plants Article The Active Compounds and Therapeutic Mechanisms of Pentaherbs Formula for Oral and Topical Treatment of Atopic Dermatitis Based on Network Pharmacology Man Chu 1, Miranda Sin-Man Tsang 2,3, Ru He 1, Christopher Wai-Kei Lam 4, Zhi Bo Quan 1,* and Chun Kwok Wong 2,3,5,* 1 Faulty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China;
[email protected] (M.C.);
[email protected] (R.H.) 2 Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong 999077, China;
[email protected] 3 State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong 999077, China 4 State Key Laboratory of Quality Research in Chinese Medicines and Faculty of Medicine, Macau University of Science and Technology, Macau 999078, China;
[email protected] 5 Li Dak Sum Yip Yio Chin R & D Centre for Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong 999077, China * Correspondence:
[email protected] (Z.B.Q.);
[email protected] (C.K.W.); Tel.: +86-29-3818-5196 (Z.B.Q.); +852-3505-2964 (C.K.W.); Fax: +86-29-3818-5196 (Z.B.Q.); +852-2636-5090 (C.K.W.) Received: 23 July 2020; Accepted: 7 September 2020; Published: 9 September 2020 Abstract: To examine the molecular targets and therapeutic mechanism of a clinically proven Chinese medicinal pentaherbs formula (PHF) in atopic dermatitis (AD), we analyzed the active compounds and core targets, performed network and molecular docking analysis, and investigated interacting pathways.