Aryan Migration: New Genetic Study Makes out of India Theory Backed by Hindutva Supporters Unlikely

Total Page:16

File Type:pdf, Size:1020Kb

Aryan Migration: New Genetic Study Makes out of India Theory Backed by Hindutva Supporters Unlikely 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely Sunday, May 20th 2018 Home Video The Latest The Reel The Field Magazine Pulse In Pictures Bookshop Trending Sections Newsletters Aryan migration: Everything you need to know about the new study on Indian genetics GENETICS The study says some sort of migration did indeed take place into India and that the Indus Valley civilisation is key to all South Asian populations. by Rohan Venkataramakrishnan Published Apr 02, 2018 · 10:59 am https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 1/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely Apr 02, 2018 · 10:59 am Rohan Venkataramakrishnan A new paper authored by 92 scientists from around the globe that was posted online this weekend could settle some major questions about the subcontinent’s history and what that means for various theories of Indian civilisation. The paper, titled “The Genomic Formation of South and Central Asia” which still has to go through peer review, uses genetics to examine the ancestry of ancient inhabitants of the subcontinent. Below is a quick summary of what you need to know. Who authored the study? There are 92 named authors on the study including scholars from Harvard, MIT, the Russian Academy of Science, the Birbal Sahni Institute of Paleosciences in Lucknow, the Deccan College, the Max Planck Institute, the Institute for Archaeological Research in Uzbekistan and the Centre for Cellular and Molecular Biology, Hyderabad. Among the co-directors of the study is geneticist David Reich, whose new book has inspired much recent discussion about ancient human history and racial theory. How was the study conducted? The researchers looked at genome-wide data from 612 ancient individuals, meaning DNA samples of people that lived millennia ago. These included samples from eastern Iran, an area called Turan that now covers Uzbekistan, Turkmenistan and Tajikistan, Kazakhstan and South Asia. Of the 612, the DNA of 362 ancient individuals was being examined for the first time. They then compared this data with that taken from present-day individuals, including 246 distinct groups in South Asia. https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 2/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely What were they looking for? A lack of sufficient ancient DNA as well as proper inquiry into the matter has meant that we still do not understand how Central and South Asian populations were formed. There have been various theories about this, with some very closely connected to politics both in South Asia and abroad. The Nazis, for example, helped propagate the Aryan Invasion Theory in which blue-eyed fair people swept into the Indian subcontinent on horses, conquering everyone they saw along the way. Hindutva proponents have argued the opposite altogether, what is known as the Out- of-India theory, claiming that, if anything, Indo-European languages originated in India and spread out westward from there. DNA and other human science based research has thrown up confusing signals in the past, with mitochondrial DNA, which is only transferred by females being mostly unique to the subcontinent. This suggested that the inhabitants of India have been indigenous for thousands of years. However, Y chromosomes, which are passed from male to male, showed much more connection to West Eurasians, whether Europeans, people of the Irani plateau or Central Asians. Amid all this, there is the question of whom the Indus Valley people were. Were they more connected to those we now know as Dravidians, only to be pushed south by migrating Aryans? Or were they themselves Aryans, who eventually moved southward? In many ways, the study set out to resolve this contradiction and answer some part of the question: Who are the people of the subcontinent and how did they get there? What did they find? The paper, which you can read in full here, builds on the genetic understanding that there were two separate groups in ancient India: Ancestral North Indians and Ancestral South Indians, or ANI and ASI. These two groups were, as Reich explains in https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 3/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely his new book, “as different from each other as Europeans and East Asians are today.” But where do these two populations, which solidify in around 2000 BCE, come from? There are three potential groupings that, when mixed in various combinations, could be responsible for the creation of the Ancestral North Indian and Ancestral South Indian Populations. The first are South Asian hunter-gatherers, described in this study as Ancient Ancestral South Indians or AASI, the oldest people of the subcontinent, related to modern-day Andaman islanders. Then there are Iranian agriculturists, who were known to have come to the subcontinent, possibly bringing certain forms of cultivation of wheat and barley with them. And finally, there are the Steppe pastoralists, the inhabitants of the vast Central Asian grasslands to the north of Afghanistan, who were previously known as ‘Aryans.’ There is another, important population with South Asian connections that sits somewhere amidst these three: the Indus Valley population. In Turan, the area north of modern-day Iran also known as the Bactria-Margiana Archaeological Complex, there was a huge community of ancient people who seem to have little genetic connection with the inhabitants of the subcontinent. Yet the authors found three individuals from this ancient complex that did have some connection to India, specifically an ancestry mix of Iranian agriculturists and South Asian hunter- gatherers or Ancient Ancestral South Indians. This matched individuals from the Swat Valley in Pakistan, another Indus Valley site. Because the researchers didn’t have direct access to ancient DNA from India’s Indus Valley sites, the paper prefers to call them Indus Valley periphery individuals. These three individuals are key to the findings. https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 4/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely Where does the Indus Valley fit in? The reason the researchers call them Indus Valley periphery individuals is because they cannot be sure that their genetic makeup is the same as most of those who lived in the Indus Valley, because they did not have access to ancient DNA from Indian sites. But for the most part they seem to use these individuals as proxies for the people of that civilisation. The make-up of Indus Valley periphery individuals is straightforward: a mixture of Iranian agriculturists and the South Asian hunter-gatherers, or Ancient Ancestral South Indians. The study finds that these two ancestries are also there in both of the subsequent populations, of Ancestral North Indians and Ancestral South Indians, except for a couple of key differences. First Ancestral South Indians have the same basic mix: South Asian hunter- gatherers and Iranian agriculturists, with a higher amount of the former. https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 5/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely And second, importantly, Ancestral North Indians have one more ancestry mixed in that is not to be found in Ancestral South Indians: the Steppe pastoralists or, to use the old term, Aryans. What does the paper conclude? In simple terms, the mixing of Iranian agriculturists and South Asian hunter- gatherers first created the Indus Valley population. Then around the 2nd millennium BCE, Steppe pastoralists moved south towards the subcontinent encountering the Indus Valley population in a manner that was likely to have caused some amount of upheaval. What appears to happen afterwards is that some of the Indus Valley population moves further south, mixing more with South Asian hunter-gatherers to create the Ancestral South Indian population Meanwhile, in the north, the Steppe pastoralists are mixing with the Indus Valley population to create the Ancestral North Indian grouping. Most subsequent South Asian populations are then a result of further mixing between Ancestral North Indians and Ancestral South Indians. This also means that the people of the Indus Valley Civilisation are the bridge to most extant Indian populations. “By co-analyzing ancient DNA and genomic data from diverse present-day South Asians, we show that Indus Periphery related people are the single most important source of ancestry in South Asia.” What does all this mean? Many things that would be hard to summarise. Journalist Tony Joseph, explains a number of implications in this piece, but here are a few main ones: Some form of “Aryan” migration did take place, even if that term is not used. The introduction of Steppe pastoralists into the subcontinent might have been the way https://scroll.in/article/874102/aryan-migration-everything-you-need-to-know-about-the-new-study-on-indian-genetics 6/8 5/20/2018 Aryan migration: New genetic study makes Out of India theory backed by Hindutva supporters unlikely what we know as Indo-European language and culture spread, since it was the same lot of Steppe peoples that also moved West into Europe. Moreover, there may be connection between the Steppe migration and priestly caste and culture.
