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Cumulative Contents, 1983 Volume 47, No.1 January 1983 I STEEL, G.G., COURTENAY, V.D. & OXFORD LYMPHOMA GROUP. Prognostic PECKHAM, M.J. The response to chemotherapy factors in non-Hodgkins lymphoma: The of a variety of human tumour xenografts. importance of symptomatic stage as an adjunct to the Kiel histopathological classification. 15 STRUCK, R.F., DYKES, D.J., CORBETT, T.H., SULING, W.J. & TRADER, M.W. 103 TRENT, J.M., DAVIS, J.R. & DURIE, B.G.M. Isophosphoramide mustard, a metabolite of Cytogenetic analysis of leukaemic colonies from ifosfamide with activity against murine tumours acute and chronic myelogenous leukaemia. comparable to cyclophosphamide. Ill CHILD, J.A., CRAWFORD, S.M., NORFOLK, 27 MUINDI, J.R.F., NEWELL, D.R., SMITH, I.E. D.R., O'QUIGLEY, J., SCARFFE, J.H. & & HARRAP, K.R. Pentamethylmelamine STRUTHERS, L.P.L. Evaluation of serum beta (PMM): Phase I clinical and pharmacokinetic 2-microglobulin as a prognostic indicator in studies. myelomatosis. 35 FORD, C.H.J., NEWMAN, C.E., JOHNSON, 115 EL-DEEB, B.B., BURNS, S., ROBINSON, R., J.R., WOODHOUSE, C.S., ROWLAND, G.F., HAMMOND, E.M. & MANN, J.R. Serum SIMMONDS, R.G. & REEDER, T.A. dopamine-,B-hydroxylase in children with Localisation and toxicity study of a vindesine neuroblastoma. anti-CEA conjugate in patients with advanced cancer. 123 BINDON, C., CZERNIECKI, M., RUELL, P.. EDWARDS, A., McCARTHY, W.H.. 43 EMBLETON, M.J., ROWLAND, G.F., HARRIS, R. & HERSEY, P. Clearance of rates SIMMONDS, R.G., JACOBS, E., MARSDEN, and systematic effects of intravenously C.H. & BALDWIN, R.W. Selective cytotoxicity administered Interleukin 2 (IL2) containing against human tumour cells by a vindesine- preparations in human subjects. monoclonal antibody conjugate. 135 SIKORA, K., ALDERSON, T. & ELLIS, J. 51 BEN-HUR, E., SHAW, J.J. & BLEEHEN, N.M. Human hybridomas from patients with malignant Enhancement of thermal killing by polyamines V. disease. The response of EMT6 multicellular tumour spheroids versus monolayer cells. 147 VAN DE LINDE, A.W., STREEFKERK, M., SCHUURMAN, H.J., TE VELDE, E.R. & 57 TWENTYMAN, P.R. Modification by WR 2721 KATER, L. Divergence between the occurrence of the response to chemotherapy of tumours and of antibody and cellular immune reactivity to normal tissues in the mouse. cervical carcinoma cell lines in preinvasive and macroinvasive stages of cervical carcinoma. 65 ROJAS, A., STEWART, F.A. & DENEKAMP, J. Interaction of misonidazole and WR-2721. 2. 155 ASTOR, M.B., PARHAM, J.C., HALL, E.J., Modification of tumour radiosensitization. TEMPLETON, M.A. & HARTOG, B. A 3-nitro triazole as a hypoxic cell sensitizer. 73 ANDO, K., PETERS, L.J., HUNTER, N., JINNOUCHI, K. & MATSUMOTO, T. 158 ROSSOWSKI, W. & SAHAI SRIVASTAVA, Inhibition of artificial and spontaneous lung B.I. Ectosialyltransferase activity: a marker for metastases by preirradiation of abdomen II. certain human haematopoietic cells. Target organ and mechanism. 161 WALKER, L.C., TUCKER, D.F. & BEGENT, 81 WEISS, L., HOLMES, J.C. & WARD, P.M. Do R.H.J. Identification of PEG-precipitable serum metastases arise from pre-existing subpopulations factor associated with malignant lymphoma as C- of cancer cells? reactive protein. 