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Pharmacokinetic Interactions Between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance
life Review Pharmacokinetic Interactions between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance Laura Rombolà 1 , Damiana Scuteri 1,2 , Straface Marilisa 1, Chizuko Watanabe 3, Luigi Antonio Morrone 1, Giacinto Bagetta 1,2,* and Maria Tiziana Corasaniti 4 1 Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy; [email protected] (L.R.); [email protected] (D.S.); [email protected] (S.M.); [email protected] (L.A.M.) 2 Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy 3 Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 981-8558 Sendai, Japan; [email protected] 4 School of Hospital Pharmacy, University “Magna Graecia” of Catanzaro and Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-0984-493462 Received: 28 May 2020; Accepted: 30 June 2020; Published: 4 July 2020 Abstract: The therapeutic efficacy of a drug or its unexpected unwanted side effects may depend on the concurrent use of a medicinal plant. In particular, constituents in the medicinal plant extracts may influence drug bioavailability, metabolism and half-life, leading to drug toxicity or failure to obtain a therapeutic response. This narrative review focuses on clinical studies improving knowledge on the ability of selected herbal medicines to influence the pharmacokinetics of co-administered drugs. Moreover, in vitro studies are useful to anticipate potential herbal medicine-drug interactions. -
Pinoresinol Reductase 1 Impacts Lignin Distribution During Secondary Cell Wall Biosynthesis in Arabidopsis
Phytochemistry xxx (2014) xxx–xxx Contents lists available at ScienceDirect Phytochemistry journal homepage: www.elsevier.com/locate/phytochem Pinoresinol reductase 1 impacts lignin distribution during secondary cell wall biosynthesis in Arabidopsis Qiao Zhao a, Yining Zeng b,e, Yanbin Yin c, Yunqiao Pu d,e, Lisa A. Jackson a,e, Nancy L. Engle e,f, Madhavi Z. Martin e,f, Timothy J. Tschaplinski e,f, Shi-You Ding b,e, Arthur J. Ragauskas d,e, ⇑ Richard A. Dixon a,e,g, a Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA b Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA c Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA d Institute of Paper Science and Technology, Georgia Institute of Technology, Atlanta, GA, USA e BioEnergy Science Center (BESC), Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA f Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA g Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA article info abstract Article history: Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (À)-pinoresinol to (À)-lariciresinol in Available online xxxx Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas PrR2 expression is barely detect- Keywords: able in stems. Co-expression analysis has indicated that PrR1 is co-expressed with many characterized Lignan genes involved in secondary cell wall biosynthesis, whereas PrR2 expression clusters with a different Lignin set of genes. -
Memorandum Date: June 6, 2014
DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service Food and Drug Administration Memorandum Date: June 6, 2014 From: Bisphenol A (BPA) Joint Emerging Science Working Group Smita Baid Abraham, M.D. ∂, M. M. Cecilia Aguila, D.V.M. ⌂, Steven Anderson, Ph.D., M.P.P.€* , Jason Aungst, Ph.D.£*, John Bowyer, Ph.D. ∞, Ronald P Brown, M.S., D.A.B.T.¥, Karim A. Calis, Pharm.D., M.P.H. ∂, Luísa Camacho, Ph.D. ∞, Jamie Carpenter, Ph.D.¥, William H. Chong, M.D. ∂, Chrissy J Cochran, Ph.D.¥, Barry Delclos, Ph.D.∞, Daniel Doerge, Ph.D.∞, Dongyi (Tony) Du, M.D., Ph.D. ¥, Sherry Ferguson, Ph.D.∞, Jeffrey Fisher, Ph.D.∞, Suzanne Fitzpatrick, Ph.D. D.A.B.T. £, Qian Graves, Ph.D.£, Yan Gu, Ph.D.£, Ji Guo, Ph.D.¥, Deborah Hansen, Ph.D. ∞, Laura Hungerford, D.V.M., Ph.D.⌂, Nathan S Ivey, Ph.D. ¥, Abigail C Jacobs, Ph.D.∂, Elizabeth Katz, Ph.D. ¥, Hyon Kwon, Pharm.D. ∂, Ifthekar Mahmood, Ph.D. ∂, Leslie McKinney, Ph.D.∂, Robert Mitkus, Ph.D., D.A.B.T.€, Gregory Noonan, Ph.D. £, Allison O’Neill, M.A. ¥, Penelope Rice, Ph.D., D.A.B.T. £, Mary Shackelford, Ph.D. £, Evi Struble, Ph.D.€, Yelizaveta Torosyan, Ph.D. ¥, Beverly Wolpert, Ph.D.£, Hong Yang, Ph.D.€, Lisa B Yanoff, M.D.∂ *Co-Chair, € Center for Biologics Evaluation & Research, £ Center for Food Safety and Applied Nutrition, ∂ Center for Drug Evaluation and Research, ¥ Center for Devices and Radiological Health, ∞ National Center for Toxicological Research, ⌂ Center for Veterinary Medicine Subject: 2014 Updated Review of Literature and Data on Bisphenol A (CAS RN 80-05-7) To: FDA Chemical and Environmental Science Council (CESC) Office of the Commissioner Attn: Stephen M. -
