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Innovating Antibodies, Improving Lives

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Innovating Antibodies, Improving Lives Innovating Antibodies, Improving Lives Investor Presentation February 2021 © Genmab For Investor audience only. Not for public information or use. Not for promotional use. Forward looking This presentation contains forward looking outcome of clinical trials, slower than expected statements. The words “believe”, “expect”, rates of patient recruitment, unforeseen safety statement “anticipate”, “intend” and “plan” and similar issues resulting from the administration of our expressions identify forward looking statements. products in patients, uncertainties related to All statements other than statements of historical product manufacturing, the lack of market facts included in this presentation, including, acceptance of our products, our inability to without limitation, those regarding our financial manage growth, the competitive environment in position, business strategy, plans and objectives relation to our business area and markets, our of management for future operations (including inability to attract and retain suitably qualified development plans and objectives relating to our personnel, the unenforceability or lack of products), are forward looking statements. Such protection of our patents and proprietary rights, forward looking statements involve known and our relationships with affiliated entities, changes unknown risks, uncertainties and other factors and developments in technology which may which may cause our actual results, render our products obsolete, and other factors. performance or achievements to be materially Further, certain forward looking statements are different from any future results, performance or based upon assumptions of future events which achievements expressed or implied by such may not prove to be accurate. The forward forward looking statements. Such forward looking statements in this document speak only looking statements are based on numerous as at the date of this presentation. Genmab does assumptions regarding our present and future not undertake any obligation to update or revise business strategies and the environment in forward looking statements in this presentation which we will operate in the future. The nor to confirm such statements to reflect important factors that could cause our actual subsequent events or circumstances after the results, performance or achievements to differ date made or in relation to actual results, unless materially from those in the forward looking required by law. statements include, among others, risks associated with product discovery and development, uncertainties related to the © Genmab 2 For Investor audience only. Not for public information or use. Not for promotional use. Our Core Purpose, Strategy & Vision On the Road to 2025: Guide Our Work Evolving Into a Fully Integrated Biotech Core Purpose To improve the lives of patients by creating & developing innovative antibody products Our Strategy Focus on core competence Turn science into medicine Build a profitable & successful biotech Vision By 2025, our own product has transformed cancer treatment and we have a pipeline of knock-your-socks off antibodies © Genmab 3 For Investor audience only. Not for public information or use. Not for promotional use. Well Positioned for Future Growth Consistent and solid World-class pipeline & Partnerships Strong Financials track record innovation with two with innovators and to invest in growth potential near-term industry leaders opportunities launches © Genmab 4 For Investor audience only. Not for public information or use. Not for promotional use. Consistent, Solid Track Record Fuels Our Growth: Over 20 Years of Achievements 38 Cumulative INDs Multiple Genmab-created Experienced, international since 1999 products approved management team 22 clinical-stage product 8 Years of profitability & Dual-listed in US & DK with candidates based on Genmab’s expanding top line 2019 US IPO innovation Investing in our capabilities First BLA submission © Genmab 5 For Investor audience only. Not for public information or use. Not for promotional use. The Genmab Difference Strong pipeline of 1st-in-class / best-in-class products Deep insight into Proprietary technologies antibody biology allow us to build a & disease targets world-class pipeline Match in-house expertise with strategic partnerships © Genmab 6 For Investor audience only. Not for public information or use. Not for promotional use. Innovative Clinical Pipeline: Genmab Proprietary* and Partnered Products - Most Advanced Development Phase Phase 1 Phase 1/2 Phase 2 Phase 3 Approved‡ 1 2 Genmab DuoBody-CD40x4-1BB1 DuoBody-PD-L1x4-1BB Epcoritamab 9 owned DuoHexaBody-CD372 Tisotumab vedotin products (BLA submitted) 2 ≥50% DuoBody-CD3x5T4 