Table S5. Overlap of the Gene Lists for Contrasts. the Numbers Above the Diagonal Denote

Table S5. Overlap of the gene lists for contrasts. The numbers above the diagonal denote the overlapping genes between lists, below the diagonal are P-values, and at the diagonal is the number of unique genes in the lists. Genes responding to aging in control lines at day 19 (AC19) and 35 (AC35); genes responding to aging in longevity-selected lines at day 19 (ALS19), 35

(ALS35), and ≥ 60 (ALS60); genes responding to selection for increased longevity at the same chronological age at day 3 (Ch3),

19 (Ch19), and 35 (Ch35); genes responding to selection for increased longevity at the same physiological age at days 3-19 (P3),

19-35 (P19), and 35-60 (P35); the overlap between the genes responding to selection at the same chronological and physiological age (OL).

AC19 AL19 Ch3 P3 AC35 AL35 Ch19 P19 AL60 Ch35 P35 OL AC19 267 160 0 0 73 24 7 2 30 13 4 1 AL19 <0.0001 259 3 0 57 17 1 2 36 6 2 0 Ch3 NS NS 125 20 4 4 55 8 2 93 10 25 P3 NS NS <0.0001 23 0 0 17 8 1 15 8 20 AC35 <0.0001 <0.0001 NS NS 269 56 5 3 29 16 3 1 AL35 <0.0001 <0.0001 <0.01 NS <0.0001 88 3 4 14 3 2 0 Ch19 <0.01 NS <0.0001 <0.0001 <0.05 <0.01 99 12 3 77 13 28 P19 <0.05 <0.05 <0.0001 <0.0001 <0.01 <0.0001 <0.0001 38 0 13 15 17 AL60 <0.0001 <0.0001 NS NS <0.0001 <0.0001 NS NS 290 53 3 1 Ch35 NS NS <0.0001 <0.0001 <0.05 NS <0.0001 <0.0001 <0.0001 486 18 32 P35 <0.01 NS <0.0001 <0.0001 <0.05 <0.01 <0.0001 <0.0001 <0.05 <0.0001 50 22 OL NS NS <0.0001 <0.0001 NS NS <0.0001 <0.0001 NS <0.0001 <0.0001 40