2015 Annual Report PROFILE
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UCB SA (Incorporated with Limited Liability in Belgium) As Issuer
Base Prospectus dated 8 March 2021 UCB SA (incorporated with limited liability in Belgium) as Issuer EUR 5,000,000,000 Euro Medium Term Note Programme Due from one month from the date of original issue This base prospectus (the “Base Prospectus”) relating to the EUR 5,000,000,000 Euro Medium Term Note Programme (the “Programme”) of UCB SA, a limited liability company (société anonyme) incorporated under the laws of Belgium, having its registered office at Allée de la Recherche 60, B-1070 Brussels and registered with the Crossroads Bank for Enterprises under number 0403.053.608 (“UCB”, or the “Issuer”) is valid, for the purpose of the admission to trading and listing of the Notes (as defined below) on the regulated market of Euronext Brussels or on another regulated market in the European Economic Area (the “EEA”), for a period of twelve months from the date of approval. Any Notes issued under the Programme are issued subject to the provisions set out herein. Under the Programme, the Issuer, subject to compliance with all relevant laws, regulations and directives, may from time to time issue Euro Medium Term Notes (the “Notes”) as may be agreed between the Issuer and the relevant Dealer (as defined below). The minimum Specified Denomination of Notes shall be EUR 100,000 (or its equivalent in other currencies).The maximum aggregate nominal amount of Notes outstanding will not at any time exceed EUR 5,000,000,000 (or the equivalent in other currencies). This Base Prospectus has been approved as a base prospectus for the purposes of Article 8 of Regulation 2017/1129 (as amended, the “Prospectus Regulation”) on 8 March 2021 by the Belgian Financial Services and Markets Authority (the “FSMA”) in its capacity as competent authority in accordance with Article 20 of the Prospectus Regulation. -
Integrated Annual Report 2020
Amber, living with psoriasis INTEGRATED ANNUAL REPORT 2020 ADAPTING FOR BETTER CARE INTEGRATED ANNUAL REPORT 2020 ADAPTING FOR BETTER CARE Welcome to our Integrated Annual Report 2020! Our Integrated Annual Report 2020 – Adapting for Better Care – aims to provide all interested stakeholders with the best pos- sible information on how UCB is creating value for patients with severe diseases and about how we care for our employees, for communities, and for our planet, now and into the future. About this report This Integrated Annual Report 2020 includes the management report in accordance with article 12 of the Royal Decree of 14 November 2007 relating to the obligations of issuers of finan- cial instruments admitted to trading on a regulated market. All information required to be included in such management report pursuant to articles 3:6 and 3:32 of the Belgian Code of Com- panies and Associations (i.e. Corporate Governance Statement – Remuneration Report included -, Business Performance Review and UCB’s Statement on extra-financial1 information) is reported throughout all different sections of this Integrated Annual Re- port. This Integrated Annual Report together with the materiality assessment have been prepared in accordance with the Global Reporting Standards core option and extra-financial information is audited by a third party. 1 ‘Extra-financial’ is the term used by UCB for information commonly referred to as ‘non-financial’. UCB | Integrated Annual Report 2020 3 Index Key Figures 6 UCB At a Glance 8 Letter to our stakeholders -
Solvay Process Company and a Portion of the Village of Solvay Which Grew up Company to Use Their Process