91 LEONARD, R.C.F., CUZICK, J., 165 BOOK REVIEWS MACLENNAN, I.C.M., VANHEGAN, R.I., MACKIE, P.H., McCORMICK, C.V. & 167 ANNOUNCEMENTS Volume 47, No. 2 February 1983 175 IJIRI, K. & POTTEN, C.S. Response of 269 SECRETO, G., RECCHIONE, C., intestinal cells of differing topographical and CAVALLERI, A., MIRAGLIA, M. & DATI, V. hierarchical status to ten cytotoxic drugs and five Circulating levels of testosterone, 17f,-oestradiol sources of radiation. luteinising hormone and prolactin in postmenopausal breast cancer 187 TWENTYMAN, P.R. & WORKMAN, P. An patients. investigation of the possibility of 277 TOMLEY, F.M., ARMSTRONG, S.J., MAHY, chemosensitization by clinically achievable B.W.J. & OWEN, L.N. Reverse transcriptase concentrations of misonidazole. activity and particles of retroviral density in cultured canine lymphosarcoma supernatants. 195 MURRAY, D. & MEYN, R.E. Enhancement of the DNA cross-linking activity of melphalan by 285 MOLE, R.H., PAPWORTH, D.G. & CORP, misonidazole in vivo. M.J. The dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice. 205 MORGAN, D., FRESHNEY, R.I., DARLING, J.L., THOMAS, D.G.T. & CELIK, F. Assay of 293 TISDALE, M.J. & BRENNAN, R.A. Loss of anticancer drugs in tissue culture: cell cultures of acetoacetate coenzyme A transferase activity in biopsies from human astrocytoma. tumours of peripheral tissues. 215 EVANS, B.D., SMITH, I.E. & MILLAR, J.L. High dose cyclophosphamide treatment of human oat cell xenografts in immune deprived mice. Short Communications 221 SILVESTRINI, B., HAHN, G.M., CIOLI, V. & 299 MORIYAMA, S., KAWAOI, A. & HIROTA, N. DE MARTINO, C. Effects of lonidamine alone Gamma-glutamyl transpeptidase in putative or combined with hyperthermia in some precancerous thyroid lesions of rats treated with experimental cell and tumour systems. diisopropanolnitrosamine. 303 PINKERTON, C.R. Is folate absorption 233 HASTINGS, R.J. & FRANKS, L.M. Cellular impaired by high dose methotrexate? heterogeneity in a tissue culture cell line derived from a human bladder carcinoma. 307 MCCLUSKEY, D.R., ROY, A.D., ABRAM, W.P. & MARTIN, W.M.C. T lymphocyte subsets 245 KERR, K.M., ROBERTSON, A.M.G. & in the peripheral blood of patients with benign LAMB, D. In vitro thymidine labelling of human and malignant breast disease. pulmonary neoplasms. 311 SWERDLOW, A.J. Epidemiology of melanoma 253 SMEDLEY, H.M., FINAN, P., LENNOX, E.S., of the eye in the Oxford region, 1952-1978. RITSON, A., SIKORA, K. TAKEI, F. & WRAIGHT, P. Localisation of metastatic carcinoma by a radio-labelled monoclonal Letter to the Editor antibody. 315 KAY, H.E.M. Planning and comparisons in 261 CASTAGNETTA, L., LO CASTO, M., clinical trials. MERCADANTE, T., POLITO, L., COWAN, S. & LEAKE, R.E. Intra-tumoural variation of 319 BOOK REVIEWS oestrogen receptor status in endometrial cancer. 323 ANNOUNCEMENTS Volume 47, No.3 March 1983 327 HABESHAW, J.A., BAILEY, D., STANSFELD, 361 JONES, D.H., BLEEHEN, N.M., SLATER, A.G. & GREAVES, M.F. The cellular content of A.J., GEORGE, P.J.M., WALKER, J.R. & non Hodgkin lymphomas: Comprehensive analysis DIXON, A.K. Human lymphoblastoid interferon using monoclonal antibodies and other surface in the treatment of small cell lung cancer. marker techniques. 