Bio-Data of Dr. Muthyala Murali Krishna Kumar

Bio-data of Dr. Muthyala Murali Krishna Kumar

Educational background:

Qualification University Marks/percentage Year Ph.D.In Pharmaceutical Andhra University, Degree awarded in Chemistry Visakhapatnam, 2006 M.Pharm Andhra University, 72% 2001 (Pharmaceutical Visakhapatnam, chemistry)

Teaching/research experience:

Assistant Professor, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – April 2008 to till date

Lecturer, Chemistry group,BITS-Pilani, Rajasthan – July 2007 to April 2008

Senior Research Fellow (SRF) in DOD funded National Project “Drugs from The Indian Ocean – AU2” in the College Of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh. - August 2001 to March 2006

Research Projects:

1. A multi Disciplinary National Project funded by CSIR-NMITLI, New Delhi, India titled “ Biofuels from marine micro algae” from 2011-2013 (first phase completed); applications were submitted for the second phase. Sanctioned Grant – INR 2.37 crores

Role: Co-investigator; Extraction and analysis of biofules with chromatography and spectral methods.

2. DST-SERB Project titled “Synthesis and screening of novel lamellarin analogues as potential agents against Mycobacterium tuberculosis” Sanctioned grant: INR 24.5 lakhs

Role: Principal Investigator

Lectures deliveredas a Resource Person :

1. ‘ NMR-A Powerful Tool for Structure Elucidation of Natural Products’ at Andhra University, Visakhapatnam during AU Research Forum Meeting. (21 July 2008) 2. An expert talk on Marine Natural Products, delivered during AICTE sponsored Staff Development Program on Recent Trends in Drug Design & Delivery Systems at Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa. (5-18 July, 2009) 3. ‘Shape Based Virtual Screening : Applications in Drug Repurposing for tuberculosis’ at Andhra University, Visakhapatnam during AU Research Forum Meeting. (9thFeb2014) 4. “ Marine Sponge Derived Microbes: A potential Source for Novel Bioactive Secondary Metabolites”, delivered at Kakatiya University, Warangal during QIP program. ’Advances in Medicinal Chemistry’ (15th November 2014)

Workshops organized : 1. Workshop on principles and practice of spectroscopy – A workshop organized during February every year for the students of Andhra University and affiliated colleges. 2. Summer research camp titled “Hands-on training in Computer Aided Drug Design”– 5th may to 4th June 2011 at College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 3. Conducted one session on “‘Natural Product Databases and their application in drug discovery” National workshop on “A Holistic Approach to Identify Bioactive Molecules From Natural Origin” at College of Pharmaceutical Sciences, Andhra Unvierity, Visakhapatnam from 21st November to 3rd December 2012. 4. Conducted a workshop on “Spectroscopy in the structure elucidation of organic molecules” at Sai Siddhardhapharmacy College, Nuzvid, Andhra Pradesh. 5. Conducted one session on “Latest Trends in Pharmaceutical Chemistry Teaching and Research-CADD”in AICTE sponsored Staff Development Program on "Current activities and future perspectives in Pharmaceutical Chemistry Research and Development" at Hindu College of Pharmacy, Guntur from20thApril to 4thMay 2013. 6. Conducted an UGC funded workshop on "Principles and Practice of Rational Drug Design in Teaching and Research" on 28-29th December 2013 at College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 7. Conducted two sessions in a workshop on “Molecular Modelling and Drug Design” on 27th to 30th January 2015 organized by The Bioinformatics Infrastructure Facility, Andhra University. 8. Indian Co-coordinator for the Preconference workshop on “Spectroscopic Methods in Phytomedicines” conducted 20th March 2015 as a part of 2ndInternational Conference of Society of Pharmacognosy.

