Research Awards, Honours and Major Stipendiary Support

CURRICULUM VITAE FULL NAMES KONTTINEN, Yrjö Tapio DATE AND PLACE OF BIRTH Helsinki, 28th Sept 1952 Married to Margaretha Segerberg. Children Liisa FAMILY Marianne Veronica Konttinen 210278 and Yrjö Lars Kristian Konttinen 040582 CURRENT POSITION Consultant in Rheumatology, Department of Medicine, HYKS 1989- Head, Musculoskeletal Diseases and Inflammation Research Group, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland 1980- Head, Musculoskeletal Diseases and Inflammation Research Group and Cell and Molecular Biology Laboratory, Institute of Biomedicine, Department of Anatomy, Helsinki University, Helsinki, Finland 1991- Head, Experimental Research, ORTON Research Institute, Invalid Foundation, Helsinki, Finland 1994-

CONTACT INFORMATION Division of Rheumatic Diseases, Department of Medicine Helsinki University Central Hospital/ Surgical Hospital Kasarmikatu 11-13, 00130 Helsinki, Finland Tel: +358-9-1918576 (answering service) Fax: +358-9-1918499 E-mail: [email protected] (also: [email protected])

EDUCATION AND TRAINING High School Graduation, Helsingin suomalainen normaalilyseo May 1971 Licentiate of Medicine, University of Helsinki and University of Uppsala 2 Aug 1977 Dissertation (PhD), University of Helsinki 12 May 1981 Specialist in Internal Medicine 31 Oct 1984 Subspecialist in Rheumatology 2 Jun 1986 Docent in Experimental Medicine, University of Helsinki 10 Jan 1986 Docent in Internal Medicine, University of Helsinki 21 March 1989 1990, Competence to Professor and Head of Division of Rheumatology, Akademiska 1991, Sjukhuset, Uppsala, Karolinska Institutet, Stockholm, Sahlgrenska Sjukhuset, Göteborg, 1996, 1997 University of Lund, Lund, Sweden Competence to Associate Professor/ Full Professor and Head of Department of Internal 1989, 1990, Medicine, Helsinki University Central Hospital, Helsinki, Finland 1997

PREVIOUS PROFESSIONAL APPOINTMENTS 2

House officer (Helsinki University Central Hospital, Finland; Umeå University Central 1974-1981 Hospital, Sweden; Göttingen University Central Hospital, West-Germany; Åland Central Hospital, Åland; Rigshospitalet in Copenhagen, Denmark), total 47 months General Practioner, Östra Nylands Muncipal Health Centre, total 7 months 1977-1978 Acting House Officer and Specialist, Anesthesiology, Helsinki University Central Hospital 1981-1984 and Jorvi Hospital, total 6 months Rheumatology Fellow, Helsinki University Central Hospital, total 13 months 1985-1986 Acting Hospital Physician and Specialist, Helsinki University Central Hospital, Internal 1981 Medicine, 3 1/2 months Acting Hospital Physician and Specialist, Helsinki University Central Hospital, Rheuma- 1981-1982 tology, total 4 1/2 months Acting Senior Physician, Rheumatology, total 9 1/2 months 1986-1987 Consultant Rheumatologist, Helsinki (University Central Hospital) 1989-

RESEARCH AWARDS, HONOURS AND MAJOR STIPENDIARY SUPPORT Scandinavian Rheumatology Award Winner Researcher, total 5 months 1980 Junior Research Fellow, Helsinki University, total 17 months 1981-1985 1986-1988 Senior Research Fellow of the Arthritis Foundation in Finland, Helsinki University Central Hospital, total 22 months Acting Senior Research Fellow of the Finnish Academy, total 4 months 1988

Aug 1989-Aug Senior Research Fellow of the Finnish Acedemy, a 3-year tenure 1992 Senior Clinical Research Fellow of the Finnish Academy, a 3-year tenure Jan 1994-Dec 1996 3

STIPENDIARY SUPPORT: DURING THE LAST THREE YEARS AND PRESENTLY RUNNING (Institutional support for reagents and equipment is not included) Finnish Academy, Diamond coated hip implants, 1995-1997, 1 600 000 mk HYKS evoproject TYH 0068, Sjögren’s syndrome, 1997-1998, 400 000 mk HYKS evoproject TYH 0056, Total hip replacement, 1997-1999, 1 040 000 mk HYKS evoproject TYH 8307, Bisphosphonates in arthritis, 1998-2000, 600 000 mk HYKS evoproject TYH 0056, Mcp joint replacements in RA, 1998-2000, 100 000 mk OPM (Opetusministeriö/ Ministry of Education): Graduate School in Medicine, 3-4 yrs salary to Dr Solovieva (PhD student) Sigrid Juselius Foundation, Biocompatibility, 1997-1998, 120 000 mk (new application pending) Lääkelaitos (Food and Drug Administration/ Medical Devices), Surgibone/ xenografts, 1997-1998, 72 000 mk Lääkelaitos (Food and Drug Administration/ Medical Devices), Biomaterials, 1998-2000, 880 000 mk (1998-2000; a joint project with BioCity from Turku and FinnMedi from Tampere) In addition, support is/ has been received from other sources, such as Reumatautien tutkimussäätiö, Suomen Ortopedian ja Traumatologian Säätiö, Signe ja Ane Gyllenbergin Säätiö, Orion, Leiras, Duodecim, Suomen Lääketieteen säätiö, Paulon Säätiö, CIMO (Center for International Mobility), NorFA (Nordic Research Academy), EU (Sjögren’s Syndrome Task Fource). Industrial support at the present from the following companies: Hoechst, Schering/Leiras, MSD, Roche, Searle

