UNC Tox 207 Reference List

UNC Tox 207 Reference List Hepatic Toxicology – Response to Hepatic Injury

Brunk, U. T., Jones, C.B., & Sohal, R. S. (1992). A Novel Hypothesis of Lipofuscinogenesis and Cellular Aging Based on Interactions Between Oxidative Stress and Autophagocytosis. Mutation Research, 275, 395-403.

Conway, J.G., Tomaszewski, K. E., Olson, M.J., Cattley, Marsman, D.S., & Popp, J.A. (1989). Relationship of Oxidative Damage to the Hepatocarcinogenicity of the Peroxisome Proliferators Di(2-ethylhexyl)phthalate and Wy- 14,643 Carcinogenesis 10 (3), 513-519.

Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM. [2001]. Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett, 502(1-2), 4-10.

Gerber, M.A. & Thung, S.N. (1993). Liver Stem Cells and Development. Laboratory Investigation 68, 253-254.

*Fausto N (2000). Liver Regeneration. Journal of Hepatology 32(1 Suppl):19-31.

*Fausto N (2005). Mechanisms of Liver Regeneration and Their Clinical Implications Journal of Hepatobiliary Pancreatic Surgery 12(3):181-9.

*Friedman SL (2000). Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. Journal of Biological Chemistry 28;275(4):2247-50.

*Friedman, SL (2004). Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol. 1(2):98-105. Review.

Hui AY and Friedman SL (2003). Molecular Basis of Hepatic Fibrosis. Expert Reviews in Molecular Medicine. 1-23

Kanzler S, Lohse AW, Keil A, Henninger J, Dienes HP, Schirmacher P, Rose-John S, zum Buschenfelde KH, Blessing M (1999). TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. American Journal of Physiology 276(4 Pt 1):G1059-68.

Thorgeirsson, S.S. (1993). Hepatic Stem Cells. American Journal of Pathology, 142 (5), 1331-1333.

Tiggleman, A.M., Linthorst, C., Boers, W., Brand, H.S., Chamuleau, R.A. (1997). Transforming Growth Factor-Beta- Induced Collagen Synthesis by Human Liver Myofiboroblasts is Inhibited by Alpha2 - Macroglobulin. Journal of Hepatology, 26 (6), 1220-1228.

*Walkup, M.H., Gerber, D.A. (2006) Hepatic Stem Cells: In Search Of. Stem Cells. 24(8):1833-40.

Yamamoto, H., Murawaki, Y., & Kawasaki, H. (1995). Hepatic Collagen Synthesis and Degradation During Liver Regeneration after Partial Hepatectomy. Hepatology, 21, 155-161.

* - most important.