The Safe Spinal Anaesthetic Spinal Anaesthesia Is Not Without Its Complications and Should Only Be Performed for the Correct Indications

Total Page:16

File Type:pdf, Size:1020Kb

The Safe Spinal Anaesthetic Spinal Anaesthesia Is Not Without Its Complications and Should Only Be Performed for the Correct Indications The safe spinal anaesthetic Spinal anaesthesia is not without its complications and should only be performed for the correct indications. Mariane Gertruida Senekal, BMedSc, MB ChB, DA, MMed (Anaesthesiology) Principal Specialist, Department of Anaesthesiology, 3 Military Hospital, and Senior Lecturer, Department of Anaesthesiology, University of the Free State, Bloemfontein Mariane Senekal did her undergraduate training at Stellenbosch University and her postgraduate anaesthesia training at the University of the Free State where she obtained the MMed (Anaesthesiology) in 2005. She has an interest in obstetric anaesthesia, orthopaedic anaesthesia, anaesthesia-related physiology and teaching and training of anaesthesia. Correspondence to: M Senekal ([email protected]) Spinal anaesthesia is relatively easy to must be titrated with care. During the avoided. Indications and contra-indications perform and can potentially be excellent postoperative period the patient should are listed in Table 1. for below the umbilicus. However, it be admitted to the recovery room and can also give rise to serious side-effects monitored. Physiology and complications. To perform a safe Local anaesthetic solution injected into the procedure, the anaesthetist must have A spinal anaesthetic subarachnoid space blocks conduction of adequate knowledge of the indications should only be impulses along all nerves with which it comes and contra-indications, and of the relevant in contact. It acts mainly at spinal nerve roots, anatomy, physiology and pharmacology performed for the although some effect is possible at the cord of spinal anaesthesia. The patient must correct indications. itself. Smaller autonomic and sensory fibres be assessed before administration of the are blocked more easily than motor fibres. spinal anaesthetic and the theatre must be Indications and contra- Consequently, it produces a rapid sympathetic correctly prepared. The anaesthetist must indications block, which causes peripheral vasodilatation be familiar with the correct technique. A spinal anaesthetic should only be and hypotension, and the patient may be After administration of the anaesthetic, administered for the correct indications. If aware of pressure or movement but feel no the patient must be monitored so that side- relative contra-indications exist, extreme pain when surgery starts. effects and complications are recognised caution should be taken, and if there are immediately and treated early. Sedatives absolute contra-indications, it should be Table 1. Indications and contra-indications for spinal anaesthesia Indications Surgical procedures to the lower body below the umbilicus Caesarean section Respiratory disease (avoid high blocks) Pain relief Relative contra-indications Aortic stenosis/mitral stenosis (fixed cardiac output states) Systemic sepsis Neurological disease (medicolegal implications) Anatomical deformities of the patient’s back Difficult airway Long operating time Children Absolute contra-indications Inadequate drugs and equipment Clotting disorders/anticoagulation Refusal Severe hypovolaemia or shock Localised sepsis Increased intracranial pressure 16786 ECOTRIN isl-MOD MED.indd 1 3/28/12 1:42:07 PM 207 CME June 2012 Vol.30 No.6 Spinal anaesthesia Preoperative assessment and Table 2. Factors affecting the spread of the local anaesthetic solution premedication Factor Mechanism The preoperative assessment of the patient should be done as for a general anaesthetic. Baricity of the local anaesthetic solution Blocks can be better controlled with hyper- baric solutions It is important to explain the procedure, side-effects and possible complications to Position of the patient Level of the block may change if the patient’s the patient and to obtain informed consent. position is altered It should be explained that although a spinal Concentration of and volume injected A higher concentration produces a denser anaesthetic eliminates pain, the patient may block; a larger volume produces a block over a larger area be aware of some sensation in the relevant area and that the patient’s legs may become Speed of injection Rapid injection produces eddy currents within the CSF and a less predictable spread weak. Patients should be reassured that if they feel pain they will be given a general Increased abdominal pressure Leads to engorgement of the epidural veins and reduction in CSF volume anaesthetic. The usual ‘nil by mouth’ rule (i.e. no solids for 6 hours and no clear fluids up to 2 hours before anaesthesia) must be Intravenous access and it is recommended that spinals should not be observed unless the operation is urgent. preloading inserted above L3/4. Several cases of trauma Premedication is often unnecessary, but if Obtain IV access before starting the block. to the conus are documented in the literature,4 a patient is apprehensive, hydroxyzine may A large bore is recommended, preferably an mostly involving spinal insertion believed be given orally 2 hours before the operation. 