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Pregnancy Research Review: Data and Methods Report

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Pregnancy Research Review: Data and Methods Report EUROPE SUSAN GUTHRIE, CATHERINE A. LICHTEN, BRANDI LEACH, JACK POLLARD, SARAH PARKINSON, MARLENE ALTENHOFER Pregnancy research review Data and methods report For more information on this publication, visit www.rand.org/t/RR4340 Published by the RAND Corporation, Santa Monica, Calif., and Cambridge, UK © Copyright 2020 RAND Corporation R® is a registered trademark. RAND Europe is a not-for-profit research organisation that helps to improve policy and decision making through research and analysis. RAND’s publications do not necessarily reflect the opinions of its research clients and sponsors. Limited Print and Electronic Distribution Rights This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited. Permission is given to duplicate this document for personal use only, as long as it is unaltered and complete. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial use. For information on reprint and linking permissions, please visit www.rand.org/pubs/permissions. Support RAND Make a tax-deductible charitable contribution at www.rand.org/giving/contribute www.rand.org www.randeurope.org Preface This report sets out the results of a study – commissioned by the UK Clinical Research Collaboration – that aimed to characterise the pregnancy-research landscape in the UK, assess the level of funding for pregnancy research in the UK, and understand the extent to which funded research addresses the research priorities identified by stakeholders. This data and methods report sets out the methods used for the study, and presents in detail the results of the study and the data it produced. It is accompanied by a policy report that focuses on presenting the key policy-relevant messages emerging from the work. This report is likely to be of interest to research funders and those working in research related to pregnancy. For more information about this report, or RAND Europe, please contact: Dr Susan Guthrie RAND Europe, Westbrook Centre, Milton Road Cambridge CB4 1YG +44 (1223) 353329 [email protected] iii Table of contents Preface .................................................................................................................................................... iii Figures .................................................................................................................................................... vi Tables ..................................................................................................................................................... xi Abbreviations ......................................................................................................................................... xii Acknowledgements ............................................................................................................................... xiv 1. Introduction ................................................................................................................................. 1 1.1. Context and aims ....................................................................................................................... 1 1.2. Structure and purpose of this report ........................................................................................... 2 2. Methods ........................................................................................................................................ 3 2.1. Task A: Funding analysis ........................................................................................................... 4 2.2. Task B: Contextualisation of research spend ............................................................................. 18 2.3. Task C: Research priority setting .............................................................................................. 25 3. Task A results: Funding analysis ................................................................................................. 33 3.1. Overall spending and number of awards ................................................................................... 33 3.2. Core funding analysis ............................................................................................................... 35 3.3. NIHR data ............................................................................................................................... 51 3.4. Industry data ............................................................................................................................ 67 4. Task B results: Contextualisation of research spend .................................................................... 72 4.1. Introduction ............................................................................................................................ 72 4.2. Costs associated with poor pregnancy outcomes ....................................................................... 72 4.3. Estimates of the costs to the NHS of pregnancy complications ................................................. 75 4.4. Contextualisation of pregnancy research funding, health needs and health spend ..................... 77 5. Task C results: Prioritisation exercise .......................................................................................... 82 5.1. Generating a shortlist of potential research priorities ................................................................ 82 5.2. Prioritisation survey ................................................................................................................. 82 References ............................................................................................................................................ 113 Annex A. Research tools and information forms ........................................................................... 123 A.1. List of funders approached to request the provision of funding data ..................................... 123 iv A.2. Workshop with women and their partners............................................................................ 125 A.3. Prioritisation survey: Questionnaire ...................................................................................... 129 Annex B. Data tables ..................................................................................................................... 150 B.1. Longlist of potential research topics for prioritisation ........................................................... 150 B.2. Results of survey ................................................................................................................... 223 v Figures Figure 1: Overview of study approach ...................................................................................................... 3 Figure 2: Overview of included awards from public and charitable funders ............................................ 34 Figure 3: Number of awards by year, core analysis. ................................................................................. 35 Figure 4: Funding value by year, core analysis. ....................................................................................... 36 Figure 5: Number of awards by host institution sector, core analysis. ..................................................... 36 Figure 6: Funding value by host institution sector, core analysis. ............................................................ 36 Figure 7: Number of awards by funder sector, core analysis. ................................................................... 37 Figure 8: Funding value by funder sector, core analysis. ......................................................................... 37 Figure 9: Number of awards by award type, core analysis. ...................................................................... 38 Figure 10: Funding value by award type, core analysis. ........................................................................... 38 Figure 11: Number of awards by research type, core analysis. ................................................................. 39 Figure 12: Funding value by research type, core analysis. ........................................................................ 39 Figure 13: Number of awards by stage of pregnancy, core analysis. ......................................................... 40 Figure 14: Funding value by stage of pregnancy, core analysis. ............................................................... 40 Figure 15: Number of awards by topic, core analysis. ............................................................................. 41 Figure 16: Funding value by topic, core analysis. .................................................................................... 41 Figure 17: Number of awards by topic within the category ‘Context’, core analysis. ............................... 42 Figure 18: Funding value by topic within the category ‘Context’, core analysis. ...................................... 42 Figure 19: Number of awards by subtopic within the category ‘Context’ for subtopics with at least 5 awards, core analysis. .............................................................................................................................. 43 Figure 20: Funding value by subtopic within the category ‘Context’ for subtopics receiving at least £2m in funding, core analysis.
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