DOCSLIB.ORG

Nanobiotix Strengthens U.S. Leadership with Appointments of Head of U.S

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Nanobiotix Strengthens U.S. Leadership with Appointments of Head of U.S Nanobiotix Strengthens U.S. leadership with appointments of Head of U.S. Clinical Development and Director of Investor Relations Paris, France and Cambridge, Massachusetts, USA October 3, 2016 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer, today announced that it has strengthened its U.S. leadership team with the appointments of Dr. Mihail Obrocea as the Head of U.S. Clinical Development and Noёl Kurdi as the Director of Investor Relations. These high level profiles will contribute to reinforce Nanobiotix’s presence in the US by strengthening its clinical development and by leveraging US investors potential to continue the growth of the Company. In the US, Nanobiotix has successfully filed its Investigational New Drug application (IND) for NBTXR3 for the treatment of prostate cancer and plans to initiate a Phase I/II trial in three U.S. based oncology sites. In parallel, the Company continues to advance the development its lead product in multiple oncology indications across the world. Nanobiotix incorporated an affiliate in Cambridge in 2014, and opens a new office today in New York City, in order to increase the Company’s visibility and be accessible to the financial community. Dr. Mihail Obrocea joined Nanobiotix from U.S.-based SFJ Pharmaceuticals Group, where he held the position of Vice President of Clinical & Medical Affairs. Previously, he served as Project Director and Oncology Clinical Lead at AbbVie Biotherapeutics Corp., leading multiple Phase I and II oncology and hematology clinical trials. He also held the position of Vice President and Head of Clinical Development Oncology at MannKind Corp. where he brought two cancer vaccines programs into the clinical stages. He has held clinical leadership positions at Sigma-Tau Research and MedImmune. Dr. Obrocea earned his M.D. from the School of Medicine and Pharmacy in Bucharest, Romania. He completed an internal medicine residency at Yale University School of Medicine in Connecticut and completed a hematology / oncology fellowship at Dartmouth Medical School in New Hampshire. Noёl Kurdi joined Nanobiotix from the Trout Group & Trout Capital, where she served as a Senior Associate, providing strategic investor relations counsel to US based and multinational biotech companies seeking access to the US and international capital markets. Previously, Kurdi worked in institutional equity sales and research at Brean Capital, LLC, and held capital markets, business development and investor relations roles at AIG investments. She earned her M.B.A. in finance and marketing from Fordham University and a B.B.A. in international business and marketing from George Washington University. -Ends- About NANOBIOTIX: Nanobiotix (Euronext: NANO / ISIN: FR0011341205) is a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer. The Company’s first-in-class, proprietary technology, NanoXray, enhances radiotherapy energy with a view to provide a new, more efficient treatment for cancer patients. NanoXray products are compatible with current radiotherapy treatments and are meant to treat potentially a wide variety of solid tumors including soft tissue sarcoma, head and neck cancers, liver cancers, prostate cancer, breast cancer, glioblastoma, etc., via multiple routes of administration. Nanobiotix’s lead product NBTXR3, based on NanoXray, is currently under clinical development for soft tissue sarcoma, head and neck cancer, prostate cancer, rectal cancer (PharmaEngine) and liver cancers (HCC and liver metastases). The Company has filed in August 2016 for market approval (CE Marking) in Europe for its lead product NBTXR3. The Company has partnered with PharmaEngine for clinical development and commercialization of NBTXR3 in Asia. 1 Nanobiotix is listed on the regulated market of Euronext in Paris (ISIN: FR0011341205, Euronext ticker: NANO, Bloomberg: NANO: FP). The Company Headquarter is based in Paris, France. Affiliate in Cambridge, United States. For more information, please visit www.nanobiotix.com Contact Nanobiotix Sarah Gaubert Head of Communication and Public Affairs +33 (0)1 40 26 07 55 [email protected] Media relations France - NewCap EU Outside France - Instinctif Partners United States – The Ruth Group Annie-Florence Loyer Melanie Toyne Sewell Kirsten Thomas / Chris Hippolyte +33 (0)6 88 20 35 59 +44 (0) 207 457 2020 +1 508-280-6592 / +1 646-536-7023 [email protected] [email protected] [email protected] Disclaimer This press release contains certain forward-looking statements concerning Nanobiotix and its business. Such forward-looking statements are based on assumptions that Nanobiotix considers to be reasonable. However, there can be no assurance that the estimates contained in such forward-looking statements will be verified, which estimates are subject to numerous risks including the risks set forth in the reference document of Nanobiotix filed with the French Financial Markets Authority (Autorité des Marchés Financiers) under number D.16-0732 on July 22, 2016 (a copy of which is available on www.nanobiotix.com) and to the development of economic conditions, financial markets and the markets in which Nanobiotix operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Nanobiotix or not currently considered material by Nanobiotix. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Nanobiotix to be materially different from such forward-looking statements. This press release and the information that it contains do not constitute an offer to sell or subscribe for, or a solicitation of an offer to purchase or subscribe for, Nanobiotix shares in any country. 2 .