18G IV catheter. It seems that no amount of to be above L3/4. Evidence suggests that fluid preloading can prevent hypotension in injection of fluid into the cord may not always Preparation of theatre, all cases, but 500 - 1 000 ml is advantageous. be involved, and that simple needle trauma instruments and drugs Crystalloids are more effective than no is sufficient to produce a syrinx resulting in Facilities for resuscitation and progression to fluids and colloids are more effective than foot drop, numbness and sometimes urinary general anaesthesia must be available. Make crystalloids in preventing hypotension.1 No problems. It is recommended not to inject sure that a reliable anaesthesia machine is differences were detected for different doses, once pain is experienced, but the damage may available, as well as suction and intubation rates or methods of administering colloids already have been done. equipment, and standard anaesthetic and or crystalloids.1 resuscitation drugs. A number of factors affecting the spread The preoperative of the injected local anaesthetic solution within the CSF and the ultimate extent of assessment of the the block are given in Table 2. patient should be done as for a general Local anaesthetics Any anaesthetic technique must produce anaesthetic. adequate surgical anaesthesia of sufficient duration and with minimal side-effects. Positioning the patient, The main side-effect of spinal anaesthesia anatomy, and factors affecting is a reduction in blood pressure. Reducing spread of local anaesthetic the dose of intrathecal local anaesthetic will Patients should be sitting or lying on their improve cardiovascular stability but may side. Back flexion opens the intervertebral not provide adequate surgical anaesthesia. spaces. The spinal cord terminates at L1/2 The anaesthetist needs to decide which local and the subarachnoid space at S2 in adults. It anaesthetic to use and the dose. is advisable to enter the lumbar subarachnoid space below the termination of the cord, Some preparations of local anaesthetics usually between vertebrae L4 and L5. The line contain additives such as preservatives joining the iliac crests is at L3/4 and is called and are not suitable for intrathecal Tuffier’s line. Aim to identify the L3/4, L4/5 or administration. Bupivacaine has a faster L5/S1 interspace. Considering the inaccuracy onset and longer duration (2 - 3 hours) of clinical means of identifying lumbar of analgesia and motor block than both interspaces, the tendency of anaesthetists to ropivacaine and levobupivacaine. The err upwards,2 and the uncertainty of the length duration of action of lignocaine may be too 16786 ECOTRIN isl-MOD MED.indd 1 3/28/12 1:42:07 PM of the spinal cord, even in normal individuals,3 short to guarantee adequate surgical time 208 CME June 2012 Vol.30 No.6 Spinal anaesthesia Table 3. Guideline for local anaesthetic volume (not applicable to pregnant patient head-up. See treatment of a high patients) or total spinal anaesthetic below. Type of block 0.5% hyperbaric bupivacaine Monitoring Saddle block 1 ml Establish full monitoring before Lumbar block 2 - 3 ml administering a spinal anaesthetic, including blood pressure monitoring (preferably with Mid-thoracic block 2 - 4 ml an automatic oscillometric monitor), an electrocardiogram and pulse oximetry. and it has a higher incidence of transient than 60 minutes to fix finally.6 If the patient Confirm the alarm levels for every patient radicular irritation.5 A guideline for the is unable to lift his/her legs from the bed, before starting the anaesthetic. volume of local anaesthetic to be used is the block is at least up to the mid-lumbar given in Table 3. The lower volumes should region. Test for a loss of temperature Side-effects and complications generally be given to small individuals. sensation. The side-effects and complications of spinal anaesthesia are shown in Table 4. Facilities for Problems with the block • No block. If after 10 minutes the patient Treatment of hypotension resuscitation and still has full power in the legs and normal Hypotension is due to vasodilatation progression to general sensation, then the block has failed, and a functional decrease in the effective anaesthesia must be probably because the injection was not circulating volume. This should be treated intrathecal. by reversing the vasodilatation with available. • The block is one-sided. Position the vasoconstrictor drugs and increasing the patient on the side that is inadequately circulating volume by giving IV fluids.