:«:..' :•' Telephone 2-3111 Telephone 2-3111 SYRACUSE JOTJRNAIi Saturday, July 28, 193C Page 8 - SOLVAY PROCESS AMONG STATE'S MIGHTIEST PLANTS MUM) NIK BURNS BRIGHTLY AIRVIEW OF THE SOLVAY PROCESS PLANT WHICH GREW FROM WILLIAM COGSWELL'S IDEA N HISTORY OF VAST IRKS j (This is the fifth of a series of articles whhb willjg <«.»r weklv in the Saturday edition of The Syracuse • ^ourZ^topermitSyracusaJto become iamiliar with the journal, to P"™;*' industrial and commercial enter- inside story of the great industrial a™ * develoo- \ prises which have played important parts in the develop lent of the city.) _ By BICHAKD B. WELCH. Bountiful Nature which supplied Syracuse with huge qnan- Itie* of salt and limestone coupled with the lewdness 0£ a Central New Yorker who saw the l-kto»tta.-* •btainahle raw materials gave Syracuse the.S*j'««- r^™*™™ ATIP of the largest heavy industries in the state. C°T^»M£nk of the history of the Solvay Process r™J»,»T« * subsidiary of the Allied Chemical and Dye Corp- STCE* tSTo William Browne Cog^eUmw, brain tie idea' of utilizing the resources of this section first KenXhdcredit for the formation and progress' »* tfe ^|My industry must also go to Bow and1 Hazard first P^nt tfthe company, and his son, Frederick B. Hazard, who succeeded him. SH; names which burn brightly in the industrial history 01 SMrCCog^ell was born in Oswego, Sept 22,1834 of a lixie- ,ge which dated back to Sir John Cogswell in If5- He was educated in Hamilton Academy at Oneida and in private schools of Syracuse. -
Dynavax Announces Full Enrollment of Phase II/III AIC Trial
Dynavax Announces Full Enrollment of Phase II/III AIC Trial BERKELEY, Calif., May 19 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation (Nasdaq: DVAX), a biopharmaceutical company focused on the discovery, development, and commercialization of innovative products to treat and prevent allergies, infectious diseases and chronic inflammatory diseases, today announced that its Phase II/III clinical trial of AIC for ragweed allergy, which started in late February 2004, has been fully enrolled. The double blind, placebo controlled study involves 462 subjects at 30 sites in the U.S. and will be completed over the next 18 months. The immunization schedule, consisting of six injections over six weeks, will be completed by June. The clinical trial is being conducted in collaboration with UCB Pharma, a European pharmaceutical company that markets XYZAL® and developed ZYRTEC®, the leading prescription anti- allergy drug worldwide. Dynavax and UCB signed a global licensing and commercialization agreement covering ragweed and grass allergy immunotherapies in February 2004. The primary endpoint of the Phase II/III ragweed study will be nasal symptoms scores after the second ragweed season in the late summer and early fall of 2005, with secondary endpoints assessing symptoms, medication use and quality of life in both the first and second year. A blinded interim analysis will be made in late 2004 to assess safety and the appropriateness of commencing a one-year Phase III trial in early 2005. "The collaboration with UCB has been very effective, with both organizations working diligently to advance our ragweed program," said Dr. Dino Dina, president and CEO of Dynavax. "The rapid enrollment of our ragweed trial, particularly given its size and stringent enrollment criteria, is an early indication of the level of interest that both investigators and patients have in this therapy. -
Lamotrigine Orally Disintegrating Tablet
UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2021 P 3001-14 Program Step Therapy - Anticonvulsants Medication/Therapeutic Anticonvulsants – Class Depakote®, Depakote ER®, Felbatol, Keppra® , Keppra® XR®, Lamictal®, Lamictal XR®, Lamictal ODT®, lamotrigine extended-release, lamotrigine orally disintegrating tablet, Lyrica, Mysoline, Neurontin®, Onfi, Oxtellar™ XR*, Qudexy XR* (brand and authorized generic), Sabril, Spritam*, Topamax®, Trileptal®, Trokendi® XR*, Zonegran® P&T Approval Date 8/2010, 11/2010, 11/2011, 2/2013, 11/2013, 4/2014, 7/2014, 11/2014, 4/2015, 1/2016, 6/2016, 6/2017, 9/2018, 9/2019, 10/2020, 6/2021 Effective Date 9/1/2021; Oxford only: N/A 1. Background Step Therapy programs are utilized to encourage use of lower cost alternatives for certain therapeutic classes. a. Multi-Source Brand Products This program requires a member to try the A-rated generic prior to receiving coverage for Depakote, Depakote ER, Felbatol, Keppra, Keppra XR, Lamictal, Lamictal ODT, Lamictal XR, Lyrica, Mysoline, Neurontin, Onfi, Sabril, Topamax, Trileptal and Zonegran. There will be exceptions for members with a documented diagnosis of a seizure disorder. For members with a claim for at least a 14 day supply of the A-rated generic in the previous 6 months, the prescription will process automatically. b. Modified Release Products This program requires a member to try levetiracetam immediate release, levetiracetam extended-release, levetiracetam solution, lamotrigine immediate release, divalproex sodium delayed release, Depakote delayed release, generic valproic acid, Depakene formulations, Depakote sprinkles, divalproex sodium sprinkles, oxcarbazepine or Trileptal prior to coverage of their respective modified release formulations: lamotrigine extended-release, lamotrigine orally disintegrating tablet, Oxtellar XR*, Qudexy XR*, Spritam and Trokendi XR*. -
