Table 3. Down-Regulated Proteins in Quantitative Phosphoproteomics

Table 3. Down-regulated proteins in quantitative phosphoproteomics

Protein Entrez Gene Name Position T-vs-C ID A2AB5 544817 Arhgap27 215 0.55745 9 A2AB5 544817 Arhgap27 155 0.34113 9 3 A2AHC 227634 Camsap1 1133 0.61534 3 7 A2RSJ4 75089 Uhrf1bp1l 418 0.66020 4 A6H8H 329877 Dennd4c 987 0.439 2 B2RUR 433619 Kprp 491 0.15509 4 2 B9EKR 19283 Ptprz1 1680 0.64222 1 3 P50446 16687 Krt6a 531 0.65156 Q99PS0 94179 Krt23 33 0.40562 2 E9Q557 109620 Dsp 2219 0.54018 3 E9Q557 109620 Dsp 2221 0.44923 3 F6ZDS4 108989 Tpr 1259 0.66082 9 F8VQB 17909 Myo10 1887 0.49187 6 7 O09044 20619 Snap23 110 0.45146 4 O70251 55949 Eef1b2 106 0.64242 7 O70318 13822 Epb41l2 698 0.66221 6 O70493 55988 Snx12 73 0.60271 6 O88351 16150 Ikbkb 675 0.64285 6 O88792 16456 F11r 285 0.63459 1 P05213 22143 Tuba1b 48 0.37307 3 P07356 12306 Anxa2 18 0.56851 2 P10107 16952 Anxa1 37 0.46518 6 P11531 13405 Dmd 3616 0.63521 1

1 P12382 18641 Pfkl 775 0.48489 2 P14069 20200 S100a6 46 0.60239 6 P16056 17295 Met 988 0.61994 1 P16056 17295 Met 995 0.53179 5 P23927 12955 Cryab 59 0.65409 7 P26645 17118 Marcks 27 0.52062 8 P27546 17758 Map4 475 0.62476 P30999 12388 Ctnnd1 346 0.57203 7 P30999 12388 Ctnnd1 349 0.61932 1 P30999 12388 Ctnnd1 300 0.65449 5 P46938 22601 Yap1 94 0.64773 4 P47713 18783 Pla2g4a 726 0.65962 5 P47757 12345 Capzb 263 0.53479 9 P48193 269587 Epb41 678 0.65211 1 P50136 12039 Bckdha 344 0.61903 5 P51150 19349 Rab7 72 0.51678 2 P51859 15191 Hdgf 132 0.66566 8 P51906 20510 Slc1a1 516 0.51176 2 P51906 20510 Slc1a1 521 0.57111 5 P53986 20501 Slc16a1 482 0.54347 7 P55012 20496 Slc12a2 74 0.49209 7 P57776 66656 Eef1d 133 0.64875 5 P58871 228140 Tnks1bp1 869 0.58699 6 P58871 228140 Tnks1bp1 912 0.60849 8 P58871 228140 Tnks1bp1 977 0.63596 3

2 P59242 70737 Cgn 149 0.62746 5 P62960 22608 Ybx1 165 0.58414 2 P70268 320795 Pkn1 920 0.51994 4 P70441 26941 Slc9a3r1 283 0.54101 6 P70441 26941 Slc9a3r1 286 0.49459 6 P70441 26941 Slc9a3r1 289 0.57106 7 P70441 26941 Slc9a3r1 294 0.52389 3 P83741 232341 Wnk1 1256 0.58582 4 P83741 232341 Wnk1 2027 0.59897 5 P97792 13052 Cxadr 332 0.58159 2 Q0KL02 223435 Trio 2632 0.61391 9 Q0VAV 320051 Exph5 331 0.66312 2 9 Q2VIS4 229574 Flg2 1198 0.66530 8 Q3U0J8 67016 Tbc1d2b 959 0.62255 Q3UH6 77569 Limch1 719 0.53738 8 8 Q3UIL6 233765 Plekha7 553 0.51721 9 Q3UIL6 233765 Plekha7 362 0.59828 2 Q3UIL6 233765 Plekha7 609 0.65979 8 Q3UPF5 78781 Zc3hav1 350 0.65104 1 Q3URU 18616 Peg3 235 0.56138 2 Q3URU 18616 Peg3 1049 0.42804 2 8 Q3URU 18616 Peg3 97 0.56524 2 9 Q3UW5 63913 Fam129a 581 0.41682 3 9 Q5SWU 107476 Acaca 23 0.65504 9 8 Q5SWU 107476 Acaca 29 0.61071 9 2

