bioRxiv preprint doi: https://doi.org/10.1101/047456; this version posted April 6, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia Patricia Marreroa1, Khaled K. Abu-Amerob1, Jose M Larrugac, Vicente M. Cabrerac2* aSchool of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, Norfolk, England. bGlaucoma Research Chair, Department of ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. cDepartamento de Genética, Facultad de Biología, Universidad de La Laguna, La Laguna, Tenerife, Spain. * Corresponding author. E-mail address:
[email protected] (V.M. Cabrera) 1Both authors equally contributed 2Actually retired 1 bioRxiv preprint doi: https://doi.org/10.1101/047456; this version posted April 6, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. ABSTRACT Objetives We suggest that the phylogeny and phylogeography of mtDNA macrohaplogroup M in Eurasia and Australasia is better explained supposing an out of Africa of modern humans following a northern route across the Levant than the most prevalent southern coastal route across Arabia and India proposed by others. Methods A total 206 Saudi samples belonging to macrohaplogroup M have been analyzed. In addition, 4107 published complete or nearly complete Eurasian and Australasian mtDNA genomes ascribed to the same macrohaplogroup have been included in a global phylogeographic analysis. Results Macrohaplogroup M has only historical implantation in West Eurasia including the Arabian Peninsula.