Tinnitus: Ringing in the SYMPTOMS Ears
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Neurofibromatosis Type 2 (NF2)
International Journal of Molecular Sciences Review Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis Suha Bachir 1,† , Sanjit Shah 2,† , Scott Shapiro 3,†, Abigail Koehler 4, Abdelkader Mahammedi 5 , Ravi N. Samy 3, Mario Zuccarello 2, Elizabeth Schorry 1 and Soma Sengupta 4,* 1 Department of Genetics, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA; [email protected] (S.B.); [email protected] (E.S.) 2 Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] (S.S.); [email protected] (M.Z.) 3 Department of Otolaryngology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] (S.S.); [email protected] (R.N.S.) 4 Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] 5 Department of Radiology, University of Cincinnati, Cincinnati, OH 45267, USA; [email protected] * Correspondence: [email protected] † These authors contributed equally. Abstract: Patients diagnosed with neurofibromatosis type 2 (NF2) are extremely likely to develop meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary brain tumor; many NF2 patients suffer from multiple meningiomas. In NF2, patients have mutations in the NF2 gene, specifically with loss of function in a tumor-suppressor protein that has a number of synonymous names, including: Merlin, Neurofibromin 2, and schwannomin. Merlin is a 70 kDa protein that has 10 different isoforms. The Hippo Tumor Suppressor pathway is regulated upstream by Merlin. This pathway is critical in regulating cell proliferation and apoptosis, characteristics that are important for tumor progression. -
Definitions and Background
1 Definitions and Background Tinnitus is a surprisingly complex subject. Numer- ears.” And, in fact, the word “tinnitus” is derived ous books would be required to adequately cover the from the Latin word tinniere, which means “to current body of knowledge. The present handbook ring.” Patients report many different sounds—not focuses on describing procedures for providing just ringing—when describing the sound of their clinical services for tinnitus using the methodology tinnitus, as we discuss later in this chapter. of progressive tinnitus management (PTM). In this opening chapter we establish common ground with respect to terminology and contextual Transient Ear Noise information. Relevant definitions are provided, many of which are operational due to lack of consensus It seems that almost everyone experiences “tran- in the field. Additional background information sient ear noise,” which typically is described as a includes brief descriptions of epidemiologic data, sudden whistling sound accompanied by the per- patient data, and conditions related to reduced tol- ception of hearing loss (Kiang, Moxon, & Levine, erance (hypersensitivity) to sound. 1970). No systematic studies have been published to date describing the prevalence and properties of transient ear noise; thus, anything known about Basic Concepts and Terminology this phenomenon is anecdotal. The transient auditory event is unilateral and seems to occur completely at random without any- Tinnitus is the experience of perceiving sound that thing precipitating the sudden onset of symptoms. is not produced by a source outside of the body. The Often the ear feels blocked during the episode. The “phantom” auditory perception is generated some- symptoms generally dissipate within a period of where in the auditory pathways or in the head or about a minute. -
Recreational Noise-Induced Hearing Loss
