Learning Guide: Molecular Genetics s1

Learning Guide: Molecular Genetics Bill Activity #40 To Think About: How is DNA, and in some cases RNA, the primary source of heritable information? How is heritable information passed to the next generation in eukaryotes, and how do changes in genotype result in changes in phenotype of an organism?

1st Interact: Take notes on Mr. Andersen’s DNA and RNA Part 1 Video by using the flow chart and video guide http://www.bozemanscience.com/027-part-1-dna-rna

2nd Read About: The Molecular Basis of Inhertance: Pgs. 305-322 Campbell’s Biology 9th edition  DNA is the genetic material o Summarize the research of the following people: Griffith (and transformations), Avery, McCarty and MacLeod, Hershey and Chase, Chargraff, Wilkins and Franklin, Watson and Crick o Describe the structure of DNA and the building blocks (nucleotides), explain the difference between purines and pyrimidines  Many proteins work together in DNA replication and repair o Explain the purpose of DNA replication and why it is called semiconservative o Study the text and diagrams on pgs. 313-319. List and define the following: origins of replication, replication fork, helicases, single-stranded binding proteins, topoisomerase, primer, primase, DNA polymerase, leading strand, lagging strand, Okazaki fragments, DNA ligase o Describe how proofreading occurs, include definitions of nuclease and nucleotide excision repair o Explain the role of telomerase  A chromosome consists of a DNA molecule packed together with proteins o Describe the difference between a bacterial chromosome and a eukaryotic chromosome (also explain the difference between heterochromatin and euchromatin.

3rd Interact: Take notes on Mr. Andersen’s Replication Video

4th Interact: Take notes on Mr. Andersen’s DNA and RNA Part 2 Video using the flow chart and video guide http://www.bozemanscience.com/027-part-2-dna-rna

5th Read About: From Gene to Protein Ch. 17 pgs. 325-350 Skim these pages for you to get a feel for the processes of transcription and translation.

Supplementary Resources: Click the links below for more information to help you learn more about this lesson.  Crash Course Biology: DNA Structure and Replication http://www.youtube.com/watch?v=8kK2zwjRV0M  Crash Course Biology: DNA Transcription and Translation http://www.youtube.com/watch?v=itsb2SqR-R0  DNA From the Beginning: Molecules of Genetics  University of Utah Genetic Science Learning Center: DNA to Protein Learn More: For more information about DNA, RNA, their processes and their history, follow the links below: Learn More: For more information about DNA, RNA, their processes and their history, follow the links below:  Nobelprize.org: DNA – The Double Helix Game  Nobelprize.org: The Nobel Prize in Physiology or Medicine 1962—Watson, Crick and Wilkins  Nobelprize.org: The Nobel Prize in Physiology or Medicine 1965—Jacob, Lwoff and Monod (operons)  Nobelprize.org: The Nobel Prize in Physiology or Medicine 1968—Holley, Khorana and Nirenberg (genetic code)  Nobelprize.org: The Nobel Prize in Physiology or Medicine 1978—Arber, Nathans and Smith (restriction enzymes)  Nobelprize.org: The Nobel Prize in Physiology or Medicine 2006—Fire and Mello (RNAi)  Nobelprize.org: The Nobel Prize in Chemistry 1993—Mullis and Smith (development of PCR)  Nobelprize.org: The Nobel Prize in Chemistry 1980—Berg, Gilbert and Sanger (DNA sequencing and rDNA)