3 Q5SYD 338367 Myo1d 553 0.46727 0 8 Q60864 20867 Stip1 481 0.65708 Q60875 16800 Arhgef2 646 0.61754 6 Q60875 16800 Arhgef2 151 0.48245 5 Q61526 13867 Erbb3 684 0.58471 3 Q62313 22134 Tgoln1 267 0.64403 8 Q62417 20411 Sorbs1 1209 0.61867 6 Q62422 20409 Ostf1 203 0.59073 4 Q62433 17988 Ndrg1 330 0.66059 1 Q64337 18412 Sqstm1 266 0.53298 8 Q64512 19249 Ptpn13 901 0.66536 6 Q64512 19249 Ptpn13 1310 0.60186 Q64512 19249 Ptpn13 1735 0.59578 3 Q64512 19249 Ptpn13 1738 0.43084 5 Q64512 19249 Ptpn13 1504 0.66479 7 Q64512 19249 Ptpn13 1596 0.63933 6 Q64512 19249 Ptpn13 1002 0.55700 7 Q64512 19249 Ptpn13 883 0.57777 8 Q6IR34 67839 Gpsm1 490 0.50306 9 Q6P9L6 209737 Kif15 568 0.57159 7 Q6P9Q6 338355 Fkbp15 344 0.59437 Q71FD5 387524 Znrf2 20 0.64476 4 Q7TQK 70829 Ccdc93 305 0.36660 5 2 Q80TH2 59079 Erbin 869 0.56024 1 Q80X90 286940 Flnb 983 0.65254 4 Q8BH6 259300 Ehd2 468 0.57288 4 4

4 Q8BHK 236930 Ercc6l 1021 0.64632 9 Q8BHL 232431 Gprc5a 303 0.66224 4 3 Q8BT07 74107 Cep55 426 0.60417 2 Q8BTM 192176 Flna 1084 0.56195 8 9 Q8BWY 224171 C330027C09Rik 899 0.64658 9 8 Q8C0E2 69091 Vps26b 302 0.64021 6 Q8C0N 231510 Agpat9 68 0.65261 2 5 Q8C180 327826 Frs2 428 0.65664 9 Q8C7E7 52331 Stbd1 167 0.31358 4 Q8C7E7 52331 Stbd1 137 0.65058 3 Q8CHW 212733 Ccdc64b 350 0.40423 5 5 Q8K072 72549 Reep4 152 0.48537 7 Q8K087 241070 Gpr1 347 0.49010 2 Q8K0T0 104001 Rtn1 350 0.34623 7 Q8K0T0 104001 Rtn1 352 0.36024 5 Q8K124 102595 Plekho2 395 0.65777 7 Q8K2T8 54624 Paf1 460 0.60180 6 Q8K2T8 54624 Paf1 466 0.60180 6 Q8R5F7 71586 Ifih1 289 0.64066 3 Q8R5F7 71586 Ifih1 1022 0.55747 4 Q8VC2 380712 Tlcd2 251 0.60554 6 9 Q91W6 71889 Epn3 387 0.61005 9 3 Q91W9 104445 Cdc42ep1 207 0.55856 2 9 Q91WB 71801 Plekhf2 226 0.6194 4 Q91Z58 224833 AI661453 368 0.65656

