Associate Professor with Tenure, Department of Neurology

Curriculum Vitæ George Frederick Wittenberg, M.D., Ph.D. Associate Professor with Tenure, Department of Neurology University of Maryland School of Medicine

D a te 9 October 2016

C ont a ct Inform a tion

Baltimore VAMC, GRECC 10 N Greene St (BT/18/GR) Baltimore, MD 21201-1524 Ph: (410) 706-4456 Fax: (410) 605-7913 G Witt e nb@ GR E CC .UMaryland. e du

Foreign Languages: working knowledge of Dutch, German, Spanish, French, Hebrew

Edu c a tion

1980-1983 A.B. cum laude in Engineering and Applied Sciences (“Bioelectricity” Specialization) Harvard College, Cambridge, 1983 Laboratory course: Neural Systems and Behavior (1 month) Marine Biological Laboratories, Woods Hole, MA, 1984-1986 Medical student, School of Medicine, University of California, San Diego 1986-1991 Dept. of Biology, University of California, San Diego, Graduate student in laboratory of William B. Kristan, Jr., PhD., Dissertation: “Intersegmental coordination of shortening behavior in the leech.” Ph. D. granted 3/1991 1987 Marine Biological Laboratories, Woods Hole, MA, Laboratory course: Cellular Neurobiology in the Leech 1991-1992 School of Medicine, University of California, San Diego, Medical student 1993 M.D. granted, School of Medicine, University of California, San Diego P o st G r a du a te Edu c a tion a nd T r a ining George F. Wittenberg, MD, PhD p. 1 1993-1993 Visiting Post-doctoral Fellow (1 month), Dept. of Biology, UCSD, Laboratory of William B. Kristan, Jr. 1993-1993 Visiting Scientist (3 months), Scripps Research Institute, La Jolla, CA Laboratory of Donna L. Gruol, Ph.D. 1993-1994 Intern Physician, Dept. of Medical Education, Mercy HealthCare, San Diego, CA 1994-1997 Resident Physician, Dept. of Neurology, Washington University, St. Louis, MO 1997-1998 Neurorehabilitation Fellow, Dept. of Neurology, Washington University, St. Louis, MO 1998-2000 Senior Staff Fellow, Human Cortical Physiology Section, Medical Neurology Branch, NINDS, NIH, Bethesda, MD 1998-1999 Clinical Research Training Program, Duke University, Durham, NC (teleconference attendance at NIH, Bethesda, MD) 2012-2013 Senior Fellow, KU Leuven, Dept. of Kinesiology, Leuven, Belgium

C e r tifi c a tion s

1994 Diplomate, National Board of Medical Examiners, #352056 1998-2018 Board Certified in Neurology, American Board of Psychiatry and Neurology 2000 Certified Member, American Society of Neurorehabilitation

M e di c a l L i c e nsu r e s

1997 Missouri medical license, expired. 2000 North Carolina medical license, inactive 2000 Maryland medical license, active.

Em p lo ym e n t H i s to ry

Ac a d e mic A pp ointm e nts

2000-2006 Assistant Professor of Neurology, Wake Forest University 2006-2008 Assistant Professor of Neurology, UM SOM 2006-present Staff Physician, GRECC, Baltimore VAMC 2006-present Associate Faculty – University of Maryland School of Medicine Graduate School, Program in Neuroscience 2006-2008 Assistant Professor (secondary), Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine

George F. Wittenberg, MD, PhD p. 2 2008-present Associate Professor (secondary) – Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine 2008-present Associate Professor of Neurology, UM SOM 2012 Tenure awarded, UM SOM 2015-present Associate Professor (secondary) – Medicine/Gerontology & Geriatric Medicine, University of Maryland School of Medicine

Oth e r Em p loym e nt

1983-1984 Research Assistant in laboratory of Emil Unanue, Dept. Pathology, Harvard Medical School, Boston, MA

P r o f e ss ion a l S o c i e ty M e m b e rs hi p s

1986-present Society for Neuroscience 1995-present* American Academy of Neurology 1998-present American Society of Neurorehabilitation, Fellow 2000-2006 American Physiological Society 2000-present American Heart Association Stroke Council 2001-present* Organization for Human Brain Mapping 2004-present* Neural Control of Movement Society 2009-present* International Society of Motor Control 2009-present American Neurological Association, Fellow 2014-present Institute of Electrical and Electronics Engineers *with some gaps in membership Honors a nd Aw a rds

1994 Mercy Hospital “Outstanding Transitional Intern on the Pediatric Service” and “Certificate of Excellence” 1996 American Academy of Neurology Meeting Scholarship 1999 World Congress of Neurorehabilitation - Presidential Award for best presentation by a physician-in-training 2002-2005 Wake Forest University - Research Excellence Award

C linic a l Activiti e s

Clinical expertise: Inpatient and outpatient neurorehabilitation; Botulinum toxin injection for dystonia and spasticity; Baclofen intrathecal pump evaluation and management; Cerebrovascular disease; Movement disorders; General neurology.

George F. Wittenberg, MD, PhD p. 3 Scope of clinical practice: UMROI: cover CVA and Traumatic Brain Injury inpatient services (approx. 50 patients) every fifth weekend and additional holidays.

VAMHCS Baltimore, Neurology Consults and Outpatient attending one month a year, with approximately 20 new consults and 240 outpatients during that time.

UMMC, Brain Attack Team and Stroke Inpatient attending, one half- month each year. Approximately four admissions and two new consults each day.

Neurology Outpatient Center (Frenkil Bldg.): Brain Health and Spasticity outpatient practice twice a month (Initiated 2013.)

Total time spent in clinical duties: equivalent of 70 working days/year.

Innovative techniques that have changed or influenced practice: botulinum toxin injection of spastic muscles of upper or lower extremities, followed by functional electrical stimulation of paretic muscles of the same limb.

Modifications to clinical enterprise: helped design better process for screening patients for Brain Health and Spasticity Clinic, with more physician input to decisions regarding baclofen intrathecal therapy and better communication regarding intrathecal baclofen trials. Also started new practice in Frenkil Building in partnership with UMMC PT service.

Development of clinical program’s administrative service:

2005-2006 Interim Director of Rehabilitation Program of the Wake Forest University Dept. of Neurology. Directed physicians who comprised the Rehabilitation group within the Department of Neurology. Responsibilities included recruitment, practice issues, and coordination with School of Medicine and NC Baptist Hospital administration.

