Subject Index

absorption enhancer 166 bile acid Ill; 160 (see also permeability enhancer) binary complexes 74 acetaminophen 61, 128, 138, 143,214 bioavailability 105, 108, 145, 153, 156, 166, (see also paracetamol) 169,173,174,177,181-183 acetic acid 75 biopharmaceutics 105 acetohexaminde 119 biphenyl 73 acetone 74, 85 biphenyl acetate 169, 175, 176,208 acetylsalicylic acid 65, 66, 95,154,200 biphenyl acetic acid 169, 121 acid hydrolysis 12 biphenylacetic ester 200 adenosinediphosphate 123 bisabolol 66 adhesive tapes 187,211,212 bitter taste 127 adiabatic compressibility 6 (see also taste, unpleasant) aerosols 188 branched CDs 3, 44,157 alfaxalone 162 brexin 218 Allidex 218 bromo-benzene 48, 73 amantadine 54 buccal absorption 155 amino acids 134 buserelin acetate 183, 193,203 amorphous state 146 butylparaben 171 Amphotericin B 13,61,66 amylase 33 caboxymethylethyl-~CO 192 androsterone 42 caffeine 128 anethol129 camomile oil 89, 103, 130,213 aniline 53, 73, 74 camphor 129, 174, 186,209,213 anthracene 73 canrenone 68, 108 aroma 129 caproic acid 73 ascaridol 66, 76 capsules 155, 197,214 ascorbic acid 128,78 caraway oil 95 aspartame 128, 155 carbamazepine 119, 161 association constant 56 carbenicillin 66 atorpine 65 carbon dioxide 85 azulenol213 carmufor 66, 79, 114, 175, 192 Carthamus tinctorius 133 bandages 187,212 carvone68 barbiturate 34,117,124 catalytic effects 152 bead polymers 188 cataplasms 187,212 beclomethasone 119, 168 COPS 22, 41 bencyclane 128 COPS! 22,41 benexate 117 cephaeline 66, 70,157,202 benoxaprofen 69,123 cetylpyridinium bromide 188 benzaldehyde 117, 133, 155,200 cetylpyridinium-chloride 192 benzalkonium chloride 147, 160, 181 CGT-enzyme 14 benzene 48, 73 chamazulene 130 benzoate 74 chaulmoogric acid 76 benzocaine 65 chemically modified CDs 19 benzoic acid 48, 49, 54 chewing gum 132, 186 betamethason 66, 167, 168,203 chlorambucil 163 220 SUBJECT INDEX chloramphenicol 138, 145 199,202,207 chlorbutanol 174 dibucaine 205 chlorine 85 diclofenac 181 chloro-benzene 48, 73 diethyl ether 73,84 chlorophenol 73 differential scanning calorimetry 88 chlorpromazine 66, 70, 122, 124 diffusion 10,61,80 cholecalciferol 65, 78, 117 diffusion constaat 6 cholesterol 20, 41, 113, 122, 123, 124, 160 digitoxin 23, 24, 65, 66, 198 Cicladol218 digoxin 198 cimetidine 65 dihydroxypropyl derivatives 20 cinnarizine 66,110 diltiazem 66, 189, 190, 192,214 circular dichroism 58 DIMEB 20, 22, 25, 41, 43,70, 165 citral130 Dimethyl-aniline 73 c1obethasone 181,211 dimethylformamide 87 clofibrate 69, 128, 133, 153, 198 diphenhydramine 205 clumping tendency 88, 97 diphenylamine 13 cocrystallization 97 dipiridamole 22,28,29, 117, 123 competitive reactions 1l0, 113, 147, 167, 173, disintegration 135, 141, 144, 153, 154 177 disopyramide 128 complex preparation 83 dispersed amount method 99 compression of tablets 139 dissociation constant 52, 60, 146 congo red 57 dissolution properties 99 contact angle 99 dissolution rate 105, 139, 141, 145, 153, 154 corticosteroid 204 distribution of drugs 113 cortisol 42 doxorubicin 66 cortisone 135 drying 89 cosmetic emulsion 207 drying loss 5 cosmetics 159 creosote 128 effervescent tablets 155 critical micelle concentration 60 elimination of