STUDIES ABROAD 1982-1984 International Research Fellow, University of California San Diego, funded by NIH Fogarty Center, total 19 months (Professor Nathan J. Zvaifler and Professor Harry G. Bluestein, UCSD, 225 Dickinson Str, San Diego, CA 92103)(articles published: A33, A40, B17) Visiting Professor, Institute of Molecular Immunology, Hospital for Joint Diseases, NYU Aug 1989-June Medical School, 301 East 17 Street, New York, NY 10003, August 1989 - June 1991 1991 (Professor Robert J. Winchester), total 22 months (A141, A142, A143, A144, A151, A152, A153, A154, A155, A159, A160, A161, A164, A165, A166, A168, A169, A171, A174, A176, A177, A178, A180, A181, B41, B43, B45, B47, B50, B51, B52, B72) Visiting Professor, Division of Autoimmune and Molecular Diseases, Department of July 1991-Sept Pediatrics, College of Physicians & Surgeons, 630 W. 168th Street, New York, NY 1991 10032, total 3 months (B54, B70) Visiting Professor, Rheumatology / Clinical Immunology, 562 Heritage Medical April 1993-June Research Center, University of Alberta, Edmonton, Alberta T6G 2S2, Canada (A201, 1993 A210, A211, A217, B48, B56, B76, B81) 4

Visiting Scientist, Laboratoire d'Histodynamique Osseuse, Université Claude-Bernard, June 1995 Faculté de Médecine Alexis Carrel, Rue Guillaume Paradin, 69372 Lyon Cedex 8 and Hôpital Edouard Herriot, Pavillon F, 69437 Lyon Cedex 3, France

EDITORIAL BOARD MEMBERSHIPS Scandinavian Journal of Rheumatology, Scientific Advisory Board 1987- Scandinavian Journal of Rheumatology, Deputy Editor, Finland, Editorial Board 1995- Rheumatology in Europe (formerly EULAR Bulletin), Finnish Member of the Editorial 1987- Board 1990 Inflammacion, International Editorial Board Finnish Dental Society, Corresponding Member 1992- SPINE, Advisory Board Member 1994- Clinical and Experimental Rheumatology, Editorial Board 1998-

MEMBERSHIP IN SCIENTIFIC SOCIETIES Duodecim (Finnish College of Physicians) 1971- Finnish Medical Association 1977-1990 Finska Läkaresällskapet 1979- 1979-1994 Histochemical Society (Finland) Finnish Society for Rheumatology (Board Member) 1979-Finnish Society for Internal Medicine 1979- Scandinavian Society for Immunology 1980-1994 Histochemical Society (American) 1980- Helsingin yliopiston dosenttiyhdistys 1986-1990 American College of Rheumatology (ACR, former American Rheumatism Association) 1988- International Society for the Study of the Lumbar Spine 1991- Scandinavian Society for Orthopaedics 1993- 1994- Anatomici Fenniae The New York Academy of Sciences 1995- The Finnish Musculoskeletal Diseases and Inflammation Research 1997- Society (Vice Chairman) International Association for the Study of Pain (IASP) 1998-

OTHER ACADEMIC AND PROFESSIONAL ACTIVITIES Opponent for 3 doctoral dissertations (Jyrki Heino, 1987, University of Turku, Finland; Kari Pulkki, 1988, University of Turku, Finland; Elisabet Josefsson, 1995, University of Göteborg, Sweden) Faculty appointed expert 1) for 5 doctoral dissertations (Dr Aki Hietaharju, 1993, University of Tampere, 5