Workshops/Training courses attended:

1. Undergone ITW (Intensive Teachers Training Workshop) for faculty at BITS, Pilani – India. September-November 2007 2. Participated in the InterdisciplinaryUGC-Sponsored refresher course at UGC-academic staff college, Andhra University, Visakhapatnam – November 9-29,2009. 3. Workshop on Advances in Bioinformatics in Teaching Biology and Research at Department of Marine Living Resources, Andhra University, Visakhapatnam - February 12-14, 2010 4. Participated in workshop on Molecular modeling and drug design at university of Hyderabad, Hyderabad, August 2-7, 2010. 5. Participated in UGC-Sponsored Faculty Orientation Program at UGC-academic staff college, Andhra University, Visakhapatnam – January 19th to 15th February. 6. Participated in SAKSHAM training programon “ITC based teaching methodologies” conducted by MHRD, India and Microsoft from 9th to 20th April 2013. 7. Participated in “Workshop onDevelopment of Industry and Hospital Oriented syllabus for Pharmacy students” at College of Pharmaceutical Sciences, Andhra University, Visakhapatnam on 6th and 7thMarch 2013. 8. Participated in 19th short term training course on “Molecular techniques as applied to Infectious diseases” held at Mahatma Gandhi Institute of Medical Sciences, Sewagram from 23rd February 2014 to 1st March 2014. 9. Participated in 66th Indian Pharmaceutical Congress held at Hyderabad from 23rd to 25th January 2015 as a poster evaluator for medicinal chemistry section.

Oral/poster presentations at conferences: 1. Phenothiazine – new scaffold for selective antitubercular drug design - National symposium on Innovation in TB Diagnostics, Drug targets and Biomarkers &C.M.E. on Innovation in Molecular and Immunodiagnostics for PTB&EPTB in India on 27-28th Jan. 2014 at Mahatma Gandhi Instiute of Medical Sciences, Sevagram (Wardha), Maharashtra, India. (K. PurnaNagasree, K.Madhavi, P.RaghuveerVerma, Y.Pradeep Kumar, M. MuraliKrishna Kumar )

2. Repurposing drugs: vROCS based screening and identification of selective antitubercular agents from drug database - National symposium on Innovation in TB Diagnostics, Drug targets and Biomarkers &C.M.E. on Innovation in Molecular and Immunodiagnostics for PTB&EPTB in India on 27-28th Jan. 2014 at Mahatma Gandhi Instiute of Medical Sciences, Sevagram (Wardha), Maharashtra, India. (M. Muralikrishna Kumar, Y. Pradeep Kumar, P. RaghuveerVerma and K. PurnaNagasree)

3. Oral Presentation on ACTIVATING MACROPHAGES- A NOVEL WAY TO WARD OFF MYCOBACTERIAL MENACEpresented at Indian Immunology Society CME& National Seminar on Immune Interface of Host-Pathogen Interactions on 7-8th December, 2013 at Andhra University, Visakhapatnam, India. (K. PurnaNagasree, K. Kundan,N. Vamsikrishnaand M. Muralikrishna Kumar)

4. New leads from drug database – A case study, presented at Indian Pharmaceutical Congress (IPC) held at SRM University, Chennai, December 05-07, 2012. (Murali krishna Kumar M, Aruna B, Anusha K and PurnaNagasree K 5. Ligand protein inverse fit docking of briaranediterpenoids presented at Indian Pharmaceutical Congress (IPC) held at SRM University, Chennai, December 05-07, 2012. Murali krishna Kumar M, Tahzeeb U.N, Shalini N and PurnaNagasree K

6. Enzyme targets for apresented at Indian Pharmaceutical Congress (IPC) held at SRM University, Chennai, December 05-07, 2012. Murali krishna Kumar M, David Raju S, Girija K and PurnaNagasree K

7. Isolation of actinomycetes species from marine sponge Hyatella presented at National seminar on Chemistry of bio-active natural products held at MVR Degree & PG College, Visakhapatnam, India. 16-17th March, 2011. G.V. Hemanth, P. Anitha, M. Muralikrishna Kumar and G. Girija Sankar

8. Isolation of pencillium species from marine sponge Axinella presented at National seminar on Chemistry of bio-active natural products held at MVR Degree & PG College, Visakhapatnam, India. 16-17th March, 2011. G.P.V. Sangeeta, A. Srinivasarao, M. Muralikrishna Kumar and G. Girija Sankar