367 BURTIN, C., NOIROT, C., PAUPE, J. & 353 TESTORELLI, C., CANTI, G., FRANCO, P., SCHEINMANN, P. Decreased blood histamine GOLDIN, A. & NICOLIN, A. Serotherapy of levels in patients with solid malignant tumours. L 1210 murine leukaemia-reasons for ineffectiveness of in vivo treatment by L. 1 monoclonal antibody. Short Communications 373 BRATTAIN, M.G., MARKS, M.E., 419 ROHATINER, A.Z.S., PRIOR, P.F., BURTON, McCOMBS, J., FINELY, W. & BRATTAIN, A.L., SMITH, A.T., BALKWILL, F.R. & D.E. Characterisation of human colon carcinoma LISTER, T.A. Central nervous system toxicity of cell lines isolated from a single primary tumour. interferon. 383 BIGGAR, R.J., CURTIS, R.E., HOFFMAN, D. 423 JEHN, U., KERN, D., WACHHOLZ, K. & & FLANNERY, J.T. Second primary HOLZEL, D. Prognostic value of in vitro growth malignancies following salivary gland cancers. pattern of colony forming cells in adult acute leukaemia. 387 DURAND, R.E. Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its 429 MILLER, W.R., STURGEON, C.M. & mechanism of action. WALKER, R.A. Carcinoembryonic antigen (CEA) in explants of human breast cancer: 393 PHEASANT, A.E., BATES, J., BLAIR, J.A. & Comparison of immunohistochemical detection NAYYIR-MAZHIR, R. Investigations of tissue and release short-term culture. folates in normal and malignant tissues. during 433 MORRIS, I.D. & STEPHEN, T.M. In vitro and 399 SIDEBOTTOM, E. & CLARK, S.R. Cell fusion in vivo interactions of methotrexate and other segregates progressive growth from metastases. antimetabolites with the oestrogen high affinity 407 OOSTERHUIS, J.W., BAGASRA, O., receptors of the rat uterus. KUSHNER, H., FOX, N. & DAMJANOV, I. 439 TERASIMA, T., YASUKAWA, M. & The effects of regional factors on the growth rate KIMURA, M. Development of insusceptibility to and the differentiation of mouse teratocarcinoma. serum factor during the radiation transformation 413 PRIME, S.S., MACDONALD, D.G. & RENNIE, process. J.S. The effect of iron deficiency on experimental 443 BOOK REVIEWS oral carcinogenesis in the rat. 447 ANNOUNCEMENTS Volume 47, No. 4 April 1983 455 VESSEY, M., BARON, J., DOLL, R., 503 BOCIAN, E., LAVERICK, M. & NIAS, A.H.W. McPHERSON, K. & YEATES, D. Oral The mode of action of cis-dichloro-bis contraceptives and breast cancer: Final report of (isopropylamine) trans dihydroxy platinum IV- an epidemiological study. (CHIP) studied by the analysis of chromosome 463 DURBEC, J.P., CHEVILLOTTE, G., BIDART, aberration production. J.M., BERTHEZENE, P. & SARLES, H. Diet, 511 HARLAND, R.N.L., BARNES, D.M., alcohol, tobacco and risk of cancer of the pancreas: A HOWELL, A., RIBEIRO, G.G., TAYLOR, J. & case-control study. SELLWOOD, R.A. Variation of receptor status 471 VAN STEENSEL-MOLL, H.A., in cancer of the breast. VALKENBURG, H.A. & VAN ZANEN, G.E. Incidence of childhood leukaemia in the 517 BARBASON, H., RASSENFOSSE, C. & BETZ, Netherlands (1973-1980). E.H. Promotion mechanism of phenobarbitol and partial hepatectomy in DENA hepato- 477 BLEWITT, R.W., ABBOTT, A.C. & BIRD, C.C. carcinogenesis cell kinetics effect. Mode of cell death induced in human lymphoid cells by high and low doses of glucocorticoid. 527 KOCH, G.L.E. & SMITH, M.J. Concanavalin A 487 acceptor glycoproteins: A new type of marker for GRONOWITZ, J.S., HAGBERG, H., the classification of KALLANDER, C.F.R. & SIMONSSON, B. The tumour cells. use of serum deoxythymidine kinase as a prognostic marker, and in the monitoring of Short Communications patients with non-Hodgkin's lymphoma.