Recommended publications
  • Chapter 17 Spinal, Epidural, and Caudal Anesthesia
    Chapter SPINAL, EPIDURAL, AND 17 CAUDAL ANESTHESIA Alan J.R. Macfarlane, Richard Brull, and Vincent W.S. Chan PRINCIPLES COMBINED SPINAL-EPIDURAL ANESTHESIA PRACTICE Technique ANATOMY CAUDAL ANESTHESIA Spinal Nerves Pharmacology Blood Supply Technique Anatomic Variations COMPLICATIONS MECHANISM OF ACTION Neurologic Drug Uptake and Distribution Cardiovascular Drug Elimination Respiratory PHYSIOLOGIC EFFECTS Infection Cardiovascular Backache Central Nervous System Nausea and Vomiting Respiratory Urinary Retention Gastrointestinal Pruritus Renal Shivering Complications Unique to Epidural Anesthesia INDICATIONS Neuraxial Anesthesia RECENT ADVANCES IN ULTRASONOGRAPHY Neuraxial Analgesia QUESTIONS OF THE DAY CONTRAINDICATIONS Absolute Relative PRINCIPLES SPINAL ANESTHESIA Factors Affecting Block Height Spinal, epidural, and caudal blocks are collectively referred Duration of the Block to as central neuraxial blocks. Significant technical, physi- Pharmacology ologic, and pharmacologic differences exist between the Technique techniques, although all result in one or a combination of Monitoring of the Block sympathetic, sensory, and motor blockade. Spinal anes- EPIDURAL ANESTHESIA thesia requires a small amount of drug to produce rapid, Factors Affecting Epidural Block Height profound, reproducible, but finite sensory analgesia. In Pharmacology contrast, epidural anesthesia progresses more slowly, is Technique commonly prolonged using a catheter, and requires a large amount of local anesthetic, which may be associated with The editors and publisher would like to thank Drs. Kenneth Dras- ner and Merlin D. Larson for contributing to this chapter in the previous edition of this work. It has served as the foundation for the current chapter. 273 Downloaded for Wendy Nguyen ([email protected]) at University Of Minnesota - Twin Cities Campus from ClinicalKey.com by Elsevier on March 26, 2018. For personal use only.
    [Show full text]
  • Spinal Anaesthesia for Laparoscopic Cholecystectomy
    Rev. Col. Anest. Mayo-Julio 2009. Vol. 37- No. 2: 111-118 Spinal anaesthesia for laparoscopic cholecystectomy PatIents and MethOds • Patients aged less than 18 and older than 75; -2 • Patients having greater than 30 Kg/m body A descriptive pros­pective study was carried out mass index (BMI); between June and September 2008 in the Caribe teaching hospital in the city of Cartagena in Co- • Sick patients having contraindication for lapa- lombia, South America. Once the Caribe teaching roscopic surgery; hospital’s medical ethics’ committee’s approval had • Patients having contraindication for spinal been sought and given, patients were included in anaesthesia; the study who had biliary lithiasis accompanied by a clinical picture of chronic cholecystitis as well as • Patients who preferred general anaesthesia; those having a clinical picture of subacute cholecys- and titis diagnosed during preoperative exam. • An inability for carrying out posto­perative follow- Patients who had been previously diagnosed as up. having complicated biliary lithiasis (acute chole- Inclusion criteria consisted of ASA I – II patients cystitis, choledocoli­thiasis, acute cholangitis, acute aged 18 to 75. All the patients complied with a biliary pancreatitis, etc.) were excluded. Other ex- minimum 8 hours fast; antibiotic prophylaxis was clusion criteria were as follows: 115 Anestesia espinal para colecistectomia laparoscópica - Jiménez J.C., Chica J., Vargas D. Rev. Col. Anest. Mayo-Julio 2009. Vol. 37- No. 2: 111-118 administered 15 minutes before the procedure (1 g tolerance to oral route had been produced and the intravenous cephazoline) anaesthesiologist had verified the absence of any type of complication. All patients were prescribed ANAESTHETIC TECHNIQUE ibuprofen as analgesia to be taken at home (400 mgr each 8 hours for 3 days).