Finland; Laura Pirilä, 1997, University of Turku, Finland; Dr Anne Roivainen, 1997, University of Turku, Finland; Dr Thua Österman, 1997, University of Turku, Finland; Dr Meeri Sutinen, 1998, University of Oulu, Finland) and 2) for Dr Robert von Essen for his docent title in Rheumaimmunology at Tampere University, Finland, 1993 I have been a supervisor for the following 18 completed doctoral dissertations [References after the thesis refer to the list of original publications of this supervisor. Cosupervisor(s) are also given in parenthesis] Ville Bergroth, 1983: Immunoperoxidase and related techniques. Evaluation of methodology and application to quantitative kinetic studies of immunocompetent cells. University of Helsinki. (A6, A19, A23, A24, A26; Sakari Reitamo) Anu Kilpi (os Seppä), 1987: Characterization of mononuclear cells of inflammatory infiltrates in oral tissues. A histochemical and immunohistochemical study of labial salivary glands in Sjögren's syndrome and of oral lesions in systemic lupus erythematosus and in lichen planus. University of Helsinki. (A18, A25, A27, A28, A30; Maria Malmström). Dan Nordström, 1989: Cellular inflammation in arthritis. A study of clinical, histological and immunological aspects in rheumatoid and reactive arthritis. University of Helsinki. (A36, A38, A42, A51, A80; Claes Friman) Margaretha Segerberg, 1989: The diagnosis of Sjögren's syndrome. Histopathological and immunological studies. University of Helsinki. (A43, A52, A65, A74, A86; Maria Malmström) Peter Jungell, 1989: Oral lichen planus. An ultrastructural and immunohistochemical study. University of Helsinki. (A57, A58, A61, A88, A105; Maria Malmström) Riitta-Mari Tulamo, 1991: Changes in equine synovial fluid with special reference to intra-articular infection, corticosteroid injection, and hyaluronate concentration. College of Veterinary Medicine, Helsinki. (A98, A113; Ilkka Alitalo) Visa Honkanen, 1992: Nutritional factors in rheumatoid inflammation. A study on certain nutrients with possible antioxidative or anti-inflammatory potential in patients with juvenile chronic arthritis or rheumatoid arthritis. University of Helsinki, Finland. (A81, A101, A147, A157; Pirkko Pelkonen) Markku Kauppi, 1992: Rheumatoid cervical spine - a clinical, radiological and pathophysiological study. University of Tampere, Finland. (A83, A90, A108, A110, A139, A143) Pekka Nykänen, 1992: Cell proliferation in rheumatoid arthritis synovial membrane and synovial fluid. University of Helsinki, Finland. (A34, A35, A45; Otto Wegelius) Herkko Saari, 1992: Reactive oxygen species as mediators of tissue destruction events in inflammatory joint diseases. University of Helsinki, Finland. (A75, A93, A122, A141, A148) Ritva Häyrinen-Immonen, 1993: Recurrent aphthous ulcers. The inflammatory process. An immunohistochemical study. University of Helsinki, Finland. (A159, A173, A179, A184; Maria Malmström) Tuula Ingman, 1994: Matrix metalloproteinases and endogenous inhibitors in periodontal disease. University of Helsinki, Finland. (A172, A192, A196, A201, A213, A214; Timo Sorsa) Mika Hukkanen, 1994: Neuropeptides in the central and peripheral nervous system: Their role in the pathophysiology of painful osteoarticular inflammatory disease and trauma in man and animals. University of 6

London, UK (A87, A96, A102, A127, A132, A133, A152, A153, A154, A162, A164, A166, A173, A176, A178, A181, A182, A186, A188, A189, A198, A205, A209, A215; Julia M. Polak) Antti Sukura, 1995: Pneumocystis carinii in a rat model. (Together with Prof Lars-Axel Lindberg, Veterinary College of Medicine and Prof Ewert Linder, The Swedish Institute for Infectious Disease Control, Stockholm, Sweden). College of Veterinary Medicine, Helsinki, Finland (A231, A235; Lars-Axel Lindberg, Ewert Linder) Jyrki Törnwall, 1996: Neuropeptides in Sjögren's syndrome. University of Helsinki, Finland (A195, A197, A198, A245, A246, A265; Hannu Uusitalo) Michiaki Takagi, 1996: Biocompatibility. University of Helsinki, Finland. (A170, A207, A210, A217, A223, A229, A237, A238, A240, A248, A260; Seppo Santavirta; Accepted with Honours by the Faculty of Medicine, University of Helsinki) Nina Santavirta, 1997: Coping in chronic musculoskeletal diseases. Karolinska Institutet, Stockholm, Sweden. (A119, A140, A200, A246, A249, A251, A255; Hjördis Björvell) Ruth Sepper, 1997: Inflammation and proteolysis in bronchiectases. University of Helsinki, Finland (A218, A221, A222, A252, A268; Timo Sorsa).

