DNA: a Summary of Important Historical Discoveries

DNA: A Summary of Important Historical Discoveries Bio 12 Allen

Outcomes addressed: (315-1) summarize the main scientific discoveries that led to the modern concept of the gene (114-2) explain the role of evidence, theories, and paradigms in the development of this scientific knowledge (115-3) explain how a major scientific milestone revolutionized thinking in the scientific communities

Using your notes and text, complete the cart below Scientist(s) year brief summary of experiment (if details are Conclusions made from experiment available to you)

Friedrich 1869 Miescher

Walter Sutton 1902

Thomas Hunt 1910 Morgan

Joachim 1930 Hammerling

Frederick 1931 • Griffith

Oswald Avery 1944 & associates

Hershey & 1952 • Chase

DNA: A Summary of Important Historical Discoveries Bio 12 Allen Using your notes and text, complete the cart below

Scientist(s) year brief summary of experiment (if details are Conclusions made from experiment available to you)

Friedrich 1869 Isolated the nuclei from pus cells nuclein  rich in phosphorus, contained no Miescher • Discovered a chemical that didn`t act sulfur (so it wasn’t protein) like protein. He named it “nuclein”

Walter Sutton 1902 observed that chromosomes obey Mendel's rules of inheritance -Suggested that “genes” are located on chromosomes. Noticed that “genes” are inherited in the same fashion as chromosomes Thomas Hunt 1910 Stated that each “gene” had a locus on a Morgan particular chromosome

Joachim 1930 Studied Acetabularia. Cut off foot/stalk hereditary information is localized to nuclei Hammerling

Frederick 1931 • Injected mice with smooth virulent and Coined the term, ‘transforming principle”. Griffith rough avirulent strains of bacteria.

Oswald Avery 1944 • experiment led Avery to design his own Results suggested that DNA was the & associates experiments to identify the “transforming transforming agent agent.” Enzymes that degrade proteins and RNA did not prevent transformation. Enzymes that digest DNA did prevent transformation. Hershey & 1952 • grew two batches of phages in DNA is the genetic information. NOT protein Chase radioactive sulfur/phosphorous