Load more

Recommended publications
  • Radiosensitization by Gold Nanoparticles: Effective at Megavoltage Energies and Potential Role of Oxidative Stress
    Review Article Radiosensitization by gold nanoparticles: effective at megavoltage energies and potential role of oxidative stress Karl T. Butterworth, Stephen J. McMahon, Laura E. Taggart, Kevin M. Prise Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, Northern Ireland, UK Corresponding to: Karl T. Butterworth, Ph.D. Centre for Cancer Research & Cell Biology, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK. Email: [email protected]. Abstract: The multidisciplinary field of nanotechnology has the potential to deliver many novel applications in the biomedical field including improved strategies for the detection, diagnosis and treatment of cancer. In the radiation research arena, gold nanoparticles (GNPs) have demonstrated strong potential as diagnostic imaging agents, drug delivery platforms and radiation sensitizers due to their attractive physico- chemical characteristics. In the pursuit of dose modifiers to improve the therapeutic index of radiotherapy, GNPs have attracted much research interest due to the high atomic number (Z) of gold which results in significantly improved contrast compared to soft tissue. In this review, we consider the physical properties of GNPs which make them widely utilizable in the field of radiation research as image contrast agents, drug delivery vehicles and radiation sensitizers. In particular, we focus on the growing amount of preclinical evidence which demonstrates GNPs as radiation sensitizers and highlight the disparity between observed experimental findings and predictions based on mass attenuation, GNP concentration and beam energy. Considering the large amount of studies performed using a wide range of GNPs, emerging evidence suggests oxidative stress as a central mechanism of radiobiological response. Key Words: Gold nanoparticles (GNPs); radiation; radiosensitizer; image contrast; drug delivery Submitted Apr 29, 2013.
    [Show full text]
  • Combination of First-In-Class NBTXR3, Radiotherapy, and Anti-PD-1 Immunotherapy Demonstrate Efficacy in Treating Resistant Pre-Clinical in Vivo Models of Lung Cancer
    Combination of first-in-class NBTXR3, radiotherapy, and anti-PD-1 immunotherapy demonstrate efficacy in treating resistant pre-clinical in vivo models of lung cancer Data presented at AACR Annual Meeting 2019 • In vivo study conducted alone or in collaboration with The University of Texas MD Anderson Cancer Center demonstrated: o NBTXR3 in combination with a PD-1 inhibitor enhanced an abscopal effect in both sensitive and PD-1-inhibitor-resistant lung cancer models o NBTXR3 in combination with a PD-1 inhibitor showed significant reduction of metastatic load in PD-1-inhibitor- sensitive lung cancer models o NBTXR3 in combination with a CTLA-4 inhibitor enhanced an abscopal effect in colorectal cancer models • Data presented by the Weill Cornell Medical College showed that NBTXR3 mode of action induced interferon (IFN-β) expression in breast cancer cell line • Altogether, the data presented support the ongoing clinical development plan for combinations of NBTXR3 with radiotherapy and immuno-oncology (IO) agents in multiple indications including lung- and head and neck cancers Paris, France; Cambridge, Massachusetts (USA); April 2, 2019 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205 – the ‘‘Company’’) a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced preclinical data from studies currently being conducted under its collaborations with The University of Texas MD Anderson Cancer Center and the Weill Cornell Medical College. These results were presented during two poster sessions at the American Association for Cancer Research (AACR) Annual Meeting 2019, currently taking place in Atlanta, Georgia, USA from March 29 to April 3, 2019. This initial pre-clinical set of NBTXR3/radiotherapy/IO combination data provides further insights into the immune- activation caused by NBTXR3 and strengthens the understanding of the potential systemic effects provided by NBTXR3.
