General Genetics

General Genetics Biology 290 Spring 2011

Instructor: Ann J. Murkowski Office: 2420A Suzanne Schlador 2429 Office Hours: Ann- Mon 3-3:50; Tue10-10:50; Wed Office Phone Number: 2-2:50; Suzanne-Mon/Wed 3-4 and by appt. 528-4511 (Ann); 528-4579 (Suzanne) Course Times: Tuesdays, 2-2:50, Thursdays, 2:00- Email: [email protected] 3:50 pm (AS 1521)and online [email protected]

Course Homepage http://northseattle.angellearning.com (Note that your 9-digit student ID Address: number is both your user name and password!) Required Text: Introduction to Genetic Analysis, 10th ed.; Griffiths et al.; W.H. Freeman Pub.

Course Description: A survey of modern genetics for science majors including: Mendelian inheritance, linkage and recombination, extensions of Mendel, sex determination, multifactorial traits, gene structure and function, mutations and chromosome abnormalities, population genetics, the human genome, genetic technologies, current applications (including cloning, genetic testing, genetically-modified plants and animals, gene therapy, and forensics), and related ethical issues.

Course Prerequisite: 10 credits of college-level biology (Bio 160 or 211 preferred; Eng 101 strongly eligibility recommended) Evaluation: Your grade is evaluated as Your grade is based on the following NSCC scale: follows:

Presentation 15% 4.0 - 3.5 A/A- 90-100% Homework (Chapter Reviews) 5% 3.4 - 2.9 B+/B 80-89.9% Pre-Class Assignments/Seminar Preps 10% 2.8 - 2.2 B-/C+ 70-79.9% In-Class Assignments 10% 2.1 - 1.5 C/C- 60-69.9% Weekly Online Quizzes (9) 15% 1.4 - 0.9 D+/D 50-59.9% Exams (2) 45% 0.8-0.0 D-/E below 50%

General Course Layout and Logistics: This is a hybrid course, meaning that you will be expected to participate in both our online and in-person activities throughout the quarter. Your nine-digit student ID number (with no spaces or dashes) serves as both your user name and password for our website. Please notify your instructors immediately if you have problems accessing any of the course content! In addition to the time spent thinking about genetics on your own time and in our online community, we will also meet twice each week. Each week will generally follow the same basic schedule shown below, as described on the course schedule.

Tuesday: Key Ideas Lecture and Discussion; Homework Due Thursday: In-class Assignment; Pre-class Assignment Due Sunday: Quiz on the previous week’s material due by midnight.

GENERAL POLICIES AND REMINDERS

Exams: We will have two exams this quarter. These exams will not be cumulative. Make up examinations are given only when prior arrangements have been made with the instructor. Make up exams may be in an alternate format. If prior arrangements are not made a 0% will be assigned for the missed exam.

Journal Club Presentation: Our on-going project this quarter will be to produce an informational PowerPoint presentation to share with our colleagues. This project is intended to help you refine and improve your ability to locate and synthesize information, develop your research and communication skills, and explore a topic of interest to you. Working scientists often give short talks as a quick way to present new work to others, and to stay current in their field. For this assignment, you’ll prepare a 7-10 minute PowerPoint presentation on a primary paper of your choice. Specific details about the project requirements and due dates will be provided on a separate handout and discussed in class.

Online Discussion: Our course website includes a threaded Discussion Room. At several points during the quarter we may ask you to post specific assignments to this space. In addition, you are free to use this space to connect with classmates, ask questions, etc.

Online Quizzes: There will be an online quiz each week to help you assess your understanding of the materials we’ve covered during the week. These quizzes are due by midnight on Sunday, and will cover the prior week’s content. You may use your text and notes for the quiz, but note that quizzes are timed (45 minutes each) and you will only have one chance at each quiz. Thus you should have read the readings and studied them thoughtfully before attempting the quiz!

Homework: We will provide a short set of reading questions for each chapter. These questions are due at the start of class each Tuesday and should help you focus on the critical ideas as you read each chapter.

Pre-Class Assignments: Most weeks will be focused around a single topic in genetics, and will culminate in a case study, activity, or paper that requires us to apply what we’ve been learning to a “real-life” scenario. To do this effectively, you will need to have read the case study or paper and completed the pre-class assignment (posted online) before coming to class each week. These pre-class assignments should be typed, and are due at the start of class on Thursday.

In-Class Assignments: We will generally follow this work we do on pre-class assignment with additional in-class work. When you arrive in class, you will generally be given more information about the case study or paper, and asked to prepare an analysis in groups. This group work will also be collected and graded each week.