Portfolio of Investments
PORTFOLIO OF INVESTMENTS Variable Portfolio – Partners International Value Fund, September 30, 2020 (Unaudited) (Percentages represent value of investments compared to net assets) Investments in securities Common Stocks 97.9% Common Stocks (continued) Issuer Shares Value ($) Issuer Shares Value ($) Australia 4.2% UCB SA 3,232 367,070 AMP Ltd. 247,119 232,705 Total 13,350,657 Aurizon Holdings Ltd. 64,744 199,177 China 0.6% Australia & New Zealand Banking Group Ltd. 340,950 4,253,691 Baidu, Inc., ADR(a) 15,000 1,898,850 Bendigo & Adelaide Bank Ltd. 30,812 134,198 China Mobile Ltd. 658,000 4,223,890 BlueScope Steel Ltd. 132,090 1,217,053 Total 6,122,740 Boral Ltd. 177,752 587,387 Denmark 1.9% Challenger Ltd. 802,400 2,232,907 AP Moller - Maersk A/S, Class A 160 234,206 Cleanaway Waste Management Ltd. 273,032 412,273 AP Moller - Maersk A/S, Class B 3,945 6,236,577 Crown Resorts Ltd. 31,489 200,032 Carlsberg A/S, Class B 12,199 1,643,476 Fortescue Metals Group Ltd. 194,057 2,279,787 Danske Bank A/S(a) 35,892 485,479 Harvey Norman Holdings Ltd. 144,797 471,278 Demant A/S(a) 8,210 257,475 Incitec Pivot Ltd. 377,247 552,746 Drilling Co. of 1972 A/S (The)(a) 40,700 879,052 LendLease Group 485,961 3,882,083 DSV PANALPINA A/S 15,851 2,571,083 Macquarie Group Ltd. 65,800 5,703,825 Genmab A/S(a) 1,071 388,672 National Australia Bank Ltd. -
205836Orig1s000 205837Orig1s000 205838Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 205836Orig1s000 205837Orig1s000 205838Orig1s000 ADMINISTRATIVE and CORRESPONDENCE DOCUMENTS EXCLUSIVITY SUMMARY NDA #: NDA 205836 (oral tablets), NDA 205837 (injection 10 mg/mL) NDA 205838 (oral solution 10 mg/mL) SUPPL # HFD # Trade Name: BRIVIACT Generic Name: BRIVIACT (brivaracetam); 10, 25, 50, 75, and 100 mg oral tablets; injection (10 mg/mL); and oral solution (10 mg/mL) Applicant Name: UCB, Inc. Approval Date, If Known: February 19, 2016 PART I IS AN EXCLUSIVITY DETERMINATION NEEDED? 1. An exclusivity determination will be made for all original applications, and all efficacy supplements. Complete PARTS II and III of this Exclusivity Summary only if you answer "yes" to one or more of the following questions about the submission. a) Is it a 505(b)(1), 505(b)(2) or efficacy supplement? YES X NO If yes, what type? Specify 505(b)(1), 505(b)(2), SE1, SE2, SE3,SE4, SE5, SE6, SE7, SE8 505(b)(1) c) Did it require the review of clinical data other than to support a safety claim or change in labeling related to safety? (If it required review only of bioavailability or bioequivalence data, answer "no.") YES X NO If your answer is "no" because you believe the study is a bioavailability study and, therefore, not eligible for exclusivity, EXPLAIN why it is a bioavailability study, including your reasons for disagreeing with any arguments made by the applicant that the study was not simply a bioavailability study. If it is a supplement requiring the review of clinical data but it is not an effectiveness supplement, describe the change or claim that is supported by the clinical data: Reference ID: 3888400 Page 1 d) Did the applicant request exclusivity? YES X NO New moiety exclusivity requested If the answer to (d) is "yes," how many years of exclusivity did the applicant request? Applicant did not specify. -
Celltech, a Sound Strategic Acquisition Neutral
