Pharmaceutical Markets in the German Empire

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Pharmaceutical Markets in the German Empire www.ssoar.info Pharmaceutical markets in the German Empire: profits between risk, altruism and regulation Hüntelmann, Axel C. Veröffentlichungsversion / Published Version Zeitschriftenartikel / journal article Zur Verfügung gestellt in Kooperation mit / provided in cooperation with: GESIS - Leibniz-Institut für Sozialwissenschaften Empfohlene Zitierung / Suggested Citation: Hüntelmann, A. C. (2011). Pharmaceutical markets in the German Empire: profits between risk, altruism and regulation. Historical Social Research, 36(3), 182-201. https://doi.org/10.12759/hsr.36.2011.3.182-201 Nutzungsbedingungen: Terms of use: Dieser Text wird unter einer CC BY Lizenz (Namensnennung) zur This document is made available under a CC BY Licence Verfügung gestellt. Nähere Auskünfte zu den CC-Lizenzen finden (Attribution). For more Information see: Sie hier: https://creativecommons.org/licenses/by/4.0 https://creativecommons.org/licenses/by/4.0/deed.de Diese Version ist zitierbar unter / This version is citable under: https://nbn-resolving.org/urn:nbn:de:0168-ssoar-357599 Pharmaceutical Markets in the German Empire. Profits Between Risk, Altruism and Regulation Axel C. Hüntelmann Abstract: »Pharma-Märkte im Deutschen Kaiserreich. Profite zwischen Risi- ko, Altruismus und Regulierung«. For the first time in August 1894, phials of anti-diphtheria serum went on sale in German pharmacies. Anti-diphtheria se- rum was a major therapeutic innovation in the treatment of a terrible infectious disease. The anti-diphtheria serum also signalled the evolution of new regula- tory institutions, as well as new markets in industrially produced pharmaceu- tics. The new serum therapy offered not only a cure for diphtheria and other fatal infectious diseases, but also promised high profits for the manufacturers who could stabilize the production process. It attracted the state’s attention for a number of reasons: the ambiguous legal situation, the production of serum for the free market and the prospect of high profits for the serum industry, and finally the novelty of serum therapy itself and the lack of information about its long-term effects. Drawing on concepts from economic sociology, I will argue that the evolving serum market was formatted by state authorities from the very first moment. This regulation was not imposed by “the state” but negoti- ated among actors like state officials, medical and public health professionals, and serum producers. Keywords: pharmaceutical market, anti-diphtheria serum, public health risk, state regulation of pharmaceuticals. For the first time in August 1894, phials of anti-diphtheria serum produced by the Farbwerke vorm. Meister Lucius & Brüning in the town of Hoechst went on sale in German pharmacies. One month later, at the Eighth International Congress of Hygiene in Budapest, the scientific world was introduced to the new therapy against diphtheria and the serum was greeted as a great break- through in the treatment of a terrible disease.1 The anti-diphtheria serum was a Address all communications to: Axel C. Hüntelmann, Bielefeld Graduate School in History and Sociology, Universitaet Bielefeld, Postfach 10 01 31, 33501 Bielefeld, Germany; e- mail: [email protected]. 1 For example: Émile Roux to Émile Duclaux, Head of the Pasteur Institute, 15.9.1894, Museum of the Pasteur Institute, fol. 11504. A report about the congress in La semaine médicale, 14 (Issue 51, 8.9.1894); Le Bulletin Médical (1894), pp. 827-829, 844-845, the paper of Roux given on the Congress on pp. 1165-1168. For Germany see several articles of German newspapers in the Bundesarchiv Berlin (Federal Archive, henceforth BA Ber- lin), R 86/1182; a report in the Deutsche Medizinische Wochenschrift, 20 (Issue 35-37, 1894), pp. 700-703, 715, 729-731; detailed and with a print of several talks given in Buda- pest in Centralblatt für Bakteriologie und Parasitenkunde, 16 (1894), pp. 737-742, 778-784, Historical Social Research, Vol. 36 — 2011 — No. 3, 182-201 major therapeutic innovation – celebrated as a milestone in bacteriology and a revolution in pharmacology2 – at the end of the 19th century. Representing a new form of therapy, the innovation of anti-diphtheria serum marks the starting point for many other biological therapies. The anti-diphtheria serum also sig- nalled the evolution of new regulatory institutions, as well as new markets in industrially produced pharmaceutics. Antitoxin was the therapeutic agent contained in the anti-diphtheria serum. The new serum therapy offered not only a cure for diphtheria and other fatal infectious diseases, but also promised high profits for the manufacturers who could stabilize the production process and produce the serum in large industrial quantities. Given that there was no patent on the anti-diphtheria serum and that research results were freely available in prominent medical publications, a health professional trained in bacteriology could reconstruct the experiments and produce serum without breaking the law. The new serum therapy attracted the state’s attention for a number of reasons: the