Recommended publications
  • Ancient DNA from Chalcolithic Israel Reveals the Role of Population Mixture in Cultural Transformation
    Corrected: Publisher correction ARTICLE DOI: 10.1038/s41467-018-05649-9 OPEN Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation Éadaoin Harney1,2,3, Hila May4,5, Dina Shalem6, Nadin Rohland2, Swapan Mallick2,7,8, Iosif Lazaridis2,3, Rachel Sarig5,9, Kristin Stewardson2,8, Susanne Nordenfelt2,8, Nick Patterson7,8, Israel Hershkovitz4,5 & David Reich2,3,7,8 1234567890():,; The material culture of the Late Chalcolithic period in the southern Levant (4500–3900/ 3800 BCE) is qualitatively distinct from previous and subsequent periods. Here, to test the hypothesis that the advent and decline of this culture was influenced by movements of people, we generated genome-wide ancient DNA from 22 individuals from Peqi’in Cave, Israel. These individuals were part of a homogeneous population that can be modeled as deriving ~57% of its ancestry from groups related to those of the local Levant Neolithic, ~17% from groups related to those of the Iran Chalcolithic, and ~26% from groups related to those of the Anatolian Neolithic. The Peqi’in population also appears to have contributed differently to later Bronze Age groups, one of which we show cannot plausibly have descended from the same population as that of Peqi’in Cave. These results provide an example of how population movements propelled cultural changes in the deep past. 1 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. 2 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. 3 The Max Planck–Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, Cambridge, MA 02138, USA.
    [Show full text]
  • THE TEXTS, POLITICAL HISTORY and ADMINISTRATION Till C. 200 BC
    History of Ancient India Volume III THE TEXTS, POLITICAL HISTORY AND ADMINISTRATION Till c. 200 BC Editors Dilip K. Chakrabarti and Makkhan Lal Vivekananda International Foundation New Delhi Aryan Books International New Delhi Cataloging in Publication Data—DK [Courtesy: D.K. Agencies (P) Ltd. <[email protected]>] History of ancient India / editors, Dilip K. Chakrabarti and Makkhan Lal. v. 3 cm. Contributed articles. Includes index. Contents: v. 3. The texts, political history and administration, till c. 200 BC. ISBN 9788173054822 1. India—History. 2. India—Politics and government. I. Chakrabarti, Dilip K., 1941- II. Makkhan Lal, 1954- III. Vivekananda International Foundation. DDC 954 23 ISBN: 978-81-7305-482-2 © Vivekananda International Foundation All rights reserved. No part of this book may be reproduced, utilised in any form or by any means, electronic and mechanical, including photocopying, recording or by any information storage and retrieval system without prior permission of the authors and the publishers. Responsibility for statements made and visuals provided in the various papers rest solely with the contributors. The views expressed by individual authors are not necessarily those of the editors or of publishers. First Published in 2014 by Vivekananda International Foundation 3, San Martin Marg, Chanakyapuri, New Delhi - 110 021 Tel.: 24121764, 24106698; Fax: 91-11-43115450 E-mail: [email protected] www.vifindia.org in association with Aryan Books International Pooja Apartments, 4B, Ansari Road, New Delhi - 110 002 Tel.: 23287589, 23255799; Fax: 91-11-23270385 E-mail: [email protected] www.aryanbooks.co.in Designed and Printed in India at ABI Prints & Publishing Co., New Delhi.
    [Show full text]
  • An Ancient DNA Pacific Journey: a Case Study of Collaboration Between Archaeologists and Geneticists
    World Archaeology ISSN: 0043-8243 (Print) 1470-1375 (Online) Journal homepage: https://www.tandfonline.com/loi/rwar20 An ancient DNA Pacific journey: a case study of collaboration between archaeologists and geneticists Matthew Spriggs & David Reich To cite this article: Matthew Spriggs & David Reich (2020): An ancient DNA Pacific journey: a case study of collaboration between archaeologists and geneticists, World Archaeology, DOI: 10.1080/00438243.2019.1733069 To link to this article: https://doi.org/10.1080/00438243.2019.1733069 Published online: 17 Mar 2020. Submit your article to this journal Article views: 29 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=rwar20 WORLD ARCHAEOLOGY https://doi.org/10.1080/00438243.2019.1733069 ARTICLE An ancient DNA Pacific journey: a case study of collaboration between archaeologists and geneticists Matthew Spriggs a,b and David Reich c,d,e,f aCollege of Arts and Social Sciences, The Australian National University, Canberra, Australia; bVanuatu National Museum, Vanuatu Cultural Centre, Port Vila, Vanuatu; cDepartment of Genetics, Harvard Medical School, Boston, MA, USA; dHoward Hughes Medical Institute, Boston, MA, USA; eMedical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; fDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA ABSTRACT KEYWORDS We present a case-study of a collaboration between archaeologists and geneticists Ancient DNA; that has helped settle a long-standing controversy and opened up new research palaeogenomics; questions for the Pacific region. The work provided insights into the history of collaboration between human settlement and cultural changes in Vanuatu in the western Pacific, which in archaeologists and geneticists; interdisciplinary turn shed light on the origins of the cultural and linguistic diversity that charac- perspectives terizes the archipelago.
