Human Natural Killer Cells Control Plasmodium Falciparum Infection by Eliminating Infected Red Blood Cells
Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells Qingfeng Chena,b, Anburaj Amaladossa, Weijian Yea,c, Min Liua, Sara Dummlera, Fang Konga, Lan Hiong Wonga, Hooi Linn Looa, Eva Lohd, Shu Qi Tane, Thiam Chye Tane,f, Kenneth T. E. Changd,f, Ming Daoa,g,1, Subra Sureshh,i,1, Peter R. Preisera,c,1, and Jianzhu Chena,j,k,1 aInterdisciplinary Research Group in Infectious Diseases, Singapore-MIT Alliance for Research and Technology, Singapore 138602; bHumanized Mouse Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673; cSchool of Biological Sciences, Nanyang Technological University of Singapore, Singapore 637551; Departments of dPathology and Laboratory Medicine and eObstetrics and Gynaecology, KK Women’s and Children’s Hospital, Singapore 229899; fDuke-National University of Singapore Graduate Medical School, Singapore 169857; Departments of gMaterials Science and Engineering and kBiology and jKoch Institute for Integrative Cancer Research Massachusetts Institute of Technology, Cambridge, MA 02139; and Departments of hMaterials Science and Engineering and iBiomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213 Contributed by Subra Suresh, December 16, 2013 (sent for review October 25, 2013) Immunodeficient mouse–human chimeras provide a powerful human RBCs led to reproducible transition from liver-stage in- approach to study host-specific pathogens, such as Plasmodium fection to blood-stage infection (6). Despite such progress, none of falciparum that causes human malaria. Supplementation of im- the existing mouse models of human parasite infection has a human munodeficient mice with human RBCs supports infection by hu- immune system. man Plasmodium parasites, but these mice lack the human immune The immune system plays a critical role in the control of par- system.
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