Administr a tive S e rvice

George F. Wittenberg, MD, PhD p. 4 Institution a l S e rvice 2003-2005 Western North Carolina chapter of Society for Neuroscience Secretary/Treasurer Helped organize a half-day symposium “Neuroengineering” and numerous visits by distinguished neuroscientists. 2002-2004 Residency Committee (Department of Neurology, Wake Forest) I interviewed candidates and participated in the ranking procedure. 2003-2006 Research Committee (Department of Neurology, Wake Forest) 2004-2006 MRI Research Committee – Wake Forest University acquired a research MRI scanner while I was there. I was involved in defining the procedures for access to this resource and reviewed protocols for pilot funding and administrative approval. 2006-present Staff Physician, VAMHCS 2006-2012 Member, UMSOM Institutional Review Board #2 – In addition, I provide neurological consultation and VA representations to other boards on an ad hoc basis. 2010-present Member, University of Maryland School of Medicine Research Computing Advisory Board 2010-present Medical Scientist Training Program Advisory Board 2007-2015 Deputy Director for Robotics and Technology Development, Veterans Affairs Maryland Exercise and Robotics Center of Excellence (MERCE) 2015-present Director, Veterans Affairs Maryland Exercise and Robotics Center of Excellence (MERCE)

L o c a l a nd N a tion a l S e rv i ce

1999-2000 NIH Fellows’ Committee co-chair – I was the clinical representative of NINDS to FelCom, the representative body of the hundreds of post-doctoral fellows in the NIH intramural program. I was actively involved in presenting educational programs (e.g. the Tools of the Trade professional development series), careers fairs, and running an award program. In addition, I worked with NIH administration on issues of importance to fellows. 2002-2003 Alzheimer's Association grant program 2003-2007 Ad hoc member of Brain Disorders and Clinical Neurology (now Clinical Neuroscience and Disease) study section, NIH. 2004-2007 Ad hoc member BDCN Member Conflicts Special Emphasis Panel, NIH 2005-2007 Ad hoc member of MDCN-K(50, 51) Neurotechnology/Engineering, Neuroinformatics and Neuroimaging Special Emphasis Panels 2007-present Ad hoc member of Neurological Sciences and Disorders (K, George F. Wittenberg, MD, PhD p. 5 clinical trials) study section, NIH 2000-present Department of Veteran's Affairs Rehabilitation Centers Review, RR&D Merit Review, Capacity Building

George F. Wittenberg, MD, PhD p. 6 2003-present American Society of Neurorehabilitation (ASNR) 2003-2008 ASNR Board of Directors 2006-present Program Committee ACRM-ASNR Annual Meeting 2009-2010 Program Committee Chair, ASNR 2010-2012 Treasurer, ASNR 2012-2014 Vice-President, ASNR 2014- President, ASNR

2006-present Abstract Reviewer for Human Brain Mapping Conference 2007-present United Cerebral Palsy Research Foundation Board of Scientific Advisors 2009 American Acad. Neurology: chaired Rehabilitation/Repair session 2009 Ad hoc reviewer for NIH study section DEV Other reviews: grant review for Canada, British Columbia, New Zealand; journal review including: Journal of Neurophysiology, Journal of Physiology, Neurorehabilitation and Neural Repair, Stroke, Experimental Brain Research, Clinical Neurophysiology 2010-present United Cerebral Palsy of Central Maryland (now Unified Community Connections) – Board of Directors 2014-present Standing Member, NICHD K study section (Function, Integration, and Rehabilitation Sciences)

T e a ching S e rvice

B a sic S ci e nc e s Spring ‘02, ‘04, ‘06 Course Director Wake Forest University Neuroscience Program 703 “Clinical Neuroscience” – 5 hours per week, 4- 11 students in the course Fall ’09 - 14 Lecturer, Foundations of Physical Therapy, U. Maryland Spring ’16 Lecturer, Basic Neuroscience Course, SoM, U. Maryland

C linic a l S ci e nc e s/Duti e s M e dic a l S tud e nts 2002 Evidence-Based Medicine Course, small group leader, Wake Forest University School of Medicine 2000-2006 Neurorehabilitation lecture to 3rd year Neurology Clerkship students at Wake Forest University. Given every 8 weeks to 10 students. Graded essay on neurorehabilitation. 2006-present University of Maryland School of Medicine: participated in multiple teaching events, including small group physical exam training, history and physical presentations, pathophysiology small groups. George F. Wittenberg, MD, PhD p. 7 R e sid e nts a nd M e dic a l S tud e nts 2000-2006 Wake Forest University School of Medicine: Inpatient Rehabilitation. (1 Neurology resident, 2 medical students) Attending physician for half of 38 bed rehabilitation unit. Daily rounds and additional ad hoc teaching. 3 hours/day, 3 months/year. 2000-2006 Wake Forest University School of Medicine: Stroke Inpatient service. (1 Neurology resident, 1 Internal Medicine Intern, 3 medical students) 3 hours/day, 2-4 weeks/year. 2007, 2008 University of Maryland School of Medicine: VA Neurology consult/outpatient services. (1 Neurology resident, 1 psychiatry intern, 3-5 medical students). Attending physician for three afternoon clinics each week, with expanded team. Repeated for 6 hours/day, 1 month/year. 2007, 2008 University of Maryland School of Medicine: UMMC Neurology consultation service, (3 Neurology residents, 1 Neurosurgery resident, and 3 medical students in Neurology consultations throughout hospitals, including ED and ICU. Taught medical students in small group sessions, one-on- one with residents on weekends. One-half month, 5 hours/day. 2007 University of Maryland School of Medicine: UMMC Neurology inpatient service (3 Neurology residents, 1 psychiatry intern, 2 medical students.) One-half month, 5 hours/day. 2008 Preceptorship for Anesthesia Pain Fellows (3) in Brain Health and Spasticity Clinic. 4 months/year, 5 hours/week. 2008-present Overview of Neurorehabilitation for Neurology Residents. One hour lecture, 12 residents in attendance, one a year.