Medicinal Properties of Selected Asparagus Species: a Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele
Chapter Medicinal Properties of Selected Asparagus Species: A Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele Abstract Asparagus species are naturally distributed along Asia, Africa, and Europe and are known to have numerous biological properties. This review article was aimed to provide an organized summary of current studies on the traditional uses, phy- tochemistry, and pharmacological and toxicological studies of Asparagus laricinus Burch., Asparagus africanus Lam., Asparagus officinalis L., Asparagus racemosus Willd., and Asparagus densiflorus (Kunth) Jessop to attain and establish new insights for further researches. Information used in this review was obtained from electronic database including PubMed central, Google scholars, Science direct, Scopus, and Sabinet. Based on the present findings, the existing literature still presents some breaches about the mechanism of action of various constituents of these plants, and their relation to other plant compounds in poly-herbal formulations, as well as their long-term use and safety. More in-depth studies are still needed for active compounds and biological activities of Asparagus laricinus, Asparagus africanus, and Asparagus densiflorus. Therefore, innumerable opportunities and possibilities for investigation are still available in novel areas of these plants for future research stud¬ies. It can be concluded that all selected Asparagus species have tremendous potential to improve human health and the pharmacological activities of these plants can be attributed to bioactive phytochemicals they possess. Keywords: Asparagaceae, Asparagus africanus lam., Asparagus densiflorus (kunth) Jessop, Asparagus laricinus Burch., Asparagus officinalis L., Asparagus racemosus Willd., pharmacological actions, phytochemistry 1. Introduction Historically, plants were used for numerous purposes for mankind in general, inter alia, feeding and catering, culinary spices, medicine, various forms of cosmetics, symbols in worship and for a variety of ornamental goods. -
Anticancer Activity of Lignan from the Aerial Parts of Saussurea Salicifolia (L.) DC
Vol. 27, 2009, Special Issue Czech J. Food Sci. Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC. G. CHUNSRiiMYATAV1, 2*, I. HOZA1, P. VALÁšEK1, S. SKROVANKOVÁ1, D. BANZRAgcH2 and N. TsEVEgsUREN3 1Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic; 2 Institute of Chemistry and Chemical Technology, Mongolian Academy Sciences, Ulaanbaatar, MON 51 Mongolia; 3Department of Organic Chemistry, Faculty of Chemistry, National University of Mongolia, Ulaanbaatar, Mongolia, *E-mail: [email protected] Abstract: Aerial parts of Saussurea salicifolia (L.) DC were studied for their lignan and flavonoids in solvent chloroform and n-butanol of ethanolic extract. Isolation and identification of phenolic compounds of the chloroform and n-butanol fractions were performed with Dionex HPLC-DAD system with water-methanol gradients in 4 different wave lengths (235 nm, 254 nm, 280 nm and 340 nm), using online UV and LC-MS as described previously. 9-OH-pinoresinol which is a lignan with anticancer activity was dominated in the chloroform fraction, whereas mainly flavonoid glycosides like quercetin-3-O-galactoside, apigenin-7-O-rhamnoside with anti-inflammatory effect were detected in the n-butanol fraction. Additionally, 9-OH-pinoresinol was also found in the n-butanol fraction. Anticancer tests were conducted in leukemia mouse lymphoma cells L5178Y at a concentration of 10 μg/ml of test compound. Crude ethanol extract of S. salicifolia reduced the growth of leukemia mouse lymphoma cells L5178Y to 23.8%. Keywords: flavonoids; Saussurea salicifolia; anticancer activity; Dionex HPLC-DAD system INTRODUCTION several species of Saussurea by other scientists in the world have revealed the presence of interest- Saussurea salicifolia is a medicinal plant belong- ing bioactive compounds like flavonoids (Jiang ing to genus of Saussurea of Asteraceae family. -