    [Show full text]
  • Laurent Levy, CEO, Increases Stake in Nanobiotix's Capital
    Laurent Levy, CEO, increases stake in Nanobiotix’s capital • Exercising 160,000 BSPCE 2012-1 financed by own funds • Investment of EUR 960,000 to support Nanobiotix’s development • Upward crossing of 5% voting rights threshold Paris, France, and Cambridge, Massachusetts (USA) April 25, 2019 – NANOBIOTIX (Euronext : NANO – ISIN : FR0011341205 – the “Company”), a clinical-stage nanomedicine company pioneering new approaches in the treatment of cancer, announces Laurent Levy’s strengthening position in the Company’s share capital through the exercise of founders’ warrants (bons de souscription de parts de créateur d’entreprise or BSPCE2012-1) granted in 2012, and which exercise period expires on April 25, 2019. In this context, Laurent Levy subscribed to 160,000 new shares through the exercise of 160,000 BSPCE2012-1 for a total amount of EUR 960,000, bringing his ownership to 731,560 shares which represents 3.3% of capital and 5.5% of voting rights of the Company which triggers an upward threshold crossing. “This is an opportunity to participate personally to the financing of the development of Nanobiotix and to keep strengthening my commitment in this project which could potentially help millions of patients around the world.” said Laurent Levy. The Company’s Shareholders Meeting dated May 4, 2012, granted Laurent Levy 1,027,986 BSPCE2012-1, each giving the right to one new ordinary share in the Company at a strike price of EUR 6.00, which the exercise was dependent upon the Company’s share price as well as a minimum volume exchanged. The remaining balance of 867,986 BSPCE2012-1 forfeits at midnight today.
    [Show full text]
  • AACR ANNUAL MEETING 2018: NANOBIOTIX PRESENTED PRECLINICAL DATA SHOWING NBTXR3 NANOPARTICLES CAN ACTIVATE the Cgas-STING PATHWAY
    AACR ANNUAL MEETING 2018: NANOBIOTIX PRESENTED PRECLINICAL DATA SHOWING NBTXR3 NANOPARTICLES CAN ACTIVATE THE cGAS-STING PATHWAY Paris, France and Cambridge, Massachusetts, April 17, 2018 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering new approaches to the local treatment of cancer, today announced that preclinical data evaluating the activation of the cGAS-STING pathway by NBTXR3 has been presented at the American Association for Cancer Research (AACR) Annual Meeting 2018 in Chicago, Illinois (April 14-18, 2018). NBTXR3 is a first-in-class product designed to destroy, when activated by radiotherapy, tumors and metastasis through physical cell death and to induce immunogenic cell death leading to specific activation of the immune system. Establishing how NBTXR3, activated by radiotherapy, impacts and primes the immune response against tumor cells is central to Nanobiotix’s immuno-oncology program. Recently, the cGAS-STING pathway has emerged as the key component of the anti-tumor immune response, along with immunogenic cell death. Therefore, evaluation of the impact of NBTXR3 on this conserved signaling cascade is essential. Dr Elsa Borghi, CMO, commented, “cGAS-STING activation is of fundamental importance in establishing an adaptive anti-tumor immune response. These encouraging preliminary results suggest that NBTXR3 activated by radiotherapy could increase the activation of this pathway, compared to radiotherapy alone.” “Activation of the cGAS-STING pathway by NBTXR3 nanoparticles exposed to radiotherapy” J. Marill, N. Mohamed Anesary, A. Darmon, P. Zhang and S. Paris. Poster number #4571 In this poster, Nanobiotix presents data showing a dose-dependent increase in cGAS-STING pathway activation with NBTXR3 activated by radiotherapy through both in vitro and in vivo analyses.