MENTO R S HIP Junior Faculty 2006-2012 Sandy McCombe Waller, Assistant Professor, Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine 2007-2008 Susanne Morton, Assistant Professor, Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine 2008-2010 Lauren Jones-Lush, PhD, Institutional K12 Clinical Research Training Program 2011-present Michael Dimyan, MD, Neurology, Pepper Center Junior Faculty Award and NIH K23 Award 2012-present Kelly Westlake, PT, Ph.D., Physical Therapy and Rehabilitation Science

George F. Wittenberg, MD, PhD p. 8 Postdoctoral Fellows 2003-2004 Christopher Lovelace, PhD. (Wake Forest University) Currently Asst. Prof. of Psychology at Shepherd U., West Virginia 2006-2007 Timothy Judkins. PhD. PTRS T32 postdoctoral fellow. Currently partner in Intelligent Automation Inc. 2006-2008 Lewis Wheaton, PhD. VA Research Scientist. 2006-2012 Alison Cernich, PsyD. VA Psychology Service. 2007-2009 Lauren Jones-Lush, PhD. Advanced Rehab. Training Pgm. 2009-2014 Ron Goodman, PhD. VA. 2011-2012 Shailesh Kantak, UMANRRT (NIDDR) Fellow 2012-2014 Crystal Massie, UMANRRT (NIDDR) Fellow 2012-present Jeremy Rietschel, VA CDA-1 2013-2014 Sandeep Mani, post-doctoral fellow

Graduate students 2005 Chair, Dissertation Committee, Travis Meyer, Neurobiology and Anatomy, Wake Forest University. PhD awarded 2005. 2004-2007 Chair, Dissertation Committee, Nicole Procacci, Neuroscience Program, Wake Forest University. Advanced to Candidacy 2004. Awarded PhD 2007. 2005 Member, Dissertation Committee, Nick Bentley, Neurobiology and Anatomy, Wake Forest University, 2004-2006 Member, Dissertation Committee, Alexandre Quevedo, Neurobiology and Anatomy Wake Forest University 2011-present Member, Dissertation Committee, Timothy Meeker, Program in Neuroscience, University of Maryland 2012-present Member, Dissertation Committee, Chandler Sours, Program in Neuroscience, University of Maryland 2012-present Member, Dissertation Committee, Mark Kvarta, Program in Neuroscience and MSTP, University of Maryland 2012-present Member, Dissertation Committee, Elizabeth Woytowicz, Physical Therapy and Rehabilitation Science, University of Maryland 2013-present Member, Dissertation Committee, Hai-Wen Chen, Program in Neuroscience and MSTP, University of Maryland 2014-present Member, Dissertation Committee, Anthony Park, Program in Neuroscience and MSTP, University of Maryland

Post-baccalaureate 2004-2006 Don Foster. Currently Principal Research Associate at Alnylam Pharmaceuticals.

George F. Wittenberg, MD, PhD p. 9 Gr a nt S u pp ort

Active Gr a nts

6/20/11 – 4/20/17 Principal Investigator, 25% effort Driving Cortical Plasticity for Rehabilitation of Reaching after Stroke NIH, NICHD (NCMRR) R01 HD061462 Current year – Direct costs, $245,227; indirect, $63,759

1/1/14 – 12/31/16 Principal Investigator, 12.5% effort, Brain Neurophysiological Biomarkers of Functional Recovery in Stroke. I21 RX001429-01. VA Merit Review, Rehabilitation Research and Development Total Direct Costs: $200,000 over two years, with one year no cost extension

7/01/15-6/30/19 Principal Investigator, 25% effort Neurophysiological and Kinematic Predictors of Response in Chronic Stroke VA Merit Review, Rehabilitation Research and Development Direct costs: total, $1,090,000 (Funding Letter received) Indirect costs: N/A

P e nding Gr a nts

10/01/16 – 9/30/20 Principal Investigator, 25% effort Cortical Transfer Function for Induction of Plasticity NIH, NIMH R01 MH111873-01 Total Direct Costs: $2,068,039

C om p l e t e d Gr a nts

12/01/98-1/30/05 P.I. (taken over from the late T. Pons), 25% effort Implications of Cortical Plasticity for Rehabilitation NIH NICHD (NCMRR) P01 HD35955, Direct costs: $526,516; Indirect costs: $229,476

1/1/02-12/31/05 Principal Investigator, 30% effort The Neural Basis of Self-Care; Normal Physiology & Recovery after Stroke American Heart Association Scientist Development Grant Direct costs: $260,000; Indirect costs: $65,000 George F. Wittenberg, MD, PhD p. 10 4/1/05 - 3/31/09 Co-Investigator, 8% effort P.I. Robert Coghill Supraspinal Processing of Sensory Aspects of Pain NIH, NINDS R01 NS039426 Direct costs: $1,000,000; Indirect costs: $372,838

5/2/02-3/31/06 Principal Investigator 30% effort (taken over D. Good) Motor Map Plasticity in Constraint Therapy for Stroke Type & Effective Dates: R01 HD 40984 Funding agency: NIH, NICHD (NCMRR) Direct costs: $1,662,332; Indirect costs: $615,062

6/1/07 - 5/31/08 Principal Investigator, 10% effort Motor Cortical Stimulation as an Adjunct to Robotic Rehabilitation NIH (National Capital Area Rehabilitation Research Network) Direct costs: total, $25,000 Indirect costs: N/A

11/1/07 - 10/31/08 Principal Investigator, 20% effort Motor Cortex Stimulation and Robotic Rehabilitation Training Internal Pilot Grant, Pepper Center (NIH), VA Center of Excellence Direct costs: total, $30,000 Indirect costs: N/A

9/09/05 - 8/30/08 Principal Investigator, 25% effort Motor-Functional Neuroanatomy in Cerebral Palsy NIH, NICHD (NCMRR) R21 HD049019 Direct costs: total $275,000; Indirect costs: current year $13,760, total $113,535

10/7/06 - 7/17/09 Site Principal Investigator, 25% effort PI: Albert Lo Robotic Assisted Upper-Limb Neurorehabilitation in Stroke Patients Veterans Affairs Cooperative Studies Program Direct costs: current year, $682,240, total, $1,808,412 Indirect costs: N/A

12/1/07 - 6/30/10 Principal Investigator, 36% effort Biological Predication & Correlation of Response to Robotic Arm Therapy VA Merit Review, Rehabilitation Research and Development Direct costs: current year, $358,200, total, $741,500 Indirect costs: N/A

7/1/09 – 6/30/12 Co-investigator, 25% effort, P.I. C. Bever George F. Wittenberg, MD, PhD p. 11 Evaluation of Robot Assisted Neuro-rehabilitation VA Merit Review, Rehabilitation Research and Development Direct costs: current year, $250,000, total, $750,000 (est.) Indirect costs: N/A

11/1/07-10/31/09 Principal Investigator, 10% effort Motor Cortex Stimulation and Robotic Rehabilitation Training Internal Pilot Grant, Pepper Center (NIH), VA Center of Excellence

6/30/11 – 6/30/13 Co-investigator (P.I. Bever), 25% effort Evaluation of Robot Assisted Neuro-rehabilitation VA Merit Review, Rehabilitation Research and Development Direct costs: current year, $250,000 Indirect costs: N/A

P u b lic a tions

Peer reviewed journal articles:

1. Virgin HW IV, Wittenberg GF, Unanue ER. Immune complex effects on murine macrophages I. Immune complexes suppress interferon-γ induction of Ia expression. J. Immunol. 1985; 135: 3735-3743. 2. Virgin HW IV, Kurt-Jones EA, Wittenberg GF, Unanue ER. Immune complex effects on murine macrophages II. Immune complex effects on activated macrophages cytotoxicity, membrane IL 1 and antigen presentation. J. Immunol. 1985; 135: 3745-3749. 3. Virgin HW IV, Wittenberg GF, Bancroft GJ, Unanue ER. Suppression of immune response to Listeria monocytogenes: mechanisms of immune complex suppression. Infection and Immunity 1985; 50: 343-351. 4. Levich JD, Signorella AP, Wittenberg G, Weigle WO. Macrophage handling of a tolerogen and the role of IL 1 in tolerance induction in a helper T cell clone in vitro. J. Immunol. 1987; 138: 3675-3679. 5. Lockery SR, Wittenberg G, Kristan WB Jr., Cottrell GW: Function of identified interneurons in the leech elucidated using neural networks trained by back-propagation. Nature 1989; 340: 468-471. 6. Wittenberg G, Loer CM, Adamo SA, & Kristan WB Jr. Segmental specialization of neuronal connectivity in the leech. Journal of Comparative Physiology A 1990; 167: 453-459. 7. Wittenberg G, Kristan WB Jr. Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech: II. Role of identified interneurons. J. Neurophysiol. 1992; 68: 1693-1707. 8. Wittenberg G, Kristan WB Jr. Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech: George F. Wittenberg, MD, PhD p. 12 I. Motor output pattern. J. Neurophysiol. 1992; 68: 1693-1707. 9. Randall RD, Lee SY, Meyer JH, Wittenberg GF, Gruol DL: Acute alcohol blocks neurosteroid modulation of synaptic transmission and long-term potentiation in the rat hippocampal slice. Brain Res. 1995; 701: 238-48. 10. Meyer JH, Lee S, Wittenberg GF, Randall RD, Gruol DL. Neurosteroid regulation of inhibitory synaptic transmission in the rat hippocampus in vitro. Neuroscience 1999; 90:1177-83. 11. Wittenberg GF, Bastian AJ, Dromerick AW, Thach WT, Powers WJ. Mirror movements complicate cerebral activation changes during recovery from subcortical infarction. Neurorehabilitation and Neural Repair 2000; 14:213-221. 12. Ziemann U, Wittenberg GF, Cohen LG. Stimulation-Induced Within- Representation and Across-Representation Plasticity in Human Motor Cortex. Journal of Neuroscience 2002; 22: 5563-5571. 13. Muellbacher W, Richards C, Ziemann U, Wittenberg G, Weltz D, Boroojerdi B, Cohen L, Hallett M. Improving hand function in chronic stroke. Archives of Neurology 2002; 59:1278-1282. 14. Wittenberg GF, Chen R, Ishii K, Bushara KO, Eckloff S, Croarkin E, Taub E, Gerber LH, Hallett M, Cohen LG. Constraint-Induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair 2003; 17:111-119. 15. Wittenberg GF*, Werhahn KJ*, Wassermann EM, Herscovitch P, Cohen LG. Functional connectivity between somatosensory and visual cortex in early blind humans. Eur J Neurosci. 2004 Oct; 20(7):1923-1927. (*Official co-first authors) 16. Hancox JG, Wittenberg GF, Yosipovitch G. A patient with nasal ulceration after brain surgery. Arch Dermatol. 2005 June; 141(6):796-798. 17. Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 2006; 129: 791-808. 18. Wittenberg GF, Bastings EP, Fowlkes A, Morgan TM, Good DC, Pons TP. Dynamic course of intracortical TMS paired-pulse responses during recovery of motor function after stroke. Neurorehabilitation and Neural Repair 2007 21:568-573. 19. Zhang L, Butler AJ, Sun CK, Sahgal V, Wittenberg GF, Yue GH. Fractal dimension assessment of brain white matter structural complexity post stroke in relation to upper-extremity motor function. Brain Research 2008; 1228:229-240 George F. Wittenberg, MD, PhD p. 13 20. Sawaki L, Butler A, Leng X, Wassenaar P, Mohammad Y, Blanton S, Sathian K, Nichols-Larson D, Wolf S, Good D, Wittenberg GF. Constraint-induced Movement Therapy results in increased motor map area in subjects 3-9 months after stroke. Neurorehabilitation and Neural Repair 2008; 22 (5):505-513. 21. Procacci NM, Stanford TR, Wittenberg GF. The relationship between visual orienting and interlimb synchrony in a patient with a superior parietal infarction: A case study. Neurocase 2009; 26:1-16. 22. Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, Coghill RC. Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009; 29:2684-2694. 23. Wittenberg GF, Schaechter JD. The neural basis of constraint- induced movement therapy. Curr Opin Neurol. 2009 Sep 5 [Epub ahead of print] 24. Wittenberg GF. Motor mapping in cerebral palsy. Dev Med Child Neurol. 2009 Oct;51 Suppl 4:134-9. 25. Wittenberg GF. Neural plasticity and treatment across the lifespan for motor deficits in cerebral palsy. Dev Med Child Neurol. 2009 Oct;51 Suppl 4:130-3. 26. Lo AC, Guarino P, Krebs HI, Volpe BT, Bever CT, Duncan PW, Ringer RJ, Wagner TH, Richards LG, Bravata DM, Haselkorn JK, Wittenberg GF, Federman DG, Corn BH, Maffucci AD, Peduzzi P. Multicenter Randomized Trial of Robot-Assisted Rehabilitation for Chronic Stroke: Methods and Entry Characteristics for VA ROBOTICS. Neurorehabil Neural Repair. 2009 Oct;23 (8): 775-783. 27. Wittenberg GF. Experience, cortical remapping, and recovery in brain disease. Neurobiol Dis. 2010 Feb; 37 (2): 252-258. 28. Jones-Lush LM, Judkins TN, Wittenberg GF. Arm movement maps evoked by cortical magnetic stimulation in a robotic environment. Neuroscience 2010 Feb 3;165 (3):774-781 29. Lo AC, Guarino PD, Richards LG, Haselkorn JK, Wittenberg GF, Federman DG, Ringer RJ, Wagner TH, Krebs HI, Volpe BT, Bever CT Jr, Bravata DM, Duncan PW, Corn BH, Maffucci AD, Nadeau SE, Conroy SS, Powell JM, Huang GD, Peduzzi P. Robot-assisted therapy for long-term upper-limb impairment after stroke. N Engl J Med. 2010 May 13;362(19):1772-83. doi: 10.1056/NEJMoa0911341.

30. Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain:insights from structural connectivity and brain lesions. Brain. 2011 Jul;134(Pt 7):1987-2004. Epub 2011 May 26. PubMed PMID: 21616963; PubMed Central PMCID: PMC3122370. George F. Wittenberg, MD, PhD p. 14 31. Wittenberg GF. Elastic properties and yield stress of fetal membranes. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2123-6. PubMed PMID: 22254757 32. Conroy SS, Whitall J, Dipietro L, Jones-Lush LM, Zhan M, Finley MA, Wittenberg GF, Krebs HI, Bever CT. Effect of gravity on robot-assisted motor training after chronic stroke: a randomized trial. Arch Phys Med Rehabil. 2011 Nov;92(11):1754-61. Epub 2011 Aug 17. PubMed PMID: 21849168. 33. Wagner TH, Lo AC, Peduzzi P, Bravata DM, Huang GD, Krebs HI, Ringer RJ,Federman DG, Richards LG, Haselkorn JK, Wittenberg GF, Volpe BT, Bever CT, Duncan PW, Siroka A, Guarino PD. An economic analysis of robot-assisted therapy for long-term upper-limb impairment after stroke. Stroke. 2011 Sep;42(9):2630-2. Epub 2011 Jul 14. PubMed PMID: 21757677. 34. Kesar TM, Sawaki L, Burdette JH, Cabrera N, Kolaski K, Smith BP, O’Shea TM, Koman LA, Wittenberg GF. Functional Relevance of Abnormalities in Motor Cortex Representational Geometry in Cerebral Palsy. Dev. Med. & Child Neurol. 2012 Jul;123(7):1383-90. Epub 2011 Dec 6. PubMed PMID: 22153667; PubMed Central PMCID: PMC3309071. 35. Krakauer JW, Carmichael ST, Corbett D, Wittenberg GF. Getting neurorehabilitation right: what can be learned from animal models? Neurorehabil Neural Repair. 2012 Oct;26(8):923-31. Epub 2012 Mar 30. PubMed PMID: 22466792. 36. Wittenberg GF, Lovelace CT, Foster DJ, Maldjian JA. Functional neuroimaging of dressing-related skills. Brain Imaging Behav. 2012 Oct 16. PubMed PMID: 23070748 37. Kantak SS, Wittenberg GF, Liao WW, Magder LS, Rogers MW, Waller SM. Posture-related modulations in motor cortical excitability of the proximal and distal arm muscles. Neurosci Lett. 2012 Nov 1. pii: S0304- 3940(12)01416-4. S0304-3940(12)01416-4.10.1016/j.neulet.2012.10.048. [Epub ahead of print] PMID: 23123777 38. Kantak SS, Jones-Lush LM, Narayanan P, Judkins TN, Wittenberg GF. Rapid Plasticity of Motor Cortex with Robotic Reach Training. Neuroscience. 2013 Sep 5;247:55-64. doi: 10.1016/j.neuroscience.2013.05.001. PMID: 23669007 39. Dutta TM, Josiah AF, Cronin CA, Wittenberg GF, Cole JW. Altered taste and stroke: a case report and literature review. Top Stroke Rehabil. 2013 20(1):78-86. PMID: 23340074. 40. Massie C, Narayanan P, Kantak SS, Jones-Lush LM, Judkins TN, Wittenberg GF. Effects of Motor Cortical Stimulation during Planar Reaching. J Rehab Robotics 2013 1:42-53, DOI: http://dx.doi.org/10.12970/230 8 -8354.2013.01.01. 5 . George F. Wittenberg, MD, PhD p. 15 41. Ommaya AK, Adams KM, Allman RM, Collins EG, Cooper RA, Dixon CE, Fishman PS, Henry JA, Kardon R, Kerns RD, Kupersmith J, Lo A, Macko RF, McArdle R, McGlinchey RE, McNeil MR, O'Toole TP, Peckham PH, Tuszynski, MH, Waxman SG, Wittenberg GF. Research opportunities in rehabilitation research. Journal of Rehabilitation Research and Development Sept. 2013 (now online). J Rehabil Res Dev. 2013 50(6):vii- xxxii. doi: 10.1682/JRRD.2012.09.0167. PMID: 24203548 42. Matthews CC, Fishman PS, Wittenberg GF. Tetanus Toxin Reduces Local and Descending Regulation of the H-Reflex. Muscle and Nerve 2013, DOI: 10.1002/mus.23938 43. Beets I, Gooijers J, Boisgontier M, Pauwels L, Coxon J, Wittenberg GF, Swinnen SP. Reduced neural differentiation between feedback conditions after training bimanual coordination with and without augmented visual feedback, Cerebral Cortex 2014, Feb DOI:10.1093/cercor/bhu005 44. Boisgontier MP, Wittenberg G, Fujiyama H, Levin O and Swinnen SP. Complexity of central processing in simple and choice multi-limb reaction time tasks. PLoS One. 2014 Feb 28;9(2):e90457. doi: 10.1371/journal.pone.0090457. PMID: 24587371. 45. Wittenberg GF and Dimyan MA. How do the physiology and transcallosal effects of the unaffected hemisphere change during inpatient rehabilitation after stroke? (editorial) Clin. Neurophysiol., 2014 Feb 28. pii: S1388-2457(14)00117-5. doi: 10.1016/j.clinph.2014.02.016. 46. Massie C, Kantak SS, Narayanan P, Wittenberg GF. Timing of motor cortical stimulation during planar robotic training differentially impacts neuroplasticity in older adults. Clin Neurophysiol. 2014 Sep 16. pii: S1388-2457(14)00482-9. doi: 10.1016/j.clinph.2014.06.053. [Epub ahead of print] PMID: 25283712 47. Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Nichols-Larson DS, Wolf SL, Good DC, Wittenberg GF. Differential patterns of cortical reorganization following constraint-induced movement therapy during early and late period after stroke: a preliminary study. NeuroRehabilitation, 2015, [Epub ahead of print].