UCB 8 June 2004 Celltech, a sound strategic acquisition Pharmaceuticals & Biotechnology Current price € 39.90 Neutral Belgium Target price € 42.00 Rating unchanged 118 FY/e 31.12 2003 2004E 2005E 2006E 40 Sales (€ m) 2,966 3,107 3,492 3,885 110 36 EBITDA (€ m) 647 672 810 948 102 Pre-Tax* (€ m) 485 453 486 621 32 94 Adj EPS* (€) 2.32 2.21 2.46 3.09 28 86 EPS (€) 2.32 1.83 1.70 2.32 DPS (€) 0.82 0.85 0.88 0.92 24 78 P/E* (x) 17.2 18.1 16.2 12.9 20 70 Yield (%) 2.1 2.1 2.2 2.3 JJSONJFMM Price Rel. to index (RHS) EV/EBITDA (x) 9.2 12.1 10.1 8.7 Source: Thomson Financial Datastream Source: KBC Securities *Adjusted for goodwill and exceptionals Reuters UCBBt.BR Bloomberg UCB BB UCB’s share price hasn’t stopped soaring since the www.ucb-group.com acquisition of Celltech. Although we are positive about this Market Cap € 5,823m strategic acquisition, we think that the upside potential is Shares outst. 145.9m now virtually exhausted. Volume (daily) € 10.6m Free float 59% • From a strategic standpoint, Celltech’s acquisition is an enormous step forward, reinforcing UCB’s Pharma pipeline Next corporate event and management team. But the road to positive returns is General Assembly FY03 on 8 June 2004 still long and risky, so UCB still deserves a discount to Performance over 1m 3m 12m average Pharma ratios. Absolute 14% 31% 45% In technical terms, the merger should be positive as the Rel. -
Opteon-1100-Appliance-Brochure.Pdf
Opteon™ 1100 Foam Blowing Agent Increased Performance and Reduced Environmental Impact to Meet the Needs of the Appliance Industry Opteon™ 1100 Foam Blowing Agent Continuing Innovation Chemical Stability in Foam Systems Chemours continues to expand its foam blowing agent (FBA) Opteon™ 1100 offers best-in-class stability across a broad offerings to the market with next generation solutions. In range of foam systems. As shown in Tables 2 and 3, response to the appliance industry’s growing need for high hand-mix foams prepared from Opteon™ 1100 foam performance products with reduced environmental impact, systems stored at 50 °C (122 °F) for 6 months indicated Chemours has developed a new innovation: Opteon™ 1100. no increase in reactivity or density. This chemical stability is unique to Opteon™ 1100 and provides the required Easy to Convert shelf-life for foam systems that must remain flexible and Based on hydrofluoro-olefin chemistry, Opteon™ 1100 economically viable in a variety of operations. provides the desired physical properties and performance Table 2. Opteon™ 1100 Stability in Polyether System— characteristics as a liquid blowing agent when compared 6 Months Storage at 50 °C (122 °F) with HCFCs, HFCs, and HCs. From its optimal boiling point Ratio (Tack to its low vapor thermal conductivity and low permeation, Days at 50 °C Cream Time Tack Free Free/Cream Foam Density Opteon™ 1100 allows its users to easily convert their in Oven (sec) (sec) Time) (pcf) equipment to a more sustainable solution. Opteon™ 1100 0 25 90 3.6 2.1 also has the added benefit of being nonflammable with a 4 20 90 4.5 2.2 favorable toxicity profile. -
International the News Magazine of IUPAC
CHEMISTRY International The News Magazine of IUPAC November-December 2013 Volume 35 No. 6 A Look Back at Ernest Solvay InChI, the Chemical Identifier INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY Suffixes and the Naming of Elements From the Editor A Heartfelt Congratulations to OPCW CHEMISTRY International n 11 October 2013, the Norwegian Nobel Committee announced that The News Magazine of the International Union of Pure and Othis year’s Nobel Peace Prize will be awarded to the Organization for Applied Chemistry (IUPAC) the Prohibition of Chemical Weapons (OPCW) for its extensive efforts to eliminate chemical weapons. www.iupac.org/publications/ci This is a great and important recognition for an organization that works so diligently to make the world a safer place. I am humbled to Managing Editor: Fabienne Meyers relay IUPAC’s heartfelt congratulations to our Production Editor: Chris Brouwer OPCW colleagues for this fantastic and well- Design: pubsimple deserved recognition for their tireless work to free the world of chemical weapons. All correspondence to be addressed to: In recent years, IUPAC has been privileged Fabienne Meyers to work with OPCW, both in contributing IUPAC, c/o Department of Chemistry technical expertise to the review conferences Boston University of the Chemical Weapons Convention (CWC) Metcalf Center for Science and Engineering and in developing educational resources on the multiple uses of chemi- 590 Commonwealth Ave. cals. As recently as the July-Aug 2013 issue of Chemistry International, Boston, MA 02215, USA Leiv K. Sydnes contributed a feature outlining IUPAC’s involvement with OPCW over the last 12 years. That feature was triggered by the recent E-mail: [email protected] IUPAC Technical Report (in the April 2013 Pure and Applied Chemistry) Phone: +1 617 358 0410 titled “Impact of Scientific Developments on the Chemical Weapons Fax: +1 617 353 6466 Convention,” released in advance of the Third Review Conference of the CWC held last April. -