drugs 113 crosslinking agents 29 emetine 70,157,202 crown ether 73 emulsions 159,206,207 crushing strength 135, 136, 139 epichlorhydrin 29 crystal forms 6, 7 ergocalciferol 135, 137,202 crystal growth 158, 167, 173 essential oils 68,85,89, 129, 133, 173,208 crystal hydrage 74 estradiol 155, 163, 171, 172, 180, 183, 184, crystal lattice 5 185,208 crystallinity 135 ethambutol 65 crystal structure 74, 105, 139 ethano175,84,85,87 Crystal violet 57 ethiazide 66 crystal water 6 ethyl biphenyl acetate 175,208 CfG-ase enzyme 217 ethyl bromide 73 cyclodextrin hydrate 7 ethyl-fluocinolone acetonide 187 iodoaniline 74 fluorescence 58 iodobenzene 48, 73 fluoro-benzene 48, 73 iodobenzoic acids 48 fluorometholone 181, 210 iomeglamic acid 154, 198 fluorouracil 79, 121 ipecac syrup 70, 157 flurbiprofen 24, 109, 113, 121, 164, 178, 180, ipriflavone 10 1, 109 181 IR spectroscopy 94 foam 206 irradiation 69, 71,123 fragrances 94 irritation 40, 42, 43, 120, 124, 164 free radical 70 isoleucine III friability 144 isomorphism 96 furosemide 66, 116, 141, 144, 145, 155 isosorbide dinitrate 66, 102, 187, 190, 191, 212 garlic oil 128, 133, 155,218 isosorbide-5-mononitrate 132 gels 105, 106, 167, 168 granulation 138, 140, 152 kneading method 86, 97 grinding 135, 154 krypton 74,85 griseofulvin 22, 28, 135, 145 growth hormone 163 lavender 103 guaiazulene 66, 130 lemon oil 69 leucine 111 haemolysis 20, 41, 43,69,120,122,123,164 libexine 128 haemolytic 42 lidocain 28,181, 191, 203, 210 hardness 144 linoleic acid 76 heparin 191 liposomes 159 hexamethylmelamine 163 liquid preparations 157 hexobarbital 114 liquid substances 133 hormones 182 lomustine 163 HP13CD 21, 22, 41, 42,136,147,165 lymphotropic transport 115 hydrocortisone 25, 28, 29, 87, 100, 102, 143, lysozyme 181 205 hydrolysis 37, 64 malachite green 57 hydroxyalkylated CDs 21 marcaine (bupivacaine) 192 hydroxybenzoic acid 60 marjoram 103 hydroxypropyl-CDs 27 mass spectrometry 88 hygroscopicity 97 mechanochemical activation 87 medroxyprogesterone acetate 199 ibuprofen 22,28, 100, 109, 145, 177, 179,207 mefenamic acid 190, 214 imipramine 123 mefenorex 65, 67 implants 159 melphalan 65, 66, 67 inclusion catalysis 63 melting point 8, 146 incompatibility 134, 166 membrane interactions 112, 120 indicators 57 menadione 59, 72, 78,105,117,134 indomethacin 22, 23, 28, 61, 66, 87, 101, 119, menatetrenone 197 121, 135, 138, 145, 154, 157, 171, 175, menthol 86, 90, 92, 129, 132, 186,209,213 181,190,197,207,211,214 mephalan 163 infusions 159 methanol 74, 75, 85 inhalants 186 methotrexate 163 injections 159 methyl-ethyl ketone 14,74 inorganic compounds 146 methyl orange 57, 72, 144 insulin 163, 164, 184,208 methyl-p-hydroxybenzoate 145 interactions, avoidance of 134 methylaniline 73 222 SUBJECT INDEX methylated CDs 25 penetration enhancer 171 methylene blue 57, 61 penicillin 187, 192 methylpentinol 96 pentobarbital 114 methyl salicylate 187 peppermint oil 132, 213,186 methyltestosterone 28 peptides 183 metoclopramid 191 percutaneous drug absorption 169, 171 metronidazole 66, 79, 158 periodate oxidation II miconazol167, 168, 169,205 peritoneal solution 165 micro-enemas III permeability enhancer 171 microcapsules 187 (see also absorption enhancer) Mitomycin