Supplemental Data s4

SUPPLEMENTAL DATA Supplemental Table S1 Chromosome Region (in kb) Known VDJ loci in region 1 51156 - 51229 Non-overlapping with KC-SMARTR 1 169933 - 169936 - 1 173069 - 173463 Non-overlapping with KC-SMARTR 2 88914 - 89282 Immunoglobulin (Ig) Kappa light chain 6 1754 - 1919 - 6 1923 - 2043 - 6 13394 - 13397 - 6 13400 - 13413 - 6 13599 - 13743 - 6 13814 - 13896 - 6 13972 - 14053 - 6 14099 - 14420 - 6 14423 - 14824 - 6 20345 - 20355 - 6 20525 - 20593 - 6 20707 - 22769 - 6 23172 - 23172 Non-overlapping with KC-SMARTR 6 24346 - 24357 Non-overlapping with KC-SMARTR 7 38261 - 38365 T-cell receptor Gamma 7 70059 - 70061 Non-overlapping with KC-SMARTR 7 141821 - 142204 T-cell receptor Beta 8 128836 - 128847 Non-overlapping with KC-SMARTR 12 9543 - 9607 Non-overlapping with KC-SMARTR 14 21439 - 22047 T-cell receptor Alpha 14 105290 - 105601 Ig heavy chain 14 105641 - 105854 Ig heavy chain 14 105867 - 105867 Ig heavy chain 14 105887 - 105943 Ig heavy chain 14 105994 - 106005 Non-overlapping with KC-SMARTR 14 106015 - 106105 Non-overlapping with KC-SMARTR 14 106204 - 106239 Non-overlapping with KC-SMARTR 14 106246 - 106251 Non-overlapping with KC-SMARTR 14 106269 - 106287 Non-overlapping with KC-SMARTR 14 106356 - 106356 Non-overlapping with KC-SMARTR 19 5461 - 5462 Non-overlapping with KC-SMARTR 22 21429 - 21552 Ig Lambda light chain

Supplemental Table S2

KC-SMARTR Segmented t-test Median sensitivity 91% 69% Median specificity 15% 31%