Supplemental Table 1: Snps Genotyped for NCO, Listed Alphabetically by Gene Name

Supplemental Table 1: SNPs genotyped for NCO, listed alphabetically by gene name. Gene Name SNP rs# ACVR1 rs10497189 ACVR1 rs10497191 ACVR1 rs10497192 ACVR1 rs10933441 ACVR1 rs1146035 ACVR1 rs1220110 ACVR1 rs17182166 ACVR1 rs17798043 ACVR1 rs4380178 ACVR1 rs6719924 ACVR2 rs1128919 ACVR2 rs10497025 ACVR2 rs1424941 ACVR2 rs1424954 ACVR2 rs17742573 ACVR2 rs2382112 ACVR2 rs4419186 AKT2 rs11671439 AKT2 rs12460555 AKT2 rs16974157 AKT2 rs2304188 AKT2 rs3730050 AKT2 rs7250897 AKT2 rs7254617 AKT2 rs874269 ALOX12B/ALOXE3 rs3809881 ALOX15B rs4792147 ALOX15B rs9898751 AMH rs10407022 AMH rs2074860 AMH rs3746158 AMH rs4806834 AMH rs757595 AMH rs886363 AMHR2 rs10876451 AMHR2 rs11170547 AMHR2 rs11170558 APC rs2229992 APC rs351771 APC rs41115 APC rs42427 APC rs459552 APC rs465899 APEX1 rs2275007 APEX1 rs3136820

15 APEX1 rs938883 APEX1 rs11160711 APEX1 rs1713459 APEX1 rs1713460 APEX1 rs1760941 APEX1 rs2275008 APEX1 rs3120073 APEX1 rs4465523 AR rs12011793 AR rs1204038 AR rs1337080 AR rs1337082 AR rs2207040 AR rs2361634 AR rs5031002 AR rs6152 AR rs962458 ATM rs1800058 ATM rs1800889 ATM rs11212570 ATM rs17503908 ATM rs227060 ATM rs228606 ATM rs3092991 ATM rs4987876 ATM rs4987886 ATM rs4987923 ATM rs4988023 ATM rs611646 ATM rs639923 ATM rs672655 ATR rs2229032 ATR rs10804682 ATR rs11920625 ATR rs13065800 ATR rs13085998 ATR rs13091637 ATR rs1802904 ATR rs6805118 ATR rs9856772 BACH1 rs388707 BACH1 rs1153276 BACH1 rs1153280 BACH1 rs1153284 BACH1 rs1153285 BACH1 rs17743655 BACH1 rs17744121 BACH1 rs2300301 BACH1 rs2832283

16 BACH1 rs411697 BACH1 rs425989 BARD1 rs1048108 BARD1 rs2070096 BARD1 rs2229571 BARD1 rs10498020 BARD1 rs10932568 BARD1 rs12474696 BARD1 rs12477063 BARD1 rs12614960 BARD1 rs13423596 BARD1 rs16852689 BARD1 rs16852755 BARD1 rs1979028 BARD1 rs2166459 BARD1 rs2372334 BARD1 rs280621 BARD1 rs3754546 BARD1 rs3768704 BARD1 rs3768707 BARD1 rs3820727 BARD1 rs4234006 BARD1 rs4672729 BARD1 rs5031011 BARD1 rs6413460 BARD1 rs6435862 BARD1 rs6751923 BARD1 rs6757091 BARD1 rs7584646 BARD1 rs7591615 BRAF rs11771946 BRAF rs1267622 BRAF rs1267635 BRAF rs13446911 BRAF rs17161747 BRAF rs17623382 BRAF rs1922283 BRAF rs2930322 BRAF rs3829814 BRAF rs6464984 BRAF rs6944385 BRAF rs9648716 BRCA1 rs1060915 BRCA1 rs16940 BRCA1 rs16941 BRCA1 rs16942 BRCA1 rs1799966 BRCA1 rs4986850 BRCA1 rs799917

17 BRCA1 rs3737559 BRCA1 rs799923 BRCA1 rs8176199 BRCA1 rs8176256 BRCA2 rs144848 BRCA2 rs1801406 BRCA2 rs543304 BRCA2 rs10492397 BRCA2 rs1148321 BRCA2 rs11571686 BRCA2 rs11571789 BRCA2 rs11571805 BRCA2 rs1207952 BRCA2 rs17692629 BRCA2 rs1799943 BRCA2 rs206079 BRCA2 rs206081 BRCA2 rs206109 BRCA2 rs206110 BRCA2 rs206111 BRCA2 rs206119 BRCA2 rs206146 BRCA2 rs2126042 BRCA2 rs2761367 BRCA2 rs3092989 BRCA2 rs3752447 BRCA2 rs3752451 BRCA2 rs3764792 BRCA2 rs9534154 BRCA2 rs9534262 BRCA2 rs9567552 BRCA2 rs9943888 BRIP1 rs4986763 BRIP1 rs4986764 BRIP1 rs4986765 BRIP1 rs11652980 BRIP1 rs11654606 BRIP1 rs12452396 BRIP1 rs16945628 BRIP1 rs16945643 BRIP1 rs2024188 BRIP1 rs2048718 BRIP1 rs2159451 BRIP1 rs2191248 BRIP1 rs4968451 BRIP1 rs4988343 BRIP1 rs4988344 BRIP1 rs7212340 BRIP1 rs7213430