48. Rietschel JC. McDonald CG, Goodman RN, Miller MW, Jones-Lush LM, Wittenberg GF, Hatfield, BD. Psychophysiological support of increasing attentional reserve during the development of a motor skill. Biological Psychology 2014 Dec;103:349-56. doi: 10.1016/j.biopsycho.2014.10.008. Epub 2014 Oct 23. PMID: 25457640

49. Massie C, Yue, D, Conroy S, Krebs HI, Wittenberg GF, Bever C, Whitall J. A clinically relevant method of analyzing continuous change in robotic upper- extremity chronic stroke rehabilitation. Neurorehabil Neural Repair. 2015 Dec 14. pii: 1545968315620301. [Epub ahead of print] PubMed PMID: 26671216. George F. Wittenberg, MD, PhD p. 16 Non-peer-reviewed journal articles:

1. Kristan WB Jr., Wittenberg G, Nusbaum MP Jr., Stern-Tomlinson W: Multifunctional interneurons in behavioral circuits of the medicinal leech. Experientia (1988) 44: 383-389. 2. Wittenberg G. review of: Zornetzer SF et al. An Introduction to Neural and Electronic Networks. in: Quart Rev. Biol. 1990; 66: 517. 3. Wittenberg G. review of: Toole JF and Good DC. Imaging in Neurologic Rehabilitation. in: J. Neurol. Rehab. 1998; 12:88. 4. Wittenberg GF, Cohen LG. Multiple pathways for plasticity: the role of degeneration in deafferentation-induced CNS reorganization. Neurology Network Commentary 1999 Dec; 3(1): 321-324. 5. Wittenberg GF. review of Cramer SC and Nudo RJ. Brain Repair After Stroke. In: The Neurologist 2012 18(6): 4301.

6. Byblow W, Schlaug G, Wittenberg G. What's the perfect dose for practice to make perfect? Ann Neurol. 2016 Sep;80(3):339-41. doi: 10.1002/ana.24735. Epub 2016 Aug 13.

Books: 1. Stein J, Harvey RL, Winstein CJ, Zorowitz RD, Wittenberg GF, eds. Stroke Recovery and Rehabilitation, 2nd ed., New York, NY: Demos Medical, 2014 Book chapters:

1. Kristan WB Jr., Lockery SR, Wittenberg G, & Cottrell GW. Behavioral choice - in theory and in practice. in: The computing Neuron, Richard Durbin, et al., eds. Wokingham, UK: Addison-Wesley, 1989. 2. Kristan WB Jr., Lockery SR, Wittenberg G, Brody D. Making behavioral choices with interneurons in a distributed system. in: Neurobiology of motor programme selection. Oxford, UK: Pergamon Press, 1992.

2. Wittenberg GF, Massie CL, Westlake KP. Anatomical and Physiological Predictors of Recovery. in: Stein J, et al., Stroke Recovery and Rehabilitation, 2nd ed. New York, NY: Demos, 2014.

Abstracts and conference proceedings:

1. Wittenberg G, Kristan WB Jr. Behavioral choice in an isolated simple leech nervous system: shortening vs. swimming in the leech. 2nd Annual M.D.-Ph.D. Student Conference (1987), Aspen, Colorado: P46.

George F. Wittenberg, MD, PhD p. 17 2. Wittenberg G, Kristan WB Jr. Behavioral choice in the isolated leech nervous system: shortening vs. swimming. Soc. for Neurosci. Abstr. (1987) 13: Part 1, p. 388. 3. Wittenberg G, Kristan WB Jr. Behavioral choice in the leech : characterization of the shortening motor pattern. Soc. for Neurosci. Abstr. (1988) 14: Part 1, p. 690. 4. Lockery SR, Wittenberg G, Kristan WB Jr., Sejnowski TJ. Connections of identified interneurons in the leech arise in networks trained by back- propagation. Soc. for Neurosci. Abstr. (1989) 15: Part 2, p. 1119. 5. Lockery SR, Wittenberg G, Kristan WB. Multifunctional role of interneurons in the leech elucidated using neural networks trained by back-propagation. in: Neural Mechanisms of Behavior: proceedings of the 2nd international congress of neuroethology (1989), Erber J, et al., eds. Stuttgart: Thieme. 6. Wittenberg G, Kristan WB Jr. Intersegmental interneurons contribute to multiple behaviors in the leech. Soc. for Neurosci. Abstr. (1989) 15: Part 2, p. 1119. 7. Wittenberg G, Kristan WB Jr. Generation of the shortening motor pattern in the medicinal leech. Soc. for Neurosci. Abstr. (1990) 16: Part 2, p. 1131. 8. Randall RD, Meyer JH, Wittenberg G, Gruol DL. Ethanol blocks increase in LTP mediated by dehydroepiandrosterone sulfate (DHEAS) in CA1 of rat hippocampal slice. Soc. for Neurosci. Abstr. (1993) 19: Part 1, p. 378. 9. Meyer JH, Wittenberg G, Randall RD, Gruol DL. Dehydroepiandrosterone sulfate affects LTP in area CA1 of the rat hippocampus. Soc. for Neurosci. Abstr. (1993)19: Part 2, p. 1328. 10. Wittenberg GF, Bastian AJ, Dromerick AW, Thach WT, Powers WJ. Cerebral Activation Changes During Post-Stroke Motor Recovery. Soc. for Neurosci. Abstr. (1998) 24, Part 2, p. 1262. 11. Wittenberg GF, Chen R. Ishii K, Croarkin E, Eckloff S, Gerber L, Taub E, Hallett M, Cohen LG. Effect of constraint-induced movement therapy on motor function and cortical physiology in chronic stroke. World Congress of Neurorehabilitation (1999), Toronto, ON, Canada. Neurorehab. Neural Repair 13: 49. 12. Wittenberg GF, Bushara K, Werhahn KJ, Wassermann EM, Horwitz B, Herscovitch P, Cohen LG. Cortical somatosensory-visual connections in the blind revealed by repetitive transcranial magnetic stimulation during PET. Soc. for Neurosci. Abstr. (2000) 26, Part 2, 686.1. 13. Cohen LG, Wittenberg G. Study of anatomical connectivity with TMS- PET in intact humans. Society for Biological Psychiatry Annal Meeting (2000) Biol Psychiat 47(8 Suppl.): 65S.