Attendance and Commitment: Students should attend every class session. This is especially critical in a class that meets just twice per week. In addition, please think of your time online as additional class time! We expect and encourage you to take advantage of the online component to assess your learning and interact with both faculty and peers. We will do all we can to help students who must miss class due to illness or other emergencies, but must know as soon as possible. A student who stops attending class without an official withdrawal will be assigned a grade based on the work completed up to that point. This is an upper-level course that will require a great deal of individual effort by each of us. We have given you a detailed schedule of the quarter for a reason. With this schedule, you will be able to stay on top of the material, and should not be pressed for time. Attendance, attentiveness, and effort are essential for success in the class.

Electronic Devices: Out of respect for your instructor and fellow students, please turn off cell phones and pagers before class. No electronic devices may be used during exams.

Academic dishonesty will not be tolerated, and will result in a ZERO for the affected exam, quiz, or assignment. A second offense will result in a withdrawal from the class for the remainder of the quarter. A TENTATIVE SCHEDULE: BIOLOGY 290, SPRING 2011 Please note that this schedule may change. Check the webpage for updates, and listen in class for announced schedule changes!

Date In-class Activities: In-class Activities: Thursday Sunday Tuesday Week  Course Introduction  In-Class Assignment 1: Reviewing the  Quiz 1 due 1:  Genetic Approach To Biology Foundations of Genetics by 12 am! 4/4-4/8 (Ch. 1)  Pre-Class 1 Due  Seminar 1: PubMed Search Results  Presentation Guidelines & Brainstorm Week  Homework 1 Due  In-Class Assignment 2: Modeling a Journal Club  Quiz 2 2:  Lecture: Single Gene Presentation due, 12 am! 4/11- Inheritance (Ch 2)  Pre-Class 2 Due 4/15  Seminar 2: Fatal Cardiac Arrhythmia

Week  Homework 2 Due  Using Chi Square Analysis  Quiz 3 3:  Lecture: Independent  In-Class Assignment 3 due, 12 am! 4/18- Assortment (Ch 3)  Pre-Class 3 Due 4/22  Submit Journal Club Team and Statement of Interest

Week  Homework 3 Due  In-Class Assignment 4  Quiz 4 4:  Lecture: Mapping Eukaryotic  Pre-Class 4 Due due, 12 am! 4/25- Chromosomes (Ch 4)  Seminar 4/29

Week  Homework 4 Due  In-Class Assignment 5  Quiz 5 5:  Lecture: Gene Interactions  Pre-Class 5 Due due, 12 am! 5/2-5/6 (Ch 6)

Week  Lecture: DNA (Ch 7)  Exam 1  Quiz 6 6:  In-Class Assignment 6: DNA due, 12 am! 5/9- Structure and Function: 5/13 Exploring Telomeres

Week  Homework 5 Due (Ch 7 & 8)  In-Class Assignment 7: Applications of RNAi  Quiz 7 7:  Lecture: RNA (Ch 8)  Pre-Class 6 Due due, 12 am! 5/16- 5/20  Journal Club 1:______ Journal Club 2:______ Journal Club 3:______

Week  Homework 6 Due  The Ghost in Your Genes  Quiz 8 8:  Lecture: Regulating Gene  Pre-Class 7 Due due, 12 am! 5/23- Expression (Ch 12)  In-Class Assignment 8 5/27  Introduction to Genomes and Genomics  PPT Slides Draft Due  Journal Club 4:______ Journal Club 5:______ Journal Club 6:______

Week  Homework 7 Due  Guest Speaker: Microarrays  Quiz 9 9:  Lecture: Genomes and  Pre-Class 8 Due due, 12 am! 5/30- Genomics (Ch 14)  In-Class 9: Using BLAST to explore the Genome 6/3 (In-Class Assignment 8)  Journal Club 7:______ Journal Club 8:______ Journal Club 9:______ Homework 8 Due  Presentations  Quiz 10 due, 12 Week  Lecture: Mutation, Repair,  Pre-Class 9 Due am! 10: and Recombination (Ch 16);  Journal Club Chromosomal Abnormalities 10:______6/6- (Ch 17- Select readings)  Journal Club 6/10 11:______ Journal Club 12:______ Journal Club 13:______

 In-Class 10: Molecular  Exam 2, 3:15-5:15 Causes of Cancer Week  Course Evaluations 11: 6/13- 6/17