Model I: Clinical Risk Factors

Supplementary Table 7. Multivariate Analysis of Prognostic Factors for Progression Free Survival and overall survival in NSCLC patients under 65 years old (n=108)

Progression Free Survival Model 1 Model 2 Model 3 P Variables HR(95% CI) HR(95% CI) P value HR(95% CI) P value value CCRTx 2.32 (0.66-8.07) 0.19 2.36 (0.7-7.94) 0.17 2.23 (0.62-7.96) 0.22 Operation 0.61 (0.25-1.45) 0.26 0.78 (0.31-1.96) 0.6 0.52 (0.2-1.38) 0.19 TNM stage

I ref 0.01 ref 0.01 ref 0.01 II 1.59 (0.32-7.83) 0.57 1.54 (0.32-7.33) 0.59 1.85 (0.37-9.3) 0.46 III 3.01 (0.77-11.8) 0.11 3.2 (0.85-12.06) 0.09 2.88 (0.73-11.41) 0.13 <0.001 <0.001 <0.001 IV 9.66 (2.38-39.17) 9.22 (2.34-36.4) 10.26 (2.38-44.2) S-CYFRA 1.97 (0.95-4.06) 0.07 (≥3.30) S-CEA (≥5) 1.11 (0.56-2.18) 0.77 S-SCCA (≥2) 1.06 (0.34-3.29) 0.91 C-CYFRA (≥53.3) C- 0.57 (0.26-1.22) 0.14 CEA(≥38.80) C- 1.29 (0.57-2.93) 0.54 SCCA(≥0.44) 1.35 (0.74-2.49) 0.33

Overall Survival Model 1 Model 2 Model 3 P Variables HR(95% CI) HR(95% CI) P value HR(95% CI) P value value <0.001 Male 5.16 (1.67-15.92) 4.72 (1.39-16.1) 0.01 2.24 (1.2-4.19) 0.01 CCRTx 1.25 (0.17-8.95) 0.83 1.5 (0.2-11.53) 0.69 0.47 (0.27-0.81) 0.01 Operation 0.18 (0.04-0.92) 0.04 0.24 (0.04-1.34) 0.1 0.34 (0.15-0.76) 0.01 Stage <0.001 <0.001 I ref 0.04 ref 0.06 ref <0.001 II 3.98 (0.24-66.39) 0.34 1.3 (0.09-18.2) 0.85 9.71 (3.18-29.7) III 1.31 (0.09-18.16) 0.84 14.09 (1.47-135) 0.02 3.87 (1.33-11.3) 0.01 <0.001 IV 14.16 (1.67-120) 0.02 1.69 (0.59-4.81) 0.33 8.05 (2.91-22.3) S-CYFRA 0.7 (0.27-1.83) 0.46 (≥3.30) S-CEA (≥5) 0.69 (0.2-2.34) 0.55 S-SCCA (≥2) 3.82 (0.23-64.2) 0.35 C-CYFRA 0.92 (0.54-1.59) 0.77 (≥53.3) C-CEA(≥38.80) 1.06 (0.46-2.43) 0.89 C-SCCA(≥0.44) 1.94 (1.06-3.55) 0.03 * units for tumor markers are in ng/ml

Model I: clinical risk factors. Model II: clinical risk factors + serum tumor markers Model III: clinical risk factors + cytologic tumor markers