Supplementary information

Essentiality of Succinate Dehydrogenase in Mycobacterium smegmatis and its Role in the Generation of the Membrane Potential under Hypoxia

Ildiko Pecsi1, Kiel Hards1, Nandula Ekanayaka1, Michael Berney1,2, Travis Hartman2, William R. Jacobs Jr.2, and Gregory M. Cook1,3*

1 University of Otago, Department of Microbiology and Immunology, Dunedin 9054, New Zealand

2 Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx 10461, New York, USA

3 Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1042, New Zealand

I.P. and K.H. contributed equally to this work

To whom correspondence should be addressed: Gregory M. Cook Department of Microbiology and Immunology, University of Otago, Dunedin 9054 Email: [email protected], Tel: +64(0)3479772; Fax: +64(0)34798540

Key words: succinate dehydrogenase, membrane potential, hypoxia, fumarate reductase, essentiality

Running title: Essentiality of succinate dehydrogenase in mycobacteria

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