Alcohol Use, Vascular Disease, and Lipid-Lowering Drugs

The Journal of PHARMACOLOGY And Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

July 2006 Vol. 318, No. 1 Contents

PERSPECTIVES IN PHARMACOLOGY Genovefa D. Kolovou, Klelia D. Salpea, Alcohol Use, Vascular Disease, and Lipid-Lowering Drugs Katherine K. Anagnostopoulou, and Dimitri P. Mikhailidis

BEHAVIORAL PHARMACOLOGY Antinociceptive Pharmacology of iV-[[4-(4,5-Dihydro-lff- F. Porreca, T. W. Vanderah, W. Guo, imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6- dimethylphenyl) sulfonyl]methylamino]ethoxy]-A'- 195 methylacetamide, Fumarate (LF22-0542), a Novel Nonpeptidic M. Barth, P. Dodey, V. Peyrou, Bradykinin B, Receptor Antagonist J. M. Luccarini, J.-L. Junien, and D. Pruneau Relative Reinforcing Effects of Cocaine, Remifentanil, and Their Combination in Rhesus Monkeys Endogenous Orphanin FQ/Nociceptin Is Involved in the G. Winger, C. M. Galuska, S. R. Hursh, and Development of Morphine Tolerance 223 CARDIOVASCULAR J. H. Woods Induction of Heme Oxygenase-1 Is Involved in Carbon Shinjae Chung, Sigrun Pohl, Joanne Zeng, Monoxide-Mediated Central Cardiovascular Regulation Pleiotropic Effects of the J3-Adrenoceptor Blocker Carvedilol 262 on Calcium Regulation during Oxidative Stress-Induced Olivier Civelli, and Rainer K. Reinscheid Apoptosis in Cardiomyocytes

Wan-Chen Lo, Pei-Jung Lu, Wen-Yu Ho, 8 Role of Phosphorus and Vitamin D Analogs in the Michael Hsiao, and Ching-Jiunn Tseng Pathogenesis of Vascular Calcification Ruijuan Wang, Toshiro Miura,

45 Nozomu Harada, Ryosuke Kametani, A^-(3-Iodobenzyl)-adenosine-5'-iV-niethylcarboxamide Confers Masaki Shibuya, Yasuhiro Fukagawa, Shuji Cardioprotection at Reperfusion by Inhibiting Mitochondrial Kawamura, Yasuhiro Ikeda, Masayuki Hara, Permeability Transition Pore Opening via Glycogen Synthase and Masunori Matsuzaki Kinase 3/3 J. Ruth Wu-Wong, William Noonan, Volatile Anesthetic Preconditioning Attenuates Myocardial Apoptosis in Rabbits after Regional Ischemia and Reperfusion 90 via Akt Signaling and Modulation of Bcl-2 Family Proteins Junli Ma, Doug Dixon, Masaki Nakane, Blocking Late Sodium Current Reduces Hydrogen Peroxide- Antoinette L. Bolin, Kristin A. Koch, Steve Induced Arrhythmogenic Activity and Contractile Dysfunction Postl, Sherry J. Morgan, and Glenn A. Reinhart Sung-Sik Park, Hong Zhao, Yeongho Jang,