George F. Wittenberg, MD, PhD p. 18 14. Wittenberg GF, Chen R. Ishii K, Croarkin E, Eckloff S, Gerber L, Taub E, Hallett M, Cohen LG. (2000) Task-related and resting regional cerebral bloodflow changes after constraint-induced movement. Neurology 54(7, S3): A8. 15. Wittenberg G, Bastings E, Burdette J, Scales C, Good D. Evaluation of TMS motor maps during recovery after stroke. Human Brain Mapping (2001) Brighton, England, UK. NeuroImage 13(6, pt. 2): S1281. 16. Yen YF, Bastings E, Burdette J, Scales C, Greenberg J, Wittenberg G, Good D, Pons T. Longitudinal evaluation of activation of primary motor cortex with fMRI on subcortical stroke patients during recovery. Human Brain Mapping (2001) Brighton, England, UK. NeuroImage 13(6, pt. 2): S853. 17. Smith S, Bastings EP, Morgan T, Pons TP, Good DC, Wittenberg GF. Paired - Pulse Inhibition and Facilitation of Motor Evoked Potentials after Cerebral Infarction: A Longitudinal Study with Transcranial Magnetic Stimulation. Soc. for Neurosci. Abstr. (2002) 28, 562.8. 18. Wittenberg GF, Smith S, Bastings EP, Morgan T, Pons TP, Good DC. Dynamic course of intracortical interactions during recovery of motor function after stroke: A TMS paired-pulse study. in: Paulus W, et al. (Eds.); Proceedings of the 2nd International Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) Symposium, Göttingen, Germany, 11 – 14 June (2003). Clin. Neurophysiol. Suppl. 56. 19. Sawaki L, Butler AJ, Wassenaar P, Mohammad Y, Fowlkes A, Greenberg J, Nichols DS, Wolf SL, Good DC, Wittenberg GF. (2004) Motor Map Plasticity in Constraint Therapy for Stroke. International Stroke Conference (2004), Stroke 35:284. 20. Wittenberg GF, Lovelace CT, Foster DJ, Maldjian JA. The Physiology of Self-Care: Functional Imaging of Dressing Tasks After Recovery from Stroke. International Stroke Conference (2004), Stroke 35: 285. 21. Wittenberg G, Foster DJ, Lovelace CT. Brain Activity in Activities of Daily Living after Stroke. Human Brain Mapping (2005), Toronto, ON, Canada. NeuroImage 26(S1): S32. 22. Wittenberg G, Foster DJ Superior Parietal Lobe Activation in Recovery of Functional Ability after Stroke. Neural Control of Movement Society Annual Meeting (2005), Key Biscayne, FL. 23. Wittenberg G, Sawaki L, Cabrera N, Kolaski K, Smith BP, O'Shea M, Koman LA Transcranial Magnetic Stimulation Reveals a Range of Motor Map Abnormalities in Children with Cerebral Palsy. Human Brain Mapping (2007), Chicago, IL, Neuroimage 36(S1). 24. Jones-Lush, LM, Judkins TN, Wittenberg GF Magnetic cortical stimulation and arm movements in a robotic environment. Soc. for Neurosci. Abstr. (2008) 861.1. George F. Wittenberg, MD, PhD p. 19 25. Judkins TN, Jones-Lush, LM, Wittenberg GF 861.2/JJ16 - Motor cortical plasticity induced by repetitive robotic training. Soc. for Neurosci. Abstr. (2008) 861.2. 26. Wittenberg GF, Judkins TN, Jones-Lush, LM (2009). Transcranial magnetic stimulation of arm motor cortex in a robotic training environment: movement representations and plasticity. Progress in Motor Control VII, Marseille, France. 27. Westlake KP, Greenberg JP, Yen YF, Good DC, Wittenberg GF. Characterizing the dynamics of brain plasticity in relation to motor recovery from an early acute to chronic stage after stroke. Soc. For Neurosci. Abstr. (2012) 351.10. 28. Kantak SS, Jones-Lush L, Zhan M, Lush J, Narayanan P, Mccombe Waller S, Wittenberg GF. Practice induced changes in the motor cortical representation for multi-joint goal-directed reaching movements. Soc. for Neurosci. Abstr. (2012) 830.02 Nanosymposium on Reaching Control: Motor Learning II. 29. Rietschel JC, Goodman RN, McDonald CG, Miller MW, Jones-Lush L, Wittenberg GF, Hatfield BD. Psychophysiological investigation of attentional processes during motor skill learning. Soc. for Neurosci. Abstr. (2012) 904.13. 30. Massie C, Kantak SS, Narayanan P, Judkins T, Wittenberg GF. Practice and stimulation induce shifts in TMS-evoked 2D movements involving multiple joints of the upper limb. Fifth International Conference On Non- Invasive Brain Stimulation, Leipzig, Germany, April 2013. 31. Gorelick DA, Holcomb HH, Boggs DL, West JT, Wittenberg GF, Lee MR, Huestis MA. Individual differences in fMRI cortical bold responses to nicotine visual cues in dependent cigarette smokers. Society of Biological Psychiatry’s 68th Annual Meeting, San Francisco, CA, May 2013.

M a jor Invit e d Sp ee ch e s a nd C ours e s S p ee ch e s

Local January 2003. Wake Forest Neurology Grand Rounds: Cortical Motor Representation during Recovery of Motor Function after Stroke. Winston- Salem, NC June 2003. Wake Forest Geriatrics Grand Rounds: Cortical Motor Representation during Recovery of Motor Function after Stroke. Winston- Salem, NC October 2004. Wake Forest University Geriatrics Fellowship Seminar Series: Management of Stroke Beyond the Acute Phase. Winston- Salem, NC

George F. Wittenberg, MD, PhD p. 20 October 2003. Wake Forest Psychiatry Residency Program Seminar Series: Language — from a Neurology & Rehabilitation Perspective. Winston- Salem, NC September 2005. Wake Forest University Vascular Dementia Symposium: The role of rehabilitation science and clinical practice in vascular dementia treatment. Winston-Salem, NC March 2006. Neurology Update for Primary Care Physicians Parkinson’s Disease: Current Treatment Options. Wake Forest University CME program. Winston-Salem, NC May 2006. Wake Forest University Dept. of Neurology Grand Rounds: Brain Activity in Activities of Daily Living: Practical Motor Function before and after Stroke. Winston-Salem, NC December 2007. University of Maryland, Dept. of Neurology Grand Rounds: Engineering Approaches to Rehabilitation of Stroke and Other Brain Disorders. Baltimore, MD. February 2008. Maryland Psychiatric Research Center. Neurobiological Approaches to Motor Recovery & Rehabilitation After Stroke and Cerebral Palsy. Catonsville, MD.

National June 1999. NIH Clinical Center, Department of Rehabilitation Medicine Grand Rounds: Stroke and Stroke Rehabilitation. Bethesda, MD March 2002. Presentation to the Burke Foundation: Cortical stimulation as an adjunct in rehabilitation. Invited presentation to rehabilitation research foundation. New York, NY July 2002. Emory University, Department of Rehabilitation Medicine Grand Rounds: Cortical Motor Representation during Recovery of Motor Function after Stroke. Atlanta, GA March 2003. National Institute of Neurological Disorders and Stroke, Grand Rounds: The Changing Cortical Motor Representation After Stroke. Bethesda, MD February 2004. Charlotte Institute of Rehabilitation Rounds: Activities of Daily Living: Practical Motor Function before and after Stroke. Charlotte, NC December 2004. Emory University, Department of Neurology Grand Rounds: Motor Maps after Perinatal Brain Injury & Stroke. Atlanta, GA April 2005. Washington University Dept. of Neurology and Neurosurgery Research Seminar: Neurobiological Approaches to Motor Recovery & Rehabilitation After Stroke. St. Louis, MO October 2005. University of Maryland, Dept. of Neurology Special Seminar: Motor Cortical Changes after Perinatal Brain Injury & Stroke. Baltimore, MD June 2007. NSF Science of Learning Center, Arizona State University. Neurobiological Approaches to Motor Recovery & Rehabilitation After Stroke and Cerebral Palsy. Tempe, AZ.

