Curriculum Vitae Europass

Curriculum Vitae

Personal information

First Name, Surname Gabriella TESTA Address Department of Clinical and Biological Science, San Luigi Gonzaga Hospital Regione Gonzole, 10, 10043, Orbassano (Torino), Italy Telephone +39 011 6705444 Mobile: +39 328 9311189 E-mail [email protected] address Nationality Italian Place and Date of birth Cerignola (Fg), 13/02/1984

Work experiences

Date To date (from 1/01/2013) Occupation and position held Research fellowship about the project “Mass spectrometric profile of cholesterol oxidation products in Alzheimer’s brain: oxysterol-induced neurodegeneration and Employer’s name and locality disease progression” Department of Clinical and Biological Sciences, Laboratory of General Pathology, University of Turin, S. Luigi Gonzaga Hospital, Orbassano (To)

Date academic years: 2010/2011 - 2012/2013 Occupation and Lecturer in Chemistry at Science of Medicine and Surgery position held University of Torino, Faculty of Medicine and Surgery, S. Luigi Gonzaga Hospital, Employer’s name and Orbassano (To) locality

Date academic years: 2011/2012 - 2012/2013 Occupation and position held Lecturer in General Pathology at Sciences of motor and sport activities Employer’s name and University of Torino, Interfaculty University School of Motor Sciences, Leinì (To) locality

academic years: 2011/2012 - 2012/2013 – 2013/2014 Date Assistant lecturer in General Pathology and Physiopathology at the Arts in Occupation and Nursing position held University of Torino, S. Luigi Gonzaga Hospital, Orbassano (To) Employer’s name and locality academic years: 2011/2012 - 2012/2013 – 2013/2014

Date Occupation and position held Assistant lecturer in General Pathology and Physiopathology at the Arts in Nursing Employer’s name and locality University of Torino, S. Croce e Carle Hospital, Cuneo (To)

/5 – Gabriella TESTA Curriculum vitae Date academic years: 2011/2012 - 2012/2013 - 2013/2014 Occupation and position held Assistant lecturer in General Pathology at Psychiatric Rehabilitation Technique Employer’s name and University of Torino, S. Luigi Gonzaga Hospital, Orbassano (To) locality

Date academic years: 2009/2010 - 2010/2011 Occupation and position held Teaching assistant in Practice Exercises of General Pathology and Pathophysiology at Science of Medicine Employer’s name and locality and Surgery University of Torino, Faculty of Medicine and Surgery, S. Luigi Gonzaga Hospital, Orbassano (To)

Date November 2008 Occupation and position held Research grant for the project “Oxidized cholesterol and atherosclerotic plaque evolution: molecular analysis and clinical monitoring by serum markers” Employer’s name and University of Torino, Department of Clinical and Biological Sciences, S. Luigi locality Gonzaga Hospital, Orbassano (To)

Education and training

Date 14/02/2013 Qualification awarded PhD in Experimental Medicine and Therapy - Pharmacology and Clinical and Experimental Therapy - XXIV cycle Title of thesis: ”Lipid oxidation products in the pathogenesis of major chronic Education or training diseases” organisation’s name and locality Department of Clinical and Biological Sciences - University of Turin – S. Luigi Gonzaga Hospital, Orbassano (To)

Date 06/02/2008 Qualification awarded Master of Science in Organic Industrial Chemistry and Biochemistry Title of thesis: “New Hyaluronic acid based click-gels: synthesis and characterization” Final mark: 110/110 cum laude Education or training Faculty of Mathematics, Physics and Natural Science - University ‘La Sapienza’ - organisation’s name and locality Rome

Date 13/12/2005 Qualification awarded Bachelor degree in Industrial Chemistry Title of thesis: “Photometric study of NO release from NO-donors” Final mark: 110/110 cum laude Education or training Faculty of Mathematics, Physics and Natural Science - University ‘La Sapienza’ - organisation’s name and locality Rome

/5 – Gabriella TESTA Curriculum vitae Page 3/5 – Gabriella TESTA Curriculum vitae Additional information

Vurusaner B., Gamba P., Testa G., Gargiulo S., Biasi F., Zerbinati C., Iuliano L., Leonarduzzi G., Basaga H., Poli G. Survival signaling elicited by 27-hydroxycholesterol Publications through the combined modulation of cellular redox state and ERK/Akt phosphorylation. Free Radic. Biol. Med., 2014. doi: 10.1016/j.freeradbiomed.2014.07.026.

Testa G., Gamba P., Badilli U., Gargiulo S., Maina M., Guina T., Calfapietra S., Biasi F., Cavalli R., Poli G., Leonarduzzi G. Loading into nanoparticles improves quercetin’s efficacy in preventing neuroinflammation induced by oxysterols. PLoS One, 2014, 9(5):e96795. doi: 10.1371/journal.pone.0096795.

Gamba P., Guglielmotto M., Testa G., Monteleone D., Zerbinati C., Gargiulo S., Biasi F., Iuliano L., Giaccone G., Mauro A., Poli G., Tamagno E., Leonarduzzi G. Up-regulation of - amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetylcysteine. Aging Cell., 2014, in press. doi: 10.1111/acel.12206.