Thesis works currently supervised: Anu Kilpi: Inflammation in oral lichen planus. University of Melbourne, Australia. (External supervisor) (A236, A273; Peter C. Reade, Alison Rich); now being examined by the Faculty pointed Examiners Olli Teronen: Proteolytic enzymes in jaw cysts. University of Helsinki, Finland. (A225, A227, A228, A254, A274, A281; Timo Sorsa); now being examined by the Faculty pointed Examiners Yanli Ding: Proto-oncogens in periodontitis. University of Helsinki, Finland (A183, A224, A258, A259, A274; Timo Sorsa, Markus Haapasalo); now being examined by the Faculty pointed Examiners Arnoldas  eponis: Cellular and molecular events in acute arthritides. University of Helsinki, Finland (A243, A264, A271, A276, A306, A317; Seppo Santavirta) Otso Lindy: Matrix metalloproteinases in arthritis. University of Helsinki, Finland (together with Dr Timo Sorsa) (A129, A151, A234, A292) Hannele Koski: Cytokines in Sjögren's syndrome. University of Helsinki, Finland. (A239, A279, 329; Timo Sorsa) Taina Tervahartiala: Proteolytic enzymes in periodontitis. University of Helsinki, Finland. (A203, A232; Timo Sorsa) Jing-Wen Xu: Osteoclast activating cytokines in loosening of totally replaced hips. University of Helsinki and University of Kuopio, Finland (A264, A267, A275, A276, A277, A278, A298, A302, A303, A306, A316, A321, A326; Seppo Santavirta). Sirajedin Natah: Recurrent aphthous ulcers. University of Helsinki, Finland (A267, A287, A291, A323; Maria Malmström, Jarkko Hietanen) Ville Waris: Biocompatibility of hip implants, to be registered at the University of Helsinki, Finland (A275, A277, A278, A298, A316; Seppo Santavirta) 7

Jere Linden: Matrix metalloproteinases in adjuvant induced arthritis in rats: expression in normal and arthritic joints and effect of inhibition on the course of arthritis (Veterinary School of Medicine, University of Helsinki) Oliver Michelsson: Extracellular matrix macromolecules as mediators and targets for osseointegration and loosening, respectively, of total joint replacements (A303, Seppo Santavirta) Risto Kontio: Inflammatory cells and extracellular matrix around mandibular bone implants (A326, Ismo Virtanen, Christian Lindqvist)

Post-doctoral fellows & other visitors Past: Mitsuru Sakaguchi ( University of Kumamoto, Japan; A83, A90, A110, A139, A289, D8) Orhan Güven ( University of Ankara, Turkey; A118) Katalin Szocsik ( Semmelweis University, Hungary; A94) Tomoyuki Saito (Yokohama City University, Japan, A120, B32) Xuhong Gu (from: London University, UK; A188, A239) Michiaki Takagi (from: Yamagata University, Japan; A206, A207, A210, A217, A223, A229, A237, A238, B59, B68, B80, D47, D48, D49) Ryoko Takagi (from: Yamagata Univeristy, Japan; C199, C212, D48) Karin Ganlöv (from: Malmö University, Sweden; A242, NorFA project) Anna-Karina Smidt (from: Malmö University, Sweden; NorFA project) Yutaka Nasu (from: Shinshu University, Japan; A226, B58) Jirong Jin (from: Shanghai, China; A 240; B56) Laila Buø (from: Rigshospitalet, Oslo, Norway; A229, A238, A252, A261, A327) Nikita P. Williams (from: Winston Salem State University, North Carolina, USA; A286) Shinji Imai (from: Shiga University, Japan; A293, A295, A296, A301, A302, A303, A312, B99, B100, B102) Ruth Sepper (from: Tartu University, Estonia; A218, A221, A222, A224, A231, A235, A241, A252, A268) Kaiu Prikk (from: Tartu University, Estonia; A283) Vedran Stefanovic (from: Zagreb University, Croatia; A300) Pavel Horak (from: Olomouc University, Czech Republic; B109) Joy Whittington (Medgar Evers College, Brooklyn, New York, USA)

Present: 1) Yanli Ding (from: Beijing Medical University, P.R. of China; A183, A203, A222, A224, A228, A232, A233, A253, A258, A259, A274, A280, A281, A292, A299, A318; B79, B82) 2) Arnoldas eponis (from: State Institute of Experimental and Clinical Medicine, Vilnius, Lithuania; A237, A240, A241, A243, A264, A267, A271, A276, A292, A302, A306, A312, A317, A321, B100) 3) Svetlana Solovieva (from: University of St. Petersburg, Russia; A237, A240, A241, A243, A249, A251, A255, A263, A267, A269, A314) 4) Jing-Wen Xu (from: Wuhu Anhui, P.R. of China; A264, A267, A275, A276, A277, A278, A298, A302, 8

A303, A306, A316, A321, A326, B100, B102, B104) 5) Anu Kilpi (from: University of Melbourne, Australia; Australian citizen; A236, A273, A288, A325) 6) Tiang Fang Li (from: Beijing Medical University, P.R. of China; A298, A302, A303, A313, A326, B100, B102, B108) 7) Sirajedin S. Natah (from: Al-Fateh University, Libya; A264) 8) Jumang Hao (from: P.R. of China)