124 Robert A. Mueller, and Zhelong Xu

Jacob Raphael, Suzan Abedat, Julia Rivo,

186 Karen Meir, Ronen Been, Thea Pugatsch, Zhiyi Zuo, and Yaacov Gozal Yejia Song, John C. Shryocfc, 214 Stefan Wagner, Lars S. Maier, and Luiz Belardinelli Central Adenosine Signaling Plays a Key Role in Centrally Mediated Hypotension in Conscious Aortic Barodenervated Rats Noha Nassar and Abdel A. Abdel-Rahman 255 Augmented Endothelium-Derived Hyperpolarizing Factor- Mediated Relaxations Attenuate Endothelial Dysfunction in Yi Shi, David D. Ku, Ricky Y. K. Man, and 276 Femoral and Mesenteric, but Not in Carotid Arteries from Paul M. Vanhoutte Type r Diabetic Rats Increased RhoA/Rho-Kinase Signaling Mediates Spontaneous Tone in Aorta from Angiotcnsin II-Induced Hypertensive Rats Liming Jin, Zhekang Ying, 288 Rob H. P. Hilgers, Jia Yin, Xueying Zhao, Synthetic Peroxisome Proliferator-Activated Receptor-y John D. Imig, and R. Clinton Webb Agonists Restore Impaired Vasorelaxation via ATP-Sensitive Hiroyuki Kinoshita, Toshiharu Azma, 312 K+ Channels by High Glucose Hiroshi tranami, Katsutoshi Nakahata, Yoshiki Kimoto, Mayuko Dojo, Sesamin Metabolites Induce an Endothclial Nitric Oxide- Osafumi Yuge, and Yoshio Hatano Dependent Vasorelaxation through Their Antioxidative Daisuke Nakano, Chol-Jun Kwak, Kiwako 328 Property-Independent Mechanisms: Possible Involvement of Fujii, Kenjj Ikemura, Aiko Satakc, Mamoru the Metabolites in the Antihypertensive Effect of Sesamin Ohkita, Masanori Takaoka, Yoshiko Ono, Masaaki Nakai. Namino Tomimori, Yoshinobu Kiso, and Yasuo Matsumura The Emerging Cardioinhibitory Role of the Hippocampal Tommaso Angelone, Yannick Goumon, Cholinergic Neurostimulating Peptide Maria Carmela Cerra, Marie-Helene Metz- 336 Boutiguc, Dominique Aunis, and Bruno Tota Todd Wisialowski. Kimbcrly Criinin, Differentiation of Arrhythmia Risk of the Antibacterials Juntyma Engtrakul, John O'Donnell, Moxifloxacin, Erythromycin, and Telithromycin Based on Bernard Fermini, and Anthony A. Fossa 352 Analysis of Monophasic Action Potential Duration Alternans and Cardiac Instability Sharon L, Hale, Justin A. Lceka, and Improved Left Ventricular Function and Reduced Necrosis Robert A, Kloncr after Myocardial Ischemia/Reperfusion in Rabbits Treated 418 with Ranolazine, an Inhibitor of the Late Sodium Channel

CELLULAR AND MOLECULAR B. Frazier Taylor, Samuel C. McNeely, p53 Suppression of Arsenite-Induced Mitotic Catastrophe Is CIP1/WAF1 Heather L. Miller, Geniece M. Lchmann, Mediated by p21 Michael J. McCabe, Jr., and J. Christopher 142 States Jin-Ah Kim, Jin-Yong Park, Ho-Won Kang, Augmentation of Cav3.2 T-Type Calcium Channel Activity by Sung-Un Huh, Seong-Woo Jeong, and Jung- cAMP-Dependent Protein Kinase A Ha Lee 230 Manickavasagom Alkondon and Subtype-Specific Inhibition of Nicotinic Acetylcholine Edson X. Albuquerque Receptors by Choline: A Regulatory Pathway Andres A. Caro and Arthur I. Cederbaum 268 Role of Phosphatidylinositol 3-Kinase/AKT as a Survival Pathway against CYP2K1 -Dependent Toxicity David Alonso-Escolano, Carlos Medina, 360 Protein Kinase C5 Mediates Platelet-Induced Breast Cancer Katarzyna Cieslik, Anna Radomski, Paul Cell Invasion Jurasz, Maria Jose Santos-Martinez, Tilahum 373 Jiffar. Peter Ruvolo, and Marek W. Radomski

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY Inhibition of Protein Kinase c-Src Reduces the Incidence of Nadia Rucci, Irene Recchia, 161 Breast Cancer Metastases and Increases Survival in Mice: Adriano Angelucci, Marina Alamanou, Implications for Therapy Andrea Del Faitore, Dario Fortunati, Mira Susa, Doriano Fabbro, Mauro Bologna, and Anna Teti Blockade of Angiogenesis by Small Molecule Antagonists to Panagiota Zania, Sosanna Kritikou, 246 Protease-Activated Receptor-1: Association with Endothelial Christodoulos S. Flordellis, Michael Cell Growth Suppression and Induction of Apoptosis E. Maragoudakis, and Nikos E. Tsopanoglou

ENDOCRINE AND DIABETES Cilostazol Protects Diabetic Rats from Vascular Inflammation Ling Gao, Furong Wang, Bo Wang, 53 via Nuclear Factor-KB-Dependent Down-Regulation of Bendi Gong, Jie Zhang, Xiumei Zhang, and Vascular Cell Adhesion Molecule-1 Expression Jiajun Zhao Preventive and Therapeutic Potential of p38«-Selective Salyanarayana Medicherla, Mitogen-Activated Protein Kinase inhibitor in Nonobese Diabetic Mice with Type 1 Diabetes 99 Andrew A. Protter, Jing Ying Ma, Differential Modulation of Cav1.2 and Cav1.3-Mediated Ruban Mangadu, Ramona Almirez, Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells: Bruce Koppelman, Irene Ken*, Distinct Roles for Exchange Protein Directly Activated by Tony A. Navas, Fabiola Movius, cAMP 2 (Epac2) and Protein Kinase A Mamalha Reddy, Yu-Wang Liu, Gregory Luedtke, John Perumattam, GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Babu Mavunkel, Sundeep Dugar, and Iinmunomodulatory Therapeutic Effect of Glatiramer Acetate George F. Schreiner on Several Murine Models of Inflammatory Bowel Disease Guohong Liu, Sarah Melissa P. Jacobo,