C 66 permeability of membrane 112 mixing 135 pessaries 179 mixture 111, 113, 153, 161, 175, 179 pharmacokinetic parameters 109 mono palmi tin 89 pharmacokinetics 105, 114, 163, 164 morphine 119, 174 pharmacological effects 115 mydeton 66, 133 phase transfer 63 phenobarbital 105, 114, 117, 134, 139, 145, naphthalene 58, 73 175,199 naphthol 14, 74 phenol 53, 60, 147 naphthylamine 73 phenolphthalein 57 naproxen 112,113,121, 179, 191 phenylalanine 32, 110 nasal delivery 183,208 phenylbutazone 121 natural flavours 94 phenytoin 114,158,161,178 neohesperidin dihydrocha1cone 128 phospholipids 113, 159 nephrosis 38 photoallergic responses 123 neutral red 57 photodegradation 68 nicotinic acid 60 photolysis 68 nifedipine 101, 145 photooxidation 69 nitroglycerin 66, 96, 132, 133, 154, 187, 189, pinacyanol chloride 61 201,212,214 pinaverium bromide 128 nitrophenol49, 60, 61 piretanide 191, 215 nitrophenolate 74 piroxicam 109, 117, 119, 121, 138,217,218 nitrosamines 65 pirprofen 128 nitrosation 65 plant extracts 94 nitroxymethyl-6-chloropyridine 169, 187,212 polymers of cyclodextrins 114, 140, 155, 172, Nocloprost 133, 153 186,187,205,206 nonylic acid 187 polymorphic transition 89 nose drops 208, 210 polypeptides 163 nystatin 109, 181 powders 188,213 prednisolone 23, 24, 139, 145, 153, 164, 169, Oenanthera aquatica 134 177,178,199,204,207,211 odours 127 pregnadiene-dione 206, 210, 211 ointments 166, 203-205 preservati ve 152 ophthalmic preparations 180,210 prochlorperazine 124 orange oil 68, 130, 133 progesterone 24, 25, 138, 155, 184,210 ovine growth hormone 163 propanol 74, 75,85 oxidation 69 proscillaridin 64, 66 oxygen uptake 103, 130 prostacyclin 66 prostaglandin 65, 66, 77, 84, 133, 153, 160, papaverine 134 164, 174, 187, 189, 197, 201, 203, 211, paracetamol 89, 190,200 213 (see also acetaminophen) Prostarmon ® 77, 218 parenteral preparations 159 Prostavasin ® 77, 218 partial molar volumes 6 protein 146, 163 particle size 105, 135 protriptyline 69, 123 partition coefficient 63,166,171 pyrenesulphonate 72 SUBJECT INDEX 223 pyrolysis 88 surfactants 161, 166 pyrolytic gas chromatography 93 suspensions 157, 202 sustained release formulations 188,212-214 quinine 128 sweetness 127 syrups 201 RAMEB 20, 22, 25 rectal drug absorption 111 tablet hardness 135 rectal preparations 172, 184, 207 tablets 139, 154, 198,213,215 Rhodamine B 61 T AS technique 91 relative permittivity 6 taste, unpleasant 127, 128, 158 retinoic acid 70 Tegra 218 retinoids 124 teniposide 163 rotating disc method 99 ternary complex 72, 73, 84 rubusoside 127 terpenoids 85 terpinene 69 saccharin 128 testosterone 24, 42, 72, 155 salbutamol 191 tetrahydro-cannibanol 66 salicylic acid 57, 61,105,132,145 thalidomid 66 semustine 163 theophyllin 190, 191,214 side effects 120 thermal analysis 88 sieve analysis 97 thermal decomposition 90 slurry method 85, 97 thermal degradation 92 smell, unpleasant 127 thermal evolution analysis 88 solid preparations 152 thermoanalytical properties 8 solubility 6, 9, 105 thermoderivatography 88 solubility isotherm 54 thermofractography 93 solubilization 160, 181 thiamutiline 202 solutions 157 thin-layer chromatography 92, 103 spironolactone 68, 108, 116, 139, 143, 145, thiopental 