    [Show full text]
  • Laurent Levy, Président Du Directoire De Nanobiotix Reçoit Le Prix De L’Entrepreneur De L’Université De Buffalo, New York
    Laurent Levy, président du directoire de Nanobiotix reçoit le Prix de l’Entrepreneur de l’Université de Buffalo, New York Ce Prix récompense la démarche entrepreneuriale qui a conduit, en 2003, à la création de Nanobiotix, devenue l’une des sociétés leaders en nanomédecine Paris, le 3 Avril 2013 - L’Université de Buffalo, SUNY, a décerné le 25 mars 2013 le Prix de l’Entrepreneur à Laurent Levy, président du directoire et co-fondateur de Nanobiotix (Euronext: NANO / code ISIN : FR0011341205). Ce Prix est décerné aux entrepreneurs qui, à partir d’une technologie conçue à l’Université de Buffalo, ont créé une entreprise couronnée de succès dont les produits auront un impact bénéfique sur la santé humaine au niveau mondial. Cette année, il récompense la démarche entrepreneuriale qui a donné naissance à Nanobiotix, devenue un leader dans le domaine de la nanomédecine. Les travaux de recherche menés en 1999 par Laurent Levy au sein du laboratoire de Lasers Photoniques et Biophotoniques de l’Université de Buffalo, dirigé par le Pr. Paras N. Prasad, dans le cadre de son post-doctorat en physico-chimie, ont largement contribué au développement de la nanomédecine. Il a notamment développé le concept de nanoparticules activées par champs externes et appliquées à la biologie pour la mise au point de nouveaux traitements. Ce concept a permis de donner naissance à la technologie propriétaire de Nanobiotix – NanoXray-, une approche thérapeutique qui révolutionne le traitement local du cancer en améliorant l’efficacité de la radiothérapie (utilisée pour traiter 60% des patients atteints de cancer), sans augmenter les doses reçues par les tissus sains environnants.
    [Show full text]
  • Nanobiotix Announces the Filing of an Amended Registration Statement, Including an Estimated Initial Public Offering Range
    PRESS RELEASE NANOBIOTIX ANNOUNCES THE FILING OF AN AMENDED REGISTRATION STATEMENT, INCLUDING AN ESTIMATED INITIAL PUBLIC OFFERING RANGE Paris, France; Cambridge, Massachusetts (USA); December 9, 2020 – NANOBIOTIX (Euronext: NANO – ISIN : FR0011341205 – the ‘‘Company’’), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the filing of an amended registration on form F-1 in connection with its intention to issue and sell, subject to market and other conditions, 6,500,000 ordinary shares of the Company in an initial public offering of American Depositary Shares (“ADSs”), each representing the right to receive one ordinary share, in the United States (the “U.S. Offering”) and a concurrent offering of ordinary shares in certain jurisdictions outside the United States to certain investors (the “European Offering” and together with the U.S. Offering, the “Global Offering”). The offering price per ADS is expected to be between $13.50 and $14.50, or between €11.15 and €11.97 per ordinary share (assuming an exchange rate of €1.00 = $1.2109, the exchange rate published by the European Central Bank on December 9, 2020). Assuming an offering price of $14.00 per ADS in the U.S. Offering and €11.56 per ordinary share in the European Offering, which are the midpoints of the respective price ranges, the Company expects to receive net proceeds of approximately $79.6 million (€65.8 million) from the Global Offering. The Company intends to grant the underwriters a 30-day option to purchase, at the same price, additional ADSs and/or ordinary shares in an aggregate amount of up to 15% of the total number of ADSs and ordinary shares proposed to be sold in the Global Offering.