18 BRIP1 rs7223243 BRIP1 rs9908659 CCND1 rs603965 CCND1 rs11603541 CCND1 rs2450254 CCND1 rs649392 CCND1 rs667515 CCND1 rs7178 CCNE1 rs1406 CCNE1 rs1862541 CCNE1 rs4804903 CCNE1 rs7257330 CCNE1 rs8100652 CCNE1 rs8102137 CCNE1 rs997669 CDKN1A rs1801270 CDKN1A rs1977172 CDKN1A rs12176359 CDKN1A rs12207548 CDKN1A rs2145047 CDKN1A rs2395656 CDKN1A rs3829963 CDKN1A rs6457938 CDKN1A rs6457940 CDKN1A rs733590 CDKN1A rs7767246 CDKN1B rs2066827 CDKN1B rs10845613 CDKN1B rs10845619 CDKN1B rs1420023 CDKN1B rs2417223 CDKN1B rs3093736 CDKN1B rs34322 CDKN1B rs34329 CDKN1B rs34330 CDKN1B rs3759216 CDKN1B rs3759217 CDKN1C rs10488671 CDKN1C rs10766441 CDKN1C rs10832869 CDKN1C rs12786533 CDKN1C rs16924912 CDKN1C rs16928791 CDKN1C rs2078786 CDKN1C rs2283230 CDKN1C rs2283231 CDKN1C rs384037 CDKN1C rs3864883 CDKN1C rs400643

19 CDKN1C rs452338 CDKN1C rs4930026 CDKN2A rs1063192 CDKN2A rs2518719 CDKN2A rs2811708 CDKN2A rs2811709 CDKN2A rs3218009 CDKN2A rs3218020 CDKN2A rs3731239 CDKN2A rs7041637 CDKN2A rs717326 CHEK1 rs17140116 CHEK1 rs506504 CHEK1 rs10893405 CHEK1 rs11820487 CHEK1 rs2298483 CHEK1 rs3731399 CHEK1 rs3731426 CHEK1 rs3731438 CHEK1 rs485231 CHEK1 rs491741 CHEK1 rs525186 CHEK1 rs537046 CHEK1 rs540723 CHEK1 rs565416 CHEK2 rs1076807 CHEK2 rs17508019 CHEK2 rs1884817 CHEK2 rs2073327 CHEK2 rs2236141 CHEK2 rs2236142 CHEK2 rs5752773 CHEK2 rs5752785 CHEK2 rs5762746 CHEK2 rs5762763 CHEK2 rs6005834 CHEK2 rs6005835 CHEK2 rs9608698 CHEK2 rs9613664 CHEK2 rs9625534 CHL1 rs2272522 COMT rs165815 COMT rs4680 CTNNB1 rs11564445 CTNNB1 rs4135385 CTNNB1 rs4533622 CTNNB1 rs9311265 CYP17A1 rs6162 CYP17A1 rs1004467

20 CYP17A1 rs10883782 CYP17A1 rs10883783 CYP17A1 rs17724534 CYP17A1 rs2486758 CYP17A1 rs3824755 CYP17A1 rs619824 CYP19A1 rs700518 CYP27B1 rs8176345 CYP2C8 rs10509681 CYP2C9 rs1057910 CYP2C9 rs1057911 CYP2E1 rs2515641 CYP3A4 rs12333983 CYP3A4 rs2242480 CYP3A4 rs4646437 CYP3A5 rs10242455 CYP3A5 rs4646450 CYP3A7 rs2257401 CYSLTR1 rs320995 DDB2 rs10742797 DDB2 rs11039130 DDB2 rs11988 DDB2 rs1685404 DDB2 rs2029298 DDB2 rs2291120 DDB2 rs2306353 DDB2 rs2957873 DDB2 rs326222 DDB2 rs3781619 DDB2 rs4567413 DDB2 rs4647709 DDB2 rs4752973 DDB2 rs901746 DHFR rs10072026 DHFR rs11951910 DHFR rs12189317 DHFR rs1232027 DHFR rs12517451 DHFR rs1650723 DHFR rs1677693 DHFR rs380691 DHFR rs836823 DHFR rs844370 DNMT1 rs2228611 DNMT1 rs2241531 DNMT1 rs759920 DNMT1 rs9305012 DNMT2 rs11254408 DNMT2 rs11254413

21 DNMT2 rs2273734 DNMT2 rs7096233 DNMT2 rs10904907 DNMT2 rs12770606 DNMT2 rs17465759 DNMT2 rs4748362 DNMT2 rs6602180 DNMT2 rs7084637 DNMT2 rs7096692 DNMT3A rs10196635 DNMT3A rs11677670 DNMT3A rs11683424 DNMT3A rs11694842 DNMT3A rs11695471 DNMT3A rs11887120 DNMT3A rs11892646 DNMT3A rs12987326 DNMT3A rs12991495 DNMT3A rs13036246 DNMT3A rs13428812 DNMT3A rs1465764 DNMT3A rs2289195 DNMT3A rs2304429 DNMT3A rs4665783 DNMT3A rs6546045 DNMT3A rs6739187 DNMT3A rs6749992 DNMT3A rs734693 DNMT3A rs749131 DNMT3A rs7560488 DNMT3A rs7575625 DNMT3A rs7578575 DNMT3A rs7581217 DNMT3A rs7583409 DNMT3A rs7587636 DNMT3B rs2424922 DNMT3B rs6058891 DNMT3B rs2424905 DNMT3B rs2424908 DNMT3B rs2424932 DNMT3B rs437302 DNMT3B rs4911263 DNMT3B rs6058894 DNMT3B rs6058896 DNMT3B rs6058897 DNMT3B rs6141803 DNMT3B rs709046 DNMT3B rs853858 DNMT3B rs998382

