Prevalence, Seroconversion and Mother-To-Child Transmission of Dual
Eleje et al. Reproductive Health (2020) 17:144 https://doi.org/10.1186/s12978-020-00995-8 STUDY PROTOCOL Open Access Prevalence, seroconversion and mother-to- child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol George Uchenna Eleje1,2* , Ikechukwu Innocent Mbachu1,2 , Uchenna Chukwunonso Ogwaluonye3 , Stephen Okoroafor Kalu4 , Chinyere Ukamaka Onubogu5 , Sussan Ifeyinwa Nweje6 , Chinwe Elizabeth Uzochukwu7 , Chike Henry Nwankwo8 , Preye Owen Fiebai9,10 , Olabisi Morebise Loto11,12 , Godwin Otuodichinma Akaba13,14 , Hadiza Abdullahi Usman15,16 , Ayyuba Rabiu17,18 , Richard Obinwanne Egeonu2 , Odion Emmanuel Igue19 , Bukola Abimbola Adesoji20 , Chiamaka Henrietta Jibuaku3 , Prince Ogbonnia Aja21 , Chiamaka Perpetua Chidozie21 , Hadiza Sani Ibrahim18 , Fatima Ele Aliyu18 , Aisha Ismaila Numan16 , Ogbonna Dennis Okoro22 , Solace Amechi Omoruyi10 , Ijeoma Chioma Oppah10 , Ubong Inyang Anyang14 , Aishat Ahmed14 , Shirley Nneka Chukwurah23, Osita Samuel Umeononihu1,2 , Rebecca Chinyelu Chukwuanukwu21 , Eric Okechukwu Umeh24 , Ekene Agatha Emeka25 , Chukwuanugo Nkemakonam Ogbuagu26 , Ibrahim Adamu Yakasai17,18 , Oliver Chukwujekwu Ezechi27 , Joseph Ifeanyichukwu Ikechebelu1,2 and Triplex infection in pregnancy collaboration group Abstract Background: Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives: To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria.
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