Athlete's Foot Treating Athlete's Foot

Total Page:16

File Type:pdf, Size:1020Kb

Athlete's Foot Treating Athlete's Foot Athlete's foot Treating athlete's foot Most people can treat athlete’s foot at home. This type of fungal infection is usually mild and responds quickly to treatment. Most cases of athlete’s foot can be treated using self care and an antifungal medicine. If your infection is more severe, your GP may prescribe some stronger medication, such as oral antifungal medication. If the infection is not treated, it can sometimes spread to your toenails and other parts of your body, such as the palms of your hands. Untreated cases of athlete’s foot can also lead to complications, such as bacterial infection. See Complications of athlete’s foot. Self care The following steps can help you treat athlete’s foot: ● Wash your feet frequently and thoroughly with soap and water. ● After washing, dry your feet, paying particular attention to the areas between your toes. ● Wear clean cotton socks. ● Change your shoes and socks regularly to help keep your feet dry, particularly after exercising. ● Do not share towels and ensure that they are washed regularly. Antifungal treatment Antifungal medication will help kill the fungi causing your infection. This type of medicine is available in several different forms, including: ● creams ● sprays ● liquids ● powders ● tablets NHS Choices puts you in control of your healthcare NHS Choices has been developed to help you make choices about your health, from lifestyle decisions about things like smoking, drinking and excercise, through to the practical aspects of finding and using NHS services when you need them. www.nhs.uk Topical antifungal medications for athlete’s foot are widely available over-the-counter (OTC). Topical means medication that is applied directly to the area being treated. It is usually down to personal preference as to which form of antifungal medicine you use. Ask your pharmacist which antifungal medicine would be most suitable. Types of antifungal medicine available include: ● terbinafine ● clotrimazole ● econazole ● ketoconazole ● miconazole ● sulconazole Different types of oral antifungal medicines are also available. These need to be prescribed by your GP and include: ● itraconazole ● griseofulvin ● terbinafine Oral antifungal treatment is only recommended for severe cases of infection and if topical antifungal treatment has not worked. Oral medication is suitable for adults but not for children under 16 years of age. Risks There are some risks involved with taking antifungal medication: ● Some oral antifungal treatments are not suitable for children or elderly people. ● Some oral antifungal treatments can interfere with pregnancy and the reproductive system of both men and women. ● Although the self-care steps above can be followed to treat athlete’s foot, the use of tea tree oil is not recommended. Your GP can give you more information and advice about oral antifungal medicines. How to use antifungal medicines NHS Choices puts you in control of your healthcare NHS Choices has been developed to help you make choices about your health, from lifestyle decisions about things like smoking, drinking and excercise, through to the practical aspects of finding and using NHS services when you need them. www.nhs.uk Apply antifungal medication directly to the rash and surrounding area (4-6cm) of normal healthy skin. Make sure that the area is dry before you apply the treatment. Sometimes, your skin may be infected with the fungus without showing any symptoms. It is, therefore, important to treat the surrounding 4-6cm of skin to help prevent re-infection. Always wash your hands before and after you apply the treatment. Apply your antifungal treatment for as long as recommended in the instructions that come with the medicine. Some antifungal medicines have to be used for longer than others to be effective. Although your rash may disappear quickly, this does not necessarily mean that the infection has been completely treated. You may have to use your medication for one to two weeks after your symptoms have gone to ensure that the infection has been successfully treated. Hydrocortisone treatment If your rash is making your skin particularly sore and swollen, you can use an antifungal treatment that contains an ingredient called hydrocortisone. Treatments with low doses of hydrocortisone are available over-the-counter (OTC). However, if your athlete’s foot is more severe, your GP may prescribe a stronger hydrocortisone treatment. Hydrocortisone helps reduce inflammation, as well as easing irritation and itching. Follow the instructions that come with the treatment. Hydrocortisone cannot be used for longer than seven days. If necessary, you will have to use an alternative antifungal treatment (one that does not contain hydrocortisone) until your infection has been completely treated. Always ask your GP or pharmacist for advice before using hydrocortisone if you are pregnant or breastfeeding. When to see your GP If you have developed a secondary infection as a result of your athlete’s foot, you may be prescribed antibiotics to treat it and you will need to see your GP. NHS Choices puts you in control of your healthcare NHS Choices has been developed to help you make choices about your health, from lifestyle decisions about things like smoking, drinking and excercise, through to the practical aspects of finding and using NHS services when you need them. www.nhs.uk.