152 Nathan Hilliard, and Gregory H. Hockerman

Rina Aharoni, Basak Kayhan, Ori Brenner, Hagit Domcv, Galya Labunskay, and Ruth Arnon

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA (5ff)-5-Hydroxytriptolide Attenuated Collagen-Induced Ru Zhou, Wei Tang, Yong-Xin Ren, Arthritis in DBA/1 Mice via Suppressing Interferon-y Production and Its Related Signaling 35 Pei-Lan He, Fan Zhang, Li-Ping Shi, Yun- Feng Fu, Yuan-Chao Li, Shiro Ono, Hiromi Inhibition of Nuclear Factor-wE Enhances the Capacity of Fujiwara, Yi-Fu Yang, and Jian-Ping Zuo Immature Dendritic Cells to Induce Antigen-Specific Mirentxu I. Iruretagoyena, Tolerance in Experimental Autoimmune Encephalomyelitis 59 Soffa H. Sepulveda, J. Pablo Lezana, Glycogen Synthase Kinase-30 Inhibition Reduces Secondary Marcela Hermoso, Miguel Bronfman, Damage in Experimental Spinal Cord Trauma Miguel A. Gutierrez, Sergio H. Jacobelli, and Alexis M. Kalergis Salvatore Cuzzocrea, Tiziana Genovese,

A Selective p38(* Mitogen-Activated Protein Kinase Inhibitor 79 Reverses Cartilage and Bone Destruction in Mice with Bmanuela Mazzon, Concetta Crisafulli, Collagen-Induced Arthritis Rosanna Di Paola, Carmelo Muia, Marika Collin, Emanuela Esposito, Placido Bramanti, and Christoph Thicmcrmann Satyanarayana Medicherla, Jing Ying Ma,

Nuclear Factor-KB-Independent Anti-Inflammatory Action of 132 Salicylate in Human Endothelial Cells: Induction of Heme Ruban Mangadu, Yebin Jiang, Oxygenase-1 by the c-Jun N-Terminal Kinase/Activator Jenny J. Zhao, Ramona Almirez, Trene Kcrr, Protein-1 Pathway Elizabeth G. Stebbins, Gilbert O'Young, Selective Inhibition of Eosinophil Influx into the Lung by Ann M. Kapoun, Gregory Lucdtkc, Small Molecule CC Chemokine Receptor 3 Antagonists in Sarvajit Chakravarty, Sundeep Dugar, Mouse Models of Allergic Inflammation Harry K. Gcnant, and Andrew A. Protter Robert Fiirst, Signe B. Blumenthal, 389 Alexandra K. Kiemer, Stefan Zahler, and Angelika M. Vollmar

Anuk M. Das, Krishna G. Vaddi, 411 Kimberly A. Solomon, Candice Krauthauser, Xiaosui Jiang, Kim W. Mclntyre, Xiao Xia Yang, Eric Wadman, Patricia Welch, Maryannc Covington, Danielle Graden, Krishnaswamy Yeleswaram, James M. Trzaskos, Robert C. Newton, Sandhya Mandlekar, Soo S. Ko, Percy H. Carter, and Paul Davies

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS Metabolism of Efavirenz and 8-Hydroxyefavirenz Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: by P450 2B6 Leads to Inactivation by Two Distinct Studies Using Mrp2 (Abccl) Knockout Mice Mechanisms Vectorial Transport of Enalapril by Oatplal/Mrp2 and OATP1B1 and OATP1B3/MRP2 in Rat and Human Livers M. L. H. Vlaming, K. Mohrmann,

319 E. Wagenaar, D. R. de Waart, R. P. J. Oude Elferink, J. S. Lagas, O. van Tellingen, L. D. Vainchtein, H. Rosing, J. H. Beijnen, J. H. M. Schellens, and A. H. Schinkcl Namandje N. Bumpus, Ute M. Kent, and 345 Paul F. Hollcnbcrg Lichuan Liu, Yunhai Cui, Alfred Y. Chung, 395 Yoshihisa Shitara, Yuichi Sugiyama, Dietrich Keppler, and K. Sandy Pang Paclitaxel and Docetaxel Stimulation of Doxorubicinol Emanuela Salvatorelli, Pierantonio Menna, 424 Formation in the Human Heart: Implications for Sabrina Cascegna, Giovanni Liberi, Cardiotoxicity of Doxorubicin-Taxane Chemotherapies Antonio M. Calafiore, Luca Gianni, and Giorgio Minotti Transport Characteristics of a Novel Peptide Transporter 1 Masahiro Tsuda, Tomohiro Terada, 455 Substrate, Antihypotensive Drug Midodrine, and Its Amino Megumi Me, Toshiya Katsura, Acid Derivatives Ayumu Niida, Kenji Tomita, Nobutaka Fujii, and Ken-ichi Inui