A Cytotoxic C-Glycosylated Derivative of Apigenin from the Leaves Of
Revista Brasileira de Farmacognosia 26 (2016) 763–766 ww w.elsevier.com/locate/bjp Short communication A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum a,b,∗ c,d Mohamed I.S. Abdelhady , Amira Abdel Motaal a Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt b Pharmacognosy Department, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia c Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt d Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo, Egypt a b s t r a c t a r t i c l e i n f o Article history: The standardized 80% ethanolic extract of the leaves of Ocimum basilicum var. thyrsiflorum (L.) Benth., Received 12 February 2016 Lamiaceae, growing in KSA, exhibited a significant antioxidant activity compared to the ethyl acetate and Accepted 7 June 2016 butanol extracts, which was correlated to its higher phenolic and flavonoid contents. Chromatographic Available online 20 July 2016 separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3 -O- Keywords: acetylvitexin. Compound 3 -O-acetylvitexin, a C-glycosylated derivative of apigenin, was isolated for the Ocimum basilicum first time from genus Ocimum. The 80% ethanolic extract and 3 -O-acetylvitexin showed significant cyto- HCT116 toxic activities against the HCT human colon cancer cell line [IC values 22.3 ± 1.1 and 16.8 ± 2.0 g/ml Cytotoxic 116 50 Antioxidant (35.4 M), respectively]. -
Characterization of the Inhibition of Genistein
CHARACTERIZATION OF THE INHIBITION OF GENISTEIN GLUCURONIDATION BY BISPHENOL A IN HUMAN AND RAT LIVER MICROSOMES By JANIS LAURA COUGHLIN A thesis submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey and The Graduate School of Biomedical Sciences University of Medicine and Dentistry of New Jersey in partial fulfillment of the requirements for the degree of Master of Science Joint Graduate Program in Toxicology written under the direction of Dr. Brian Buckley and approved by __________________________________ __________________________________ __________________________________ __________________________________ New Brunswick, New Jersey OCTOBER 2011 ABSTRACT OF THE THESIS Characterization of the Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes By JANIS LAURA COUGHLIN Thesis Director: Dr. Brian Buckley Genistein is a natural phytoestrogen that is found abundantly in the soybean. Bisphenol A (BPA) is a synthetic chemical used in the synthesis of polycarbonate plastics and epoxy resins. Endocrine disrupting properties of both genistein and BPA have been well established by various laboratories. Because the adverse biological effects caused by genistein and BPA are similar, and may include common co-exposure scenarios in the general population such as in the consumption of a soy-milk latte from a polycarbonate plastic coffee mug, analysis of the perturbation of the metabolism via glucuronidation of genistein in the presence of BPA has been assessed. Human and rat liver microsomes were exposed to varying doses of genistein (0 to 250 μM) in the absence (0 μM) or presence (25 μM) of BPA. Treatment with 25 μM BPA caused non-competitive inhibition of the glucuronidation of genistein in human liver microsomes with a Ki value of 58.7 μM, represented by a decrease in Vmax from 0.93 ± 0.10 nmol/min/mg in the ii absence of BPA to 0.62 ± 0.05 nmol/min/mg in the presence of BPA, and a negligible change in Km values between treatment groups. -
In Vitro Study of Flavonoids, Fatty Acids, and Steroids on Proliferation of Rat Hepatic Stellate Cells Farid A