Recommended publications
  • Antifungals, Topical
    Therapeutic Class Overview Antifungals, Topical INTRODUCTION The topical antifungals are available in multiple dosage forms and are indicated for a number of fungal infections and related conditions. In general, these agents are Food and Drug Administration (FDA)-approved for the treatment of cutaneous candidiasis, onychomycosis, seborrheic dermatitis, tinea corporis, tinea cruris, tinea pedis, and tinea versicolor (Clinical Pharmacology 2018). The antifungals may be further classified into the following categories based upon their chemical structures: allylamines (naftifine, terbinafine [only available over the counter (OTC)]), azoles (clotrimazole, econazole, efinaconazole, ketoconazole, luliconazole, miconazole, oxiconazole, sertaconazole, sulconazole), benzylamines (butenafine), hydroxypyridones (ciclopirox), oxaborole (tavaborole), polyenes (nystatin), thiocarbamates (tolnaftate [no FDA-approved formulations]), and miscellaneous (undecylenic acid [no FDA-approved formulations]) (Micromedex 2018). The topical antifungals are available as single entity and/or combination products. Two combination products, nystatin/triamcinolone and Lotrisone (clotrimazole/betamethasone), contain an antifungal and a corticosteroid preparation. The corticosteroid helps to decrease inflammation and indirectly hasten healing time. The other combination product, Vusion (miconazole/zinc oxide/white petrolatum), contains an antifungal and zinc oxide. Zinc oxide acts as a skin protectant and mild astringent with weak antiseptic properties and helps to
    [Show full text]
  • Therapeutic Class Overview Antifungals, Topical
    Therapeutic Class Overview Antifungals, Topical INTRODUCTION The topical antifungals are available in multiple dosage forms and are indicated for a number of fungal infections and related conditions. In general, these agents are Food and Drug Administration (FDA)-approved for the treatment of cutaneous candidiasis, onychomycosis, seborrheic dermatitis, tinea corporis, tinea cruris, tinea pedis, and tinea versicolor (Clinical Pharmacology 2018). The antifungals may be further classified into the following categories based upon their chemical structures: allylamines (naftifine, terbinafine [only available over the counter (OTC)]), azoles (clotrimazole, econazole, efinaconazole, ketoconazole, luliconazole, miconazole, oxiconazole, sertaconazole, sulconazole), benzylamines (butenafine), hydroxypyridones (ciclopirox), oxaborole (tavaborole), polyenes (nystatin), thiocarbamates (tolnaftate [no FDA-approved formulations]), and miscellaneous (undecylenic acid [no FDA-approved formulations]) (Micromedex 2018). The topical antifungals are available as single entity and/or combination products. Two combination products, nystatin/triamcinolone and Lotrisone (clotrimazole/betamethasone), contain an antifungal and a corticosteroid preparation. The corticosteroid helps to decrease inflammation and indirectly hasten healing time. The other combination product, Vusion (miconazole/zinc oxide/white petrolatum), contains an antifungal and zinc oxide. Zinc oxide acts as a skin protectant and mild astringent with weak antiseptic properties and helps to
    [Show full text]
  • Sulconazole Nitrate)