HexaBody-DR5/DR5 3 3 3 JNJ-637091783 Teclistamab Amivantamab Daratumumab (BLA submitted) Talquetamab3 Ofatumumab10 Products JNJ-638980813 6 11 owned by JNJ-675712443 Mim8 Teprotumumab 3rd party 7 JNJ-702189023 Camidanlumab tesirine 8 HuMax-IL84 PRV-015 Lu AF824225 *Products where Genmab has ownership of at least 50% ‡See local prescribing information for full indications / safety information 150:50 partnership with BioNTech 250:50 partnership with AbbVie; 3Development by Janssen Biotech, Inc; 4Development by BMS; 5Development by Lundbeck; 6Development by Novo Nordisk, approved in the US; 7Development by ADC Therapeutics; 8Development by Provention Bio; 950:50 partnership with Seagen; 10Development by Novartis; © Genmab 7 11Development by Horizon Therapeutics, approved in the US For Investor audience only. Not for public information or use. Not for promotional use. Investing in the Breadth & Depth of our Pipeline Expanding & maturing trials for our proprietary* assets R&D Engine: Our Technology Platforms • DuoBody® Clinical Trials Clinical • HexaBody® • DuoHexaBody® • HexElect® 2016 2018 2020 2021e Phase 1/2 Phase 2 Phase 3 © Genmab 8 For Investor audience only. Not for public information or use. Not for promotional use. *Genmab owned ≥50%; number of active clinical trials >20 expected in 2021 In Phase 2 innovaTV 204 study: Tisotumab vedotin Tisotumab Vedotin demonstrated very favorable, durable responses and a manageable safety profile in 2L+ r/m cervical in Collaboration with Seagen cancer patients First-in-class • Antibody–drug conjugate (ADC) directed against Tissue Factor (TF) • Phase 3 study in Recurrent or Metastatic Cervical Cancer (innovaTV 301) recruiting • BLA submitted, recurrent or metastatic cervical cancer Very favorable efficacy with manageable safety profile • Very favorable overall response in Phase 2 innovaTV 204 study vs. prior reported SoC, with manageable safety profile Broad population in innovaTV 204 study • Not restricted to biomarker selection • Pre-treated as per current SoC • Regardless of histology © Genmab 9 For Investor audience only. Not for public information or use. Not for promotional use. Currently investigated in several clinical trials across Epcoritamab B-cell NHL histologies / in various combinations: Phase 3 DLBCL; Phase 2 expansion part ongoing; in Collaboration with AbbVie Phase 1b exploring combinations with multiple SoC treatments Novel MoA • Bispecific T cell engager [DuoBody] Potential best-in-class • Potential for Improved efficacy & safety Subcutaneous administration • Enhanced convenience & ease of administration for HCPs & patients compared to IV infusion Comprehensive development plan • Trials in several B-cell malignancies • Trials across multiple lines of therapy • Exploration as both monotherapy and in combination © Genmab 10 For Investor audience only. Not for public information or use. Not for promotional use. Epcoritamab: Potential Best-in-Class Updated Dose-escalation Data Presented at ASH 2020* Novel, off-the-shelf therapy with Favorable safety profile convenient SubQ administration • Supports potential for • Phase 1/2 study (NCT03625037) in combination therapies / future patients with relapsed, progressive or outpatient administration refractory B-cell lymphoma • CRS events were Grade 1 and 2 • RP2D: 48 mg reached with no DLTs; MTD not reached Demonstrated substantial single-agent activity Binds to distinct epitope in heavily pre-treated patients with B-NHL • Different from that of rituximab and obinutuzumab: • Patients with DLBCL receiving ≥48 mg: • Has potential to be partner of • Responses achieved in 10 of 11 evaluable choice in combinations with SoC patients, including CR in 6 patients therapies containing rituximab • All patients receiving ≥12 mg who achieved CR remain in remission • Patients with FL receiving ≥12 mg: ORR was 80%, with 60% CR • Encouraging responses, including CR, observed in 2 of 4 evaluable patients with MCL 11 *”Subcutaneous Epcoritamab Induces Complete Responses with an Encouraging Safety Profile Across Relapsed/Refractory B-cell © Genmab Non-Hodgkin Lymphoma Subtypes, Including Patients with Prior CAR-T Therapy: Updated Dose-escalation Data” Hutchings, et al. For Investor audience only. Not for public information or use. Not for promotional use. DuoBody-PD-L1x4-1BB (GEN1046) & DuoBody-CD40x4-1BB (GEN1042) in Collaboration with BioNTech GEN1046 GEN1042 • First-in-class bispecific next • First-in-class bispecific generation checkpoint antibody immunotherapy • Designed to conditionally • Designed to enhance T-cell activate both CD40- and NK cell function through expressing antigen- conditional 4-1BB co-stimulation presenting cells (APC) and • Simultaneously blocking the 4-1BB-expressing T cells PD-L1 axis • Conditionally activates T cells • Enhances proliferation and APC in the presence
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