In vitro Study of Flavonoids, Fatty Acids, and Steroids on Proliferation of Rat Hepatic Stellate Cells Farid A. Badriaa,*, Abdel-Aziz A. Dawidarb, Wael E. Houssena, and Wayne T. Shierc a Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. E-mail: [email protected] b Chemistry Department, Faculty of Sciences, Mansoura University, Mansoura 35516 Egypt c Medicinal Chemistry Department, College of Pharmacy, University of Minnesota, Minne- apolis MN 55455 USA * Author for correspondence and reprint requests Z. Naturforsch. 60c, 139Ð142 (2005); received November 9/December 8, 2004 There is a wealth of evidence that hepatic stellate cells (HSCs) orchestrate most of the important events in liver fibrogenesis. After liver injury, HSCs become activated to a profi- brogenic myofibroblastic phenotype and can regulate net deposition of collagens and other matrix proteins in the liver. The proliferation of HSCs is mainly stimulated by the platelet- derived growth factor (PDGF). In this study, some compounds from natural resources have been tested for their activity to inhibit PDGF-driven proliferative activity of rat HSCs. Api- genin, quercetin, genistein, daidzin, and biochanin A exhibited > 75% inhibitory activity against HSC-T6. It was found that, γ-linolenic (γ-Ln), eicosapentanoic (EPA) and α- linolenic (α-Ln) acids showed a high inhibitory effect on proliferation of rat HSCs at 50 nmol/l. Cholest-4-ene-3,6-dione and stigmastone-4-en-3,6-dione are the most active steroids with in- hibitory activities > 80% and this is most likely due to the presence of the 4-en-3,6-dione moiety in both compounds. -
Simultaneous Determination of Isoflavones, Saponins And
September 2013 Regular Article Chem. Pharm. Bull. 61(9) 941–951 (2013) 941 Simultaneous Determination of Isoflavones, Saponins and Flavones in Flos Puerariae by Ultra Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry Jing Lu,a Yuanyuan Xie,a Yao Tan, a Jialin Qu,a Hisashi Matsuda,b Masayuki Yoshikawa,b and Dan Yuan*,a a School of Traditional Chinese Medicine, Shenyang Pharmaceutical University; 103 Wenhua Rd., Shenyang 110016, P.R. China: and b Department of Pharmacognosy, Kyoto Pharmaceutical University; Shichono-cho, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. Received April 7, 2013; accepted June 6, 2013; advance publication released online June 12, 2013 An ultra performance liquid chromatography (UPLC) coupled with quadrupole time-of-flight mass spectrometry (QTOF/MS) method is established for the rapid analysis of isoflavones, saponins and flavones in 16 samples originated from the flowers of Pueraria lobata and P. thomsonii. A total of 25 isoflavones, 13 saponins and 3 flavones were identified by co-chromatography of sample extract with authentic standards and comparing the retention time, UV spectra, characteristic molecular ions and fragment ions with those of authentic standards, or tentatively identified by MS/MS determination along with Mass Fragment software. Moreover, the method was validated for the simultaneous quantification of 29 components. The samples from two Pueraria flowers significantly differed in the quality and quantity of isoflavones, saponins and flavones, which allows the possibility of showing their chemical distinctness, and may be useful in their standardiza- tion and quality control. Dataset obtained from UPLC-MS was processed with principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) to holistically compare the dif- ference between both Pueraria flowers. -
Endocrine-Immune-Paracrine Interactions in Prostate Cells As Targeted by Phytomedicines
Published OnlineFirst January 13, 2009; DOI: 10.1158/1940-6207.CAPR-08-0062 Published Online First on January 13, 2009 as 10.1158/1940-6207.CAPR-08-0062 Cancer Prevention Research Endocrine-Immune-Paracrine Interactions in Prostate Cells as Targeted by Phytomedicines Nora E. Gray, Xunxian Liu, Renee Choi, Marc R. Blackman and Julia T. Arnold Abstract Dehydroepiandrosterone (DHEA) is used as a dietary supplement and can be metabolized to androgens and/or estrogens in the prostate. We investigated the hypothesis that DHEA metabolism may be increased in a reactive prostate stroma environment in the presence of proinflammatory cytokinessuchastransforminggrowth factor β1(TGFβ1), and further, whether red clover extract, which contains a variety of compounds including isoflavones, can reverse this effect. LAPC-4 prostate cancer cells were grown in coculture with prostate stromal cells (6S) and treated with DHEA +/− TGFβ1 or interleukin-6. Prostate-specific anti- gen (PSA) expression and testosterone