    Federal Employee Program® 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.90.14 Section: Prescription Drugs Effective Date: April 1, 2021 Subsection: Topical Products Original Policy Date: June 5, 2015 Subject: Exelderm Page: 1 of 4 Last Review Date: March 12, 2021 Exelderm Description Exelderm (sulconazole nitrate) Background Exelderm is used to treat skin infections such as jock itch (tinea cruris) and ringworm (tinea corporis). This medication is also used to treat a skin condition known astinea (pityriasis versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Sulconazole is an azole antifungal that works by preventing the growth of fungus (1). Regulatory Status FDA-approved indications: Exelderm is an azole antifungal indicated for the treatment of tinea tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, and for the treatment of tinea versicolor. Effectiveness has not been proven in tinea pedis (athlete’s foot) (1). Safety and effectiveness of Exelderm in pediatric patients has not been established (1). Related policies Ecoza, Ertaczo, Jublia, Kerydin, Luzu, Oxistat Policy This policy statement applies to clinical review performed for pre-service (Prior Approval, Precertification, Advanced Benefit Determination, etc.) and/or post-service claims. 5.90.14 Section: Prescription Drugs Effective Date: April 1, 2021 Subsection: Topical Products Original Policy Date: June 5, 2015 Subject: Exelderm Page: 2 of 4 Exelderm may be considered medically necessary in patients 18 years of age or older with tinea cruris, tinea corporis and tinea versicolor and when the conditions indicated below are met.
    [Show full text]
  • Evidence-Based Danish Guidelines for the Treatment of Malassezia- Related Skin Diseases
    Acta Derm Venereol 2015; 95: 12–19 SPECIAL REPORT Evidence-based Danish Guidelines for the Treatment of Malassezia- related Skin Diseases Marianne HALD1, Maiken C. ARENDRUP2, Else L. SVEJGAARD1, Rune LINDSKOV3, Erik K. FOGED4 and Ditte Marie L. SAUNTE5; On behalf of the Danish Society of Dermatology 1Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, 2 Unit for Mycology, Statens Serum Institut, 3The Dermatology Clinic, Copen- hagen, 4The Dermatology Clinic, Holstebro, and 5Department of Dermatology, Roskilde Hospital, University of Copenhagen, Denmark Internationally approved guidelines for the diagnosis including those involving Malassezia (2), guidelines and management of Malassezia-related skin diseases concerning the far more common skin diseases are are lacking. Therefore, a panel of experts consisting of lacking. Therefore, a panel of experts consisting of dermatologists and a microbiologist under the auspi- dermatologists and a microbiologist appointed by the ces of the Danish Society of Dermatology undertook a Danish Society of Dermatology undertook a data review data review and compiled guidelines for the diagnostic and compiled guidelines on the diagnostic procedures procedures and management of pityriasis versicolor, se- and management of Malassezia-related skin diseases. borrhoeic dermatitis and Malassezia folliculitis. Main The ’head and neck dermatitis’, in which hypersensi- recommendations in most cases of pityriasis versicolor tivity to Malassezia is considered to be of pathogenic and seborrhoeic dermatitis include topical treatment importance, is not included in this review as it is restric- which has been shown to be sufficient. As first choice, ted to a small group of patients with atopic dermatitis. treatment should be based on topical antifungal medica- tion.