    [Show full text]
  • Sedative Effect of Propofol and Midazolam in Surgery Under Spinal Anaesthesia: a Comparative Study
    Indian Journal of Clinical Anaesthesia 2020;7(1):187–191 Content available at: iponlinejournal.com Indian Journal of Clinical Anaesthesia Journal homepage: www.innovativepublication.com Original Research Article Sedative effect of propofol and midazolam in surgery under spinal anaesthesia: A comparative study Jalpen N Patel1, Jyotsna F Maliwad2,*, Purvi J Mehta1, Raman D Damor3, Kalpita S Shringarpure3 1Dept. of Anesthesiology, Shri M P Shah Medical College, Jamnagar, Gujarat, India 2Dept. of Anasthesiology, Medical College, Baroda, Gujarat, India 3Dept. of Community Medicine, Medical College, Baroda, Gujarat, India ARTICLEINFO ABSTRACT Article history: Introduction: Intravenous medications are invariably required to allay anxiety related to surgical Received 27-11-2019 procedures, in patients undergoing surgery under regional anesthesia. A thorough pre anaesthetic check Accepted 30-11-2019 up and details of the surgical procedure planned are necessary before administration of sedative agents to Available online 28-02-2020 attain desirable levels of sedation and avoid unwanted adverse events. Objective: To observe, record and analyse sedative effect of intravenous Propofol and Midazolam in lower extremities and lower abdominal surgery scheduled under regional anesthesia techniques. Keywords: Materials and Methods: A single blinded comparative study conducted in tertiary care hospital of Gujarat. Sedative effect Sixty patients with no organic pathology & a moderate but definite systemic disturbance categorized into Subarachnoid block two groups labeled as propofol group (n=30) and Midazolam group (n=30) of either gender and shortlisted Anxiety for surgery using subarachnoid block. Observer’s Assessment of Alertness/Sedation Scale (OAA/S Scale) and Ramsay sedation scale was used to assess effective sedation. Results: Basic patients characteristics, Mean age (SD) was 31.57 + 10.57 years in category I (P group) and 35.33 + 9.98 years in category II (M group) was comparable between the groups.
    [Show full text]
  • EPIDURAL ANAESTHESIA Dr Leon Visser, Dept
    Update in Anaesthesia 39 EPIDURAL ANAESTHESIA Dr Leon Visser, Dept. of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA INTRODUCTION l Vascular reconstruction of the lower limbs. Epidural anaesthesia is a central neuraxial block Epidural anaesthesia improves distal blood flow in technique with many applications. The epidural space patients undergoing arterial reconstruction surgery. was first described by Corning in 1901, and Fidel l Amputation. Patients given epidural anaesthesia Pages first used epidural anaesthesia in humans in 48-72 hours prior to lower limb amputation may have 1921. In 1945 Tuohy introduced the needle which is a lower incidence of phantom limb pain following still most commonly used for epidural anaesthesia. surgery, although this has not been substantiated. Improvements in equipment, drugs and technique l Obstetrics. Epidural analgesia is indicated in have made it a popular and versatile anaesthetic obstetric patients in difficult or high-risk labour, e.g. technique, with applications in surgery, obstetrics breech, twin pregnancy, pre-eclampsia and prolonged and pain control. Both single injection and catheter labour. Furthermore, Caesarean section performed techniques can be used. Its versatility means it can under central neuraxial block is associated with a lower be used as an anaesthetic, as an analgesic adjuvant to maternal mortality owing to anaesthetic factors than general anaesthesia, and for postoperative analgesia under general anaesthetic. in procedures involving the lower limbs, perineum, pelvis, abdomen and thorax. l Low concentration local anaesthetics, opioids, or combinations of both are effective in the control of INDICATIONS postoperative pain in patients undergoing abdominal General and thoracic procedures. Epidural analgesia has Epidural anaesthesia can be used as sole anaesthetic for been shown to minimise the effects of surgery on procedures involving the lower limbs, pelvis, perineum cardiopulmonary reserve, i.e.
    [Show full text]
  • Your Spinal Anaesthetic This Leaflet Explains What to Expect When You Have an Operation with a Spinal Anaesthetic
    Your spinal anaesthetic This leaflet explains what to expect when you have an operation with a spinal anaesthetic. It has been written by anaesthetists, patients and patient representatives, working together. Introduction This leaflet explains: ■ what a spinal anaesthetic is ■ how it works ■ why you could benefit from having one for your operation. What is a ‘spinal’? For many operations it is usual for patients to have a general anaesthetic. However, for operations in the lower part of the body, sometimes it is often possible for you to have a spinal anaesthetic instead. This is when an anaesthetic is injected into your lower back (between the bones of your spine). This makes the lower part of the body numb so you do not feel the pain of the operation and can stay awake. Typically, a spinal lasts one to two hours. Other drugs may be injected at the same time to help with pain relief for many hours after the anaesthetic has worn off. During your spinal anaesthetic you may be: ■ fully awake ■ sedated – with drugs that make you relaxed, but not unconscious. For some operations a spinal anaesthetic can also be given before a general anaesthetic to give additional pain relief afterwards. Your anaesthetist can help you decide which of these would be best for you. rcoa.ac.uk/patientinfo | 1 Your spinal anaesthetic Many operations in the lower part of the body are suitable for a spinal anaesthetic with or without a general anaesthetic. Depending on your personal health, there may be benefits to you from having a spinal anaesthetic.
