CHEM 109. General, Organic, and Biological Chemistry for Nursing, 4T, 3 Credits

Spring, 2014 CHEM 109. General, Organic, and Biological Chemistry for Nursing, 4T, 3 credits Instructor: Dr. Mallory Cortez, Ph. D. Office: 133 Beauregard Phone: 985-448-4167 Email: [email protected] Course Meeting: 4T: Tues/Thurs 12 pm-1:20 pm Room: 104 Beauregard Office Hours: Mon/Wed 9:00 am -12:00 pm Tues/Thurs 9:00 am-11:00 am Fri By appointment only at least 2 days in advance Whenever I am in the office you are welcome to come in and ask questions. Course Description: Chem 109. General, Organic, and Biological Chemistry for Nursing . 3-3-0. Non- developmental Mathematics placement. General, Organic, and Biological Chemistry for Nursing will place an emphasis is on broad aspects of general, organic, and biochemistry necessary for the comprehension of biological processes occurring within the human body. A one-semester course designed for students in various health related programs – nursing, dietetics, etc. Degree credit will not be given for both CHEM 109 and 208, or 435. Basic computer knowledge is required for students enrolled in this course. (40.0599)

PREREQUISITES: Non-developmental mathematics placement

REQUIRED TEXTS AND OTHER MATERIALS: 1) General, Organic, and Biochemistry , 2nd edition by Frost, Deal, & Timberlake (ISBN 978-0-3219- 4506-8) or (ISBN 978-0-3218-0263-7) plus Mastering Chemistry 2) IClicker2

GENERAL EDUCATION STUDENT LEARNING OUTCOMES: CHEM 109, as a course specially designed for nursing students, fulfills three hours of general education requirements in the area of the natural sciences and is this designed to enable students to meet the following broad outcome for all natural sciences:

Goal: Upon completion of the undergraduate curriculum, students will be able to comprehend and to apply the basic principles of science and methods of scientific inquiry.

Students will be able to 1. Differentiate among facts, laws, theories, and hypotheses 2. Define major concepts, principles, and fundamental theories in at least one area of science 3. Demonstrate an understanding of the basic terminology in at least one area of science 4. Formulate a hypothesis, given a simple problem or questions, and design a valid experiment to test it 5. Make informed decisions on contemporary consumer or social issues demanding scientific literacy

For further explanation of the learning objectives associated with this goal, go to HtmlResAnchor http://www.nicholls.edu/gened/goals_objectives.html.

STUDENT OUTCOME OBJECTIVES: This one semester course is designed to introduce students to the general principles of chemistry geared to the allied health major including organic chemistry and biochemistry. The principles fall into the four main areas of: 1. Measurement and Mathematical Concepts (MMC) 2. Molecular Structures (MS) 3. Solution and Acid/Base Chemistry (ABC) 4. Biochemistry (BC) Upon successful completion of this course, the student should be able to:  Classify different forms of matter. Distinguish physical and chemical properties. Identify and describe the properties of metals and nonmetals (MS).  Measuring items and applying rules for significant figures correctly (MMC).  Convert English to metric units of measurement, and vice-versa. Perform simple dosage calculations through unit conversions (MMC).  Explain the basic relationships of gas pressure, temperature, volume, and amount. Apply Boyle’s Law and Charles’ Law (MMC).  Identify the number of subatomic particles present in atoms and ions. Distinguish between isotopes and ions by the number of subatomic particles present. Distinguish Mass Number from Atomic Mass (MS).  Identify specific charges on ions. Distinguish and name ionic and binary covalent compounds. Identify the number of valence electrons in the main group elements (MS).  Determine the molecular shapes of carbon, nitrogen, and oxygen in a covalent compound. Determine the polarity of the covalent bond and a covalent compound (MS).  Distinguish representatives of organic compounds (including Lewis, condensed, skeletal, 3-D ball, and stick structures). Define structural isomer (MS).  Recognize organic families and hydrocarbon functional groups (MS).  Distinguish isomers of organic compounds as structural, cis/trans, enatiomers, and diastereomers. Identify chiral centers in organic molecules (MS).  Identify a carbohydrate by its molecular formula and functional groups. Distinguish the simple sugars by structure and function (BC).  Determine the ring structure of a linear monosaccharide. Recognize and name a glycosidic linkage. Identify the products of the following reactions for carbohydrates: condensation, hydrolysis, oxidation and reduction. Describe what is a reducing sugar (BC).  Describe the structure and function of complex carbohydrates, and identify the corresponding glycosidic linkages (BC).  Draw fatty acid salts in water, a “micelle”. Describe the difference between a saturated versus an unsaturated fatty acid. Draw a triglyceride, and identify its functional groups. Distinguish between a fat and an oil.  Distinguish the structural differences between a triglyceride and a phospholipid. Identify the function of phospholipids. Draw a phospholipid bilayer (BC).  Determine the direction of the flow of water across a membrane in osmosis and diffusion (ABC). Distinguish the three main mechanisms of transport across a biological membrane (BC).  Distinguish between a solution and a suspension. Distinguish solutions as electrolyte, non- electrolyte, or weak electrolyte (ABC).  Calculate the concentration of a solution. Describe how you would make an aqueous solution of a known concentration using a solid solute or concentrated stock solution (ABC).  Identify and learn how to name the strong acids and bases. Identify an acid, base, conjugate acid and conjugate base. Write conjugate acid-base reactions. Write a balanced neutralization reaction (ABC).  Predict the strength of a weak acid from its Ka, or the pKa. Determine the acidity of a solution from the pH scale. Calculate the pH of a solution from its hydronium ion concentration and vice-versa (ABC).  Explain how buffering works, and the components that make up a buffer. Apply LeChatelier’s principle to the bicarbonate buffer system (ABC).  Determine the predominant species present in aqueous solution for the functional groups amine and carboxylic acid, found in amino acids, at a given pH (BC).  Draw the general structure of an amino acid in zwitterion form. Identify the functional groups: amide, thiol, aromatic, and disulfide. Classify the amino acids by R- group polarity and charge (BC).  Describe the levels of structure and various functions of proteins (BC).  Establish whether a chemical reaction is exothermic or endothermic, by using a reaction free energy diagram. Apply the factors that affect enzyme activity to a given situation. Distinguish between competitive and noncompetitive types of inhibition (BC).  Identify parts of a nucleotide and a nucleic acid. Distinguish purines and pyrimidines. Identify the structure and function of the nucleic acids DNA and RNA. Provide the complementary strand for a given strand of DNA showing the 5’ and 3’ ends (BC).

