DMD Fast Forward. Published on November 5, 2020 as DOI: 10.1124/dmd.120.000240 This article has not been copyedited and formatted. The final version may differ from this version. Title page Regulation of intestinal UGT1A1 by the FXR agonist obeticholic acid (OCA) is controlled by CAR through intestinal maturation Downloaded from André A. Weber1, Elvira Mennillo1, Xiaojing Yang1, Lori W.E. van der Schoor2, Johan W. Jonker2, Shujuan Chen1, Robert H. Tukey1,* dmd.aspetjournals.org 1Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. at ASPET Journals on September 25, 2021 2Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands. Address correspondence to: Robert H. Tukey, Department of Pharmacology, University of California, San Diego 92093-0722. E-mail:
[email protected] 1 DMD Fast Forward. Published on November 5, 2020 as DOI: 10.1124/dmd.120.000240 This article has not been copyedited and formatted. The final version may differ from this version. Running title page Running title: CAR activation by OCA induces UGT1A1 and IEC maturation Corresponding author: Robert H. Tukey, Department of Pharmacology, University of California, San Diego 9500 Gilman Drive, La Jolla, California, 92093-0722. E-mail:
[email protected] Text pages: 16 (Abstract – Discussion, not including references and figure legends) Downloaded from Tables: 1 Figures: 7