    [Show full text]
  • Long QT Syndrome
    orphananesthesia Anaesthesia recommendations for patients suffering from Long QT syndrome Disease name: Long QT syndrome ICD 10: I45.8 Synonyms: LQTS Related syndromes: Romano-Ward S., Jervell and Lange-Nielsen S., Timothy S. Long QT syndrome (LQTS) is a cardiac disorder resulting from malfunction of cardiac ion channels. It can be divided in congenital (c-LQTS) and acquired (a-LQTS) forms. Typical is a prolongation of the QT interval on ECG and a propensity to ventricular tachyarrhythmias which can lead to a characteristic polymorphic ventricular tachycardia known as “torsades de pointes”. There is a risk of syncope, cardiac arrest or sudden death. The diagnosis is based on ECG findings, clinical and family history. The Schwartz score defines the probability of LQTS according to three categories: 1 point, low probability of LQTS; (2) 2 or 3 points, intermediate probability of LQTS; and (3) ≥3.5 points, high probability of LQTS. THE TABLE OF THE SCHWARTZ SCORE should be added here: Table 2 of the paper Schwartz PJ and Crotti L. QTc behavior during exercise and genetic testing for the Long-QT Syndrome: Circulation 2011;124:2181-2184. Medicine in progress Perhaps new knowledge Every patient is unique Perhaps the diagnostic is wrong Find more information on the disease, its centres of reference and patient organisations on Orphanet: www.orpha.net 1 Typical surgery The typical surgery for LQTS is left cardiac sympathetic denervation, which is recommended in patients symptomatic for cardiac events despite beta-blocker (BB) therapy or in patients in whom BBs are contraindicated or not tolerated. For therapeutic reasons the implantation of a cardioverter defibrillator (ICD) is recommended in patients with a previous cardiac arrest or in patients with recurrent syncopal events despite antiadrenergic interventions.
    [Show full text]
  • Safety and Efficacy of Spinal Vs General Anaesthesia in Bone Marrow Harvesting
    Bone Marrow Transplantation, (1998) 21, 1145–1148 1998 Stockton Press All rights reserved 0268–3369/98 $12.00 http://www.stockton-press.co.uk/bmt Safety and efficacy of spinal vs general anaesthesia in bone marrow harvesting ¨ M-A Burmeister1, T Standl1, P Brauer1, K Ramsperger1, N Kroger2, A Zander2 and J Schulte am Esch1 1Department of Anaesthesiology, Bone Marrow Transplantation Unit, and 2Department of Oncology and Haematology, University Hospital Hamburg, Germany Summary: gesia requirement have been demonstrated with RA.4 SPA may also be of interest for economical reasons. Bone marrow harvesting (BMH) can be performed with Nevertheless, SPA with the patient in the prone position either general (GA) or spinal anaesthesia (SPA). Whether is still controversial. One of the main arguments against SPA is advantageous in BMH and if this technique is safe SPA in the prone position is the difficulty in adequately for procedures performed in the prone position is still con- ventilating the patient in the event of respiratory insuf- troversial. To evaluate the safety and efficacy of both ficiency. Several reports have presented cases with cardio- anaesthetic techniques in BMH, 37 allogeneic donors (nine pulmonary arrest and resuscitation during SPA.5–7 female, 28 male; 34.3 ؎ 9 years; ASA class 1–2) received The present prospective study was designed to evaluate either spinal (group 1, n = 20) or general anaesthesia the safety and efficacy of the two different anaesthetic tech- (group 2, n = 17) according to their personal wishes. niques in healthy allogeneic donors undergoing BMH. Under standardised harvesting conditions, haematology parameters, cell counts (MNC, CD34+), haemodynamic parameters, adverse reactions and patient satisfaction Patients and methods were registered.