9. Bioactive secondary metabolites from sponge associated marine microbes presented at National seminar on Chemistry of bio-active natural products held at MVR Degree & PG College, Visakhapatnam, India. 16-17th March, 2011. M. Muralikrishna Kumar, G. Girija Sankar and swathisri

10. Synthesis, Biological and Computational Studies on Thiazolidine Analogues as PromisingAntitubercular Compounds presented at YRC-YICC held at ICT, Mumbai, January 13-14, 2011. PurnaNagasree K., Muralikrishna Kumar M., Rajendra Prasad Y., Vasudeva Rao A and Shalini K V. (Won Young Researcher’s award under pharmacy category)

11. Computational Methods for Novel & Selective Antitubercular Drug Target Search and its Applications in Drug Discovery presented at 2nd international conference on current status and future perspective in pharmaceutical sciences at PES college of pharmacy, Bangalore (Vasudeva Rao A., Murali Krishna Kumar M., PurnaNagasree K. and Rajendra Prasad Y.)

12. ‘ Virtual screening- A viable source for novel ligands to fight against TB’ presented in workshop on Molecular modeling and drug design at university of Hyderabad, Hyderabad, August 2-7, 2010. (Muralikrishna Kumar M., PurnaNagasree K., Vasudeva Rao A.)

13. Bioactive secondary metabolites from the symbiotic microbes isolated from toxic spray of marine invertebrate Zoanthus sp. Presented in 4th international symposium on current trends in drug discovery research at CDRI, Lucknow, 17-21 February 2010. (O. Veer kumar reddy, M. Muralikrishna kumar, G. Girija sankar and D. Venkata rao) 14. ‘ Novel persistent tb targets: IsocitrateLyase – Glyoxylate shunt enzyme’ presented in the Bioflare ’09, at ANITS – Vizag, December 11-12, 2009. (Vaidehi B, PurnaNagasree K, Rajendra Prasad Y., MuraliKrishna Kumar M.) Won Consolation Prize

15. Synthesis of N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as novel th D2 Antagonists presented in the 12 International Conference on the Interface of Chemistry-Biology in Biomedical Research at BITS, Pilani, India – February 22-24, 2008. (Murali Krishna Kumar M., Chandra Sekhar K.V.G., Rao V.S.)

16. New sphingolipids from marine sponge Aurora globostalletta , presented in the International symposium on New frontiers in Marine Natural Product Research (NFMNPR) at National Institute of Oceanography, Goa, India – February 23-24, 2007 (Murali Krishna Kumar M., Venkata Rao D.)

Research Publications:

National: 6 International: 16 Communicated: 2

1. N.Krishna, P.Muralidhar, M. Murali Krishna Kumar, D. Venkata Raoand Ch. Bheemasankara Rao, Juncenolide B, A New briaranediterpene from the gorgonian Junceellajuncea of the Indian Ocean., Asian J. Chem., 15, 344-348 (2003). 2. P.Muralidhar,N.Krishna, M. Muralikrishna Kumar, Ch.Bheemasankara Rao,and D.Venkata Rao New sphingolipids from a marine sponge Iotrochotabaculifera, Chem.Pharm.Bull. 51 (10), 1193 (2003). 3. N.Krishna, P.Muralidhar, M. Muralikrishna Kumar, D.Venkata Rao and Ch.Bheemasankara Rao, A new sphingolipid from the gorgonian Junceellajuncea of the Indian Ocean, Nat. Prod. Res., 18, 551 (2004). 4. N.Krishna, P.Muralidhar, M. Muralikrishna Kumar, D.Venkata Rao and Ch.BheemasankaraRao,Newsphingosine derivatives from the Indian Ocean Gorgonian Pseudopterogorgiaaustraliensis, J. Nat. Prod., 67, 1423 (2004) 5. P.Muralidhar, M. Muralikrishnakumar, N.Krishna, D.Venkata Rao and Ch.Bheemasankara Rao, New sphingolipids and a sterol from a Lobophytumspecies of the Indian Ocean, Chem.Pharm.Bull. 53 (2), 168 (2005) 6. P.Muralidhar,N.Krishna, M. Muralikrishna Kumar and D.Venkata Rao, Chemical constituents of a marine sponge Echinodictyumgorgonoides,Proceedings of Ap. Acad. of Sci., 9, 125 (2005) 7. M. Muralikrishna Kumar, P. Muralidhar,N.Krishna, and D.Venkata Rao, A new scalaranesesterterpene derivative from the marine sponge Hyatellacribriformisof Indian Ocean, Proceedings of Ap. Acad. of Sci., 9, 131 (2005) 8. V.V.S.S.Appala Raju, M.Ramesh, A.LakshmiNarasu and M.Murali Krishna Kumar, Antimicrobial activity of the plant Schyzyziumalternifolium, Asian J. Chem., 19, 4923-24 (2007). 9. M. Muralikrishna Kumar, N. Krishna, P.Muralidhar and D.Venkata Rao, A New scalaranesesterterpenes from the marine sponge Hyatellacribriformisof the Indian Ocean, Ind. J Chem, 47B, 325-329 (2008) 10. K.V.G Chandra Sekhar, V.S Rao, D Ravi Kumar Vyas, M Murali Krishna Kumar, Synthesis of N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as novel atypical antipsychotics, Bioorg.Med.Chem.Lett, 23(1), 6054-6057 (2008) 11. Chandra Sekhar, K.V.G., Rao V.S., Murali Krishna Kumar M., Synthesis and preliminary screening of novel N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides as potential atypical antipsychotic agents. J. Enzyme Inhib. Med. Chem. 2009, Vol. 24, No. 3 : Pages 871-875 12. Vasudeva Rao Avupati, PurnaNagasreeKurre., SanthoshiRupaBagadi., Murali Krishna Kumar Muthyala, Rajendra Prasad Yejella. Denovo based ligand genereation and docking studies of PPAR δ agonists. Correlations between predicted bioloticalactivity vs. Biopharmaceutical descriptors. Chem-Bio Informatics Journal, Vol. 10, pp. 61-76 (2010) 13. Vasudeva Rao Avupati., Murali Krishna Kumar Muthyala., Rajendra Prasad Yejella. Computer assisted molecular docking and 3D QSAR studies on 1,3,5-trisubstituted aryls as PPAR agonists, Int.J.Pharm.Tech, 2010, 2(4) 977 14. Gaddam Sandeep, KurrePurnaNagasree, MuppaneniHanisha and Muthyala Murali Krishna Kumar, AUDocker LE: A GUI for virtual screening with AUTODOCK Vina. BMC Research Notes 2011, 4:445. 15. KondapalliVenkataGowri Chandra Sekhar, VajjaSamabasiva Rao, Winnie Deuther- Conrad, Aravalli Satish Reddy, Peter Brust, and Mutyala Murali Krishna Kumar, Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5- disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3- carbonitriles as atypical antipsychotic agents, Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, 561–8. 16. VenkataRatna Ravi Kumar Dasari, Murali Krishna Kumar Muthyala, Murali YugandharNikku, Sri Rami Reddy Donthireddy, Novel Pyridinium compound from marine actinomycete, Amycolatopsis alba var.nov. DVR D4 showing antimicrobial and cytotoxic activities in vitro, Microbiological Research 167 (2012) 346– 351 17. KondapalliVenkataGowri Chandra Sekhar, VajjaSambasiva Rao, Winnie Deuther-Conrad, Divya Sridhar, HunsurNagendraNagesh, VellasSreedhar Kumar, Peter Brust and Muthyala Murali Krishna Kumar, Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1- yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents; Med Chem Res (2013) 22:1660–1673 18. M.Srinu, M. Murali Krishna Kumar, G. Girija Shankar, Actinomycin “D” from marine sediment associated Streptomyces capillispiralis mtcc10471, Asian J PRHC (2013) 5:16- 23. 19. SmithaDesaraju, Murali Krishna Kumar Muthyala, RamanaHechhu and Venkata Rao Desaraju, Rubrolide R: A new furanone metabolite from the ascidian Synoicum of the Indian Ocean,Natural Products Research, (2014)28: 12-17. 20. Muthyala Murali Krishna Kumar, JarpulaDevilalNaik, KancherlaSatyavathi, HechhuRamana, PemmadiRaghuveer Varma, KurrePurnaNagasree, DesarajuSmitha&DesarajuVenkata Rao, Denigrins A-C: New antitubercular 3,4- diarylpyrrole alkaloids from Dendrilla nigra, Natural Products Research (2014) 28: 888- 894.