    [Show full text]
  • Application Number
    CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 205175Orig1s000 MEDICAL REVIEW(S) CLINICAL REVIEW Application Type NDA Application Number(s) 205-175 Priority or Standard Standard Submit Date(s) December 22, 2012 Received Date(s) December 24, 2012 PDUFA Goal Date October 24, 2013 Division / Office DDDP/ODE III Reviewer Name(s) Amy S. Woitach, D.O. Review Completion Date September 20, 2013 Established Name Econazole Nitrate Foam, 1% (Proposed) Trade Name Ecoza Therapeutic Class Antifungal Applicant Amderma Pharmaceuticals Formulation(s) Topical Foam Dosing Regimen Once daily for 4 weeks Indication(s) Interdigital tinea pedis Intended Population(s) Ages 12 years and older Template Version: March 6, 2009 Reference ID: 3376891 Clinical Review Amy S. Woitach, D.O. NDA 205-175 Econazole Nitrate Foam (Ecoza) 1% Table of Contents 1 RECOMMENDATIONS/RISK BENEFIT ASSESSMENT......................................... 7 1.1 Recommendation on Regulatory Action ............................................................. 7 1.3 Recommendations for Postmarket Risk Evaluation and Mitigation Strategies ... 8 1.4 Recommendations for Postmarket Requirements and Commitments ................ 8 2 INTRODUCTION AND REGULATORY BACKGROUND ........................................ 9 2.1 Product Information .......................................................................................... 10 2.2 Tables of Currently Available Treatments for Tinea Pedis................................ 11 2.3 Availability of Proposed Active Ingredient in the United States
    [Show full text]
  • List of Off-Patent, Off-Exclusivity Drugs Without an Approved Generic
    List of Off-Patent, Off-Exclusivity Drugs without an Approved Generic To improve transparency and encourage the development and submission of abbreviated new drug applications (ANDAs) for drugs with limited competition, FDA is publishing a list, consistent with the methodology described below, of approved new drug application (NDA) drug products that are off-patent and off-exclusivity, and for which the FDA has not approved an ANDA referencing that NDA drug product. Part I of the list identifies those drug products for which FDA could immediately accept an ANDA without prior discussion. Part II identifies drug products for which ANDA development or approval may raise potential legal, regulatory, or scientific issues that should be addressed with the Agency prior to considering submission of an ANDA. The Appendix identifies NDA drug products that were removed from Part I or Part II of the list because one or more ANDAs referencing such NDA drug products have been approved since the previous list publication. Sponsors wishing to pursue approval of ANDAs referencing drug products identified in Part II of this list generally should submit an initial inquiry to the Office of Generic Drugs at [email protected]. Sponsors may be referred to the Office of New Drugs under certain circumstances, for example if the product is not eligible for submission or approval as an ANDA but may be considered for submission under another abbreviated approval pathway. Sponsors should identify the product’s established name and NDA number in any inquiry. • For some products in Part II of the list, submission and/or approval of an ANDA via the 505(j) pathway may not be appropriate; section 505(b)(2) of the FD&C Act may be an appropriate abbreviated approval pathway for such products.
    [Show full text]
  • Compounding for Scalp Disorders and Conditions
    COMPOUNDING FOR SCALP DISORDERS AND CONDITIONS ACPE UAN#: 0145-9999-12-007-H04-P, 0145-9999-12-007-H04-T 1.0 Contact Hours (0.1 CEU), Expires 03/19/2015 Activity Type: Knowledge Y. Pramar, Ph.D., Professor of Pharmaceutics Xavier University of Louisiana, College of Pharmacy, New Orleans, Louisiana. Reprinted with permission of the author and the Louisiana Pharmacists Association where this article originally appeared. This activity may appear in other state pharmacy association journals. Participants should not seek credit for duplicate content. Goals: The goals of this article are to provide information on the physiology and disorders of the scalp, and typical drug therapy used to treat these disorders. Objectives Pharmacists & Technicians: At the conclusion of this lesson, the reader should be able to: 1. Discuss the physiology of the scalp and the function of the sebum, sweat glands and pores. 2. List at least five disorders/conditions of the scalp. 3. Describe different treatment approaches used in scalp disorders. 4. Recognize various formulations used in the treatment of seborrheic dermatitis, dandruff, psoriasis, hair loss, lice and ringworm. Introduction the hair follicle. Sebum consists of fatty acids and other Scalp disorders may be painful, annoying, unsightly and substances and protects the skin by reducing the embarrassing. Scalp problems may require short-term evaporation of water from the skin and blocks the treatment, but many of them need long-term therapy penetration of excess water into the skin. This sebum is over months, and sometimes years. Compounding one of two constituents making up the lipid film present pharmacists have a significant role in achieving on the skin surface, the other being the lipids of the successful therapeutic outcomes in this emerging field.