22 DNMT3L rs7354779 DNMT3L rs2014457 DNMT3L rs2026880 DNMT3L rs2070561 DNMT3L rs2070562 DNMT3L rs2155724 DNMT3L rs2838540 DNMT3L rs3737435 DNMT3L rs378299 DNMT3L rs3788111 DNMT3L rs762424 DNMT3L rs968447 E2F1 rs3213182 E2F1 rs3213183 EGF rs11568943 EGF rs11568993 EGF rs11569017 EGF rs2237051 EGF rs4698803 EGFR rs10251977 EGFR rs1140475 EGFR rs11543848 EGFR rs2072454 EGFR rs2293347 EP300 rs1046088 EP300 rs20551 EPHX1 rs1009668 EPHX1 rs1051740 EPHX1 rs1051741 EPHX1 rs10753410 EPHX1 rs10915884 EPHX1 rs1877724 EPHX1 rs2260863 EPHX1 rs2740168 EPHX1 rs2740170 EPHX1 rs2854450 EPHX1 rs360063 EPHX1 rs3753658 EPHX1 rs868966 ERBB2 rs1058808 ERBB2 rs1801200 ERBB2 rs1565923 ERBB2 rs1810132 ERBB2 rs2952155 ERBB2 rs4252665 ERBB2 rs9896218 ERCC1 rs11615 ERCC1 rs2336219 ERCC1 rs3212986

23 ERCC1 rs735482 ERCC1 rs2298881 ERCC1 rs3212948 ERCC1 rs3212955 ERCC1 rs3212964 ERCC1 rs4803817 ERCC2 rs13181 ERCC2 rs238406 ERCC2 rs10853773 ERCC2 rs11878644 ERCC2 rs1618536 ERCC2 rs171140 ERCC2 rs1799787 ERCC2 rs238415 ERCC2 rs3916874 ERCC2 rs50871 ERCC2 rs50872 ERCC2 rs6966 ERCC3 rs1566823 ERCC3 rs1803541 ERCC3 rs3738948 ERCC3 rs4150403 ERCC3 rs4150471 ERCC4 rs1799801 ERCC4 rs1800067 ERCC4 rs12597883 ERCC4 rs12924220 ERCC4 rs2276465 ERCC4 rs3136166 ERCC4 rs4781560 ERCC5 rs1047768 ERCC5 rs17655 ERCC5 rs2227869 ERCC5 rs1886087 ERCC5 rs2016073 ERCC5 rs2296147 ERCC5 rs4150276 ERCC5 rs4150351 ERCC5 rs4150355 ERCC5 rs4150383 ERCC5 rs4150386 ERCC5 rs4150393 ERCC5 rs4743 ERCC5 rs7325708 ERCC5 rs7334764 ERCC5 rs876430 ERCC6 rs2228526 ERCC6 rs2228528 ERCC6 rs2228529

24 ERCC6 rs2229760 ERCC6 rs4253073 ERCC6 rs4253211 ERCC6 rs1012554 ERCC6 rs1018603 ERCC6 rs12217474 ERCC6 rs3750751 ERCC6 rs3793784 ERCC6 rs3810945 ERCC6 rs4253200 ERCC6 rs6537539 ERCC6 rs7907557 ESR1 rs1801132 ESR1 rs1062577 ESR1 rs12199102 ESR1 rs1543403 ESR1 rs1709183 ESR1 rs1884051 ESR1 rs1884052 ESR1 rs2077647 ESR1 rs2813544 ESR1 rs2881766 ESR1 rs2982683 ESR1 rs2982896 ESR1 rs2982900 ESR1 rs3003925 ESR1 rs3020314 ESR1 rs3020317 ESR1 rs3020318 ESR1 rs3020366 ESR1 rs3020383 ESR1 rs3020407 ESR1 rs3020411 ESR1 rs3778099 ESR1 rs488133 ESR1 rs532010 ESR1 rs6905370 ESR1 rs6927072 ESR1 rs712221 ESR1 rs750686 ESR1 rs7757956 ESR1 rs7761133 ESR1 rs7761846 ESR1 rs827420 ESR1 rs827421 ESR1 rs851984 ESR1 rs910416 ESR1 rs926778 ESR1 rs9322336

25 ESR1 rs9340835 ESR1 rs9340954 ESR1 rs985694 ESR1 rs988328 ESR2 rs1109056 ESR2 rs1152579 ESR2 rs12434245 ESR2 rs12435284 ESR2 rs12435857 ESR2 rs1255998 ESR2 rs1256061 ESR2 rs1256063 ESR2 rs1271572 ESR2 rs17179740 ESR2 rs1887994 ESR2 rs1952586 ESR2 rs2978381 ESR2 rs3020450 ESR2 rs4365213 ESR2 rs4986938 ESR2 rs7157428 ESR2 rs7159462 ESR2 rs8003490 ESR2 rs8006145 ESR2 rs8017441 ESR2 rs8020646 ESR2 rs928554 ESRRA rs2276014 ESRRA rs11231745 ESRRA rs11600990 ESRRA rs4930702 ESRRA rs731703 ESRRA rs9787810 EXO1 rs1047840 EXO1 rs1776148 EXO1 rs4149963 EXO1 rs735943 EXO1 rs10802995 EXO1 rs10802996 EXO1 rs11581448 EXO1 rs12118937 EXO1 rs17391703 EXO1 rs1776139 EXO1 rs1776177 EXO1 rs1776179 EXO1 rs2073490 EXO1 rs2797604 EXO1 rs3754093 EXO1 rs4149867