Hearing loss due to recreational exposure to loud sounds A review World Health Organization Hearing loss due to recreational exposure to loud sounds A review World Health Organization Contributors: Etienne Krug, Maria Alarcos Cieza, Shelly Chadha, Laura Sminkey, Thais Morata, DeWet Swanepoel, Adrian Fuente, Warwick Williams, Joseph Cerquone, Ricardo Martinez, Gretchen Stevens, Margie Peden, Sowmya Rao, Paras Agarwal, Eighmey Zeeck, Anna Bladey, Malachi Arunda, Aileen Ncube. Graphics Credits: INIS Communications WHO Library Cataloguing-in-Publication Data Hearing loss due to recreational exposure to loud sounds: a review. 1.Hearing Loss, Noise-Induced. 2.Music. 3.Noise. 4.Recreation. 5.Noise. Transportation. 6.Adolescent. I.World Health Organization. ISBN 978 92 4 150851 3 (NLM classification: WV 270) © World Health Organization 2015 All rights reserved. Publications of the World Health Organization are available on the WHO website (http://www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for non- commercial distribution – should be addressed to WHO Press through the WHO website (http://www.who.int/about/licensing/copyright_form/en/index.html). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. -
Consultation Diagnoses and Procedures Billed Among Recent Graduates Practicing General Otolaryngology – Head & Neck Surger
Eskander et al. Journal of Otolaryngology - Head and Neck Surgery (2018) 47:47 https://doi.org/10.1186/s40463-018-0293-8 ORIGINALRESEARCHARTICLE Open Access Consultation diagnoses and procedures billed among recent graduates practicing general otolaryngology – head & neck surgery in Ontario, Canada Antoine Eskander1,2,3* , Paolo Campisi4, Ian J. Witterick5 and David D. Pothier6 Abstract Background: An analysis of the scope of practice of recent Otolaryngology – Head and Neck Surgery (OHNS) graduates working as general otolaryngologists has not been previously performed. As Canadian OHNS residency programs implement competency-based training strategies, this data may be used to align residency curricula with the clinical and surgical practice of recent graduates. Methods: Ontario billing data were used to identify the most common diagnostic and procedure codes used by general otolaryngologists issued a billing number between 2006 and 2012. The codes were categorized by OHNS subspecialty. Practitioners with a narrow range of procedure codes or a high rate of complex procedure codes, were deemed subspecialists and therefore excluded. Results: There were 108 recent graduates in a general practice identified. The most common diagnostic codes assigned to consultation billings were categorized as ‘otology’ (42%), ‘general otolaryngology’ (35%), ‘rhinology’ (17%) and ‘head and neck’ (4%). The most common procedure codes were categorized as ‘general otolaryngology’ (45%), ‘otology’ (23%), ‘head and neck’ (13%) and ‘rhinology’ (9%). The top 5 procedures were nasolaryngoscopy, ear microdebridement, myringotomy with insertion of ventilation tube, tonsillectomy, and turbinate reduction. Although otology encompassed a large proportion of procedures billed, tympanoplasty and mastoidectomy were surprisingly uncommon. Conclusion: This is the first study to analyze the nature of the clinical and surgical cases managed by recent OHNS graduates. -
BMC Ear, Nose and Throat Disorders Biomed Central
BMC Ear, Nose and Throat Disorders BioMed Central Case report Open Access Acute unilateral hearing loss as an unusual presentation of cholesteatoma Daniel Thio*1, Shahzada K Ahmed2 and Richard C Bickerton3 Address: 1Department of Otorhinolaryngology, South Warwickshire General Hospitals NHS Trust Warwick CV34 5BW UK, 2Department of Otorhinolaryngology, South Warwickshire General Hospitals NHS Trust Warwick CV34 5BW UK and 3Department of Otorhinolaryngology, South Warwickshire General Hospitals NHS Trust Warwick CV34 5BW UK Email: Daniel Thio* - [email protected]; Shahzada K Ahmed - [email protected]; Richard C Bickerton - [email protected] * Corresponding author Published: 18 September 2005 Received: 10 July 2005 Accepted: 18 September 2005 BMC Ear, Nose and Throat Disorders 2005, 5:9 doi:10.1186/1472-6815-5-9 This article is available from: http://www.biomedcentral.com/1472-6815/5/9 © 2005 Thio et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease with an acute hearing loss suffered immediately after prolonged use of a pneumatic drill. Case presentation: A 41 year old man with no previous history of ear problems presented with a sudden loss of hearing in his right ear immediately following the prolonged use of a pneumatic drill on concrete. -
Chronic Otitis Media: Histopathological Changes a Post Mortem Study on Temporal Bones
