The Mouse Universal Genotyping Array: from Substrains to Subspecies
G3: Genes|Genomes|Genetics Early Online, published on December 18, 2015 as doi:10.1534/g3.115.022087 INVESTIGATIONS The Mouse Universal Genotyping Array: from substrains to subspecies Andrew P Morgan∗, †, 1, Chen-Ping Fu‡, 1, Chia-Yu Kao‡, Catherine E Welsh§, John P Didion∗,†, Liran Yadgary∗,†, Leeanna Hyacinth∗,†, Martin T Ferris∗,†, Timothy A Bell∗,†, Darla R Miller∗,†, Paola Giusti-Rodriguez∗,†, Randal J Nonneman∗,†, Kevin D Cook∗,†, Jason K Whitmire∗,†, Lisa E Gralinski∗∗,†, Mark Keller††, Alan D Attie††, Gary A Churchill‡‡, Petko Petkov‡‡, Patrick F Sullivan∗, †, §§, Jennifer R Brennan∗ ∗ ∗, Leonard McMillan‡ and Fernando Pardo-Manuel de Villena∗,† ∗Department of Genetics, University of North Carolina, Chapel Hill, NC, †Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, ‡Department of Computer Science, University of North Carolina, Chapel Hill, NC, §Department of Mathematics and Computer Science, Rhodes College, Memphis, TN, ∗∗Department of Epidemiology, University of North Carolina, Chapel Hill, NC, ††Department of Biochemistry, University of Wisconsin, Madison, WI, ‡‡The Jackson Laboratory, Bar Harbor, ME, §§Department of Psychiatry, University of North Carolina, Chapel Hill, NC, ∗ ∗ ∗Mutant Mouse Resource and Research Center, University of North Carolina, Chapel Hill, NC, 1These authors contributed equally. ABSTRACT Genotyping microarrays are an important resource for genetic mapping, population genetics KEYWORDS and monitoring of the genetic integrity of laboratory stocks. We have developed the third generation of microarrays the Mouse Universal Genotyping Array (MUGA) series, GigaMUGA, a 143,259-probe Illumina Infinium II genetic mapping array for the house mouse (Mus musculus). The bulk of the content of GigaMUGA is optimized for genetic inbred strains mapping in the Collaborative Cross and Diversity Outbred populations and for substrain-level identification ..
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