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N,N-Dimethylacetamide

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N,N-Dimethylacetamide safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 date of compilation: 2016-06-07 Version: 1.0 en SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier Identification of the substance N,N-Dimethylacetamide Article number 3617 Registration number (REACH) 01-2119459339-27-xxxx Index No 616-011-00-4 EC number 204-826-4 CAS number 127-19-5 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses: laboratory chemical 1.3 Details of the supplier of the safety data sheet Carl Roth GmbH + Co KG Schoemperlenstr. 3-5 D-76185 Karlsruhe Germany Telephone: +49 (0) 721 - 56 06 0 Telefax: +49 (0) 721 - 56 06 149 e-mail: [email protected] Website: www.carlroth.de Competent person responsible for the safety data : Department Health, Safety and Environment sheet e-mail (competent person) : [email protected] 1.4 Emergency telephone number Emergency information service Poison Centre Munich: +49/(0)89 19240 SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 (CLP) Classification acc. to GHS Section Hazard class Hazard class and cat- Hazard egory state- ment 3.1D acute toxicity (dermal) (Acute Tox. 4) H312 3.1I acute toxicity (inhal.) (Acute Tox. 4) H332 3.3 serious eye damage/eye irritation (Eye Irrit. 2) H319 3.7 reproductive toxicity (Repr. 1B) H360D United Kingdom (en) Page 1 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 Remarks For full text of Hazard- and EU Hazard-statements: see SECTION 16. 2.2 Label elements Labelling according to Regulation (EC) No 1272/2008 (CLP) Signal word Danger Pictograms Hazard statements H312+H332 Harmful in contact with skin or if inhaled. H319 Causes serious eye irritation. H360D May damage the unborn child. Precautionary statements Precautionary statements - prevention P280 Wear protective gloves/protective clothing/eye protection/face protection. Precautionary statements - response P302+P352 IF ON SKIN: Wash with plenty of soap and water. P308+P313 IF exposed or concerned: Get medical advice/attention. For professional users only Labelling of packages where the contents do not exceed 125 ml Signal word: Danger Symbol(s) H360D May damage the unborn child. P308+P313 IF exposed or concerned: Get medical advice/attention. 2.3 Other hazards There is no additional information. United Kingdom (en) Page 2 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 SECTION 3: Composition/information on ingredients 3.1 Substances Name of substance N,N-Dimethylacetamide Index No 616-011-00-4 Registration number (REACH) 01-2119459339-27-xxxx EC number 204-826-4 CAS number 127-19-5 Molecular formula C₄H₉NO g Molar mass 87,12 /mol Substance of Very High Concern (SVHC) Name of substance CAS No Wt% Listed in Remarks N,N-dimethylacetamide 127-19-5 100 Candidate list Repr. A57c Legend Candidate list Substances meeting the criteria referred to in Article 57 and for eventual inclusion in Annex XIV Repr. A57c Toxic for reproduction (article 57c) SECTION 4: First aid measures 4.1 Description of first aid measures General notes Take off contaminated clothing. Following inhalation Provide fresh air. If breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. Following skin contact Wash with plenty of soap and water. Frequently or prolonged contact with skin may cause dermal ir- ritation. In case of skin irritation, consult a physician. Following eye contact Irrigate copiously with clean, fresh water for at least 10 minutes, holding the eyelids apart. In case of eye irritation consult an ophthalmologist. Following ingestion Rinse mouth. Do not induce vomiting. In case of accident or unwellness, seek medical advice immedi- ately (show directions for use or safety data sheet if possible). United Kingdom (en) Page 3 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 4.2 Most important symptoms and effects, both acute and delayed Cough, Narcosis, Irritation, Dyspnoea, Inebriation 4.3 Indication of any immediate medical attention and special treatment needed Give sodium sulfate as laxative (1 tablespoon in 1 glass of water). SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Co-ordinate fire-fighting measures to the fire surroundings foam, dry extinguishing powder, carbon dioxide (CO2) Unsuitable extinguishing media water jet 5.2 Special hazards arising from the substance or mixture Combustible. Vapours are heavier than air, spread along floors and form explosive mixtures with air. Hazardous combustion products In case of fire may be liberated: nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2) 5.3 Advice for firefighters Fight fire with normal precautions from a reasonable distance. Wear self-contained breathing appar- atus. