKIE, R.A. & SIPES, N.J. Potential biological explanation ofstimulation ofcolony growth in semi- solid agar by cytotoxic agents.

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The British Journal of Cancer is published monthly on behalf of the Cancer Research Campaign by the Scientific and Medical Division, The Macmillan Press Ltd, Houndsmills, Basingstoke, Hampshire RG21 2XS. All rights of reproduction are reserved. ©) 1984 Cancer Research Campaign. ISSN 0007-0920