HUMAN HEALTH/QUANTATIVE RISK ASSESSMENT NJIT DEPARTMENT CHEMISTRY AND ENVIRONMENTAL SCIENCES ADJUNCT PROFESSOR: JOHN S. DOBI, Ph.D. 973 430 8036

[email protected] [email protected]

FALL SEMESTER 2014 Faculty 321 WEDNESDAY 6-9

OBJECTIVES: A. TO DEVELOP AN UNDERSTANDING OF THE REGULATORY AND SCIENTIFIC CONCEPTS, QUANTIFICATION PROCEEDURES REQUIRED FOR THE HUMAN HEALTH RISK ASSESSMENT. B. TO ENABLE STUDENTS TO PERFORM AND CRITICALLY ANALYZE RISK ASSESSMENTS.

CLASS TOPIC OF LECTURE/ DISCUSSION

Sep 03 Course Objectives, Overview of the Risk Assessment Process, Interdisciplinary Science Prerequisites. Sep 10 Environmental Chemistry, Biochemistry, Toxicology, Statistics and Environmental Regulations, (CERCLA/SARA RI/FS). Sep 17 Assessment Concepts, Techniques/ Applications- Data usability/ Modeling. Sep 24 Site Characterization, Field Protocols, Data Requirements and Integration for Risk Analysis. EPA use of new cancer guidelines. Oct 01 Chemicals of human health Concern- Identification and Qualifiers. Oct 08 Exposure Assessments/ Pathways- Fate and Transport Models. Oct 15 Toxicity Assessments – Monte Carlo and Toxicity Models. Oct 22 MIDTERM EXAM- TAKE HOME. Risk Characterization/ Risk Management. Oct 29 Critical evaluation of Statistics and modifying factors. Nov 05 Uncertainty Analysis in Risk Assessment. EPA Risk Based Screening Tables. Nov 12 Human Health and ingestions of contaminated food sources. Nov 19 Biomagnification of carcinogens. – mutagens and teratogens Nov 26 How safe is our food source and the time to tumor estimates Dec 03 Applied Risk Assessments/ Case Studies. TAKE HOME FINAL EXAM. Dec 10 Case Studies- Examples of Risk Assessment- Retrospective Assessments.

TEXTBOOKS 1. Risk Assessment Guidance for Superfund. Volume I -Human Health Evaluation Manual (Part A) EPA 540- 1-89-002 December 1989. 2. Handouts - Ecological Risk Component

Grade: 25% Class participation. 25% Midterm. 50% Final.