Sensitivity to Changes During Antidepressant Treatment: a Comparison of Unidimensional

Sensitivity to changes during antidepressant treatment: A comparison of unidimensional subscales of the Inventory of Depressive Symptomatology (IDS-C) and the Hamilton Depression Rating Scale (HAMD) in patients with mild major, minor or subsyndromal depression

Isabella Helmreich1§, Stefanie Wagner1, Roland Mergl2, Antje-Kathrin Allgaier3, Martin Hautzinger4, Verena Henkel5, Ulrich Hegerl2#, André Tadić1#

1Department of Psychiatry and Psychotherapy University Medical Centre Mainz, Germany; 2Department of Psychiatry, University of Leipzig, Germany; 3Department of Child and Adolescent Psychiatry, Ludwig- Maximilians-University Munich, Germany; 4Institute of Psychology, Department of Clinical and Developmental Psychology, University of Tuebingen, Germany; 5Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany.

#These authors contributed equally to this work.

§Corresponding author: Isabella Helmreich; Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, D-55131 Mainz, Germany, phone: +49 6131 17- 2989, fax: +49 6131 17-6490; e-mail: [email protected] Online Resource 1 Change agreement (Kappa) for the different scales for the different depression severity

levels (according HAMD17 cut-off values)

Bech6 Evans6 MP6 Toronto7 Santen7 Gibbons8 ADAM2 Total (n=1143)

QIDS-C16 0.40 0.41 0.41 0.43 0.42 0.44 0.25

Bech6 - 0.72 0.73 0.70 0.88 0.56 0.47

Evans6 - - 0.61 0.88 0.69 0.66 0.43

MP6 - - - 0.60 0.69 0.65 0.48

Toronto7 - - - - 0.74 0.71 0.43

Santen7 - - - - - 0.61 0.46

Gibbons8 ------0.45 Subthreshold (n=487)

QIDS-C16 0.38 0.40 0.41 0.42 0.40 0.43 0.22

Bech6 - 0.75 0.78 0.74 0.93 0.59 0.50

Evans6 - - 0.63 0.94 0.73 0.70 0.43

MP6 - - - 0.64 0.76 0.70 0.52

Toronto7 - - - - 0.75 0.71 0.44

Santen7 - - - - - 0.61 0.48

Gibbons8 ------0.47 Mild (n=224)

QIDS-C16 0.36 0.38 0.39 0.37 0.35 0.46 0.27

Bech6 - 0.70 0.67 0.68 0.87 0.49 0.46

Evans6 - - 0.59 0.86 0.63 0.60 0.40

MP6 - - - 0.60 0.67 0.63 0.48

Toronto7 - - - - 0.73 0.69 0.41

Santen7 - - - - - 0.56 0.46

Gibbons8 ------0.41 Moderate (n=432)

QIDS-C16 0.42 0.40 0.38 0.46 0.45 0.43 0.25

Bech6 - 0.67 0.69 0.63 0.80 0.53 0.40

Evans6 - - 0.58 0.81 0.64 0.64 0.41

MP6 - - - 0.52 0.59 0.57 0.40

Toronto7 - - - - 0.72 0.72 0.41

Santen7 - - - - - 0.60 0.42

Gibbons8 ------0.41

HAMD17 17-item version of the Hamilton Depression Rating Scale, QIDS-C16 Quick Inventory of Depressive

Symptomatology-Clinician Rating, Bech6 Bech melancholia scale, Evans6 Evans and colleagues scale, MP6 Maier-

Phillipp severity subscale, Toronto7 Toronto scale, Santen7 Santen Subscales 1, Gibbons8 Gibbons’ global depression severity, ADAM2 Absence of Depressive and Anxious Mood scale Online Resource 2 Treatment scale score comparison regarding mean ± standard deviation (SD)

Baseline Week 2 Week 4 Week 6 Week 8 Week 10 Sertraline (n=113) (n=103) (n=102) (n=94) (n=87) (n=95)

QIDS-C16 12.10 ± 3.56 10.04 ± 3.77 9.38 ± 4.55 7.72 ± 4.82 7.32 ± 4.35 7.20 ± 5.22

Bech6 9.17 ± 2.44 7.30 ± 3.02 6.33 ± 3.59 5.36 ± 3.76 4.98 ± 3.49 4.66 ± 4.25

Evans6 10.27 ± 2.67 8.35 ± 3.37 7.34 ± 3.93 6.32 ± 4.26 5.91 ± 3.79 5.64 ± 4.61

MP6 8.87 ± 2.40 7.17 ± 2.90 6.25 ± 3.53 5.20 ± 3.58 4.83 ± 3.30 4.62 ± 3.95

Toronto7 11.01 ± 2.99 8.86 ± 3.73 7.81 ± 4.38 6.68 ± 4.70 6.22 ± 4.10 5.95 ± 4.97

Santen7 9.91 ± 2.76 7.82 ± 3.39 6.80 ± 4.05 5.72 ± 4.23 5.29 ± 3.84 4.97 ± 4.61

Gibbons8 11.69 ± 3.13 9.72 ± 3.94 8.56 ± 4.64 7.32 ± 4.94 6.89 ± 4.33 6.65 ± 5.08