26 EXO1 rs4149982 EXO1 rs4150018 EXO1 rs4408133 EXO1 rs4658535 EXO1 rs7521516 EXO1 rs851777 F13A rs5985 F13A rs5987 F2 rs5896 F2 rs5898 F5 rs4524 F5 rs6015 F5 rs6018 F5 rs6019 F5 rs6022 F5 rs6025 F5 rs6027 F5 rs6028 F5 rs6029 F5 rs6030 F5 rs6032 F5 rs6035 F5 rs6036 F5 rs6128 F5 rs6133 F5 rs6136 FANCA rs2239359 FANCA rs7190823 FANCA rs7195066 FANCA rs1006548 FANCA rs11649196 FANCA rs12446555 FANCA rs12709092 FANCA rs12924101 FANCA rs13339414 FANCA rs16966142 FANCA rs17684004 FANCA rs1800286 FANCA rs1800339 FANCA rs2238526 FANCA rs3803689 FANCA rs4785594 FANCA rs7185737 FANCA rs7187436 FANCA rs7189734 FANCA rs7204478 FANCA rs8046872 FANCA rs8058895 FANCC rs12380720

27 FANCC rs1326188 FANCC rs13292454 FANCC rs16912035 FANCC rs1699499 FANCC rs356665 FANCC rs356669 FANCC rs3780560 FANCC rs4647519 FANCC rs4647558 FANCC rs4744443 FANCC rs646350 FANCC rs944934 FANCD2 rs1053239 FANCD2 rs3172417 FANCD2 rs803335 FANCD2 rs8411 FANCD2 rs9813284 FANCE rs11962335 FANCE rs2076173 FANCE rs2395626 FANCE rs7757405 FANCF rs12805507 FANCF rs3740615 FANCF rs4447177 FANCF rs448101 FANCF rs7109087 FANCG rs2299612 FANCG rs587118 FANCG rs637885 FSHB rs6169 FSHB rs12577729 FSHB rs1716022 FSHB rs1782507 FSHB rs621686 FSHB rs7951733 FSHR rs6165 FSHR rs6166 FUCA1 rs13551 FUCA1 rs11803575 FUCA1 rs12744386 GADD45A rs10889710 GADD45A rs11583718 GADD45A rs12408005 GADD45A rs1706079 GADD45A rs2815266 GADD45A rs344915 GADD45A rs344916 GADD45A rs511041 GADD45A rs520820

28 GADD45A rs681673 GADD45A rs7414246 GADD45A rs7546055 GADD45B rs10420027 GADD45B rs11670333 GADD45B rs13345846 GADD45B rs1548708 GADD45B rs16991159 GADD45B rs3783501 GADD45B rs3783508 GADD45B rs4806857 GADD45B rs7249224 GADD45B rs8109281 GADD45B rs929461 GADD45G rs10120108 GADD45G rs10908902 GADD45G rs1475537 GADD45G rs2031971 GADD45G rs3138513 GADD45G rs3763668 GADD45G rs4877109 GADD45G rs7873096 GADD45G rs870151 GADD45G rs870926 GHR rs6179 GHR rs6180 GNRH1 rs2709618 GNRH1 rs6185 GNRH2 rs6051545 GNRHR rs4986942 HDAC1 rs1741981 HDAC2 rs10499079 HDAC2 rs11391 HDAC2 rs12208304 HDAC2 rs17792118 HDAC2 rs352063 HDAC2 rs352068 HDAC2 rs3757016 HDAC2 rs3778216 HDAC2 rs538681 HDAC2 rs6568819 HDAC2 rs6908846 HDAC2 rs7748936 HDAC2 rs9481408 HDAC2 rs9488289 HELLS rs11188019 HELLS rs10882476 HELLS rs12248434 HELLS rs12774901

29 HELLS rs17519764 HELLS rs1969815 HELLS rs1977288 HELLS rs2025445 HRAS rs11246169 HRAS rs12577324 HRAS rs2894649 HRAS rs4963176 ICAM1 rs1056538 ICAM1 rs1799969 ICAM1 rs2228615 ICAM1 rs5498 ICAM1 rs281432 ICAM1 rs281438 ICAM1 rs281439 ICAM1 rs281440 ICAM1 rs3093030 ICAM1 rs3093032 ICAM1 rs5030390 ICAM1 rs885743 IGF1 rs1019731 IGF1 rs10778176 IGF1 rs10860860 IGF1 rs10860861 IGF1 rs10860862 IGF1 rs11111272 IGF1 rs11831436 IGF1 rs12821878 IGF1 rs1520220 IGF1 rs17727841 IGF1 rs2033178 IGF1 rs2195240 IGF1 rs2946834 IGF1 rs35765 IGF1 rs35767 IGF1 rs5009837 IGF1 rs5742620 IGF1 rs5742632 IGF1 rs6214 IGF1 rs6219 IGF1 rs7136446 IGF1 rs7956547 IGF1 rs9989002 IGF1R rs2229765 IGF1R rs3743262 IGF2 rs1003483 IGF2 rs2585 IGF2 rs3213221 IGF2 rs3802971