    [Show full text]
  • Corporate Presentation July 2019 1 IMPORTANT NOTICE and DISCLAIMER
    Corporate Presentation July 2019 Corporate Presentation July 2019 1 IMPORTANT NOTICE AND DISCLAIMER IMPORTANT: You must read the following before continuing. In accessing this document, you agree to be bound by the following terms and conditions. References herein to this presentation (this “Presentation”) shall mean and include this document, the oral presentation accompanying this document provided by Nanobiotix SA (together with its subsidiaries, the “Group”), any question and answer session following that oral presentation and any further information that may be made available in connection with the subject matter contained herein (together with the information, statements and opinions contained in this Presentation, the “Information”). This Presentation has been prepared by Nanobiotix SA and is for information purposes only. The Information is provisional and for information purposes only and is not to be construed as providing investment advice. The Information is provided as of the date of this Presentation only and may be subject to significant changes at any time without notice. Neither the Group, nor its advisors, nor any other person is under any obligation to update the Information. Subject to applicable law, none of the Company or its advisors accepts any responsibility whatsoever and makes no representation or warranty, express or implied, as to the fairness, accuracy, completeness or correctness of the Information. The Information has not been subject to independent verification and is qualified in its entirety by the business,
    [Show full text]
  • Press Release
    PRESS RELEASE NANOBIOTIX ANNOUNCES THE APPOINTMENT OF DR. GARY PHILLIPS AS CHAIRMAN OF THE NANOBIOTIX SUPERVISORY BOARD Paris, France; Cambridge, Massachusetts (USA); May 25, 2021 - NANOBIOTIX (Euronext : NANO –– NASDAQ: NBTX – the ‘‘Company’’), a late-clinical stage biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer, today announced that Gary Phillips, MD, has been appointed as the new chairman of the Company’s supervisory board. Dr. Phillips succeeds Laurent Condomine, who will retire from the supervisory board after 11 years of leadership. Dr. Phillips will provide extensive guidance as the Company continues to advance its global development strategy with its planned second clinical registration pathway in head and neck cancer and its immunotherapy pathway as key focus areas. “I am truly honored and excited by my appointment as chairman of the Nanobiotix supervisory board,” said Dr. Phillips. “I look forward to working with the board and the entire organization toward delivering the breakthrough promise of its potentially transformational technology. Overcoming cancer and other major diseases is an absolute necessity for patients, their families and health care providers, and I believe we have the opportunity to expand treatment possibilities for their benefit.” Dr. Phillips, who is currently president and chief executive officer of OrphoMed, Inc. (OrphoMed), in the United States, brings decades of experience in the pharmaceutical and healthcare industries where he has led commercial operations, clinical medicine, business strategy, and development functions. Before joining OrphoMed in 2018, Dr. Phillips worked with Mallinckrodt Pharmaceuticals, where he had served as Executive Vice President and Chief Strategy Officer since 2013.
    [Show full text]
  • Nanobiotix Secures Financing from a US Major Investor to Address The
    Small but heading for the big time Nanobiotix secures financing from a major US investor, to address the US market Plans announced to develop NBTXR3 in new indications with a global approach across Europe, Asia and now the United States Registration of the reference document Paris, France, 25 November, 2014 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205) , a clinical- stage nanomedicine company pioneering novel approaches for the local treatment of cancer, announced today (i) the completion of a private placement with Capital Ventures International (“CVI”) of new shares with warrants attached for a total amount of € 10,393,500, which may be supplemented by an amount of up to € 14,059,500 in case of exercise of all the warrants, (ii) CVI’s commitment to purchase an additional tranche of up to € 10 million that the Company may issue in its discretion (subject to any required corporate authorizations) under the terms and conditions described below, (iii) the Company’s new global development plan and (iv) the registration with the French Autorité des marchés financiers (AMF) of the Company’s reference document, which has been updated with the information relating to the Company’s business to date. • Nanobiotix is now in position to expand its clinical development program and intends to develop new high potential indications in both US and EU, in parallel with the soft tissue sarcoma registration clinical trial and Head and Neck cancer trial already underway in Europe. • In order to preserve both the company’s and its shareholders’ interests, Nanobiotix intention is to realize a higher value, before seeking a potential partnership for the US market.
    [Show full text]
  • Nanobiotix Announces Trading Resumption of Its Ordinary Shares on Euronext Paris
    PRESS RELEASE NANOBIOTIX ANNOUNCES TRADING RESUMPTION OF ITS ORDINARY SHARES ON EURONEXT PARIS Paris, France; Cambridge, Massachusetts (USA); December 11, 2020 – NANOBIOTIX (Euronext: NANO – ISIN : FR0011341205 – the ‘‘Company’’), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, announced the trading resumption of its ordinary shares on Euronext in Paris (“Euronext Paris”) as from 4:00 pm CET. Trading in the ordinary shares of Nanobiotix was halted at the request of the Company on December 11, 2020 from 9:00 am CET in connection with its previously announced global offering, in order to allow for the confirmation of allocations to investors and for the commencement of trading of the Company’s American Depositary Shares on the Nasdaq Global Select Market. About NANOBIOTIX Incorporated in 2003, Nanobiotix is a leading, clinical-stage nanomedicine company pioneering new approaches to significantly change patient outcomes by bringing nanophysics to the heart of the cell. The Nanobiotix philosophy is rooted in designing pioneering, physical-based approaches to bring highly effective and generalized solutions to address unmet medical needs and challenges. Nanobiotix’s novel, proprietary lead technology, NBTXR3, aims to expand radiotherapy benefits for millions of cancer patients. Nanobiotix’s Immuno-Oncology program has the potential to bring a new dimension to cancer immunotherapies. Nanobiotix is listed on the regulated market of Euronext in Paris (Euronext: NANO / ISIN: FR0011341205; Bloomberg: NANO: FP). Its headquarters are in Paris, France. Nanobiotix has a subsidiary, Curadigm, located in France and the United States, as well as a US affiliate in Cambridge, MA, and European affiliates in France, Spain and Germany.