ambiguous legal situation, the production of serum for the free market and the prospect of high profits for the serum industry, the experience a few years earlier with tuberculin and the pub- lic health scandal it had triggered, and finally the novelty of serum therapy itself and the lack of information about its long-term effects. Thus, in hopes of minimizing public health risks, the state implemented and institutionalized a strict regime of control. In his book on the Architecture of Markets, Neil Fligstein highlights the im- portance of governments to markets by investigating the sociology of market processes and the socio-political embeddedness of markets.3 Public infrastruc- ture and institutions, social structures and social relations, or the legal system have a major influence on the free market – if they are not the premise for market society – by guaranteeing the functioning of markets. In order to define the “terrain of a sociology of markets”, Fligstein scrutinizes the relation be- tween state and firms in the process of the production of markets and the dy- namics by which markets are created, stabilized and transformed.4 This per- 822-826, 881-896, 908-914, 955-959, 960-965, 1013-1018, 1054-1058; and in the Deutsche Vierteljahrsschrift für öffentliche Gesundheitspflege, 27 (1895), pp. 209-276, 401-464. 2 Cf. Hanspeter Mochmann/Werner Köhler, Meilensteine der Bakteriologie. Von Entdeckun- gen und Entdeckern aus den Gründerjahren der Medizinischen Mikrobiologie, Jena 1984; Heinz Schott (ed.), Meilensteine der Medizin, Dortmund 1996; Wolf-Dieter Müller- Jahncke/Christoph Friedrich/ Ulrich Meyer, Arzneimittelgeschichte, 2. ed., Stuttgart 2005; Ann S. Persson, Smallpox, Syphilis and Salvation. Medical Breakthroughs that changed the World, Wollombi 2009. 3 Cf. Neil Fligstein, The Architecture of Markets. An Economic Sociology of Twentieth- First-Century Capitalist Societies, Princeton 2001. 4 Cf. Ibid., p. 3-23. Fligstein asks first for the social rules that must exist for markets to function, and the social structures that are necessary to produce stable markets (10 f.). Sec- ondly, he investigates the “relation between states and firms in the production of markets” (11-13). Thirdly, he is looking for the social and – in opposition to this – the economic 183 spective is applied and discussed in the following article. With reference to Fligstein, I will argue that the evolving serum market was formatted by the state from the very first moment. Even after the serum market became stabi- lized and the forces of supply and demand seemed to be free from direct inter- vention like in the neo-classical market model, the market remained strictly regulated. This regulation was not imposed by “the state” but negotiated among actors like state officials, medical and public health professionals, and serum producers.5 In this article, I will sketch the framework of pharmaceutical markets in the German Empire, and focus on the evolving market of biologicals around 1900 (1). The years around the fin-de-siècle mark a turning point in the history of pharmaceuticals. After a review of the market organization of remedies up to the 1890s (2), I will examine why there was a need for state regulation (3) and how the process of regulation became stabilized and institutionalized by sum- marizing the further course of events after the anti-diphtheria serum had been introduced to the public in the summer of 1894. Shortly after the launching of anti-diphtheria serum, a state-run institution of serum regulation had been established (4). Thereafter I will frame the market and distinguish the demand side, the supply side, and the price and the product as essential elements of the market (5a-c). Finally, I will look forward to subsequent developments (6) and embed the evolving market for ‘biologicals’ in its historical context (7). 1. Actors of the Drug Market – (what are we talking about) What does a market for drugs mean? And what meanings does the term “drug” include? From the perspective of sick people and suffering patients we are talking about pain-relieving substances or life-saving remedies, from the view- point of the practitioner we are talking about an object that gives him or her the power to cure ill-feeling persons. From the outlook of the practitioner, but also from the perspective of the apothecary and the pharmacologist drugs are scien- tific objects, or objects of knowledge. For practitioners, apothecaries and espe- cially for the chemical industry drugs are also economic commodities that were produced and sold in pharmacies, offering prospective benefits. But drugs are not simple commodities, they are precarious matters, difficult to handle – im- “view of what actors seek to do in markets” (13f.). Forthly, Fligstein takes into view the dynamics “by which the markets are created, attain stability, and are transformed” (14). Fi- nally, he is asking for the “implications of market dynamics for the internal structuring of firms and labor markets” (14 f.). 5 The market is understood here as an arena of social action where coordination problems between the different market actors were levelled out.
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