Supervisor of 10 week research projects for the following medical students: Riikka Tulensalo: Hyaluronate in arthritis. Tora Bäckström: Anesthesia of the rheumatoid cervical spine patients. Minna Konttinen: Hyaluronate in juvenile chronic arthritis. Otso Lindy: Regulation of the oxidative activation of human neutrophil collagenase. Hannele Koski: Gelatinase and collagenase in periodontitis. Juha Pettilä: Tetracyclines in the treatment of recurrent aphthous ulcers. (Awarded for Excellence by the Faculty of Medicine, University of Helsinki)

Member of EULAR (European League Against Rheumatism) Publication Committee 1987-1989 The Finnish-Soviet Union joint commission for co-operation in medicine, the Finnish leader of the theme "Sjögren's syndrome" 1986-1990 European Study Group on Sjögren's syndrome, Finnish leader for EEC-Comac study on Criteria for Sjögren's syndrome. 1988- Secretary, Finnish Society for Rheumatology, 1987-1989 Scientific Secretary for the XXIIIth Scandinavian Congress of Rheumatology (13.-16.6.1990, Tampere, Finland) XIIth European Congress of Rheumatology (30.6.-6.7.1991, Budapest, Hungary), Member of the International Scientific Advisory Committee Sixth International Seminar on the Treatment of Rheumatic Diseases (13.12.-19.12.1992, Tel Aviv, Israel), Member of the International Board Scientific Secretary for the Scandinavian Congress of Rheumatology, year 2000, Turku, Finland The First International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases (18.09.- 20.09.1998, Genova, Italy), Member of the Scientific Committee

Supplement Editor: Etiopathogenesis of rheumatoid arthritis. Scand J Rheumatol Suppl 74, 1988 Supplement Editor (together with von Essen R, Hämäläinen M, Isomäki H): Abstracts of the XXIII Scandinavian Congress of Rheumatology, Tampere, June 13-16, 1990. Editor (together with Santavirta S): The Rheumatoid Cervical Spine, Finnish Orthopaedic Association, 129 p, 1994 9

Price for "SLE patient education" from the Finnish Rheumatism Association (Patient Organization Reumaliitto), 1995 Price for Excellence in Rheumatological Research, Arthritis Foundation (Research Foundation, Finland), 1995 Rheumatology Lecture of the Year 1996, Finnish Society for Rheumatology, Annual Meeting, Helsinki, Finland, 1996

Reviewer for the following journals: Histochemistry, Journal of Histochemistry and Cytochemistry, Scandinavian Journal of Rheumatology, Acta Orthopaedica Scandinavica, Annales Chirurgiae et Gynaecologiae, Acta Microbiologica Pathologica and Immunologica Scandinavica, Rheumatology International, Annals of the Rheumatic Diseases, Clinical and Experimental Rheumatology, Journal of Rheumatology, Arthritis and Rheumatism, Spine, Journal of Orthopaedic Research, Clin Chim Acta, Eur J Clin Chem Clin Biochem, The Lancet

Grant and conference reviews for: Arthritis and Rheumatism Council (UK); The Wellcome Trust (UK); New York Academy of Sciences (USA); European Science Foundation, Strasbourgh (France); Center for International Mobility, University of Helsinki (Finland)

INVITED LECTURES AND CHAIRMANSHIPS ABROAD: for other lectures, including those given at international meetings arranged in Finland, see a separate list 1979 Astra-Syntex Scandinavian Rheumatology Prize, "Immunocompetent cells in rheumatoid arthritis". Wiesbaden, FRG, 03.09.1979 1985 Symposium on bone, joint and muscle diseases. Background, diagnostics and treatment, "The inflammatory reaction: cellular aspects". Copenhagen, Denmark, 08.02-10.02.1985 1985 7th European Immunilogy meeting, Jerusalem, Workshop chairman: Immunology of viruses + presentation on "Killer cell mediated control of EBV transformed B cells". Jerusalem, Israel, 08.09-13.09.1985 1985 Finnish-Soviet Symposium on Seronegative Arthritis, "An active, but normally down-regulated cell- mediated immune response in the diseased joints in reactive arthritis". Suzdal, USSR, 01.10- 05.10.1985 1986 Finnish-Soviet Symposium on connective tissue diseases, "Sjögren's syndrome". Moscow, USSR, 16.03-22.03.1986 1986 The First International Seminar on Sjögren's syndrome-1986, Copenhagen, "Lymphocyte activation in the minor salivary glands of patients with Sjögren's syndrome". Holte, Denmark, 08.05.-11.05.1986 1986 Fourth International Seminar on the Treatment of Rheumatic Diseases, "Rheumatoid cervical spine". Jerusalem, Israel, 02.11.-09.11.1986 1986 Fourth International Seminar on the Treatment of Rheumatic Diseases, "Epstein-Barr virus and 10