European Review for Medical and Pharmacological Sciences 1999; 3: 175-178 Chronic otitis media: histopathological changes A post mortem study on temporal bones F. SALVINELLI, M. TRIVELLI, F. GRECO, F.H. LINTHICUM JR* Institute of Otolaryngology, “Campus Bio-Medico” University - Rome (Italy) *Department of Histopathology, “House Ear Institute” - Los Angeles, CA (USA) Abstract. – The temporal bones of 4 Materials and Methods deceased individuals, with concomitant chronic otitis media are studied. The various histopathological changes in the middle ear We have studied the histopathological cleft are examined: suppuration, polyps, changes in temporal bones of 4 deceased in- granulation tissue. The possibilities of spon- dividuals, with concomitant chronic OM. taneous healing of a perforated TM and the These patients were donors and agreed indications of surgical treatment are dis- during their life to donate post mortem their cussed. temporal bones to the House Ear Institute as Key Words: a contribution to a better knowledge of tem- Temporal bone, Middle ear, Infection, Chronic in- poral bone diseases. flammation, Metaplasia, Complications. We have removed the temporal bones in our usual way9. Introduction Results Otitis media (OM) is an infection localized Clinical features in the middle ear: mastoid, middle ear cavity, The inflammation, while often indolent, eustachian tube. The classification of OM in- may at times give rise to serious complica- cludes: tions and even cause death. The hearing loss that is a constant concomitant also con- tributes to the immense socio-economic problem. Chronic OM sometimes, but not al- • OM with effusion1-3, without perforation ways, follows an attack of the acute disease. of the tympanic membrane (TM)4-6, due The major feature is discharge from the mid- to an increase of fluid in the middle ear dle ear. -
Cholesteatoma Handout
Cholesteatoma Handout A cholesteatoma is a skin growth that occurs in an abnormal location, usually in the middle ear space behind the eardrum. It often arises from repeated or chronic infection, which causes an in-growth of the skin of the eardrum. Cholesteatomas often take the form of a cyst or pouch that sheds layers of old skin that build up inside the ear. Over time, the cholesteatoma can increase in size and destroy the surrounding delicate bones of the middle ear. Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth. What are the symptoms? Initially, the ear may drain fluid, sometimes with a foul odor. As the cholesteatoma pouch or sac enlarges, it can cause a full feeling or pressure in the ear, along with hearing loss. Dizziness, or muscle weakness on one side of the face can also occur. Is it dangerous? Ear cholesteatomas can be dangerous and should never be ignored. Bone erosion can cause the infection to spread into the surrounding areas, including the inner ear and brain. If untreated, deafness, brain abscess, meningitis, and rarely death can occur. What treatment can be provided? Initial treatment may consist of a careful cleaning of the ear, antibiotics, and ear drops. Therapy aims to stop drainage in the ear by controlling the infection. The extent or growth characteristics of a cholesteatoma must then be evaluated. Cholesteatomas usually require surgical treatment to protect the patient from serious complications. Hearing and balance tests and CT scans of the ear may be necessary. These tests are performed to determine the hearing level remaining in the ear and the extent of destruction the cholesteatoma has caused. -
Inner Ear Infection (Otitis Interna) in Dogs