    [Show full text]
  • Qnas with David Reich QNAS
    QNAS QnAs with David Reich QNAS Beth Azar, Science Writer Harvard Medical School geneticist David Reich feels lucky to have found paleogenetics, a field that com- bines his love of history with his love of science. Reich plumbs data, collected by transcribing ancient DNA, to learn about human history, including migration pat- terns, social structures, health, and disease. Paleoge- netics has exploded in the last few years, with massive increases in the world’s dataset of ancient DNA. For his work in this field, Reich won the 2019 National Acad- emy of Sciences Award in Molecular Biology. PNAS recently spoke with Reich about his role in invigorating the field. PNAS: How did you become interested in analyzing ancient DNA as a means to understand human history? Reich: I’ve always been interested in human history. I began college majoring in sociology and history. I switched to physics in my third year and then did a fifth undergraduate year in biochemistry at Oxford. I found work in a [laboratory] with David Goldstein (now at Columbia University) who was studying human his- David Reich. Image courtesy of Howard Hughes Medical tory with genetic data. It was immediately interesting. I Institute/Bizuayehu Tesfaye. ended up staying for what became a PhD. But I en- tered the field before its time had come. We were PNAS: Which of your findings have been the most trapped by the small amount of data, and we were surprising? trapped by the fact that our samples were from the ’ present. I left the field and went to medical school at Reich: I ll list three.
    [Show full text]
  • The Genomic History of Southeastern Europe
    bioRxiv preprint doi: https://doi.org/10.1101/135616; this version posted September 19, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 The Genomic History of Southeastern Europe 2 Iain Mathieson† (1), Songül Alpaslan Roodenberg (1), Cosimo Posth (2,3), Anna Szécsényi- 3 Nagy (4), Nadin Rohland (1), Swapan Mallick (1,5), Iñigo Olalde (1), Nasreen 4 Broomandkhoshbacht (1,5), Francesca Candilio (6), Olivia Cheronet (6,7), Daniel Fernandes 5 (6,8), Matthew Ferry (1,5), Beatriz Gamarra (6), Gloria González Fortes (9), Wolfgang Haak 6 (2,10), Eadaoin Harney (1,5), Eppie Jones (11,12), Denise Keating (6), Ben Krause-Kyora 7 (2), Isil Kucukkalipci (3), Megan Michel (1,5), Alissa Mittnik (2,3), Kathrin Nägele (2), 8 Mario Novak (6,13), Jonas Oppenheimer (1,5), Nick Patterson (14), Saskia Pfrengle (3), 9 Kendra Sirak (6,15), Kristin Stewardson (1,5), Stefania Vai (16), Stefan Alexandrov (17), 10 Kurt W. Alt (18,19,20), Radian Andreescu (21), Dragana Antonović (22), Abigail Ash (6), 11 Nadezhda Atanassova (23), Krum Bacvarov (17), Mende Balázs Gusztáv (4), Hervé 12 Bocherens (24,25), Michael Bolus (26), Adina Boroneanţ (27), Yavor Boyadzhiev (17), 13 Alicja Budnik (28), Josip Burmaz (29), Stefan Chohadzhiev (30), Nicholas J. Conard (31,25), 14 Richard Cottiaux (32), Maja Čuka (33), Christophe Cupillard (34,35), Dorothée G. Drucker 15 (25), Nedko Elenski (36), Michael Francken (37), Borislava Galabova (38), Georgi 16 Ganetovski (39), Bernard Gély (40), Tamás Hajdu (41), Veneta Handzhyiska (42), Katerina 17 Harvati (37,25), Thomas Higham (43), Stanislav Iliev (44), Ivor Janković (13,45), Ivor 18 Karavanić (46,45), Douglas J.