George F. Wittenberg, MD, PhD p. 21 October 17, 2007 ACRM-ASNR Joint Educational Conference Breakfast symposium, Neuroimaging in Rehabilitation: How does it make us look? Chicago, IL. February 2008. Pennsylvania State University. Dept. of Neurology Grand Rounds: Engineering Approaches to Rehabilitation of Stroke and Other Brain Disorders. Hershey, PA. February 2008. National Institute of Aging. Brain Activity in Activities of Daily Living: Practical Motor Function before and after Stroke. Baltimore, MD. March 2008. American Society for Neurotherapeutics (ASENT) Neurorehabilitation. Long-term Outcomes. Arlington, VA. September 2008. AACPDM pre-conference workshop. Adults with Cerebral Palsy: A Workshop to Define the Challenges of Treating and Preventing the Secondary Musculoskeletal and Neuromuscular Complications in this Rapidly Growing Population. Atlanta, GA. November 2008. Society for Neuroscience Annual Meeting. Director, Minisymposium: The Cortical Motor Map in Stroke Rehabilitation, and lecture within it: Probing Movement Maps in Health and Disease through Transcranial Magnetic Stimulation. Washington, DC. September 2010. Motor Control Group Talk. Trancranial Magnetic Stimulation of Arm Motor Cortex in a Robotic Training Environment. National Rehabilitation Hospital, Washington, DC. November 2010. BIOMS Lecture. Trancranial Magnetic Stimulation of Arm Motor Cortex in a Robotic Training Environment. University of Delaware, Newark, DE.

International June 2003. Presentation at Neurological Therapy Centre, Heinrich-Heine- University Düseldorf, Germany: Neurobiological Approaches to Motor Recovery & Rehabilitation After Stroke. January 2005. Brain Research Centre Seminar: Brain Activity in Activities of Daily Living: Practical Motor Function before and after Stroke. Vancouver, BC, Canada April 2005. McGill University, Jewish General Hospital Dept. of Neurology Grand Rounds: Neurobiological Approaches to Motor Recovery & Rehabilitation After Stroke. Montreal, QC, Canada. July 2005. Conférences scientifique du Centre de recherché interdisciplinaire en réadaptation du Montréal métropolitain: Brain Activity in Activities of Daily Living: Practical Motor Function before and after Stroke. Montreal, QC, January 2005. Rotman Research Institute Seminar: Brain Activity in Activities of Daily Living: Practical Motor Function before and after Stroke. Toronto, ON, Canada Oct 2008 ASNR/ACRM Joint Educational Conference. Symposium Lecture: Cortical Control of Voluntary Movement after Stroke: A Look into the Black Box. Toronto, ON, Canada. September 2012. Centre for Research in Mechatronics seminar series. Engineering Brain Changes after Stroke. Université catholique de Louvain, Louvain-la-Neuve, Belgium. George F. Wittenberg, MD, PhD p. 22 October 2012. Movement Control and Neuroplasticity Group seminar series. TMS & Robotic Reach Rehabilitation; Plasticity in Movement Representation. KU Leuven, Leuven, Belgium. January 2013. ANT Burgundy Neuromeeting; Plasticity in TMS-evoked Movements with Robotic Reach Training. Beaune, France. February 2013. “Technology and the Brain in Rehabilitation for Stroke and Cerebral Palsy.” KU Leuven Neuromotor Rehabilitation Group Meeting. Leuven, Belgium. June 2013. “Training and the Brain in Rehabilitation for Stroke” VU Amsterdam, Motor Rehabilitation Group Lecture. Amsterdam, The Netherlands. March 2014. Reaching, Robots, and Rehabilitation; Brain Activity and the Effects of Practice. University of Ottawa, Program in Neuroscience. Ottawa, ON, Canada. March 2014. Rehabilitation of Arm Motor Function after Stroke. University of Ottawa Department of Neurology Grand Rounds. Ottawa, ON, Canada. October 2014. Brain Activity and the Effects of Reaching Practice. Quarterly Interdisciplinary Research Meeting, UM Rehabilitation Network.

C ours e s

March 2001. Neurology Update for Primary Care Physicians: Management of Stroke Beyond the Acute Phase. Wake Forest University CME program. Winston-Salem, NC March 2002. Neurology Update for Primary Care Physicians: Parkinson’s Disease; Current Diagnosis and Treatment Wake Forest University CME program. Winston-Salem, NC March 2003. Neurology Update for Primary Care Physicians: The Neurological Exam: Brush-Up & Enhancement. Wake Forest University CME program. Winston-Salem, NC October 2003. ACRM-ASNR Joint Educational Conference: Positron Emission Tomography in Rehabilitation Research. Tucson, AZ. October 2003. ACRM-ASNR Joint Educational Conference: The Importance Of Activity-Dependent Mechanisms To Neurorehabilitation. Course organizer/presenter. Tucson, AZ. March 2005. Neurology Update for Primary Care Physicians: “Current Treatment Options” Wake Forest University CME program. Winston-Salem, NC April/October 2005. American Academy of Neurology/American Academy of Physical Medicine and Rehabilitation Courses: Electrophysiologic Tools to Guide Rehabilitation: Transcranial Magnetic Stimulation to Assess Motor Function after Stroke. Miami, FL (AAN) & Philadelphia, PA (AAPMR) April 2006. American Academy of Neurology Course: CNS Recovery and Reorganization Through Therapy: Changes in Cortical Motor Networks Underlying Recovery and Rehabilitation After Stroke. San Diego, CA June 2008. VA/UM CME course (Town-Gown Neurology Symposium.) Title: Engineering Solutions to Weakness and Spasticity after Stroke and other Brain Disorders. George F. Wittenberg, MD, PhD p. 23 June 2009. American Physical Therapy Association. Course:Evidence for Upper Extremity Training for The Lower Functioning Patient Post Stroke. Baltimore, MD. October 2011. Progress in Rehabilitation Research (ACRM-ASNR joint conference) Workshop on Non-invasive brain stimulation – current applications in the neurorehabilitation of patients after stroke.

George F. Wittenberg, MD, PhD p. 24