    [Show full text]
  • Prescription Drug List
    Kaiser Permanente Hawaii PRESCRIPTION DRUG LIST Four-tier drug benefit This formulary list provides coverage information about the drugs covered under our Four-Tier Pharmacy Plan. The list is organized in alphabetical order and each drug name includes a color box that shows which tier the drug falls within. If your prescription drug is not on this list, it is not covered under our four-tier benefit structure. TIER 1 TIER 2 TIER 3 TIER 4 Generic drugs Generic drugs Brand-name drugs Specialty drugs on the published list. not included in Tier 1. on the published list. on the published list. Under the four-tier benefit structure, you pay a lower copayment for medically necessary generic medications and a higher copayment for specialty medications. Your copayments depend on your plan. For information about your prescription copayments, please review your Summary of Benefits. If your physician has prescribed a medically necessary generic medication, but you prefer to have the brand-name drug, you will pay the full member rate for the brand-name medication. Certain drugs may deviate from the four-tier benefit structure. See the following definitions for abbreviations linked to certain drugs on this list: • ACA = Under the Affordable Care Act (ACA), certain over-the-counter and prescription drugs are covered at no charge when prescribed by a physician for preventative purposes. • HCR = Certain Food and Drug Administration-approved contraceptive drugs and devices are available at no charge under health care reform (HCR). • PAH = There are some drugs that are covered only for pulmonary arterial hypertension (PAH). • TC = There are no charges for approved tobacco cessation (TC) products.
    [Show full text]
  • Skin Diseases Associated with Malassezia Species
    CLINICAL REVIEW Skin diseases associated with Malassezia species AdityaK.Gupta,MD,PhD,FRCPC,a,b Roma Batra, MPhil, PhD,b Robyn Bluhm, HBSc, MA,b,c Teun Boekhout, PhD,d and Thomas L. Dawson, Jr, PhDe Toronto and London, Ontario, Canada; Utrecht, the Netherlands; and Cincinnati, Ohio The yeasts of the genus Malassezia have been associated with a number of diseases affecting the human skin, such as pityriasis versicolor, Malassezia (Pityrosporum) folliculitis, seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and—less commonly—with other dermatologic disorders such as confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection. The study of the clinical role of Malassezia species has been surrounded by controversy because of their fastidious nature in vitro, and relative difficulty in isolation, cultivation, and identification. Many studies have been published in the past few years after the taxonomic revision carried out in 1996 in which 7 species were recognized. Two new species have been recently described, one of which has been isolated from patients with atopic dermatitis. This review focuses on the clinical, mycologic, and immunologic aspects of the various skin diseases associated with Malassezia. It also highlights the importance of individual Malassezia species in the different dermatologic disorders related to these yeasts. (J Am Acad Dermatol 2004;51:785-98.) lthough yeasts of the genus Malassezia are also be affected by the clinical conditions associated a normal part of the skin flora, they are also with Malassezia. However, in the vast majority of Aassociated with several common dermato- patients, skin involvement is localized to specific logic conditions.
    [Show full text]
  • Download Product Insert (PDF)
    PRODUCT INFORMATION Sulconazole (nitrate) Item No. 23800 Cl CAS Registry No.: 61318-91-0 Formal Name: 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4- dichlorophenyl)ethyl]-1H-imidazole, mononitrate Synonym: RS 44872 MF: C H Cl N S • HNO 18 15 3 2 3 N FW: 460.8 S Cl Purity: ≥95% N UV/Vis.: λmax: 219 nm Supplied as: A crystalline solid Storage: -20°C • HNO3 Cl Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Laboratory Procedures Sulconazole (nitrate) is supplied as a crystalline solid. A stock solution may be made by dissolving the sulconazole (nitrate) in the solvent of choice. Sulconazole (nitrate) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of sulconazole (nitrate) in ethanol is approximately 0.1 mg/ml and approximately 25 mg/ml in DMSO and DMF. Sulconazole (nitrate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, sulconazole (nitrate) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Sulconazole (nitrate) has a solubility of approximately 0.33 mg/ml in a 1:2 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Description Sulconazole is an azole antifungal that is active against dermatophyte fungal species, including isolates of various Candida species.1 It acts as a non-specific inhibitor of styrene metabolism by cytochrome P450 (CYP450) enzymes, with Ki values ranging from 0.008 to 3.5 µM against various CYP450 isoforms in human lymphoblast microsomes in vitro.2,3 In rat spleen microsomes, it inhibits the activity of heme oxygenase 1 4 with an IC50 value of 1.1 µM.