COURSE CONTENT: Chapter 1: Chemistry Basics-Matter and Measurement Chapter 2: Atoms and Radioactivity Chapter 3: Compounds-Putting Particles Together Chapter 4: Introduction to Organic Compounds Chapter 5: Chemical Reactions Chapter 6: Carbohydrates-Life’s Sweet Molecules Chapter 7: What’s the Attraction? State Changes, Solubility, and Lipids Chapter 8: Solution Chemistry-How Sweet Is Your Tea? Chapter 9: Acids, Bases, and Buffers in the Body Chapter 10: Proteins-Workers of the Cell Chapter 11: Nucleic Acids-Big Molecules with a Big Role Chapter 12: Food as Fuel-A Metabolic Overview

Homework: Homework will be given for each chapter on Mastering Chemistry. The due date will be two days after finishing the chapter. For full points, you must score at least 50% on the homework. It is your responsibility to make sure that you understand the homework. If you have problem doing the homework, please see me so that I can help you. No late homework will be accepted after the due date. The purpose of homework is to help you practice and prepare for the exam. The total points for each homework assignment will be 5 points.

Quizzes: Quizzes will be given in class with the iclicker2. Typically, a quiz will be given the next class period when a chapter is completed. The lowest two quiz grades will be dropped. The purpose of these quizzes is to keep students up to date on the materials as well as prepare students for the tests. No make-ups will be given for quizzes without an excuse. Make-ups must be taken within a day or two of the absence. Quizzes will be 10 pts each.

Bonus Points:  15 points will be given for attendance at the end of the semester. See details below under attendance. It is your responsibility that you sign the roll until the iclicker2 is populated, and to sign in with your iclicker2. I will not change attendance points if I do not have your signature or if you did not sign in with the iclicker2. If you do not bring your iclicker2 to class, you must sign a sheet of paper and turn it in to be by the end of class. I will only accept this form of sing in two times per student. (I will not accept emails, I must have your signature) I will not count an excused absence against you, but the excuse must be given to me by or before 1 week of the missed classed. I will not take excuses at the end of the semester.  Points will also be given with iclicker2 questions during the lecture. At the end of the semester, the number of points you received divided by the number of possible points. A score of 90% or greater will be worth 5 extra points, a score between 70-89% will be worth 4 points, a score between 50-69% will be worth 3 extra points, a score between 30-49% will be worth 2 points, a score between 15-29% will be worth 1 extra points, and a score of less than 25% will be worth 0 extra points. Iclicker2 bonus points cannot be made up for absences (even excused absences). Iclicker2 bonus points can also not be made up if you forget your iclicker as I go over the answers during class.  Tutorials and Practice Problems on Mastering Chemistry will also be available for bonus points. Each tutorial or set of problems will be worth a maximum of 1 extra point. For each tutorial or set of problems, a score of 80% or greater will be worth 1 extra point, a score between 65-79% will be worth 0.75 points, a score between 45-64% will be worth 0.5 extra points, a score between 20-44% will be worth 0.25 extra points, and a score of less than 20% will be worth 0 extra points. For each test, between 6 to 10 tutorial or set of problems will be available to students on Mastering Chemistry, so the bonus points can really add up.