    [Show full text]
  • Q&A: Where Did the Neanderthals
    Harris and Nielsen BMC Biology (2017) 15:73 DOI 10.1186/s12915-017-0414-2 QUESTION AND ANSWER Open Access Q&A: Where did the Neanderthals go? Kelley Harris1* and Rasmus Nielsen2,3* flow from humans into Neanderthals occurred much Abstract earlier, closer to 100,000 years ago [4]. Genomic evidence has demonstrated that humans and Neanderthals interbred. Today, the genomes of But the Neanderthals are not here today. What do – most individuals outside Africa contain 2 3% we know about when and how they went extinct? Neanderthal DNA. However, it is still hotly debated From the fossil record, we know that the Neanderthal why the Neanderthals went extinct and if humans population started to decline around 40,000 years ago. contributed to the Neanderthal extinction. In this There is some disagreement about how long they coex- Q&A we explore what genomic data might have to isted with humans—the species might have completely say about this issue. disappeared as long ago as 39,000 years ago, but some radiocarbon dating studies have suggested that Neander- In 2010 Svante Pääbo and colleagues published a thals might have survived in Asia as recently as 24,000 paper showing that humans and Neanderthals years ago. Many different factors probably contributed to interbred. Does that conclusion still hold true their extinction, but their decline conspicuously coincides today? with the movement of anatomically modern humans into Yes, more evidence of human/Neanderthal interbreeding Europe and Asia [5]. has been building up every year. The initial 2010 finding by Pääbo and colleagues [1] was remarkable in that it What theories have anthropologists then was based on only a single ‘draft’ Neanderthal genome proposed that could explain the extinction? that was highly degraded but still contained useful genetic Many different hypotheses have been proposed to ex- information.
    [Show full text]
  • Who We Are and How We Got Here : Ancient DNA and the New Science of the Human Past / David Reich
    Copyright © 2018 by David Reich and Eugenie Reich All rights reserved. Published in the United States by Pantheon Books, a division of Penguin Random House LLC, New York, and distributed in Canada by Random House of Canada, a division of Penguin Random House Canada Limited, Toronto. Pantheon Books and colophon are registered trademarks of Penguin Random House LLC. Library of Congress Cataloging-in-Publication Data Name: Reich, David [date], author. Title: Who we are and how we got here : ancient DNA and the new science of the human past / David Reich. Description: First edition. New York : Pantheon Books, [2018]. Includes bibliographical references and index. Identifiers: LCCN 2017038165. ISBN 9781101870327 (hardcover). ISBN 9781101870334 (ebook). Subjects: LCSH: Human genetics—Popular works. Genomics—Popular works. DNA—Analysis. Prehistoric peoples. Human population genetics. BISAC: SCIENCE/Life Sciences/Genetics & Genomics. SCIENCE/Life Sciences/Evolution. SOCIAL SCIENCE/Anthropology/General. Classification: LCC QH431 .R37 2018. DDC 572.8/6—dc23. LC record available at lccn.loc.gov/2017038165. Ebook ISBN 9781101870334 www.pantheonbooks.com Cover design by Oliver Uberti Illustrations and map by Oliver Uberti v5.2 a 6 The Collision That Formed India The Fall of the Indus Civilization In the oldest text of Hinduism, the Rig Veda, the warrior god Indra rides against his impure enemies, or dasa, in a horse-drawn chariot, destroys their fortresses, or pur, and secures land and water for his people, the arya, or Aryans.1 Composed between four thousand and three thousand years ago in Old Sanskrit, the Rig Veda was passed down orally for some two thousand years before being written down, much like the Iliad and Odyssey in Greece, which were composed several hundred years later in another early Indo-European language.2 The Rig Veda is an extraordinary window into the past, as it provides a glimpse of what Indo-European culture might have been like in a period far closer in time to when these languages radiated from a common source.