Branding Brussels Musically: Cosmopolitanism and Nationalism in the Interwar Years
BRANDING BRUSSELS MUSICALLY: COSMOPOLITANISM AND NATIONALISM IN THE INTERWAR YEARS Catherine A. Hughes A dissertation submitted to the faculty at the University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Music. Chapel Hill 2015 Approved by: Annegret Fauser Mark Evan Bonds Valérie Dufour John L. Nádas Chérie Rivers Ndaliko © 2015 Catherine A. Hughes ALL RIGHTS RESERVED ii ABSTRACT Catherine A. Hughes: Branding Brussels Musically: Cosmopolitanism and Nationalism in the Interwar Years (Under the direction of Annegret Fauser) In Belgium, constructions of musical life in Brussels between the World Wars varied widely: some viewed the city as a major musical center, and others framed the city as a peripheral space to its larger neighbors. Both views, however, based the city’s identity on an intense interest in new foreign music, with works by Belgian composers taking a secondary importance. This modern and cosmopolitan concept of cultural achievement offered an alternative to the more traditional model of national identity as being built solely on creations by native artists sharing local traditions. Such a model eluded a country with competing ethnic groups: the Francophone Walloons in the south and the Flemish in the north. Openness to a wide variety of music became a hallmark of the capital’s cultural identity. As a result, the forces of Belgian cultural identity, patriotism, internationalism, interest in foreign culture, and conflicting views of modern music complicated the construction of Belgian cultural identity through music. By focusing on the work of the four central people in the network of organizers, patrons, and performers that sustained the art music culture in the Belgian capital, this dissertation challenges assumptions about construction of musical culture. -
The Ultimate Guide to the More Than Five Famous Belgians a Journey
The ultimate guide to the more than five famous Belgians A journey across Brussels & the South of Belgium – Episode 1 Rue St André, Brussels © Jeanmart.eu/belgiumtheplaceto.be When a Belgian arrives in the UK for the delighted to complete in the near future first time, he or she does not necessarily (hence Episode I in the title). We Belgians expect the usual reaction of the British when are a colourful, slightly surreal people. they realise they are dealing with a Belgian: We invented a literary genre (the Belgian “You’re Belgian? Really?... Ha! Can you name strip cartoon) whose heroes are brilliant more than five famous Belgians?.” When we ambassadors of our vivid imaginations and then start enthusiastically listing some of of who we really are. So, with this Episode 1 our favourite national icons, we are again of Did you say Famous Belgians!? and, by surprised by the disbelieving looks on the presenting our national icons in the context faces of our new British friends.... and we of the places they are from, or that better usually end up being invited to the next illustrate their achievements, we hope to game of Trivial Pursuit they play with their arouse your curiosity about one of Belgium’s friends and relatives! greatest assets – apart, of course, from our beautiful unspoilt countryside and towns, We have decided to develop from what riveting lifestyle, great events, delicious food appears to be a very British joke a means and drink, and world-famous chocolate and of introducing you to our lovely homeland. beer - : our people! We hope that the booklet Belgium can boast not only really fascinating will help you to become the ultimate well- famous characters, but also genius inventors informed visitor, since..