ADAM2 3.89 ± 1.20 3.03 ± 1.43 2.56 ± 1.72 2.18 ± 1.59 2.02 ± 1.49 1.92 ± 1.78 Placebo (n=70) (n=67) (n=64) (n=61) (n=54) (n=61)

QIDS-C16 12.11 ± 3.36 10.58 ± 4.55 9.66 ± 4.32 9.72 ± 4.44 8.63 ± 4.61 8.59 ± 5.16

Bech6 9.04 ± 2.35 7.87 ± 3.51 7.23 ± 3.38 6.98 ± 3.47 6.11 ± 3.60 6.30 ± 3.78

Evans6 9.96 ± 2.66 8.75 ± 3.83 8.13 ± 3.86 8.05 ± 3.92 7.06 ± 3.94 7.25 ± 4.10

MP6 8.50 ± 1.98 7.22 ± 3.14 6.80 ± 3.24 6.67 ± 3.43 5.80 ± 3.51 5.85 ± 3.54

Toronto7 10.66 ± 2.91 9.33 ± 4.14 8.59 ± 4.14 8.54 ± 4.26 7.48 ± 4.32 7.72 ± 4.57

Santen7 9.74 ± 2.52 8.45 ± 3.82 7.70 ± 3.67 7.48 ± 3.81 6.54 ± 3.97 6.77 ± 4.26

Gibbons8 11.09 ± 2.76 9.55 ± 3.99 9.13 ± 4.24 9.10 ± 4.57 7.98 ± 4.58 8.07 ± 4.73

ADAM2 3.69 ± 1.11 3.34 ± 1.52 3.17 ± 1.57 2.97 ± 1.81 2.65 ± 1.68 2.67 ± 1.82 CBT (n=66) (n=59) (n=62) (n=60) (n=49) (n=58)

QIDS-C16 11.65 ± 3.41 10.75 ± 4.07 10.19 ± 4.16 9.13 ± 4.45 8.33 ± 4.73 7.40 ± 4.63

Bech6 8.70 ± 2.41 7.46 ± 2.97 7.45 ± 3.28 6.62 ± 3.08 6.47 ± 3.36 5.59 ± 3.59

Evans6 9.92 ± 2.61 8.63 ± 3.32 8.68 ± 3.63 8.02 ± 3.53 7.63 ± 3.95 6.38 ± 3.99

MP6 8.42 ± 2.21 7.25 ± 2.72 7.29 ± 2.91 6.35 ± 2.92 6.35 ± 3.13 5.36 ± 3.34

Toronto7 10.67 ± 2.98 9.19 ± 3.67 9.19 ± 3.92 8.53 ± 3.94 7.96 ± 4.27 6.66 ± 4.32

Santen7 9.44 ± 2.74 8.02 ± 3.28 7.97 ± 3.55 7.13 ± 3.52 6.80 ± 3.69 5.86 ± 3.90

Gibbons8 11.39 ± 2.99 9.78 ± 3.65 9.89 ± 3.59 9.13 ± 3.96 8.63 ± 4.22 7.12 ± 4.33

ADAM2 3.89 ± 1.15 3.47 ± 1.46 3.26 ± 1.43 3.20 ± 1.54 3.20 ± 1.51 2.47 ± 1.76 GSG (n=38) (n=31) (n=30) (n=30) (n=23) (n=29)

QIDS-C16 10.63 ± 3.45 9.45 ± 2.91 8.30 ± 3.86 9.27 ± 4.03 9.70 ± 2.80 9.72 ± 4.67

Bech6 8.55 ± 2.61 8.03 ± 2.47 7.23 ± 2.58 7.97 ± 3.00 7.87 ± 2.46 7.21 ± 3.35

Evans6 9.61 ± 2.54 9.29 ± 2.47 8.47 ± 2.76 8.97 ± 3.10 8.96 ± 3.01 8.34 ± 3.57

MP6 8.16 ± 2.69 7.68 ± 2.29 6.83 ± 2.56 7.50 ± 3.05 7.30 ± 2.46 7.00 ± 3.17

Toronto7 10.13 ± 2.91 9.68 ± 2.73 8.87 ± 3.01 9.40 ± 3.39 9.35 ± 3.13 8.79 ± 3.95

Santen7 9.08 ± 2.95 8.42 ± 2.75 7.63 ± 2.83 8.40 ± 3.27 8.26 ± 2.56 7.66 ± 3.75

Gibbons8 10.68 ± 3.33 10.19 ± 2.71 9.30 ± 3.34 9.80 ± 3.69 9.74 ± 3.29 9.62 ± 4.09

ADAM2 3.79 ± 1.12 3.65 ± 1.23 3.03 ± 1.33 3.33 ± 1.30 3.17 ± 1.27 3.10 ± 1.52

QIDS-C16 Quick Inventory of Depressive Symptomatology-Clinician Rating, Bech6 Bech melancholia scale, Evans6

Evans and colleagues scale, MP6 Maier-Phillipp severity subscale, Toronto7 Toronto scale, Santen7 Santen

Subscales 1, Gibbons8 Gibbons’ global depression severity, ADAM2 Absence of Depressive and Anxious Mood scale, CBT Cognitive-behavioural group therapy, GSG Guided self-help groups