David Granville

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Name / Full Titles / Contact Information: David Granville, Ph.D. Assistant Professor/Canada Research Chair U.B.C. McDonald Research Laboratory / The iCAPTURE Centre Room 375, Burrard West St. Paul’s Hospital, Burrard Building, 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6 Canada Phone: (604) 806-9267 Fax: (604) 806-9274 Email: [email protected] URL: http://www.chairs.gc.ca/english/profile/viewprofile.cfm?ID=210

Bio/ Short Paragraph:

In his brief career, Dr. David Granville has completed extensive work on programmed cell death and its role in the treatment and pathogenesis of cancer and cardiovascular disease. His research program is aimed at studying the role of cell death in common vascular disorders such as atherosclerosis, restenosis and cardiac transplant vascular disease. His current research activities are focussed on the biochemical and cellular mechanisms of cardiovascular injury:  Alterations in mitochondrial protein translation, electron transport activity and superoxide production associated with myocardial ischemia/reperfusion injury  Regulation of mitochondrial protein synthesis during cardiac preconditioning and ischemia/reperfusion injury  Biochemical regulation of endothelial and smooth muscle apoptosis  Role of apoptosis and its contribution to vascular permeability in the context of transplant vascular disease Past research activities:  Cellular mechanisms involved in photodynamic therapy (PDT)-induced apoptosis  Viral and cellular mechanisms involved in coxsackievirus-induced cytopathic effect  Kinase activation and tyrosine phosphorylation events in response to PDT

Education / Training:

University or Institution Degree Subject Area Dates Simon Fraser University B.Sc. Biological Sciences 1989-1994 University of British Columbia Ph.D. Pathology and 1997- 2001 Laboratory Medicine

Recent Publications: (****all references are linked to PubMed)

Granville, D.J., McManus, B.M., and Hunt, D.W. (2001). Photodynamic Therapy: Shedding light on the biochemical pathways regulating porphyrin-mediated cell death. Histol. Histopathol. 16:309-317. (Invited review)

Miller, L., Granville, D.J., Narula, J. and McManus, B.M. (2001) Apoptosis in Cardiac Transplant Rejection. Cardiol. Clin.19(1):141-154.

Hunt, D.W., Jiang, H., Salmon, R.A., Granville, D.J., North, J.R. and Richter, A.M. (2001) Action of the photosensitizer QLT0074 upon human T lymphocytes in vitro. SPIE. 4248: 114- 131. Matroule, JY, Carthy, C.M., Granville, D.J., Hunt, D.W., and Piette, J. (2001) Mechanism of colon cancer cell apoptosis by pyropheneophorbide-a methylester photosensitization. Oncogene 20: 4070-4084.

Granville, D.J., Cassidy, B.A., Ruehlmann, D., Choy, J., Brenner, C., Kroemer, G., Margaron, P., van Breemen, C., Hunt, D.W. and McManus, B.M. (2001) Mitochondrial Release of Apoptosis Inducing Factor (AIF) and Cytochrome c During Smooth Muscle Cell Apoptosis. Am. J. Pathol. 159:305-311.

Choy, J., Granville, D.J., Hunt, D.W. and McManus, B.M. (2001) Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J. Mol. Cell Cardiol. 9: 1673-1690.

Granville, D.J., Jiang, H., McManus, B.M. and Hunt, D.W. (2001) Fas ligand and TRAIL augment the effect of photodynamic therapy on the induction of apoptosis in Jurkat cells. Int. Immunopharmacol. 1: 1831-1840.

Granville, D.J., Ruehlmann, D., Choy, J., Cassidy, B.A., Hunt, D.W., van Breemen, C. and McManus, B.M. (2001) Bcl-2 increases emptying of endoplasmic reticulum Ca2+ stores during photodynamic therapy-induced apoptosis. Cell Calcium 30(5): 343-350.

Loucks, E.B., Godin, D.V., Walley, K.R., McManus, B.M., Rahimian, R., Granville, D.J., Hong, J.M., Aktary, F.M., Qayumi, A.K.: Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. Can J Cardiol (in press)