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  • The Novel Dual PI3K/Mtor Inhibitor GDC-0941 Synergizes with the MEK Inhibitor U0126 in Non-Small Cell Lung Cancer Cells

    The Novel Dual PI3K/Mtor Inhibitor GDC-0941 Synergizes with the MEK Inhibitor U0126 in Non-Small Cell Lung Cancer Cells

    MOLECULAR MEDICINE REPORTS 5: 503-508, 2012 The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells ZU-QUAN ZOU1*, LI-NA ZHANG1*, FENG WANG2, JÉRÔME BELLENGER3, YIN-ZHUO SHEN1 and XIAO-HONG ZHANG1 1Medical School, Ningbo University; 2Clinical Laboratory, Lihuili Hospital, Ningbo 315211, P.R. China; 3UMR 866 Physiopathologie des Dyslipidémies, Faculté des Sciences Gabriel, Université de Bourgogne, Dijon, France Received May 25, 2011; Accepted August 22, 2011 DOI: 10.3892/mmr.2011.682 Abstract. Lung cancer is a malignant disease with poor outcome, witnessed targeted therapy in NSCLC. However, gefitinib, a which has led to a search for new therapeutics. The PI3K/Akt/ specific inhibitor of epidermal growth factor receptor (EGFR) mTOR and Ras/raf/Erk pathways are key regulators of tumor tyrosine kinase, has shown efficacy only in a subgroup of growth and survival. In the present study, their roles were NSCLC patients with EGFR mutations and overexpression. It evaluated by MTT assay, flow cytometry and Western blotting was previously shown that EGFR-independent activation of the in lung cancer cells. We found that a high efficacy of antitumor PI3K/Akt/mammalian target of rapamycin (mTOR) and Ras/ activity was shown with GDC-0941 treatment in two gefitinib- raf/Erk pathways may contribute to the unfavorable treatment resistant non-small cell lung cancer (NSCLC) cell lines, A549 outcome of gefitinib (2). and H460. In addition, H460 cells with activating mutations The PI3K/Akt/mTOR and Ras/raf/Erk signaling pathways of PIK3CA were relatively more sensitive to GDC-0941 than play a key role in cell growth, proliferation and survival in a A549 cells with wild-type PIK3CA.
  • Phase I Pharmacokinetic and Pharmacodynamic Study of 17

    Phase I Pharmacokinetic and Pharmacodynamic Study of 17

    VOLUME 23 ⅐ NUMBER 18 ⅐ JUNE 20 2005 JOURNAL OF CLINICAL ONCOLOGY ORIGINAL REPORT Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies Udai Banerji, Anne O’Donnell, Michelle Scurr, Simon Pacey, Sarah Stapleton, Yasmin Asad, Laura Simmons, Alison Maloney, Florence Raynaud, Maeli Campbell, Michael Walton, Sunil Lakhani, Stanley Kaye, Paul Workman, and Ian Judson From the Cancer Research UK Centre for Cancer Therapeutics, The Institute ABSTRACT of Cancer Research; Section of Medi- cine, The Institute of Cancer Research; Purpose The Royal Marsden Hospital, Sutton; To study the toxicity and pharmacokinetic-pharmacodynamic profile of 17-allylamino, 17- Cancer Research UK, Drug Development demethoxygeldanamycin (17-AAG) and to recommend a dose for phase II trials. Office; and Breakthrough Breast Cancer Research Centre, Institute of Cancer Patients and Methods Research, London, United Kingdom. This was a phase I study examining a once-weekly dosing schedule of 17-AAG. Thirty patients with advanced malignancies were treated. Submitted November 30, 2004; accepted January 18, 2005. Results 2 Supported by Cancer Research UK. The highest dose level reached was 450 mg/m /week. The dose-limiting toxicities (DLTs) encountered were grade 3 diarrhea in three patients (one at 320 mg/m2/week and two at 450 Presented in part at the 37th Annual 2 2 Meeting of the American Society of mg/m /week) and grade 3 to 4 hepatotoxicity (AST/ALT) in one patient at 450 mg/m /week. Clinical Oncology, San Francisco, CA, Two of nine DLTs were at the highest dose level. Two patients with metastatic melanoma May 12-15, 2001; 39th Annual Meeting had stable disease and were treated for 15 and 41 months, respectively.