    [Show full text]
  • Nanobiotix Recrute Un Senior Executive De L'industrie Pharmaceutique Au
    Nanobiotix recrute un senior executive de l’industrie pharmaceutique au poste de Chief Operating Officer Spécialisé en oncologie, il dirigera les opérations et la commercialisation du produit NBTXR3 Paris, France, et Cambridge, Massachusetts, USA, 7 février, 2017 – NANOBIOTIX (Euronext: NANO – ISIN: FR0011341205), société française pionnière en nanomédecine développant de nouvelles approches thérapeutiques pour le traitement local du cancer, annonce aujourd’hui le recrutement d’Alain Dostie, en tant que Chief Operating Officer (COO). Alain Dostie dirigera les opérations de Nanobiotix. Ces activités incluent le développement clinique, la production, l’accès au marché et la commercialisation de NBTXR3 dont le marquage CE pourrait être obtenu en 2017. Précédemment, Alain Dostie était le « General Manager » de la division Oncologie de Novartis en Allemagne. Il rejoint Nanobiotix riche de plus de 25 ans d’expérience internationale dans l’industrie pharmaceutique, et particulièrement en accès au marché et en oncologie. Laurent Levy, CEO de Nanobiotix a commenté : « Nous sommes très heureux d’accueillir Alain dans notre équipe. Au moment où Nanobiotix s’apprête à changer de dimension, son expérience, son remarquable parcours et ses valeurs font de lui la bonne personne à ce poste stratégique. » Alain Dostie, COO de Nanobiotix a ajouté : « Nanobiotix est à un moment clé dans sa création de valeur, cette année sont attendues l’analyse intermédiaire de sa première phase II/III et une potentielle première autorisation de mise sur le marché, c’est très excitant ! La technologie développée par Nanobiotix est unique, largement applicable et portée par une équipe solide et enthousiaste, je les rejoins aujourd’hui pour contribuer à la réussite à long terme de la Société.
    [Show full text]
  • Press Release Nanobiotix Announces First Patient Injected with Nbtxr3 in Esophageal Cancer
    PRESS RELEASE NANOBIOTIX ANNOUNCES FIRST PATIENT INJECTED WITH NBTXR3 IN ESOPHAGEAL CANCER First patient injected in phase I trial evaluating tumor-agnostic NBTXR3 activated by radiation therapy with concurrent chemotherapy for patients with esophageal cancer This first injection expands evaluation of NBTXR3 to its seventh indication either as a single agent activated by radiotherapy or in combination with other anti-cancer therapies, including immune checkpoint inhibitors and chemotherapy This trial is executed within the scope of an existing clinical collaboration agreement and does not represent incremental costs for the company beyond previously announced financial terms “We believe that NBTXR3 could have a positive impact for patients with cancer in any case where radiotherapy is a part of the standard of care. Expansion into esophageal cancer represents not only another step toward achieving our goals, it also highlights the ongoing progress of our clinical collaboration agreement with The University of Texas MD Anderson Cancer Center.” – Laurent Levy, CEO of Nanobiotix Paris, France ; Cambridge, Massachusetts (USA) ; January 28, 2021 - NANOBIOTIX (Euronext: NANO – NASDAQ: NBTX – the ‘‘Company’’), a clinical-stage biotechnology company focused on developing first-in- class product candidates that use proprietary nanotechnology to transform the treatment of cancer, today announced that the first patient has been injected in a phase I study evaluating tumor-agnostic NBTXR3 activated by radiation therapy with concurrent chemotherapy for patients with esophageal cancer. The trial is being conducted at The University of Texas MD Anderson Cancer Center (MD Anderson) as part of an ongoing clinical collaboration. Background and Opportunity According to the World Health Organization, esophageal cancer is currently the sixth most common cause of cancer death in the world and is estimated to have caused over 508,585 deaths in 2018.
    [Show full text]