    [Show full text]
  • Therapy of Skin, Hair and Nail Fungal Infections
    Journal of Fungi Review Therapy of Skin, Hair and Nail Fungal Infections Roderick Hay Kings College London, London SE5 9RS, UK; [email protected] Received: 25 June 2018; Accepted: 10 August 2018; Published: 20 August 2018 Abstract: Treatment of superficial fungal infections has come a long way. This has, in part, been through the development and evaluation of new drugs. However, utilising new strategies, such as identifying variation between different species in responsiveness, e.g., in tinea capitis, as well as seeking better ways of ensuring adequate concentrations of drug in the skin or nail, and combining different treatment methods, have played equally important roles in ensuring steady improvements in the results of treatment. Yet there are still areas where we look for improvement, such as better remission and cure rates in fungal nail disease, and the development of effective community treatment programmes to address endemic scalp ringworm. Keywords: dermatophytes; cutaneous candidiasis; Malassezia infection; treatment; onychomycosis 1. Introduction Fungal infections of the skin and its adnexal structures, such as hair and nails, are common in all regions of the world. Yet over the last 40 years, there have been huge advances in the management of these conditions, starting from a time when most of the available therapies were simple antiseptics with some antifungal activity, to the present day where there is a large and growing array of specific antifungal antimicrobials. Although the course to modern treatment has not been without its problems, the complications, commonly encountered amongst antibacterials, particularly drug resistance, have not had a major impact on the currently used antifungals, with the possible exception of the superficial Candida infections, where azole resistance is well recognised.
    [Show full text]
  • Disruption of the NF-B/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation
    cells Article Disruption of the NF-κB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation 1,2, 3, 1,3 1,2,3, Hack Sun Choi y, Ji-Hyang Kim y, Su-Lim Kim and Dong-Sun Lee * 1 School of Biomaterials Sciences and Technology, College of Applied Life Science, Jeju National University, Jeju 63243, Korea 2 Subtropical/tropical Organism Gene Bank, Jeju National University, Jeju 63243, Korea 3 Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea * Correspondence: [email protected] These authors contributed equally to this work. y Received: 5 August 2019; Accepted: 29 August 2019; Published: 30 August 2019 Abstract: Breast cancer stem cells (BCSCs) are tumor-initiating cells that possess the capacity for self-renewal. Cancer stem cells (CSCs) are responsible for poor outcomes caused by therapeutic resistance. In our study, we found that sulconazole—an antifungal medicine in the imidazole class—inhibited cell proliferation, tumor growth, and CSC formation. This compound also reduced the frequency of cells expressing CSC markers (CD44high/CD24low) as well as the expression of another CSC marker, aldehyde dehydrogenase (ALDH), and other self-renewal-related genes. Sulconazole inhibited mammosphere formation, reduced the protein level of nuclear NF-κB, and reduced extracellular IL-8 levels in mammospheres. Knocking down NF-κB expression using a p65-specific siRNA reduced CSC formation and secreted IL-8 levels in mammospheres. Sulconazole reduced nuclear NF-κB protein levels and secreted IL-8 levels in mammospheres. These new findings show that sulconazole blocks the NF-κB/IL-8 signaling pathway and CSC formation.
    [Show full text]