Table 4: Mean (SD) Fatty Acid Levels (G/100G Fatty Acids) in Plasma Phospholipids at The

Table 4: Mean (SD) fatty acid levels (g/100g fatty acids) in plasma phospholipids at the 4-week timepoint. Groups were compared by ANOVA, and if significant, by pairwise comparisons of treatment groups to the placebo group using the Dunnett’s test.

* p<0.05 compared to placebo group.

DHASCO-T DHASCO-S Fatty Acid Placebo 200 mg DHA 600 mg DHA 1000 mg DHA 200 mg DHA 600 mg DHA 1000 mg DHA Bars

(n=12) (n=12) (n=12) (n=12) (n=12) (n=12) (n=12) (n=12)

Saturated 40.79 (1.18) 40.71 (1.45) 41.20 (0.89) 40.67 (1.19) 40.79 (1.49) 40.70 (1.07) 40.49 (1.82) 41.15 (0.77) Monounsaturated 11.83 (1.02) 12.02 (1.22) 12.09 (1.35) 11.63 (1.33) 12.29 (0.79) 12.08 (1.24) 11.01 (1.08) 11.68 (0.91) n-3 18:3n-3 0.22 (0.06) 0.21 (0.05) 0.24 (0.08) 0.20 (0.06) 0.22 (0.08) 0.23 (0.06) 0.22 (0.09) 0.24 (0.07) 20:5n-3 0.72 (0.62) 0.56 (0.22) 0.71 (0.20) 0.81 (0.27) 0.62 (0.22) 0.90 (0.82) 0.86 (0.22) 0.72 (0.23) 22:5n-3 0.94 (0.26) 0.71 (0.19)* 0.67 (0.13)* 0.53 (0.11)* 0.82 (0.13) 0.62 (0.17)* 0.63 (0.10)* 0.74 (0.21)* 22:6n-3 3.22 (1.10) 4.34 (0.66) 5.47 (0.82)* 6.44 (1.27)* 4.32 (0.65) 5.50 (1.18)* 6.25 (1.39)* 5.53 (1.18)* Total LCn-3 4.88 (1.43) 5.62 (0.73) 6.85 (0.85)* 7.78 (1.41)* 5.77 (0.62) 7.03 (1.98)* 7.74 (1.47)* 6.98 (1.32)* n-6 18:2n-6 21.65 (4.44) 23.37 (2.26) 21.87 (2.15) 22.91 (2.14) 21.42 (3.06) 22.13 (3.07) 20.72 (3.67) 20.81 (2.78) 18:3n-6 0.11 (0.04) 0.07 (0.04) 0.11 (0.07) 0.08 (0.04) 0.09 (0.04) 0.10 (0.05) 0.07 (0.03) 0.08 (0.02) 20:2n-6 0.38 (0.09) 0.37 (0.08) 0.38 (0.09) 0.37 (0.09) 0.37 (0.07) 0.38 (0.08) 0.34 (0.06) 0.38 (0.10) 20:3n-6 3.36 (0.85) 2.86 (0.67) 3.13 (0.59) 2.58 (0.46) 3.11 (0.83) 2.92 (0.60) 2.74 (0.56) 2.99 (0.52) 20:4n-6 13.40 (2.18) 11.58 (1.50) 11.25 (1.64)* 10.97 (1.31)* 12.42 (1.81) 10.97 (1.72) 13.33 (2.69) 12.17 (1.91) 22:4n-6 0.60 (0.08) 0.47 (0.10)* 0.43 (0.05)* 0.36 (0.09)* 0.53 (0.08) 0.38 (0.09)* 0.38 (0.05)* 0.47 (0.12)* 22:5n-6 0.33 (0.09) 0.31 (0.09) 0.20 (0.07) 0.16 (0.10)* 0.60 (0.13)* 0.74 (0.16)* 0.75 (0.23)* 0.81 (0.19)* Total LCn-6 18.07 (1.77) 15.59 (2.17)* 15.39 (1.39)* 14.44 (1.64)* 17.02 (2.38) 15.39 (2.04)* 17.53 (2.79) 16.82 (0.97) Table 5: Mean (SD) fatty acid levels (g/100g fatty acids) in erythrocytes at the 4-week timepoint. Groups were compared by

ANOVA, and if significant, by pairwise comparisons of treatment groups to the placebo group using the Dunnett’s test. * p<0.05 compared to placebo group.