Exams: 3 exams and 1 comprehensive Final exam will be given. I will drop your lowest exam grade (not including the Final). All students must take the Final. A tentative schedule for exams is listed at the end of this syllabus. These dates may change (with the exception of the final). I will announce all exams dates in class as well as post them on moodle. Notice that test will be worth 200 points and the Final 100 points, so the final can bring your grade up or bring it down. This means that the final can improve your grade, or bring your grade down.

Review Sessions: Review sessions will be given before every test to discuss problems and assignments. The time for these sessions will be announced.

Grading: The grading will be as follows. Homework and Quiz points are dependent on the amount of chapters covered during the class and are subject to change.

Item Total Points Homework 40 Quizzes 70 Exams 200 Final Exam 100 METHOD OF EVALUATION: The grades earned will be as follows 90%-100% A 80%-89% B 65%-79% C 55%-64% D

MAKE-UP POLICY: Make-up exams will be given for excused absences only. Homework assignments will not be accepted late.

ATTENDANCE POLICY: It is highly recommended that you attend class every day. Promptness is expected. I will give 15 points extra credit for attendance and participation. A student who misses 0 to 1 classes will earn 15 points, 2 to 4 classes will earn 10 points, 5 to 6 classes will earn 5 points, and missing 7 or more classes will result in no extra points. A sign in sheet will be available at the beginning of the class until the iclicker2 is populated, then the iclicker2 will be used for attendance. It is the student’s responsibility to sign in if they attended the class. If you do not bring your iclicker2 to class, you must sign a sheet of paper and turn it in to be by the end of class. I will only accept this form of sing in two times per student.

ACADEMIC HONESTY POLICY: Any student found cheating will be subject to the penalties as stated in the Student Code of Conduct handbook; including but not limited to a score of zero on exam, expulsion from the class or expulsion from the University.

SEMESTER WITHDRAWALS: The last day to withdraw from the class with a “W” is March 28th 2014.

ACADEMIC DISABILITIES POLICY: If you have a documented disability that requires assistance, you will need to register with the Office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

CLASS DISRUPTIONS: Are not tolerated. The use of cell phones, pager and/or any other electronic personal devise in class is prohibited. Any infractions will result in the dismissal from class.

ACADEMIC GRIEVANCES: The proper procedure for filing grade appeals or grievances related to academic matters is listed in Section 5 of the Code of Student Conduct and at the following link: http://www.nicholls.edu/documents/student_life/code_of_conduct.pdf. ASSISTANCE WITH STUDYING AND ASSIGMENTS The Tutoring Center at 143 Peltier Hall. Call 985-448-4100, email: [email protected], or visit http://www.nicholls.edu/academic-enhancement/ The Writing Center at 144 Peltier Hall. Call 985-448-4100, email: [email protected], or visit http://www.nicholls.edu/academic-enhancement/ Online Tutoring through Moodle. Look for the Brainfuse log-in link on the home page,http://moodle2.nicholls.edu/moodle/

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for:  Reading regular emergency notifications on the NSU website;  Knowing how to use and access Blackboard/moodle;  Being familiar with emergency guidelines;  Evacuating textbooks and other course materials;  Knowing their moodle student login and password;  Contacting faculty regarding their intentions for completing the course.

Faculty are responsible for:  The development in the use of the moodle software;  Having a plan for continuing their courses using only Blackboard and email;  Continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses;  Making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like only in the immediate semester following the emergency.

Note: This is not a binding contract. This syllabus is subject to change throughout the course. Tentative Schedule*: Date Topic Date Topic Jan. 21 University Closed Jan. 23 Introduction Begin Ch. 1

Jan. 28 Ch. 1 continued Jan. 30 Quiz 1 Ch. 2 Feb. 4 Ch. 2 Continued Feb. 6 Quiz 2 Ch. 3 Ch. 3 continued Feb. 11 Quiz 3 Feb. 13 Exam 1 Review for Exam 1 Feb. 18 Ch. 4 Feb. 20 Ch. 4 Continued

Feb. 25 Ch. 4 Continued Feb. 27 Quiz 4 Ch. 5 March 4 Mardi Gras Holiday March 6 Ch. 5 Continued

March 11 Quiz 5 March Ch. 6 Continued Ch. 6 13

March 18 Quiz 6 March EXAM 3 Review For Exam 3 20 Chapters 4,5, and 6 March 25 Ch. 7 March Ch. 7 Continued 27 April 1 Quiz 7 April 3 Ch. 8 Continued Ch. 8 April 8 Quiz 8 April 10 Ch. 9 Continued Ch. 9 April 15 Quiz 9 April 17 Exam 3 Review Exam 3 April 22 Spring Break April 24 Spring Break

April 29 Ch. 10 May 1 Quiz 10 CH. 11 May 6 Last day of class May 8 No class, finals Review for Final May 13 Final Chem 109-4T May 15 May 16 1pm-3pm (THURSDAY) Grades Due 9:00 am

*We may not follow this tentative schedule exactly as written.