Hurricane Harvey Client Education Kit Inner Ear Infection (Otitis Interna) in Dogs My dog has just been diagnosed with an inner ear infection. What is this? Inflammation of the inner ear is called otitis interna, and it is most often caused by an infection. The infectious agent is most commonly bacterial, although yeast and fungus can also be implicated in an inner ear infection. If your dog has ear mites in the external ear canal, this can ultimately cause a problem in the inner ear and pose a greater risk for a bacterial infection. Similarly, inner ear infections may develop if disease exists in one ear canal or when a benign polyp is growing from the middle ear. A foreign object, such as grass seed, may also set the stage for bacterial infection in the inner ear. Are some dogs more susceptible to inner ear infection? Dogs with long, heavy ears seem to be predisposed to chronic ear infections that ultimately lead to otitis interna. Spaniel breeds, such as the Cocker spaniel, and hound breeds, such as the bloodhound and basset hound, are the most commonly affected breeds. Regardless of breed, any dog with a chronic ear infection that is difficult to control may develop otitis interna if the eardrum (tympanic membrane) is damaged as it allows bacteria to migrate down into the inner ear. "Dogs with long, heavy ears seem to bepredisposed to chronic ear infections that ultimately lead to otitis interna." Excessively vigorous cleaning of an infected external ear canal can sometimes cause otitis interna. Some ear cleansers are irritating to the middle and inner ear and can cause signs of otitis interna if the eardrum is damaged and allows some of the solution to penetrate too deeply. -
Bedside Neuro-Otological Examination and Interpretation of Commonly
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.2004.054478 on 24 November 2004. Downloaded from BEDSIDE NEURO-OTOLOGICAL EXAMINATION AND INTERPRETATION iv32 OF COMMONLY USED INVESTIGATIONS RDavies J Neurol Neurosurg Psychiatry 2004;75(Suppl IV):iv32–iv44. doi: 10.1136/jnnp.2004.054478 he assessment of the patient with a neuro-otological problem is not a complex task if approached in a logical manner. It is best addressed by taking a comprehensive history, by a Tphysical examination that is directed towards detecting abnormalities of eye movements and abnormalities of gait, and also towards identifying any associated otological or neurological problems. This examination needs to be mindful of the factors that can compromise the value of the signs elicited, and the range of investigative techniques available. The majority of patients that present with neuro-otological symptoms do not have a space occupying lesion and the over reliance on imaging techniques is likely to miss more common conditions, such as benign paroxysmal positional vertigo (BPPV), or the failure to compensate following an acute unilateral labyrinthine event. The role of the neuro-otologist is to identify the site of the lesion, gather information that may lead to an aetiological diagnosis, and from there, to formulate a management plan. c BACKGROUND Balance is maintained through the integration at the brainstem level of information from the vestibular end organs, and the visual and proprioceptive sensory modalities. This processing takes place in the vestibular nuclei, with modulating influences from higher centres including the cerebellum, the extrapyramidal system, the cerebral cortex, and the contiguous reticular formation (fig 1). -
153 Alcohol Intake, 47, 48 Aminoglycoside Antibiotics, 5
Index A Tinnitus Handicap Inventory (THI), 41–42 Tinnitus Problem Checklist, 44–45 Alcohol intake, 47, 48 Audiology, 24 Aminoglycoside antibiotics, 5 Individualized Support protocol, 77–79 Amitryptiline, 48 patient education, 26 Amphetamine abuse, 47 triage to, 37 Antidepressants, 48 Auditory imagery, 4 Anxiety, 47, 48, 69 Anxiolitics, 48 B Appendixes. See Forms Aspirin, 5, 48 Bipolar disorder, 47 Assessment. See also Audiologic Evaluation; Interdisciplinary Evaluation C mental health, 67–70 psychoacoustic, 72–73 Caffeine intake, 5, 48 Attention-deficit/hyperactivity disorder, 47 Case studies/patient examples Attention Scale, 61, 129–130 bilateral intermittent tinnitus, 32–33 Audiologic Evaluation bothersome tinnitus, 33 auditory function assessment, 42–43 CBT (cognitive-behavioral therapy), 81 and candidacy for Group Education, 40 hearing loss/tinnitus, 32 Ear-Level Instrument Assessment/Fitting Individualized Support, 81 Flowchart, 45, 113 phonophobia, 33 hearing aid evaluation, 45–47 (See also Hearing PTSD, 33 aids main entry) sensorineural hearing loss, 41 Hearing Aid Special Considerations, 46, 115 CBT (cognitive-behavioral therapy) Hearing Handicap Inventory, 42 case