30 IGF2 rs4244808 IGF2 rs734351 IGF2R rs1570070 IGF2R rs1803989 IGF2R rs8191754 IGF2R rs894817 IGF2R rs998075 IGFBP1 rs4619 IGFBP1 rs4988515 IGFBP1 rs10231774 IGFBP1 rs13441765 IGFBP1 rs1496497 IGFBP1 rs3763497 IGFBP1 rs6964374 IGFBP1 rs6966060 IGFBP1 rs7454 IGFBP1 rs9658239 IGFBP2 rs1525608 IGFBP2 rs2067041 IGFBP2 rs2241199 IGFBP2 rs2270360 IGFBP2 rs2372848 IGFBP2 rs3276 IGFBP2 rs3770473 IGFBP2 rs4674104 IGFBP2 rs4674107 IGFBP2 rs9341130 IGFBP2 rs9341145 IGFBP2 rs9341156 IGFBP2 rs9341191 IGFBP2 rs9341218 IGFBP3 rs12671484 IGFBP3 rs12702181 IGFBP3 rs13223993 IGFBP3 rs2270628 IGFBP3 rs2453836 IGFBP3 rs2453839 IGFBP3 rs2453840 IGFBP3 rs3110697 IGFBP3 rs6670 IGFBP3 rs903889 IGFBP3 rs924140 IL10 rs10494879 IL10 rs11119474 IL10 rs17015767 IL10 rs1800872 IL10 rs1800890 IL10 rs1800894 IL10 rs1800896

31 IL10 rs3021094 IL10 rs3024505 IL10 rs4390174 IL10 rs6673928 IL10 rs6686931 IL10 rs7548373 IL18 rs360712 IL18 rs549908 IL18 rs11214108 IL18 rs1293344 IL18 rs1834481 IL18 rs1946519 IL18 rs2043055 IL18 rs243908 IL18 rs4937113 IL18 rs5744247 IL18 rs5744258 IL18 rs5744280 IL1R1 rs2228139 IL6 rs10242595 IL6 rs10499563 IL6 rs11766273 IL6 rs12700386 IL6 rs1474348 IL6 rs2056576 IL6 rs2069833 IL6 rs2069840 IL6 rs2069861 IL6 rs7801617 IL6 rs7805828 INHA rs1039898 INHA rs2059693 INHA rs6729914 INHA rs7588807 INHA rs907141 INHBA rs10486719 INHBA rs1122291 INHBA rs11770488 INHBA rs12701929 INHBA rs2007475 INHBA rs2237432 INHBA rs2877098 INHBA rs3801158 INHBA rs7808613 INHBA rs998190 INHBB rs11902591 INHBB rs1548039 INHBB rs745723 INHBB rs7576183

32 INHBB rs7578624 INHBB rs7579169 INHBB rs7581178 INHBB rs7589138 INHBC rs2242578 INHBC rs3741414 INHBC rs3809114 INHBC rs507562 INHBC rs543410 INHBC rs7964492 INS rs6356 INS rs2070762 INS rs3842748 INS rs4320932 INS rs7924316 INSR rs2229429 INSR rs2962 INSR rs891087 KLK10 rs1048328 KLK10 rs10426 KLK10 rs1048344 KLK10 rs11672663 KLK10 rs1474520 KLK10 rs2250066 KLK10 rs2569443 KLK10 rs2569448 KLK10 rs2569478 KLK10 rs2691257 KLK10 rs2739430 KLK10 rs6509510 KLK10 rs952109 LHCGR rs10495960 LHCGR rs11125179 LHCGR rs2293275 LIG1 rs20580 LIG1 rs10405655 LIG1 rs156640 LIG1 rs156645 LIG1 rs2241721 LIG1 rs2304136 LIG1 rs2386523 LIG1 rs251692 LIG1 rs274860 LIG1 rs274873 LIG1 rs274883 LIG1 rs3730913 LIG1 rs3730994 LIG1 rs3731007 LIG1 rs3731014

33 LIG1 rs3786764 LIG1 rs754948 LIG3 rs1003918 LIG3 rs2066505 LIG3 rs2074516 LIG3 rs3135962 LIG3 rs3135967 LIG3 rs3135989 LIG3 rs3135998 LIG3 rs3744358 LIG3 rs4796030 LIG4 rs1805386 LIG4 rs1805388 LIG4 rs10131 LIG4 rs1105451 LIG4 rs1151403 LIG4 rs1555902 LIG4 rs17497319 LIG4 rs3093748 LIG4 rs3093772 LIG4 rs7322498 LIG4 rs868284 LIG4 rs915047 LIG4 rs9514825 LIG4 rs9520820 LIG4 rs9520823 LIG4 rs9587525 LTB4R rs2144494 MAL rs1316873 MAL rs2279785 MAL rs3113002 MAL rs6747563 MAL rs7560571 MAL rs7565772 MBL2 rs1800450 MBL2 rs930507 MBL2 rs11003125 MBL2 rs7096206 MDM2 rs769412 MDM2 rs1144943 MDM2 rs1470383 MDM2 rs1625525 MDM2 rs1695144 MDM2 rs3730536 MDM2 rs3730581 MLH1 rs1799977 MLH1 rs10440109 MLH1 rs13320360 MLH1 rs3774332