DHASCO-T DHASCO-S Placebo 200 mg DHA 600 mg DHA 1000 mg DHA 200 mg DHA 600 mg DHA 1000 mg DHA Bars

(n=12) (n=12) (n=12) (n=12) (n=12) (n=12) (n=12) (n=12)

Saturated 38.49 (1.32) 37.87 (1.12) 38.06 (1.08) 38.35 (0.83) 37.97 (1.16) 38.22 (0.87) 38.64 (1.51) 38.81 (0.93) Monounsaturated 19.07 (0.87) 19.21 (1.35) 19.28 (0.68) 18.90 (0.72) 19.33 (1.16) 19.02 (0.98) 18.52 (1.11) 19.26 (1.40) n-3 18:3n-3 0.18 (0.06) 0.19 (0.03) 0.21 (0.05) 0.18 (0.04) 0.21 (0.04) 0.19 (0.05) 0.18 (0.06) 0.21 (0.07) 20:5n-3 0.57 (0.23) 0.50 (0.18) 0.64 (0.15) 0.66 (0.19) 0.55 (0.17) 0.69 (0.42) 0.67 (0.15) 0.58 (0.16) 22:5n-3 2.00 (0.41) 1.80 (0.31) 1.87 (0.28) 1.68 (0.31) 1.92 (0.30) 1.75 (0.27) 1.77 (0.12) 1.76 (0.29) 22:6n-3 3.53 (0.90) 4.27 (0.83) 4.94 (0.95)* 5.89 (1.03)* 4.06 (0.74) 4.87 (1.23)* 5.30 (0.68)* 4.57 (0.81)* Total LCn-3 6.10 (0.90) 6.57 (0.88) 7.44 (0.85)* 8.24 (1.22)* 6.54 (0.93) 7.31 (1.69)* 7.73 (0.73)* 6.90 (0.95) n-6 18:2n-6 13.70 (1.98) 14.56 (1.00) 13.81 (1.46) 13.78 (1.05) 13.97 (1.63) 14.10 (1.72) 13.02 (1.17) 13.30 (1.93) 18:3n-6 0.08 (0.04) 0.05 (0.05) 0.06 (0.02) 0.06 (0.04) 0.07 (0.04) 0.04 (0.03) 0.05 (0.04) 0.06 (0.03) 20:2n-6 0.32 (0.06) 0.32 (0.05) 0.32 (0.08) 0.31 (0.06) 0.33 (0.06) 0.32 (0.07) 0.32 (0.05) 0.32 (0.07) 20:3n-6 1.73 (0.36) 1.55 (0.29) 1.67 (0.36) 1.37 (0.23) 1.62 (0.31) 1.66 (0.36) 1.50 (0.21) 1.48 (0.20) 20:4n-6 14.29 (0.93) 13.99 (0.91) 13.62 (0.72) 13.48 (1.10) 13.90 (0.83) 13.40 (1.01) 14.00 (1.19) 13.55 (0.63) 22:4n-6 3.94 (0.51) 3.68 (0.47) 3.56 (0.53) 3.39 (0.58) 3.83 (0.56) 3.59 (0.46) 3.61 (0.53) 3.63 (0.44) 22:5n-6 0.51 (0.09) 0.54 (0.13) 0.46 (0.10) 0.41 (0.14) 0.68 (0.11)* 0.81 (0.17)* 0.87 (0.09)* 0.80 (0.12)* Total LCn-6 20.79 (1.19) 20.09 (1.41) 19.63 (0.81) 18.96 (1.68) 20.35 (1.51) 19.77 (1.43) 20.30 (1.56) 19.78 (1.00)