5 7 Q922J3 56430 Clip1 194 0.65233 5 Q922J3 56430 Clip1 203 0.62970 2 Q99JB8 80708 Pacsin3 319 0.44095 4 Q99JZ7 74155 Errfi1 325 0.60411 Q99K70 54170 Rragc 94 0.65952 2 Q99LH9 79566 Sh3bp5l 342 0.48557 9 Q99MI1 111173 Erc1 191 0.65000 9 Q99PI5 64898 Lpin2 106 0.54133 9 Q9CQ2 66508 Lamtor1 55 0.65560 2 1 Q9CR86 52502 Carhsp1 31 0.47471 Q9CWK 67804 Snx2 117 0.64621 8 2 Q9CZE 67844 Rab32 69 0.61446 3 3 Q9DBS 71720 Osbpl3 405 0.54610 9 8 Q9DBS 71720 Osbpl3 272 0.60183 9 2 Q9DBS 71720 Osbpl3 33 0.43886 9 8 Q9DBS 71720 Osbpl3 250 0.62914 9 Q9DBX 67466 Pdcl 293 0.61598 2 9 Q9ERU 19386 Ranbp2 2348 0.56905 9 3 Q9ESL4 65964 Zak 567 0.60662 Q9ET54 72333 Palld 901 0.57693 7 Q9JLF6 21816 Tgm1 94 0.60164 3 Q9QXZ 11426 Macf1 4458 0.55845 0 5 Q9QYG 29811 Ndrg2 338 0.65290 0 8 Q9QZQ 17356 Afdn 1719 0.65207 1 6 Q9QZQ 17356 Afdn 1722 0.63575 1 9 Q9QZQ 17356 Afdn 1083 0.65722

6 1 2 Q9R020 53861 Zranb2 153 0.28440 4 Q9WTQ 83397 Akap12 1290 0.50110 5 9 Q9WTQ 83397 Akap12 235 0.34354 5 8 Q9WTU 18676 Phf2 715 0.54611 0 7 Q9WV9 19221 Ptgfrn 875 0.59419 1 2 Q9Z0U1 21873 Tjp2 988 0.50676 4 Q9Z204 15381 Hnrnpc 229 0.66480 7 A2RSJ4 75089 Uhrf1bp1l 420 0.66020 4 B9EKR 19283 Ptprz1 1684 0.64222 1 3 P50446 16687 Krt6a 281 0.56959 9 F8VQB 17909 Myo10 1886 0.51426 6 8 O35639 11745 Anxa3 106 0.66419 5 P05213 22143 Tuba1b 51 0.42458 9 P07356 12306 Anxa2 19 0.64104 8 P23927 12955 Cryab 63 0.43452 8 P42932 12469 Cct8 398 0.55273 4 P70441 26941 Slc9a3r1 288 0.53529 8 Q3UIA2 70497 Arhgap17 164 0.37754 Q61510 217069 Trim25 84 0.61712 Q64337 18412 Sqstm1 269 0.49633 9 Q64337 18412 Sqstm1 271 0.45007 3 Q64337 18412 Sqstm1 272 0.64123 5 Q68FD5 67300 Cltc 394 0.61122 Q6ZQ58 73158 Larp1 1048 0.66575 7 Q8CEC 19069 Nup88 526 0.60860 0 4 Q8CFI0 83814 Nedd4l 480 0.66218

7 8 Q99K70 54170 Rragc 380 0.65741 5 Q99MI1 111173 Erc1 188 0.65000 9 Q9CQ2 66508 Lamtor1 28 0.63199 2 3 Q9D952 14027 Evpl 2028 0.65884 5 Q9DBS 71720 Osbpl3 248 0.51994 9 8 Q9ESK 12421 Rb1cc1 238 0.63683 9 3 Q9JLF6 21816 Tgm1 103 0.56886 5 Q9Z0G9 12739 Cldn3 209 0.44932 7 F8VQB 17909 Myo10 260 0.35962 6 F8VQB 17909 Myo10 264 0.35962 6