Online Resource 4. Study Quality Criteria (18 Studies Included in the Current Review)

Online Resource 4. Study Quality Criteria (18 studies included in the current review)

High Exposure Areas Low-to-Moderate Exposure Areas Liao 2012 [27] C W Horng C K S Y W X A Lisabet M R Y Mel h u 1997 h h o u a i f h 2010 e a o iker e [35] e a h a d a r [31] d p s 200 n 2 n n e n e i r a h 7 g 0 l 2 d a n i [44] 1 2 2 2 2 2 0 i n t k 2 0 0 0 0 0 0 0 2 o 2 a 0 1 1 0 0 0 9 0 0 w 1 [ 1 0 9 7 9 1 2 0 a 0 3 [ 0 0 9 2 3 [ [ [ [ [ 3 / 1 0 [ ] 2 3 2 3 3 8 1 0 [ 0 3 8 6 9 7 0 ] 1 4 8 4 ] ] ] ] ] [ 2 [ ] [ 3 ] 4 3 2 3 9 ] ] - 4 0 ] All studies Was □ □ ■ ■ ■ □ ■ □ ■ ■ ■ □ □ □ □ □ expo sure asses sed at the indiv idual /hou sehol d level ? Was □ □ □ ■ ■ □ □ □ □ □ ■ □ □ □ □ □ expo sure asses sed usin Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] g a biom arker ? Wer □ □ □ □ □ ■ □ □ □ □ ■ ■ □ □ □ □ e ou tc o m es ba se d on ob je cti ve te sts or st an da rd cri ter ia in ≥9 0 % of st ud y pa rti ci pa nt s? Did ■ □ ■ ■ ■ ■ ■ □ ■ ■ ■ ■ □ □ □ □ the auth

Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] ors prese nt inter nal com paris ons withi n stud y parti cipa nts? Did ■ ■ ■ □ ■ ■ ■ ■ ■ ■ ■ ■ ■ □ ■ ■ th e au th or s co nt ro l fo r po te nti al co nf ou nd in g ris k fa ct or s in ad dit Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] io n to ag e? Follow -up studies (cohort s with interna l and externa l compa risons) Was ■ □ ■ - ■ - ■ □ ■ - - ■ □ □ □ □ loss to follo w-up inde pend ent of expo sure? Was □ □ □ - □ - □ □ □ - - ■ □ □ □ □ the inten sity of searc h of disea se inde pend ent of expo sure statu s? Case- control

Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] and cross- section al studies Wer - - - □ - ■ - - - ■ □ - - - - - e the data colle cted in a simil ar man ner for all parti cipa nts? Wer - - - □ - ■ - - - ■ □ - - - - - e the same excl usio n criter ia appli ed to all parti cipa nts? Was - - - □ - ■ - - - ■ □ - - - - - th e ti m e pe ri od ov er w

Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] hi ch ca se s an d no nc as es or ex po se d an d no ne xp os ed pa rti ci pa nt s w er e int er vi e w ed th e sa m e? Was - - - □ - □ - - - □ □ - - - - - th e int Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] er vi e w er bli nd ed wi th re sp ec t to th e ca se or ex po su re st at us of th e pe rs on int er vi e w ed ? Was - - - □ - □ - - - □ □ - - - - - the resp onse rate amo ng Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] nonc ases at least 70% ? Wer - - - □ - □ - - - □ □ - - - - - e all cases inter view ed withi n 6 mont hs of diag nosis ? Was - - - □ - □ - - - □ ■ - - - - - the stud y base d on incid ent cases of disea se? Wer - - - □ - ■ - - - □ □ - - - - - e non- cases peop le who, had they deve lope d the disea se, woul

Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected] d have been cases ? ■ fulfilled; □ not fulfilled or information not available; - not applicable

Current Atherosclerosis Reports Arsenic and Cardiovascular Disease: An Updated Systematic Review Katherine Moon, Eliseo Guallar , Ana Navas-Acien* * Departments of Environmental Health Science and Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health; [email protected]