Testa G., Biasi F., Poli G., Chiarpotto E. Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity. Curr. Pharm. Des., 2013 Sep 26. [Epub ahead of print]

Biasi F., Guina T., Maina M., Cabboi B., Deiana M., Tuberoso C.I., Calfapietra S., Chiarpotto E., Sottero B., Gamba P., Gargiulo S., Brunetto V., Testa G., Dessì M.A., Poli G., Leonarduzzi G. Phenolic compounds present in Sardinian wine extracts protect against the production of inflammatory cytokines induced by oxysterols in CaCo-2 human enterocyte-like cells. Biochem. Pharmacol., 2013, 86(1), 138-145.

Biasi F., Chiarpotto E., Sottero B., Maina M., Mascia C., Guina T., Gamba P., Gargiulo S., Testa G., Leonarduzzi G., Poli G. Evidence of cell damage induced by major compo- nents of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line. Biochimie, 2013, 95(3), 632-640.

Gargiulo S., Gamba P., Testa G., Sottero B., Maina M., Guina T., Biasi F., Poli G., Leonarduzzi G. Molecular signaling involved in oxysterol-induced β1-integrin over- expression in human macrophages. Int. J. Mol. Sci., 2012, 13, 14278-14293.

Testa G., Gamba P., Di Scipio F., Sprio A.E., Salamone P., Gargiulo S., Sottero B., Biasi F., Berta G.N., Poli G., Leonarduzzi G. Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal. Free Radic. Biol. Med., 2012, 53(9), 1708-1717.

Gamba P., Testa G., Sottero B., Gargiulo S., Poli G., Leonarduzzi G. The link between al- tered cholesterol metabolism and Alzheimer’s disease. Ann. N. Y. Acad. Sci., 2012, 1259(1), 54-64.

Leonarduzzi G., Sottero B., Testa G., Biasi F., Poli G. New insights into redox-modulated cell signaling. Curr. Pharm. Des., 2011, 17(36), 3994-4006.

Castello L., Maina M., Testa G., Cavallini G., Biasi F., Donati A., Leonarduzzi G., Bergami- ni E., Poli G., Chiarpotto E. Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. Mech. Ageing Dev., 2011, 132(6-7), 305-14.

Gamba P., Leonarduzzi G., Tamagno E., Guglielmotto M., Testa G., Sottero B., Gargiulo S., Biasi F., Mauro A., Viña J., Poli G. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell., 2011, 10(3), 403-17.

Leonarduzzi G., Testa G., Sottero B., Gamba P., Poli G. Design and development of nan- ovehicle-based delivery systems for preventative and therapeutic supplementation with flavonoids. Curr. Med. Chem., 2010, 17(1), 74-95. Page 4/5 – Gabriella TESTA Curriculum vitae

/5 – Gabriella TESTA Curriculum vitae Proceed- Testa G., Gamba P., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Leonarduzzi ings G., Poli G. (2012). Involvement of oxysterols in the pathogenesis of Alzheimer’s disease. (national and international meetings) 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S3, Abstract AGE11.

Gamba P., Testa G., Gargiulo S., Sottero B., Di Scipio F., Sprio A.E., Salamone P., Berta G.N., Leonarduzzi G., Poli G. (2012). Interaction between 4-hydroxynonenal and amyloid-beta in amplifying neuronal damage. 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S3, Abstract AGE12.

Gargiulo S., Gamba P., Sottero B., Testa G., Poli G., Leonarduzzi G. (2012). Role of oxysterols in the progression of atherosclerotic lesions. 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S7, Abstract CVBM7.

Testa G., Gargiulo S., Gamba P., Sottero B., Poli G., Leonarduzzi G. (2012). Involvement of oxysterols in atherosclerotic plaque instability. 16th Biennal Meeting of the Society for Free Radical Research International, London, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S134, Abstract 0347.

Gamba P., Testa G., Gargiulo S., Guglielmotto M., Leonarduzzi G., Poli G. (2012). Interaction between oxidized lipids and amyloid-beta in amplifying neuronal damage in Alzheimer’s disease. 16th Biennal Meeting of the Society for Free Radical Research International, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S244, Abstract HNE.O.9.

Maina M., Testa G., Biasi F., Leonarduzzi G., Poli G., Chiarpotto E. (2012). Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. 16th Biennal Meeting of the Society for Free Radical Research International, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S78, Abstract 0300.

Communications (national and international meetings)

Vurusaner B., Gamba P., Testa G., Gargiulo S., Leonarduzzi G., Basaga H., Poli G. (2013). Oxysterols, ROS production and survival signaling. 1st Cell Death Research Congress, Izmir (Turkey), October 30 – November 3, 2013.

Di Scipio F., Sprio A.E., Salamone P., Gamba P., Testa G., Gargiulo S., Sottero B., Leonarduzzi G., Poli G., Berta G.N. (2013). Dental pulp stem cells: a new tool for studying neurodegenerative diseases. 36° Congresso Nazionale della Società Italiana di Farmacologia “Il ruolo della ricerca farmacologica per la crescita e la salute in Italia”, Torino, October 23-26, 2013.

