Dietary Manganese, Plasma Markers of Inflammation, and The
1344 Diabetes Care Volume 43, June 2020 Jung Ho Gong,1,2 Kenneth Lo,1–3 Qing Liu,1,2 Dietary Manganese, Plasma Jie Li,1–3 Shuiqing Lai,1–3 fl Aladdin H. Shadyab,4 Chrisa Arcan,5 Markers of In ammation, and the Linda Snetselaar,6 and Simin Liu1,2,7 Development of Type 2 Diabetes in Postmenopausal Women: Findings From the Women’s Health Initiative Diabetes Care 2020;43:1344–1351 | https://doi.org/10.2337/dc20-0243 1Department of Epidemiology, Brown University, Providence, RI OBJECTIVE 2Center for Global Cardiometabolic Health, Brown To examine the association between manganese intake and the risk of type 2 University, Providence, RI 3 diabetes in postmenopausal women and determine whether this association is Department of Cardiology, Guangdong Cardio- fl vascular Institute, Hypertension Research Labo- mediated by circulating markers of in ammation. ratory, Guangdong Provincial People’s Hospital, Guangdong Provincial Key Laboratory of Coro- RESEARCH DESIGN AND METHODS nary Heart Disease Prevention, Guangdong Acad- We included 84,285 postmenopausal women without a history of diabetes from the emy of Medical Sciences, South China University national Women’s Health Initiative Observational Study (WHI-OS). Replication of Technology School of Medicine, Guangzhou, China analysis was then conducted among 62,338 women who participated in the WHI- 4Department of Family Medicine and Public Clinical Trial (WHI-CT). Additionally, data from a case-control study of 3,749 women Health, University of California San Diego School nested in the WHI-OS with information on biomarkers of inflammation and of Medicine, La Jolla, CA 5 endothelial dysfunction were examined using mediation analysis to determine the Department of Family, Population, and Preven- tive Medicine, Renaissance School of Medicine, relative contributions of these known biomarkers by which manganese affects Stony Brook University, Stony Brook, NY type 2 diabetes risk.
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