    [Show full text]
  • Toward a New History and Geography of Human Genes
    Feature Review Toward a new history and geography of human genes informed by ancient DNA 1,2 3,4,5 Joseph K. Pickrell and David Reich 1 New York Genome Center, New York, NY, USA 2 Department of Biological Sciences, Columbia University, New York, NY, USA 3 Department of Genetics, Harvard Medical School, Boston, MA, USA 4 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA 5 Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA Genetic information contains a record of the history of which propose that the present-day inhabitants of a region our species, and technological advances have trans- descend from people who arrived during periods of tech- formed our ability to access this record. Many studies nological or cultural change, replacing the previous inha- have used genome-wide data from populations today to bitants. learn about the peopling of the globe and subsequent In archaeology, this debate has played out around the adaptation to local conditions. Implicit in this research is issue of whether sudden changes in material culture ap- the assumption that the geographic locations of people parent in the archaeological record can be attributed to the today are informative about the geographic locations of spread of culture or to population movements: ‘pots versus their ancestors in the distant past. However, it is now people’ [1]. In physical anthropology, the debate has played clear that long-range migration, admixture, and popula- out around the issue of whether changes in morphological tion replacement subsequent to the initial out-of-Africa characters over time are due to in situ evolution or to the expansion have altered the genetic structure of most of arrival of new populations (e.g., [2]).
    [Show full text]
  • Neanderthals Had Outsize Effect on Human Biology from Skin Disorders to the Immune System, Sex with Archaic Species Changed Homo Sapiens
    NEWS IN FOCUS ANTHROPOLOGY Neanderthals had outsize effect on human biology From skin disorders to the immune system, sex with archaic species changed Homo sapiens. BY EWEN CALLAWAY ur ancestors were not a picky bunch. Overwhelming genetic evidence XIN LU/GETTY shows that Homo sapiens had sex with ONeander­thals, Denisovans and other archaic relatives. Now researchers are using large genomics studies to unravel the decidedly mixed contributions that these ancient romps made to human biology — from the ability of H. sapiens to cope with environments outside Africa, to the tendency of modern humans to get asthma, skin diseases and maybe even depression. The proportion of the human genome that comes from archaic relatives is small. The genomes of most Europeans and Asians are 2–4% Neanderthal1, with Denisovan DNA making up about 5% of the genomes of Mela­ nesians2 and Aboriginal Australians3. DNA slivers from other distant relatives probably pepper a variety of human genomes4. A gene variant from archaic humans helps modern-day Tibetans to cope with high altitudes. But these sequences may have had an out­ size effect on human biology. In some cases, and Tony Capra, evolutionary geneticists at and depression, obesity and certain skin disor­ they are very different from the correspond­ Vanderbilt University in Nashville, Tennessee, ders, with some variants being associated with ing H. sapiens DNA, notes population geneti­ turned to genome-wide association studies an increased risk and others with a reduced cist David Reich of Harvard Medical School (GWAS) that had already compared thousands risk. Simonti presented the data at the annual in Boston, Massachusetts — which makes it of DNA variants in people with and without a meeting of the Society for Molecular Biology more likely that they could introduce use­ certain disease or condition.