secretion in LAPC-4/6S cocultures were compared with those in monocultured epithelial and stromal cells by real-time PCR and/or ELISA. Combined administration of TGFβ1 + DHEA to cocultures increased PSA protein secretion two to four times, and PSA gene expression up to 50-fold. DHEA + TGFβ1 also increased coculture production of testosterone over DHEA treatment alone. Red clover isoflavone treatment led to a dose-dependent decrease in PSA protein and gene expression and tes- tosterone metabolism induced by TGFβ1 + DHEA in prostate LAPC-4/6S cocultures. In this coculture model of endocrine-immune-paracrine interactionsin the prostate,TGF β1 greatly increased stromal-mediated DHEA effects on testosterone production and epithelial cell PSA production, whereas red clover isoflavones reversed these effects. -
Influence of the Nuclear Hormone Receptor Axis in the Progression and Treatment of Hormone Dependent Cancers
Influence of the nuclear hormone receptor axis in the progression and treatment of hormone dependent cancers A dissertation submitted to the Division of Research and Advanced Studies at the University of Cincinnati in partial fulfillment of the requirements for the degree of Doctorate of Philosophy (Ph.D.) In the Department of Cell and Cancer Biology of the College of Medicine 2007 by Janet K. Hess-Wilson B.A., Wittenberg University, 2000 Committee Chair: Karen E. Knudsen, Ph.D. Abstract Due to its pivotal role in prostatic growth and survival, the androgen receptor (AR) is the primary target of disseminated prostate cancer (CaP), as achieved via androgen deprivation therapy (ADT). Unfortunately, ADT is circumvented by restoration of AR activity, resulting in ADT resistant tumors for which there is no alternate treatment option. Through multiple mechanisms, reactivation of the AR specifically underlies the progression to therapy resistant tumors. The environmentally prevalent endocrine disrupting compound (EDC), bisphenol A (BPA) is able to activate specific somatically mutated ARs commonly found in CaP, resulting in androgen-independent proliferation of CaP cells. To directly assess the effect of BPA on ADT, we used an in vivo xenograft model of CaP that expresses a BPA-sensitive mutant AR, and mimics standard human cytotoxic response to ADT, followed by subsequent tumor re-growth. When tumor- bearing animals were exposed to environmentally relevant levels of BPA during ADT, the tumors failed therapy more rapidly (compared to placebo controls), with AR re- activation and concomitant increased tumor cell proliferation. These data suggest that environmentally relevant exposure to EDCs may reduce the efficacy of mainline ADT for CaP. -
Multi-Discipline Review
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 211801Orig1s000 MULTI-DISCIPLINE REVIEW Summary Review Office Director Cross Discipline Team Leader Review Clinical Review Non-Clinical Review Statistical Review Clinical Pharmacology Review NDA/BLA Multidisciplinary Review and Evaluation NDA 211801 IBSRELA (tenapanor) NDA/BLA Multidisciplinary Review and Evaluation Application Type New Drug Application (NDA) Application Number(s) 211801 (IND #108,732) Priority or Standard Standard Submit Date(s) 09/12/2018 Received Date(s) 09/12/2018 PDUFA Goal Date 09/12/2019 Division/Office Division of Gastroenterology and Inborn Errors Products (DGIEP)/ Office of Drug Evaluation III (ODE III) Review Completion Date 09/10/2019 Established/Proper Name Tenapanor (RDX5791; AZD1722) (Proposed) Trade Name Ibsrela Pharmacologic Class Sodium/hydrogen exchanger 3 (NHE3) inhibitor Code name Applicant Ardelyx, Inc. Dosage form Oral tablets Applicant proposed Dosing 50 mg orally twice daily Regimen Applicant Proposed Treatment of Irritable Bowel Syndrome with Constipation (IBS-C) in Indication(s)/Population(s) Adults Applicant Proposed 440630006 SNOMED CT Indication Disease Term for each Proposed Indication Recommendation on Approval Regulatory Action Recommended Treatment of Irritable Bowel Syndrome with Constipation (IBS-C) in Indication(s)/Population(s) Adults (if applicable) Recommended Dosing 50 mg orally twice daily Regimen i Version date: September 12, 2018 Reference ID: 4490899 NDA/BLA Multidisciplinary Review and Evaluation NDA 211801 IBSRELA