Tumor Spectra in Cohorts of Dmp1-/-, Dmp1+/-, and Dmp1+/+ Mice

Supplementary Data A: Tumor spectra in cohorts of Dmp1-/-, Dmp1+/-, and Dmp1+/+ mice

Tumor Type Number of tumors

Dmp1-/- mice (spontaneous tumors in 31 of 33 animals by 103 weeks observation)

Pulmonary tumors: adenoma 9 adenocarcinoma 5 Vascular tumors: hemangioma 5 hemangiosarcoma 3 Hepatocellular tumors 6 Lymphoma (B-cell) 5 Leiomyosarcoma 2 Intestinal adenocarcinoma 1 Mandibular carcinosarcoma 1 Peripheral nerve sheath tumor (malignant) 1 Histiocytic sarcoma 1 Epidermal tumor of skin 1

Dmp1-/- mice (tumors in 50 of 50 DMBA-treated animals by 67 weeks observation)

Pulmonary tumors: adenoma 23 adenocarcinoma 13 Epidermal tumors of skin 18 Ovarian tumors 10 Lymphoma: T-cell 6 B-cell 1 Melanoma 6 Hemangioma 4 Hepatocellular tumor 2 Intestinal adenocarcinoma 1

Dmp1-/- mice (tumors in 25 of 25 irradiated animals by 88 weeks observation)

Lymphoma: T-cell 6 B-cell 1 unknown type 1 Ovarian tumors 7 Pulmonary tumors: adenoma 2 adenocarcinoma 1 Hepatocellular tumors 3 Pituitary tumors 3 Endometrial carcinoma 1 Spindle cell sarcoma 1 Histiocytic sarcoma 1 Dmp1+/- mice (spontaneous tumors in 37 of 60 mice by 110 weeks observation)

Lymphoma: B-cell 13 T-cell 1 mixed T- and B-cell 2 Pulmonary tumors: adenoma 4 adenocarcinoma 7 Histiocytic sarcoma 6 Hemagiosarcoma 3 Hepatocellular tumors 2 Mammary carcinoma 2 Ovarian tumor 1 Uterine deciduoma 1 Sebaceous gland adenoma 1

Dmp1+/- mice (tumors in 23 of 25 DMBA-treated mice by 78 weeks observation)

Pulmonary tumors: adenoma 12 adenocarcinoma 5 Epidermal tumors of skin 9 Lymphoma: T-cell 4 B-cell 1 Ovarian tumors 5 Hepatocellular tumors 4 Hemangioma 2 Melanoma 1 Histiocytic sarcoma 1

Dmp1+/- mice (tumors in 16 of 25 irradiated mice by 79 weeks observation)

Hepatocellular tumors 8 Lymphoma: B-cell 4 T-cell 2 Histiocytic sarcoma 2 Pulmonary adenocarcinoma 1 Ovarian tumor 1 Osteosarcoma 1 Hemangioma 1 Harderian gland adenoma 1

Dmp1+/+ mice (spontaneous tumors in 9 of 45 mice by 110 weeks observation)

Lymphoma: B-cell 5 Histiocytic sarcoma 3 Pulmonary adenoma 1 Dmp1+/+ mice (tumors in 6 of 25 DMBA-treated mice by 78 weeks observation)

Epidermal tumors of skin 5 Pulmonary adenoma 3

Dmp1+/+ mice (tumors in 5 of 25 irradiated mice by 79 weeks observation)

Lymphoma: T-cell 2 B-cell 1 Pulmonary adenoma 1 Hepatocellular tumor 1 Nerve sheath tumor 1 Hemangioma 1