Greater MAO-A Binding in Prefrontal and Anterior Cingulate Cortex in Postpartum Depression

Sacher et al.

Supplementary Section (S1)

Results

Additional Exploratory Analyses

Correlation of MAO-A VT in the Prefrontal and Anterior Cingulate Cortex with Symptom

Severity

To explore an alternative, symptom severity-oriented analysis, a regression was performed between the Hamilton Rating Scale for Depression and MAO-AVT values, and these were found

to be predictive of MAO-A VT in both the PFC ( = .443, t(54) = 3.63, p < .001) and ACC ( = .

373, t(54) = 2.96, p < .005.)

Correlations of MAO-A VT in the Prefrontal and Anterior Cingulate Cortex with Sex

Hormones

As the change in MAO-A level after estrogen decline has persistence beyond the duration in shift in estrogen, it seemed unlikely that there would be a correlation between MAO-A VT.

Nevertheless, levels of estradiol and progesterone were collected on the day of the [11C]harmine

PET scan (see Table 1) and the relation of these measures to PFC and ACC MAO-AV T was assessed in as an exploratory analysis. No correlation was found between plasma estradiol and

MAO-A VT (r = -0.158, p=.253 in the PFC and r = -0.074, p=.597 in the ACC) or between plasma progesterone and MAO-A VT (r = -0.017, p=.905 in the PFC and r = -0.084, p=.551 in the ACC).