rheumatoid arthritis". Jerusalem, Israel, 02.11.-09.11.1986 1987 XIth European Rheumatology Congress, Round Table on "Sjögren's syndrome: a model for autoimmunity and malignancy", "Immnopathologic and histologic findings in Sjögren's syndrome". Athens, Greece, 29.06.1987 1987 Meeting of the Secretaries of the Nordic Rheumatological Societies. Chaiman + presentation on "The Finnish Society of Rheumatology". Athens, Greece, 30.06.1987 1987 Presentation of the research work of the rheumatoid research group at the IV Department of Medicine. Uppsala, Sweden, 20.11.1987 1988 Scandinavian Congress of Rheumatology, Plenary lession: "The Theoretical Basis for the Use of Remitting Agents in Rheumatoid Arthritis". Reykjavik, Iceland, 31.05.-03.06.1988 1988 The First International Conference on Synovitis. Characteristics and functions of synovial cells, Plenary lession: "Synovial fibroblasts". Oslo, Norway, 09.06.-12.06.1988 1988 The London Hospital Medical College (Chief Professor DR Blake) "In situ hybridisation in the study of rheumatic diseases". London, UK, 20.09.1988 1988 Workshop on Diagnostic Criteria for Sjögren's syndrome. "Oral parameters in the diagnosis of Sjögren's syndrome". Pisa, Italy, 30.09.-01.10.1988 1988 2nd International Synposium on Sjögren's syndrome, "Localization of lysozyme mRNA in the labial salivary glands by in situ hybridization in Sjögren's syndrome". Austin, Texas, 23.10.- 25.10.1988 1988 All-Union Conference "Local therapy of rheumatic disorders" dedicated to the 60th Anniversary of AUSSR and to the 30th Anniversary of the Institute of Rheumatology of the USSR Academy of Medical Sciences. "Synovial fibroblasts in rheumatoid arthritis". Plenary lecture. Moscow, USSR, 07.12.1988 1988 All-Union Conference "Local therapy of rheumatic disorders", see above. Chairman of the final plenary session. Moscow, USSR, 07.12.1988 1989 Romazarit consultant meeting. Discussion of the protocol. Zurich, Switzerland, 19.01.-20.01.1989 1989 Pain in Osteoarthritis, International Medical Conference, "Immunostaining of Pain Fibers in Osteoarthritis". Sponsored by the University of Miami School of Medicine, Chairman Roy D. Altman, Cancun, Mexico, 01.02.-05.02.1989 1989 Regionsjukhuset i Umeå, Reumatologiska kliniken. "Neuropeptider vid artrit". Umeå, Sweden, 20.04.1989 1989 Soviet-Finnish Symposium in Rheumatology, "Subjective disease experience in Sjögren's syndrome." Volgograd, USSR, 05.06.-08.06.1989 1990 "Regulatory aspects of proteinases". Charing Cross Hospital, (Prof R. Maini), London, UK, 21.03.1990 1990 "Vitamin E status in patients with rheumatoid arthritis". Rheumatherapy on a New Course, Rottach-Egern, Germany, 10.11.-11.11.1190 11