21. KurrePurnaNagasree, Muthyala Murali Krishna Kumar, Yejella Rajendra Prasad, DharmarajanSriram and PerumalYogeeswari, 3D QSAR Analysis of 2-(Substituted Aryl)- Thiazolidine-4-Carboxamides as Potent Antitubercular Agents, Current Computer-Aided Drug Design, 2014, 10 (3), 274-281.

22. Muthyala Murali Krishna Kumar, KandimallaMadhavi, PemmadiRaghuveer Varma, JammulamudiRisyNamrata and KurrePurnaNagasree, Shape Based Virtual Screening and Discovery of Potential Antitubercular activity in ‘Non-antibiotics’, International Journal of Drug Design and Discovery (accepted)

23. Saroj Kumar Sahoo, KurrePurnaNagasree, JamullamudiRisyNamratha, Pemmadi, Raghuveer Varma, Muthyala Murali Krishna Kumar, Synthesis and screening of new maleimide derivatives as potential antitubercular agents(Journal of Applied Pharmaceutical Sciences; accepted) 24. Raghuveer Varma Pemmadi, MadhaviKandimalla, PurnaNagasreeKurre, RisyNamrataJammulamudi, Annapurna Akula, Murali Krishna Kumar Muthyala, Design, microwave assisted synthesis and SAR studies of novel hybrid phenothiazine analogs as potential antitubercular agents. (Arabian Journal of Chemistry; under review)

Books and other publications: Contributed a book Chapter titled “Kinase Inhibitors from Microorganisms” in the Chapter 8 of the 44th volume of “Studies in Natural Products Research”(Elsevier Publications) Edited by Prof Atta-ur-Rehman. Softwares developed: AUDocker LE and AUDocker – Open source software GUIs to work with AUTODOCK Vina, useful forvirtual screening and ligand optimization. (more than 2000 downloads from over 75 countries)Web link: http://sourceforge.net/projects/audocker/?source=directory Technical expertise: Expertise in handling

1. LCMS-Agilant 6810 Triple Quadrupole 2. Microwave parallel synthesizer – BIOTAGE; Library synthesizer – RADLEY 1. HPLC – Waters; FLASH Chromatography – SEPACORE-BUCHI; MPLC - BUCHI 1. Rotavapors – BUCHI & HEIDOLF 1. Freeze dryer - CHRIST BETA 1. FTIR Spectrometer- Shimadzu, Bruker Alpha-T Softwares: General: Microsoft office applications Scientific: ChemBioDraw, AUTODOCK Vina, MODELLER, Molegro Virtual Docker, OpenEye Scientific software, online Bioinformatics Tools Courses Taught B.Pharmacy: organic chemistry, medicinal chemistry, applied biochemistry, natural products M.Pharmacy: advanced medicinal chemistry, chemistry of natural products, instrumental methods of analysis Pharm.D: medicinal biochemistry MSc: Physical chemistry, organic chemistry, instrumental methods of analysis Project work for all the above students

Membership/Executive positions in professional bodies

S.N Name of the association/ National/Internationa Status o Organization l 1. Andhra Pradesh Pharmacy Council’s National Active Registered pharmacist A1 030819 – 2000 2. Life member of Association of Pharmacy National Active Teachers in India (APTI) RA/LM- 126 – 2007 3. Life member of Indian Pharmacy Graduate’s National Active Association (IPGA) LM-3329

Personal details:

Office address Residential address Dr. Muthyala Murali Krishna Kumar Dr. Muthyala Murali Krishna Kumar M.Pharm., Ph.D. Flat No 106, Assistant Professor, Waltair Heights Apartment, Medicinal Chemistry Division, Opp AU Out Gate, College of Pharmaceutical Sciences, China Waltair, Andhra University, Visakhapatnam -530003 Vishakapatnam – 530 003 Phone No. +919441419246 INDIA

Date of birth: 29-8-1977

Marital status: Married