Table E-1 (Supplement) Correlations Between Disease Characteristics and Sleep Parameters

Corben MS ID#: Neurology/2012/499475

Table e-1: Correlations between disease characteristics and sleep parameters

Disease Sleep REM Total Sleep NREM REM (Min) Total RDI ODI ODI (4%) characteristics onset latency Sleep Efficiency (Min) (3%)

Latency Age at -0.24 -0.62** -0.57* -0.24 -0.42 -0.21 0.37 0.32 0.33 assessment Age at disease -0.06 -0.33 -0.31 0.07 -0.23 -0.03 -0.05 -0.07 -0.00 onset Disease duration -0.41 -0.49* -0.36 -0.12 -0.26 -0.15 0.44* 0.39 0.36 BMI -0.09 -0.38 -0.06 0.03 -0.17 0.38 0.41 0.51 0.47 GAA1 0.09 0.07 0.36 -0.06 0.42 -0.17 0.34 0.39 0.32 GAA2 0.46 -0.41 -0.28 -0.27 -0.25 -0.08 -0.28 -0.28 -0.29 FARS -0.31 -0.25 -0.11 -0.14 0.10 -0.31 0.42 0.42 0.41

(p=0.06) MBI 0.41 0.11 0.03 0.02 -0.15 0.29 -0.35 -0.25 -0.27 FIM 0.35 0.06 -0.01 0.05 -0.16 0.27 -0.30 -0.20 -0.23 Legend: BMI: Body Mass Index; GAA1: GAA repeat size of the smaller FXN allele; GAA2: GAA repeat size of the larger FXN allele; FARS: Friedreich Ataxia Rating Scale; MBI: Modified Barthel Index; FIM: Functional Independence Measure; REM: Rapid

Eye Movement; NREM: Non Rapid Eye Movement; Total RDI: Total Respiratory Disturbance Index; ODI: Oxygen Desaturation

**p value<0.01; *p value<0.05 Corben MS ID#: Neurology/2012/499475 Corben MS ID#: Neurology/2012/499475

Table e-2: ESS, Total RDI and oxygen desaturation index according to OSA groupings.

OSA Groups Participant ESS Total RDI ODI 3% ODI 4% No OSA 1 5 0 0 0 2 3 1.5 0.9 0.3 RDI < 5 /hr 3 5 1.6 0.2 0 4 18 3.1 1.9 0.6

Mild OSA 5 11 5.1 4 1.9 6 2 6.8 1.3 1 RDI 5-20/hr 7 * 7 * * 8 6 7.1 * * 9 3 7.4 6.6 1.9 10 10 9 * *

11 1 9.4 23.7 11.4 12 8 13.1 * * 13 10 14 * *

Moderate 14 * 21.6 * * 15 6 24.6 16.6 13.1 OSA 16 4 25.6 * *

RDI 20-30/hr Severe OSA 17 12 48.7 44.6 42.8 18 * 32.3 31 26.6 RDI >30 /hr 19 19 42.6 47.2 39.1 20 4 51.6 17.6 11.6 21 * 59.4 50.3 45.2

Legend: BMI: Body Mass Index; Total RDI: Total Respiratory Disturbance Index;

ODI: Oxygen Desaturation Index

* Data not available