Pupillary Unrest Correlates with Arousal Symptoms and Motor Signs
BRIEF REPORTS Decades of Delayed Diagnosis We report 4 patients with young-onset parkinson- ism, each of whom was misdiagnosed with a motor in 4 Levodopa-Responsive conversion disorder for at least a decade after their Young-Onset Monogenetic first specialist referral. Parkinsonism Patients Case reports Patient 1 Helen Ling, BScMed, BMBS, MSc,1,2 Mark Braschinsky, A British woman developed gait freezing at age 31 3 3 3 MD, PhD, Pille Taba, MD, Siiri-Merike Lu¨ u¨ s, MD, Karen during her first pregnancy. She then became unsteady Doherty, MB, BCh, BAO, MRCP,1,2 Anna Hotter, MD,4 4 1,2 and clumsy and complained of jerky tremulous hands Werner Poewe, MD, and Andrew J. Lees, MD FRCP * and curling of the toes. She also complained of pro- found fatigue and slowness of thinking. At age 37, she 1Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom; started to have urinary urgency and to fall over. Over 2Queen Square Brain Bank for Neurological Disorders and Institute 14 years, she was seen by 6 neurologists and had of Neurology, University College London, London, United Kingdom; received diagnoses of motor conversion disorder 3Department of Neurology, University of Tartu, Tartu, Estonia; (MCD), chronic fatigue syndrome (CFS), and depres- 4 Department of Neurology, University Hospital of Innsbruck, Austria sion. Her movements were described as distractible, variable, and deliberately slow. Her spontaneous move- ments were considered as strikingly normal in contrast with those found on formal neurological examination. At age 45, she was reviewed at the National Hospital for Neurology and Neurosurgery in Queen Square, ABSTRACT London, where Parkinson’s disease was suspected.
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