    [Show full text]
  • Unilateral Fascia Iliaca Block (FIB) for Postoperative Analgesia in Fracture
    ORIGINAL ARTICLE Unilateral Fascia Iliaca Block (FIB) for Post-operative Analgesia in Fracture Neck of Femur Surgery; Comparison with Standard Post-operative Analgesia RIAZ HUSSAIN, TAHIR NAZEER, ASLAM ASIM ABSTRACT Aim: To compare the comfort and post-operative pain in patients undergoing fascia iliaca block with standard post-operative analgesia in fracture neck of femur surgery. Method: 100 patients with ASA class P1, P2 and P3 undergoing surgery were included in this study. Fascia iliaca block (FIB) was applied at the end of surgery. All surgeries were performed under spinal anaesthesia. In group A 50 patients received FIB along with standard postoperative analgesia and in group B, 50 patients received only standard post-operative analgesia with injection diclofenac sodium 75mg IM, 8 hourly and rescue analgesia with 2mg injection nalbuphine according to patient complaint of pain. Results: The degree of pain was significantly lower in patients receiving FIB and they were more comfortable after surgery and quantity of injection nalbuphine rescue analgesia was significantly reduced, compared with patients receiving standard post-operative analgesia only. Conclusion: FIB provides effective post operative analgesia and is associated with markedly reduced analgesia consumption and patient remains more comfortable and satisfied after surgery. Keywords: Nerve blocks, postoperative analgesia, fascia iliaca block, spinal anaesthesia. INTRODUCTION 10 control for at least 24 hours with single short . Post-operative surgical pain is a nightmare
    [Show full text]
  • Spinal Anaesthesia;
    SPINAL ANAESTHESIA The Professional Medical Journal www.theprofesional.com ORIGINAL PROF-2764 SPINAL ANAESTHESIA; COMPARISON BETWEEN PROPHYLACTIC LOW DOSE KETAMINE AND ONDANSETRON FOR PREVENTION OF SHIVERING DURING SPINAL ANAESTHESIA IN PATIENTS UNDERGOING LOWER ABDOMINAL SURGERIES Dr. Muhammad Yousuf1, Dr. Syed Aftab Haider2, Dr. M. Mudassir Aziz3, Dr. Salman Waris4 1. Associate Professor ABSTRACT… Perioperative shivering is a common problem during spinal anaesthesia. It Nishtar Medical College & Hospital, causes tremendous deleterious effects on metabolism of body. Despite of re-warming and Multan 2. Assistant Professor raising the ambient temperature, several drugs are under research to evaluate their preventive Nishtar Medical College & Hospital, role in shivering during anaesthesia like tramadol, butorphanol, midazolam, ketamine and Multan ondansetron. The present study was conducted to evaluate the effect of prophylactic low dose 3. Medical Officer, Nishtar Medical College & Hospital, ketamine and ondansetron for prevention of shivering during spinal anaesthesia. Objective: Multan To compare prophylactic low dose ketamine with ondansetron for prevention of shivering 4. Professor during spinal anaesthesia in patients undergoing lower abdominal surgeries. Study Design: Nishtar Medical College & Hospital, Randomized controlled trial. Setting: Department of Anaesthesia, Nishtar Hospital Multan. Multan Period: November 2012 to May 2013. Material and methods: A total of 256 patients were Correspondence Address: included in the study divided
    [Show full text]
  • The Effect of Anaesthesia and Adrenergic Therapy on the Distribution and Elimination of a Crystalloid Solution Studied by Volume Kinetic Analysis
    The Department of Anaesthesia and Intensive Care Södersjukhuset KAROLINSKA INSTITUTET STOCKHOLM, SWEDEN The Effect of Anaesthesia and Adrenergic Therapy on the Distribution and Elimination of a Crystalloid Solution Studied by Volume Kinetic Analysis Carl-Arne Ewaldsson Stockholm 2006 Previously published papers were reproduced with the permission of the publisher. Published and printed by Karolinska University Press Box 200, SE-171 77 Stockholm, Sweden © Carl-Arne Ewaldsson, 2006 ISBN 91-7140-914-9 2 1 ABSTRACT Intravenous fluid therapy is a mandatory measure during anaesthesia and surgery. It is sometimes combined with adrenergic therapy to maintain haemodynamic stability. It is of great importance to know how the body handles the distribution of fluid in these circumstances in order to minimize the risk of fluid overload. The objective of this thesis was to examine intravenous fluid handling by studying changes in cardiovascular parameters and by using a volume kinetic method to analyze fluid volumes in the body. Methods: In Paper I we studied whether anaesthesia and surgery affect the sensitivity of the β-2 adrenergic receptor in vivo. 10 patients and 10 volunteers were given an intravenous infusion of epinephrine (50 ng/kg/min). Both cardiovascular and biochemical changes were measured for which the ratios of the areas under the curve were calculated. In Paper II an animal model was used to evaluate how different adrenergic stimuli affect the distribution and elimination of crystalloid fluid bolus. The impact of three different drugs (dopamine 50 µg/kg/min, isoprenaline 0.1 µg/kg/min and phenylephrine 3 µg/kg/min) on the relationship between plasma dilution and haemodynamics was evaluated.
