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Weill Cornell Medical College PRSRT STD Department of Pathology and U.S. POSTAGE Laboratory Medicine PAID 525 East 68th Street, Box 69 NEW YORK, NY New York, NY 10065 PERMIT NO. 9313 Weill Cornell Hematopathology Comprehensive Diagnosticand Consultation Service Excellence inAcademic te eamn D PhD MD, Ethel Cesarman, te eamn D PhD MD, Ethel Cesarman, ailM nwe,MD Knowles, Daniel M. ailM nwe,MD Knowles, Daniel M. .Ln ag D PhD MD, Lynn Wang, Y. .Ln ag D PhD MD, Lynn Wang, Y. Hematopathology an a,M,PhD MD, Wayne Tam, an a,M,PhD MD, Wayne Tam, ua ahw PhD Susan Mathew, oa rks,MD Sonam Prakash, ua ahw PhD Susan Mathew, oa rks,MD Sonam Prakash, ct l,M,MPH MD, Ely, Scott ct l,M,MPH MD, Ely, Scott and Diagnostic tii rz,MD Attilio Orazi, tii rz,MD Attilio Orazi, ui ee,MD Julia Geyer, ui ee,MD Julia Geyer, Weill Cornell Hematopathology Services Medical and Scientific Faculty Comprehensive Diagnostic and Consultation Service The Hematopathology Consultation Report Attilio Orazi, MD, FRCPath The report includes all diagnostic information. Professor and Vice Chairman for Hematopathology Excellence in Academic and On a case-by-case basis, it may include: Weill Cornell Medical College Diagnostic Hematopathology Morphology Director, Division of Hematopathology Department of Pathology and A concise morphologic synopsis of any relevant findings, such Weill Cornell Hematopathology Comprehensive Diagnostic Laboratory Medicine as a manual differential count, is included in each report. and Consultation Service, with an internationally recognized NewYork-Presbyterian Hospital faculty, offers physicians an unsurpassed level of expertise, Immunohistochemistry Dr. Attilio Orazi is an internationally renowned academic state-of-the-art scientific analysis and personal attention. More than 300 IHC stains, including all those that are hematopathologist expertly qualified to consult in all areas Guided by the vision and leadership of Dr. Attilio Orazi, the necessary for diagnosis and prognosis. of hematopathology with an emphasis in bone marrow. He Service offers referring physicians the speed and accuracy of Flow Cytometry has published more than 150 papers, numerous textbook results required to best assist their patients. Multi-color flow cytometric analysis for lymphomas, chapters and review articles and has co-authored three major leukemias and multiple myeloma. textbooks. Dr. Orazi is listed in New York Magazine’s Best The Service provides a single, comprehensive hematopathology Doctors in New York City; Castle Connolly's Top Doctors: New consultation report containing detailed diagnostic and prognostic Manual or Computer Image Analysis for Myeloma York Metro Area, America's Top Doctors, America's Top Doctors information. For patients with multiple samples, a systematic Proliferation Index for Cancer; Best Doctors in America; Who’s Who in America comparative evaluation is used to address issues such as disease Two-color IHC to exclude non-myeloma cells from the and Who’s Who in Medicine. progression as well as response to therapy. When seeking a analysis and provide a myeloma cell-specific proliferation index. This service is routinely performed on all multiple second opinion, you are provided with a clear evidence-based Faculty interpretation which takes into consideration the clinical myeloma specimens. Front l-r: Attilio Orazi, MD presentation and the disease history. This approach is important Molecular Pathology Daniel M. Knowles, MD in neoplastic pathology of lymph node, bone marrow or spleen Molecular assays, as needed on a case-by-case basis: Wayne Tam, MD, PhD in view of the complicated diagnostic algorithms necessary to Sonam Prakash, MD ◗ Lymphoma Back l-r: Scott Ely, MD MPH apply the current WHO (2008) classification, e.g., for cases of • Immunoglobulin heavy chain gene rearrangement for Julia Geyer, MD organ-based lymphomas, lymphoma in immunocompromised B cell clonality Y. Lynn Wang, MD, PhD patients or in many myeloid neoplasms. Telephone consulta- • Immunoglobulin light chain gene rearrangement as a Not pictured: tions are encouraged. A dialogue with the clinician may even Ethel Cesarman, MD, PhD second tier test for B cell clonality be necessary to reach a comprehensive interpretation and Susan Mathew, PhD • BCL2-IGH analysis to detect a t(14;18), as is typically to understand the full implications of the diagnosis. found in follicular lymphoma Hematopathology Faculty Referring physicians and their patients benefit from: • T cell receptor gene rearrangement for T cell clonality Daniel M. Knowles, MD is an internationally recognized ➤ Consultation and case review by international • BCR-ABL analysis, p190, to detect the Philadelphia hematopathologist with special expertise in the morphologic, experts in hematopathology—difficult cases chromosome in ALL immunologic and molecular pathologic diagnosis of are discussed in a consensus conference. ◗ Plasma cell neoplasms (myeloma, amyloidosis, MGUS) hematologic malignancies. He has been listed in Who's Who in America, Who's Who in Medicine, Best Doctors in New York City, Clients benefit from the expertise of five • Immunoglobulin light chain gene rearrangement Super Doctors®, Best Doctors in New York Metropolitan Area, hematopathologists without incurring for plasma cell clonality additional fees. Top Doctors for Cancer and Best Doctors in America. ◗ Myeloid Disorders ➤ State-of-the-art flow cytometry, immunohisto- Scott Ely, MD, MPH is an expert hematopathologist • BCR-ABL analysis by RT-PCR, p210, to chemistry and molecular laboratories. with particular expertise in plasma cell diseases. detect the Philadelphia chromosome in CML ➤ Wayne Tam, MD, PhD is an expert hematopathologist Efficient personal attention and timely reporting. • Quantitative BCR-ABL analysis to track with particular expertise in malignant lymphoma. ➤ Specimen transport-Federal Express and messenger treatment efficacy in CML service at no cost to the physician or patient. • PML-RAR analysis by RT PCR to detect t(15;17) in acute Sonam Prakash, MD is an expert general hematopathologist. For consultation cases, all tissue block(s) and original promyelocytic leukemia Julia Geyer, MD is an expert general hematopathologist. slides are promptly returned. • JAK2 genotyping for diagnosis of myeloproliferative disorders Molecular Pathology Faculty ➤ Our hematopathologists have ◗ Virus Detection Ethel Cesarman, MD, PhD is an internationally recognized consistently been recognized in New • EBV PCR • HTLV1 PCR • KSHV (HHV8) PCR molecular biologist with special expertise in hematopathology. York Magazine’s Best Doctors in FISH Y. Lynn Wang, MD, PhD is a nationally recognized expert in New York, Castle Connolly’s renowned Comprehensive FISH services, including chromosomal molecular hematopathology. America’s Top Doctors—New York abnormalities required for WHO subtyping. Susan Mathew, PhD is a nationally recognized expert in Metro Area edition and in the Cytogenetics classical cytogenetics and molecular cytogenetics. Super Doctors list published in Cytogenetic analysis—widely regarded as the most thorough All faculty are board certified in anatomic pathology, clinical The New York Times Magazine. analysis available. pathology, hematology and/or molecular genetic pathology.