study, 81 and hyperacusis, 40, 41 clues for tinnitus management, 3 LDLs, 53 extended support option, 81–82 and mental health referral, 47 Group Education, 63–66 (See also Group Education objectives overview, 39, 99 main entry) otolaryngology exam need assessment, 43 Individualized Support, 80–81, 82 otoscopy, 42 and individualized support level, 30 overview, 27, 49 and patient education, 25, 31 patient example: sensorineural hearing loss, 41 in PTM foundational research, 17, 18–19 procedures overview, 39, 99 and STEM, 29, 55 pure-tone threshold evaluation, 42–43 telephone-based, 18 sleep disorder referral assessment, 47–48 CD/DVD: Managing Your Tinnitus, 151–152 somatosounds assessment, 43–44 Changing Thoughts and Feelings Worksheet, 64 suprathreshold audiometric testing, 43 Chemotherapy, 5, 48 THI (Tinnitus Handicap Inventory), 41–42, 105– Chronic tinnitus, 2. -
List of Phobias: Beaten by a Rod Or Instrument of Punishment, Or of # Being Severely Criticized — Rhabdophobia
Beards — Pogonophobia. List of Phobias: Beaten by a rod or instrument of punishment, or of # being severely criticized — Rhabdophobia. Beautiful women — Caligynephobia. 13, number — Triskadekaphobia. Beds or going to bed — Clinophobia. 8, number — Octophobia. Bees — Apiphobia or Melissophobia. Bicycles — Cyclophobia. A Birds — Ornithophobia. Abuse, sexual — Contreltophobia. Black — Melanophobia. Accidents — Dystychiphobia. Blindness in a visual field — Scotomaphobia. Air — Anemophobia. Blood — Hemophobia, Hemaphobia or Air swallowing — Aerophobia. Hematophobia. Airborne noxious substances — Aerophobia. Blushing or the color red — Erythrophobia, Airsickness — Aeronausiphobia. Erytophobia or Ereuthophobia. Alcohol — Methyphobia or Potophobia. Body odors — Osmophobia or Osphresiophobia. Alone, being — Autophobia or Monophobia. Body, things to the left side of the body — Alone, being or solitude — Isolophobia. Levophobia. Amnesia — Amnesiphobia. Body, things to the right side of the body — Anger — Angrophobia or Cholerophobia. Dextrophobia. Angina — Anginophobia. Bogeyman or bogies — Bogyphobia. Animals — Zoophobia. Bolsheviks — Bolshephobia. Animals, skins of or fur — Doraphobia. Books — Bibliophobia. Animals, wild — Agrizoophobia. Bound or tied up — Merinthophobia. Ants — Myrmecophobia. Bowel movements, painful — Defecaloesiophobia. Anything new — Neophobia. Brain disease — Meningitophobia. Asymmetrical things — Asymmetriphobia Bridges or of crossing them — Gephyrophobia. Atomic Explosions — Atomosophobia. Buildings, being close to high -
Can Other People Hear the Noise in My Ears? Not Usually, but Sometimes They Are Able to Hear a (Ertant Type Oftinnitus
Not at all. Tinnitus is the name for these head noises, and they are very common. Nearly 36 million Americans suffer from this discomfort. Tinnitus mav come and go, or you may be aware of a continuous sound. It can vary in pitch from a low roar to a high squeal or whine, and you may hear it in one or both ears. When the ringing is constant, It can be annoying and distracting. More than seven million people are afflicted so severely that they cannot lead normal lives. Can other people hear the noise in my ears? Not usually, but sometimes they are able to hear a (ertant type oftinnitus. This is called objective tinnitus, and it is caused either by abnormalities in blood vessels around the outside of the ear or by muscle spasms, which may sound like clicks or crackling illside the middle ear. There are many causes for subjective tinnitus, the nOlSC only you can hear. Some causes are not serious (a small plug of wax in the ear canal might cause temporary tinnitus). Tinnitus can also be a symptom of more serious middle ear problems such as infection, a hole in the eardrum, an accumulation of fluid, or stiffening (otosclerosis) of the middle ear bones. Tinnitus may also be caused by allergy, high or 10\V blood pressure (blood circulation problems), OUTER EAR MIDDLE EAR INNER EAR \ a tumor, diabetes, thyroid problems, injury to the head or neck, and a variety of other causes including medications such as anti-inflammatories, antibiotics, sedatives/antidepressants, and aspirin.