Statistical Theory and Methodology for the Analysis of Microbial Compositions, with Applications
Statistical Theory and Methodology for the Analysis of Microbial Compositions, with Applications by Huang Lin BS, Xiamen University, China, 2015 Submitted to the Graduate Faculty of the Graduate School of Public Health in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2020 UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH This dissertation was presented by Huang Lin It was defended on April 2nd 2020 and approved by Shyamal Das Peddada, PhD, Professor and Chair, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh Jeanine Buchanich, PhD, Research Associate Professor, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh Ying Ding, PhD, Associate Professor, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh Matthew Rogers, PhD, Research Assistant Professor, Department of Surgery, UPMC Children's Hospital of Pittsburgh Hong Wang, PhD, Research Assistant Professor, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh Dissertation Director: Shyamal Das Peddada, PhD, Professor and Chair, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh ii Copyright c by Huang Lin 2020 iii Statistical Theory and Methodology for the Analysis of Microbial Compositions, with Applications Huang Lin, PhD University of Pittsburgh, 2020 Abstract Increasingly researchers are finding associations between the microbiome and human diseases such as obesity, inflammatory bowel diseases, HIV, and so on. Determining what microbes are significantly different between conditions, known as differential abundance (DA) analysis, and depicting the dependence structure among them, are two of the most challeng- ing and critical problems that have received considerable interest.
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