1990 "Molecular biology of neuropeptides". Eastman Dental School, London, UK, 16.11.1990 1990 "Substance P". Grand Rounds, Cornell University, New York, NY, USA, 21.11.1990 1990 "Neuropeptides and innervation of bone". Seminar, Hospital for Joint Diseases, Orthopaedic Institute, New York, NY, USA, 28.11.1990 1990 "Serum zinc, copper and selenium in rheumatoid arthritis: relation to nutrition, disease activity and medication". First Düsseldorf Symposium "Malabsorption Syndromes and Organic Disorders Subject to Deficiencies on Vitamins and Trace Elements", Düsseldorf, Germany, 01.12.1190 1991 "The role of neuropeptides in Sjögren's syndrome". Seminar, Long Island Jewish Medical Center, Long Island, NY, USA, 14.02.1991 1991 "Vitamin E status of patients with rheumatoid arthritis: possible influences on enzyme activities". Antirheumatic therapy on a new course. An international workshop, Berlin, Germany, 23.03.1991 1991 "Adhesion molecules and neuropeptides in Sjögren's syndrome", Department of Pathology (Professor D.L. Gardner), University of Edinburgh, Scotland, 26.03.1991 1991 Co-chairman (together with Prof G. Ronca) of "Bone and cartilage pathology" session at the 4th Interscience World Conference on Inflammation. Antirheumatics, Analgesics, Immunomodulators. Geneva, Switzerland, 15.04.-18.04.1991 1991 "Molecular biology of neuropeptides", Department of Rheumatology, (Professor M.I.V. Jayson), University of Manchester, U.K., 25.04.1991 1991 Co-chairman (together with M. Schiødt) of the session "Histologic and Immunopathologic Studies in Sjögren's syndrome" at the Third International Symposium on Sjögren's syndrome, Ioannina, Greece, 20.06.-23.06.1991 1991 Chairman of the session "Neuromediators". XIIth European Congress of Rheumatology, Budapest, Hungary, 30.06.-06.07.1991 1991 Invited lecture "Neuropeptides in neuroimmunology", Department of Neurology, (Professor H Donnenfeld), St Vincents Hospital, New York, NY, USA, 15.07.1991 1992 EEC Comac Epidemiology Committee, Multicenter Study for the definition of diagnostic criteria for Sjögren's syndrome "Up-date". Pisa, Italy, 17.01.-19.01.1992 1992 Uppsala university "Molecular mechanisms in pain". Uppsala, Sweden, 05.02.1992 1992 Invited lecture "Pain in rheumatic disease". Revmasymposiet. Oslo, Norway. 24.04.-26.04.1992 1992 Chairman of the plenary lecture session and symposium "Interactions between the nerve system and immune system in rheumatic diseases". "Introduction." 24th Scandinavian Congress of Rheumatology, Malmö, Sweden, 31.05.-03.06.1992 1992 Plenary lecture in symposium "Interactions between the nerve system and immune system in rheumatic diseases". "Molecular biology of neuropeptides." 24th Scandinavian Congress of Rheumatology, Malmö, Sweden, 31.05.-03.06.1992 1992 Invited plenary lecture "Joint infection in chronic arthritis. A rheumatologist's view". 24th Scandinavian Congress of Rheumatology, Malmö, Sweden, 31.05.-03.06.1992 12

1992 Invited plenary lecture "Inflammation and autoimmune diseases". XXIV Conference, Scandinavian Association of Oral and Maxillofacial Surgeons, Mariehamn, Aland Islands, Finland, 12.08.- 16.08.1992 1992 "Neuropeptide nerves, pain and inflammation", The Autumn Meeting of the Estonian Society for Rheumatology, Tartu, Estonia, 23.10.1992 1992 Member of the International Scientific Advisory Board and invited chairman of a workshop "Experimental Studies", "Sixth International Seminar on the Treatment of Rheumatic Diseases". Tel Aviv, Israel. 13.12.-19.12.1992 1993 Invited lecturer, Neuromedical Department (Prof Olaf Paulson), Copenhagen, Denmark. "Peripheral, spinal and supraspinal pain mechanisms: relation to treatment". 05.02.1993 1993 Invited lecturer, The Danish Society of Rheumatology, Copenhagen, Denmark. "Neurogenic influence on the rheumatic inflammation". 26.02.1993 1993 "Inflammatory pain", Visiting Speaker Seminar, Faculty of Pharmacy and Pharmaceutical Sciences (Professor F. Jamali), University of Alberta, Edmonton, Alberta, Canada. 17.06.1993 1993 "Arthritis pain: special reference to the use of NSAID, corticosteroid, gold and physiotherapy", Resident Rounds, Rheumatology/Clinical Immunology (Professor Paul Davis and Professor Anthony S. Russell), University of Alberta, Edmonton, Alberta, Canada, 23.06.1993 1993 Chairman (together with Dr T. Sumida and Prof Y. Ichikawa) for Plenary Poster session "Immunologic Studies" at the IVth International Seminar on Sjögren's Syndrome. Tokyo, Japan, 11.08.-13.08.1993 1993 Invited lecture "Kobe Immunology Seminar" on "Sjögren's syndrome", Kakogawa National Hospital (Dr Shunichi Shiozawa), Kobe, Japan, 16.08.1993 1994 Nordisk Forskarakademi (NorFA) Network Meeting, Institute for Surgical Research: "Collagen and collagenases", Oslo, Norway, 07.02.1994 1994 "Molecular mechanisms in pain and inflammation". College of Dentistry, Gainesville, Florida, 28.03.1994 1994 "Extracellular matrix degradation". College of Dentistry, Gainesville, Florida, 29.03.1994 1994 "Chronic seronegative spondylarthropathies". Yamagata University Central Hospital, Yamagata, Japan, 11.11.1994 1994 "Molecular mechanisms of pain". Japanese Society of Rheumatism, Hokkaido-Tohoku District, Yamagata, Japan, 12.11.1994 1994 "Inflammation och smärta" Seminarium, Avdelning för oral patologi, Malmö Allmänna Sjukhuset, Malmö, Sweden, 21.12.1994 1995 "How rheumatic inflammation causes pain and how anti-inflammatory drugs relieve it." Pain in Rheumatic Diseases - physiology, diagnosis and treatment, Nycomed Pharma and Norwegian Society of Rheumatology, Holmenkollen, Norway, 31.03.1995 1995 "Pain mechanisms in fibromyalgia. Which drugs can interfere?" Pain in Rheumatic Diseases 13