34 MLH1 rs3774341 MLH1 rs749072 MLH1 rs9311149 MLH1 rs9852810 MLH3 rs13712 MLH3 rs175057 MLH3 rs175512 MLH3 rs3742780 MRE11 rs10831225 MRE11 rs11020773 MRE11 rs12224897 MRE11 rs13447623 MRE11 rs13447720 MRE11 rs16920467 MRE11 rs2508678 MRE11 rs500558 MRE11 rs592068 MRE11 rs610611 MRE11 rs654718 MRE11 rs663530 MSH2 rs10495944 MSH2 rs10514805 MSH2 rs12998837 MSH2 rs13408008 MSH2 rs13425206 MSH2 rs17036577 MSH2 rs1863332 MSH2 rs1981929 MSH2 rs2303428 MSH2 rs3771281 MSH2 rs4638843 MSH2 rs4952887 MSH2 rs6544991 MSH2 rs6726691 MSH2 rs6741393 MSH3 rs10041898 MSH3 rs11950902 MSH3 rs12513549 MSH3 rs12515548 MSH3 rs13168327 MSH3 rs151886 MSH3 rs1650649 MSH3 rs1650737 MSH3 rs1677652 MSH3 rs16878166 MSH3 rs17206221 MSH3 rs181747 MSH3 rs2086188 MSH3 rs2306371

35 MSH3 rs245343 MSH3 rs245346 MSH3 rs245359 MSH3 rs249633 MSH3 rs249634 MSH3 rs26266 MSH3 rs26784 MSH3 rs27385 MSH3 rs28059 MSH3 rs32989 MSH3 rs33003 MSH3 rs33013 MSH3 rs3797896 MSH3 rs397628 MSH3 rs4703819 MSH3 rs6151616 MSH3 rs6151630 MSH3 rs6151639 MSH3 rs6151640 MSH3 rs6151662 MSH3 rs6151735 MSH3 rs6151792 MSH3 rs6151912 MSH3 rs863221 MSH3 rs865644 MSH4 rs5745325 MSH4 rs1146644 MSH4 rs12164500 MSH4 rs12409592 MSH4 rs1251272 MSH4 rs1498311 MSH4 rs1498313 MSH4 rs5745314 MSH4 rs5745513 MSH4 rs6683437 MSH4 rs721204 MSH6 rs1800932 MSH6 rs1800935 MSH6 rs1800937 MSH6 rs10490302 MSH6 rs10490303 MSH6 rs17323768 MSH6 rs1800936 MSH6 rs2348244 MSH6 rs2710163 MSH6 rs3136245 MSH6 rs3136326 MSH6 rs3136329 MSH6 rs3136337

36 MSH6 rs3136367 MSH6 rs330787 MSH6 rs330792 MSH6 rs3732191 MSH6 rs6713506 MTHFR rs1801131 MTHFR rs1801133 MTHFR rs2066462 MTHFR rs2274976 MTHFR rs7538516 MTHFR rs11121832 MTHFR rs12121543 MTHFR rs12134663 MTHFR rs13306567 MTHFR rs1476413 MTHFR rs1572151 MTHFR rs17367504 MTHFR rs17375901 MTHFR rs17421462 MTHFR rs17421511 MTHFR rs3753582 MTHFR rs4846048 MTHFR rs4846049 MTHFR rs6687229 MTHFR rs6697244 MTHFR rs9651118 MUC1 rs3814316 MUC1 rs4072037 MUC16 rs1035442 MUC16 rs10854117 MUC16 rs11672574 MUC16 rs11673197 MUC16 rs11882373 MUC16 rs12460359 MUC16 rs12462672 MUC16 rs12975129 MUC16 rs12985992 MUC16 rs1862456 MUC16 rs2059136 MUC16 rs2967741 MUC16 rs3764552 MUC16 rs3764553 MUC16 rs873869 MUC16 rs881877 MUC16 rs9749347 NBS1 rs1061302 NBS1 rs1063045 NBS1 rs1805794 NBS1 rs709816

37 NBS1 rs1063053 NBS1 rs1235369 NBS1 rs12680687 NBS1 rs16893166 NBS1 rs1805810 NBS1 rs1805811 NBS1 rs1805812 NBS1 rs3026271 NBS1 rs6470522 NCOA1 rs11125744 NCOA1 rs11125763 NCOA1 rs3731628 NCOA3 rs2076546 NCOA3 rs2230782 NCOR1 rs1073094 NCOR1 rs1075901 NCOR1 rs11657857 NCOR1 rs16959536 NCOR1 rs178830 NCOR1 rs9903464 NOS2A rs1137933 NOS2A rs12450521 NOS2A rs2297518 NOS2A rs7406657 NOS2A rs8081248 NRIP1 rs2229741 NRIP1 rs2229742 NRIP1 rs10482863 NRIP1 rs1056947 NRIP1 rs11088231 NRIP1 rs1297213 NRIP1 rs13050325 NRIP1 rs17241025 NRIP1 rs2249465 NRIP1 rs2822986 NRIP1 rs3787576 NRIP1 rs4816445 PARP1 rs1136410 PARP1 rs1805415 PARP1 rs12568297 PARP1 rs1805401 PARP1 rs1805410 PARP1 rs2282400 PARP1 rs3219095 PARP1 rs3219110 PARP1 rs3219142 PARP1 rs3754376 PARP1 rs6426551 PARP1 rs8679