    [Show full text]
  • Comparison of Outcomes of Using Spinal Versus General Anesthesia in Total Hip Arthroplasty He Role of Spirin
    An Original Study Comparison of Outcomes of Using The Role of Spinal Versus General Anesthesia in Aspirin Total Hip Arthroplasty Keith R Stephen G. Maurer, MD, Andrew L. Chen, MD, Rudi Hiebert, MSc, Gavin C. Pereira, FRCS, and Paul E. Di Cesare, MD Studies comparing epidural regional versus GA in Abstract patients undergoing THA have reported a correlation Blood loss, operative time, and rate of complications were compared in 606 patients undergoing primary unilateral total between regional anesthesia and shorter operative time, hip arthroplasty with either spinal anesthesia (SA) or general decreased intraoperative and postoperative blood loss, anesthesia (GA). Patients were followed for 2 years after reduced blood replacement, and fewer thromboembolic surgery. Compared with GA, SA resulted in mean reductions complications.6-15 A search of the literature revealed no of 12% in operative time, 25% in estimated intraoperative reports of clinical outcomes in unilateral THA related to blood loss, 38% in rate of operative blood loss, and 50% use of SA. Differences in type, dosage, and placement of in intraoperative transfusion requirements. Compared with anesthesia and consequent differences in benefits and risks patients receiving GA, patients receiving SA had higher between epidurals and SA merit a separate study. The pur- hemoglobin levels on postoperative days 1 and 2 and a 20% pose of this study was to determine whether SA is superior lower total transfusion requirement. SA appears superior to to GA for primary unilateral THA. GA for this procedure. MATERIALS AND METHODS atients undergoing unilateral total hip arthroplasty The study population consisted of all cases of primary (THA) may be offered either regional or general unilateral THA at the Hospital for Joint Diseases between anesthesia (GA).
    [Show full text]
  • Review Course Lectures
    Review Course Lectures International Anesthesia Research Society IARS 2011 REVIEW COURSE LECTURES The material included in the publication has not undergone peer review or review by the Editorial Board of Anesthesia and Analgesia for this publication. Any of the material in this publication may have been transmitted by the author to IARS in various forms of electronic medium. IARS has used its best efforts to receive and format electronic submissions for this publication but has not reviewed each abstract for the purpose of textual error correction and is not liable in any way for any formatting, textual, or grammatical error or inaccuracy. 2 ©2011 International Anesthesia Research Society. Unauthorized Use Prohibited IARS 2011 REVIEW COURSE LECTURES Table of Contents Perioperative Implications of Emerging Concepts In Management of the Malignant Hyperthermia Vascular Aging, Health And Disease Patient In Ambulatory Surgery Charles W. Hogue, MD ..............................1 Denise J. Wedel, MD ...............................38 Professor of Anesthesiology and Professor of Anesthesiology, Mayo Clinic Critical Care Medicine Rochester, Minnesota Chief, Division of Adult Anesthesia The Johns Hopkins University School of Medicine, Central Venous Access Guideline The Johns Hopkins Hospital Development and Recommendations Baltimore, Maryland Stephen M. Rupp, MD ..............................41 Anesthesiologist Perioperative Management of Pain and PONV in Medical Director, Perioperative Services Ambulatory Surgery Virginia Mason Medical Center, Seattle, Washington Spencer S. Liu, MD .................................5 Clinical Professor of Anesthesiology Pediatric Anesthesia and Analgesia Outside the OR: Director of Acute Pain Service What You Need To Know Hospital for Special Surgery Pierre Fiset, MD, FRCPC............................47 New York, New York Department Head, Anesthesiology Montreal Children’s Hospital Colloid or Crystalloid: Any Differences In Outcomes? Montreal, Quebec, Canada Tong J.
    [Show full text]