Testa G., Gamba P., Tamagno E., Guglielmotto M., Monteleone D., Leonarduzzi G., Poli G.(2013). Involvement of oxidized lipids in the pathogenesis of Alzheimer’s disease. SIPMET/ASIP Young Scientists meeting “From general pathology to molecular and translational medicine”, Roma, October 23-24, 2013.

Leonarduzzi G., Gamba P., Testa G., Poli G. (2013). Interaction between lipid oxidation products and amyloid-β in amplifying neuronal damage in Alzheimer’s disease. Gordon Research Seminar “Oxidative Stress & Disease”, Les Diablerets (Switzerland), April 13- 14, 2013.

Gamba P., Testa G., Sottero B., Gargiulo S., Di Scipio F., Sprio A.E., Salamone P., Berta G.N., Leonarduzzi G., Poli G. (2012). Amyloid-β peptide neurotoxicity is potentiated by 4-hydroxynonenal and 24-hydroxycholesterol. 2nd ENOR Symposium on Oxysterols and Page 6/5 – Gabriella TESTA Curriculum vitae

Testa G., Gamba P., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Leonarduzzi G., Poli G. (2012). Interaction between 24-hydroxycholesterol and amyloid-β in amplifying neuronal damage in Alzheimer disease. Oxidant and antioxidants in biology. Oxy- gen Club of California World Congress 2012, Alba (Cuneo), June 20-23, 2012.

Gamba P., Testa G., Guglielmotto M., Tamagno E., Gargiulo S., Sottero B., Poli G., Leonarduzzi G. (2011). Interazione tra ossisteroli e β-amiloide nella malattia di Alzheimer. Nuovi orientamenti della patologia molecolare - Riunione scientifica della Scuola Dianzani, Sassari, November 18-19, 2011.

Leonarduzzi G., Gamba P., Testa G., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Poli G. (2011). Interaction between 24-hydroxycholesterol and amyloid-β in amplifying neuronal damage in Alzheimer’s disease. Second International Conference on Enviromental Stressors in Biology and Medicine, Siena, October 5-7, 2011.

Leonarduzzi G., Gamba P., Testa G., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Poli G. (2011). Implication of oxysterols in the neuronal damage of Alzheimer’s disease. 1st ENOR Symposium on Oxysterols and Related Sterols in Chem- istry, Biology & Medicine, Roma, September 22-24, 2011.

Leonarduzzi G., Gamba P., Testa G., Gargiulo S., Maina M., Biasi F., Poli G. (2011). Cholesterol oxidation in the pathogenesis of human major chronic disease. SFRR- Europe 2011 Meeting, Instanbul (Turkey), September 7-10, 2011.

Leonarduzzi G., Biasi F., Gamba P., Gargiulo S., Mascia C., Testa G., Maina M., Poli G. (2011). Cholesterol oxidation products in the pathogenesis of human major chronic disease. International Symposium on Free Radical Research: Contribution to Medicine, Kyoto (Japan), January 20-22, 2011.

Testa G., Gamba P., Guglielmotto M., Tamagno E., Sottero B., Gargiulo S., Leonarduzzi G., Poli G. (2010). L’interazione tra 24-idrossicolesterolo e β-amiloide amplifica il danno neuronale nella malattia di Alzheimer. Aspetti molecolari del danno cellulare e tissutale - Riunione scientifica della Scuola Dianzani, Genova, December 3-4, 2010.

Maina M., Castello L., Testa G., Cavallini G., Biasi F., Leonarduzzi G., Donati A., Bergamini E., Poli G., Chiarpotto E. (2010). Il digiuno a giorni alterni modifica il fenotipo ipertrofico del miocardio nel ratto anziano agendo sulle vie di segnale ERK e PI3K. Aspetti molecolari del danno cellulare e tissutale - Riunione scientifica della Scuola Dianzani, Genova, December 3-4, 2010.

Maina M., Castello L., Testa G., Cavallini G., Bergamini E., Poli G., Chiarpotto E. (2010). Alternate-day fasting protects the rat heart against the age-related inflamma- tion and fibrosis. Lipid oxidation, human diseases and aging, Torino, June 16-18, 2010. Participation in national and regional projects

PRIN 2008: “Association between hepatocarcinogenesis and hypercholesterolemia:

role of signaling pathways that regulate cholesterol homeostasis and inflammatory re- sponse”. PRIN 2009: “Reactive oxygen species, cholesterol oxidation products and Azheimer's disease”. Awards RICERCA FINALIZZATA SANITARIA 2009: “Effect of cholesterol oxidation products on survival and death signals in the progression of neurodegenerative diseases.”

September 2008: “Vittorio Crescenzi” Grant from Fidia Farmaceutici S.p.A. for the best recent graduate in Chemistry at the Faculty of Mathematics, Physics and Natural Sci- ence of University ‘La Sapienza’, Rome.

/5 – Gabriella TESTA Curriculum vitae In compliance with the Italian legislative Decree no. 196 dated 30/06/2003, I hereby authorize you to use and process my personal details contained in this document.

Torino, 13 October 2014. Signature:

/5 – Gabriella TESTA Curriculum vitae