114, 163 155, 199 thymol 213 spray drying 136 thymoxamine 66 stability constant 52, 56, 106, 113, 117, 121, tiamulin 122, 164 146 tixocortol167, 168,204 stabilizing effects 76 tocopherol acetate 187 sterilization 161, 162, 165 a-tocopheryl nicotinate 108 steroid 25, 154 tolbutamide 115 stevioside 127 tolnaftate 22, 28, 29, 172, 173, 200 stoichiometry 146 toluene 14 streptokinase 163 toluidine blue 57 subcutaneous administration 164 transdermal administration 169 sublimation 132, 145 transdermal tape 187 sublingual tablets 156 triamcinolone acetonide 29,102,187 substitution degree 27 TRIMEB 22, 25,41 SUDIMEB41 sulfacetamide 170 urokinase 163 sulfamethoxazole 179 sulfanilic acid 171 vacuum sublimation 72, 86, 88, 91 sulfoalkylethers 44 vaginal preparations 172 SUMEB22 valerie acid 75 supersaturation 161 Validol 101 "super solubility" 101 vanillyl aldehyde 187 suppositories 172-174, 177,207,208 viscosity 10 surface active agents 105 vitamin A 78, 201 surface activity 28, 60 vitamin A acetate 66 surfactant 115, 162 vitamin D3 49, 57, 66, 78,90 surfactant activity 26 vitamin E 70 224 SUBJECT INDEX vitamin K3 57, 66, 78, 117, 197 X-ray powder diffraction 6, 96 volatile oils 87 xenon 85 volatility 70, 88 Xund 218 warfarin 87, 138, 143, 154 zidovudine 23 wettability 98 zipeproJ 128 water content 135 Inclusion Science ADVANCES IN INCLUSION SCIENCE

1. J. Szejtli (ed.): Proceedings of the First International Symposium on Cyclodextrins. Budapest, Hungary (1981).1982 ISBN 90-277-1433-9 2. Alex I. Kllivlirllinen: Solvent-Dependent Flexibility of Proteins and Principles of Their Function. 1985 ISBN 90-277-1534-3 3. J. L. Atwood, J. E. D. Davies and T. Osa (eds.): Clathrate Compounds, Molecular Inclusion Phenomena, and Cyclodextrins. Proceedings of the 3rd International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the 2nd International Symposium on Cyclodextrins, Tokyo, Japan (1984). 1985 ISBN 90-277-201O-X 4. J. L. Atwood and J. E. D. Davies (eds.): Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts. Proceedings of the 4th International Symposium on Inclusion Phenomena and the 3rd International Symposium on Cyclodextrins, Lancaster, U.K. (1986).1987 ISBN 90-277-2601-9 5. O. Huber and J. Szejtli (eds.): Proceedings of the Fourth International Symposium on Cyclodextrins, Munich, F.R.G. (1988).1988 ISBN 0-7923-0000-9 6. G. W. Gokel and K. Koga (eds.): United States-Japan Seminar on Host-Guest Chemistry. Proceedings of the U.S.-Japan Seminar on Host-Guest Chemistry, Miami, Florida, U.S.A. (1987). 1989 ISBN 0-7923-0262-1 7. R. M. Izatt and J. S. Bradshaw (eds.): The Pedersen Memorial Issue. 1992 ISBN 0-7923-1723-8

TOPICS IN INCLUSION SCIENCE

1. J. Szejt1i: Cyclodextrin Technology. 1988 ISBN 90-277-2314-1 2. T. Osa and J.L. Atwood (eds.): Inclusion Aspects of Membrane Chemistry. 1991 ISBN 0-7923-1123-X 3. J. Vicens and V. BOhmer (eds.): Calixarenes: A Versatile Class of Macrocyclic Compounds. 1991 ISBN 0-7923-0714-3 4. J. E. D. Davies (ed.): Spectroscopic and Computational Studies of Supramolecular Systems. 1992 ISBN 0-7923-1958-3 5. K.-H. FrOmming and J. Szejtli: Cyclodextrins in Pharmacy. 1993 ISBN 0-7923-2139-1

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