-physiology, diagnosis and treatment, Nycomed Pharma and Norwegian Society of Rheumatology, Holmenkollen, Norway, 31.03.1995 1996 "NANC (=non-adrenergic, non-cholinergic) system in Sjögren's syndrome". Institute for Surgical Research, Oslo, Norway. 08.01.1996 1996 "Drug-mediated regulation of collagenases". Rikshospitalet, Oslo, Norway. 08.01.1996 1996 "Bone regulating cytokines in the loosening of totally replaced hips". Martina Hansens Hospital, Oslo, Norway. 09.01.1996 1996 "Non-adrenergic, non-cholinergic system in Sjögren's syndrome". Rigshospitalet, Department of Medicine TA, Copenhagen, Denmark. 26.01.1996 1996 Presentation about: “Felles Nordisk Pasientregister” theme. The Nordic Rheumatism Council Meeting, Hotel Admiral, Copenhagen, Denmark. 22.03.1996 1996 “Ankylosing spondylitis: sib pairs and extended families in Finland”. 2nd Meeting of the European Consortium for the Genetics of Annkylosing Spondylitis and Spondylarthropathies (ECASS). Meridien Hotel, Paris, France. 04.05.1996 1996 “Pathogenesis of Sjögren’s syndrome”. An invited plenary lecture, 26th Scandinavian Congress of Rheumatology, Reykjavík, Iceland. 02.06.1996 1996 “The eye in the rheumatic diseases”. An invited lecture, Clinica Medica IV, University of Firenze, Italy. 06.08.1996 1996 “The role of the synovial-like interface membrane in the loosening of THR”. Fortbildungsveranstaltung des Zentrums für Orthopädische Wissenschaften (ZOW). Münich, Germany. 21.09.1996 1997 “Sjögrens syndrom. Aktuella synpunkter på uppkomstmekanismer och terapi”. Rheumatology Unit, Karolinska Institutet/Hospital, Stockholm, Sweden, 17.01.1997 1997 “Sjögren’s syndrome: diagnosis, clinical manifestations and treatment”. Tallinn Central Hospital, Tallinn, Estonia. 25.08.1997 1997 “Peripheral nervous system in arthritis”. Pain, Rheumatic Diseases and Quality of Life. Firenze, Italy, 30.10.-01.11.1997 1997 Chairman: Free Communications. Pain, Rheumatic Diseases and Quality of Life. Firenze, Italy, 30.10.-01.11.1997 1997 “Effects of tetracyclines in Sjögren’s syndrome”. Non-antibiotic properties of tetracyclines. Organized by Long Island Jewish Medical Center and Albert Einstein College of Medicine. Garden City, New York, 14.11.1997 Invitations currently pending: Japan: Ohutsu, Kobe and Yamagata; USA: Tampa (FL)

CO-OPERATORS IN METROPOLITAN HELSINKI AREA:

Helsinki University Central Hospital/ HUCS: Department of Surgery, Töölö Hospital (Professor Seppo 14

Santavirta) Food and Drug Administration/ FDA: Medical Devices Section/ Joint implants (Director, Dr Juha Nevalainen) Faculty of Veterinary Medicine: Department of Pathology (Acting Professor Antti Sukura) University of Helsinki/ HY: Institute of Dentistry. 1) Department of Oral and Maxillofacial Surgery (Professor Maria Malmström); 2) Department of Oral Pathology/ Hard Tissue Laboratory (Professor Jarkko Hietanen); 3) Department of Periodontal Diseases/ Collagenase group (Acting Professor Timo Sorsa). Institute of Biomedicine: Department of Anatomy (Professsor Ismo Virtanen); Department of Physics, Acceleration Laboratory (Professor Asko Anttila and Doc Reijo Lappalainen)

MOST IMPORTANT INTERNATIONAL COOPERATION (documented with several joint publications with all):

Dr Lars Nordsletten (Oslo, Norway); Dr Per Aspenberg (Lund, Sweden); Dr Rolf Manthorpe (Malmö, Sweden); Dr Peter Oxholm (Gentofte, Denmark); Dr Ruth Sepper (Tartu, Estonia); Prof Harald Tschesche (Bielefeld, Germany); Dr Roeland Hanemaaijer (Leiden, The Netherlands); Prof Marco Matucci-Cernic (Florence, Italy); Prof Julia M. Polak (London, UK); Prof Carlos Lopéz-Otín (Oviedo, Spain); Prof Lorne M. Golub and Prof Robert A. Greenwald (New York, NY, USA); Dr Michiaki Takagi (Yamagata, Japan)

As to co-operation/ links to other Finnish researchers and Scientists abroad, I refer to my list of publications and to my CV (including the present and past visitors)