38 PARP2 rs3093921 PARP2 rs3093930 PARP2 rs10143407 PARP2 rs11627273 PARP2 rs1713413 PARP2 rs1713419 PARP2 rs1760920 PARP2 rs1760921 PARP2 rs2297616 PARP2 rs2678681 PARP2 rs3093872 PARP2 rs3093933 PARP2 rs7160770 PARP2 rs878156 PGR rs1042838 PGR rs1042839 PGR rs500760 PGR rs1046982 PGR rs11224575 PGR rs11224579 PGR rs11224580 PGR rs11571271 PGR rs1456765 PGR rs1824128 PGR rs471767 PGR rs4754732 PGR rs481883 PGR rs492457 PGR rs495997 PGR rs507141 PGR rs508533 PGR rs508653 PGR rs518162 PGR rs537681 PGR rs542384 PGR rs555653 PGR rs563656 PGR rs578938 PGR rs590688 PGR rs601040 PGR rs619487 PGR rs635984 PGR rs653752 PGR rs660541 PGR rs694070 PGR rs936269 PGR rs948516 PIK3CA rs13082485 PIK3CA rs13320527

39 PIK3CA rs1607237 PIK3CA rs3729692 PIK3CA rs7623154 PIK3CA rs9866361 PMS1 rs1233258 PMS1 rs1233276 PMS1 rs13029721 PMS1 rs17806132 PMS1 rs256554 PMS1 rs256567 PMS1 rs4920660 PMS1 rs5743047 PMS1 rs5743185 PMS1 rs6736360 PMS2 rs6463524 PMS2 rs11769380 PMS2 rs12112229 PMS2 rs1860459 PMS2 rs2345060 PMS2 rs3779107 PMS2 rs6979676 PPARD rs2076167 PPARG rs1801282 PPARG rs3856806 PRDM2 rs1046331 PRDM2 rs1203651 PTEN rs11202596 PTEN rs1234218 PTEN rs1234219 PTEN rs1234220 PTEN rs1234221 PTEN rs12357281 PTEN rs12572106 PTEN rs17106896 PTEN rs1903858 PTEN rs2299939 PTEN rs2673832 PTEN rs478839 PTGDR rs17125273 PTGER1 rs1042728 PTGER1 rs10846 PTGER1 rs2230538 PTGER1 rs4926219 PTGER3 rs1409986 PTGER3 rs5702 PTGES2 rs13283456 PTGIS rs5628 PTGS1 rs1236913 PTGS1 rs5788

40 PTGS1 rs5789 PTGS1 rs10306135 PTGS1 rs10306202 PTGS1 rs10513402 PTGS1 rs1213266 PTGS1 rs12353214 PTGS1 rs2282169 PTGS1 rs4837960 PTGS1 rs4837963 PTGS1 rs6478565 PTGS1 rs913937 PTGS1 rs950104 PTGS2 rs5272 PTGS2 rs5273 PTGS2 rs10911902 PTGS2 rs10911905 PTGS2 rs12042763 PTGS2 rs20417 PTGS2 rs2206593 PTGS2 rs2745557 PTGS2 rs2745559 PTGS2 rs4648261 PTGS2 rs689466 RAD50 rs17772565 RAD50 rs17772583 RAD50 rs2237060 RAD50 rs2244012 RAD50 rs2706338 RAD51 rs11070292 RAD51 rs11855560 RAD51 rs1801320 RAD51 rs2304579 RAD51 rs2304580 RAD51 rs2304583 RAD51 rs3092981 RAD51 rs5030783 RAD52 rs1051669 RAD52 rs1060499 RAD52 rs10744729 RAD52 rs10849582 RAD52 rs10849605 RAD52 rs11064598 RAD52 rs11064607 RAD52 rs11064613 RAD52 rs11571424 RAD52 rs11571435 RAD52 rs11571461 RAD52 rs12822733 RAD52 rs2277869

41 RAD52 rs2286026 RAD52 rs2286028 RAD52 rs2286029 RAD52 rs3748522 RAD52 rs4766377 RAD52 rs6413436 RAD52 rs7294431 RAD52 rs7300039 RAD52 rs7307680 RAD52 rs7311151 RAD52 rs7311263 RAP80 rs13360277 RAP80 rs1700490 RAP80 rs365132 RAP80 rs3733876 RAP80 rs10516138 RAP80 rs1472920 RAP80 rs2940531 RAP80 rs2962842 RAP80 rs3762971 RAP80 rs3762974 RAP80 rs4976666 RAP80 rs6881002 RAP80 rs9313744 SHBG rs13894 SHBG rs6259 SMAD3 rs1065080 SMAD3 rs12900401 SRA1 rs250430 SRA1 rs250431 SRA1 rs10463297 SRA1 rs1835959 SRA1 rs250425 SRA1 rs250429 SRA1 rs801459 SRA1 rs801460 SRA1 rs9324644 SRD5A1 rs3822430 SRD5A1 rs10037161 SRD5A1 rs13166363 SRD5A1 rs1560149 SRD5A1 rs1651071 SRD5A1 rs166050 SRD5A1 rs16877779 SRD5A1 rs1691053 SRD5A1 rs248799 SRD5A1 rs30434 SRD5A1 rs39847 SRD5A1 rs39848