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel Wearing of suitable protective equipment (including personal protective equipment referred to under Section 8 of the safety data sheet) to prevent any contamination of skin, eyes and personal clothing. Avoid contact with skin, eyes and clothes. Do not breathe vapour/spray. 6.2 Environmental precautions Keep away from drains, surface and ground water. 6.3 Methods and material for containment and cleaning up Advices on how to contain a spill Covering of drains. Advices on how to clean up a spill Absorb with liquid-binding material (e.g. sand, diatomaceous earth, acid- or universal binding agents). Other information relating to spills and releases Place in appropriate containers for disposal. Ventilate affected area. Reference to other sections Hazardous combustion products: see section 5. Personal protective equipment: see section 8. Incompatible materials: see section 10. Disposal considerations: see section 13. United Kingdom (en) Page 4 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 SECTION 7: Handling and storage 7.1 Precautions for safe handling Provision of sufficient ventilation. • Measures to prevent fire as well as aerosol and dust generation Keep away from sources of ignition - No smoking. Advice on general occupational hygiene Wash hands before breaks and after work. Keep away from food, drink and animal feedingstuffs. 7.2 Conditions for safe storage, including any incompatibilities Store in a well-ventilated place. Keep container tightly closed. Incompatible substances or mixtures Observe hints for combined storage. Consideration of other advice • Ventilation requirements Use local and general ventilation. • Specific designs for storage rooms or vessels Recommended storage temperature: 15 - 25 °C. 7.3 Specific end use(s) No information available. SECTION 8: Exposure controls/personal protection 8.1 Control parameters National limit values Occupational exposure limit values (Workplace Exposure Limits) Cou Name of agent CAS No Nota- Identifi- TWA TWA STEL STEL Source ntry tion er [pp [mg/m [pp [mg/m m] ³] m] ³] EU N,N-dimethylacetamide 127-19-5 IOELV 10 36 20 72 2000/39/EC GB N,N-dimethylacetamide 127-19-5 WEL 10 36 20 72 EH40/2005 Notation STEL Short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15- minute period unless otherwise specified TWA Time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours time-weighted average Biological limit values Coun- Name of agent Parameter Nota- Identifi- Value Material Source try tion er GB N,N-dimethylacetam- N-methylacetamide crea BMGV 100 urine EH40/200 ide mmol/mol 5 Notation crea Creatinine United Kingdom (en) Page 5 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 Relevant DNELs/DMELs/PNECs and other threshold levels • human health values Endpoint Threshold Protection goal, Used in Exposure time level route of exposure DNEL 23 mg/m³ human, inhalatory worker (industry) chronic - systemic effects DNEL 120 mg/m³ human, inhalatory worker (industry) acute - systemic effects DNEL 11 mg/kg human, dermal worker (industry) chronic - systemic effects bw/day DNEL 42 mg/kg human, dermal worker (industry) acute - systemic effects bw/day • environmental values Endpoint Threshold level Environmental compartment Exposure time PNEC 0,5 mg/l freshwater short-term (single instance) PNEC 0,097 mg/l marine water short-term (single instance) PNEC 5 mg/l water continuous PNEC 485 mg/l sewage treatment plant (STP) short-term (single instance) PNEC 2,27 mg/kg freshwater sediment short-term (single instance) PNEC 0,438 mg/kg marine sediment short-term (single instance) PNEC 0,15 mg/kg soil short-term (single instance) 8.2 Exposure controls Individual protection measures (personal protective equipment) Eye/face protection Use safety goggle with side protection. Skin protection • hand protection Wear suitable gloves. Chemical protection gloves are suitable, which are tested according to EN 374. For special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves. • type of material Butyl caoutchouc (butyl rubber) • material thickness 0,7mm. United Kingdom (en) Page 6 / 14 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU N,N-Dimethylacetamide ≥99 %, for synthesis article number: 3617 • breakthrough times of the glove material >480 minutes (permeation: level 6) • other protection measures Take recovery periods for skin regeneration.
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