    [Show full text]
  • DNA Analysis of an Early Modern Human from Tianyuan Cave, China
    DNA analysis of an early modern human from Tianyuan Cave, China Qiaomei Fua,b,1, Matthias Meyerb, Xing Gaoa, Udo Stenzelb, Hernán A. Burbanob,c, Janet Kelsob, and Svante Pääboa,b,1 aChinese Academy of Sciences–Max Planck Society Joint Laboratory for Human Evolution, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 100044 Beijing, China; bDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany; and cDepartment of Molecular Biology, Max Planck Institute for Developmental Biology, D-72076 Tübingen, Germany Contributed by Svante Pääbo, December 11, 2012 (sent for review September 21, 2012) Hominins with morphology similar to present-day humans appear of human origin (SI Text, section 1 and Table S1). This low in the fossil record across Eurasia between 40,000 and 50,000 y percentage of endogenous DNA precludes sequencing of the ago. The genetic relationships between these early modern humans entire genome of this individual. Thus, we used DNA capture and present-day human populations have not been established. approaches to retrieve the mitochondrial (mt)DNA (6) and nu- We have extracted DNA from a 40,000-y-old anatomically modern clear DNA sequences from the Tianyuan individual. human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the mtDNA Capture and Sequencing. We used a protocol for targeted DNA sequences of the mitochondrial genome, the entire nonrepeti- DNA sequence retrieval that is particularly suited for mtDNA tive portion of chromosome 21 (∼30 Mbp), and over 3,000 poly- (6) to isolate mtDNA fragments.
    [Show full text]
  • The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans
    Report The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans Highlights Authors d Denisovan admixture into modern humans occurred after Sriram Sankararaman, Neanderthal admixture Swapan Mallick, Nick Patterson, David Reich d There is more Denisovan ancestry in South Asians than expected from current models Correspondence [email protected] (S.S.), d Denisovan ancestry has been subject to positive and [email protected] (D.R.) negative selection after admixture d Male infertility most likely occurred after modern human In Brief interbreeding with Denisovans Sankararaman et al. present a map of Denisovan and Neanderthal ancestry in 120 diverse populations and show that Denisovan admixture post-dated Neanderthal admixture. South Asians have more Denisovan ancestry than expected. There was selection both for and against archaic ancestry. Hybridization with Denisovans was probably associated with reduced male fertility. Sankararaman et al., 2016, Current Biology 26, 1–7 May 9, 2016 ª2016 Elsevier Ltd All rights reserved http://dx.doi.org/10.1016/j.cub.2016.03.037 Please cite this article in press as: Sankararaman et al., The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans, Current Biology (2016), http://dx.doi.org/10.1016/j.cub.2016.03.037 Current Biology Report The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans Sriram Sankararaman,1,2,* Swapan Mallick,3,4,5 Nick Patterson,4 and David Reich3,4,5,* 1Department of Computer Science, University
    [Show full text]
  • Qnas with David Reich
    QNAS QNAS QnAs with David Reich Beth Azar, Science Writer Harvard Medical School geneticist David Reich feels lucky to have found paleogenetics, a field that com- bines his love of history with his love of science. Reich plumbs data, collected by transcribing ancient DNA, to learn about human history, including migration pat- terns, social structures, health, and disease. Paleoge- netics has exploded in the last few years, with massive increases in the world’s dataset of ancient DNA. For his work in this field, Reich won the 2019 National Acad- emy of Sciences Award in Molecular Biology. PNAS recently spoke with Reich about his role in invigorating the field. PNAS: How did you become interested in analyzing ancient DNA as a means to understand human history? Reich: I’ve always been interested in human history. I began college majoring in sociology and history. I switched to physics in my third year and then did a fifth undergraduate year in biochemistry at Oxford. I found work in a [laboratory] with David Goldstein (now at Columbia University) who was studying human his- David Reich. Image courtesy of Howard Hughes Medical tory with genetic data. It was immediately interesting. I Institute/Bizuayehu Tesfaye. ended up staying for what became a PhD. But I en- tered the field before its time had come. We were PNAS: Which of your findings have been the most trapped by the small amount of data, and we were surprising? trapped by the fact that our samples were from the present. I left the field and went to medical school at Reich: I’ll list three.
    [Show full text]