42 SRD5A1 rs471604 SRD5A1 rs472402 SRD5A1 rs482121 SRD5A1 rs518673 SRD5A1 rs566202 SRD5A1 rs6872996 SRD5A1 rs8192139 SRD5A2 rs1475054 SRD5A2 rs1884722 SRD5A2 rs2208532 SRD5A2 rs2281546 SRD5A2 rs3754838 SRD5A2 rs4952220 SRD5A2 rs4952222 SRD5A2 rs612224 SRD5A2 rs632148 SRD5A2 rs6732223 SRD5A2 rs7562326 STK6 rs1047972 STK6 rs2273535 STK6 rs6099115 TBXA2R rs4523 TBXA2R rs8113232 TBXAS1 rs2286196 TBXAS1 rs3735352 TGFB1 rs2241714 TNF rs2857713 TNF rs2256965 TNF rs2256974 TNF rs2844482 TNF rs3093662 TNF rs3131637 TNF rs9267502 TP53 rs1042522 TP53 rs2287498 TP53 rs2287499 TP53 rs12951053 TP53 rs1625895 TP53 rs2078486 TP53 rs2287497 TP53 rs2909430 TP53 rs8073498 TP53 rs8079544 TP53I3 rs10194831 TP53I3 rs10200844 TP53I3 rs10495746 TP53I3 rs2303287 UGT1A6 rs1105880 UGT1A6 rs12475068

43 UGT1A6 rs17864686 UGT1A6 rs2011404 UGT1A6 rs2070959 UGT1A6 rs3755321 UGT1A6 rs3892170 UGT1A6 rs6431631 UGT1A6 rs6755571 UGT1A6 rs6759892 UGT1A6 rs7574296 UGT1A6 rs7577677 VDR rs10735810 VEGF rs1547651 VEGF rs3025010 VEGF rs3025022 VEGF rs3025033 VEGF rs3025035 VEGF rs6900017 VEGF rs699946 VEGF rs699947 VEGF rs833058 VEGF rs833060 VEGF rs998584 XRCC1 rs11407 XRCC1 rs1001581 XRCC1 rs2023614 XRCC1 rs2256507 XRCC1 rs2682587 XRCC1 rs2682588 XRCC1 rs2854496 XRCC1 rs2854509 XRCC1 rs2854510 XRCC1 rs3213255 XRCC1 rs3213263 XRCC1 rs3213266 XRCC1 rs3213344 XRCC1 rs3213403 XRCC1 rs939461 XRCC2 rs3218536 XRCC2 rs2040639 XRCC2 rs3218408 XRCC2 rs3218455 XRCC2 rs6464268 XRCC2 rs6464269 XRCC2 rs6964582 XRCC2 rs6970449 XRCC2 rs6975064 XRCC2 rs7384368 XRCC2 rs757052 XRCC3 rs861539

44 XRCC3 rs861544 XRCC3 rs11846404 XRCC3 rs12432907 XRCC3 rs1799794 XRCC3 rs2273175 XRCC3 rs3212079 XRCC3 rs3212102 XRCC3 rs861528 XRCC3 rs861531 XRCC3 rs861547 XRCC3 rs941474 XRCC4 rs10041617 XRCC4 rs10057194 XRCC4 rs1011980 XRCC4 rs10474078 XRCC4 rs10474079 XRCC4 rs10805813 XRCC4 rs10942325 XRCC4 rs1193693 XRCC4 rs1193695 XRCC4 rs13178127 XRCC4 rs13180316 XRCC4 rs13180356 XRCC4 rs1382367 XRCC4 rs1478480 XRCC4 rs1478483 XRCC4 rs16900340 XRCC4 rs16900343 XRCC4 rs177297 XRCC4 rs1993947 XRCC4 rs2061783 XRCC4 rs2075685 XRCC4 rs301275 XRCC4 rs301287 XRCC4 rs3777018 XRCC4 rs4703950 XRCC4 rs4703951 XRCC4 rs6452501 XRCC4 rs7711825 XRCC4 rs7720588 XRCC4 rs7735781 XRCC4 rs963248 XRCC5 rs207906 XRCC5 rs10166817 XRCC5 rs13002401 XRCC5 rs13006837 XRCC5 rs1364726 XRCC5 rs16855458 XRCC5 rs16855489

45 XRCC5 rs16855663 XRCC5 rs207887 XRCC5 rs207908 XRCC5 rs207910 XRCC5 rs207921 XRCC5 rs207936 XRCC5 rs207943 XRCC5 rs2241320 XRCC5 rs2303400 XRCC5 rs3821104 XRCC5 rs3821107 XRCC5 rs668844 XRCC5 rs7583902 XRCC5 rs828699 XRCC5 rs828704 XRCC5 rs828705 XRCC5 rs828918 XRCC6 (G22P1) rs132788 XRCC6 (G22P1) rs11703638 XRCC6 (G22P1) rs132765 XRCC6 (G22P1) rs2267437 NCO, North Carolina Ovarian Cancer Study.

46 Supplemental Table 2: Haplotype analysis of IL18 and epithelial ovarian cancer risk among Caucasian women in the North Carolina Ovarian Cancer Study. Haplotype* Haplotype Frequency Chi-Square P-value ACAAAAACAAA 0.299 3.332 0.068 CACAAACACCA 0.270 1.987 0.1587 AAACCAAAAAA 0.251 10.843 0.0010 AAAAACCACAC 0.092 0.0020 0.9684 CACAAACCAAA 0.033 1.102 0.2938 ACAAAAACCAC 0.028 0.885 0.347 AAAAAACACAA 0.015 0.0 0.9945 *Based on SNPs rs243908 (A), rs5744280 (A), rs549908 (A), rs5744258 (C), rs1834481 (C), rs5744247 (C), rs4937113 (A), rs2043055 (A), rs1946519 (A), rs1293344 (A), and rs11214108 (A) where the letter in parentheses corresponds to the associated allele for that particular SNP.