NEUROPHARMACOLOGY Physiological and Biophysical Factors That Influence Karunya K. Kandimalla, Geoffry L. Curran, Alzheimer's Disease Amyloid Plaque Targeting of Native and Putrescine Modified Human Amyloid 040 17 Silvina S. Holasek, Emily J. Gilles, Thomas M. Wengenack, Marina Interaction of Functionalized Superparamagnetic Iron Oxide Ramirez-Alvarado, and Joseph F. Nanoparticles with Brain Structures Poduslo Feride Cengelli, Dusica Maysinger,

Biphenyl-indanone A, a Positive Allosteric Modulator of the 108 Metabotropic Glutamate Receptor Subtype 2, Has Florianne Tschudi-Monnet, Xavier Montet, Claire Antipsychotic- and Anxiolytic-Like Effects in Mice Corot, Alke Petri-Fink, Heinrich Hoi'mann, and Lucienne Juillerat-Jeanneret Buprenorphine Activates fx and Opioid Receptor Like-1 Ruggero Galici, Carrie K. Jones, Receptors Simultaneously, but the Analgesic Effect Is Mainly Mediated by /i Receptor Activation in the Rat Formalin Test 173 Specific Plasma Membrane Binding Sites for Polyphenols, Kamondanai Hemstapat, Yi Nong, Nicholas Including Resveratrol, in the Rat Brain G. Echemendia, Liliy C. Williams, Tomas de Paulis, and P. Jeffrey Conn Thienorphine Is a Potent Long-Acting Partial Opioid Agonist: A Comparative Study with Buprenorphine Tatsuo Yamamoto, Koyo Shono, and 206 Serabi Tanabe Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling Ying-Shan Han, Stephane Bastianetto, 238 Yvan Dumont, and Remi Quirion Differential Regulation of Mesolimbic a3*/a6/32* and a4/J2* Nicotinic Acetylcholine Receptor Sites and Function after Gang Yu, Yong-Juan Yue, Meng-Xun Cui, 282 Long-Term Oral Nicotine to Monkeys and Ze-Hui Gong Effects of Anesthetics on Mutant A'-Methyl-D-Aspartate Sachin Patcl and Cecilia J. Hillard 304 Receptors Expressed in Xenopus Oocytes

TOXICOLOGY Sarah E. McCallum, Neeraja Parameswaran, 381 Tanuja Bordia, Hong Fan, Enhanced Xenobiotic-Induced Hepatotoxicity and Kupffer Cell J. Michael Mclntosh, and Maryka Quik Activation by Restraint-Induced Stress Junichi Ogata, Munehiro Shiraishi, 434 Nitroglycerin Attenuates Human Endothelial Progenitor Cell Tsunehisa Namba, C. Thetford Smothers, Differentiation, Function, and Survival John J. Woodward, and R. Adron Harris

Paradoxical Effects of Hydrogen Peroxide on Human Airway Sree D. Panuganti, Farah D. Khan, and 26 Anion Secretion Craig K. Svensson Jonathan M. DiFabio, George R. Thomas, 117 Bioactive Properties of Iron-Containing Carbon Monoxide- Liana Zucco, Michael A. Kuliszewski, Brian Releasing Molecules M. Bennett, Michael J. Kutryk, and John D. Parker Takamasa Ohashi, Yasushi Ito, 296 Tadakatsu Matsuno, Shinji Sato, Kaoru The Anti-Inflammatory Drug, Nimesulide (4-Nitro-2- Shimokata, and Hiroaki Kume phenoxymethane-sulfoanilide), Uncouples Mitochondria and Philip Sawle, Jehad Hammad, 403 Induces Mitochondrial Permeability Transition in Human Ian J. S. Fairlamb, Benjamin Moulton, Hepatoma Cells: Protection by Albumin Ciara T. O'Brien, Jason M. Lynam, Anne K. Duhme-Klair, Roberta Foresti, and Roberto Motterlini Alain Berson, Sophie Cazanave, 444 Veronique Descatoire, Marina Tinel, Alain Grodet, Claude Wolf, Gerard Feldmann, and Dominique Pessayre